-- dump date 20111121_013304 -- class Genbank::misc_feature -- table misc_feature_note -- id note 262316000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 262316000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316000003 Walker A motif; other site 262316000004 ATP binding site [chemical binding]; other site 262316000005 Walker B motif; other site 262316000006 arginine finger; other site 262316000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 262316000008 DnaA box-binding interface [nucleotide binding]; other site 262316000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 262316000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 262316000011 putative DNA binding surface [nucleotide binding]; other site 262316000012 dimer interface [polypeptide binding]; other site 262316000013 beta-clamp/clamp loader binding surface; other site 262316000014 beta-clamp/translesion DNA polymerase binding surface; other site 262316000015 recombination protein F; Reviewed; Region: recF; PRK00064 262316000016 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 262316000017 Walker A/P-loop; other site 262316000018 ATP binding site [chemical binding]; other site 262316000019 Q-loop/lid; other site 262316000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316000021 ABC transporter signature motif; other site 262316000022 Walker B; other site 262316000023 D-loop; other site 262316000024 H-loop/switch region; other site 262316000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 262316000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 262316000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316000028 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 262316000029 anchoring element; other site 262316000030 dimer interface [polypeptide binding]; other site 262316000031 ATP binding site [chemical binding]; other site 262316000032 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 262316000033 active site 262316000034 putative metal-binding site [ion binding]; other site 262316000035 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 262316000036 DNA gyrase subunit A; Validated; Region: PRK05560 262316000037 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 262316000038 CAP-like domain; other site 262316000039 Active site [active] 262316000040 primary dimer interface [polypeptide binding]; other site 262316000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262316000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262316000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262316000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262316000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262316000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262316000047 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 262316000048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000049 Cytochrome P450; Region: p450; cl12078 262316000050 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 262316000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 262316000052 active site 262316000053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 262316000054 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 262316000055 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 262316000056 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 262316000057 Glutamine amidotransferase class-I; Region: GATase; pfam00117 262316000058 glutamine binding [chemical binding]; other site 262316000059 catalytic triad [active] 262316000060 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316000061 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316000062 active site 262316000063 ATP binding site [chemical binding]; other site 262316000064 substrate binding site [chemical binding]; other site 262316000065 activation loop (A-loop); other site 262316000066 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316000067 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 262316000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 262316000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 262316000070 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 262316000071 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316000072 active site 262316000073 ATP binding site [chemical binding]; other site 262316000074 substrate binding site [chemical binding]; other site 262316000075 activation loop (A-loop); other site 262316000076 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 262316000077 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 262316000078 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 262316000079 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 262316000080 Active site [active] 262316000081 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316000082 phosphopeptide binding site; other site 262316000083 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 262316000084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316000085 phosphopeptide binding site; other site 262316000086 DinB superfamily; Region: DinB_2; cl00986 262316000087 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316000088 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 262316000089 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316000090 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316000091 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316000092 MULE transposase domain; Region: MULE; pfam10551 262316000093 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316000094 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316000095 active site 262316000096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316000097 Pirin-related protein [General function prediction only]; Region: COG1741 262316000098 Cupin domain; Region: Cupin_2; cl09118 262316000099 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 262316000100 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316000101 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316000102 active site 262316000103 Transcription factor WhiB; Region: Whib; pfam02467 262316000104 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316000105 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316000106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316000107 non-specific DNA binding site [nucleotide binding]; other site 262316000108 salt bridge; other site 262316000109 sequence-specific DNA binding site [nucleotide binding]; other site 262316000110 NlpC/P60 family; Region: NLPC_P60; cl11438 262316000111 Biofilm regulator BssS; Region: BssS; pfam10774 262316000112 Biofilm regulator BssS; Region: BssS; pfam10774 262316000113 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 262316000114 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 262316000115 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 262316000116 TIGR03084 family protein; Region: TIGR03084 262316000117 DinB superfamily; Region: DinB_2; cl00986 262316000118 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 262316000119 H+ Antiporter protein; Region: 2A0121; TIGR00900 262316000120 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 262316000121 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 262316000122 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 262316000123 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316000124 active site 262316000125 HIGH motif; other site 262316000126 nucleotide binding site [chemical binding]; other site 262316000127 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316000128 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316000129 active site 262316000130 KMSKS motif; other site 262316000131 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 262316000132 tRNA binding surface [nucleotide binding]; other site 262316000133 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 262316000134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000135 NAD(P) binding site [chemical binding]; other site 262316000136 active site 262316000137 Transcriptional regulators [Transcription]; Region: MarR; COG1846 262316000138 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316000139 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 262316000140 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 262316000141 Walker A/P-loop; other site 262316000142 ATP binding site [chemical binding]; other site 262316000143 Q-loop/lid; other site 262316000144 ABC transporter signature motif; other site 262316000145 Walker B; other site 262316000146 D-loop; other site 262316000147 H-loop/switch region; other site 262316000148 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 262316000149 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 262316000150 substrate binding pocket [chemical binding]; other site 262316000151 membrane-bound complex binding site; other site 262316000152 hinge residues; other site 262316000153 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 262316000154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316000155 dimer interface [polypeptide binding]; other site 262316000156 conserved gate region; other site 262316000157 putative PBP binding loops; other site 262316000158 ABC-ATPase subunit interface; other site 262316000159 Transcriptional regulators [Transcription]; Region: GntR; COG1802 262316000160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316000161 DNA-binding site [nucleotide binding]; DNA binding site 262316000162 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 262316000163 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316000164 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316000165 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316000166 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 262316000167 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 262316000168 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316000169 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 262316000170 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 262316000171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316000172 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 262316000173 Transglycosylase; Region: Transgly; cl07896 262316000174 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 262316000175 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 262316000176 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 262316000177 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 262316000178 conserved cys residue [active] 262316000179 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 262316000180 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 262316000181 dimer interface [polypeptide binding]; other site 262316000182 ssDNA binding site [nucleotide binding]; other site 262316000183 tetramer (dimer of dimers) interface [polypeptide binding]; other site 262316000184 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 262316000185 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 262316000186 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 262316000187 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 262316000188 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316000189 Walker A motif; other site 262316000190 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 262316000191 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 262316000192 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 262316000193 ATP binding site [chemical binding]; other site 262316000194 Walker B motif; other site 262316000195 DNA binding loops [nucleotide binding] 262316000196 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 262316000197 putative acyl-acceptor binding pocket; other site 262316000198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316000199 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 262316000200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000201 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316000202 Transport protein; Region: actII; TIGR00833 262316000203 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316000204 classical (c) SDRs; Region: SDR_c; cd05233 262316000205 NAD(P) binding site [chemical binding]; other site 262316000206 active site 262316000207 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 262316000208 FAD binding domain; Region: FAD_binding_4; pfam01565 262316000209 Berberine and berberine like; Region: BBE; pfam08031 262316000210 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 262316000211 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 262316000212 ligand binding site [chemical binding]; other site 262316000213 flexible hinge region; other site 262316000214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316000215 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316000216 active site 262316000217 metal binding site [ion binding]; metal-binding site 262316000218 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316000219 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316000220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262316000221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316000222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316000223 dimerization interface [polypeptide binding]; other site 262316000224 EamA-like transporter family; Region: EamA; cl01037 262316000225 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 262316000226 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316000227 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 262316000228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316000229 Domain of unknown function DUF140; Region: DUF140; cl00510 262316000230 Domain of unknown function DUF140; Region: DUF140; cl00510 262316000231 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 262316000232 4Fe-4S binding domain; Region: Fer4; cl02805 262316000233 4Fe-4S binding domain; Region: Fer4; cl02805 262316000234 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 262316000235 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 262316000236 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 262316000237 putative di-iron ligands [ion binding]; other site 262316000238 tetracycline repressor protein TetR; Provisional; Region: PRK13756 262316000239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000240 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 262316000241 CsbD-like; Region: CsbD; cl01272 262316000242 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 262316000243 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 262316000244 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316000245 MULE transposase domain; Region: MULE; pfam10551 262316000246 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 262316000247 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316000248 Int/Topo IB signature motif; other site 262316000249 active site 262316000250 DNA binding site [nucleotide binding] 262316000251 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316000252 DNA binding site [nucleotide binding] 262316000253 Int/Topo IB signature motif; other site 262316000254 active site 262316000255 Domain of unknown function DUF140; Region: DUF140; cl00510 262316000256 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 262316000257 mce related protein; Region: MCE; pfam02470 262316000258 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316000259 mce related protein; Region: MCE; pfam02470 262316000260 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316000261 mce related protein; Region: MCE; pfam02470 262316000262 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316000263 mce related protein; Region: MCE; pfam02470 262316000264 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316000265 mce related protein; Region: MCE; pfam02470 262316000266 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316000267 mce related protein; Region: MCE; pfam02470 262316000268 Mannan-binding protein; Region: MVL; pfam12151 262316000269 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 262316000270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000271 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316000272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000273 Domain of unknown function (DUF1743); Region: DUF1743; cl07202 262316000274 PPE family; Region: PPE; pfam00823 262316000275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316000276 S-adenosylmethionine binding site [chemical binding]; other site 262316000277 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316000278 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 262316000279 Sulfate transporter family; Region: Sulfate_transp; cl00967 262316000280 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316000281 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 262316000282 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 262316000283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316000285 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316000286 Condensation domain; Region: Condensation; cl09290 262316000287 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 262316000288 PhoU domain; Region: PhoU; pfam01895 262316000289 proline/glycine betaine transporter; Provisional; Region: PRK10642 262316000290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316000291 putative substrate translocation pore; other site 262316000292 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316000293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316000294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316000295 S-adenosylmethionine binding site [chemical binding]; other site 262316000296 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316000297 active site 262316000298 metal binding site [ion binding]; metal-binding site 262316000299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316000300 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 262316000301 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316000302 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 262316000303 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316000304 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316000305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316000306 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 262316000307 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316000308 Walker A/P-loop; other site 262316000309 ATP binding site [chemical binding]; other site 262316000310 Q-loop/lid; other site 262316000311 ABC transporter signature motif; other site 262316000312 Walker B; other site 262316000313 D-loop; other site 262316000314 H-loop/switch region; other site 262316000315 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 262316000316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 262316000317 substrate binding pocket [chemical binding]; other site 262316000318 membrane-bound complex binding site; other site 262316000319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 262316000320 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 262316000321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316000322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316000323 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316000324 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316000325 active site 262316000326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 262316000328 dimer interface [polypeptide binding]; other site 262316000329 phosphorylation site [posttranslational modification] 262316000330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316000331 ATP binding site [chemical binding]; other site 262316000332 Mg2+ binding site [ion binding]; other site 262316000333 G-X-G motif; other site 262316000334 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316000335 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316000336 substrate binding site [chemical binding]; other site 262316000337 oxyanion hole (OAH) forming residues; other site 262316000338 trimer interface [polypeptide binding]; other site 262316000339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316000340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000341 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 262316000342 putative dimer interface [polypeptide binding]; other site 262316000343 ligand binding site [chemical binding]; other site 262316000344 Zn binding site [ion binding]; other site 262316000345 PPE family; Region: PPE; pfam00823 262316000346 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316000347 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316000348 Proteins of 100 residues with WXG; Region: WXG100; cl02005 262316000349 Proteins of 100 residues with WXG; Region: WXG100; cl02005 262316000350 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 262316000351 secretion protein snm4; Region: sec_mycoba_snm4; TIGR02958 262316000352 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 262316000353 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 262316000354 catalytic residues [active] 262316000355 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 262316000356 active site 262316000357 catalytic residues [active] 262316000358 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 262316000359 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 262316000360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316000361 Walker A motif; other site 262316000362 ATP binding site [chemical binding]; other site 262316000363 Walker B motif; other site 262316000364 arginine finger; other site 262316000365 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316000366 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 262316000367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000368 NAD(P) binding site [chemical binding]; other site 262316000369 active site 262316000370 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 262316000371 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316000372 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 262316000373 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 262316000374 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 262316000375 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 262316000376 active site 262316000377 dimer interface [polypeptide binding]; other site 262316000378 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 262316000379 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 262316000380 active site 262316000381 FMN binding site [chemical binding]; other site 262316000382 substrate binding site [chemical binding]; other site 262316000383 3Fe-4S cluster binding site [ion binding]; other site 262316000384 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 262316000385 domain interface; other site 262316000386 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 262316000387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000388 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 262316000389 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316000390 hypothetical protein; Provisional; Region: PRK07945 262316000391 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 262316000392 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 262316000393 DNA polymerase IV; Validated; Region: PRK03858 262316000394 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 262316000395 active site 262316000396 DNA binding site [nucleotide binding] 262316000397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316000398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000399 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316000400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000401 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 262316000402 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 262316000403 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 262316000404 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 262316000405 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 262316000406 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 262316000407 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 262316000408 putative active site [active] 262316000409 catalytic site [active] 262316000410 putative metal binding site [ion binding]; other site 262316000411 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 262316000412 prephenate dehydratase; Provisional; Region: PRK11898 262316000413 Prephenate dehydratase; Region: PDT; pfam00800 262316000414 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 262316000415 putative L-Phe binding site [chemical binding]; other site 262316000416 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 262316000417 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316000418 catalytic core [active] 262316000419 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 262316000420 seryl-tRNA synthetase; Provisional; Region: PRK05431 262316000421 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 262316000422 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 262316000423 dimer interface [polypeptide binding]; other site 262316000424 active site 262316000425 motif 1; other site 262316000426 motif 2; other site 262316000427 motif 3; other site 262316000428 Cupin domain; Region: Cupin_2; cl09118 262316000429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 262316000430 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 262316000431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316000432 S-adenosylmethionine binding site [chemical binding]; other site 262316000433 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 262316000434 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 262316000435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000436 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 262316000437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000438 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316000439 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 262316000440 iron-sulfur cluster [ion binding]; other site 262316000441 [2Fe-2S] cluster binding site [ion binding]; other site 262316000442 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 262316000443 putative acyl-acceptor binding pocket; other site 262316000444 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 262316000445 putative acyl-acceptor binding pocket; other site 262316000446 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 262316000447 putative acyl-acceptor binding pocket; other site 262316000448 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 262316000449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 262316000450 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 262316000451 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 262316000452 amidase catalytic site [active] 262316000453 Zn binding residues [ion binding]; other site 262316000454 substrate binding site [chemical binding]; other site 262316000455 LGFP repeat; Region: LGFP; pfam08310 262316000456 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 262316000457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000459 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 262316000460 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 262316000461 active site 262316000462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316000463 UbiA prenyltransferase family; Region: UbiA; cl00337 262316000464 Predicted esterase [General function prediction only]; Region: COG0627 262316000465 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316000466 Predicted esterase [General function prediction only]; Region: COG0627 262316000467 Cutinase; Region: Cutinase; pfam01083 262316000468 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 262316000469 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316000470 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316000471 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 262316000472 active site 262316000473 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316000474 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316000475 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316000476 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 262316000477 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 262316000478 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316000479 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316000480 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316000481 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 262316000482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 262316000483 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316000484 active site 262316000485 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 262316000486 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316000487 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 262316000488 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316000489 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 262316000490 NSP11; Region: NSP11; pfam06471 262316000491 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 262316000492 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 262316000493 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 262316000494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316000495 DNA binding site [nucleotide binding] 262316000496 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316000497 phosphopeptide binding site; other site 262316000498 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 262316000499 DinB superfamily; Region: DinB_2; cl00986 262316000500 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 262316000501 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 262316000502 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 262316000503 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 262316000504 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262316000505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000506 NAD(P) binding site [chemical binding]; other site 262316000507 active site 262316000508 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 262316000509 FAD binding domain; Region: FAD_binding_4; pfam01565 262316000510 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 262316000511 GtrA-like protein; Region: GtrA; cl00971 262316000512 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 262316000513 C-term; Region: GreA_GreB; pfam01272 262316000514 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 262316000515 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 262316000516 ABC-2 type transporter; Region: ABC2_membrane; cl11417 262316000517 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 262316000518 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316000519 active site 262316000520 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 262316000521 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 262316000522 Walker A/P-loop; other site 262316000523 ATP binding site [chemical binding]; other site 262316000524 Q-loop/lid; other site 262316000525 ABC transporter signature motif; other site 262316000526 Walker B; other site 262316000527 D-loop; other site 262316000528 H-loop/switch region; other site 262316000529 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 262316000530 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 262316000531 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316000532 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316000533 catalytic residue [active] 262316000534 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 262316000535 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 262316000536 NAD(P) binding site [chemical binding]; other site 262316000537 peptide chain release factor eRF/aRF, subunit 1; Region: eRF; TIGR00108 262316000538 peptide chain release factor 1; Provisional; Region: PRK04011 262316000539 eRF1 domain 3; Region: eRF1_3; pfam03465 262316000540 Beta-lactamase; Region: Beta-lactamase; cl01009 262316000541 enoyl-CoA hydratase; Provisional; Region: PRK06142 262316000542 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316000543 substrate binding site [chemical binding]; other site 262316000544 oxyanion hole (OAH) forming residues; other site 262316000545 trimer interface [polypeptide binding]; other site 262316000546 TIGR03086 family protein; Region: TIGR03086 262316000547 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 262316000548 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316000549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316000550 homodimer interface [polypeptide binding]; other site 262316000551 catalytic residue [active] 262316000552 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 262316000553 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262316000554 Integrase core domain; Region: rve; cl01316 262316000555 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 262316000556 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 262316000557 putative active site [active] 262316000558 putative substrate binding site [chemical binding]; other site 262316000559 ATP binding site [chemical binding]; other site 262316000560 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316000561 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316000562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316000563 active site 262316000564 phosphorylation site [posttranslational modification] 262316000565 intermolecular recognition site; other site 262316000566 dimerization interface [polypeptide binding]; other site 262316000567 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 262316000568 DNA binding site [nucleotide binding] 262316000569 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 262316000570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 262316000571 dimer interface [polypeptide binding]; other site 262316000572 phosphorylation site [posttranslational modification] 262316000573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316000574 ATP binding site [chemical binding]; other site 262316000575 Mg2+ binding site [ion binding]; other site 262316000576 G-X-G motif; other site 262316000577 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 262316000578 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 262316000579 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316000580 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 262316000581 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 262316000582 NAD(P) binding site [chemical binding]; other site 262316000583 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 262316000584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000585 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316000586 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316000587 active site 262316000588 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 262316000589 classical (c) SDRs; Region: SDR_c; cd05233 262316000590 NAD(P) binding site [chemical binding]; other site 262316000591 active site 262316000592 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 262316000593 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 262316000594 putative active site [active] 262316000595 putative substrate binding site [chemical binding]; other site 262316000596 ATP binding site [chemical binding]; other site 262316000597 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316000598 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 262316000599 catalytic core [active] 262316000600 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 262316000601 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 262316000602 putative active site [active] 262316000603 putative substrate binding site [chemical binding]; other site 262316000604 ATP binding site [chemical binding]; other site 262316000605 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 262316000606 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 262316000607 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316000608 Walker A/P-loop; other site 262316000609 ATP binding site [chemical binding]; other site 262316000610 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316000611 ABC transporter signature motif; other site 262316000612 Walker B; other site 262316000613 D-loop; other site 262316000614 H-loop/switch region; other site 262316000615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 262316000616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 262316000617 Protein of unknown function (DUF1089); Region: DUF1089; cl01425 262316000618 prephenate dehydrogenase; Validated; Region: PRK06545 262316000619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000620 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 262316000621 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 262316000622 nucleoside/Zn binding site; other site 262316000623 dimer interface [polypeptide binding]; other site 262316000624 catalytic motif [active] 262316000625 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 262316000626 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 262316000627 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 262316000628 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895 262316000629 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 262316000630 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316000631 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 262316000632 active site 262316000633 metal binding site [ion binding]; metal-binding site 262316000634 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316000635 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316000636 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 262316000637 pyruvate carboxylase; Reviewed; Region: PRK12999 262316000638 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316000639 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316000640 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 262316000641 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 262316000642 active site 262316000643 catalytic residues [active] 262316000644 metal binding site [ion binding]; metal-binding site 262316000645 homodimer binding site [polypeptide binding]; other site 262316000646 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 262316000647 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 262316000648 carboxyltransferase (CT) interaction site; other site 262316000649 biotinylation site [posttranslational modification]; other site 262316000650 citrate synthase; Provisional; Region: PRK14033 262316000651 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA...; Region: DsCS_like; cd06111 262316000652 dimer interface [polypeptide binding]; other site 262316000653 active site 262316000654 citrylCoA binding site [chemical binding]; other site 262316000655 oxalacetate/citrate binding site [chemical binding]; other site 262316000656 coenzyme A binding site [chemical binding]; other site 262316000657 catalytic triad [active] 262316000658 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 262316000659 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 262316000660 tetramer interface [polypeptide binding]; other site 262316000661 active site 262316000662 Mg2+/Mn2+ binding site [ion binding]; other site 262316000663 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 262316000664 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262316000665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316000666 non-specific DNA binding site [nucleotide binding]; other site 262316000667 salt bridge; other site 262316000668 sequence-specific DNA binding site [nucleotide binding]; other site 262316000669 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 262316000670 Domain of unknown function (DUF955); Region: DUF955; cl01076 262316000671 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 262316000672 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 262316000673 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 262316000674 substrate binding site [chemical binding]; other site 262316000675 dimer interface [polypeptide binding]; other site 262316000676 ATP binding site [chemical binding]; other site 262316000677 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 262316000678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316000679 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 262316000680 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316000681 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316000682 catalytic residue [active] 262316000683 probable methyltransferase; Region: TIGR03438 262316000684 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 262316000685 TIGR03442 family protein; Region: TIGR03442 262316000686 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 262316000687 putative active site [active] 262316000688 putative dimer interface [polypeptide binding]; other site 262316000689 DinB superfamily; Region: DinB_2; cl00986 262316000690 TIGR03440 family protein; Region: unchr_TIGR03440 262316000691 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 262316000692 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 262316000693 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 262316000694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000695 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 262316000696 aspartate kinase; Reviewed; Region: PRK06635 262316000697 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 262316000698 putative nucleotide binding site [chemical binding]; other site 262316000699 putative catalytic residues [active] 262316000700 putative Mg ion binding site [ion binding]; other site 262316000701 putative aspartate binding site [chemical binding]; other site 262316000702 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 262316000703 putative allosteric regulatory site; other site 262316000704 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 262316000705 putative allosteric regulatory residue; other site 262316000706 2-isopropylmalate synthase; Validated; Region: PRK03739 262316000707 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 262316000708 active site 262316000709 catalytic residues [active] 262316000710 metal binding site [ion binding]; metal-binding site 262316000711 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 262316000712 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 262316000713 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 262316000714 active site 262316000715 substrate binding site [chemical binding]; other site 262316000716 catalytic site [active] 262316000717 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cl00038 262316000718 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 262316000719 catalytic triad [active] 262316000720 recombination protein RecR; Reviewed; Region: recR; PRK00076 262316000721 RecR protein; Region: RecR; pfam02132 262316000722 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 262316000723 putative active site [active] 262316000724 putative metal-binding site [ion binding]; other site 262316000725 tetramer interface [polypeptide binding]; other site 262316000726 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 262316000727 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 262316000728 active site 262316000729 metal binding site [ion binding]; metal-binding site 262316000730 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 262316000731 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 262316000732 FAD binding domain; Region: FAD_binding_4; pfam01565 262316000733 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316000734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316000735 S-adenosylmethionine binding site [chemical binding]; other site 262316000736 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 262316000737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316000738 Walker A motif; other site 262316000739 ATP binding site [chemical binding]; other site 262316000740 Walker B motif; other site 262316000741 arginine finger; other site 262316000742 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 262316000743 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 262316000744 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316000745 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316000746 catalytic residue [active] 262316000747 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 262316000748 CHAT domain; Region: CHAT; cl02083 262316000749 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316000750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000751 Cutinase; Region: Cutinase; pfam01083 262316000752 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 262316000753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000754 NAD(P) binding site [chemical binding]; other site 262316000755 active site 262316000756 TetR family transcriptional regulator; Provisional; Region: PRK14996 262316000757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000758 Cytochrome P450; Region: p450; cl12078 262316000759 Transposase domain (DUF772); Region: DUF772; cl12084 262316000760 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 262316000761 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 262316000762 nucleotide binding site [chemical binding]; other site 262316000763 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 262316000764 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 262316000765 active site 262316000766 DNA binding site [nucleotide binding] 262316000767 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 262316000768 DNA binding site [nucleotide binding] 262316000769 Cytochrome P450; Region: p450; cl12078 262316000770 haloalkane dehalogenase; Provisional; Region: PRK00870 262316000771 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 262316000772 nudix motif; other site 262316000773 Condensation domain; Region: Condensation; cl09290 262316000774 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316000775 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 262316000776 classical (c) SDRs; Region: SDR_c; cd05233 262316000777 NAD(P) binding site [chemical binding]; other site 262316000778 active site 262316000779 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316000780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000781 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316000782 classical (c) SDRs; Region: SDR_c; cd05233 262316000783 NAD(P) binding site [chemical binding]; other site 262316000784 active site 262316000785 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 262316000786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000788 glycerol kinase; Provisional; Region: glpK; PRK00047 262316000789 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 262316000790 N- and C-terminal domain interface [polypeptide binding]; other site 262316000791 active site 262316000792 MgATP binding site [chemical binding]; other site 262316000793 catalytic site [active] 262316000794 metal binding site [ion binding]; metal-binding site 262316000795 carbohydrate binding site [chemical binding]; other site 262316000796 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316000797 RDD family; Region: RDD; cl00746 262316000798 Integral membrane protein DUF95; Region: DUF95; cl00572 262316000799 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 262316000800 Protein of unknown function DUF58; Region: DUF58; pfam01882 262316000801 MoxR-like ATPases [General function prediction only]; Region: COG0714 262316000802 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316000803 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 262316000804 GatB domain; Region: GatB_Yqey; cl11497 262316000805 SelB subfamily. SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of...; Region: SelB; cd04171 262316000806 G1 box; other site 262316000807 putative GEF interaction site [polypeptide binding]; other site 262316000808 GTP/Mg2+ binding site [chemical binding]; other site 262316000809 Switch I region; other site 262316000810 G2 box; other site 262316000811 G3 box; other site 262316000812 Switch II region; other site 262316000813 G4 box; other site 262316000814 G5 box; other site 262316000815 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 262316000816 selenocysteine synthase; Provisional; Region: PRK04311 262316000817 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316000818 selenocysteine synthase; Provisional; Region: PRK04311 262316000819 selenophosphate synthetase; Provisional; Region: PRK00943 262316000820 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 262316000821 dimerization interface [polypeptide binding]; other site 262316000822 putative ATP binding site [chemical binding]; other site 262316000823 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 262316000824 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 262316000825 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 262316000826 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 262316000827 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929 262316000828 molybdopterin cofactor binding site; other site 262316000829 Fe-S containing; Region: FDH-beta; TIGR01582 262316000830 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316000831 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 262316000832 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 262316000833 proposed catalytic triad [active] 262316000834 conserved cys residue [active] 262316000835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316000836 S-adenosylmethionine binding site [chemical binding]; other site 262316000837 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 262316000838 PAS domain S-box; Region: sensory_box; TIGR00229 262316000839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262316000840 putative active site [active] 262316000841 heme pocket [chemical binding]; other site 262316000842 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 262316000843 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 262316000844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316000845 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 262316000846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316000847 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 262316000848 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 262316000849 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316000850 anti sigma factor interaction site; other site 262316000851 regulatory phosphorylation site [posttranslational modification]; other site 262316000852 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 262316000853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 262316000854 motif II; other site 262316000855 Restriction endonuclease; Region: Mrr_cat; cl00747 262316000856 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 262316000857 GAF domain; Region: GAF; cl00853 262316000858 ANTAR domain; Region: ANTAR; cl04297 262316000859 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 262316000860 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 262316000861 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 262316000862 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316000863 catalytic residue [active] 262316000864 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 262316000865 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 262316000866 putative active site [active] 262316000867 putative metal binding site [ion binding]; other site 262316000868 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 262316000869 Transglycosylase; Region: Transgly; cl07896 262316000870 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 262316000871 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 262316000872 Transcription factor WhiB; Region: Whib; pfam02467 262316000873 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 262316000874 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 262316000875 DTAP/Switch II; other site 262316000876 Switch I; other site 262316000877 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 262316000878 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 262316000879 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 262316000880 P loop; other site 262316000881 Nucleotide binding site [chemical binding]; other site 262316000882 DTAP/Switch II; other site 262316000883 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 262316000884 homotrimer interaction site [polypeptide binding]; other site 262316000885 putative active site [active] 262316000886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316000887 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 262316000888 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 262316000889 ligand binding site [chemical binding]; other site 262316000890 flexible hinge region; other site 262316000891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316000892 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 262316000893 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 262316000894 minor groove reading motif; other site 262316000895 helix-hairpin-helix signature motif; other site 262316000896 substrate binding pocket [chemical binding]; other site 262316000897 active site 262316000898 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 262316000899 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 262316000900 catalytic residues [active] 262316000901 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 262316000902 putative active site [active] 262316000903 putative CoA binding site [chemical binding]; other site 262316000904 nudix motif; other site 262316000905 metal binding site [ion binding]; metal-binding site 262316000906 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 262316000907 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316000908 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 262316000909 acetyl-CoA synthetase; Provisional; Region: PRK00174 262316000910 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 262316000911 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316000912 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 262316000913 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 262316000914 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 262316000915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316000916 dimer interface [polypeptide binding]; other site 262316000917 conserved gate region; other site 262316000918 ABC-ATPase subunit interface; other site 262316000919 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 262316000920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316000921 dimer interface [polypeptide binding]; other site 262316000922 conserved gate region; other site 262316000923 putative PBP binding loops; other site 262316000924 ABC-ATPase subunit interface; other site 262316000925 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 262316000926 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 262316000927 Walker A/P-loop; other site 262316000928 ATP binding site [chemical binding]; other site 262316000929 Q-loop/lid; other site 262316000930 ABC transporter signature motif; other site 262316000931 Walker B; other site 262316000932 D-loop; other site 262316000933 H-loop/switch region; other site 262316000934 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 262316000935 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 262316000936 Walker A/P-loop; other site 262316000937 ATP binding site [chemical binding]; other site 262316000938 Q-loop/lid; other site 262316000939 ABC transporter signature motif; other site 262316000940 Walker B; other site 262316000941 D-loop; other site 262316000942 H-loop/switch region; other site 262316000943 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 262316000944 Fic family protein [Function unknown]; Region: COG3177 262316000945 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 262316000946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 262316000947 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 262316000948 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 262316000949 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 262316000950 hexamer interface [polypeptide binding]; other site 262316000951 Walker B motif; other site 262316000952 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 262316000953 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 262316000954 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316000955 ATP binding site [chemical binding]; other site 262316000956 putative Mg++ binding site [ion binding]; other site 262316000957 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316000958 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 262316000959 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 262316000960 DNA-binding site [nucleotide binding]; DNA binding site 262316000961 RNA-binding motif; other site 262316000962 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 262316000963 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 262316000964 active site 262316000965 interdomain interaction site; other site 262316000966 putative metal-binding site [ion binding]; other site 262316000967 nucleotide binding site [chemical binding]; other site 262316000968 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 262316000969 domain I; other site 262316000970 phosphate binding site [ion binding]; other site 262316000971 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 262316000972 domain II; other site 262316000973 domain III; other site 262316000974 nucleotide binding site [chemical binding]; other site 262316000975 DNA binding groove [nucleotide binding] 262316000976 catalytic site [active] 262316000977 domain IV; other site 262316000978 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 262316000979 cyclase homology domain; Region: CHD; cd07302 262316000980 nucleotidyl binding site; other site 262316000981 metal binding site [ion binding]; metal-binding site 262316000982 dimer interface [polypeptide binding]; other site 262316000983 DNA polymerase III subunit delta'; Validated; Region: PRK07940 262316000984 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316000985 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262316000986 Integrase core domain; Region: rve; cl01316 262316000987 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316000988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000989 NAD(P) binding site [chemical binding]; other site 262316000990 active site 262316000991 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 262316000992 Ligand binding site [chemical binding]; other site 262316000993 Putative Catalytic site [active] 262316000994 DXD motif; other site 262316000995 Integral membrane protein TerC family; Region: TerC; cl10468 262316000996 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 262316000997 dimer interface [polypeptide binding]; other site 262316000998 substrate binding site [chemical binding]; other site 262316000999 metal binding sites [ion binding]; metal-binding site 262316001000 PBP4 family; Region: PBP4; TIGR00666 262316001001 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 262316001002 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 262316001003 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 262316001004 Ligand Binding Site [chemical binding]; other site 262316001005 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 262316001006 Protein of unknown function (DUF541); Region: SIMPL; cl01077 262316001007 PE family; Region: PE; pfam00934 262316001008 PPE family; Region: PPE; pfam00823 262316001009 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316001010 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316001011 active site 262316001012 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262316001013 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 262316001014 putative NAD(P) binding site [chemical binding]; other site 262316001015 catalytic Zn binding site [ion binding]; other site 262316001016 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316001017 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 262316001018 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316001019 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316001020 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 262316001021 dimer interface [polypeptide binding]; other site 262316001022 metal binding site [ion binding]; metal-binding site 262316001023 FtsH Extracellular; Region: FtsH_ext; pfam06480 262316001024 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 262316001025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316001026 Walker A motif; other site 262316001027 ATP binding site [chemical binding]; other site 262316001028 Walker B motif; other site 262316001029 arginine finger; other site 262316001030 Peptidase family M41; Region: Peptidase_M41; pfam01434 262316001031 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 262316001032 homodecamer interface [polypeptide binding]; other site 262316001033 GTP cyclohydrolase I; Provisional; Region: PLN03044 262316001034 active site 262316001035 putative catalytic site residues [active] 262316001036 zinc binding site [ion binding]; other site 262316001037 GTP-CH-I/GFRP interaction surface; other site 262316001038 dihydropteroate synthase; Region: DHPS; TIGR01496 262316001039 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 262316001040 substrate binding pocket [chemical binding]; other site 262316001041 dimer interface [polypeptide binding]; other site 262316001042 inhibitor binding site; inhibition site 262316001043 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 262316001044 homooctamer interface [polypeptide binding]; other site 262316001045 active site 262316001046 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 262316001047 catalytic center binding site [active] 262316001048 ATP binding site [chemical binding]; other site 262316001049 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 262316001050 Uncharacterized conserved protein [Function unknown]; Region: COG5495 262316001051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001052 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 262316001053 Pantoate-beta-alanine ligase; Region: PanC; cd00560 262316001054 pantoate--beta-alanine ligase; Region: panC; TIGR00018 262316001055 active site 262316001056 ATP-binding site [chemical binding]; other site 262316001057 pantoate-binding site; other site 262316001058 HXXH motif; other site 262316001059 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 262316001060 tetramerization interface [polypeptide binding]; other site 262316001061 active site 262316001062 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 262316001063 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 262316001064 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 262316001065 dimer interface [polypeptide binding]; other site 262316001066 putative anticodon binding site; other site 262316001067 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262316001068 motif 1; other site 262316001069 dimer interface [polypeptide binding]; other site 262316001070 active site 262316001071 motif 2; other site 262316001072 motif 3; other site 262316001073 Lsr2; Region: Lsr2; pfam11774 262316001074 Clp protease ATP binding subunit; Region: clpC; CHL00095 262316001075 Clp amino terminal domain; Region: Clp_N; pfam02861 262316001076 Clp amino terminal domain; Region: Clp_N; pfam02861 262316001077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316001078 Walker A motif; other site 262316001079 ATP binding site [chemical binding]; other site 262316001080 Walker B motif; other site 262316001081 arginine finger; other site 262316001082 UvrB/uvrC motif; Region: UVR; pfam02151 262316001083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316001084 Walker A motif; other site 262316001085 ATP binding site [chemical binding]; other site 262316001086 Walker B motif; other site 262316001087 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 262316001088 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 262316001089 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316001090 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 262316001091 catalytic core [active] 262316001092 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 262316001093 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 262316001094 Beta-lactamase; Region: Beta-lactamase; cl01009 262316001095 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 262316001096 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316001097 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 262316001098 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 262316001099 minor groove reading motif; other site 262316001100 helix-hairpin-helix signature motif; other site 262316001101 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 262316001102 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 262316001103 active site clefts [active] 262316001104 zinc binding site [ion binding]; other site 262316001105 dimer interface [polypeptide binding]; other site 262316001106 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 262316001107 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 262316001108 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 262316001109 DNA repair protein RadA; Provisional; Region: PRK11823 262316001110 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316001111 Walker A motif; other site 262316001112 ATP binding site [chemical binding]; other site 262316001113 Walker B motif; other site 262316001114 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 262316001115 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 262316001116 substrate binding site [chemical binding]; other site 262316001117 dimer interface [polypeptide binding]; other site 262316001118 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 262316001119 homotrimer interaction site [polypeptide binding]; other site 262316001120 zinc binding site [ion binding]; other site 262316001121 CDP-binding sites; other site 262316001122 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 262316001123 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316001124 active site 262316001125 HIGH motif; other site 262316001126 nucleotide binding site [chemical binding]; other site 262316001127 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 262316001128 KMSKS motif; other site 262316001129 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 262316001130 tRNA binding surface [nucleotide binding]; other site 262316001131 anticodon binding site; other site 262316001132 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 262316001133 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 262316001134 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 262316001135 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 262316001136 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 262316001137 active site 262316001138 catalytic site [active] 262316001139 metal binding site [ion binding]; metal-binding site 262316001140 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 262316001141 Predicted ATPase [General function prediction only]; Region: COG3899 262316001142 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 262316001143 DNA binding residues [nucleotide binding] 262316001144 dimerization interface [polypeptide binding]; other site 262316001145 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 262316001146 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 262316001147 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316001148 LamB/YcsF family; Region: LamB_YcsF; cl00664 262316001149 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 262316001150 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 262316001151 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316001152 Walker A/P-loop; other site 262316001153 ATP binding site [chemical binding]; other site 262316001154 Q-loop/lid; other site 262316001155 ABC transporter signature motif; other site 262316001156 Walker B; other site 262316001157 D-loop; other site 262316001158 H-loop/switch region; other site 262316001159 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 262316001160 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 262316001161 intersubunit interface [polypeptide binding]; other site 262316001162 Transcriptional regulators [Transcription]; Region: PurR; COG1609 262316001163 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 262316001164 DNA binding site [nucleotide binding] 262316001165 domain linker motif; other site 262316001166 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 262316001167 putative dimerization interface [polypeptide binding]; other site 262316001168 putative ligand binding site [chemical binding]; other site 262316001169 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001171 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001172 active site 262316001173 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001174 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001175 active site 262316001176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001177 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 262316001178 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316001179 putative NAD(P) binding site [chemical binding]; other site 262316001180 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 262316001181 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 262316001182 FAD binding pocket [chemical binding]; other site 262316001183 FAD binding motif [chemical binding]; other site 262316001184 phosphate binding motif [ion binding]; other site 262316001185 beta-alpha-beta structure motif; other site 262316001186 NAD(p) ribose binding residues [chemical binding]; other site 262316001187 NAD binding pocket [chemical binding]; other site 262316001188 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 262316001189 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316001190 catalytic loop [active] 262316001191 iron binding site [ion binding]; other site 262316001192 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001193 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 262316001194 Flavin binding site [chemical binding]; other site 262316001195 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 262316001196 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 262316001197 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 262316001198 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 262316001199 active site 262316001200 Fe binding site [ion binding]; other site 262316001201 Flavin Reductases; Region: FlaRed; cl00801 262316001202 N-acetyltransferase; Region: Acetyltransf_2; cl00949 262316001203 aspartate aminotransferase; Provisional; Region: PRK08361 262316001204 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316001205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316001206 homodimer interface [polypeptide binding]; other site 262316001207 catalytic residue [active] 262316001208 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001209 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316001210 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001211 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316001212 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001213 active site 262316001214 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001215 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001216 active site 262316001217 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 262316001218 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316001219 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 262316001220 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001221 active site 262316001222 short chain dehydrogenase; Provisional; Region: PRK07831 262316001223 classical (c) SDRs; Region: SDR_c; cd05233 262316001224 NAD(P) binding site [chemical binding]; other site 262316001225 active site 262316001226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001227 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 262316001228 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 262316001229 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316001230 dimer interface [polypeptide binding]; other site 262316001231 active site 262316001232 Nitronate monooxygenase; Region: NMO; pfam03060 262316001233 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 262316001234 FMN binding site [chemical binding]; other site 262316001235 substrate binding site [chemical binding]; other site 262316001236 putative catalytic residue [active] 262316001237 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 262316001238 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 262316001239 enoyl-CoA hydratase; Provisional; Region: PRK07938 262316001240 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316001241 substrate binding site [chemical binding]; other site 262316001242 oxyanion hole (OAH) forming residues; other site 262316001243 trimer interface [polypeptide binding]; other site 262316001244 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316001245 classical (c) SDRs; Region: SDR_c; cd05233 262316001246 NAD(P) binding site [chemical binding]; other site 262316001247 active site 262316001248 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 262316001249 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 262316001250 homodimer interface [polypeptide binding]; other site 262316001251 NAD binding site [chemical binding]; other site 262316001252 active site 262316001253 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316001254 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 262316001255 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316001256 dimer interface [polypeptide binding]; other site 262316001257 active site 262316001258 Cytochrome P450; Region: p450; cl12078 262316001259 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001260 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316001261 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001262 active site 262316001263 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001264 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001265 active site 262316001266 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 262316001267 active site 262316001268 catalytic site [active] 262316001269 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 262316001270 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316001271 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 262316001272 putative active site [active] 262316001273 putative catalytic site [active] 262316001274 lipid-transfer protein; Provisional; Region: PRK07855 262316001275 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316001276 active site 262316001277 enoyl-CoA hydratase; Region: PLN02864 262316001278 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 262316001279 dimer interaction site [polypeptide binding]; other site 262316001280 substrate-binding tunnel; other site 262316001281 active site 262316001282 catalytic site [active] 262316001283 substrate binding site [chemical binding]; other site 262316001284 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 262316001285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001286 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 262316001287 acetaldehyde dehydrogenase; Validated; Region: PRK08300 262316001288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001289 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 262316001290 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 262316001291 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 262316001292 active site 262316001293 catalytic residues [active] 262316001294 metal binding site [ion binding]; metal-binding site 262316001295 DmpG-like communication domain; Region: DmpG_comm; pfam07836 262316001296 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 262316001297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001298 NAD(P) binding site [chemical binding]; other site 262316001299 active site 262316001300 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 262316001301 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 262316001302 trimer interface [polypeptide binding]; other site 262316001303 putative metal binding site [ion binding]; other site 262316001304 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316001305 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 262316001306 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316001307 active site 262316001308 lipid-transfer protein; Provisional; Region: PRK07937 262316001309 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316001310 active site 262316001311 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 262316001312 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316001313 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 262316001314 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316001315 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316001316 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 262316001317 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 262316001318 Cytochrome P450; Region: p450; cl12078 262316001319 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 262316001320 putative active site [active] 262316001321 enoyl-CoA hydratase; Provisional; Region: PRK07799 262316001322 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316001323 substrate binding site [chemical binding]; other site 262316001324 oxyanion hole (OAH) forming residues; other site 262316001325 trimer interface [polypeptide binding]; other site 262316001326 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316001327 acyl-CoA synthetase; Validated; Region: PRK07798 262316001328 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316001329 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316001330 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316001331 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316001332 PYR/PP interface [polypeptide binding]; other site 262316001333 dimer interface [polypeptide binding]; other site 262316001334 TPP binding site [chemical binding]; other site 262316001335 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 262316001336 TPP-binding site [chemical binding]; other site 262316001337 acyl-CoA synthetase; Validated; Region: PRK07867 262316001338 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316001339 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316001340 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001341 active site 262316001342 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001343 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 262316001344 FAD binding site [chemical binding]; other site 262316001345 substrate binding site [chemical binding]; other site 262316001346 catalytic base [active] 262316001347 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 262316001348 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 262316001349 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 262316001350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001351 NAD(P) binding site [chemical binding]; other site 262316001352 active site 262316001353 Domain of unknown function DUF140; Region: DUF140; cl00510 262316001354 Domain of unknown function DUF140; Region: DUF140; cl00510 262316001355 mce related protein; Region: MCE; pfam02470 262316001356 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316001357 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001358 mce related protein; Region: MCE; pfam02470 262316001359 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001360 mce related protein; Region: MCE; pfam02470 262316001361 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 262316001362 mce related protein; Region: MCE; pfam02470 262316001363 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001364 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001365 mce related protein; Region: MCE; pfam02470 262316001366 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001367 mce related protein; Region: MCE; pfam02470 262316001368 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 262316001369 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 262316001370 active site 262316001371 homotetramer interface [polypeptide binding]; other site 262316001372 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 262316001373 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 262316001374 Walker A/P-loop; other site 262316001375 ATP binding site [chemical binding]; other site 262316001376 Q-loop/lid; other site 262316001377 ABC transporter signature motif; other site 262316001378 Walker B; other site 262316001379 D-loop; other site 262316001380 H-loop/switch region; other site 262316001381 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 262316001382 enoyl-CoA hydratase; Provisional; Region: PRK08290 262316001383 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316001384 substrate binding site [chemical binding]; other site 262316001385 oxyanion hole (OAH) forming residues; other site 262316001386 trimer interface [polypeptide binding]; other site 262316001387 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316001388 classical (c) SDRs; Region: SDR_c; cd05233 262316001389 NAD(P) binding site [chemical binding]; other site 262316001390 active site 262316001391 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316001392 classical (c) SDRs; Region: SDR_c; cd05233 262316001393 NAD(P) binding site [chemical binding]; other site 262316001394 active site 262316001395 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 262316001396 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 262316001397 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 262316001398 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316001399 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316001400 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 262316001401 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 262316001402 N-acetyl-D-glucosamine binding site [chemical binding]; other site 262316001403 catalytic residue [active] 262316001404 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316001405 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262316001406 Integrase core domain; Region: rve; cl01316 262316001407 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316001408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316001409 active site 262316001410 phosphorylation site [posttranslational modification] 262316001411 intermolecular recognition site; other site 262316001412 dimerization interface [polypeptide binding]; other site 262316001413 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 262316001414 DNA binding site [nucleotide binding] 262316001415 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 262316001416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 262316001417 dimer interface [polypeptide binding]; other site 262316001418 phosphorylation site [posttranslational modification] 262316001419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316001420 ATP binding site [chemical binding]; other site 262316001421 Mg2+ binding site [ion binding]; other site 262316001422 G-X-G motif; other site 262316001423 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 262316001424 nucleotide binding site/active site [active] 262316001425 HIT family signature motif; other site 262316001426 catalytic residue [active] 262316001427 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316001428 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 262316001429 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 262316001430 NAD binding site [chemical binding]; other site 262316001431 catalytic Zn binding site [ion binding]; other site 262316001432 substrate binding site [chemical binding]; other site 262316001433 structural Zn binding site [ion binding]; other site 262316001434 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 262316001435 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 262316001436 Cytochrome P450; Region: p450; cl12078 262316001437 short chain dehydrogenase; Provisional; Region: PRK12939 262316001438 classical (c) SDRs; Region: SDR_c; cd05233 262316001439 NAD(P) binding site [chemical binding]; other site 262316001440 active site 262316001441 Cytochrome P450; Region: p450; cl12078 262316001442 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316001443 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 262316001444 NAD binding site [chemical binding]; other site 262316001445 catalytic residues [active] 262316001446 classical (c) SDRs; Region: SDR_c; cd05233 262316001447 NAD(P) binding site [chemical binding]; other site 262316001448 active site 262316001449 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 262316001450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001451 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 262316001452 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316001453 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 262316001454 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 262316001455 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316001456 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 262316001457 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 262316001458 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 262316001459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 262316001460 Protein of unknown function (DUF429); Region: DUF429; cl12046 262316001461 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 262316001462 adenylosuccinate lyase; Region: purB; TIGR00928 262316001463 tetramer interface [polypeptide binding]; other site 262316001464 Cytochrome P450; Region: p450; cl12078 262316001465 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 262316001466 ATP binding site [chemical binding]; other site 262316001467 active site 262316001468 substrate binding site [chemical binding]; other site 262316001469 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 262316001470 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316001471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001472 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262316001473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316001474 putative substrate translocation pore; other site 262316001475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316001476 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 262316001477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316001478 putative substrate translocation pore; other site 262316001479 Predicted deacetylase [General function prediction only]; Region: COG3233 262316001480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001481 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316001482 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 262316001483 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 262316001484 putative active site [active] 262316001485 catalytic triad [active] 262316001486 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 262316001487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316001488 DNA-binding site [nucleotide binding]; DNA binding site 262316001489 UTRA domain; Region: UTRA; cl01230 262316001490 Cupin domain; Region: Cupin_2; cl09118 262316001491 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 262316001492 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 262316001493 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 262316001494 active site 262316001495 metal binding site [ion binding]; metal-binding site 262316001496 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316001497 active site 262316001498 metal binding site [ion binding]; metal-binding site 262316001499 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 262316001500 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 262316001501 dimerization interface [polypeptide binding]; other site 262316001502 ATP binding site [chemical binding]; other site 262316001503 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 262316001504 dimerization interface [polypeptide binding]; other site 262316001505 ATP binding site [chemical binding]; other site 262316001506 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 262316001507 amidophosphoribosyltransferase; Provisional; Region: PRK07847 262316001508 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 262316001509 active site 262316001510 tetramer interface [polypeptide binding]; other site 262316001511 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 262316001512 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 262316001513 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 262316001514 dimerization interface [polypeptide binding]; other site 262316001515 putative ATP binding site [chemical binding]; other site 262316001516 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 262316001517 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 262316001518 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 262316001519 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 262316001520 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 262316001521 Aminotransferase class IV; Region: Aminotran_4; pfam01063 262316001522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316001523 catalytic residue [active] 262316001524 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 262316001525 heme-binding site [chemical binding]; other site 262316001526 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 262316001527 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 262316001528 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 262316001529 active site residue [active] 262316001530 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 262316001531 active site residue [active] 262316001532 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262316001533 catalytic residues [active] 262316001534 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316001535 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 262316001536 DNA binding site [nucleotide binding] 262316001537 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 262316001538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316001539 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316001540 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 262316001541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316001542 dimer interface [polypeptide binding]; other site 262316001543 conserved gate region; other site 262316001544 putative PBP binding loops; other site 262316001545 ABC-ATPase subunit interface; other site 262316001546 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 262316001547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316001548 dimer interface [polypeptide binding]; other site 262316001549 conserved gate region; other site 262316001550 putative PBP binding loops; other site 262316001551 ABC-ATPase subunit interface; other site 262316001552 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 262316001553 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 262316001554 Walker A/P-loop; other site 262316001555 ATP binding site [chemical binding]; other site 262316001556 Q-loop/lid; other site 262316001557 ABC transporter signature motif; other site 262316001558 Walker B; other site 262316001559 D-loop; other site 262316001560 H-loop/switch region; other site 262316001561 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 262316001562 PhoU domain; Region: PhoU; pfam01895 262316001563 PhoU domain; Region: PhoU; pfam01895 262316001564 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 262316001565 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 262316001566 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 262316001567 FMN binding site [chemical binding]; other site 262316001568 active site 262316001569 catalytic residues [active] 262316001570 substrate binding site [chemical binding]; other site 262316001571 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 262316001572 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 262316001573 homodimer interface [polypeptide binding]; other site 262316001574 putative substrate binding pocket [chemical binding]; other site 262316001575 diiron center [ion binding]; other site 262316001576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001577 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 262316001578 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262316001579 dimerization interface [polypeptide binding]; other site 262316001580 putative DNA binding site [nucleotide binding]; other site 262316001581 putative Zn2+ binding site [ion binding]; other site 262316001582 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 262316001583 nucleoside/Zn binding site; other site 262316001584 dimer interface [polypeptide binding]; other site 262316001585 catalytic motif [active] 262316001586 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316001587 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262316001588 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 262316001589 Integrase core domain; Region: rve; cl01316 262316001590 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316001591 classical (c) SDRs; Region: SDR_c; cd05233 262316001592 NAD(P) binding site [chemical binding]; other site 262316001593 active site 262316001594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001595 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 262316001596 Cytochrome P450; Region: p450; cl12078 262316001597 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 262316001598 DNA-binding site [nucleotide binding]; DNA binding site 262316001599 RNA-binding motif; other site 262316001600 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 262316001601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316001602 S-adenosylmethionine binding site [chemical binding]; other site 262316001603 short chain dehydrogenase; Provisional; Region: PRK08278 262316001604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001605 NAD(P) binding site [chemical binding]; other site 262316001606 active site 262316001607 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 262316001608 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 262316001609 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 262316001610 B12 binding site [chemical binding]; other site 262316001611 cobalt ligand [ion binding]; other site 262316001612 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 262316001613 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316001614 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316001615 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316001616 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316001617 catalytic loop [active] 262316001618 iron binding site [ion binding]; other site 262316001619 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 262316001620 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316001621 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001622 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001623 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001624 active site 262316001625 enoyl-CoA hydratase; Provisional; Region: PRK07327 262316001626 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316001627 substrate binding site [chemical binding]; other site 262316001628 oxyanion hole (OAH) forming residues; other site 262316001629 trimer interface [polypeptide binding]; other site 262316001630 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 262316001631 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 262316001632 putative acyltransferase; Provisional; Region: PRK05790 262316001633 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316001634 dimer interface [polypeptide binding]; other site 262316001635 active site 262316001636 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 262316001637 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 262316001638 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 262316001639 TPP-binding site [chemical binding]; other site 262316001640 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262316001641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316001642 active site 262316001643 phosphorylation site [posttranslational modification] 262316001644 intermolecular recognition site; other site 262316001645 dimerization interface [polypeptide binding]; other site 262316001646 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 262316001647 DNA binding residues [nucleotide binding] 262316001648 dimerization interface [polypeptide binding]; other site 262316001649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 262316001650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316001651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001652 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 262316001653 Transcriptional regulator [Transcription]; Region: IclR; COG1414 262316001654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316001655 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316001656 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316001657 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 262316001658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001659 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 262316001660 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 262316001661 putative active site [active] 262316001662 Fe(II) binding site [ion binding]; other site 262316001663 putative dimer interface [polypeptide binding]; other site 262316001664 putative tetramer interface [polypeptide binding]; other site 262316001665 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 262316001666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001667 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316001668 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 262316001669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001670 NAD(P) binding site [chemical binding]; other site 262316001671 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 262316001672 active site 262316001673 Putative cyclase; Region: Cyclase; cl00814 262316001674 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316001675 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316001676 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 262316001677 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 262316001678 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 262316001679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001680 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316001681 NAD(P) binding site [chemical binding]; other site 262316001682 active site 262316001683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001684 Cytochrome P450; Region: p450; cl12078 262316001685 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316001686 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262316001687 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262316001688 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279 262316001689 active site 262316001690 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262316001691 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262316001692 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279 262316001693 active site 262316001694 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316001695 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316001696 classical (c) SDRs; Region: SDR_c; cd05233 262316001697 NAD(P) binding site [chemical binding]; other site 262316001698 active site 262316001699 hypothetical protein; Provisional; Region: PRK06194 262316001700 classical (c) SDRs; Region: SDR_c; cd05233 262316001701 NAD(P) binding site [chemical binding]; other site 262316001702 active site 262316001703 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316001704 classical (c) SDRs; Region: SDR_c; cd05233 262316001705 NAD(P) binding site [chemical binding]; other site 262316001706 active site 262316001707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001709 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001710 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001711 active site 262316001712 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001713 active site 262316001714 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001715 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001716 active site 262316001717 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 262316001718 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316001719 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 262316001720 active site 262316001721 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316001722 [2Fe-2S] cluster binding site [ion binding]; other site 262316001723 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 262316001724 alpha subunit interface [polypeptide binding]; other site 262316001725 active site 262316001726 substrate binding site [chemical binding]; other site 262316001727 Fe binding site [ion binding]; other site 262316001728 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316001729 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316001730 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001731 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001732 active site 262316001733 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 262316001734 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316001735 dimer interface [polypeptide binding]; other site 262316001736 active site 262316001737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001738 Cytochrome P450; Region: p450; cl12078 262316001739 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 262316001740 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 262316001741 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 262316001742 Cytochrome P450; Region: p450; cl12078 262316001743 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 262316001744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001745 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316001746 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 262316001747 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316001748 lipid-transfer protein; Provisional; Region: PRK07855 262316001749 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316001750 active site 262316001751 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316001752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001753 NAD(P) binding site [chemical binding]; other site 262316001754 active site 262316001755 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316001756 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 262316001757 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316001758 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 262316001759 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 262316001760 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316001761 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 262316001762 iron-sulfur cluster [ion binding]; other site 262316001763 [2Fe-2S] cluster binding site [ion binding]; other site 262316001764 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316001765 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316001766 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 262316001767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001768 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316001769 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 262316001770 FMN binding site [chemical binding]; other site 262316001771 dimer interface [polypeptide binding]; other site 262316001772 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001773 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316001774 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001775 active site 262316001776 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001777 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001778 active site 262316001779 Predicted esterase [General function prediction only]; Region: COG0627 262316001780 Cytochrome P450; Region: p450; cl12078 262316001781 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 262316001782 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316001783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001784 NAD(P) binding site [chemical binding]; other site 262316001785 active site 262316001786 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316001787 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 262316001788 NAD binding site [chemical binding]; other site 262316001789 catalytic residues [active] 262316001790 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316001791 Domain of unknown function DUF140; Region: DUF140; cl00510 262316001792 Domain of unknown function DUF140; Region: DUF140; cl00510 262316001793 mce related protein; Region: MCE; pfam02470 262316001794 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316001795 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001796 mce related protein; Region: MCE; pfam02470 262316001797 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001798 mce related protein; Region: MCE; pfam02470 262316001799 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001800 mce related protein; Region: MCE; pfam02470 262316001801 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001802 mce related protein; Region: MCE; pfam02470 262316001803 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001804 mce related protein; Region: MCE; pfam02470 262316001805 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001807 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits...; Region: NorE_like; cd02862 262316001808 Subunit I/III interface [polypeptide binding]; other site 262316001809 Cytochrome P450; Region: p450; cl12078 262316001810 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001812 enoyl-CoA hydratase; Provisional; Region: PRK06688 262316001813 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316001814 substrate binding site [chemical binding]; other site 262316001815 oxyanion hole (OAH) forming residues; other site 262316001816 trimer interface [polypeptide binding]; other site 262316001817 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 262316001818 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316001819 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 262316001820 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316001821 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 262316001822 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 262316001823 dimer interface [polypeptide binding]; other site 262316001824 PYR/PP interface [polypeptide binding]; other site 262316001825 TPP binding site [chemical binding]; other site 262316001826 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316001827 TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of pyruvate to acetaldehyde and CO2. It is able to utilize...; Region: TPP_PDC_IPDC; cd02005 262316001828 TPP-binding site [chemical binding]; other site 262316001829 dimer interface [polypeptide binding]; other site 262316001830 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 262316001831 putative hydrophobic ligand binding site [chemical binding]; other site 262316001832 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316001833 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 262316001834 putative hydrophobic ligand binding site [chemical binding]; other site 262316001835 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 262316001836 putative hydrophobic ligand binding site [chemical binding]; other site 262316001837 hypothetical protein; Provisional; Region: PRK08912 262316001838 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316001839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316001840 homodimer interface [polypeptide binding]; other site 262316001841 catalytic residue [active] 262316001842 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 262316001843 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316001844 dimer interface [polypeptide binding]; other site 262316001845 active site 262316001846 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 262316001847 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316001848 substrate binding site [chemical binding]; other site 262316001849 oxyanion hole (OAH) forming residues; other site 262316001850 trimer interface [polypeptide binding]; other site 262316001851 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262316001852 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 262316001853 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 262316001854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316001855 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316001856 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 262316001857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001858 hypothetical protein; Provisional; Region: PRK07588 262316001859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001862 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 262316001863 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316001864 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 262316001865 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 262316001866 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316001867 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 262316001868 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316001869 active site 262316001870 DNA repair helicase rad25; Region: rad25; TIGR00603 262316001871 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 262316001872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316001873 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316001874 nucleotide binding region [chemical binding]; other site 262316001875 ATP-binding site [chemical binding]; other site 262316001876 Predicted transcriptional regulator [Transcription]; Region: COG2378 262316001877 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 262316001878 trimer interface [polypeptide binding]; other site 262316001879 dimer interface [polypeptide binding]; other site 262316001880 putative active site [active] 262316001881 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 262316001882 MPT binding site; other site 262316001883 trimer interface [polypeptide binding]; other site 262316001884 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 262316001885 MoaE homodimer interface [polypeptide binding]; other site 262316001886 MoaD interaction [polypeptide binding]; other site 262316001887 active site residues [active] 262316001888 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 262316001889 Ubiquitin-like proteins; Region: UBQ; cl00155 262316001890 charged pocket; other site 262316001891 hydrophobic patch; other site 262316001892 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 262316001893 hypothetical protein; Provisional; Region: PRK11770 262316001894 Domain of unknown function (DUF307); Region: DUF307; pfam03733 262316001895 Domain of unknown function (DUF307); Region: DUF307; pfam03733 262316001896 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 262316001897 DNA-binding site [nucleotide binding]; DNA binding site 262316001898 RNA-binding motif; other site 262316001899 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001900 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001901 active site 262316001902 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 262316001903 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 262316001904 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 262316001905 putative dimer interface [polypeptide binding]; other site 262316001906 N-terminal domain interface [polypeptide binding]; other site 262316001907 putative substrate binding pocket (H-site) [chemical binding]; other site 262316001908 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 262316001909 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 262316001910 H+ Antiporter protein; Region: 2A0121; TIGR00900 262316001911 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 262316001912 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316001913 hydrophobic ligand binding site; other site 262316001914 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 262316001915 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316001916 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 262316001917 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 262316001918 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 262316001919 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 262316001920 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316001921 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 262316001922 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316001923 catalytic residue [active] 262316001924 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 262316001925 Ferredoxin [Energy production and conversion]; Region: COG1146 262316001926 4Fe-4S binding domain; Region: Fer4; cl02805 262316001927 ferredoxin-NADP+ reductase; Region: PLN02852 262316001928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001929 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 262316001930 putative dimer interface [polypeptide binding]; other site 262316001931 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 262316001932 dimer interface [polypeptide binding]; other site 262316001933 Citrate synthase; Region: Citrate_synt; pfam00285 262316001934 active site 262316001935 citrylCoA binding site [chemical binding]; other site 262316001936 oxalacetate/citrate binding site [chemical binding]; other site 262316001937 coenzyme A binding site [chemical binding]; other site 262316001938 catalytic triad [active] 262316001939 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 262316001940 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316001941 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 262316001942 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 262316001943 dimer interface [polypeptide binding]; other site 262316001944 Citrate synthase; Region: Citrate_synt; pfam00285 262316001945 active site 262316001946 citrylCoA binding site [chemical binding]; other site 262316001947 NADH binding [chemical binding]; other site 262316001948 cationic pore residues; other site 262316001949 oxalacetate/citrate binding site [chemical binding]; other site 262316001950 coenzyme A binding site [chemical binding]; other site 262316001951 catalytic triad [active] 262316001952 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 262316001953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001954 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 262316001955 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316001956 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316001957 sensory histidine kinase CreC; Provisional; Region: PRK11100 262316001958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 262316001959 dimer interface [polypeptide binding]; other site 262316001960 phosphorylation site [posttranslational modification] 262316001961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316001962 Mg2+ binding site [ion binding]; other site 262316001963 G-X-G motif; other site 262316001964 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316001965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316001966 active site 262316001967 phosphorylation site [posttranslational modification] 262316001968 intermolecular recognition site; other site 262316001969 dimerization interface [polypeptide binding]; other site 262316001970 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 262316001971 DNA binding site [nucleotide binding] 262316001972 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a...; Region: GT1_AviGT4_like; cd03802 262316001973 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 262316001974 putative ADP-binding pocket [chemical binding]; other site 262316001975 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 262316001976 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 262316001977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001978 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 262316001979 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316001980 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316001981 enoyl-CoA hydratase; Provisional; Region: PRK07854 262316001982 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316001983 substrate binding site [chemical binding]; other site 262316001984 oxyanion hole (OAH) forming residues; other site 262316001985 trimer interface [polypeptide binding]; other site 262316001986 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316001987 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 262316001988 Beta-lactamase; Region: Beta-lactamase; cl01009 262316001989 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 262316001990 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 262316001991 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262316001992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 262316001993 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316001994 hydrophobic ligand binding site; other site 262316001995 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316001996 MULE transposase domain; Region: MULE; pfam10551 262316001997 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262316001998 Integrase core domain; Region: rve; cl01316 262316001999 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316002000 Walker A motif; other site 262316002001 ATP binding site [chemical binding]; other site 262316002002 Walker B motif; other site 262316002003 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 262316002004 putative active site [active] 262316002005 putative metal binding site [ion binding]; other site 262316002006 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 262316002007 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316002008 DNA binding site [nucleotide binding] 262316002009 Int/Topo IB signature motif; other site 262316002010 active site 262316002011 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 262316002012 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316002013 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 262316002014 putative active site pocket [active] 262316002015 dimerization interface [polypeptide binding]; other site 262316002016 putative catalytic residue [active] 262316002017 Protein of unknown function (DUF867); Region: DUF867; cl01713 262316002018 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 262316002019 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316002020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316002021 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316002022 classical (c) SDRs; Region: SDR_c; cd05233 262316002023 NAD(P) binding site [chemical binding]; other site 262316002024 active site 262316002025 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316002026 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 262316002027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316002028 dimer interface [polypeptide binding]; other site 262316002029 conserved gate region; other site 262316002030 putative PBP binding loops; other site 262316002031 ABC-ATPase subunit interface; other site 262316002032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316002033 dimer interface [polypeptide binding]; other site 262316002034 conserved gate region; other site 262316002035 putative PBP binding loops; other site 262316002036 ABC-ATPase subunit interface; other site 262316002037 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 262316002038 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 262316002039 putative DNA binding site [nucleotide binding]; other site 262316002040 putative homodimer interface [polypeptide binding]; other site 262316002041 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 262316002042 putative substrate binding site [chemical binding]; other site 262316002043 putative ATP binding site [chemical binding]; other site 262316002044 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 262316002045 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 262316002046 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 262316002047 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 262316002048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 262316002049 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 262316002050 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 262316002051 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 262316002052 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 262316002053 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: MtLigD_Pol_like; cd04863 262316002054 nucleotide binding site [chemical binding]; other site 262316002055 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 262316002056 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 262316002057 active site 262316002058 DNA binding site [nucleotide binding] 262316002059 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 262316002060 DNA binding site [nucleotide binding] 262316002061 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 262316002062 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316002063 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316002064 enoyl-CoA hydratase; Provisional; Region: PRK08258 262316002065 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316002066 substrate binding site [chemical binding]; other site 262316002067 oxyanion hole (OAH) forming residues; other site 262316002068 trimer interface [polypeptide binding]; other site 262316002069 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316002070 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316002071 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316002072 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316002073 anti sigma factor interaction site; other site 262316002074 regulatory phosphorylation site [posttranslational modification]; other site 262316002075 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 262316002076 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 262316002077 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 262316002078 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 262316002079 putative DNA binding site [nucleotide binding]; other site 262316002080 catalytic residue [active] 262316002081 putative H2TH interface [polypeptide binding]; other site 262316002082 putative catalytic residues [active] 262316002083 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 262316002084 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262316002085 short chain dehydrogenase; Provisional; Region: PRK08251 262316002086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316002087 NAD(P) binding site [chemical binding]; other site 262316002088 active site 262316002089 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 262316002090 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 262316002091 active site 262316002092 dimer interface [polypeptide binding]; other site 262316002093 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 262316002094 dimer interface [polypeptide binding]; other site 262316002095 active site 262316002096 Chorismate mutase type II; Region: CM_2; cl00693 262316002097 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 262316002098 UvrD/REP helicase; Region: UvrD-helicase; cl14126 262316002099 Peptidase family M23; Region: Peptidase_M23; pfam01551 262316002100 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 262316002101 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316002102 CoA-ligase; Region: Ligase_CoA; pfam00549 262316002103 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 262316002104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316002105 CoA-ligase; Region: Ligase_CoA; pfam00549 262316002106 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 262316002107 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316002108 active site 262316002109 Omptin family; Region: Omptin; cl01886 262316002110 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 262316002111 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316002112 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 262316002113 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 262316002114 active site 262316002115 cosubstrate binding site; other site 262316002116 substrate binding site [chemical binding]; other site 262316002117 catalytic site [active] 262316002118 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 262316002119 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 262316002120 purine monophosphate binding site [chemical binding]; other site 262316002121 dimer interface [polypeptide binding]; other site 262316002122 putative catalytic residues [active] 262316002123 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 262316002124 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 262316002125 LGFP repeat; Region: LGFP; pfam08310 262316002126 LGFP repeat; Region: LGFP; pfam08310 262316002127 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 262316002128 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316002129 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 262316002130 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 262316002131 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 262316002132 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262316002133 active site 262316002134 catalytic tetrad [active] 262316002135 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 262316002136 enoyl-CoA hydratase; Provisional; Region: PRK07827 262316002137 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316002138 substrate binding site [chemical binding]; other site 262316002139 oxyanion hole (OAH) forming residues; other site 262316002140 trimer interface [polypeptide binding]; other site 262316002141 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316002142 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 262316002143 active site 262316002144 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 262316002145 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316002146 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316002147 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 262316002148 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 262316002149 carboxyltransferase (CT) interaction site; other site 262316002150 biotinylation site [posttranslational modification]; other site 262316002151 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 262316002152 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316002153 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316002154 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316002155 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316002156 active site 262316002157 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 262316002158 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316002159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316002160 active site 262316002161 phosphorylation site [posttranslational modification] 262316002162 intermolecular recognition site; other site 262316002163 dimerization interface [polypeptide binding]; other site 262316002164 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 262316002165 DNA binding site [nucleotide binding] 262316002166 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 262316002167 dimerization interface [polypeptide binding]; other site 262316002168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 262316002169 dimer interface [polypeptide binding]; other site 262316002170 phosphorylation site [posttranslational modification] 262316002171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316002172 ATP binding site [chemical binding]; other site 262316002173 Mg2+ binding site [ion binding]; other site 262316002174 G-X-G motif; other site 262316002175 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 262316002176 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 262316002177 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 262316002178 MPT binding site; other site 262316002179 trimer interface [polypeptide binding]; other site 262316002180 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 262316002181 SAF domain; Region: SAF; cl00555 262316002182 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 262316002183 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 262316002184 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316002185 active site 262316002186 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 262316002187 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 262316002188 dimer interface [polypeptide binding]; other site 262316002189 putative functional site; other site 262316002190 putative MPT binding site; other site 262316002191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316002192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316002193 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316002194 CoenzymeA binding site [chemical binding]; other site 262316002195 subunit interaction site [polypeptide binding]; other site 262316002196 PHB binding site; other site 262316002197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316002198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316002199 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316002200 [2Fe-2S] cluster binding site [ion binding]; other site 262316002201 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 262316002202 putative alpha subunit interface [polypeptide binding]; other site 262316002203 putative active site [active] 262316002204 putative substrate binding site [chemical binding]; other site 262316002205 Fe binding site [ion binding]; other site 262316002206 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 262316002207 M28, and M42; Region: Zinc_peptidase_like; cl14876 262316002208 metal binding site [ion binding]; metal-binding site 262316002209 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 262316002210 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 262316002211 active site 262316002212 dimer interface [polypeptide binding]; other site 262316002213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 262316002214 active site 262316002215 motif I; other site 262316002216 motif II; other site 262316002217 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 262316002218 ligand binding site [chemical binding]; other site 262316002219 flexible hinge region; other site 262316002220 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 262316002221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316002222 Coenzyme A binding pocket [chemical binding]; other site 262316002223 Amidinotransferase; Region: Amidinotransf; cl12043 262316002224 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 262316002225 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 262316002226 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 262316002227 Predicted methyltransferases [General function prediction only]; Region: COG0313 262316002228 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 262316002229 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 262316002230 chorismate binding enzyme; Region: Chorismate_bind; cl10555 262316002231 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 262316002232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 262316002233 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316002234 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 262316002235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316002236 GAF domain; Region: GAF; cl00853 262316002237 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262316002238 metal binding site [ion binding]; metal-binding site 262316002239 active site 262316002240 I-site; other site 262316002241 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262316002242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316002243 Chain length determinant protein; Region: Wzz; cl01623 262316002244 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 262316002245 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316002246 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316002247 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 262316002248 catalytic tetrad [active] 262316002249 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 262316002250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316002251 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 262316002252 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 262316002253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316002254 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 262316002255 Glycosyltransferase family 28 N-terminal domain; Region: Glyco_transf_28; cl07328 262316002256 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 262316002257 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 262316002258 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316002259 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316002260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316002261 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316002262 MatE; Region: MatE; cl10513 262316002263 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 262316002264 Bacterial sugar transferase; Region: Bac_transf; cl00939 262316002265 Cupin domain; Region: Cupin_2; cl09118 262316002266 PPE family; Region: PPE; pfam00823 262316002267 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316002268 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316002269 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316002270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316002271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316002272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316002273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316002274 outer membrane N-deacetylase; Provisional; Region: hmsF; PRK14581 262316002275 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 262316002276 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 262316002277 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 262316002278 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 262316002279 active site 262316002280 HIGH motif; other site 262316002281 KMSKS motif; other site 262316002282 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 262316002283 tRNA binding surface [nucleotide binding]; other site 262316002284 anticodon binding site; other site 262316002285 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 262316002286 active site 262316002287 Domain of unknown function (DUF348); Region: DUF348; pfam03990 262316002288 G5 domain; Region: G5; pfam07501 262316002289 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 262316002290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316002291 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 262316002292 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 262316002293 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316002294 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316002295 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316002296 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 262316002297 putative active site [active] 262316002298 catalytic residue [active] 262316002299 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 262316002300 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 262316002301 5S rRNA interface [nucleotide binding]; other site 262316002302 CTC domain interface [polypeptide binding]; other site 262316002303 L16 interface [polypeptide binding]; other site 262316002304 short chain dehydrogenase; Provisional; Region: PRK06197 262316002305 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 262316002306 putative NAD(P) binding site [chemical binding]; other site 262316002307 active site 262316002308 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 262316002309 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 262316002310 catalytic residues [active] 262316002311 ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251 262316002312 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 262316002313 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 262316002314 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 262316002315 Substrate binding site [chemical binding]; other site 262316002316 Mg++ binding site [ion binding]; other site 262316002317 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 262316002318 active site 262316002319 substrate binding site [chemical binding]; other site 262316002320 CoA binding site [chemical binding]; other site 262316002321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316002322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316002323 diaminopimelate decarboxylase; Region: lysA; TIGR01048 262316002324 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 262316002325 active site 262316002326 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 262316002327 substrate binding site [chemical binding]; other site 262316002328 catalytic residues [active] 262316002329 dimer interface [polypeptide binding]; other site 262316002330 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 262316002331 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 262316002332 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316002333 ATP binding site [chemical binding]; other site 262316002334 putative Mg++ binding site [ion binding]; other site 262316002335 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316002336 nucleotide binding region [chemical binding]; other site 262316002337 ATP-binding site [chemical binding]; other site 262316002338 TRCF domain; Region: TRCF; cl04088 262316002339 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 262316002340 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 262316002341 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 262316002342 N-acetyl-D-glucosamine binding site [chemical binding]; other site 262316002343 enolase; Provisional; Region: eno; PRK00077 262316002344 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 262316002345 dimer interface [polypeptide binding]; other site 262316002346 metal binding site [ion binding]; metal-binding site 262316002347 substrate binding pocket [chemical binding]; other site 262316002348 Septum formation initiator; Region: DivIC; cl11433 262316002349 Protein of unknown function (DUF501); Region: DUF501; cl00652 262316002350 exopolyphosphatase; Region: exo_poly_only; TIGR03706 262316002351 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 262316002352 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 262316002353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316002354 active site 262316002355 phosphorylation site [posttranslational modification] 262316002356 intermolecular recognition site; other site 262316002357 dimerization interface [polypeptide binding]; other site 262316002358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 262316002359 DNA binding site [nucleotide binding] 262316002360 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 262316002361 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 262316002362 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 262316002363 Ligand Binding Site [chemical binding]; other site 262316002364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 262316002365 dimer interface [polypeptide binding]; other site 262316002366 phosphorylation site [posttranslational modification] 262316002367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316002368 ATP binding site [chemical binding]; other site 262316002369 Mg2+ binding site [ion binding]; other site 262316002370 G-X-G motif; other site 262316002371 K+-transporting ATPase, c chain; Region: KdpC; cl00944 262316002372 K+-transporting ATPase, c chain; Region: KdpC; cl00944 262316002373 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 262316002374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 262316002375 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262316002376 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 262316002377 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 262316002378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 262316002379 dimer interface [polypeptide binding]; other site 262316002380 phosphorylation site [posttranslational modification] 262316002381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316002382 ATP binding site [chemical binding]; other site 262316002383 Mg2+ binding site [ion binding]; other site 262316002384 G-X-G motif; other site 262316002385 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316002386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316002387 active site 262316002388 phosphorylation site [posttranslational modification] 262316002389 intermolecular recognition site; other site 262316002390 dimerization interface [polypeptide binding]; other site 262316002391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 262316002392 DNA binding site [nucleotide binding] 262316002393 PE family; Region: PE; pfam00934 262316002394 PPE family; Region: PPE; pfam00823 262316002395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316002396 S-adenosylmethionine binding site [chemical binding]; other site 262316002397 Domain of unknown function (DUF427); Region: DUF427; cl00998 262316002398 Domain of unknown function (DUF427); Region: DUF427; cl00998 262316002399 Uncharacterized conserved protein [Function unknown]; Region: COG3391 262316002400 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 262316002401 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316002402 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 262316002403 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 262316002404 putative hydrophobic ligand binding site [chemical binding]; other site 262316002405 protein interface [polypeptide binding]; other site 262316002406 gate; other site 262316002407 TIGR03442 family protein; Region: TIGR03442 262316002408 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 262316002409 putative active site [active] 262316002410 putative dimer interface [polypeptide binding]; other site 262316002411 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 262316002412 nucleophile elbow; other site 262316002413 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 262316002414 active site 262316002415 nucleophile elbow; other site 262316002416 Cysteine dioxygenase type I; Region: CDO_I; cl02350 262316002417 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 262316002418 active site residue [active] 262316002419 Predicted membrane protein [Function unknown]; Region: COG4425 262316002420 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 262316002421 enoyl-CoA hydratase; Provisional; Region: PRK05862 262316002422 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316002423 substrate binding site [chemical binding]; other site 262316002424 oxyanion hole (OAH) forming residues; other site 262316002425 trimer interface [polypeptide binding]; other site 262316002426 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 262316002427 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316002428 substrate binding site [chemical binding]; other site 262316002429 oxyanion hole (OAH) forming residues; other site 262316002430 trimer interface [polypeptide binding]; other site 262316002431 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 262316002432 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316002433 active site 262316002434 Thiolase, N-terminal domain; Region: Thiolase_N; pfam00108 262316002435 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316002436 dimer interface [polypeptide binding]; other site 262316002437 FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it turn are loaded onto the acyl...; Region: FeeA_FeeB_like; cd01836 262316002438 active site 262316002439 catalytic triad [active] 262316002440 oxyanion hole [active] 262316002441 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 262316002442 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316002443 substrate binding pocket [chemical binding]; other site 262316002444 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 262316002445 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 262316002446 dimer interface [polypeptide binding]; other site 262316002447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316002448 catalytic residue [active] 262316002449 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as...; Region: CBS_pair_PALP_assoc2; cd04609 262316002450 RDD family; Region: RDD; cl00746 262316002451 cystathionine gamma-synthase; Provisional; Region: PRK07811 262316002452 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 262316002453 homodimer interface [polypeptide binding]; other site 262316002454 substrate-cofactor binding pocket; other site 262316002455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316002456 catalytic residue [active] 262316002457 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 262316002458 domain; Region: GreA_GreB_N; pfam03449 262316002459 C-term; Region: GreA_GreB; pfam01272 262316002460 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 262316002461 Domain of unknown function DUF28; Region: DUF28; cl00361 262316002462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316002463 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 262316002464 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 262316002465 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316002466 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316002467 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 262316002468 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 262316002469 active site 262316002470 putative DNA-binding cleft [nucleotide binding]; other site 262316002471 dimer interface [polypeptide binding]; other site 262316002472 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 262316002473 RuvA N terminal domain; Region: RuvA_N; pfam01330 262316002474 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 262316002475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316002476 Walker A motif; other site 262316002477 ATP binding site [chemical binding]; other site 262316002478 Walker B motif; other site 262316002479 arginine finger; other site 262316002480 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 262316002481 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 262316002482 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316002483 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316002484 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316002485 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 262316002486 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 262316002487 putative NAD(P) binding site [chemical binding]; other site 262316002488 active site 262316002489 putative substrate binding site [chemical binding]; other site 262316002490 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 262316002491 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 262316002492 inhibitor-cofactor binding pocket; inhibition site 262316002493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316002494 catalytic residue [active] 262316002495 Preprotein translocase subunit; Region: YajC; cl00806 262316002496 protein-export membrane protein SecD; Region: secD; TIGR01129 262316002497 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 262316002498 Protein export membrane protein; Region: SecD_SecF; cl14618 262316002499 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 262316002500 Protein export membrane protein; Region: SecD_SecF; cl14618 262316002501 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 262316002502 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 262316002503 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 262316002504 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 262316002505 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 262316002506 synthetase active site [active] 262316002507 NTP binding site [chemical binding]; other site 262316002508 metal binding site [ion binding]; metal-binding site 262316002509 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 262316002510 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 262316002511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 262316002512 Integrase core domain; Region: rve; cl01316 262316002513 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316002514 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316002515 active site 262316002516 ATP binding site [chemical binding]; other site 262316002517 substrate binding site [chemical binding]; other site 262316002518 activation loop (A-loop); other site 262316002519 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 262316002520 active site 262316002521 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 262316002522 active site 262316002523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316002524 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 262316002525 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 262316002526 dimer interface [polypeptide binding]; other site 262316002527 motif 1; other site 262316002528 active site 262316002529 motif 2; other site 262316002530 motif 3; other site 262316002531 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 262316002532 anticodon binding site; other site 262316002533 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316002534 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316002535 active site 262316002536 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 262316002537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 262316002538 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 262316002539 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 262316002540 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 262316002541 active site 262316002542 metal binding site [ion binding]; metal-binding site 262316002543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316002544 non-specific DNA binding site [nucleotide binding]; other site 262316002545 salt bridge; other site 262316002546 sequence-specific DNA binding site [nucleotide binding]; other site 262316002547 Cupin domain; Region: Cupin_2; cl09118 262316002548 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 262316002549 intersubunit interface [polypeptide binding]; other site 262316002550 active site 262316002551 Zn2+ binding site [ion binding]; other site 262316002552 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 262316002553 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 262316002554 inhibitor site; inhibition site 262316002555 active site 262316002556 dimer interface [polypeptide binding]; other site 262316002557 catalytic residue [active] 262316002558 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 262316002559 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 262316002560 putative hydrophobic ligand binding site [chemical binding]; other site 262316002561 protein interface [polypeptide binding]; other site 262316002562 gate; other site 262316002563 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 262316002564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316002565 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 262316002566 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 262316002567 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 262316002568 dimer interface [polypeptide binding]; other site 262316002569 anticodon binding site; other site 262316002570 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 262316002571 homodimer interface [polypeptide binding]; other site 262316002572 motif 1; other site 262316002573 active site 262316002574 motif 2; other site 262316002575 GAD domain; Region: GAD; pfam02938 262316002576 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262316002577 active site 262316002578 motif 3; other site 262316002579 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316002580 Predicted membrane protein [Function unknown]; Region: COG4129 262316002581 Protein of unknown function (DUF419); Region: DUF419; cl15265 262316002582 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 262316002583 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 262316002584 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 262316002585 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl09206 262316002586 Uncharacterized conserved protein [Function unknown]; Region: COG2308 262316002587 Domain of unknown function (DUF404); Region: DUF404; pfam04169 262316002588 Domain of unknown function (DUF407); Region: DUF407; pfam04174 262316002589 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 262316002590 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 262316002591 recombination factor protein RarA; Reviewed; Region: PRK13342 262316002592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316002593 Walker A motif; other site 262316002594 ATP binding site [chemical binding]; other site 262316002595 Walker B motif; other site 262316002596 arginine finger; other site 262316002597 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 262316002598 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 262316002599 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 262316002600 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 262316002601 motif 1; other site 262316002602 active site 262316002603 motif 2; other site 262316002604 motif 3; other site 262316002605 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 262316002606 DHHA1 domain; Region: DHHA1; pfam02272 262316002607 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 262316002608 YceG-like family; Region: YceG; pfam02618 262316002609 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 262316002610 dimerization interface [polypeptide binding]; other site 262316002611 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 262316002612 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 262316002613 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 262316002614 NAD(P) binding site [chemical binding]; other site 262316002615 shikimate binding site; other site 262316002616 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 262316002617 active site 262316002618 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 262316002619 dimer interface [polypeptide binding]; other site 262316002620 non-prolyl cis peptide bond; other site 262316002621 insertion regions; other site 262316002622 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 262316002623 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 262316002624 active site 262316002625 non-prolyl cis peptide bond; other site 262316002626 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316002627 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316002628 active site 262316002629 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 262316002630 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 262316002631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 262316002632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 262316002633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316002634 dimer interface [polypeptide binding]; other site 262316002635 conserved gate region; other site 262316002636 putative PBP binding loops; other site 262316002637 ABC-ATPase subunit interface; other site 262316002638 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 262316002639 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 262316002640 Walker A/P-loop; other site 262316002641 ATP binding site [chemical binding]; other site 262316002642 Q-loop/lid; other site 262316002643 ABC transporter signature motif; other site 262316002644 Walker B; other site 262316002645 D-loop; other site 262316002646 H-loop/switch region; other site 262316002647 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 262316002648 Walker A/P-loop; other site 262316002649 ATP binding site [chemical binding]; other site 262316002650 Q-loop/lid; other site 262316002651 ABC transporter signature motif; other site 262316002652 Walker B; other site 262316002653 D-loop; other site 262316002654 H-loop/switch region; other site 262316002655 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 262316002656 Tetramer interface [polypeptide binding]; other site 262316002657 Active site [active] 262316002658 FMN-binding site [chemical binding]; other site 262316002659 shikimate kinase; Reviewed; Region: aroK; PRK00131 262316002660 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 262316002661 ADP binding site [chemical binding]; other site 262316002662 magnesium binding site [ion binding]; other site 262316002663 putative shikimate binding site; other site 262316002664 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 262316002665 active site 262316002666 dimer interface [polypeptide binding]; other site 262316002667 metal binding site [ion binding]; metal-binding site 262316002668 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 262316002669 trimer interface [polypeptide binding]; other site 262316002670 active site 262316002671 dimer interface [polypeptide binding]; other site 262316002672 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262316002673 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262316002674 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 262316002675 active site 262316002676 elongation factor P; Validated; Region: PRK00529 262316002677 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 262316002678 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 262316002679 RNA binding site [nucleotide binding]; other site 262316002680 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 262316002681 RNA binding site [nucleotide binding]; other site 262316002682 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 262316002683 putative RNA binding site [nucleotide binding]; other site 262316002684 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 262316002685 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316002686 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316002687 catalytic residue [active] 262316002688 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 262316002689 sensor kinase CusS; Provisional; Region: PRK09835 262316002690 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 262316002691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 262316002692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316002693 ATP binding site [chemical binding]; other site 262316002694 Mg2+ binding site [ion binding]; other site 262316002695 G-X-G motif; other site 262316002696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316002697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316002698 active site 262316002699 phosphorylation site [posttranslational modification] 262316002700 intermolecular recognition site; other site 262316002701 dimerization interface [polypeptide binding]; other site 262316002702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 262316002703 DNA binding site [nucleotide binding] 262316002704 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 262316002705 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 262316002706 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 262316002707 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 262316002708 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 262316002709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316002710 DNA-binding site [nucleotide binding]; DNA binding site 262316002711 UTRA domain; Region: UTRA; cl01230 262316002712 ferredoxin; Provisional; Region: PRK06991 262316002713 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 262316002714 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 262316002715 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 262316002716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316002717 dimer interface [polypeptide binding]; other site 262316002718 conserved gate region; other site 262316002719 putative PBP binding loops; other site 262316002720 ABC-ATPase subunit interface; other site 262316002721 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 262316002722 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 262316002723 Walker A/P-loop; other site 262316002724 ATP binding site [chemical binding]; other site 262316002725 Q-loop/lid; other site 262316002726 ABC transporter signature motif; other site 262316002727 Walker B; other site 262316002728 D-loop; other site 262316002729 H-loop/switch region; other site 262316002730 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 262316002731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316002732 domain; Region: Succ_DH_flav_C; pfam02910 262316002733 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 262316002734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316002735 Beta-lactamase; Region: Beta-lactamase; cl01009 262316002736 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 262316002737 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 262316002738 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 262316002739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316002740 dihydroorotase; Validated; Region: pyrC; PRK09357 262316002741 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316002742 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 262316002743 active site 262316002744 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 262316002745 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 262316002746 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 262316002747 catalytic site [active] 262316002748 subunit interface [polypeptide binding]; other site 262316002749 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 262316002750 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316002751 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316002752 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 262316002753 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316002754 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316002755 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 262316002756 IMP binding site; other site 262316002757 dimer interface [polypeptide binding]; other site 262316002758 interdomain contacts; other site 262316002759 partial ornithine binding site; other site 262316002760 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 262316002761 active site 262316002762 dimer interface [polypeptide binding]; other site 262316002763 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 262316002764 DNA binding residues [nucleotide binding] 262316002765 TOBE domain; Region: TOBE_2; cl01440 262316002766 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 262316002767 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 262316002768 catalytic site [active] 262316002769 G-X2-G-X-G-K; other site 262316002770 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 262316002771 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 262316002772 Flavoprotein; Region: Flavoprotein; cl08021 262316002773 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 262316002774 S-adenosylmethionine synthetase; Validated; Region: PRK05250 262316002775 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 262316002776 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 262316002777 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 262316002778 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316002779 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316002780 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316002781 substrate binding pocket [chemical binding]; other site 262316002782 YhhN-like protein; Region: YhhN; cl01505 262316002783 primosome assembly protein PriA; Provisional; Region: PRK14873 262316002784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316002785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316002786 S-adenosylmethionine binding site [chemical binding]; other site 262316002787 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 262316002788 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 262316002789 putative active site [active] 262316002790 substrate binding site [chemical binding]; other site 262316002791 putative cosubstrate binding site; other site 262316002792 catalytic site [active] 262316002793 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 262316002794 substrate binding site [chemical binding]; other site 262316002795 16S rRNA methyltransferase B; Provisional; Region: PRK14902 262316002796 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 262316002797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316002798 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 262316002799 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 262316002800 substrate binding site [chemical binding]; other site 262316002801 hexamer interface [polypeptide binding]; other site 262316002802 metal binding site [ion binding]; metal-binding site 262316002803 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 262316002804 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 262316002805 catalytic motif [active] 262316002806 Zn binding site [ion binding]; other site 262316002807 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 262316002808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316002809 putative substrate translocation pore; other site 262316002810 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 262316002811 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 262316002812 Lumazine binding domain; Region: Lum_binding; pfam00677 262316002813 Lumazine binding domain; Region: Lum_binding; pfam00677 262316002814 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 262316002815 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 262316002816 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 262316002817 dimerization interface [polypeptide binding]; other site 262316002818 active site 262316002819 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 262316002820 homopentamer interface [polypeptide binding]; other site 262316002821 active site 262316002822 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 262316002823 PPE family; Region: PPE; pfam00823 262316002824 Cupin superfamily protein; Region: Cupin_4; pfam08007 262316002825 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 262316002826 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 262316002827 GIY-YIG motif/motif A; other site 262316002828 active site 262316002829 catalytic site [active] 262316002830 putative DNA binding site [nucleotide binding]; other site 262316002831 metal binding site [ion binding]; metal-binding site 262316002832 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 262316002833 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316002834 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 262316002835 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 262316002836 phosphate binding site [ion binding]; other site 262316002837 putative substrate binding pocket [chemical binding]; other site 262316002838 dimer interface [polypeptide binding]; other site 262316002839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 262316002840 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 262316002841 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316002842 MULE transposase domain; Region: MULE; pfam10551 262316002843 PPE family; Region: PPE; pfam00823 262316002844 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316002845 PPE family; Region: PPE; pfam00823 262316002846 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316002847 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316002848 PPE family; Region: PPE; pfam00823 262316002849 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316002850 Condensation domain; Region: Condensation; cl09290 262316002851 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 262316002852 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316002853 substrate binding pocket [chemical binding]; other site 262316002854 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316002855 acyl-CoA synthetase; Provisional; Region: PRK13382 262316002856 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316002857 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 262316002858 putative acyl-acceptor binding pocket; other site 262316002859 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 262316002860 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 262316002861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316002862 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 262316002863 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 262316002864 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 262316002865 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 262316002866 substrate binding site [chemical binding]; other site 262316002867 hinge regions; other site 262316002868 ADP binding site [chemical binding]; other site 262316002869 catalytic site [active] 262316002870 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 262316002871 substrate binding site [chemical binding]; other site 262316002872 dimer interface [polypeptide binding]; other site 262316002873 catalytic triad [active] 262316002874 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 262316002875 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316002876 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316002877 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 262316002878 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 262316002879 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 262316002880 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 262316002881 active site 262316002882 catalytic tetrad [active] 262316002883 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 262316002884 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 262316002885 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 262316002886 putative active site [active] 262316002887 opcA protein; Region: OpcA; TIGR00534 262316002888 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 262316002889 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 262316002890 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 262316002891 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 262316002892 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 262316002893 putative active site [active] 262316002894 transaldolase; Provisional; Region: PRK03903 262316002895 catalytic residue [active] 262316002896 transketolase; Reviewed; Region: PRK05899 262316002897 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 262316002898 TPP-binding site [chemical binding]; other site 262316002899 dimer interface [polypeptide binding]; other site 262316002900 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 262316002901 PYR/PP interface [polypeptide binding]; other site 262316002902 dimer interface [polypeptide binding]; other site 262316002903 TPP binding site [chemical binding]; other site 262316002904 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262316002905 UbiA prenyltransferase family; Region: UbiA; cl00337 262316002906 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 262316002907 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 262316002908 NADP binding site [chemical binding]; other site 262316002909 dimer interface [polypeptide binding]; other site 262316002910 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 262316002911 ABC-2 type transporter; Region: ABC2_membrane; cl11417 262316002912 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 262316002913 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 262316002914 Walker A/P-loop; other site 262316002915 ATP binding site [chemical binding]; other site 262316002916 Q-loop/lid; other site 262316002917 ABC transporter signature motif; other site 262316002918 Walker B; other site 262316002919 D-loop; other site 262316002920 H-loop/switch region; other site 262316002921 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 262316002922 Predicted transcriptional regulator [Transcription]; Region: COG2345 262316002923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316002924 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 262316002925 FeS assembly protein SufB; Region: sufB; TIGR01980 262316002926 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 262316002927 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 262316002928 FeS assembly ATPase SufC; Region: sufC; TIGR01978 262316002929 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 262316002930 Walker A/P-loop; other site 262316002931 ATP binding site [chemical binding]; other site 262316002932 Q-loop/lid; other site 262316002933 ABC transporter signature motif; other site 262316002934 Walker B; other site 262316002935 D-loop; other site 262316002936 H-loop/switch region; other site 262316002937 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 262316002938 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 262316002939 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316002940 catalytic residue [active] 262316002941 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 262316002942 trimerization site [polypeptide binding]; other site 262316002943 active site 262316002944 Domain of unknown function DUF59; Region: DUF59; cl00941 262316002945 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 262316002946 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 262316002947 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316002948 active site 262316002949 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 262316002950 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262316002951 catalytic residues [active] 262316002952 enoyl-CoA hydratase; Provisional; Region: PRK05864 262316002953 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316002954 substrate binding site [chemical binding]; other site 262316002955 oxyanion hole (OAH) forming residues; other site 262316002956 trimer interface [polypeptide binding]; other site 262316002957 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 262316002958 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316002959 Walker A/P-loop; other site 262316002960 ATP binding site [chemical binding]; other site 262316002961 Q-loop/lid; other site 262316002962 ABC transporter signature motif; other site 262316002963 Walker B; other site 262316002964 D-loop; other site 262316002965 H-loop/switch region; other site 262316002966 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 262316002967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316002968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316002969 aconitate hydratase; Validated; Region: PRK09277 262316002970 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 262316002971 substrate binding site [chemical binding]; other site 262316002972 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 262316002973 ligand binding site [chemical binding]; other site 262316002974 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 262316002975 substrate binding site [chemical binding]; other site 262316002976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 262316002977 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 262316002978 NlpC/P60 family; Region: NLPC_P60; cl11438 262316002979 NlpC/P60 family; Region: NLPC_P60; cl11438 262316002980 MoxR-like ATPases [General function prediction only]; Region: COG0714 262316002981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316002982 Walker A motif; other site 262316002983 ATP binding site [chemical binding]; other site 262316002984 Walker B motif; other site 262316002985 arginine finger; other site 262316002986 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 262316002987 Protein of unknown function DUF58; Region: DUF58; pfam01882 262316002988 hypothetical protein; Provisional; Region: PRK13685 262316002989 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 262316002990 metal ion-dependent adhesion site (MIDAS); other site 262316002991 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 262316002992 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 262316002993 NAD(P) binding site [chemical binding]; other site 262316002994 homotetramer interface [polypeptide binding]; other site 262316002995 homodimer interface [polypeptide binding]; other site 262316002996 active site 262316002997 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 262316002998 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 262316002999 NAD binding site [chemical binding]; other site 262316003000 homotetramer interface [polypeptide binding]; other site 262316003001 homodimer interface [polypeptide binding]; other site 262316003002 substrate binding site [chemical binding]; other site 262316003003 active site 262316003004 ferrochelatase; Reviewed; Region: hemH; PRK00035 262316003005 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 262316003006 C-terminal domain interface [polypeptide binding]; other site 262316003007 active site 262316003008 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 262316003009 active site 262316003010 N-terminal domain interface [polypeptide binding]; other site 262316003011 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 262316003012 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 262316003013 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 262316003014 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316003015 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316003016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316003017 active site 262316003018 phosphorylation site [posttranslational modification] 262316003019 intermolecular recognition site; other site 262316003020 dimerization interface [polypeptide binding]; other site 262316003021 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 262316003022 DNA binding site [nucleotide binding] 262316003023 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 262316003024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 262316003025 dimer interface [polypeptide binding]; other site 262316003026 phosphorylation site [posttranslational modification] 262316003027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316003028 Mg2+ binding site [ion binding]; other site 262316003029 G-X-G motif; other site 262316003030 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 262316003031 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 262316003032 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 262316003033 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 262316003034 heterodimer interface [polypeptide binding]; other site 262316003035 substrate interaction site [chemical binding]; other site 262316003036 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 262316003037 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 262316003038 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily...; Region: MM_CoA_mutase_alpha_like; cd03679 262316003039 active site 262316003040 substrate binding site [chemical binding]; other site 262316003041 coenzyme B12 binding site [chemical binding]; other site 262316003042 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 262316003043 B12 binding site [chemical binding]; other site 262316003044 cobalt ligand [ion binding]; other site 262316003045 membrane ATPase/protein kinase; Provisional; Region: PRK09435 262316003046 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 262316003047 Walker A; other site 262316003048 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 262316003049 Beta-lactamase; Region: Beta-lactamase; cl01009 262316003050 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316003051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 262316003052 GDP-mannose 4,6-dehydratase; Region: PLN02653 262316003053 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 262316003054 NADP-binding site; other site 262316003055 homotetramer interface [polypeptide binding]; other site 262316003056 substrate binding site [chemical binding]; other site 262316003057 homodimer interface [polypeptide binding]; other site 262316003058 active site 262316003059 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 262316003060 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 262316003061 NADP binding site [chemical binding]; other site 262316003062 active site 262316003063 putative substrate binding site [chemical binding]; other site 262316003064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316003065 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 262316003066 metal binding site [ion binding]; metal-binding site 262316003067 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316003068 ABC-2 type transporter; Region: ABC2_membrane; cl11417 262316003069 ABC-2 type transporter; Region: ABC2_membrane; cl11417 262316003070 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316003071 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 262316003072 Walker A/P-loop; other site 262316003073 ATP binding site [chemical binding]; other site 262316003074 Q-loop/lid; other site 262316003075 ABC transporter signature motif; other site 262316003076 Walker B; other site 262316003077 D-loop; other site 262316003078 H-loop/switch region; other site 262316003079 Transport protein; Region: actII; TIGR00833 262316003080 Transport protein; Region: actII; TIGR00833 262316003081 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316003082 Condensation domain; Region: Condensation; cl09290 262316003083 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 262316003084 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316003085 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316003086 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316003087 Condensation domain; Region: Condensation; cl09290 262316003088 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 262316003089 Condensation domain; Region: Condensation; cl09290 262316003090 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316003091 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316003092 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316003093 peptide synthase; Provisional; Region: PRK12467 262316003094 Condensation domain; Region: Condensation; cl09290 262316003095 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316003096 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316003097 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 262316003098 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 262316003099 putative NAD(P) binding site [chemical binding]; other site 262316003100 active site 262316003101 putative substrate binding site [chemical binding]; other site 262316003102 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316003103 Nitronate monooxygenase; Region: NMO; pfam03060 262316003104 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 262316003105 FMN binding site [chemical binding]; other site 262316003106 substrate binding site [chemical binding]; other site 262316003107 putative catalytic residue [active] 262316003108 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 262316003109 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 262316003110 HIGH motif; other site 262316003111 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 262316003112 active site 262316003113 KMSKS motif; other site 262316003114 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 262316003115 tRNA binding surface [nucleotide binding]; other site 262316003116 anticodon binding site; other site 262316003117 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 262316003118 DNA polymerase IV; Provisional; Region: PRK03348 262316003119 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 262316003120 active site 262316003121 DNA binding site [nucleotide binding] 262316003122 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 262316003123 active site/substrate binding site [active] 262316003124 tetramer interface [polypeptide binding]; other site 262316003125 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 262316003126 lipoprotein signal peptidase; Provisional; Region: PRK14787 262316003127 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 262316003128 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 262316003129 active site 262316003130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316003131 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 262316003132 apolar tunnel; other site 262316003133 heme binding site [chemical binding]; other site 262316003134 dimerization interface [polypeptide binding]; other site 262316003135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003136 NAD(P) binding site [chemical binding]; other site 262316003137 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262316003138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003139 NAD(P) binding site [chemical binding]; other site 262316003140 active site 262316003141 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316003142 hydrophobic ligand binding site; other site 262316003143 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 262316003144 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 262316003145 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 262316003146 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 262316003147 generic binding surface II; other site 262316003148 generic binding surface I; other site 262316003149 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316003150 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 262316003151 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 262316003152 DNA binding residues [nucleotide binding] 262316003153 putative dimer interface [polypeptide binding]; other site 262316003154 putative metal binding residues [ion binding]; other site 262316003155 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316003156 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 262316003157 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 262316003158 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 262316003159 putative acyl-acceptor binding pocket; other site 262316003160 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316003161 threonine dehydratase; Validated; Region: PRK08639 262316003162 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 262316003163 tetramer interface [polypeptide binding]; other site 262316003164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316003165 catalytic residue [active] 262316003166 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 262316003167 putative Ile/Val binding site [chemical binding]; other site 262316003168 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 262316003169 active site 262316003170 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316003171 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 262316003172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316003173 DNA-binding site [nucleotide binding]; DNA binding site 262316003174 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316003175 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316003176 catalytic residue [active] 262316003177 Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853 262316003178 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 262316003179 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 262316003180 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 262316003181 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 262316003182 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 262316003183 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 262316003184 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 262316003185 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 262316003186 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316003187 NlpC/P60 family; Region: NLPC_P60; cl11438 262316003188 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 262316003189 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 262316003190 inhibitor-cofactor binding pocket; inhibition site 262316003191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316003192 catalytic residue [active] 262316003193 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 262316003194 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316003195 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316003196 catalytic residue [active] 262316003197 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 262316003198 Mechanosensitive ion channel; Region: MS_channel; pfam00924 262316003199 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 262316003200 dimerization interface [polypeptide binding]; other site 262316003201 cyclase homology domain; Region: CHD; cd07302 262316003202 nucleotidyl binding site; other site 262316003203 metal binding site [ion binding]; metal-binding site 262316003204 dimer interface [polypeptide binding]; other site 262316003205 biotin synthase; Validated; Region: PRK06256 262316003206 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 262316003207 FeS/SAM binding site; other site 262316003208 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 262316003209 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 262316003210 Secretory lipase; Region: LIP; pfam03583 262316003211 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316003212 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316003213 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 262316003214 nudix motif; other site 262316003215 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 262316003216 Quinolinate synthetase A protein; Region: NadA; cl00420 262316003217 L-aspartate oxidase; Provisional; Region: PRK07804 262316003218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003219 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 262316003220 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 262316003221 dimerization interface [polypeptide binding]; other site 262316003222 active site 262316003223 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316003224 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 262316003225 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 262316003226 NAD binding site [chemical binding]; other site 262316003227 dimerization interface [polypeptide binding]; other site 262316003228 product binding site; other site 262316003229 substrate binding site [chemical binding]; other site 262316003230 zinc binding site [ion binding]; other site 262316003231 catalytic residues [active] 262316003232 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 262316003233 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316003234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316003235 homodimer interface [polypeptide binding]; other site 262316003236 catalytic residue [active] 262316003237 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 262316003238 putative active site pocket [active] 262316003239 4-fold oligomerization interface [polypeptide binding]; other site 262316003240 metal binding residues [ion binding]; metal-binding site 262316003241 3-fold/trimer interface [polypeptide binding]; other site 262316003242 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 262316003243 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 262316003244 putative active site [active] 262316003245 oxyanion strand; other site 262316003246 catalytic triad [active] 262316003247 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 262316003248 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 262316003249 catalytic residues [active] 262316003250 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 262316003251 active site 262316003252 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 262316003253 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 262316003254 substrate binding site [chemical binding]; other site 262316003255 glutamase interaction surface [polypeptide binding]; other site 262316003256 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 262316003257 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 262316003258 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 262316003259 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 262316003260 catalytic triad [active] 262316003261 anthranilate synthase component I; Provisional; Region: PRK13571 262316003262 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 262316003263 chorismate binding enzyme; Region: Chorismate_bind; cl10555 262316003264 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl09759 262316003265 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 262316003266 active site 262316003267 ribulose/triose binding site [chemical binding]; other site 262316003268 phosphate binding site [ion binding]; other site 262316003269 substrate (anthranilate) binding pocket [chemical binding]; other site 262316003270 product (indole) binding pocket [chemical binding]; other site 262316003271 tryptophan synthase, beta chain; Region: PLN02618 262316003272 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 262316003273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316003274 catalytic residue [active] 262316003275 tryptophan synthase; Region: PLN02591 262316003276 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 262316003277 substrate binding site [chemical binding]; other site 262316003278 active site 262316003279 catalytic residues [active] 262316003280 heterodimer interface [polypeptide binding]; other site 262316003281 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 262316003282 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 262316003283 pyruvate kinase; Provisional; Region: PRK06247 262316003284 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 262316003285 domain interfaces; other site 262316003286 active site 262316003287 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 262316003288 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 262316003289 active site 262316003290 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 262316003291 catalytic triad [active] 262316003292 dimer interface [polypeptide binding]; other site 262316003293 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 262316003294 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 262316003295 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316003296 Walker A/P-loop; other site 262316003297 ATP binding site [chemical binding]; other site 262316003298 Q-loop/lid; other site 262316003299 ABC transporter signature motif; other site 262316003300 Walker B; other site 262316003301 D-loop; other site 262316003302 H-loop/switch region; other site 262316003303 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 262316003304 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 262316003305 Walker A/P-loop; other site 262316003306 ATP binding site [chemical binding]; other site 262316003307 Q-loop/lid; other site 262316003308 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 262316003309 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 262316003310 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 262316003311 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 262316003312 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 262316003313 cyclase homology domain; Region: CHD; cd07302 262316003314 nucleotidyl binding site; other site 262316003315 metal binding site [ion binding]; metal-binding site 262316003316 dimer interface [polypeptide binding]; other site 262316003317 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 262316003318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316003319 active site 262316003320 phosphorylation site [posttranslational modification] 262316003321 intermolecular recognition site; other site 262316003322 dimerization interface [polypeptide binding]; other site 262316003323 ANTAR domain; Region: ANTAR; cl04297 262316003324 lipid-transfer protein; Provisional; Region: PRK06059 262316003325 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316003326 active site 262316003327 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 262316003328 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 262316003329 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316003330 5'-3' exonuclease; Region: 53EXOc; smart00475 262316003331 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 262316003332 active site 262316003333 metal binding site 1 [ion binding]; metal-binding site 262316003334 putative 5' ssDNA interaction site; other site 262316003335 metal binding site 3; metal-binding site 262316003336 metal binding site 2 [ion binding]; metal-binding site 262316003337 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 262316003338 putative DNA binding site [nucleotide binding]; other site 262316003339 putative metal binding site [ion binding]; other site 262316003340 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 262316003341 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 262316003342 active site 262316003343 DNA binding site [nucleotide binding] 262316003344 catalytic site [active] 262316003345 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316003346 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 262316003347 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 262316003348 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 262316003349 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 262316003350 RNA binding site [nucleotide binding]; other site 262316003351 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 262316003352 RNA binding site [nucleotide binding]; other site 262316003353 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 262316003354 RNA binding site [nucleotide binding]; other site 262316003355 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 262316003356 RNA binding site [nucleotide binding]; other site 262316003357 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 262316003358 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 262316003359 CoA-binding site [chemical binding]; other site 262316003360 ATP-binding [chemical binding]; other site 262316003361 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 262316003362 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 262316003363 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 262316003364 DNA binding site [nucleotide binding] 262316003365 catalytic residue [active] 262316003366 H2TH interface [polypeptide binding]; other site 262316003367 putative catalytic residues [active] 262316003368 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 262316003369 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262316003370 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 262316003371 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 262316003372 active site 262316003373 DNA binding site [nucleotide binding] 262316003374 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 262316003375 DNA binding site [nucleotide binding] 262316003376 Protein of unknown function (DUF402); Region: DUF402; cl00979 262316003377 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316003378 phosphopeptide binding site; other site 262316003379 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316003380 phosphopeptide binding site; other site 262316003381 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 262316003382 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with...; Region: ABCG_EPDR; cd03213 262316003383 Walker A/P-loop; other site 262316003384 ATP binding site [chemical binding]; other site 262316003385 Q-loop/lid; other site 262316003386 ABC transporter signature motif; other site 262316003387 Walker B; other site 262316003388 D-loop; other site 262316003389 H-loop/switch region; other site 262316003390 ABC-2 type transporter; Region: ABC2_membrane; cl11417 262316003391 Protein kinase domain; Region: Pkinase; pfam00069 262316003392 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316003393 active site 262316003394 ATP binding site [chemical binding]; other site 262316003395 substrate binding site [chemical binding]; other site 262316003396 activation loop (A-loop); other site 262316003397 excinuclease ABC subunit B; Provisional; Region: PRK05298 262316003398 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316003399 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316003400 nucleotide binding region [chemical binding]; other site 262316003401 ATP-binding site [chemical binding]; other site 262316003402 Ultra-violet resistance protein B; Region: UvrB; pfam12344 262316003403 UvrB/uvrC motif; Region: UVR; pfam02151 262316003404 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 262316003405 MgtC family; Region: MgtC; cl12207 262316003406 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 262316003407 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 262316003408 Ligand Binding Site [chemical binding]; other site 262316003409 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316003410 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 262316003411 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 262316003412 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 262316003413 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 262316003414 Cytochrome P450; Region: p450; cl12078 262316003415 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 262316003416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316003417 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 262316003418 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262316003419 GAF domain; Region: GAF; cl00853 262316003420 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 262316003421 hypothetical protein; Provisional; Region: PRK07877 262316003422 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 262316003423 ATP binding site [chemical binding]; other site 262316003424 substrate interface [chemical binding]; other site 262316003425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316003426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316003427 Predicted esterase [General function prediction only]; Region: COG0627 262316003428 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316003429 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 262316003430 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 262316003431 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 262316003432 dimer interface [polypeptide binding]; other site 262316003433 putative anticodon binding site; other site 262316003434 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262316003435 motif 1; other site 262316003436 dimer interface [polypeptide binding]; other site 262316003437 active site 262316003438 motif 2; other site 262316003439 motif 3; other site 262316003440 translation initiation factor IF-3; Region: infC; TIGR00168 262316003441 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 262316003442 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 262316003443 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 262316003444 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 262316003445 23S rRNA binding site [nucleotide binding]; other site 262316003446 L21 binding site [polypeptide binding]; other site 262316003447 L13 binding site [polypeptide binding]; other site 262316003448 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 262316003449 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 262316003450 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 262316003451 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 262316003452 cyclase homology domain; Region: CHD; cd07302 262316003453 nucleotidyl binding site; other site 262316003454 metal binding site [ion binding]; metal-binding site 262316003455 dimer interface [polypeptide binding]; other site 262316003456 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 262316003457 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 262316003458 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 262316003459 dimer interface [polypeptide binding]; other site 262316003460 motif 1; other site 262316003461 active site 262316003462 motif 2; other site 262316003463 motif 3; other site 262316003464 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 262316003465 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 262316003466 putative tRNA-binding site [nucleotide binding]; other site 262316003467 B3/4 domain; Region: B3_4; cl11458 262316003468 tRNA synthetase B5 domain; Region: B5; cl08394 262316003469 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 262316003470 dimer interface [polypeptide binding]; other site 262316003471 motif 1; other site 262316003472 motif 3; other site 262316003473 motif 2; other site 262316003474 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 262316003475 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 262316003476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003477 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 262316003478 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 262316003479 heterotetramer interface [polypeptide binding]; other site 262316003480 active site pocket [active] 262316003481 cleavage site 262316003482 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 262316003483 feedback inhibition sensing region; other site 262316003484 homohexameric interface [polypeptide binding]; other site 262316003485 nucleotide binding site [chemical binding]; other site 262316003486 N-acetyl-L-glutamate binding site [chemical binding]; other site 262316003487 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 262316003488 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 262316003489 inhibitor-cofactor binding pocket; inhibition site 262316003490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316003491 catalytic residue [active] 262316003492 ornithine carbamoyltransferase; Provisional; Region: PRK00779 262316003493 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 262316003494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003495 arginine repressor; Region: argR_whole; TIGR01529 262316003496 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 262316003497 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 262316003498 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 262316003499 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 262316003500 ANP binding site [chemical binding]; other site 262316003501 Substrate Binding Site II [chemical binding]; other site 262316003502 Substrate Binding Site I [chemical binding]; other site 262316003503 argininosuccinate lyase; Provisional; Region: PRK00855 262316003504 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 262316003505 active sites [active] 262316003506 tetramer interface [polypeptide binding]; other site 262316003507 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 262316003508 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 262316003509 malonyl-CoA binding site [chemical binding]; other site 262316003510 dimer interface [polypeptide binding]; other site 262316003511 active site 262316003512 product binding site; other site 262316003513 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316003514 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 262316003515 active site 262316003516 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 262316003517 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316003518 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316003519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003520 Enoylreductase; Region: PKS_ER; smart00829 262316003521 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316003522 NAD(P) binding site [chemical binding]; other site 262316003523 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 262316003524 putative NADP binding site [chemical binding]; other site 262316003525 active site 262316003526 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316003527 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316003528 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 262316003529 active site 262316003530 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316003531 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316003532 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316003533 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 262316003534 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 262316003535 malonyl-CoA binding site [chemical binding]; other site 262316003536 dimer interface [polypeptide binding]; other site 262316003537 active site 262316003538 product binding site; other site 262316003539 Cytochrome P450; Region: p450; cl12078 262316003540 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 262316003541 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 262316003542 ABC transporter; Region: ABC_tran_2; pfam12848 262316003543 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316003544 Walker A/P-loop; other site 262316003545 ATP binding site [chemical binding]; other site 262316003546 Q-loop/lid; other site 262316003547 ABC transporter signature motif; other site 262316003548 Walker B; other site 262316003549 D-loop; other site 262316003550 H-loop/switch region; other site 262316003551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262316003552 putative active site [active] 262316003553 heme pocket [chemical binding]; other site 262316003554 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262316003555 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316003556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 262316003557 dimerization interface [polypeptide binding]; other site 262316003558 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 262316003559 classical (c) SDRs; Region: SDR_c; cd05233 262316003560 NAD(P) binding site [chemical binding]; other site 262316003561 active site 262316003562 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316003563 classical (c) SDRs; Region: SDR_c; cd05233 262316003564 NAD(P) binding site [chemical binding]; other site 262316003565 active site 262316003566 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316003567 classical (c) SDRs; Region: SDR_c; cd05233 262316003568 NAD(P) binding site [chemical binding]; other site 262316003569 active site 262316003570 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 262316003571 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved...; Region: MR_like_3; cd03328 262316003572 putative active site pocket [active] 262316003573 putative metal binding site [ion binding]; other site 262316003574 short chain dehydrogenase; Provisional; Region: PRK07109 262316003575 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 262316003576 putative NAD(P) binding site [chemical binding]; other site 262316003577 active site 262316003578 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 262316003579 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 262316003580 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 262316003581 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 262316003582 acyl-CoA synthetase; Validated; Region: PRK07868 262316003583 Trm112p-like protein; Region: Trm112p; cl01066 262316003584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316003585 ABC-2 type transporter; Region: ABC2_membrane; cl11417 262316003586 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 262316003587 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 262316003588 Walker A/P-loop; other site 262316003589 ATP binding site [chemical binding]; other site 262316003590 Q-loop/lid; other site 262316003591 ABC transporter signature motif; other site 262316003592 Walker B; other site 262316003593 D-loop; other site 262316003594 H-loop/switch region; other site 262316003595 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 262316003596 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 262316003597 active site 262316003598 DNA binding site [nucleotide binding] 262316003599 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 262316003600 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 262316003601 active site 262316003602 HIGH motif; other site 262316003603 dimer interface [polypeptide binding]; other site 262316003604 KMSKS motif; other site 262316003605 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 262316003606 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316003607 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 262316003608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 262316003609 active site 262316003610 motif I; other site 262316003611 motif II; other site 262316003612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 262316003613 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 262316003614 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 262316003615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316003616 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 262316003617 ATP-NAD kinase; Region: NAD_kinase; pfam01513 262316003618 DNA repair protein RecN; Region: recN; TIGR00634 262316003619 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316003620 Walker A/P-loop; other site 262316003621 ATP binding site [chemical binding]; other site 262316003622 Q-loop/lid; other site 262316003623 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 262316003624 ABC transporter signature motif; other site 262316003625 Walker B; other site 262316003626 D-loop; other site 262316003627 H-loop/switch region; other site 262316003628 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 262316003629 Thiamine pyrophosphokinase; Region: TPK; cl09135 262316003630 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 262316003631 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 262316003632 CTP synthetase; Validated; Region: pyrG; PRK05380 262316003633 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 262316003634 Catalytic site [active] 262316003635 Active site [active] 262316003636 UTP binding site [chemical binding]; other site 262316003637 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 262316003638 active site 262316003639 putative oxyanion hole; other site 262316003640 catalytic triad [active] 262316003641 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 262316003642 dimer interface [polypeptide binding]; other site 262316003643 ADP-ribose binding site [chemical binding]; other site 262316003644 active site 262316003645 nudix motif; other site 262316003646 metal binding site [ion binding]; metal-binding site 262316003647 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 262316003648 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316003649 DNA binding site [nucleotide binding] 262316003650 Int/Topo IB signature motif; other site 262316003651 active site 262316003652 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 262316003653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316003654 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 262316003655 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 262316003656 ScpA/B protein; Region: ScpA_ScpB; cl00598 262316003657 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 262316003658 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 262316003659 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262316003660 RNA binding surface [nucleotide binding]; other site 262316003661 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 262316003662 active site 262316003663 cytidylate kinase; Provisional; Region: cmk; PRK00023 262316003664 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 262316003665 CMP-binding site; other site 262316003666 The sites determining sugar specificity; other site 262316003667 GTP-binding protein Der; Reviewed; Region: PRK03003 262316003668 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 262316003669 G1 box; other site 262316003670 GTP/Mg2+ binding site [chemical binding]; other site 262316003671 Switch I region; other site 262316003672 G2 box; other site 262316003673 Switch II region; other site 262316003674 G3 box; other site 262316003675 G4 box; other site 262316003676 G5 box; other site 262316003677 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 262316003678 G1 box; other site 262316003679 GTP/Mg2+ binding site [chemical binding]; other site 262316003680 Switch I region; other site 262316003681 G2 box; other site 262316003682 G3 box; other site 262316003683 Switch II region; other site 262316003684 G4 box; other site 262316003685 G5 box; other site 262316003686 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 262316003687 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 262316003688 MbtH-like protein; Region: MbtH; cl01279 262316003689 Condensation domain; Region: Condensation; cl09290 262316003690 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316003691 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316003692 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316003693 Condensation domain; Region: Condensation; cl09290 262316003694 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 262316003695 Condensation domain; Region: Condensation; cl09290 262316003696 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316003697 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316003698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316003699 S-adenosylmethionine binding site [chemical binding]; other site 262316003700 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 262316003701 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316003702 Condensation domain; Region: Condensation; cl09290 262316003703 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 262316003704 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316003705 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316003706 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316003707 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316003708 Condensation domain; Region: Condensation; cl09290 262316003709 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316003710 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316003711 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316003712 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 262316003713 Condensation domain; Region: Condensation; cl09290 262316003714 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316003715 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316003716 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 262316003717 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 262316003718 active site 262316003719 dimer interface [polypeptide binding]; other site 262316003720 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 262316003721 Ligand Binding Site [chemical binding]; other site 262316003722 Molecular Tunnel; other site 262316003723 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 262316003724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316003725 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316003726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316003727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316003728 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 262316003729 Flavin Reductases; Region: FlaRed; cl00801 262316003730 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 262316003731 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 262316003732 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 262316003733 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 262316003734 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 262316003735 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 262316003736 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316003737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316003738 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316003739 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316003740 active site 262316003741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003742 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 262316003743 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316003744 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway...; Region: Rieske_RO_Alpha_KSH; cd03531 262316003745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003746 NAD(P) binding site [chemical binding]; other site 262316003747 active site 262316003748 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 262316003749 classical (c) SDRs; Region: SDR_c; cd05233 262316003750 NAD(P) binding site [chemical binding]; other site 262316003751 active site 262316003752 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316003753 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316003754 classical (c) SDRs; Region: SDR_c; cd05233 262316003755 NAD(P) binding site [chemical binding]; other site 262316003756 active site 262316003757 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316003758 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338 262316003759 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 262316003760 NAD(P) binding site [chemical binding]; other site 262316003761 homodimer interface [polypeptide binding]; other site 262316003762 active site 262316003763 Stress responsive A/B Barrel Domain; Region: Dabb; cl06768 262316003764 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316003765 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316003766 Transcriptional regulator [Transcription]; Region: IclR; COG1414 262316003767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316003768 Bacterial transcriptional regulator; Region: IclR; pfam01614 262316003769 hypothetical protein; Validated; Region: PRK07121 262316003770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003771 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316003772 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316003773 active site 262316003774 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316003775 classical (c) SDRs; Region: SDR_c; cd05233 262316003776 NAD(P) binding site [chemical binding]; other site 262316003777 active site 262316003778 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316003779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003780 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316003781 classical (c) SDRs; Region: SDR_c; cd05233 262316003782 NAD(P) binding site [chemical binding]; other site 262316003783 active site 262316003784 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 262316003785 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316003786 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316003787 Condensation domain; Region: Condensation; cl09290 262316003788 classical (c) SDRs; Region: SDR_c; cd05233 262316003789 NAD(P) binding site [chemical binding]; other site 262316003790 active site 262316003791 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316003792 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316003793 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316003794 phosphopeptide binding site; other site 262316003795 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 262316003796 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316003797 phosphopeptide binding site; other site 262316003798 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with...; Region: ABCG_EPDR; cd03213 262316003799 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262316003800 Walker A/P-loop; other site 262316003801 ATP binding site [chemical binding]; other site 262316003802 Q-loop/lid; other site 262316003803 ABC transporter signature motif; other site 262316003804 Walker B; other site 262316003805 D-loop; other site 262316003806 H-loop/switch region; other site 262316003807 ABC-2 type transporter; Region: ABC2_membrane; cl11417 262316003808 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316003809 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316003810 active site 262316003811 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316003812 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316003813 active site 262316003814 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 262316003815 active site 262316003816 catalytic site [active] 262316003817 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 262316003818 putative active site [active] 262316003819 putative catalytic site [active] 262316003820 thiolase; Provisional; Region: PRK06158 262316003821 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316003822 active site 262316003823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003824 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316003825 acyl-CoA synthetase; Provisional; Region: PRK13388 262316003826 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316003827 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316003828 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316003829 active site 262316003830 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262316003831 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262316003832 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 262316003833 active site 262316003834 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262316003835 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262316003836 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279 262316003837 active site 262316003838 short chain dehydrogenase; Provisional; Region: PRK06197 262316003839 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 262316003840 putative NAD(P) binding site [chemical binding]; other site 262316003841 active site 262316003842 Cytochrome P450; Region: p450; cl12078 262316003843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316003844 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316003845 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 262316003846 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316003847 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 262316003848 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 262316003849 DNA binding residues [nucleotide binding] 262316003850 classical (c) SDRs; Region: SDR_c; cd05233 262316003851 NAD(P) binding site [chemical binding]; other site 262316003852 active site 262316003853 Cutinase; Region: Cutinase; pfam01083 262316003854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316003855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316003856 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 262316003857 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316003858 active site 262316003859 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316003860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316003861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316003862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316003863 S-adenosylmethionine binding site [chemical binding]; other site 262316003864 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 262316003865 DEAD-like helicases superfamily; Region: DEXDc; smart00487 262316003866 ATP binding site [chemical binding]; other site 262316003867 Mg++ binding site [ion binding]; other site 262316003868 motif III; other site 262316003869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316003870 nucleotide binding region [chemical binding]; other site 262316003871 ATP-binding site [chemical binding]; other site 262316003872 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316003873 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316003874 substrate binding site [chemical binding]; other site 262316003875 oxyanion hole (OAH) forming residues; other site 262316003876 trimer interface [polypeptide binding]; other site 262316003877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003878 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 262316003879 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316003880 [2Fe-2S] cluster binding site [ion binding]; other site 262316003881 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 262316003882 putative alpha subunit interface [polypeptide binding]; other site 262316003883 putative active site [active] 262316003884 putative substrate binding site [chemical binding]; other site 262316003885 Fe binding site [ion binding]; other site 262316003886 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316003887 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316003888 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316003889 substrate binding site [chemical binding]; other site 262316003890 oxyanion hole (OAH) forming residues; other site 262316003891 trimer interface [polypeptide binding]; other site 262316003892 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 262316003893 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 262316003894 alpha subunit interface [polypeptide binding]; other site 262316003895 TPP binding site [chemical binding]; other site 262316003896 heterodimer interface [polypeptide binding]; other site 262316003897 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262316003898 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 262316003899 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 262316003900 tetramer interface [polypeptide binding]; other site 262316003901 TPP-binding site [chemical binding]; other site 262316003902 heterodimer interface [polypeptide binding]; other site 262316003903 phosphorylation loop region [posttranslational modification] 262316003904 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316003905 classical (c) SDRs; Region: SDR_c; cd05233 262316003906 NAD(P) binding site [chemical binding]; other site 262316003907 active site 262316003908 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316003909 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316003910 ANTAR domain; Region: ANTAR; cl04297 262316003911 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 262316003912 hydrophobic ligand binding site; other site 262316003913 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 262316003914 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 262316003915 Moco binding site; other site 262316003916 metal coordination site [ion binding]; other site 262316003917 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316003918 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 262316003919 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 262316003920 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 262316003921 Protein of unknown function (DUF690); Region: DUF690; cl04939 262316003922 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 262316003923 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316003924 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 262316003925 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316003926 Cytochrome P450; Region: p450; cl12078 262316003927 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 262316003928 PPE family; Region: PPE; pfam00823 262316003929 PPE family; Region: PPE; pfam00823 262316003930 PE family; Region: PE; pfam00934 262316003931 Proteins of 100 residues with WXG; Region: WXG100; cl02005 262316003932 secretion protein snm4; Region: sec_mycoba_snm4; TIGR02958 262316003933 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 262316003934 catalytic residues [active] 262316003935 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 262316003936 active site 262316003937 catalytic residues [active] 262316003938 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 262316003939 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 262316003940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316003941 Walker A motif; other site 262316003942 ATP binding site [chemical binding]; other site 262316003943 Walker B motif; other site 262316003944 arginine finger; other site 262316003945 PE family; Region: PE; pfam00934 262316003946 PPE family; Region: PPE; pfam00823 262316003947 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316003948 PPE family; Region: PPE; pfam00823 262316003949 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316003950 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316003951 PPE family; Region: PPE; pfam00823 262316003952 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316003953 PPE family; Region: PPE; pfam00823 262316003954 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316003955 PPE family; Region: PPE; pfam00823 262316003956 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316003957 PPE family; Region: PPE; pfam00823 262316003958 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316003959 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316003960 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 262316003961 MgtC family; Region: MgtC; cl12207 262316003962 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 262316003963 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 262316003964 active site 262316003965 metal binding site [ion binding]; metal-binding site 262316003966 hypothetical protein; Validated; Region: PRK07121 262316003967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003968 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 262316003969 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 262316003970 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 262316003971 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316003972 PYR/PP interface [polypeptide binding]; other site 262316003973 dimer interface [polypeptide binding]; other site 262316003974 TPP binding site [chemical binding]; other site 262316003975 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316003976 TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules...; Region: TPP_BZL_OCoD_HPCL; cd02004 262316003977 TPP-binding site; other site 262316003978 dimer interface [polypeptide binding]; other site 262316003979 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 262316003980 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 262316003981 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 262316003982 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 262316003983 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 262316003984 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 262316003985 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 262316003986 lipoyl attachment site [posttranslational modification]; other site 262316003987 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316003988 phosphopeptide binding site; other site 262316003989 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 262316003990 DNA binding residues [nucleotide binding] 262316003991 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 262316003992 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 262316003993 DNA binding residues [nucleotide binding] 262316003994 putative dimer interface [polypeptide binding]; other site 262316003995 glycine dehydrogenase; Provisional; Region: PRK05367 262316003996 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 262316003997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316003998 tetramer interface [polypeptide binding]; other site 262316003999 catalytic residue [active] 262316004000 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 262316004001 tetramer interface [polypeptide binding]; other site 262316004002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316004003 catalytic residue [active] 262316004004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004006 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 262316004007 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 262316004008 metal ion-dependent adhesion site (MIDAS); other site 262316004009 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 262316004010 active site 262316004011 Domain of unknown function DUF21; Region: DUF21; pfam01595 262316004012 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 262316004013 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 262316004014 Domain of unknown function DUF21; Region: DUF21; pfam01595 262316004015 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 262316004016 Transporter associated domain; Region: CorC_HlyC; cl08393 262316004017 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 262316004018 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316004019 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316004020 active site 262316004021 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 262316004022 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316004023 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316004024 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 262316004025 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 262316004026 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 262316004027 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 262316004028 active site 262316004029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004030 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 262316004031 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 262316004032 Peptidase family M48; Region: Peptidase_M48; cl12018 262316004033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316004034 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316004035 CoenzymeA binding site [chemical binding]; other site 262316004036 subunit interaction site [polypeptide binding]; other site 262316004037 PHB binding site; other site 262316004038 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 262316004039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004040 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316004041 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 262316004042 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316004043 classical (c) SDRs; Region: SDR_c; cd05233 262316004044 NAD(P) binding site [chemical binding]; other site 262316004045 active site 262316004046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316004047 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 262316004048 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 262316004049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316004050 putative PBP binding loops; other site 262316004051 ABC-ATPase subunit interface; other site 262316004052 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 262316004053 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316004054 Walker A/P-loop; other site 262316004055 ATP binding site [chemical binding]; other site 262316004056 Q-loop/lid; other site 262316004057 ABC transporter signature motif; other site 262316004058 Walker B; other site 262316004059 D-loop; other site 262316004060 H-loop/switch region; other site 262316004061 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 262316004062 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 262316004063 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 262316004064 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 262316004065 putative NAD(P) binding site [chemical binding]; other site 262316004066 putative substrate binding site [chemical binding]; other site 262316004067 catalytic Zn binding site [ion binding]; other site 262316004068 structural Zn binding site [ion binding]; other site 262316004069 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 262316004070 putative phosphoketolase; Provisional; Region: PRK05261 262316004071 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 262316004072 TPP-binding site; other site 262316004073 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 262316004074 XFP C-terminal domain; Region: XFP_C; pfam09363 262316004075 short chain dehydrogenase; Provisional; Region: PRK07825 262316004076 classical (c) SDRs; Region: SDR_c; cd05233 262316004077 NAD(P) binding site [chemical binding]; other site 262316004078 active site 262316004079 Bacitracin resistance protein BacA; Region: BacA; cl00858 262316004080 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316004081 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316004082 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 262316004083 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316004084 active site 262316004085 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316004086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004087 NAD(P) binding site [chemical binding]; other site 262316004088 active site 262316004089 hypothetical protein; Provisional; Region: PRK05865 262316004090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 262316004091 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 262316004092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004093 Protein of unknown function DUF72; Region: DUF72; cl00777 262316004094 uncharacterized HhH-GPD family protein; Region: TIGR03252 262316004095 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316004096 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 262316004097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316004098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316004099 Walker A motif; other site 262316004100 ATP binding site [chemical binding]; other site 262316004101 Walker B motif; other site 262316004102 arginine finger; other site 262316004103 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 262316004104 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 262316004105 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 262316004106 active site 262316004107 substrate binding site [chemical binding]; other site 262316004108 FMN binding site [chemical binding]; other site 262316004109 putative catalytic residues [active] 262316004110 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 262316004111 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 262316004112 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 262316004113 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 262316004114 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316004115 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 262316004116 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 262316004117 dimer interface [polypeptide binding]; other site 262316004118 decamer (pentamer of dimers) interface [polypeptide binding]; other site 262316004119 catalytic triad [active] 262316004120 peroxidatic and resolving cysteines [active] 262316004121 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 262316004122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316004123 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 262316004124 dimerization interface [polypeptide binding]; other site 262316004125 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316004126 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316004127 substrate binding site [chemical binding]; other site 262316004128 oxyanion hole (OAH) forming residues; other site 262316004129 trimer interface [polypeptide binding]; other site 262316004130 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 262316004131 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 262316004132 Ferritin-like domain; Region: Ferritin; pfam00210 262316004133 heme binding site [chemical binding]; other site 262316004134 ferroxidase pore; other site 262316004135 ferroxidase diiron center [ion binding]; other site 262316004136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316004137 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262316004138 putative substrate translocation pore; other site 262316004139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316004140 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316004141 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 262316004142 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316004143 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 262316004144 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 262316004145 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316004146 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316004147 Cytochrome P450; Region: p450; cl12078 262316004148 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 262316004149 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262316004150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004151 NAD(P) binding site [chemical binding]; other site 262316004152 active site 262316004153 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316004154 hydrophobic ligand binding site; other site 262316004155 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 262316004156 Chorismate mutase type II; Region: CM_2; cl00693 262316004157 Putative esterase; Region: Esterase; pfam00756 262316004158 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316004159 YceI-like domain; Region: YceI; cl01001 262316004160 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 262316004161 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 262316004162 putative NAD(P) binding site [chemical binding]; other site 262316004163 putative substrate binding site [chemical binding]; other site 262316004164 catalytic Zn binding site [ion binding]; other site 262316004165 structural Zn binding site [ion binding]; other site 262316004166 Cytochrome P450; Region: p450; cl12078 262316004167 Nitronate monooxygenase; Region: NMO; pfam03060 262316004168 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 262316004169 FMN binding site [chemical binding]; other site 262316004170 substrate binding site [chemical binding]; other site 262316004171 putative catalytic residue [active] 262316004172 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316004173 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316004174 active site 262316004175 putative selenate reductase, YgfK subunit; Region: Se_ygfK; TIGR03315 262316004176 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316004177 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 262316004178 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262316004179 NAD(P) binding site [chemical binding]; other site 262316004180 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316004181 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 262316004182 putative active site [active] 262316004183 dimerization interface [polypeptide binding]; other site 262316004184 putative tRNAtyr binding site [nucleotide binding]; other site 262316004185 Domain of unknown function DUF77; Region: DUF77; cl00307 262316004186 competence damage-inducible protein A; Provisional; Region: PRK00549 262316004187 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 262316004188 putative MPT binding site; other site 262316004189 Competence-damaged protein; Region: CinA; cl00666 262316004190 putative sialic acid transporter; Region: 2A0112; TIGR00891 262316004191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316004192 putative substrate translocation pore; other site 262316004193 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316004194 Membrane protein of unknown function; Region: DUF360; cl00850 262316004195 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 262316004196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004199 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262316004200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316004201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316004202 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 262316004203 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316004204 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 262316004205 putative dimerization interface [polypeptide binding]; other site 262316004206 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 262316004207 Flavoprotein; Region: Flavoprotein; cl08021 262316004208 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 262316004209 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 262316004210 substrate binding site [chemical binding]; other site 262316004211 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 262316004212 putative hydrophobic ligand binding site [chemical binding]; other site 262316004213 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 262316004214 putative hydrophobic ligand binding site [chemical binding]; other site 262316004215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262316004216 dimerization interface [polypeptide binding]; other site 262316004217 putative DNA binding site [nucleotide binding]; other site 262316004218 putative Zn2+ binding site [ion binding]; other site 262316004219 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316004220 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 262316004221 tetramer interface [polypeptide binding]; other site 262316004222 active site 262316004223 Mg2+/Mn2+ binding site [ion binding]; other site 262316004224 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 262316004225 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316004226 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 262316004227 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 262316004228 putative hydrophobic ligand binding site [chemical binding]; other site 262316004229 protein interface [polypeptide binding]; other site 262316004230 gate; other site 262316004231 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 262316004232 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316004233 short chain dehydrogenase; Provisional; Region: PRK05867 262316004234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004235 NAD(P) binding site [chemical binding]; other site 262316004236 active site 262316004237 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316004238 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 262316004239 conserved cys residue [active] 262316004240 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 262316004241 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 262316004242 conserved cys residue [active] 262316004243 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 262316004244 dimer interface [polypeptide binding]; other site 262316004245 catalytic triad [active] 262316004246 peroxidatic and resolving cysteines [active] 262316004247 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 262316004248 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 262316004249 FMN binding site [chemical binding]; other site 262316004250 substrate binding site [chemical binding]; other site 262316004251 putative catalytic residue [active] 262316004252 YacP-like NYN domain; Region: NYN_YacP; cl01491 262316004253 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316004254 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316004255 active site 262316004256 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 262316004257 extended (e) SDRs; Region: SDR_e; cd08946 262316004258 NAD(P) binding site [chemical binding]; other site 262316004259 active site 262316004260 substrate binding site [chemical binding]; other site 262316004261 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316004262 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316004263 NAD(P) binding site [chemical binding]; other site 262316004264 catalytic residues [active] 262316004265 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316004266 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 262316004267 active site 262316004268 catalytic residues [active] 262316004269 Cutinase; Region: Cutinase; pfam01083 262316004270 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 262316004271 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 262316004272 Protein of unknown function, DUF608; Region: DUF608; pfam04685 262316004273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316004274 S-adenosylmethionine binding site [chemical binding]; other site 262316004275 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316004276 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316004277 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 262316004278 active site 262316004279 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 262316004280 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 262316004281 dimer interface [polypeptide binding]; other site 262316004282 active site 262316004283 heme binding site [chemical binding]; other site 262316004284 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 262316004285 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 262316004286 metal binding site 2 [ion binding]; metal-binding site 262316004287 putative DNA binding helix; other site 262316004288 metal binding site 1 [ion binding]; metal-binding site 262316004289 dimer interface [polypeptide binding]; other site 262316004290 structural Zn2+ binding site [ion binding]; other site 262316004291 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 262316004292 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 262316004293 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 262316004294 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 262316004295 iron-sulfur cluster [ion binding]; other site 262316004296 [2Fe-2S] cluster binding site [ion binding]; other site 262316004297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316004298 S-adenosylmethionine binding site [chemical binding]; other site 262316004299 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 262316004300 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 262316004301 homodimer interface [polypeptide binding]; other site 262316004302 active site 262316004303 TDP-binding site; other site 262316004304 acceptor substrate-binding pocket; other site 262316004305 PPE family; Region: PPE; pfam00823 262316004306 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316004307 PPE family; Region: PPE; pfam00823 262316004308 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 262316004309 putative active site [active] 262316004310 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 262316004311 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 262316004312 MOSC domain; Region: MOSC; pfam03473 262316004313 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 262316004314 Cutinase; Region: Cutinase; pfam01083 262316004315 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316004316 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316004317 substrate binding site [chemical binding]; other site 262316004318 oxyanion hole (OAH) forming residues; other site 262316004319 trimer interface [polypeptide binding]; other site 262316004320 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262316004321 metal binding site [ion binding]; metal-binding site 262316004322 active site 262316004323 I-site; other site 262316004324 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 262316004325 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316004326 ATP binding site [chemical binding]; other site 262316004327 putative Mg++ binding site [ion binding]; other site 262316004328 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316004329 nucleotide binding region [chemical binding]; other site 262316004330 ATP-binding site [chemical binding]; other site 262316004331 Helicase associated domain (HA2); Region: HA2; cl04503 262316004332 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 262316004333 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 262316004334 hypothetical protein; Provisional; Region: PRK06834 262316004335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004338 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 262316004339 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 262316004340 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 262316004341 hydrolase, peptidase M42 family; Region: trio_M42_hydro; TIGR03106 262316004342 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 262316004343 putative oligomer interface [polypeptide binding]; other site 262316004344 putative active site [active] 262316004345 metal binding site [ion binding]; metal-binding site 262316004346 phosphoethanolamine N-methyltransferase; Region: PLN02336 262316004347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316004348 S-adenosylmethionine binding site [chemical binding]; other site 262316004349 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 262316004350 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316004351 classical (c) SDRs; Region: SDR_c; cd05233 262316004352 NAD(P) binding site [chemical binding]; other site 262316004353 active site 262316004354 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 262316004355 Condensation domain; Region: Condensation; cl09290 262316004356 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 262316004357 HSP70 interaction site [polypeptide binding]; other site 262316004358 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 262316004359 putative dimer interface [polypeptide binding]; other site 262316004360 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 262316004361 DNA binding residues [nucleotide binding] 262316004362 putative dimer interface [polypeptide binding]; other site 262316004363 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 262316004364 putative dimer interface [polypeptide binding]; other site 262316004365 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 262316004366 THUMP domain; Region: THUMP; cl12076 262316004367 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 262316004368 Ligand Binding Site [chemical binding]; other site 262316004369 Beta-lactamase; Region: Beta-lactamase; cl01009 262316004370 biotin carboxylase-like protein; Validated; Region: PRK06524 262316004371 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316004372 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 262316004373 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316004374 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 262316004375 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 262316004376 Cellulose binding domain; Region: CBM_2; cl02709 262316004377 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316004378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004379 NAD(P) binding site [chemical binding]; other site 262316004380 active site 262316004381 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 262316004382 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 262316004383 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316004384 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316004385 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316004386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004388 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316004389 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316004390 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316004391 active site 262316004392 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 262316004393 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316004394 dimer interface [polypeptide binding]; other site 262316004395 active site 262316004396 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 262316004397 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316004398 substrate binding site [chemical binding]; other site 262316004399 oxyanion hole (OAH) forming residues; other site 262316004400 trimer interface [polypeptide binding]; other site 262316004401 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262316004402 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 262316004403 short chain dehydrogenase; Provisional; Region: PRK07825 262316004404 classical (c) SDRs; Region: SDR_c; cd05233 262316004405 NAD(P) binding site [chemical binding]; other site 262316004406 active site 262316004407 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 262316004408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004410 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 262316004411 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316004412 putative NAD(P) binding site [chemical binding]; other site 262316004413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004415 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316004416 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316004417 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 262316004418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004419 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 262316004420 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 262316004421 putative heme binding pocket [chemical binding]; other site 262316004422 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004424 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316004425 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316004426 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316004427 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 262316004428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 262316004429 motif II; other site 262316004430 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 262316004431 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 262316004432 active site 262316004433 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 262316004434 catalytic triad [active] 262316004435 dimer interface [polypeptide binding]; other site 262316004436 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 262316004437 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 262316004438 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 262316004439 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 262316004440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004442 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316004443 PPE family; Region: PPE; pfam00823 262316004444 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316004445 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316004446 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316004447 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 262316004448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004449 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316004450 Transport protein; Region: actII; TIGR00833 262316004451 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 262316004452 homotetramer interface [polypeptide binding]; other site 262316004453 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316004454 NAD binding site [chemical binding]; other site 262316004455 homodimer interface [polypeptide binding]; other site 262316004456 active site 262316004457 PAS domain S-box; Region: sensory_box; TIGR00229 262316004458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 262316004459 PAS domain S-box; Region: sensory_box; TIGR00229 262316004460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262316004461 putative active site [active] 262316004462 heme pocket [chemical binding]; other site 262316004463 Histidine kinase; Region: HisKA_3; pfam07730 262316004464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316004465 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 262316004466 Ligand Binding Site [chemical binding]; other site 262316004467 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 262316004468 Ligand Binding Site [chemical binding]; other site 262316004469 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 262316004470 Ligand Binding Site [chemical binding]; other site 262316004471 hypothetical protein; Provisional; Region: PRK07877 262316004472 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 262316004473 FMN binding site [chemical binding]; other site 262316004474 dimer interface [polypeptide binding]; other site 262316004475 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 262316004476 hypothetical protein; Provisional; Region: PRK07877 262316004477 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 262316004478 FMN binding site [chemical binding]; other site 262316004479 dimer interface [polypeptide binding]; other site 262316004480 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316004481 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316004482 active site 262316004483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004484 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316004485 NAD(P) binding site [chemical binding]; other site 262316004486 active site 262316004487 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 262316004488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 262316004489 active site 262316004490 catalytic tetrad [active] 262316004491 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 262316004492 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 262316004493 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 262316004494 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316004495 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 262316004496 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316004497 OsmC-like protein; Region: OsmC; cl00767 262316004498 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 262316004499 Imelysin; Region: Peptidase_M75; cl09159 262316004500 Iron permease FTR1 family; Region: FTR1; cl00475 262316004501 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 262316004502 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 262316004503 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 262316004504 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 262316004505 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 262316004506 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 262316004507 Walker A/P-loop; other site 262316004508 ATP binding site [chemical binding]; other site 262316004509 Q-loop/lid; other site 262316004510 ABC transporter signature motif; other site 262316004511 Walker B; other site 262316004512 D-loop; other site 262316004513 H-loop/switch region; other site 262316004514 TOBE domain; Region: TOBE_2; cl01440 262316004515 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 262316004516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316004517 dimer interface [polypeptide binding]; other site 262316004518 conserved gate region; other site 262316004519 putative PBP binding loops; other site 262316004520 ABC-ATPase subunit interface; other site 262316004521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316004522 dimer interface [polypeptide binding]; other site 262316004523 conserved gate region; other site 262316004524 putative PBP binding loops; other site 262316004525 ABC-ATPase subunit interface; other site 262316004526 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316004527 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 262316004528 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316004529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 262316004530 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316004531 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316004532 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316004533 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 262316004534 Isochorismatase family; Region: Isochorismatase; pfam00857 262316004535 catalytic triad [active] 262316004536 conserved cis-peptide bond; other site 262316004537 DoxX; Region: DoxX; cl00976 262316004538 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316004539 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 262316004540 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 262316004541 Phosphotransferase enzyme family; Region: APH; pfam01636 262316004542 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316004543 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 262316004544 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316004545 substrate binding pocket [chemical binding]; other site 262316004546 catalytic triad [active] 262316004547 Cytochrome P450; Region: p450; cl12078 262316004548 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004549 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316004550 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316004551 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316004552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004553 classical (c) SDRs; Region: SDR_c; cd05233 262316004554 NAD(P) binding site [chemical binding]; other site 262316004555 active site 262316004556 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 262316004557 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 262316004558 metal ion-dependent adhesion site (MIDAS); other site 262316004559 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316004560 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 262316004561 Walker A motif; other site 262316004562 ATP binding site [chemical binding]; other site 262316004563 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 262316004564 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316004565 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316004566 hypothetical protein; Provisional; Region: PRK05865 262316004567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004568 NAD(P) binding site [chemical binding]; other site 262316004569 active site 262316004570 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 262316004571 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 262316004572 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316004573 active site 262316004574 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316004575 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316004576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004577 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316004578 Enoylreductase; Region: PKS_ER; smart00829 262316004579 NAD(P) binding site [chemical binding]; other site 262316004580 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 262316004581 putative NADP binding site [chemical binding]; other site 262316004582 active site 262316004583 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316004584 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 262316004585 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316004586 active site 262316004587 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316004588 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316004589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004590 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316004591 Enoylreductase; Region: PKS_ER; smart00829 262316004592 NAD(P) binding site [chemical binding]; other site 262316004593 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 262316004594 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 262316004595 putative NADP binding site [chemical binding]; other site 262316004596 active site 262316004597 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316004598 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 262316004599 Ligand binding site [chemical binding]; other site 262316004600 Putative Catalytic site [active] 262316004601 DXD motif; other site 262316004602 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 262316004603 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 262316004604 putative active site [active] 262316004605 catalytic triad [active] 262316004606 putative dimer interface [polypeptide binding]; other site 262316004607 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 262316004608 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316004609 active site 262316004610 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 262316004611 Dienelactone hydrolase family; Region: DLH; pfam01738 262316004612 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316004613 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316004614 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 262316004615 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316004616 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 262316004617 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 262316004618 substrate binding pocket [chemical binding]; other site 262316004619 membrane-bound complex binding site; other site 262316004620 hinge residues; other site 262316004621 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 262316004622 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 262316004623 Walker A/P-loop; other site 262316004624 ATP binding site [chemical binding]; other site 262316004625 Q-loop/lid; other site 262316004626 ABC transporter signature motif; other site 262316004627 Walker B; other site 262316004628 D-loop; other site 262316004629 H-loop/switch region; other site 262316004630 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 262316004631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316004632 dimer interface [polypeptide binding]; other site 262316004633 conserved gate region; other site 262316004634 putative PBP binding loops; other site 262316004635 ABC-ATPase subunit interface; other site 262316004636 precorrin-3B synthase; Region: CobG; TIGR02435 262316004637 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316004638 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316004639 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 262316004640 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 262316004641 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 262316004642 PPE family; Region: PPE; pfam00823 262316004643 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 262316004644 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 262316004645 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316004646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 262316004647 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 262316004648 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 262316004649 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 262316004650 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 262316004651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316004652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004653 classical (c) SDRs; Region: SDR_c; cd05233 262316004654 NAD(P) binding site [chemical binding]; other site 262316004655 active site 262316004656 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316004657 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262316004658 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262316004659 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279 262316004660 active site 262316004661 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262316004662 Integrase core domain; Region: rve; cl01316 262316004663 5'-3' exonuclease; Region: 53EXOc; smart00475 262316004664 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 262316004665 active site 262316004666 metal binding site 1 [ion binding]; metal-binding site 262316004667 putative 5' ssDNA interaction site; other site 262316004668 metal binding site 3; metal-binding site 262316004669 metal binding site 2 [ion binding]; metal-binding site 262316004670 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 262316004671 putative DNA binding site [nucleotide binding]; other site 262316004672 putative metal binding site [ion binding]; other site 262316004673 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 262316004674 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 262316004675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316004676 ATP binding site [chemical binding]; other site 262316004677 putative Mg++ binding site [ion binding]; other site 262316004678 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316004679 nucleotide binding region [chemical binding]; other site 262316004680 ATP-binding site [chemical binding]; other site 262316004681 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 262316004682 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 262316004683 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 262316004684 Predicted transcriptional regulator [Transcription]; Region: COG2378 262316004685 Predicted transcriptional regulator [Transcription]; Region: COG2378 262316004686 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 262316004687 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 262316004688 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 262316004689 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 262316004690 active site 262316004691 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 262316004692 active site 262316004693 Pup-like protein; Region: Pup; cl05289 262316004694 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 262316004695 Pup-ligase protein; Region: Pup_ligase; pfam03136 262316004696 Protein of unknown function (DUF503); Region: DUF503; cl00669 262316004697 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 262316004698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316004699 S-adenosylmethionine binding site [chemical binding]; other site 262316004700 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 262316004701 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 262316004702 mercuric reductase; Validated; Region: PRK06370 262316004703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004705 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262316004706 Predicted membrane protein [Function unknown]; Region: COG3918 262316004707 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 262316004708 ATP phosphoribosyltransferase; Region: HisG; cl15266 262316004709 HisG, C-terminal domain; Region: HisG_C; cl06867 262316004710 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 262316004711 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 262316004712 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004713 Domain of unknown function DUF140; Region: DUF140; cl00510 262316004714 Domain of unknown function DUF140; Region: DUF140; cl00510 262316004715 mce related protein; Region: MCE; pfam02470 262316004716 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316004717 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316004718 mce related protein; Region: MCE; pfam02470 262316004719 mce related protein; Region: MCE; pfam02470 262316004720 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316004721 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316004722 mce related protein; Region: MCE; pfam02470 262316004723 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316004724 mce related protein; Region: MCE; pfam02470 262316004725 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316004726 mce related protein; Region: MCE; pfam02470 262316004727 Mannan-binding protein; Region: MVL; pfam12151 262316004728 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 262316004729 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 262316004730 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 262316004731 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 262316004732 substrate binding pocket [chemical binding]; other site 262316004733 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 262316004734 B12 binding site [chemical binding]; other site 262316004735 cobalt ligand [ion binding]; other site 262316004736 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 262316004737 PAC2 family; Region: PAC2; cl00847 262316004738 short chain dehydrogenase; Provisional; Region: PRK05872 262316004739 classical (c) SDRs; Region: SDR_c; cd05233 262316004740 NAD(P) binding site [chemical binding]; other site 262316004741 active site 262316004742 AMP-binding enzyme; Region: AMP-binding; pfam00501 262316004743 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316004744 acyl-CoA synthetase; Validated; Region: PRK05850 262316004745 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316004746 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 262316004747 FAD binding pocket [chemical binding]; other site 262316004748 FAD binding motif [chemical binding]; other site 262316004749 phosphate binding motif [ion binding]; other site 262316004750 NAD binding pocket [chemical binding]; other site 262316004751 Cytochrome P450; Region: p450; cl12078 262316004752 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316004753 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 262316004754 active site 262316004755 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316004756 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316004757 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316004758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004759 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316004760 Enoylreductase; Region: PKS_ER; smart00829 262316004761 NAD(P) binding site [chemical binding]; other site 262316004762 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 262316004763 putative NADP binding site [chemical binding]; other site 262316004764 active site 262316004765 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316004766 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 262316004767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316004768 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 262316004769 peptide synthase; Provisional; Region: PRK12467 262316004770 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316004771 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316004772 Condensation domain; Region: Condensation; cl09290 262316004773 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 262316004774 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316004775 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316004776 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316004777 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316004778 Condensation domain; Region: Condensation; cl09290 262316004779 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316004780 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316004781 MbtH-like protein; Region: MbtH; cl01279 262316004782 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 262316004783 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316004784 PYR/PP interface [polypeptide binding]; other site 262316004785 dimer interface [polypeptide binding]; other site 262316004786 TPP binding site [chemical binding]; other site 262316004787 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 262316004788 TPP-binding site [chemical binding]; other site 262316004789 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316004790 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 262316004791 DNA binding residues [nucleotide binding] 262316004792 dimerization interface [polypeptide binding]; other site 262316004793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316004794 Walker A motif; other site 262316004795 ATP binding site [chemical binding]; other site 262316004796 Predicted ATPase [General function prediction only]; Region: COG3899 262316004797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 262316004798 DNA binding residues [nucleotide binding] 262316004799 dimerization interface [polypeptide binding]; other site 262316004800 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316004801 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 262316004802 active site 262316004803 HIGH motif; other site 262316004804 nucleotide binding site [chemical binding]; other site 262316004805 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316004806 active site 262316004807 KMSKS motif; other site 262316004808 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 262316004809 putative tRNA binding surface [nucleotide binding]; other site 262316004810 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 262316004811 active site 262316004812 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (...; Region: PI3Kc_like; cl00119 262316004813 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 262316004814 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316004815 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 262316004816 catalytic core [active] 262316004817 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 262316004818 quinone interaction residues [chemical binding]; other site 262316004819 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 262316004820 active site 262316004821 catalytic residues [active] 262316004822 FMN binding site [chemical binding]; other site 262316004823 substrate binding site [chemical binding]; other site 262316004824 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316004825 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316004826 active site 262316004827 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 262316004828 substrate binding site [chemical binding]; other site 262316004829 hypothetical protein; Provisional; Region: PRK07906 262316004830 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 262316004831 putative metal binding site [ion binding]; other site 262316004832 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 262316004833 DivIVA domain; Region: DivI1A_domain; TIGR03544 262316004834 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 262316004835 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 262316004836 YGGT family; Region: YGGT; cl00508 262316004837 Protein of unknown function (DUF552); Region: DUF552; cl00775 262316004838 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 262316004839 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 262316004840 catalytic residue [active] 262316004841 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 262316004842 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 262316004843 cell division protein FtsZ; Validated; Region: PRK09330 262316004844 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 262316004845 nucleotide binding site [chemical binding]; other site 262316004846 SulA interaction site; other site 262316004847 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 262316004848 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 262316004849 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262316004850 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262316004851 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 262316004852 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 262316004853 active site 262316004854 homodimer interface [polypeptide binding]; other site 262316004855 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 262316004856 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 262316004857 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262316004858 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262316004859 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 262316004860 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 262316004861 Mg++ binding site [ion binding]; other site 262316004862 putative catalytic motif [active] 262316004863 putative substrate binding site [chemical binding]; other site 262316004864 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262316004865 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262316004866 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 262316004867 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 262316004868 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262316004869 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262316004870 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 262316004871 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 262316004872 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 262316004873 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 262316004874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316004875 cell division protein MraZ; Reviewed; Region: PRK00326 262316004876 MraZ protein; Region: MraZ; pfam02381 262316004877 MraZ protein; Region: MraZ; pfam02381 262316004878 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 262316004879 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 262316004880 substrate binding pocket [chemical binding]; other site 262316004881 chain length determination region; other site 262316004882 substrate-Mg2+ binding site; other site 262316004883 catalytic residues [active] 262316004884 aspartate-rich region 1; other site 262316004885 active site lid residues [active] 262316004886 aspartate-rich region 2; other site 262316004887 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 262316004888 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316004889 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316004890 active site 262316004891 ATP binding site [chemical binding]; other site 262316004892 substrate binding site [chemical binding]; other site 262316004893 activation loop (A-loop); other site 262316004894 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 262316004895 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 262316004896 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 262316004897 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 262316004898 putative acyl-acceptor binding pocket; other site 262316004899 arsenite-activated ATPase ArsA; Region: arsA; TIGR00345 262316004900 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 262316004901 DTAP/Switch II; other site 262316004902 Switch I; other site 262316004903 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 262316004904 putative hydrophobic ligand binding site [chemical binding]; other site 262316004905 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 262316004906 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316004907 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316004908 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316004909 NlpC/P60 family; Region: NLPC_P60; cl11438 262316004910 hypothetical protein; Validated; Region: PRK07883 262316004911 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 262316004912 active site 262316004913 substrate binding site [chemical binding]; other site 262316004914 catalytic site [active] 262316004915 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 262316004916 GIY-YIG motif/motif A; other site 262316004917 active site 262316004918 catalytic site [active] 262316004919 putative DNA binding site [nucleotide binding]; other site 262316004920 metal binding site [ion binding]; metal-binding site 262316004921 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 262316004922 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 262316004923 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 262316004924 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 262316004925 Subunit I/III interface [polypeptide binding]; other site 262316004926 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 262316004927 Cytochrome c; Region: Cytochrom_C; cl11414 262316004928 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 262316004929 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 262316004930 iron-sulfur cluster [ion binding]; other site 262316004931 [2Fe-2S] cluster binding site [ion binding]; other site 262316004932 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 262316004933 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 262316004934 heme bH binding site [chemical binding]; other site 262316004935 intrachain domain interface; other site 262316004936 heme bL binding site [chemical binding]; other site 262316004937 interchain domain interface [polypeptide binding]; other site 262316004938 Qo binding site; other site 262316004939 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 262316004940 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316004941 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 262316004942 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 262316004943 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 262316004944 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 262316004945 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 262316004946 dimer interface [polypeptide binding]; other site 262316004947 active site 262316004948 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 262316004949 Ligand Binding Site [chemical binding]; other site 262316004950 Molecular Tunnel; other site 262316004951 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 262316004952 substrate binding site [chemical binding]; other site 262316004953 ATP binding site [chemical binding]; other site 262316004954 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 262316004955 Glycerate kinase family; Region: Gly_kinase; cl00841 262316004956 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 262316004957 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 262316004958 homotrimer interface [polypeptide binding]; other site 262316004959 Walker A motif; other site 262316004960 GTP binding site [chemical binding]; other site 262316004961 Walker B motif; other site 262316004962 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 262316004963 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 262316004964 putative dimer interface [polypeptide binding]; other site 262316004965 active site pocket [active] 262316004966 putative cataytic base [active] 262316004967 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 262316004968 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 262316004969 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 262316004970 homodimer interface [polypeptide binding]; other site 262316004971 substrate-cofactor binding pocket; other site 262316004972 catalytic residue [active] 262316004973 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 262316004974 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 262316004975 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316004976 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316004977 multifunctional aminopeptidase A; Provisional; Region: PRK00913 262316004978 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 262316004979 interface (dimer of trimers) [polypeptide binding]; other site 262316004980 Substrate-binding/catalytic site; other site 262316004981 Zn-binding sites [ion binding]; other site 262316004982 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316004983 hydrophobic ligand binding site; other site 262316004984 short chain dehydrogenase; Validated; Region: PRK05855 262316004985 classical (c) SDRs; Region: SDR_c; cd05233 262316004986 NAD(P) binding site [chemical binding]; other site 262316004987 active site 262316004988 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 262316004989 E3 interaction surface; other site 262316004990 lipoyl attachment site [posttranslational modification]; other site 262316004991 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 262316004992 E3 interaction surface; other site 262316004993 lipoyl attachment site [posttranslational modification]; other site 262316004994 e3 binding domain; Region: E3_binding; pfam02817 262316004995 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 262316004996 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 262316004997 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 262316004998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004999 NAD(P) binding site [chemical binding]; other site 262316005000 active site 262316005001 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 262316005002 lipoyl synthase; Provisional; Region: PRK05481 262316005003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 262316005004 FeS/SAM binding site; other site 262316005005 RDD family; Region: RDD; cl00746 262316005006 glutamine synthetase, type I; Region: GlnA; TIGR00653 262316005007 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 262316005008 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 262316005009 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 262316005010 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316005011 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316005012 CoenzymeA binding site [chemical binding]; other site 262316005013 subunit interaction site [polypeptide binding]; other site 262316005014 PHB binding site; other site 262316005015 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 262316005016 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 262316005017 metal binding triad; other site 262316005018 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 262316005019 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 262316005020 metal binding triad; other site 262316005021 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 262316005022 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 262316005023 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 262316005024 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 262316005025 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 262316005026 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316005027 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 262316005028 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316005029 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316005030 Condensation domain; Region: Condensation; cl09290 262316005031 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 262316005032 oligomerization interface [polypeptide binding]; other site 262316005033 active site 262316005034 metal binding site [ion binding]; metal-binding site 262316005035 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895 262316005036 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 262316005037 putative active site; other site 262316005038 putative metal binding residues [ion binding]; other site 262316005039 signature motif; other site 262316005040 putative triphosphate binding site [ion binding]; other site 262316005041 CHAD domain; Region: CHAD; cl10506 262316005042 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 262316005043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316005044 S-adenosylmethionine binding site [chemical binding]; other site 262316005045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316005046 sequence-specific DNA binding site [nucleotide binding]; other site 262316005047 salt bridge; other site 262316005048 Cupin domain; Region: Cupin_2; cl09118 262316005049 Cytochrome P450; Region: p450; cl12078 262316005050 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 262316005051 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 262316005052 RNA/DNA hybrid binding site [nucleotide binding]; other site 262316005053 active site 262316005054 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316005055 catalytic core [active] 262316005056 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 262316005057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 262316005058 Putative zinc ribbon domain; Region: DUF164; pfam02591 262316005059 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 262316005060 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 262316005061 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 262316005062 hypothetical protein; Provisional; Region: PRK07908 262316005063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316005064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316005065 homodimer interface [polypeptide binding]; other site 262316005066 catalytic residue [active] 262316005067 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 262316005068 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 262316005069 motif II; other site 262316005070 Low molecular weight phosphatase family; Region: LMWPc; cd00115 262316005071 Active site [active] 262316005072 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 262316005073 CobD/Cbib protein; Region: CobD_Cbib; cl00561 262316005074 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 262316005075 Epoxide hydrolase N terminus; Region: EHN; pfam06441 262316005076 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 262316005077 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 262316005078 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 262316005079 dimer interface [polypeptide binding]; other site 262316005080 catalytic triad [active] 262316005081 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 262316005082 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 262316005083 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 262316005084 dimer interface [polypeptide binding]; other site 262316005085 TPP-binding site [chemical binding]; other site 262316005086 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 262316005087 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316005088 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316005089 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316005090 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 262316005091 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 262316005092 dimer interface [polypeptide binding]; other site 262316005093 active site 262316005094 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 262316005095 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 262316005096 dimer interface [polypeptide binding]; other site 262316005097 active site 262316005098 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316005099 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 262316005100 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316005101 hypothetical protein; Provisional; Region: PRK06126 262316005102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005103 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 262316005104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316005105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316005106 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 262316005107 FAD binding domain; Region: FAD_binding_4; pfam01565 262316005108 diacylglycerol kinase; Reviewed; Region: PRK11914 262316005109 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 262316005110 Beta-lactamase; Region: Beta-lactamase; cl01009 262316005111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316005112 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 262316005113 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 262316005114 NAD binding site [chemical binding]; other site 262316005115 catalytic Zn binding site [ion binding]; other site 262316005116 substrate binding site [chemical binding]; other site 262316005117 structural Zn binding site [ion binding]; other site 262316005118 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316005119 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 262316005120 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 262316005121 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316005122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005123 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316005124 Cytochrome P450; Region: p450; cl12078 262316005125 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316005126 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316005127 Cutinase; Region: Cutinase; pfam01083 262316005128 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 262316005129 active site 262316005130 metal binding site [ion binding]; metal-binding site 262316005131 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316005132 active site 262316005133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316005134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316005135 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316005136 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316005137 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316005138 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316005139 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316005140 active site 262316005141 ATP binding site [chemical binding]; other site 262316005142 substrate binding site [chemical binding]; other site 262316005143 activation loop (A-loop); other site 262316005144 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 262316005145 oligomeric interface; other site 262316005146 putative active site [active] 262316005147 homodimer interface [polypeptide binding]; other site 262316005148 Phd_YefM; Region: PhdYeFM; cl09153 262316005149 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316005150 active site 262316005151 metal binding site [ion binding]; metal-binding site 262316005152 Cytochrome P450; Region: p450; cl12078 262316005153 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316005154 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316005155 active site 262316005156 ATP binding site [chemical binding]; other site 262316005157 substrate binding site [chemical binding]; other site 262316005158 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316005159 activation loop (A-loop); other site 262316005160 activation loop (A-loop); other site 262316005161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316005162 Cytochrome P450; Region: p450; cl12078 262316005163 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316005164 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316005165 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 262316005166 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316005167 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316005168 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 262316005169 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 262316005170 Active Sites [active] 262316005171 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 262316005172 putative active site [active] 262316005173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262316005174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316005175 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316005176 dimerization interface [polypeptide binding]; other site 262316005177 Ferredoxin [Energy production and conversion]; Region: COG1146 262316005178 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 262316005179 HicB family; Region: HicB; pfam05534 262316005180 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316005181 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316005182 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316005183 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 262316005184 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 262316005185 Predicted ATPase [General function prediction only]; Region: COG4637 262316005186 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316005187 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316005188 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 262316005189 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 262316005190 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 262316005191 active site residue [active] 262316005192 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 262316005193 active site residue [active] 262316005194 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316005195 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316005196 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316005197 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316005198 Cytochrome P450; Region: p450; cl12078 262316005199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316005200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316005201 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316005202 aspartate aminotransferase; Provisional; Region: PRK08361 262316005203 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316005204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316005205 homodimer interface [polypeptide binding]; other site 262316005206 catalytic residue [active] 262316005207 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 262316005208 haloalkane dehalogenase; Provisional; Region: PRK00870 262316005209 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 262316005210 active site 262316005211 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316005212 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 262316005213 dimer interface [polypeptide binding]; other site 262316005214 active site 262316005215 Predicted membrane protein [Function unknown]; Region: COG4270 262316005216 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 262316005217 dimer interface [polypeptide binding]; other site 262316005218 ligand binding site [chemical binding]; other site 262316005219 MgtE intracellular N domain; Region: MgtE_N; cl15244 262316005220 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 262316005221 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 262316005222 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316005223 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316005224 heat shock protein 90; Provisional; Region: PRK05218 262316005225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316005226 TIGR03085 family protein; Region: TIGR03085 262316005227 DinB superfamily; Region: DinB_2; cl00986 262316005228 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 262316005229 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316005230 Protein of unknown function (DUF3705); Region: DUF3705; pfam12492 262316005231 CCC1-related family of proteins; Region: CCC1_like; cl00278 262316005232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316005233 S-adenosylmethionine binding site [chemical binding]; other site 262316005234 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316005235 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316005236 regulatory phosphorylation site [posttranslational modification]; other site 262316005237 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 262316005238 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 262316005239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316005240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316005241 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 262316005242 cyclase homology domain; Region: CHD; cd07302 262316005243 nucleotidyl binding site; other site 262316005244 metal binding site [ion binding]; metal-binding site 262316005245 dimer interface [polypeptide binding]; other site 262316005246 Predicted ATPase [General function prediction only]; Region: COG3899 262316005247 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 262316005248 catalytic triad [active] 262316005249 active site nucleophile [active] 262316005250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 262316005251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316005252 putative substrate translocation pore; other site 262316005253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 262316005254 Predicted kinase [General function prediction only]; Region: COG0645 262316005255 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316005256 Active site [active] 262316005257 Domain of unknown function (DUF477); Region: DUF477; cl01535 262316005258 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316005259 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316005260 NAD(P) binding site [chemical binding]; other site 262316005261 catalytic residues [active] 262316005262 PemK-like protein; Region: PemK; cl00995 262316005263 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316005264 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 262316005265 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 262316005266 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 262316005267 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 262316005268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316005269 dimer interface [polypeptide binding]; other site 262316005270 putative PBP binding loops; other site 262316005271 ABC-ATPase subunit interface; other site 262316005272 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 262316005273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316005274 dimer interface [polypeptide binding]; other site 262316005275 conserved gate region; other site 262316005276 putative PBP binding loops; other site 262316005277 ABC-ATPase subunit interface; other site 262316005278 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316005279 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316005280 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 262316005281 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 262316005282 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 262316005283 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 262316005284 inhibitor-cofactor binding pocket; inhibition site 262316005285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316005286 catalytic residue [active] 262316005287 Amidinotransferase; Region: Amidinotransf; cl12043 262316005288 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 262316005289 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 262316005290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316005291 Cobalt transport protein; Region: CbiQ; cl00463 262316005292 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 262316005293 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 262316005294 Walker A/P-loop; other site 262316005295 ATP binding site [chemical binding]; other site 262316005296 Q-loop/lid; other site 262316005297 ABC transporter signature motif; other site 262316005298 Walker B; other site 262316005299 D-loop; other site 262316005300 H-loop/switch region; other site 262316005301 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 262316005302 Walker A/P-loop; other site 262316005303 ATP binding site [chemical binding]; other site 262316005304 Q-loop/lid; other site 262316005305 ABC transporter signature motif; other site 262316005306 Walker B; other site 262316005307 D-loop; other site 262316005308 H-loop/switch region; other site 262316005309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316005310 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 262316005311 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316005312 Walker A/P-loop; other site 262316005313 ATP binding site [chemical binding]; other site 262316005314 Q-loop/lid; other site 262316005315 ABC transporter signature motif; other site 262316005316 Walker B; other site 262316005317 D-loop; other site 262316005318 H-loop/switch region; other site 262316005319 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316005320 active site 262316005321 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 262316005322 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 262316005323 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 262316005324 [4Fe-4S] binding site [ion binding]; other site 262316005325 molybdopterin cofactor binding site; other site 262316005326 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 262316005327 molybdopterin cofactor binding site; other site 262316005328 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 262316005329 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 262316005330 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 262316005331 FAD binding pocket [chemical binding]; other site 262316005332 FAD binding motif [chemical binding]; other site 262316005333 catalytic residues [active] 262316005334 NAD binding pocket [chemical binding]; other site 262316005335 phosphate binding motif [ion binding]; other site 262316005336 beta-alpha-beta structure motif; other site 262316005337 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 262316005338 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 262316005339 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316005340 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316005341 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005342 mce related protein; Region: MCE; pfam02470 262316005343 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005344 mce related protein; Region: MCE; pfam02470 262316005345 mce related protein; Region: MCE; pfam02470 262316005346 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005347 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005348 mce related protein; Region: MCE; pfam02470 262316005349 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 262316005350 dimer interface [polypeptide binding]; other site 262316005351 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005352 mce related protein; Region: MCE; pfam02470 262316005353 mce related protein; Region: MCE; pfam02470 262316005354 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316005355 Domain of unknown function DUF140; Region: DUF140; cl00510 262316005356 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 262316005357 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 262316005358 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 262316005359 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 262316005360 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316005361 catalytic residue [active] 262316005362 TQXA domain; Region: TQXA_dom; TIGR03934 262316005363 cysteine synthases; Region: cysKM; TIGR01136 262316005364 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 262316005365 dimer interface [polypeptide binding]; other site 262316005366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316005367 catalytic residue [active] 262316005368 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 262316005369 trimer interface [polypeptide binding]; other site 262316005370 active site 262316005371 substrate binding site [chemical binding]; other site 262316005372 CoA binding site [chemical binding]; other site 262316005373 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316005374 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316005375 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 262316005376 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316005377 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 262316005378 active site 262316005379 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 262316005380 non-prolyl cis peptide bond; other site 262316005381 Muconolactone delta-isomerase; Region: MIase; cl01992 262316005382 Muconolactone delta-isomerase; Region: MIase; cl01992 262316005383 DNA primase; Validated; Region: dnaG; PRK05667 262316005384 CHC2 zinc finger; Region: zf-CHC2; cl02597 262316005385 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 262316005386 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 262316005387 active site 262316005388 metal binding site [ion binding]; metal-binding site 262316005389 interdomain interaction site; other site 262316005390 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 262316005391 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 262316005392 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 262316005393 E-class dimer interface [polypeptide binding]; other site 262316005394 P-class dimer interface [polypeptide binding]; other site 262316005395 active site 262316005396 Cu2+ binding site [ion binding]; other site 262316005397 Zn2+ binding site [ion binding]; other site 262316005398 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 262316005399 Domain of unknown function (DUF477); Region: DUF477; cl01535 262316005400 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 262316005401 PPE family; Region: PPE; pfam00823 262316005402 glycyl-tRNA synthetase; Provisional; Region: PRK04173 262316005403 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 262316005404 active site 262316005405 motif 2; other site 262316005406 motif 3; other site 262316005407 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 262316005408 anticodon binding site; other site 262316005409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262316005410 dimerization interface [polypeptide binding]; other site 262316005411 putative DNA binding site [nucleotide binding]; other site 262316005412 putative Zn2+ binding site [ion binding]; other site 262316005413 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 262316005414 metal binding site 2 [ion binding]; metal-binding site 262316005415 putative DNA binding helix; other site 262316005416 metal binding site 1 [ion binding]; metal-binding site 262316005417 dimer interface [polypeptide binding]; other site 262316005418 structural Zn2+ binding site [ion binding]; other site 262316005419 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 262316005420 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 262316005421 catalytic residue [active] 262316005422 putative FPP diphosphate binding site; other site 262316005423 putative FPP binding hydrophobic cleft; other site 262316005424 dimer interface [polypeptide binding]; other site 262316005425 putative IPP diphosphate binding site; other site 262316005426 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 262316005427 Recombination protein O N terminal; Region: RecO_N; pfam11967 262316005428 Recombination protein O C terminal; Region: RecO_C; pfam02565 262316005429 amidase; Provisional; Region: PRK06061 262316005430 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 262316005431 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 262316005432 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316005433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316005434 catalytic residue [active] 262316005435 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 262316005436 GTPase Era; Reviewed; Region: era; PRK00089 262316005437 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 262316005438 G1 box; other site 262316005439 GTP/Mg2+ binding site [chemical binding]; other site 262316005440 Switch I region; other site 262316005441 G2 box; other site 262316005442 Switch II region; other site 262316005443 G3 box; other site 262316005444 G4 box; other site 262316005445 G5 box; other site 262316005446 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 262316005447 Domain of unknown function DUF21; Region: DUF21; pfam01595 262316005448 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 262316005449 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 262316005450 Transporter associated domain; Region: CorC_HlyC; cl08393 262316005451 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316005452 Phage integrase family; Region: Phage_integrase; pfam00589 262316005453 Int/Topo IB signature motif; other site 262316005454 active site 262316005455 DNA binding site [nucleotide binding] 262316005456 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316005457 MULE transposase domain; Region: MULE; pfam10551 262316005458 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 262316005459 putative transposase OrfB; Reviewed; Region: PHA02517 262316005460 Integrase core domain; Region: rve; cl01316 262316005461 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316005462 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316005463 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 262316005464 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 262316005465 PhoH-like protein; Region: PhoH; cl12134 262316005466 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 262316005467 chaperone protein DnaJ; Provisional; Region: PRK14278 262316005468 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 262316005469 HSP70 interaction site [polypeptide binding]; other site 262316005470 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 262316005471 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 262316005472 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 262316005473 HrcA protein C terminal domain; Region: HrcA; pfam01628 262316005474 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 262316005475 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316005476 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 262316005477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316005478 MbtH-like protein; Region: MbtH; cl01279 262316005479 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 262316005480 Condensation domain; Region: Condensation; cl09290 262316005481 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316005482 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316005483 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316005484 Condensation domain; Region: Condensation; cl09290 262316005485 peptide synthase; Provisional; Region: PRK12467 262316005486 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316005487 Condensation domain; Region: Condensation; cl09290 262316005488 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316005489 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316005490 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316005491 Condensation domain; Region: Condensation; cl09290 262316005492 peptide synthase; Provisional; Region: PRK12316 262316005493 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316005494 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 262316005495 NADP binding site [chemical binding]; other site 262316005496 active site 262316005497 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316005498 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316005499 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 262316005500 active site 262316005501 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 262316005502 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316005503 Condensation domain; Region: Condensation; cl09290 262316005504 Nonribosomal peptide synthase; Region: NRPS; pfam08415 262316005505 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316005506 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316005507 malonyl-CoA synthase; Validated; Region: PRK07514 262316005508 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316005509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316005510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316005511 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316005512 Cytochrome P450; Region: p450; cl12078 262316005513 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316005514 classical (c) SDRs; Region: SDR_c; cd05233 262316005515 NAD(P) binding site [chemical binding]; other site 262316005516 active site 262316005517 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316005518 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316005519 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316005520 NAD(P) binding site [chemical binding]; other site 262316005521 catalytic residues [active] 262316005522 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 262316005523 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316005524 mce related protein; Region: MCE; pfam02470 262316005525 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316005526 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005527 mce related protein; Region: MCE; pfam02470 262316005528 Exo70 exocyst complex subunit; Region: Exo70; pfam03081 262316005529 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005530 mce related protein; Region: MCE; pfam02470 262316005531 mce related protein; Region: MCE; pfam02470 262316005532 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005533 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005534 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005535 mce related protein; Region: MCE; pfam02470 262316005536 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316005537 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316005538 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316005539 classical (c) SDRs; Region: SDR_c; cd05233 262316005540 short chain dehydrogenase; Provisional; Region: PRK05650 262316005541 NAD(P) binding site [chemical binding]; other site 262316005542 active site 262316005543 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316005544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005545 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 262316005546 DNA binding residues [nucleotide binding] 262316005547 putative dimer interface [polypeptide binding]; other site 262316005548 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 262316005549 dinuclear metal binding motif [ion binding]; other site 262316005550 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316005551 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316005552 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 262316005553 dinuclear metal binding motif [ion binding]; other site 262316005554 salicylate synthase MbtI; Reviewed; Region: PRK07912 262316005555 chorismate binding enzyme; Region: Chorismate_bind; cl10555 262316005556 Domain of unknown function (DUF897); Region: DUF897; cl01312 262316005557 coproporphyrinogen III oxidase; Validated; Region: PRK05628 262316005558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 262316005559 HemN C-terminal region; Region: HemN_C; pfam06969 262316005560 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 262316005561 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316005562 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316005563 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 262316005564 Active Sites [active] 262316005565 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296 262316005566 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 262316005567 Walker A/P-loop; other site 262316005568 ATP binding site [chemical binding]; other site 262316005569 Q-loop/lid; other site 262316005570 ABC transporter signature motif; other site 262316005571 Walker B; other site 262316005572 D-loop; other site 262316005573 H-loop/switch region; other site 262316005574 TOBE-like domain; Region: TOBE_3; pfam12857 262316005575 sulfate transport protein; Provisional; Region: cysT; CHL00187 262316005576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316005577 dimer interface [polypeptide binding]; other site 262316005578 conserved gate region; other site 262316005579 putative PBP binding loops; other site 262316005580 ABC-ATPase subunit interface; other site 262316005581 sulfate transport protein; Provisional; Region: cysT; CHL00187 262316005582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316005583 dimer interface [polypeptide binding]; other site 262316005584 conserved gate region; other site 262316005585 putative PBP binding loops; other site 262316005586 ABC-ATPase subunit interface; other site 262316005587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316005588 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 262316005589 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 262316005590 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 262316005591 GTP-binding protein LepA; Provisional; Region: PRK05433 262316005592 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 262316005593 G1 box; other site 262316005594 putative GEF interaction site [polypeptide binding]; other site 262316005595 GTP/Mg2+ binding site [chemical binding]; other site 262316005596 Switch I region; other site 262316005597 G2 box; other site 262316005598 G3 box; other site 262316005599 Switch II region; other site 262316005600 G4 box; other site 262316005601 G5 box; other site 262316005602 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 262316005603 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 262316005604 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 262316005605 PemK-like protein; Region: PemK; cl00995 262316005606 FOG: CBS domain [General function prediction only]; Region: COG0517 262316005607 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 262316005608 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316005609 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 262316005610 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 262316005611 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 262316005612 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 262316005613 Uncharacterized conserved protein [Function unknown]; Region: COG2308 262316005614 Domain of unknown function (DUF404); Region: DUF404; pfam04169 262316005615 Domain of unknown function (DUF407); Region: DUF407; pfam04174 262316005616 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 262316005617 hypothetical protein; Reviewed; Region: PRK07914 262316005618 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 262316005619 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 262316005620 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 262316005621 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 262316005622 FAD binding site [chemical binding]; other site 262316005623 substrate binding site [chemical binding]; other site 262316005624 catalytic base [active] 262316005625 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 262316005626 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316005627 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 262316005628 active site 262316005629 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316005630 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 262316005631 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316005632 active site 262316005633 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316005634 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316005635 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 262316005636 putative NADP binding site [chemical binding]; other site 262316005637 active site 262316005638 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316005639 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316005640 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 262316005641 active site 262316005642 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316005643 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316005644 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316005645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005646 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316005647 Enoylreductase; Region: PKS_ER; smart00829 262316005648 NAD(P) binding site [chemical binding]; other site 262316005649 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 262316005650 putative NADP binding site [chemical binding]; other site 262316005651 active site 262316005652 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316005653 Condensation domain; Region: Condensation; cl09290 262316005654 Transport protein; Region: actII; TIGR00833 262316005655 Protein export membrane protein; Region: SecD_SecF; cl14618 262316005656 Transport protein; Region: actII; TIGR00833 262316005657 PE-PPE domain; Region: PE-PPE; pfam08237 262316005658 acyl-CoA synthetase; Validated; Region: PRK05850 262316005659 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316005660 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316005661 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 262316005662 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316005663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005664 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316005665 Transport protein; Region: actII; TIGR00833 262316005666 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 262316005667 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316005668 catalytic core [active] 262316005669 Domain of unknown function DUF143; Region: DUF143; cl00519 262316005670 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 262316005671 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 262316005672 active site 262316005673 (T/H)XGH motif; other site 262316005674 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 262316005675 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 262316005676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316005677 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 262316005678 Walker A motif; other site 262316005679 ATP binding site [chemical binding]; other site 262316005680 Walker B motif; other site 262316005681 arginine finger; other site 262316005682 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 262316005683 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 262316005684 putative catalytic cysteine [active] 262316005685 Mechanosensitive ion channel; Region: MS_channel; pfam00924 262316005686 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 262316005687 ligand binding site [chemical binding]; other site 262316005688 flexible hinge region; other site 262316005689 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 262316005690 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 262316005691 dimerization interface [polypeptide binding]; other site 262316005692 cyclase homology domain; Region: CHD; cd07302 262316005693 nucleotidyl binding site; other site 262316005694 metal binding site [ion binding]; metal-binding site 262316005695 dimer interface [polypeptide binding]; other site 262316005696 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 262316005697 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 262316005698 substrate binding site [chemical binding]; other site 262316005699 ATP binding site [chemical binding]; other site 262316005700 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 262316005701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316005702 DNA-binding site [nucleotide binding]; DNA binding site 262316005703 UTRA domain; Region: UTRA; cl01230 262316005704 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 262316005705 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 262316005706 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 262316005707 tetramer interface [polypeptide binding]; other site 262316005708 active site 262316005709 Mg2+/Mn2+ binding site [ion binding]; other site 262316005710 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 262316005711 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 262316005712 substrate binding site [chemical binding]; other site 262316005713 ligand binding site [chemical binding]; other site 262316005714 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 262316005715 substrate binding site [chemical binding]; other site 262316005716 NAD synthetase; Reviewed; Region: nadE; PRK02628 262316005717 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 262316005718 multimer interface [polypeptide binding]; other site 262316005719 active site 262316005720 catalytic triad [active] 262316005721 protein interface 1 [polypeptide binding]; other site 262316005722 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 262316005723 homodimer interface [polypeptide binding]; other site 262316005724 NAD binding pocket [chemical binding]; other site 262316005725 ATP binding pocket [chemical binding]; other site 262316005726 Mg binding site [ion binding]; other site 262316005727 active-site loop [active] 262316005728 Isochorismatase family; Region: Isochorismatase; pfam00857 262316005729 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 262316005730 catalytic triad [active] 262316005731 conserved cis-peptide bond; other site 262316005732 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/...; Region: SIRT4; cd01409 262316005733 NAD-dependent deacetylase; Provisional; Region: PRK05333 262316005734 NAD+ binding site [chemical binding]; other site 262316005735 substrate binding site [chemical binding]; other site 262316005736 Zn binding site [ion binding]; other site 262316005737 Cytochrome P450; Region: p450; cl12078 262316005738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316005739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316005740 gamma-glutamyl kinase; Provisional; Region: PRK05429 262316005741 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 262316005742 nucleotide binding site [chemical binding]; other site 262316005743 homotetrameric interface [polypeptide binding]; other site 262316005744 putative phosphate binding site [ion binding]; other site 262316005745 putative allosteric binding site; other site 262316005746 PUA domain; Region: PUA; cl00607 262316005747 GTPase CgtA; Reviewed; Region: obgE; PRK12296 262316005748 GTP1/OBG; Region: GTP1_OBG; pfam01018 262316005749 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 262316005750 G1 box; other site 262316005751 GTP/Mg2+ binding site [chemical binding]; other site 262316005752 Switch I region; other site 262316005753 G2 box; other site 262316005754 G3 box; other site 262316005755 Switch II region; other site 262316005756 G4 box; other site 262316005757 G5 box; other site 262316005758 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 262316005759 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 262316005760 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 262316005761 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 262316005762 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 262316005763 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 262316005764 homodimer interface [polypeptide binding]; other site 262316005765 oligonucleotide binding site [chemical binding]; other site 262316005766 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 262316005767 active site 262316005768 multimer interface [polypeptide binding]; other site 262316005769 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 262316005770 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 262316005771 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316005772 active site 262316005773 HIGH motif; other site 262316005774 nucleotide binding site [chemical binding]; other site 262316005775 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 262316005776 active site 262316005777 KMSKS motif; other site 262316005778 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 262316005779 tRNA binding surface [nucleotide binding]; other site 262316005780 anticodon binding site; other site 262316005781 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 262316005782 Uncharacterized conserved protein [Function unknown]; Region: COG3268 262316005783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005784 NAD(P) binding pocket [chemical binding]; other site 262316005785 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 262316005786 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316005787 MULE transposase domain; Region: MULE; pfam10551 262316005788 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 262316005789 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 262316005790 GTP binding site [chemical binding]; other site 262316005791 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 262316005792 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 262316005793 TPP-binding site [chemical binding]; other site 262316005794 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 262316005795 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 262316005796 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 262316005797 dimer interface [polypeptide binding]; other site 262316005798 PYR/PP interface [polypeptide binding]; other site 262316005799 TPP binding site [chemical binding]; other site 262316005800 substrate binding site [chemical binding]; other site 262316005801 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 262316005802 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 262316005803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316005804 Walker A motif; other site 262316005805 ATP binding site [chemical binding]; other site 262316005806 Walker B motif; other site 262316005807 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 262316005808 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 262316005809 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 262316005810 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 262316005811 oligomer interface [polypeptide binding]; other site 262316005812 active site residues [active] 262316005813 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 262316005814 oligomer interface [polypeptide binding]; other site 262316005815 active site residues [active] 262316005816 trigger factor; Provisional; Region: tig; PRK01490 262316005817 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 262316005818 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 262316005819 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 262316005820 Beta-lactamase; Region: Beta-lactamase; cl01009 262316005821 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 262316005822 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 262316005823 putative DNA binding site [nucleotide binding]; other site 262316005824 catalytic residue [active] 262316005825 putative H2TH interface [polypeptide binding]; other site 262316005826 putative catalytic residues [active] 262316005827 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 262316005828 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262316005829 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 262316005830 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 262316005831 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 262316005832 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 262316005833 Zn binding site [ion binding]; other site 262316005834 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 262316005835 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316005836 active site 262316005837 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 262316005838 apolar tunnel; other site 262316005839 heme binding site [chemical binding]; other site 262316005840 dimerization interface [polypeptide binding]; other site 262316005841 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 262316005842 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 262316005843 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 262316005844 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316005845 Walker A/P-loop; other site 262316005846 ATP binding site [chemical binding]; other site 262316005847 Q-loop/lid; other site 262316005848 ABC transporter signature motif; other site 262316005849 Walker B; other site 262316005850 D-loop; other site 262316005851 H-loop/switch region; other site 262316005852 ABC transporter; Region: ABC_tran_2; pfam12848 262316005853 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 262316005854 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 262316005855 dimer interface [polypeptide binding]; other site 262316005856 ssDNA binding site [nucleotide binding]; other site 262316005857 tetramer (dimer of dimers) interface [polypeptide binding]; other site 262316005858 Copper resistance protein D; Region: CopD; cl00563 262316005859 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 262316005860 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 262316005861 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 262316005862 putative acyl-acceptor binding pocket; other site 262316005863 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 262316005864 putative acyl-acceptor binding pocket; other site 262316005865 Condensation domain; Region: Condensation; cl09290 262316005866 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316005867 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 262316005868 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316005869 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262316005870 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 262316005871 Integrase core domain; Region: rve; cl01316 262316005872 Cutinase; Region: Cutinase; pfam01083 262316005873 enoyl-CoA hydratase; Provisional; Region: PRK05870 262316005874 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316005875 substrate binding site [chemical binding]; other site 262316005876 oxyanion hole (OAH) forming residues; other site 262316005877 trimer interface [polypeptide binding]; other site 262316005878 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 262316005879 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 262316005880 E3 interaction surface; other site 262316005881 lipoyl attachment site [posttranslational modification]; other site 262316005882 e3 binding domain; Region: E3_binding; pfam02817 262316005883 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 262316005884 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 262316005885 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 262316005886 alpha subunit interface [polypeptide binding]; other site 262316005887 TPP binding site [chemical binding]; other site 262316005888 heterodimer interface [polypeptide binding]; other site 262316005889 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262316005890 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 262316005891 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 262316005892 tetramer interface [polypeptide binding]; other site 262316005893 TPP-binding site [chemical binding]; other site 262316005894 heterodimer interface [polypeptide binding]; other site 262316005895 phosphorylation loop region [posttranslational modification] 262316005896 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 262316005897 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 262316005898 putative active site [active] 262316005899 putative catalytic site [active] 262316005900 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316005901 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316005902 active site 262316005903 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 262316005904 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316005905 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316005906 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 262316005907 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 262316005908 carboxyltransferase (CT) interaction site; other site 262316005909 biotinylation site [posttranslational modification]; other site 262316005910 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 262316005911 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316005912 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316005913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316005914 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316005915 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 262316005916 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262316005917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005918 NAD(P) binding site [chemical binding]; other site 262316005919 active site 262316005920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005921 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 262316005922 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 262316005923 putative active site [active] 262316005924 putative substrate binding site [chemical binding]; other site 262316005925 catalytic site [active] 262316005926 dimer interface [polypeptide binding]; other site 262316005927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 262316005928 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 262316005929 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 262316005930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316005931 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 262316005932 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 262316005933 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 262316005934 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 262316005935 catalytic triad [active] 262316005936 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 262316005937 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 262316005938 active site 262316005939 metal binding site [ion binding]; metal-binding site 262316005940 dimer interface [polypeptide binding]; other site 262316005941 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 262316005942 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316005943 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 262316005944 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 262316005945 phosphate binding site [ion binding]; other site 262316005946 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 262316005947 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 262316005948 putative active site [active] 262316005949 putative catalytic site [active] 262316005950 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316005951 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316005952 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 262316005953 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 262316005954 putative NAD(P) binding site [chemical binding]; other site 262316005955 active site 262316005956 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 262316005957 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 262316005958 active site 262316005959 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 262316005960 active site 262316005961 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 262316005962 DNA binding residues [nucleotide binding] 262316005963 dimer interface [polypeptide binding]; other site 262316005964 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316005965 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316005966 [2Fe-2S] cluster binding site [ion binding]; other site 262316005967 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 262316005968 putative alpha subunit interface [polypeptide binding]; other site 262316005969 putative active site [active] 262316005970 putative substrate binding site [chemical binding]; other site 262316005971 Fe binding site [ion binding]; other site 262316005972 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 262316005973 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 262316005974 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316005975 NAD binding site [chemical binding]; other site 262316005976 catalytic residues [active] 262316005977 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 262316005978 putative active site [active] 262316005979 putative catalytic site [active] 262316005980 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 262316005981 active site 262316005982 catalytic site [active] 262316005983 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 262316005984 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316005985 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316005986 [2Fe-2S] cluster binding site [ion binding]; other site 262316005987 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 262316005988 hydrophobic ligand binding site; other site 262316005989 Cytochrome P450; Region: p450; cl12078 262316005990 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 262316005991 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 262316005992 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316005993 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316005994 Transcriptional regulators [Transcription]; Region: FadR; COG2186 262316005995 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316005996 DNA-binding site [nucleotide binding]; DNA binding site 262316005997 FCD domain; Region: FCD; cl11656 262316005998 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 262316005999 classical (c) SDRs; Region: SDR_c; cd05233 262316006000 NAD(P) binding site [chemical binding]; other site 262316006001 active site 262316006002 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316006003 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 262316006004 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316006005 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006008 active site 262316006009 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006010 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006011 active site 262316006012 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006013 active site 262316006014 AMP-binding enzyme; Region: AMP-binding; pfam00501 262316006015 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316006016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316006017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006018 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316006019 CoenzymeA binding site [chemical binding]; other site 262316006020 subunit interaction site [polypeptide binding]; other site 262316006021 PHB binding site; other site 262316006022 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316006023 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 262316006024 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 262316006025 Moco binding site; other site 262316006026 metal coordination site [ion binding]; other site 262316006027 PAS fold; Region: PAS_4; pfam08448 262316006028 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 262316006029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316006030 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006031 active site 262316006032 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006033 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316006034 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 262316006035 active site 262316006036 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316006037 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316006038 substrate binding pocket [chemical binding]; other site 262316006039 Cytochrome P450; Region: p450; cl12078 262316006040 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 262316006041 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 262316006042 NAD binding site [chemical binding]; other site 262316006043 catalytic Zn binding site [ion binding]; other site 262316006044 substrate binding site [chemical binding]; other site 262316006045 structural Zn binding site [ion binding]; other site 262316006046 Predicted membrane protein [Function unknown]; Region: COG1511 262316006047 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 262316006048 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 262316006049 ABC-2 type transporter; Region: ABC2_membrane; cl11417 262316006050 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316006051 Walker A/P-loop; other site 262316006052 ATP binding site [chemical binding]; other site 262316006053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316006054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006055 short chain dehydrogenase; Provisional; Region: PRK06197 262316006056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006057 NAD(P) binding site [chemical binding]; other site 262316006058 active site 262316006059 Cytochrome P450; Region: p450; cl12078 262316006060 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 262316006061 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316006062 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316006063 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 262316006064 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316006065 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316006066 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316006067 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316006068 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316006069 [2Fe-2S] cluster binding site [ion binding]; other site 262316006070 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 262316006071 catalytic triad [active] 262316006072 conserved cis-peptide bond; other site 262316006073 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316006074 CoenzymeA binding site [chemical binding]; other site 262316006075 subunit interaction site [polypeptide binding]; other site 262316006076 PHB binding site; other site 262316006077 acyl-CoA synthetase; Validated; Region: PRK07798 262316006078 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316006079 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316006080 classical (c) SDRs; Region: SDR_c; cd05233 262316006081 NAD(P) binding site [chemical binding]; other site 262316006082 active site 262316006083 Cytochrome P450; Region: p450; cl12078 262316006084 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316006085 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 262316006086 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316006087 active site 262316006088 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006089 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006090 active site 262316006091 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 262316006092 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006093 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006094 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316006095 acyl-CoA synthetase; Validated; Region: PRK07798 262316006096 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316006097 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316006098 enoyl-CoA hydratase; Provisional; Region: PRK06210 262316006099 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316006100 substrate binding site [chemical binding]; other site 262316006101 oxyanion hole (OAH) forming residues; other site 262316006102 trimer interface [polypeptide binding]; other site 262316006103 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 262316006104 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 262316006105 active site 262316006106 inhibitor site; inhibition site 262316006107 dimer interface [polypeptide binding]; other site 262316006108 catalytic residue [active] 262316006109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006110 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316006111 NAD(P) binding site [chemical binding]; other site 262316006112 active site 262316006113 tetracycline repressor protein TetR; Provisional; Region: PRK13756 262316006114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006115 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 262316006116 enoyl-CoA hydratase; Provisional; Region: PRK08272 262316006117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316006118 substrate binding site [chemical binding]; other site 262316006119 oxyanion hole (OAH) forming residues; other site 262316006120 trimer interface [polypeptide binding]; other site 262316006121 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316006122 CoenzymeA binding site [chemical binding]; other site 262316006123 subunit interaction site [polypeptide binding]; other site 262316006124 PHB binding site; other site 262316006125 enoyl-CoA hydratase; Provisional; Region: PRK06688 262316006126 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316006127 substrate binding site [chemical binding]; other site 262316006128 oxyanion hole (OAH) forming residues; other site 262316006129 trimer interface [polypeptide binding]; other site 262316006130 enoyl-CoA hydratase; Provisional; Region: PRK06494 262316006131 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316006132 substrate binding site [chemical binding]; other site 262316006133 oxyanion hole (OAH) forming residues; other site 262316006134 trimer interface [polypeptide binding]; other site 262316006135 enoyl-CoA hydratase; Provisional; Region: PRK05864 262316006136 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316006137 substrate binding site [chemical binding]; other site 262316006138 oxyanion hole (OAH) forming residues; other site 262316006139 trimer interface [polypeptide binding]; other site 262316006140 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 262316006141 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316006142 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 262316006143 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316006144 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316006145 AMP-binding enzyme; Region: AMP-binding; pfam00501 262316006146 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316006147 Transcriptional regulators [Transcription]; Region: GntR; COG1802 262316006148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316006149 DNA-binding site [nucleotide binding]; DNA binding site 262316006150 FCD domain; Region: FCD; cl11656 262316006151 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006152 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006153 active site 262316006154 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316006155 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 262316006156 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316006157 dimer interface [polypeptide binding]; other site 262316006158 active site 262316006159 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316006160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006161 NAD(P) binding site [chemical binding]; other site 262316006162 active site 262316006163 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006164 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006165 active site 262316006166 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316006167 classical (c) SDRs; Region: SDR_c; cd05233 262316006168 NAD(P) binding site [chemical binding]; other site 262316006169 active site 262316006170 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316006171 Phosphotransferase enzyme family; Region: APH; pfam01636 262316006172 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316006173 substrate binding site [chemical binding]; other site 262316006174 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316006175 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262316006176 Walker A/P-loop; other site 262316006177 ATP binding site [chemical binding]; other site 262316006178 Q-loop/lid; other site 262316006179 ABC transporter signature motif; other site 262316006180 Walker B; other site 262316006181 D-loop; other site 262316006182 H-loop/switch region; other site 262316006183 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 262316006184 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 262316006185 FAD binding pocket [chemical binding]; other site 262316006186 FAD binding motif [chemical binding]; other site 262316006187 phosphate binding motif [ion binding]; other site 262316006188 NAD binding pocket [chemical binding]; other site 262316006189 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262316006190 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316006191 Walker A/P-loop; other site 262316006192 ATP binding site [chemical binding]; other site 262316006193 Q-loop/lid; other site 262316006194 ABC transporter signature motif; other site 262316006195 Walker B; other site 262316006196 D-loop; other site 262316006197 H-loop/switch region; other site 262316006198 Transposase domain (DUF772); Region: DUF772; cl12084 262316006199 Glucitol operon activator protein (GutM); Region: GutM; cl01890 262316006200 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 262316006201 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 262316006202 active site 262316006203 dimerization interface [polypeptide binding]; other site 262316006204 ribonuclease PH; Reviewed; Region: rph; PRK00173 262316006205 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 262316006206 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 262316006207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316006208 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 262316006209 Rhomboid family; Region: Rhomboid; cl11446 262316006210 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 262316006211 putative active site pocket [active] 262316006212 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group...; Region: DmpA_OAT; cl00603 262316006213 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 262316006214 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 262316006215 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 262316006216 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 262316006217 active site 262316006218 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 262316006219 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316006220 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316006221 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316006222 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 262316006223 putative homodimer interface [polypeptide binding]; other site 262316006224 putative active site pocket [active] 262316006225 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 262316006226 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 262316006227 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 262316006228 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 262316006229 glycogen branching enzyme; Provisional; Region: PRK05402 262316006230 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 262316006231 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 262316006232 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 262316006233 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 262316006234 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 262316006235 putative acyltransferase; Provisional; Region: PRK05790 262316006236 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316006237 dimer interface [polypeptide binding]; other site 262316006238 active site 262316006239 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 262316006240 dimer interface [polypeptide binding]; other site 262316006241 substrate binding site [chemical binding]; other site 262316006242 metal binding site [ion binding]; metal-binding site 262316006243 Protein of unknown function DUF91; Region: DUF91; cl00709 262316006244 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 262316006245 cyclase homology domain; Region: CHD; cd07302 262316006246 nucleotidyl binding site; other site 262316006247 metal binding site [ion binding]; metal-binding site 262316006248 dimer interface [polypeptide binding]; other site 262316006249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316006250 putative substrate translocation pore; other site 262316006251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262316006252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316006253 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 262316006254 putative dimerization interface [polypeptide binding]; other site 262316006255 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 262316006256 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 262316006257 AlkA N-terminal domain; Region: AlkA_N; cl05528 262316006258 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 262316006259 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 262316006260 minor groove reading motif; other site 262316006261 helix-hairpin-helix signature motif; other site 262316006262 substrate binding pocket [chemical binding]; other site 262316006263 active site 262316006264 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316006265 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316006266 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 262316006267 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 262316006268 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 262316006269 DNA binding site [nucleotide binding] 262316006270 active site 262316006271 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316006272 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 262316006273 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 262316006274 hinge; other site 262316006275 active site 262316006276 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 262316006277 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 262316006278 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 262316006279 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 262316006280 alpha subunit interaction interface [polypeptide binding]; other site 262316006281 Walker A motif; other site 262316006282 ATP binding site [chemical binding]; other site 262316006283 Walker B motif; other site 262316006284 inhibitor binding site; inhibition site 262316006285 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 262316006286 ATP synthase; Region: ATP-synt; cl00365 262316006287 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 262316006288 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 262316006289 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 262316006290 beta subunit interaction interface [polypeptide binding]; other site 262316006291 Walker A motif; other site 262316006292 ATP binding site [chemical binding]; other site 262316006293 Walker B motif; other site 262316006294 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 262316006295 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 262316006296 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 262316006297 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 262316006298 ATP synthase subunit C; Region: ATP-synt_C; cl00466 262316006299 ATP synthase A chain; Region: ATP-synt_A; cl00413 262316006300 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 262316006301 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 262316006302 Mg++ binding site [ion binding]; other site 262316006303 putative catalytic motif [active] 262316006304 substrate binding site [chemical binding]; other site 262316006305 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 262316006306 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 262316006307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316006308 S-adenosylmethionine binding site [chemical binding]; other site 262316006309 peptide chain release factor 1; Validated; Region: prfA; PRK00591 262316006310 RF-1 domain; Region: RF-1; cl02875 262316006311 RF-1 domain; Region: RF-1; cl02875 262316006312 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 262316006313 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 262316006314 transcription termination factor Rho; Provisional; Region: PRK12608 262316006315 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 262316006316 RNA binding site [nucleotide binding]; other site 262316006317 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 262316006318 multimer interface [polypeptide binding]; other site 262316006319 Walker A motif; other site 262316006320 ATP binding site [chemical binding]; other site 262316006321 Walker B motif; other site 262316006322 homoserine kinase; Provisional; Region: PRK01212 262316006323 threonine synthase; Reviewed; Region: PRK06721 262316006324 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 262316006325 homodimer interface [polypeptide binding]; other site 262316006326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316006327 catalytic residue [active] 262316006328 homoserine dehydrogenase; Provisional; Region: PRK06349 262316006329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006330 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 262316006331 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 262316006332 diaminopimelate decarboxylase; Region: lysA; TIGR01048 262316006333 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 262316006334 active site 262316006335 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 262316006336 substrate binding site [chemical binding]; other site 262316006337 catalytic residues [active] 262316006338 dimer interface [polypeptide binding]; other site 262316006339 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 262316006340 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 262316006341 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 262316006342 active site 262316006343 HIGH motif; other site 262316006344 KMSK motif region; other site 262316006345 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 262316006346 tRNA binding surface [nucleotide binding]; other site 262316006347 anticodon binding site; other site 262316006348 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316006349 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316006350 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 262316006351 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 262316006352 dimer interface [polypeptide binding]; other site 262316006353 ADP-ribose binding site [chemical binding]; other site 262316006354 active site 262316006355 nudix motif; other site 262316006356 metal binding site [ion binding]; metal-binding site 262316006357 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316006358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006359 Ion channel; Region: Ion_trans_2; cl11596 262316006360 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 262316006361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006362 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 262316006363 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316006364 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 262316006365 metal binding site [ion binding]; metal-binding site 262316006366 Rrf2 family protein; Region: rrf2_super; TIGR00738 262316006367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316006368 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 262316006369 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 262316006370 G1 box; other site 262316006371 putative GEF interaction site [polypeptide binding]; other site 262316006372 GTP/Mg2+ binding site [chemical binding]; other site 262316006373 Switch I region; other site 262316006374 G2 box; other site 262316006375 CysD dimerization site [polypeptide binding]; other site 262316006376 G3 box; other site 262316006377 Switch II region; other site 262316006378 G4 box; other site 262316006379 G5 box; other site 262316006380 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 262316006381 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 262316006382 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 262316006383 ligand-binding site [chemical binding]; other site 262316006384 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 262316006385 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 262316006386 Active Sites [active] 262316006387 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316006388 CoenzymeA binding site [chemical binding]; other site 262316006389 subunit interaction site [polypeptide binding]; other site 262316006390 PHB binding site; other site 262316006391 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 262316006392 active site clefts [active] 262316006393 zinc binding site [ion binding]; other site 262316006394 dimer interface [polypeptide binding]; other site 262316006395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316006396 dimer interface [polypeptide binding]; other site 262316006397 conserved gate region; other site 262316006398 putative PBP binding loops; other site 262316006399 ABC-ATPase subunit interface; other site 262316006400 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 262316006401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316006402 dimer interface [polypeptide binding]; other site 262316006403 conserved gate region; other site 262316006404 putative PBP binding loops; other site 262316006405 ABC-ATPase subunit interface; other site 262316006406 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 262316006407 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 262316006408 Walker A/P-loop; other site 262316006409 ATP binding site [chemical binding]; other site 262316006410 Q-loop/lid; other site 262316006411 ABC transporter signature motif; other site 262316006412 Walker B; other site 262316006413 D-loop; other site 262316006414 H-loop/switch region; other site 262316006415 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 262316006416 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 262316006417 Walker A/P-loop; other site 262316006418 ATP binding site [chemical binding]; other site 262316006419 Q-loop/lid; other site 262316006420 ABC transporter signature motif; other site 262316006421 Walker B; other site 262316006422 D-loop; other site 262316006423 H-loop/switch region; other site 262316006424 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 262316006425 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 262316006426 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 262316006427 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316006428 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316006429 Mnd1 family; Region: Mnd1; pfam03962 262316006430 Uncharacterized conserved protein [Function unknown]; Region: COG4717 262316006431 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 262316006432 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 262316006433 active site 262316006434 metal binding site [ion binding]; metal-binding site 262316006435 DNA binding site [nucleotide binding] 262316006436 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316006437 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316006438 active site 262316006439 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316006440 catalytic core [active] 262316006441 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 262316006442 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 262316006443 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262316006444 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 262316006445 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316006446 Walker A/P-loop; other site 262316006447 ATP binding site [chemical binding]; other site 262316006448 Q-loop/lid; other site 262316006449 ABC transporter signature motif; other site 262316006450 Walker B; other site 262316006451 D-loop; other site 262316006452 H-loop/switch region; other site 262316006453 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 262316006454 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 262316006455 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 262316006456 Walker A/P-loop; other site 262316006457 ATP binding site [chemical binding]; other site 262316006458 Q-loop/lid; other site 262316006459 ABC transporter signature motif; other site 262316006460 Walker B; other site 262316006461 D-loop; other site 262316006462 H-loop/switch region; other site 262316006463 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316006464 Transposase domain (DUF772); Region: DUF772; cl12084 262316006465 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 262316006466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316006467 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316006468 phosphopeptide binding site; other site 262316006469 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316006470 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316006471 active site 262316006472 ATP binding site [chemical binding]; other site 262316006473 substrate binding site [chemical binding]; other site 262316006474 activation loop (A-loop); other site 262316006475 cyclase homology domain; Region: CHD; cd07302 262316006476 nucleotidyl binding site; other site 262316006477 metal binding site [ion binding]; metal-binding site 262316006478 dimer interface [polypeptide binding]; other site 262316006479 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 262316006480 putative active site [active] 262316006481 amidase; Provisional; Region: PRK12470 262316006482 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 262316006483 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 262316006484 HIT family signature motif; other site 262316006485 catalytic residue [active] 262316006486 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262316006487 metal binding site [ion binding]; metal-binding site 262316006488 active site 262316006489 I-site; other site 262316006490 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262316006491 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316006492 hypothetical protein; Validated; Region: PRK05868 262316006493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006494 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 262316006495 Fe-S cluster binding site [ion binding]; other site 262316006496 DNA binding site [nucleotide binding] 262316006497 active site 262316006498 H+ Antiporter protein; Region: 2A0121; TIGR00900 262316006499 FAD binding domain; Region: FAD_binding_4; pfam01565 262316006500 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 262316006501 Cytochrome P450; Region: p450; cl12078 262316006502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316006503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006504 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316006505 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 262316006506 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 262316006507 ATP binding site [chemical binding]; other site 262316006508 Mg++ binding site [ion binding]; other site 262316006509 motif III; other site 262316006510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316006511 nucleotide binding region [chemical binding]; other site 262316006512 ATP-binding site [chemical binding]; other site 262316006513 DbpA RNA binding domain; Region: DbpA; pfam03880 262316006514 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316006515 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316006516 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 262316006517 Cytochrome P450; Region: p450; cl12078 262316006518 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316006519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006520 NAD(P) binding site [chemical binding]; other site 262316006521 active site 262316006522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316006523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006524 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316006525 classical (c) SDRs; Region: SDR_c; cd05233 262316006526 NAD(P) binding site [chemical binding]; other site 262316006527 active site 262316006528 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316006529 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316006530 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316006531 classical (c) SDRs; Region: SDR_c; cd05233 262316006532 NAD(P) binding site [chemical binding]; other site 262316006533 active site 262316006534 Cytochrome P450; Region: p450; cl12078 262316006535 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 262316006536 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 262316006537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316006538 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262316006539 putative substrate translocation pore; other site 262316006540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316006541 putative substrate translocation pore; other site 262316006542 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 262316006543 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 262316006544 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 262316006545 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 262316006546 TPP-binding site [chemical binding]; other site 262316006547 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 262316006548 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262316006549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006550 NAD(P) binding site [chemical binding]; other site 262316006551 active site 262316006552 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262316006553 classical (c) SDRs; Region: SDR_c; cd05233 262316006554 NAD(P) binding site [chemical binding]; other site 262316006555 active site 262316006556 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 262316006557 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 262316006558 Malic enzyme, N-terminal domain; Region: malic; pfam00390 262316006559 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 262316006560 putative NAD(P) binding site [chemical binding]; other site 262316006561 malate dehydrogenase; Provisional; Region: PRK05442 262316006562 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 262316006563 NAD(P) binding site [chemical binding]; other site 262316006564 dimer interface [polypeptide binding]; other site 262316006565 malate binding site [chemical binding]; other site 262316006566 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 262316006567 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 262316006568 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 262316006569 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 262316006570 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 262316006571 Walker A/P-loop; other site 262316006572 ATP binding site [chemical binding]; other site 262316006573 Q-loop/lid; other site 262316006574 ABC transporter signature motif; other site 262316006575 Walker B; other site 262316006576 D-loop; other site 262316006577 H-loop/switch region; other site 262316006578 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 262316006579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316006580 dimer interface [polypeptide binding]; other site 262316006581 conserved gate region; other site 262316006582 ABC-ATPase subunit interface; other site 262316006583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 262316006584 dimer interface [polypeptide binding]; other site 262316006585 conserved gate region; other site 262316006586 putative PBP binding loops; other site 262316006587 ABC-ATPase subunit interface; other site 262316006588 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316006589 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 262316006590 MgtE intracellular N domain; Region: MgtE_N; cl15244 262316006591 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 262316006592 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 262316006593 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 262316006594 N-acetyl-D-glucosamine binding site [chemical binding]; other site 262316006595 Domain of unknown function DUF59; Region: DUF59; cl00941 262316006596 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 262316006597 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 262316006598 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 262316006599 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 262316006600 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 262316006601 protein binding site [polypeptide binding]; other site 262316006602 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 262316006603 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316006604 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 262316006605 DNA binding residues [nucleotide binding] 262316006606 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 262316006607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316006608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316006609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006610 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316006611 Q-loop/lid; other site 262316006612 ABC transporter signature motif; other site 262316006613 Walker B; other site 262316006614 ATP-binding ABC transporter family nodulation protein NodI; Region: nodI; TIGR01288 262316006615 D-loop; other site 262316006616 H-loop/switch region; other site 262316006617 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 262316006618 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 262316006619 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 262316006620 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 262316006621 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 262316006622 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 262316006623 ligand binding site [chemical binding]; other site 262316006624 oligomer interface [polypeptide binding]; other site 262316006625 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 262316006626 dimer interface [polypeptide binding]; other site 262316006627 N-terminal domain interface [polypeptide binding]; other site 262316006628 sulfate 1 binding site; other site 262316006629 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 262316006630 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316006631 Transposase domain (DUF772); Region: DUF772; cl12084 262316006632 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 262316006633 DivIVA domain; Region: DivI1A_domain; TIGR03544 262316006634 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316006635 active site 262316006636 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 262316006637 dihydropteroate synthase; Region: DHPS; TIGR01496 262316006638 substrate binding pocket [chemical binding]; other site 262316006639 dimer interface [polypeptide binding]; other site 262316006640 inhibitor binding site; inhibition site 262316006641 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 262316006642 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316006643 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 262316006644 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 262316006645 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 262316006646 metal binding site [ion binding]; metal-binding site 262316006647 putative dimer interface [polypeptide binding]; other site 262316006648 PPE family; Region: PPE; pfam00823 262316006649 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316006650 PE family; Region: PE; pfam00934 262316006651 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316006652 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316006653 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316006654 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 262316006655 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 262316006656 putative trimer interface [polypeptide binding]; other site 262316006657 putative CoA binding site [chemical binding]; other site 262316006658 metabolite-proton symporter; Region: 2A0106; TIGR00883 262316006659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316006660 putative substrate translocation pore; other site 262316006661 acyl-CoA synthetase; Validated; Region: PRK07787 262316006662 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316006663 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316006664 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316006665 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316006666 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316006667 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316006668 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 262316006669 NAD binding site [chemical binding]; other site 262316006670 catalytic residues [active] 262316006671 Cytochrome P450; Region: p450; cl12078 262316006672 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006673 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006674 active site 262316006675 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 262316006676 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 262316006677 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316006678 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006679 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316006680 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 262316006681 active site 262316006682 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 262316006683 putative active site [active] 262316006684 putative catalytic site [active] 262316006685 lipid-transfer protein; Provisional; Region: PRK07855 262316006686 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316006687 active site 262316006688 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316006689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006690 Proline dehydrogenase; Region: Pro_dh; cl03282 262316006691 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316006692 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316006693 NAD(P) binding site [chemical binding]; other site 262316006694 catalytic residues [active] 262316006695 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 262316006696 PPE family; Region: PPE; pfam00823 262316006697 acyl-CoA synthetase; Validated; Region: PRK05850 262316006698 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316006699 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 262316006700 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 262316006701 ATP-sulfurylase; Region: ATPS; cd00517 262316006702 active site 262316006703 HXXH motif; other site 262316006704 flexible loop; other site 262316006705 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 262316006706 ligand-binding site [chemical binding]; other site 262316006707 PPE family; Region: PPE; pfam00823 262316006708 PPE family; Region: PPE; pfam00823 262316006709 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316006710 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316006711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006712 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316006713 Enoylreductase; Region: PKS_ER; smart00829 262316006714 NAD(P) binding site [chemical binding]; other site 262316006715 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 262316006716 putative NADP binding site [chemical binding]; other site 262316006717 active site 262316006718 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316006719 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316006720 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 262316006721 active site 262316006722 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316006723 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 262316006724 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 262316006725 generic binding surface II; other site 262316006726 ssDNA binding site; other site 262316006727 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 262316006728 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316006729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316006730 homodimer interface [polypeptide binding]; other site 262316006731 catalytic residue [active] 262316006732 Ferredoxin [Energy production and conversion]; Region: COG1146 262316006733 4Fe-4S binding domain; Region: Fer4; cl02805 262316006734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 262316006735 Integrase core domain; Region: rve; cl01316 262316006736 FO synthase; Reviewed; Region: fbiC; PRK09234 262316006737 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 262316006738 FeS/SAM binding site; other site 262316006739 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 262316006740 FeS/SAM binding site; other site 262316006741 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 262316006742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316006743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006744 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 262316006745 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 262316006746 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 262316006747 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 262316006748 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 262316006749 G1 box; other site 262316006750 putative GEF interaction site [polypeptide binding]; other site 262316006751 GTP/Mg2+ binding site [chemical binding]; other site 262316006752 Switch I region; other site 262316006753 G2 box; other site 262316006754 G3 box; other site 262316006755 Switch II region; other site 262316006756 G4 box; other site 262316006757 G5 box; other site 262316006758 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 262316006759 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 262316006760 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 262316006761 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 262316006762 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 262316006763 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 262316006764 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_Nitrate-R-NarG-like; cd02750 262316006765 [4Fe-4S] binding site [ion binding]; other site 262316006766 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 262316006767 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 262316006768 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 262316006769 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 262316006770 molybdopterin cofactor binding site; other site 262316006771 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 262316006772 active site 262316006773 8-oxo-dGMP binding site [chemical binding]; other site 262316006774 nudix motif; other site 262316006775 metal binding site [ion binding]; metal-binding site 262316006776 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 262316006777 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 262316006778 aromatic arch; other site 262316006779 DCoH dimer interaction site [polypeptide binding]; other site 262316006780 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 262316006781 DCoH tetramer interaction site [polypeptide binding]; other site 262316006782 substrate binding site [chemical binding]; other site 262316006783 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 262316006784 uncharacterized HhH-GPD family protein; Region: TIGR03252 262316006785 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 262316006786 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316006787 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 262316006788 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316006789 DNA-binding site [nucleotide binding]; DNA binding site 262316006790 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412 262316006791 NAD+ binding site [chemical binding]; other site 262316006792 substrate binding site [chemical binding]; other site 262316006793 Zn binding site [ion binding]; other site 262316006794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316006795 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 262316006796 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 262316006797 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 262316006798 NAD binding site [chemical binding]; other site 262316006799 homotetramer interface [polypeptide binding]; other site 262316006800 homodimer interface [polypeptide binding]; other site 262316006801 active site 262316006802 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316006803 enoyl-CoA hydratase; Provisional; Region: PRK06688 262316006804 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316006805 substrate binding site [chemical binding]; other site 262316006806 oxyanion hole (OAH) forming residues; other site 262316006807 trimer interface [polypeptide binding]; other site 262316006808 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 262316006809 dTDP-glucose 4,6-dehydratase; Region: PLN02166 262316006810 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 262316006811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006812 NAD(P) binding site [chemical binding]; other site 262316006813 active site 262316006814 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 262316006815 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 262316006816 malonyl-CoA binding site [chemical binding]; other site 262316006817 dimer interface [polypeptide binding]; other site 262316006818 active site 262316006819 product binding site; other site 262316006820 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 262316006821 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 262316006822 enoyl-CoA hydratase; Provisional; Region: PRK08252 262316006823 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316006824 substrate binding site [chemical binding]; other site 262316006825 oxyanion hole (OAH) forming residues; other site 262316006826 trimer interface [polypeptide binding]; other site 262316006827 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 262316006828 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316006829 dimer interface [polypeptide binding]; other site 262316006830 active site 262316006831 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316006832 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316006833 NAD(P) binding site [chemical binding]; other site 262316006834 catalytic residues [active] 262316006835 Cytochrome P450; Region: p450; cl12078 262316006836 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 262316006837 short chain dehydrogenase; Provisional; Region: PRK05693 262316006838 NADP binding site [chemical binding]; other site 262316006839 active site 262316006840 steroid binding site; other site 262316006841 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 262316006842 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 262316006843 ligand binding site [chemical binding]; other site 262316006844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316006845 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 262316006846 Walker A motif; other site 262316006847 ATP binding site [chemical binding]; other site 262316006848 Walker B motif; other site 262316006849 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 262316006850 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 262316006851 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 262316006852 metal ion-dependent adhesion site (MIDAS); other site 262316006853 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 262316006854 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006855 active site 262316006856 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006857 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006858 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 262316006859 FMN binding site [chemical binding]; other site 262316006860 dimer interface [polypeptide binding]; other site 262316006861 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 262316006862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316006863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006864 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 262316006865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006866 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 262316006867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006868 NAD(P) binding site [chemical binding]; other site 262316006869 active site 262316006870 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 262316006871 NAD(P) binding site [chemical binding]; other site 262316006872 putative active site [active] 262316006873 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 262316006874 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 262316006875 THF binding site; other site 262316006876 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 262316006877 substrate binding site [chemical binding]; other site 262316006878 THF binding site; other site 262316006879 zinc-binding site [ion binding]; other site 262316006880 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 262316006881 DoxX; Region: DoxX; cl00976 262316006882 pyruvate phosphate dikinase; Provisional; Region: PRK05878 262316006883 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 262316006884 FeoC like transcriptional regulator; Region: FeoC; cl07573 262316006885 short chain dehydrogenase; Validated; Region: PRK05855 262316006886 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 262316006887 dimer interface [polypeptide binding]; other site 262316006888 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316006889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006890 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 262316006891 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 262316006892 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 262316006893 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 262316006894 cyclase homology domain; Region: CHD; cd07302 262316006895 nucleotidyl binding site; other site 262316006896 metal binding site [ion binding]; metal-binding site 262316006897 dimer interface [polypeptide binding]; other site 262316006898 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 262316006899 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 262316006900 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316006901 active site 262316006902 metal binding site [ion binding]; metal-binding site 262316006903 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316006904 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316006905 active site 262316006906 GTP-binding protein YchF; Reviewed; Region: PRK09601 262316006907 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 262316006908 G1 box; other site 262316006909 GTP/Mg2+ binding site [chemical binding]; other site 262316006910 Switch I region; other site 262316006911 G2 box; other site 262316006912 Switch II region; other site 262316006913 G3 box; other site 262316006914 G4 box; other site 262316006915 G5 box; other site 262316006916 GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information on the function of the TGS domain, but...; Region: TGS; cl03735 262316006917 LytB protein; Region: LYTB; cl00507 262316006918 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 262316006919 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 262316006920 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 262316006921 generic binding surface II; other site 262316006922 generic binding surface I; other site 262316006923 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 262316006924 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 262316006925 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 262316006926 putative NAD(P) binding site [chemical binding]; other site 262316006927 active site 262316006928 putative substrate binding site [chemical binding]; other site 262316006929 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 262316006930 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316006931 substrate binding pocket [chemical binding]; other site 262316006932 catalytic triad [active] 262316006933 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 262316006934 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 262316006935 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 262316006936 putative active site [active] 262316006937 fumarate hydratase; Reviewed; Region: fumC; PRK00485 262316006938 Class II fumarases; Region: Fumarase_classII; cd01362 262316006939 active site 262316006940 tetramer interface [polypeptide binding]; other site 262316006941 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 262316006942 cyclase homology domain; Region: CHD; cd07302 262316006943 nucleotidyl binding site; other site 262316006944 metal binding site [ion binding]; metal-binding site 262316006945 dimer interface [polypeptide binding]; other site 262316006946 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 262316006947 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 262316006948 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 262316006949 putative active site [active] 262316006950 PhoH-like protein; Region: PhoH; cl12134 262316006951 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 262316006952 dinuclear metal binding motif [ion binding]; other site 262316006953 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 262316006954 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 262316006955 dimer interface [polypeptide binding]; other site 262316006956 glycine-pyridoxal phosphate binding site [chemical binding]; other site 262316006957 active site 262316006958 folate binding site [chemical binding]; other site 262316006959 pantothenate kinase; Provisional; Region: PRK05439 262316006960 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 262316006961 ATP-binding site [chemical binding]; other site 262316006962 CoA-binding site [chemical binding]; other site 262316006963 Mg2+-binding site [ion binding]; other site 262316006964 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 262316006965 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 262316006966 catalytic residue [active] 262316006967 putative FPP diphosphate binding site; other site 262316006968 putative FPP binding hydrophobic cleft; other site 262316006969 dimer interface [polypeptide binding]; other site 262316006970 putative IPP diphosphate binding site; other site 262316006971 Haemolysin-III related; Region: HlyIII; cl03831 262316006972 ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon...; Region: ketosteroid_isomerase; cd00781 262316006973 dimer interface [polypeptide binding]; other site 262316006974 active site/substrate binding site [active] 262316006975 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 262316006976 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955 262316006977 catalytic residues [active] 262316006978 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 262316006979 conserved cys residue [active] 262316006980 acyl-CoA thioesterase II; Region: tesB; TIGR00189 262316006981 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 262316006982 active site 262316006983 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 262316006984 catalytic triad [active] 262316006985 dimer interface [polypeptide binding]; other site 262316006986 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 262316006987 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 262316006988 active site 262316006989 multimer interface [polypeptide binding]; other site 262316006990 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 262316006991 nudix motif; other site 262316006992 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316006993 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316006994 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 262316006995 putative acyl-acceptor binding pocket; other site 262316006996 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 262316006997 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 262316006998 nucleotide binding site/active site [active] 262316006999 HIT family signature motif; other site 262316007000 catalytic residue [active] 262316007001 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 262316007002 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 262316007003 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 262316007004 active site 262316007005 dimer interface [polypeptide binding]; other site 262316007006 motif 1; other site 262316007007 motif 2; other site 262316007008 motif 3; other site 262316007009 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 262316007010 anticodon binding site; other site 262316007011 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 262316007012 M28, and M42; Region: Zinc_peptidase_like; cl14876 262316007013 metal binding site [ion binding]; metal-binding site 262316007014 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316007015 CoenzymeA binding site [chemical binding]; other site 262316007016 subunit interaction site [polypeptide binding]; other site 262316007017 PHB binding site; other site 262316007018 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 262316007019 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 262316007020 active site 262316007021 catalytic tetrad [active] 262316007022 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 262316007023 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 262316007024 FMN binding site [chemical binding]; other site 262316007025 substrate binding site [chemical binding]; other site 262316007026 putative catalytic residue [active] 262316007027 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 262316007028 Cupin domain; Region: Cupin_2; cl09118 262316007029 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316007030 Predicted transcriptional regulator [Transcription]; Region: COG2345 262316007031 Ferredoxin [Energy production and conversion]; Region: COG1146 262316007032 4Fe-4S binding domain; Region: Fer4; cl02805 262316007033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316007034 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 262316007035 tetramer interface [polypeptide binding]; other site 262316007036 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 262316007037 heterodimer interface [polypeptide binding]; other site 262316007038 active site 262316007039 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 262316007040 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 262316007041 Active site [active] 262316007042 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 262316007043 iron-sulfur cluster [ion binding]; other site 262316007044 [2Fe-2S] cluster binding site [ion binding]; other site 262316007045 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316007046 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 262316007047 alpha subunit interaction site [polypeptide binding]; other site 262316007048 beta subunit interaction site [polypeptide binding]; other site 262316007049 iron-sulfur cluster [ion binding]; other site 262316007050 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 262316007051 beta subunit interface [polypeptide binding]; other site 262316007052 alpha subunit interface [polypeptide binding]; other site 262316007053 active site 262316007054 substrate binding site [chemical binding]; other site 262316007055 Fe binding site [ion binding]; other site 262316007056 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 262316007057 inter-subunit interface; other site 262316007058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007059 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316007060 NAD(P) binding site [chemical binding]; other site 262316007061 active site 262316007062 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 262316007063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316007064 Transcriptional regulator [Transcription]; Region: IclR; COG1414 262316007065 Bacterial transcriptional regulator; Region: IclR; pfam01614 262316007066 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 262316007067 active site 262316007068 catalytic triad [active] 262316007069 oxyanion hole [active] 262316007070 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 262316007071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316007072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007073 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316007074 anti sigma factor interaction site; other site 262316007075 regulatory phosphorylation site [posttranslational modification]; other site 262316007076 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 262316007077 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 262316007078 putative heme binding pocket [chemical binding]; other site 262316007079 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316007080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007081 NAD(P) binding site [chemical binding]; other site 262316007082 active site 262316007083 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 262316007084 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316007085 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316007086 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316007087 substrate binding site [chemical binding]; other site 262316007088 oxyanion hole (OAH) forming residues; other site 262316007089 trimer interface [polypeptide binding]; other site 262316007090 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 262316007091 hydrophobic ligand binding site; other site 262316007092 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 262316007093 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316007094 DNA binding site [nucleotide binding] 262316007095 Int/Topo IB signature motif; other site 262316007096 active site 262316007097 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 262316007098 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 262316007099 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 262316007100 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 262316007101 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 262316007102 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 262316007103 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316007104 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316007105 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316007106 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 262316007107 hypothetical protein; Provisional; Region: PRK06194 262316007108 classical (c) SDRs; Region: SDR_c; cd05233 262316007109 NAD(P) binding site [chemical binding]; other site 262316007110 active site 262316007111 Transcriptional regulator [Transcription]; Region: IclR; COG1414 262316007112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316007113 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316007114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316007115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007116 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316007117 classical (c) SDRs; Region: SDR_c; cd05233 262316007118 NAD(P) binding site [chemical binding]; other site 262316007119 active site 262316007120 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316007121 classical (c) SDRs; Region: SDR_c; cd05233 262316007122 NAD(P) binding site [chemical binding]; other site 262316007123 active site 262316007124 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316007125 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316007126 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316007127 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316007128 NAD(P) binding site [chemical binding]; other site 262316007129 catalytic residues [active] 262316007130 Cation efflux family; Region: Cation_efflux; cl00316 262316007131 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316007132 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316007133 Clp protease ATP binding subunit; Region: clpC; CHL00095 262316007134 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 262316007135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316007136 Coenzyme A binding pocket [chemical binding]; other site 262316007137 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 262316007138 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 262316007139 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316007140 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 262316007141 SelR domain; Region: SelR; cl00369 262316007142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316007143 S-adenosylmethionine binding site [chemical binding]; other site 262316007144 Chlorite dismutase; Region: Chlor_dismutase; cl01280 262316007145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007146 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 262316007147 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 262316007148 substrate binding site [chemical binding]; other site 262316007149 active site 262316007150 enoyl-CoA hydratase; Provisional; Region: PRK07327 262316007151 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316007152 substrate binding site [chemical binding]; other site 262316007153 oxyanion hole (OAH) forming residues; other site 262316007154 trimer interface [polypeptide binding]; other site 262316007155 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 262316007156 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 262316007157 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 262316007158 putative active site [active] 262316007159 catalytic site [active] 262316007160 putative substrate binding site [chemical binding]; other site 262316007161 HRDC domain; Region: HRDC; cl02578 262316007162 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 262316007163 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 262316007164 TPP-binding site; other site 262316007165 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 262316007166 PYR/PP interface [polypeptide binding]; other site 262316007167 dimer interface [polypeptide binding]; other site 262316007168 TPP binding site [chemical binding]; other site 262316007169 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262316007170 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 262316007171 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 262316007172 Citrate transporter; Region: CitMHS; pfam03600 262316007173 transmembrane helices; other site 262316007174 TRAM domain; Region: TRAM; cl01282 262316007175 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 262316007176 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 262316007177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007178 potassium/proton antiporter; Reviewed; Region: PRK05326 262316007179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007180 potassium/proton antiporter; Reviewed; Region: PRK05326 262316007181 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 262316007182 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 262316007183 generic binding surface II; other site 262316007184 ssDNA binding site; other site 262316007185 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 262316007186 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 262316007187 trimer interface [polypeptide binding]; other site 262316007188 active site 262316007189 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 262316007190 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 262316007191 active site 262316007192 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 262316007193 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 262316007194 RNA polymerase sigma factor; Provisional; Region: PRK05901 262316007195 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316007196 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 262316007197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 262316007198 DNA binding residues [nucleotide binding] 262316007199 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 262316007200 homotrimer interaction site [polypeptide binding]; other site 262316007201 putative active site [active] 262316007202 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 262316007203 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 262316007204 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 262316007205 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 262316007206 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 262316007207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316007208 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 262316007209 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 262316007210 DNA binding residues [nucleotide binding] 262316007211 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 262316007212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007214 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262316007215 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 262316007216 PAC2 family; Region: PAC2; cl00847 262316007217 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316007218 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316007219 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 262316007220 heme-binding site [chemical binding]; other site 262316007221 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 262316007222 ATP cone domain; Region: ATP-cone; pfam03477 262316007223 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 262316007224 LexA repressor; Validated; Region: PRK00215 262316007225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316007226 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 262316007227 Catalytic site [active] 262316007228 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 262316007229 LGFP repeat; Region: LGFP; pfam08310 262316007230 LGFP repeat; Region: LGFP; pfam08310 262316007231 LGFP repeat; Region: LGFP; pfam08310 262316007232 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 262316007233 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316007234 active site 262316007235 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 262316007236 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 262316007237 G1 box; other site 262316007238 GTP/Mg2+ binding site [chemical binding]; other site 262316007239 Switch I region; other site 262316007240 G2 box; other site 262316007241 G3 box; other site 262316007242 Switch II region; other site 262316007243 G4 box; other site 262316007244 G5 box; other site 262316007245 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 262316007246 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 262316007247 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 262316007248 IPP transferase; Region: IPPT; cl00403 262316007249 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 262316007250 active site 262316007251 metal binding site [ion binding]; metal-binding site 262316007252 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 262316007253 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 262316007254 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 262316007255 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 262316007256 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 262316007257 FeS/SAM binding site; other site 262316007258 RecX family; Region: RecX; cl00936 262316007259 recombinase A; Provisional; Region: recA; PRK09354 262316007260 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 262316007261 hexamer interface [polypeptide binding]; other site 262316007262 Walker A motif; other site 262316007263 ATP binding site [chemical binding]; other site 262316007264 Walker B motif; other site 262316007265 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 262316007266 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 262316007267 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 262316007268 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 262316007269 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 262316007270 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316007271 PspA/IM30 family; Region: PspA_IM30; pfam04012 262316007272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316007273 non-specific DNA binding site [nucleotide binding]; other site 262316007274 salt bridge; other site 262316007275 sequence-specific DNA binding site [nucleotide binding]; other site 262316007276 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 262316007277 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 262316007278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316007279 Coenzyme A binding pocket [chemical binding]; other site 262316007280 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316007281 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 262316007282 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 262316007283 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316007284 classical (c) SDRs; Region: SDR_c; cd05233 262316007285 NAD(P) binding site [chemical binding]; other site 262316007286 active site 262316007287 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316007288 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 262316007289 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316007290 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 262316007291 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 262316007292 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 262316007293 dimer interface [polypeptide binding]; other site 262316007294 active site 262316007295 catalytic residue [active] 262316007296 Thymidylate synthase complementing protein; Region: Thy1; cl03630 262316007297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 262316007298 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 262316007299 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 262316007300 folate binding site [chemical binding]; other site 262316007301 NADP+ binding site [chemical binding]; other site 262316007302 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 262316007303 dimerization interface [polypeptide binding]; other site 262316007304 active site 262316007305 Dienelactone hydrolase family; Region: DLH; pfam01738 262316007306 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316007307 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 262316007308 homodimer interface [polypeptide binding]; other site 262316007309 active site 262316007310 TDP-binding site; other site 262316007311 acceptor substrate-binding pocket; other site 262316007312 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 262316007313 classical (c) SDRs; Region: SDR_c; cd05233 262316007314 NAD(P) binding site [chemical binding]; other site 262316007315 active site 262316007316 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 262316007317 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316007318 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316007319 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 262316007320 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 262316007321 carboxyltransferase (CT) interaction site; other site 262316007322 biotinylation site [posttranslational modification]; other site 262316007323 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 262316007324 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316007325 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316007326 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 262316007327 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316007328 Protein of unknown function (DUF3705); Region: DUF3705; pfam12492 262316007329 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316007330 CoenzymeA binding site [chemical binding]; other site 262316007331 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 262316007332 dihydrodipicolinate reductase; Provisional; Region: PRK00048 262316007333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007334 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 262316007335 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316007336 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316007337 active site 262316007338 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316007339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007340 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 262316007341 iron-sulfur cluster [ion binding]; other site 262316007342 [2Fe-2S] cluster binding site [ion binding]; other site 262316007343 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 262316007344 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 262316007345 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 262316007346 FMN-binding pocket [chemical binding]; other site 262316007347 flavin binding motif; other site 262316007348 phosphate binding motif [ion binding]; other site 262316007349 beta-alpha-beta structure motif; other site 262316007350 NAD binding pocket [chemical binding]; other site 262316007351 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316007352 catalytic loop [active] 262316007353 iron binding site [ion binding]; other site 262316007354 short chain dehydrogenase; Validated; Region: PRK05855 262316007355 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316007356 classical (c) SDRs; Region: SDR_c; cd05233 262316007357 NAD(P) binding site [chemical binding]; other site 262316007358 active site 262316007359 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 262316007360 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 262316007361 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316007362 hydrophobic ligand binding site; other site 262316007363 alanine dehydrogenase; Region: alaDH; TIGR00518 262316007364 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 262316007365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007366 Nitronate monooxygenase; Region: NMO; pfam03060 262316007367 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 262316007368 FMN binding site [chemical binding]; other site 262316007369 substrate binding site [chemical binding]; other site 262316007370 putative catalytic residue [active] 262316007371 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 262316007372 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 262316007373 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 262316007374 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 262316007375 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 262316007376 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 262316007377 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 262316007378 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 262316007379 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 262316007380 putative nucleic acid binding region [nucleotide binding]; other site 262316007381 G-X-X-G motif; other site 262316007382 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 262316007383 RNA binding site [nucleotide binding]; other site 262316007384 domain interface; other site 262316007385 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 262316007386 16S/18S rRNA binding site [nucleotide binding]; other site 262316007387 S13e-L30e interaction site [polypeptide binding]; other site 262316007388 25S rRNA binding site [nucleotide binding]; other site 262316007389 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 262316007390 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 262316007391 active site 262316007392 Riboflavin kinase; Region: Flavokinase; cl03312 262316007393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316007394 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 262316007395 FeoA domain; Region: FeoA; cl00838 262316007396 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316007397 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316007398 active site 262316007399 lipid-transfer protein; Provisional; Region: PRK08256 262316007400 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316007401 active site 262316007402 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 262316007403 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 262316007404 RNA binding site [nucleotide binding]; other site 262316007405 active site 262316007406 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 262316007407 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 262316007408 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 262316007409 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 262316007410 active site 262316007411 metal binding site [ion binding]; metal-binding site 262316007412 Predicted acyl esterases [General function prediction only]; Region: COG2936 262316007413 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 262316007414 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 262316007415 enoyl-CoA hydratase; Provisional; Region: PRK06190 262316007416 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316007417 substrate binding site [chemical binding]; other site 262316007418 oxyanion hole (OAH) forming residues; other site 262316007419 trimer interface [polypeptide binding]; other site 262316007420 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 262316007421 DHH family; Region: DHH; pfam01368 262316007422 Ribosome-binding factor A; Region: RBFA; cl00542 262316007423 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 262316007424 translation initiation factor IF-2; Region: IF-2; TIGR00487 262316007425 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 262316007426 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 262316007427 G1 box; other site 262316007428 putative GEF interaction site [polypeptide binding]; other site 262316007429 GTP/Mg2+ binding site [chemical binding]; other site 262316007430 Switch I region; other site 262316007431 G2 box; other site 262316007432 G3 box; other site 262316007433 Switch II region; other site 262316007434 G4 box; other site 262316007435 G5 box; other site 262316007436 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 262316007437 Translation-initiation factor 2; Region: IF-2; pfam11987 262316007438 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 262316007439 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 262316007440 putative RNA binding cleft [nucleotide binding]; other site 262316007441 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 262316007442 NusA N-terminal domain; Region: NusA_N; pfam08529 262316007443 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 262316007444 RNA binding site [nucleotide binding]; other site 262316007445 homodimer interface [polypeptide binding]; other site 262316007446 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 262316007447 G-X-X-G motif; other site 262316007448 ribosome maturation protein RimP; Reviewed; Region: PRK00092 262316007449 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 262316007450 Sm1 motif; other site 262316007451 D3 - B interaction site; other site 262316007452 D1 - D2 interaction site; other site 262316007453 Hfq - Hfq interaction site; other site 262316007454 RNA binding pocket [nucleotide binding]; other site 262316007455 Sm2 motif; other site 262316007456 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 262316007457 dinuclear metal binding motif [ion binding]; other site 262316007458 prolyl-tRNA synthetase; Provisional; Region: PRK09194 262316007459 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 262316007460 dimer interface [polypeptide binding]; other site 262316007461 motif 1; other site 262316007462 active site 262316007463 motif 2; other site 262316007464 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 262316007465 putative deacylase active site [active] 262316007466 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262316007467 active site 262316007468 motif 3; other site 262316007469 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 262316007470 anticodon binding site; other site 262316007471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316007472 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 262316007473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316007474 putative substrate translocation pore; other site 262316007475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316007476 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 262316007477 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 262316007478 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 262316007479 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 262316007480 catalytic triad [active] 262316007481 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 262316007482 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 262316007483 Walker A motif; other site 262316007484 homodimer interface [polypeptide binding]; other site 262316007485 ATP binding site [chemical binding]; other site 262316007486 hydroxycobalamin binding site [chemical binding]; other site 262316007487 Walker B motif; other site 262316007488 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316007489 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 262316007490 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase...; Region: vWA_Magnesium_chelatase; cd01451 262316007491 metal ion-dependent adhesion site (MIDAS); other site 262316007492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316007493 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 262316007494 Predicted dehydrogenase [General function prediction only]; Region: COG0579 262316007495 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 262316007496 mycothione reductase; Reviewed; Region: PRK07846 262316007497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007498 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262316007499 High-affinity nickel-transport protein; Region: NicO; cl00964 262316007500 Sulfatase; Region: Sulfatase; cl10460 262316007501 PPE family; Region: PPE; pfam00823 262316007502 classical (c) SDRs; Region: SDR_c; cd05233 262316007503 NAD(P) binding site [chemical binding]; other site 262316007504 active site 262316007505 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 262316007506 NAD(P) binding site [chemical binding]; other site 262316007507 catalytic residues [active] 262316007508 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 262316007509 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 262316007510 catalytic triad [active] 262316007511 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 262316007512 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 262316007513 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 262316007514 cobyric acid synthase; Provisional; Region: PRK00784 262316007515 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 262316007516 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 262316007517 catalytic triad [active] 262316007518 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 262316007519 methionine aminopeptidase; Reviewed; Region: PRK07281 262316007520 active site 262316007521 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 262316007522 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 262316007523 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 262316007524 Predicted acetyltransferase [General function prediction only]; Region: COG3393 262316007525 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 262316007526 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 262316007527 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 262316007528 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 262316007529 active site 262316007530 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 262316007531 protein binding site [polypeptide binding]; other site 262316007532 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 262316007533 putative substrate binding region [chemical binding]; other site 262316007534 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 262316007535 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 262316007536 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 262316007537 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 262316007538 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif...; Region: TlpA_like_ScsD_MtbDsbE; cd03011 262316007539 catalytic residues [active] 262316007540 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 262316007541 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 262316007542 FeS/SAM binding site; other site 262316007543 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 262316007544 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 262316007545 hinge region; other site 262316007546 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 262316007547 putative nucleotide binding site [chemical binding]; other site 262316007548 uridine monophosphate binding site [chemical binding]; other site 262316007549 homohexameric interface [polypeptide binding]; other site 262316007550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 262316007551 DNA binding site [nucleotide binding] 262316007552 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 262316007553 putative acyl-acceptor binding pocket; other site 262316007554 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 262316007555 short chain dehydrogenase; Provisional; Region: PRK06701 262316007556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007557 NAD(P) binding site [chemical binding]; other site 262316007558 active site 262316007559 ChaB; Region: ChaB; cl01887 262316007560 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 262316007561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316007562 amidase; Provisional; Region: PRK07869 262316007563 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 262316007564 elongation factor Ts; Provisional; Region: tsf; PRK09377 262316007565 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 262316007566 Elongation factor TS; Region: EF_TS; pfam00889 262316007567 Elongation factor TS; Region: EF_TS; pfam00889 262316007568 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 262316007569 rRNA interaction site [nucleotide binding]; other site 262316007570 S8 interaction site; other site 262316007571 putative laminin-1 binding site; other site 262316007572 Peptidase family M23; Region: Peptidase_M23; pfam01551 262316007573 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 262316007574 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316007575 DNA binding site [nucleotide binding] 262316007576 Int/Topo IB signature motif; other site 262316007577 active site 262316007578 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 262316007579 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 262316007580 putative active site [active] 262316007581 putative substrate binding site [chemical binding]; other site 262316007582 putative FMN binding site [chemical binding]; other site 262316007583 putative catalytic residues [active] 262316007584 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 262316007585 FAD binding pocket [chemical binding]; other site 262316007586 FAD binding motif [chemical binding]; other site 262316007587 phosphate binding motif [ion binding]; other site 262316007588 NAD binding pocket [chemical binding]; other site 262316007589 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 262316007590 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 262316007591 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 262316007592 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316007593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 262316007594 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316007595 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 262316007596 DNA binding site [nucleotide binding] 262316007597 Int/Topo IB signature motif; other site 262316007598 active site 262316007599 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 262316007600 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 262316007601 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 262316007602 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316007603 putative NAD(P) binding site [chemical binding]; other site 262316007604 active site 262316007605 putative substrate binding site [chemical binding]; other site 262316007606 ANTAR domain; Region: ANTAR; cl04297 262316007607 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 262316007608 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 262316007609 RNA/DNA hybrid binding site [nucleotide binding]; other site 262316007610 active site 262316007611 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 262316007612 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 262316007613 Catalytic site [active] 262316007614 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 262316007615 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 262316007616 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 262316007617 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 262316007618 RimM N-terminal domain; Region: RimM; pfam01782 262316007619 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 262316007620 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 262316007621 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 262316007622 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316007623 Beta-lactamase; Region: Beta-lactamase; cl01009 262316007624 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 262316007625 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316007626 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007627 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 262316007628 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316007629 active site 262316007630 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316007631 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 262316007632 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316007633 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 262316007634 active site 262316007635 signal recognition particle protein; Provisional; Region: PRK10867 262316007636 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 262316007637 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 262316007638 P loop; other site 262316007639 GTP binding site [chemical binding]; other site 262316007640 Signal peptide binding domain; Region: SRP_SPB; pfam02978 262316007641 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316007642 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316007643 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 262316007644 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316007645 ATP binding site [chemical binding]; other site 262316007646 putative Mg++ binding site [ion binding]; other site 262316007647 PII uridylyl-transferase; Provisional; Region: PRK03381 262316007648 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 262316007649 metal binding triad; other site 262316007650 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 262316007651 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 262316007652 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 262316007653 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 262316007654 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 262316007655 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 262316007656 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 262316007657 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 262316007658 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 262316007659 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 262316007660 Walker A/P-loop; other site 262316007661 ATP binding site [chemical binding]; other site 262316007662 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 262316007663 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 262316007664 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 262316007665 ABC transporter signature motif; other site 262316007666 Walker B; other site 262316007667 D-loop; other site 262316007668 H-loop/switch region; other site 262316007669 Acylphosphatase; Region: Acylphosphatase; cl00551 262316007670 OsmC-like protein; Region: OsmC; cl00767 262316007671 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 262316007672 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 262316007673 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 262316007674 DNA binding site [nucleotide binding] 262316007675 catalytic residue [active] 262316007676 H2TH interface [polypeptide binding]; other site 262316007677 putative catalytic residues [active] 262316007678 turnover-facilitating residue; other site 262316007679 intercalation triad [nucleotide binding]; other site 262316007680 8OG recognition residue [nucleotide binding]; other site 262316007681 putative reading head residues; other site 262316007682 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 262316007683 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262316007684 ribonuclease III; Reviewed; Region: rnc; PRK00102 262316007685 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 262316007686 dimerization interface [polypeptide binding]; other site 262316007687 active site 262316007688 metal binding site [ion binding]; metal-binding site 262316007689 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 262316007690 dsRNA binding site [nucleotide binding]; other site 262316007691 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 262316007692 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 262316007693 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 262316007694 Predicted permease; Region: DUF318; cl00487 262316007695 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 262316007696 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316007697 PYR/PP interface [polypeptide binding]; other site 262316007698 dimer interface [polypeptide binding]; other site 262316007699 TPP binding site [chemical binding]; other site 262316007700 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316007701 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002 262316007702 TPP-binding site [chemical binding]; other site 262316007703 dimer interface [polypeptide binding]; other site 262316007704 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316007705 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316007706 active site 262316007707 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 262316007708 active site 262316007709 (T/H)XGH motif; other site 262316007710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316007711 Vitamin K epoxide reductase family; Region: VKOR; cl01729 262316007712 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 262316007713 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316007714 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316007715 substrate binding pocket [chemical binding]; other site 262316007716 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 262316007717 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262316007718 active site 262316007719 catalytic tetrad [active] 262316007720 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 262316007721 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 262316007722 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 262316007723 ssDNA binding site; other site 262316007724 generic binding surface II; other site 262316007725 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316007726 ATP binding site [chemical binding]; other site 262316007727 putative Mg++ binding site [ion binding]; other site 262316007728 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316007729 nucleotide binding region [chemical binding]; other site 262316007730 ATP-binding site [chemical binding]; other site 262316007731 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 262316007732 DAK2 domain; Region: Dak2; cl03685 262316007733 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 262316007734 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316007735 classical (c) SDRs; Region: SDR_c; cd05233 262316007736 NAD(P) binding site [chemical binding]; other site 262316007737 active site 262316007738 short chain dehydrogenase; Provisional; Region: PRK06197 262316007739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007740 NAD(P) binding site [chemical binding]; other site 262316007741 active site 262316007742 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262316007743 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 262316007744 NADP binding site [chemical binding]; other site 262316007745 active site 262316007746 steroid binding site; other site 262316007747 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 262316007748 ligand binding site [chemical binding]; other site 262316007749 active site 262316007750 UGI interface [polypeptide binding]; other site 262316007751 catalytic site [active] 262316007752 thiamine monophosphate kinase; Provisional; Region: PRK05731 262316007753 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 262316007754 ATP binding site [chemical binding]; other site 262316007755 dimerization interface [polypeptide binding]; other site 262316007756 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 262316007757 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 262316007758 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 262316007759 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316007760 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 262316007761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007762 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 262316007763 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316007764 polyphosphate kinase; Provisional; Region: PRK05443 262316007765 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 262316007766 putative domain interface [polypeptide binding]; other site 262316007767 putative active site [active] 262316007768 catalytic site [active] 262316007769 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 262316007770 putative domain interface [polypeptide binding]; other site 262316007771 putative active site [active] 262316007772 catalytic site [active] 262316007773 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 262316007774 active site 262316007775 Ap6A binding site [chemical binding]; other site 262316007776 nudix motif; other site 262316007777 metal binding site [ion binding]; metal-binding site 262316007778 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316007779 catalytic core [active] 262316007780 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 262316007781 IHF - DNA interface [nucleotide binding]; other site 262316007782 IHF dimer interface [polypeptide binding]; other site 262316007783 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 262316007784 substrate binding site [chemical binding]; other site 262316007785 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 262316007786 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 262316007787 substrate binding site [chemical binding]; other site 262316007788 ligand binding site [chemical binding]; other site 262316007789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316007790 Transcriptional regulator [Transcription]; Region: IclR; COG1414 262316007791 Bacterial transcriptional regulator; Region: IclR; pfam01614 262316007792 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316007793 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 262316007794 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316007795 active site 262316007796 HIGH motif; other site 262316007797 nucleotide binding site [chemical binding]; other site 262316007798 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 262316007799 active site 262316007800 KMSKS motif; other site 262316007801 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 262316007802 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 262316007803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316007804 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262316007805 putative substrate translocation pore; other site 262316007806 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 262316007807 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 262316007808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007809 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 262316007810 putative L-serine binding site [chemical binding]; other site 262316007811 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 262316007812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007813 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 262316007814 ketol-acid reductoisomerase; Provisional; Region: PRK05479 262316007815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007816 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 262316007817 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 262316007818 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 262316007819 putative valine binding site [chemical binding]; other site 262316007820 dimer interface [polypeptide binding]; other site 262316007821 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 262316007822 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 262316007823 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316007824 PYR/PP interface [polypeptide binding]; other site 262316007825 dimer interface [polypeptide binding]; other site 262316007826 TPP binding site [chemical binding]; other site 262316007827 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316007828 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 262316007829 TPP-binding site [chemical binding]; other site 262316007830 dimer interface [polypeptide binding]; other site 262316007831 DoxX; Region: DoxX; cl00976 262316007832 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 262316007833 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 262316007834 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 262316007835 GatB domain; Region: GatB_Yqey; cl11497 262316007836 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 262316007837 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 262316007838 6-phosphofructokinase; Provisional; Region: PRK03202 262316007839 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 262316007840 active site 262316007841 ADP/pyrophosphate binding site [chemical binding]; other site 262316007842 dimerization interface [polypeptide binding]; other site 262316007843 allosteric effector site; other site 262316007844 fructose-1,6-bisphosphate binding site; other site 262316007845 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 262316007846 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 262316007847 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 262316007848 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 262316007849 Transport protein; Region: actII; TIGR00833 262316007850 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316007851 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316007852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316007853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007854 cystathionine gamma-lyase; Validated; Region: PRK07582 262316007855 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316007856 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316007857 catalytic residue [active] 262316007858 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step...; Region: CIMS_like; cd03310 262316007859 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 262316007860 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 262316007861 Ligand Binding Site [chemical binding]; other site 262316007862 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316007863 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 262316007864 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316007865 catalytic residue [active] 262316007866 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316007867 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 262316007868 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 262316007869 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 262316007870 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 262316007871 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 262316007872 Ligand binding site [chemical binding]; other site 262316007873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316007874 S-adenosylmethionine binding site [chemical binding]; other site 262316007875 Uncharacterized conserved protein [Function unknown]; Region: COG1543 262316007876 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 262316007877 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316007878 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316007879 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 262316007880 hydrophobic ligand binding site; other site 262316007881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007882 TIGR01777 family protein; Region: yfcH 262316007883 NAD(P) binding site [chemical binding]; other site 262316007884 active site 262316007885 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316007886 anti sigma factor interaction site; other site 262316007887 regulatory phosphorylation site [posttranslational modification]; other site 262316007888 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 262316007889 substrate binding pocket [chemical binding]; other site 262316007890 chain length determination region; other site 262316007891 substrate-Mg2+ binding site; other site 262316007892 catalytic residues [active] 262316007893 aspartate-rich region 1; other site 262316007894 active site lid residues [active] 262316007895 aspartate-rich region 2; other site 262316007896 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 262316007897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007898 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 262316007899 catalytic residues [active] 262316007900 substrate binding pocket [chemical binding]; other site 262316007901 aspartate-rich region 2; other site 262316007902 substrate-Mg2+ binding site; other site 262316007903 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 262316007904 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 262316007905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316007906 Uncharacterized conserved protein [Function unknown]; Region: COG3349 262316007907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007908 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 262316007909 iron-sulfur cluster [ion binding]; other site 262316007910 [2Fe-2S] cluster binding site [ion binding]; other site 262316007911 Transcriptional regulators [Transcription]; Region: MarR; COG1846 262316007912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316007913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 262316007914 Integrase core domain; Region: rve; cl01316 262316007915 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 262316007916 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811 262316007917 homotetramer interface [polypeptide binding]; other site 262316007918 FMN binding site [chemical binding]; other site 262316007919 homodimer contacts [polypeptide binding]; other site 262316007920 putative active site [active] 262316007921 putative substrate binding site [chemical binding]; other site 262316007922 Transport protein; Region: actII; TIGR00833 262316007923 Transport protein; Region: actII; TIGR00833 262316007924 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 262316007925 DNA photolyase; Region: DNA_photolyase; pfam00875 262316007926 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 262316007927 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 262316007928 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 262316007929 trimer interface [polypeptide binding]; other site 262316007930 active site 262316007931 substrate binding site [chemical binding]; other site 262316007932 CoA binding site [chemical binding]; other site 262316007933 FOG: WD40-like repeat [Function unknown]; Region: COG1520 262316007934 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 262316007935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316007936 S-adenosylmethionine binding site [chemical binding]; other site 262316007937 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316007938 enoyl-CoA hydratase; Provisional; Region: PRK06190 262316007939 substrate binding site [chemical binding]; other site 262316007940 oxyanion hole (OAH) forming residues; other site 262316007941 trimer interface [polypeptide binding]; other site 262316007942 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 262316007943 nudix motif; other site 262316007944 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 262316007945 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316007946 Walker A/P-loop; other site 262316007947 ATP binding site [chemical binding]; other site 262316007948 Q-loop/lid; other site 262316007949 ABC transporter signature motif; other site 262316007950 Walker B; other site 262316007951 D-loop; other site 262316007952 H-loop/switch region; other site 262316007953 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 262316007954 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 262316007955 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 262316007956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 262316007957 motif II; other site 262316007958 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 262316007959 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 262316007960 D-pathway; other site 262316007961 Putative ubiquinol binding site [chemical binding]; other site 262316007962 Low-spin heme (heme b) binding site [chemical binding]; other site 262316007963 Putative water exit pathway; other site 262316007964 Binuclear center (heme o3/CuB) [ion binding]; other site 262316007965 K-pathway; other site 262316007966 Putative proton exit pathway; other site 262316007967 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 262316007968 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 262316007969 siderophore binding site; other site 262316007970 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 262316007971 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 262316007972 putative NAD(P) binding site [chemical binding]; other site 262316007973 putative substrate binding site [chemical binding]; other site 262316007974 catalytic Zn binding site [ion binding]; other site 262316007975 structural Zn binding site [ion binding]; other site 262316007976 dimer interface [polypeptide binding]; other site 262316007977 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 262316007978 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 262316007979 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 262316007980 dimer interface [polypeptide binding]; other site 262316007981 putative radical transfer pathway; other site 262316007982 diiron center [ion binding]; other site 262316007983 tyrosyl radical; other site 262316007984 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 262316007985 putative hydrophobic ligand binding site [chemical binding]; other site 262316007986 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007987 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316007988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007989 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 262316007990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007991 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 262316007992 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 262316007993 Class I ribonucleotide reductase; Region: RNR_I; cd01679 262316007994 active site 262316007995 dimer interface [polypeptide binding]; other site 262316007996 catalytic residues [active] 262316007997 effector binding site; other site 262316007998 R2 peptide binding site; other site 262316007999 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 262316008000 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 262316008001 catalytic residues [active] 262316008002 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 262316008003 DNA polymerase IV; Validated; Region: PRK03352 262316008004 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 262316008005 active site 262316008006 DNA binding site [nucleotide binding] 262316008007 short chain dehydrogenase; Provisional; Region: PRK05650 262316008008 classical (c) SDRs; Region: SDR_c; cd05233 262316008009 NAD(P) binding site [chemical binding]; other site 262316008010 active site 262316008011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008013 Cytochrome P450; Region: p450; cl12078 262316008014 2-isopropylmalate synthase; Validated; Region: PRK03739 262316008015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316008016 Transcriptional regulators [Transcription]; Region: FadR; COG2186 262316008017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316008018 DNA-binding site [nucleotide binding]; DNA binding site 262316008019 FCD domain; Region: FCD; cl11656 262316008020 FCD domain; Region: FCD; cl11656 262316008021 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316008022 active site 262316008023 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316008024 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316008025 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316008026 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316008027 active site 262316008028 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316008029 active site 262316008030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008031 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 262316008032 NAD(P) binding site [chemical binding]; other site 262316008033 active site 262316008034 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 262316008035 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 262316008036 active site 262316008037 DNA binding site [nucleotide binding] 262316008038 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 262316008039 DNA binding site [nucleotide binding] 262316008040 Carbon starvation protein CstA; Region: CstA; cl00856 262316008041 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 262316008042 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316008043 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 262316008044 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316008045 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316008046 substrate binding site [chemical binding]; other site 262316008047 oxyanion hole (OAH) forming residues; other site 262316008048 trimer interface [polypeptide binding]; other site 262316008049 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316008050 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316008051 active site 262316008052 MspA; Region: MspA; pfam09203 262316008053 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 262316008054 putative active site [active] 262316008055 ATP binding site [chemical binding]; other site 262316008056 putative substrate binding site [chemical binding]; other site 262316008057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008058 NAD(P) binding site [chemical binding]; other site 262316008059 active site 262316008060 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316008061 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 262316008062 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316008063 Transport protein; Region: actII; TIGR00833 262316008064 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 262316008065 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 262316008066 Walker A/P-loop; other site 262316008067 ATP binding site [chemical binding]; other site 262316008068 Q-loop/lid; other site 262316008069 ABC transporter signature motif; other site 262316008070 Walker B; other site 262316008071 D-loop; other site 262316008072 H-loop/switch region; other site 262316008073 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262316008074 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 262316008075 Walker A/P-loop; other site 262316008076 ATP binding site [chemical binding]; other site 262316008077 Q-loop/lid; other site 262316008078 ABC transporter signature motif; other site 262316008079 Walker B; other site 262316008080 D-loop; other site 262316008081 H-loop/switch region; other site 262316008082 Cobalt transport protein; Region: CbiQ; cl00463 262316008083 enolase; Provisional; Region: eno; PRK00077 262316008084 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 262316008085 dimer interface [polypeptide binding]; other site 262316008086 metal binding site [ion binding]; metal-binding site 262316008087 substrate binding pocket [chemical binding]; other site 262316008088 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316008089 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316008090 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 262316008091 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 262316008092 substrate binding pocket [chemical binding]; other site 262316008093 active site 262316008094 iron coordination sites [ion binding]; other site 262316008095 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316008096 [2Fe-2S] cluster binding site [ion binding]; other site 262316008097 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 262316008098 alpha subunit interface [polypeptide binding]; other site 262316008099 active site 262316008100 substrate binding site [chemical binding]; other site 262316008101 Fe binding site [ion binding]; other site 262316008102 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316008103 classical (c) SDRs; Region: SDR_c; cd05233 262316008104 NAD(P) binding site [chemical binding]; other site 262316008105 active site 262316008106 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 262316008107 phosphate binding motif [ion binding]; other site 262316008108 beta-alpha-beta structure motif; other site 262316008109 NAD binding pocket [chemical binding]; other site 262316008110 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316008111 catalytic loop [active] 262316008112 iron binding site [ion binding]; other site 262316008113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316008114 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316008115 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 262316008116 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 262316008117 active site 262316008118 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316008119 [2Fe-2S] cluster binding site [ion binding]; other site 262316008120 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 262316008121 alpha subunit interface [polypeptide binding]; other site 262316008122 active site 262316008123 substrate binding site [chemical binding]; other site 262316008124 Fe binding site [ion binding]; other site 262316008125 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316008126 NAD(P) binding site [chemical binding]; other site 262316008127 catalytic residues [active] 262316008128 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316008129 Fic/DOC family; Region: Fic; cl00960 262316008130 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 262316008131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316008132 putative substrate translocation pore; other site 262316008133 phosphoglucomutase; Validated; Region: PRK07564 262316008134 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 262316008135 active site 262316008136 substrate binding site [chemical binding]; other site 262316008137 metal binding site [ion binding]; metal-binding site 262316008138 CrcB-like protein; Region: CRCB; cl09114 262316008139 CrcB-like protein; Region: CRCB; cl09114 262316008140 Siderophore biosynthesis protein domain; Region: AlcB; cl11000 262316008141 Protein of unknown function, DUF488; Region: DUF488; cl01246 262316008142 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 262316008143 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 262316008144 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 262316008145 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 262316008146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008147 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 262316008148 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316008149 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 262316008150 phospholipase D alpha; Region: PLN02270 262316008151 putative active site [active] 262316008152 catalytic site [active] 262316008153 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 262316008154 putative active site [active] 262316008155 catalytic site [active] 262316008156 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 262316008157 Beta-lactamase; Region: Beta-lactamase; cl01009 262316008158 Beta-lactamase; Region: Beta-lactamase; cl01009 262316008159 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 262316008160 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 262316008161 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 262316008162 homodimer interface [polypeptide binding]; other site 262316008163 active site 262316008164 TDP-binding site; other site 262316008165 acceptor substrate-binding pocket; other site 262316008166 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 262316008167 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 262316008168 DinB superfamily; Region: DinB_2; cl00986 262316008169 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 262316008170 SmpB-tmRNA interface; other site 262316008171 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 262316008172 FtsX-like permease family; Region: FtsX; pfam02687 262316008173 Type II (General) Secretory Pathway (IISP) Family protein; Region: 3a0501s02; TIGR00960 262316008174 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316008175 Walker A/P-loop; other site 262316008176 ATP binding site [chemical binding]; other site 262316008177 Q-loop/lid; other site 262316008178 ABC transporter signature motif; other site 262316008179 Walker B; other site 262316008180 D-loop; other site 262316008181 H-loop/switch region; other site 262316008182 Mechanosensitive ion channel; Region: MS_channel; pfam00924 262316008183 peptide chain release factor 2; Validated; Region: prfB; PRK00578 262316008184 RF-1 domain; Region: RF-1; cl02875 262316008185 RF-1 domain; Region: RF-1; cl02875 262316008186 ferredoxin-NADP+ reductase; Region: PLN02852 262316008187 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316008188 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 262316008189 heme-binding site [chemical binding]; other site 262316008190 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 262316008191 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 262316008192 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 262316008193 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 262316008194 PPE family; Region: PPE; pfam00823 262316008195 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316008196 PPE family; Region: PPE; pfam00823 262316008197 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316008198 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 262316008199 active site 262316008200 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316008201 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316008202 active site 262316008203 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316008204 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316008205 active site 262316008206 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 262316008207 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 262316008208 NAD(P) binding site [chemical binding]; other site 262316008209 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 262316008210 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316008211 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 262316008212 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316008213 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 262316008214 active site 262316008215 catalytic residues [active] 262316008216 metal binding site [ion binding]; metal-binding site 262316008217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008219 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316008220 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316008221 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 262316008222 active site 262316008223 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 262316008224 putative active site [active] 262316008225 ATP binding site [chemical binding]; other site 262316008226 putative substrate binding site [chemical binding]; other site 262316008227 YceI-like domain; Region: YceI; cl01001 262316008228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 262316008229 active site 262316008230 phosphorylation site [posttranslational modification] 262316008231 intermolecular recognition site; other site 262316008232 dimerization interface [polypeptide binding]; other site 262316008233 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 262316008234 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 262316008235 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 262316008236 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 262316008237 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 262316008238 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 262316008239 putative dimer interface [polypeptide binding]; other site 262316008240 [2Fe-2S] cluster binding site [ion binding]; other site 262316008241 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 262316008242 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 262316008243 SLBB domain; Region: SLBB; pfam10531 262316008244 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 262316008245 NADH dehydrogenase subunit G; Validated; Region: PRK07860 262316008246 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316008247 catalytic loop [active] 262316008248 iron binding site [ion binding]; other site 262316008249 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 262316008250 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 262316008251 [4Fe-4S] binding site [ion binding]; other site 262316008252 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 262316008253 NADH dehydrogenase; Region: NADHdh; cl00469 262316008254 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 262316008255 4Fe-4S binding domain; Region: Fer4; cl02805 262316008256 4Fe-4S binding domain; Region: Fer4; cl02805 262316008257 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 262316008258 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 262316008259 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 262316008260 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 262316008261 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 262316008262 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 262316008263 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 262316008264 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 262316008265 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 262316008266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008268 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316008269 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 262316008270 Protein of unknown function DUF58; Region: DUF58; pfam01882 262316008271 MoxR-like ATPases [General function prediction only]; Region: COG0714 262316008272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316008273 Walker A motif; other site 262316008274 ATP binding site [chemical binding]; other site 262316008275 Walker B motif; other site 262316008276 arginine finger; other site 262316008277 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316008278 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316008279 active site 262316008280 classical (c) SDRs; Region: SDR_c; cd05233 262316008281 NAD(P) binding site [chemical binding]; other site 262316008282 active site 262316008283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008285 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 262316008286 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 262316008287 putative active site [active] 262316008288 putative substrate binding site [chemical binding]; other site 262316008289 ATP binding site [chemical binding]; other site 262316008290 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 262316008291 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 262316008292 active site 262316008293 non-prolyl cis peptide bond; other site 262316008294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316008295 metabolite-proton symporter; Region: 2A0106; TIGR00883 262316008296 putative substrate translocation pore; other site 262316008297 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 262316008298 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316008299 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316008300 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316008301 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 262316008302 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 262316008303 CheB methylesterase; Region: CheB_methylest; pfam01339 262316008304 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 262316008305 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 262316008306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316008307 PAS fold; Region: PAS; pfam00989 262316008308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262316008309 putative active site [active] 262316008310 heme pocket [chemical binding]; other site 262316008311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 262316008312 PAS fold; Region: PAS; pfam00989 262316008313 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316008314 anti sigma factor interaction site; other site 262316008315 regulatory phosphorylation site [posttranslational modification]; other site 262316008316 CheB methylesterase; Region: CheB_methylest; pfam01339 262316008317 hydroperoxidase II; Provisional; Region: katE; PRK11249 262316008318 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 262316008319 tetramer interface [polypeptide binding]; other site 262316008320 heme binding pocket [chemical binding]; other site 262316008321 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 262316008322 domain interactions; other site 262316008323 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316008324 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 262316008325 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 262316008326 putative metal binding site [ion binding]; other site 262316008327 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 262316008328 putative metal binding site [ion binding]; other site 262316008329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008330 NAD(P) binding site [chemical binding]; other site 262316008331 active site 262316008332 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316008333 DNA binding site [nucleotide binding] 262316008334 Int/Topo IB signature motif; other site 262316008335 active site 262316008336 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316008337 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 262316008338 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316008339 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 262316008340 putative ADP-binding pocket [chemical binding]; other site 262316008341 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316008342 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316008343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008344 NAD(P) binding site [chemical binding]; other site 262316008345 active site 262316008346 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 262316008347 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 262316008348 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316008349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 262316008350 active site 262316008351 motif I; other site 262316008352 motif II; other site 262316008353 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 262316008354 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 262316008355 putative active site [active] 262316008356 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 262316008357 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 262316008358 substrate binding site [chemical binding]; other site 262316008359 ATP binding site [chemical binding]; other site 262316008360 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316008361 active site 262316008362 nucleotide binding site [chemical binding]; other site 262316008363 HIGH motif; other site 262316008364 KMSKS motif; other site 262316008365 classical (c) SDRs; Region: SDR_c; cd05233 262316008366 NAD(P) binding site [chemical binding]; other site 262316008367 active site 262316008368 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 262316008369 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262316008370 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 262316008371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008372 thiamine pyrophosphate protein; Provisional; Region: PRK08273 262316008373 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 262316008374 PYR/PP interface [polypeptide binding]; other site 262316008375 tetramer interface [polypeptide binding]; other site 262316008376 dimer interface [polypeptide binding]; other site 262316008377 TPP binding site [chemical binding]; other site 262316008378 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316008379 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 262316008380 TPP-binding site [chemical binding]; other site 262316008381 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 262316008382 Fe-S cluster binding site [ion binding]; other site 262316008383 active site 262316008384 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 262316008385 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 262316008386 active site 262316008387 catalytic tetrad [active] 262316008388 classical (c) SDRs; Region: SDR_c; cd05233 262316008389 NAD(P) binding site [chemical binding]; other site 262316008390 active site 262316008391 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 262316008392 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 262316008393 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 262316008394 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 262316008395 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262316008396 NAD binding site [chemical binding]; other site 262316008397 catalytic Zn binding site [ion binding]; other site 262316008398 structural Zn binding site [ion binding]; other site 262316008399 GAF domain; Region: GAF; cl00853 262316008400 ANTAR domain; Region: ANTAR; cl04297 262316008401 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 262316008402 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 262316008403 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 262316008404 DNA binding residues [nucleotide binding] 262316008405 putative dimer interface [polypeptide binding]; other site 262316008406 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 262316008407 putative dimer interface [polypeptide binding]; other site 262316008408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262316008409 PAS fold; Region: PAS_3; pfam08447 262316008410 putative active site [active] 262316008411 heme pocket [chemical binding]; other site 262316008412 ANTAR domain; Region: ANTAR; cl04297 262316008413 GAF domain; Region: GAF; cl00853 262316008414 GAF domain; Region: GAF; cl00853 262316008415 Histidine kinase; Region: HisKA_3; pfam07730 262316008416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316008417 ATP binding site [chemical binding]; other site 262316008418 Mg2+ binding site [ion binding]; other site 262316008419 G-X-G motif; other site 262316008420 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262316008421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316008422 active site 262316008423 phosphorylation site [posttranslational modification] 262316008424 intermolecular recognition site; other site 262316008425 dimerization interface [polypeptide binding]; other site 262316008426 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 262316008427 DNA binding residues [nucleotide binding] 262316008428 dimerization interface [polypeptide binding]; other site 262316008429 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316008430 hypothetical protein; Provisional; Region: PRK07877 262316008431 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 262316008432 dimer interface [polypeptide binding]; other site 262316008433 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 262316008434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 262316008435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316008436 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262316008437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316008438 active site 262316008439 phosphorylation site [posttranslational modification] 262316008440 intermolecular recognition site; other site 262316008441 dimerization interface [polypeptide binding]; other site 262316008442 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 262316008443 DNA binding residues [nucleotide binding] 262316008444 dimerization interface [polypeptide binding]; other site 262316008445 Acyltransferase family; Region: Acyl_transf_3; pfam01757 262316008446 yiaA/B two helix domain; Region: YiaAB; cl01759 262316008447 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 262316008448 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 262316008449 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 262316008450 FMN-binding pocket [chemical binding]; other site 262316008451 flavin binding motif; other site 262316008452 phosphate binding motif [ion binding]; other site 262316008453 beta-alpha-beta structure motif; other site 262316008454 NAD binding pocket [chemical binding]; other site 262316008455 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316008456 catalytic loop [active] 262316008457 iron binding site [ion binding]; other site 262316008458 short chain dehydrogenase; Validated; Region: PRK05855 262316008459 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316008460 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 262316008461 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 262316008462 acyl-CoA synthetase; Validated; Region: PRK05850 262316008463 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316008464 thioester reductase domain; Region: Thioester-redct; TIGR01746 262316008465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008466 NAD(P) binding site [chemical binding]; other site 262316008467 active site 262316008468 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 262316008469 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 262316008470 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316008471 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316008472 short chain dehydrogenase; Provisional; Region: PRK06197 262316008473 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 262316008474 putative NAD(P) binding site [chemical binding]; other site 262316008475 active site 262316008476 mce related protein; Region: MCE; pfam02470 262316008477 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316008478 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 262316008479 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 262316008480 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 262316008481 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 262316008482 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 262316008483 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 262316008484 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 262316008485 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316008486 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316008487 ATP binding site [chemical binding]; other site 262316008488 Transcription factor WhiB; Region: Whib; pfam02467 262316008489 UvrD/REP helicase; Region: UvrD-helicase; cl14126 262316008490 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 262316008491 HRDC domain; Region: HRDC; cl02578 262316008492 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 262316008493 catalytic residues [active] 262316008494 Ion channel; Region: Ion_trans_2; cl11596 262316008495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008496 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 262316008497 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 262316008498 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 262316008499 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 262316008500 putative NADH binding site [chemical binding]; other site 262316008501 putative active site [active] 262316008502 nudix motif; other site 262316008503 putative metal binding site [ion binding]; other site 262316008504 UvrD/REP helicase; Region: UvrD-helicase; cl14126 262316008505 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 262316008506 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 262316008507 UvrD/REP helicase; Region: UvrD-helicase; cl14126 262316008508 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 262316008509 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 262316008510 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316008511 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316008512 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 262316008513 DNA binding site [nucleotide binding] 262316008514 active site 262316008515 TIGR02569 family protein; Region: TIGR02569_actnb 262316008516 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 262316008517 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 262316008518 ATP binding site [chemical binding]; other site 262316008519 substrate interface [chemical binding]; other site 262316008520 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 262316008521 active site residue [active] 262316008522 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 262316008523 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008525 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 262316008526 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 262316008527 dinuclear metal binding motif [ion binding]; other site 262316008528 helicase 45; Provisional; Region: PTZ00424 262316008529 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 262316008530 ATP binding site [chemical binding]; other site 262316008531 Mg++ binding site [ion binding]; other site 262316008532 motif III; other site 262316008533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316008534 nucleotide binding region [chemical binding]; other site 262316008535 ATP-binding site [chemical binding]; other site 262316008536 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 262316008537 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 262316008538 P-loop; other site 262316008539 Magnesium ion binding site [ion binding]; other site 262316008540 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 262316008541 Magnesium ion binding site [ion binding]; other site 262316008542 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316008543 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 262316008544 catalytic core [active] 262316008545 isochorismate synthase DhbC; Validated; Region: PRK06923 262316008546 chorismate binding enzyme; Region: Chorismate_bind; cl10555 262316008547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316008548 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 262316008549 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 262316008550 Transcription factor WhiB; Region: Whib; pfam02467 262316008551 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 262316008552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 262316008553 Histidine kinase; Region: HisKA_2; cl06527 262316008554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316008555 ATP binding site [chemical binding]; other site 262316008556 Mg2+ binding site [ion binding]; other site 262316008557 G-X-G motif; other site 262316008558 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 262316008559 carboxyltransferase (CT) interaction site; other site 262316008560 biotinylation site [posttranslational modification]; other site 262316008561 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 262316008562 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 262316008563 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316008564 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 262316008565 DNA binding residues [nucleotide binding] 262316008566 short chain dehydrogenase; Provisional; Region: PRK08278 262316008567 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 262316008568 NAD(P) binding site [chemical binding]; other site 262316008569 homodimer interface [polypeptide binding]; other site 262316008570 active site 262316008571 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262316008572 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 262316008573 NAD(P) binding site [chemical binding]; other site 262316008574 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 262316008575 tropinone reductase; Provisional; Region: PRK09242 262316008576 classical (c) SDRs; Region: SDR_c; cd05233 262316008577 NAD(P) binding site [chemical binding]; other site 262316008578 active site 262316008579 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316008580 classical (c) SDRs; Region: SDR_c; cd05233 262316008581 NAD(P) binding site [chemical binding]; other site 262316008582 active site 262316008583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 262316008584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008585 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316008586 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316008587 active site 262316008588 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 262316008589 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 262316008590 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 262316008591 hinge; other site 262316008592 active site 262316008593 Predicted GTPases [General function prediction only]; Region: COG1162 262316008594 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 262316008595 GTPase/OB domain interface [polypeptide binding]; other site 262316008596 GTPase/Zn-binding domain interface [polypeptide binding]; other site 262316008597 GTP/Mg2+ binding site [chemical binding]; other site 262316008598 G4 box; other site 262316008599 G5 box; other site 262316008600 G1 box; other site 262316008601 Switch I region; other site 262316008602 G2 box; other site 262316008603 G3 box; other site 262316008604 Switch II region; other site 262316008605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316008606 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 262316008607 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316008608 dimer interface [polypeptide binding]; other site 262316008609 active site 262316008610 Domain of unknown function DUF302; Region: DUF302; cl01364 262316008611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008614 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 262316008615 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 262316008616 putative di-iron ligands [ion binding]; other site 262316008617 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 262316008618 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 262316008619 FAD binding pocket [chemical binding]; other site 262316008620 FAD binding motif [chemical binding]; other site 262316008621 phosphate binding motif [ion binding]; other site 262316008622 beta-alpha-beta structure motif; other site 262316008623 NAD binding pocket [chemical binding]; other site 262316008624 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316008625 catalytic loop [active] 262316008626 iron binding site [ion binding]; other site 262316008627 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 262316008628 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316008629 Condensation domain; Region: Condensation; cl09290 262316008630 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 262316008631 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 262316008632 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 262316008633 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 262316008634 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 262316008635 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262316008636 Zn2+ binding site [ion binding]; other site 262316008637 Mg2+ binding site [ion binding]; other site 262316008638 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 262316008639 DNA binding residues [nucleotide binding] 262316008640 dimerization interface [polypeptide binding]; other site 262316008641 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 262316008642 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 262316008643 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 262316008644 30S subunit binding site; other site 262316008645 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 262316008646 Transposase domain (DUF772); Region: DUF772; cl12084 262316008647 lipoprotein LpqB; Provisional; Region: PRK13616 262316008648 Sporulation and spore germination; Region: Germane; cl11253 262316008649 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 262316008650 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 262316008651 dimerization interface [polypeptide binding]; other site 262316008652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 262316008653 dimer interface [polypeptide binding]; other site 262316008654 phosphorylation site [posttranslational modification] 262316008655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316008656 ATP binding site [chemical binding]; other site 262316008657 Mg2+ binding site [ion binding]; other site 262316008658 G-X-G motif; other site 262316008659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316008660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316008661 active site 262316008662 phosphorylation site [posttranslational modification] 262316008663 intermolecular recognition site; other site 262316008664 dimerization interface [polypeptide binding]; other site 262316008665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 262316008666 DNA binding site [nucleotide binding] 262316008667 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 262316008668 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 262316008669 TMP-binding site; other site 262316008670 Adenosylhomocysteinase; Provisional; Region: PTZ00075 262316008671 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 262316008672 oligomerization interface [polypeptide binding]; other site 262316008673 active site 262316008674 NAD+ binding site [chemical binding]; other site 262316008675 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 262316008676 Di-iron ligands [ion binding]; other site 262316008677 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 262316008678 ethanolamine permease; Region: 2A0305; TIGR00908 262316008679 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 262316008680 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 262316008681 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 262316008682 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 262316008683 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 262316008684 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 262316008685 active site 262316008686 substrate binding site [chemical binding]; other site 262316008687 metal binding site [ion binding]; metal-binding site 262316008688 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 262316008689 Transcription factor WhiB; Region: Whib; pfam02467 262316008690 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 262316008691 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 262316008692 dimer interface [polypeptide binding]; other site 262316008693 phosphate binding site [ion binding]; other site 262316008694 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 262316008695 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 262316008696 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 262316008697 FMN binding site [chemical binding]; other site 262316008698 dimer interface [polypeptide binding]; other site 262316008699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316008700 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 262316008701 nudix motif; other site 262316008702 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 262316008703 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 262316008704 active site 262316008705 Substrate binding site [chemical binding]; other site 262316008706 Mg++ binding site [ion binding]; other site 262316008707 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 262316008708 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 262316008709 Probable Catalytic site [active] 262316008710 metal binding site [ion binding]; metal-binding site 262316008711 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 262316008712 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 262316008713 NADP binding site [chemical binding]; other site 262316008714 active site 262316008715 putative substrate binding site [chemical binding]; other site 262316008716 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 262316008717 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316008718 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 262316008719 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 262316008720 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262316008721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 262316008722 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316008723 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316008724 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316008725 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316008726 active site 262316008727 ATP binding site [chemical binding]; other site 262316008728 substrate binding site [chemical binding]; other site 262316008729 activation loop (A-loop); other site 262316008730 Uncharacterized conserved protein [Function unknown]; Region: COG3391 262316008731 NHL repeat; Region: NHL; pfam01436 262316008732 NHL repeat; Region: NHL; pfam01436 262316008733 NHL repeat; Region: NHL; pfam01436 262316008734 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316008735 Response regulator receiver domain; Region: Response_reg; pfam00072 262316008736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316008737 active site 262316008738 phosphorylation site [posttranslational modification] 262316008739 intermolecular recognition site; other site 262316008740 dimerization interface [polypeptide binding]; other site 262316008741 CHASE3 domain; Region: CHASE3; cl05000 262316008742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262316008743 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 262316008744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 262316008745 dimer interface [polypeptide binding]; other site 262316008746 phosphorylation site [posttranslational modification] 262316008747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316008748 ATP binding site [chemical binding]; other site 262316008749 Mg2+ binding site [ion binding]; other site 262316008750 G-X-G motif; other site 262316008751 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 262316008752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316008753 active site 262316008754 phosphorylation site [posttranslational modification] 262316008755 intermolecular recognition site; other site 262316008756 dimerization interface [polypeptide binding]; other site 262316008757 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 262316008758 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316008759 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 262316008760 FAD binding site [chemical binding]; other site 262316008761 homotetramer interface [polypeptide binding]; other site 262316008762 substrate binding pocket [chemical binding]; other site 262316008763 catalytic base [active] 262316008764 AIR carboxylase; Region: AIRC; cl00310 262316008765 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 262316008766 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316008767 GtrA-like protein; Region: GtrA; cl00971 262316008768 Bacterial membrane flanked domain; Region: DUF304; cl01348 262316008769 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 262316008770 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 262316008771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008772 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 262316008773 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316008774 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 262316008775 Maf-like protein; Region: Maf; pfam02545 262316008776 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 262316008777 active site 262316008778 dimer interface [polypeptide binding]; other site 262316008779 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 262316008780 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 262316008781 active site residue [active] 262316008782 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 262316008783 active site residue [active] 262316008784 Fe-S metabolism associated domain; Region: SufE; cl00951 262316008785 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 262316008786 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316008787 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316008788 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 262316008789 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 262316008790 carboxyltransferase (CT) interaction site; other site 262316008791 biotinylation site [posttranslational modification]; other site 262316008792 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316008793 anti sigma factor interaction site; other site 262316008794 regulatory phosphorylation site [posttranslational modification]; other site 262316008795 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 262316008796 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316008797 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 262316008798 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 262316008799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316008800 L-lysine aminotransferase; Provisional; Region: PRK08297 262316008801 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 262316008802 inhibitor-cofactor binding pocket; inhibition site 262316008803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316008804 catalytic residue [active] 262316008805 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 262316008806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316008807 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 262316008808 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 262316008809 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316008810 tetrameric interface [polypeptide binding]; other site 262316008811 NAD binding site [chemical binding]; other site 262316008812 catalytic residues [active] 262316008813 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316008816 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 262316008817 ATP binding site [chemical binding]; other site 262316008818 putative Mg++ binding site [ion binding]; other site 262316008819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316008820 nucleotide binding region [chemical binding]; other site 262316008821 ATP-binding site [chemical binding]; other site 262316008822 DEAD/H associated; Region: DEAD_assoc; pfam08494 262316008823 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 262316008824 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 262316008825 putative DNA binding site [nucleotide binding]; other site 262316008826 catalytic residue [active] 262316008827 putative H2TH interface [polypeptide binding]; other site 262316008828 putative catalytic residues [active] 262316008829 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 262316008830 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262316008831 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 262316008832 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316008833 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316008834 PPE family; Region: PPE; pfam00823 262316008835 PPE family; Region: PPE; pfam00823 262316008836 PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558 262316008837 probable active site [active] 262316008838 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 262316008839 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 262316008840 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 262316008841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008843 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262316008844 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 262316008845 putative active site pocket [active] 262316008846 dimerization interface [polypeptide binding]; other site 262316008847 putative catalytic residue [active] 262316008848 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 262316008849 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 262316008850 metal binding site [ion binding]; metal-binding site 262316008851 putative dimer interface [polypeptide binding]; other site 262316008852 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 262316008853 amidohydrolase; Region: amidohydrolases; TIGR01891 262316008854 metal binding site [ion binding]; metal-binding site 262316008855 Cutinase; Region: Cutinase; pfam01083 262316008856 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 262316008857 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 262316008858 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 262316008859 active site 262316008860 substrate binding site [chemical binding]; other site 262316008861 metal binding site [ion binding]; metal-binding site 262316008862 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 262316008863 Sulfatase; Region: Sulfatase; cl10460 262316008864 hypothetical protein; Provisional; Region: PRK13685 262316008865 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 262316008866 metal ion-dependent adhesion site (MIDAS); other site 262316008867 hypothetical protein; Provisional; Region: PRK13685 262316008868 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 262316008869 metal ion-dependent adhesion site (MIDAS); other site 262316008870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 262316008871 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316008872 active site 262316008873 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 262316008874 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 262316008875 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 262316008876 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 262316008877 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 262316008878 active site 262316008879 catalytic motif [active] 262316008880 Zn binding site [ion binding]; other site 262316008881 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 262316008882 putative Iron-sulfur protein interface [polypeptide binding]; other site 262316008883 putative proximal heme binding site [chemical binding]; other site 262316008884 putative SdhD-like interface [polypeptide binding]; other site 262316008885 putative distal heme binding site [chemical binding]; other site 262316008886 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 262316008887 putative Iron-sulfur protein interface [polypeptide binding]; other site 262316008888 putative proximal heme binding site [chemical binding]; other site 262316008889 putative SdhC-like subunit interface [polypeptide binding]; other site 262316008890 putative distal heme binding site [chemical binding]; other site 262316008891 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 262316008892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008893 domain; Region: Succ_DH_flav_C; pfam02910 262316008894 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 262316008895 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316008896 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 262316008897 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316008898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 262316008899 hypothetical protein; Provisional; Region: PRK06541 262316008900 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 262316008901 inhibitor-cofactor binding pocket; inhibition site 262316008902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316008903 catalytic residue [active] 262316008904 Beta-lactamase; Region: Beta-lactamase; cl01009 262316008905 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 262316008906 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 262316008907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316008908 putative substrate translocation pore; other site 262316008909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316008910 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316008911 active site 262316008912 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 262316008913 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 262316008914 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 262316008915 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 262316008916 active site 262316008917 HIGH motif; other site 262316008918 dimer interface [polypeptide binding]; other site 262316008919 KMSKS motif; other site 262316008920 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316008921 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 262316008922 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 262316008923 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 262316008924 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 262316008925 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 262316008926 homodimer interface [polypeptide binding]; other site 262316008927 substrate-cofactor binding pocket; other site 262316008928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316008929 catalytic residue [active] 262316008930 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316008931 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 262316008932 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 262316008933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316008934 S-adenosylmethionine binding site [chemical binding]; other site 262316008935 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316008936 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316008937 active site 262316008938 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316008939 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 262316008940 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 262316008941 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 262316008942 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 262316008943 homodimer interface [polypeptide binding]; other site 262316008944 NADP binding site [chemical binding]; other site 262316008945 substrate binding site [chemical binding]; other site 262316008946 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 262316008947 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 262316008948 active site 262316008949 FMN binding site [chemical binding]; other site 262316008950 substrate binding site [chemical binding]; other site 262316008951 putative catalytic residue [active] 262316008952 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316008953 phosphopeptide binding site; other site 262316008954 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316008955 phosphopeptide binding site; other site 262316008956 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with...; Region: ABCG_EPDR; cd03213 262316008957 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 262316008958 Walker A/P-loop; other site 262316008959 ATP binding site [chemical binding]; other site 262316008960 Q-loop/lid; other site 262316008961 ABC transporter signature motif; other site 262316008962 Walker B; other site 262316008963 D-loop; other site 262316008964 H-loop/switch region; other site 262316008965 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316008966 phosphopeptide binding site; other site 262316008967 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316008968 phosphopeptide binding site; other site 262316008969 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 262316008970 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with...; Region: ABCG_EPDR; cd03213 262316008971 Walker A/P-loop; other site 262316008972 ATP binding site [chemical binding]; other site 262316008973 Q-loop/lid; other site 262316008974 ABC transporter signature motif; other site 262316008975 Walker B; other site 262316008976 D-loop; other site 262316008977 H-loop/switch region; other site 262316008978 ABC-2 type transporter; Region: ABC2_membrane; cl11417 262316008979 Transposase domain (DUF772); Region: DUF772; cl12084 262316008980 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 262316008981 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 262316008982 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 262316008983 G1 box; other site 262316008984 GTP/Mg2+ binding site [chemical binding]; other site 262316008985 G2 box; other site 262316008986 Switch I region; other site 262316008987 G3 box; other site 262316008988 Switch II region; other site 262316008989 G4 box; other site 262316008990 G5 box; other site 262316008991 Protein of unknown function (DUF742); Region: DUF742; pfam05331 262316008992 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 262316008993 sensory histidine kinase CreC; Provisional; Region: PRK11100 262316008994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316008995 ATP binding site [chemical binding]; other site 262316008996 Mg2+ binding site [ion binding]; other site 262316008997 G-X-G motif; other site 262316008998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316008999 S-adenosylmethionine binding site [chemical binding]; other site 262316009000 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 262316009001 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 262316009002 FMN binding site [chemical binding]; other site 262316009003 dimer interface [polypeptide binding]; other site 262316009004 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 262316009005 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 262316009006 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 262316009007 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 262316009008 generic binding surface II; other site 262316009009 generic binding surface I; other site 262316009010 Condensation domain; Region: Condensation; cl09290 262316009011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 262316009012 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 262316009013 enoyl-CoA hydratase; Region: PLN02864 262316009014 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 262316009015 dimer interaction site [polypeptide binding]; other site 262316009016 substrate-binding tunnel; other site 262316009017 active site 262316009018 catalytic site [active] 262316009019 substrate binding site [chemical binding]; other site 262316009020 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316009021 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316009022 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316009023 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 262316009024 catalytic core [active] 262316009025 short chain dehydrogenase; Provisional; Region: PRK07201 262316009026 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 262316009027 putative NAD(P) binding site [chemical binding]; other site 262316009028 active site 262316009029 putative substrate binding site [chemical binding]; other site 262316009030 classical (c) SDRs; Region: SDR_c; cd05233 262316009031 NAD(P) binding site [chemical binding]; other site 262316009032 active site 262316009033 Uncharacterized protein conserved in bacteria (DUF2257); Region: DUF2257; cl01794 262316009034 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_3; cd02653 262316009035 active site 262316009036 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 262316009037 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 262316009038 dimer interface [polypeptide binding]; other site 262316009039 active site 262316009040 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 262316009041 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 262316009042 putative active site [active] 262316009043 putative substrate binding site [chemical binding]; other site 262316009044 putative FMN binding site [chemical binding]; other site 262316009045 putative catalytic residues [active] 262316009046 Y-family of DNA polymerases; Region: PolY; cl12025 262316009047 DNA binding site [nucleotide binding] 262316009048 GMP synthase; Reviewed; Region: guaA; PRK00074 262316009049 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 262316009050 AMP/PPi binding site [chemical binding]; other site 262316009051 candidate oxyanion hole; other site 262316009052 catalytic triad [active] 262316009053 potential glutamine specificity residues [chemical binding]; other site 262316009054 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 262316009055 ATP Binding subdomain [chemical binding]; other site 262316009056 Ligand Binding sites [chemical binding]; other site 262316009057 Dimerization subdomain; other site 262316009058 PPE family; Region: PPE; pfam00823 262316009059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 262316009060 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 262316009061 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 262316009062 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 262316009063 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 262316009064 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316009065 NAD(P) binding site [chemical binding]; other site 262316009066 catalytic residues [active] 262316009067 Cutinase; Region: Cutinase; pfam01083 262316009068 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 262316009069 classical (c) SDRs; Region: SDR_c; cd05233 262316009070 NAD(P) binding site [chemical binding]; other site 262316009071 active site 262316009072 acyl-CoA synthetase; Provisional; Region: PRK13383 262316009073 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316009074 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262316009075 golgi membrane calcium-translocating P-type ATPase; Region: ATPase-IIA2_Ca; TIGR01522 262316009076 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 262316009077 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 262316009078 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316009079 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316009080 hydrophobic ligand binding site; other site 262316009081 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 262316009082 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 262316009083 NAD binding site [chemical binding]; other site 262316009084 catalytic Zn binding site [ion binding]; other site 262316009085 substrate binding site [chemical binding]; other site 262316009086 structural Zn binding site [ion binding]; other site 262316009087 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 262316009088 classical (c) SDRs; Region: SDR_c; cd05233 262316009089 NAD(P) binding site [chemical binding]; other site 262316009090 active site 262316009091 AMP-binding enzyme; Region: AMP-binding; pfam00501 262316009092 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316009093 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 262316009094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316009095 DNA-binding site [nucleotide binding]; DNA binding site 262316009096 UTRA domain; Region: UTRA; cl01230 262316009097 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 262316009098 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 262316009099 classical (c) SDRs; Region: SDR_c; cd05233 262316009100 NAD(P) binding site [chemical binding]; other site 262316009101 active site 262316009102 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316009103 [2Fe-2S] cluster binding site [ion binding]; other site 262316009104 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 262316009105 putative alpha subunit interface [polypeptide binding]; other site 262316009106 putative active site [active] 262316009107 putative substrate binding site [chemical binding]; other site 262316009108 Fe binding site [ion binding]; other site 262316009109 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316009110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009111 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316009112 NAD(P) binding site [chemical binding]; other site 262316009113 active site 262316009114 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316009115 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 262316009116 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316009117 PYR/PP interface [polypeptide binding]; other site 262316009118 dimer interface [polypeptide binding]; other site 262316009119 TPP binding site [chemical binding]; other site 262316009120 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316009121 TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules...; Region: TPP_BZL_OCoD_HPCL; cd02004 262316009122 TPP-binding site; other site 262316009123 dimer interface [polypeptide binding]; other site 262316009124 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 262316009125 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316009126 NAD binding site [chemical binding]; other site 262316009127 catalytic residues [active] 262316009128 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316009129 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 262316009130 active site 262316009131 catalytic triad [active] 262316009132 oxyanion hole [active] 262316009133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316009134 S-adenosylmethionine binding site [chemical binding]; other site 262316009135 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 262316009136 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 262316009137 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 262316009138 putative NAD(P) binding site [chemical binding]; other site 262316009139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 262316009140 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 262316009141 Isochorismatase family; Region: Isochorismatase; pfam00857 262316009142 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 262316009143 catalytic triad [active] 262316009144 conserved cis-peptide bond; other site 262316009145 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262316009146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316009147 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 262316009148 dimerization interface [polypeptide binding]; other site 262316009149 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 262316009150 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316009151 PYR/PP interface [polypeptide binding]; other site 262316009152 dimer interface [polypeptide binding]; other site 262316009153 TPP binding site [chemical binding]; other site 262316009154 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316009155 TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules...; Region: TPP_BZL_OCoD_HPCL; cd02004 262316009156 TPP-binding site; other site 262316009157 dimer interface [polypeptide binding]; other site 262316009158 acyl-CoA synthetase; Validated; Region: PRK05852 262316009159 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316009160 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 262316009161 elongation factor G; Reviewed; Region: PRK12740 262316009162 G1 box; other site 262316009163 putative GEF interaction site [polypeptide binding]; other site 262316009164 GTP/Mg2+ binding site [chemical binding]; other site 262316009165 Switch I region; other site 262316009166 G2 box; other site 262316009167 G3 box; other site 262316009168 Switch II region; other site 262316009169 G4 box; other site 262316009170 G5 box; other site 262316009171 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 262316009172 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 262316009173 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 262316009174 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316009175 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 262316009176 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 262316009177 trehalose synthase; Region: treS_nterm; TIGR02456 262316009178 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 262316009179 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 262316009180 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 262316009181 Predicted esterase [General function prediction only]; Region: COG0627 262316009182 ABC-2 type transporter; Region: ABC2_membrane; cl11417 262316009183 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 262316009184 DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin. In addition to DrrA, the complex includes an integral membrane protein called DrrB. DrrA belongs to the...; Region: ABC_DrrA; cd03265 262316009185 Walker A/P-loop; other site 262316009186 ATP binding site [chemical binding]; other site 262316009187 Q-loop/lid; other site 262316009188 ABC transporter signature motif; other site 262316009189 Walker B; other site 262316009190 D-loop; other site 262316009191 H-loop/switch region; other site 262316009192 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 262316009193 active site 262316009194 metal binding site [ion binding]; metal-binding site 262316009195 homotetramer interface [polypeptide binding]; other site 262316009196 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 262316009197 putative homotetramer interface [polypeptide binding]; other site 262316009198 putative homodimer interface [polypeptide binding]; other site 262316009199 putative allosteric switch controlling residues; other site 262316009200 putative metal binding site [ion binding]; other site 262316009201 putative homodimer-homodimer interface [polypeptide binding]; other site 262316009202 Domain of unknown function DUF302; Region: DUF302; cl01364 262316009203 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316009204 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316009205 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 262316009206 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316009207 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 262316009208 putative active site [active] 262316009209 putative catalytic site [active] 262316009210 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009211 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316009212 active site 262316009213 ANTAR domain; Region: ANTAR; cl04297 262316009214 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 262316009215 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316009216 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316009217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316009218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009219 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 262316009220 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 262316009221 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 262316009222 FAD binding pocket [chemical binding]; other site 262316009223 FAD binding motif [chemical binding]; other site 262316009224 phosphate binding motif [ion binding]; other site 262316009225 beta-alpha-beta structure motif; other site 262316009226 NAD binding pocket [chemical binding]; other site 262316009227 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316009228 catalytic loop [active] 262316009229 iron binding site [ion binding]; other site 262316009230 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 262316009231 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 262316009232 putative di-iron ligands [ion binding]; other site 262316009233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009235 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316009236 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316009237 TOBE domain; Region: TOBE_2; cl01440 262316009238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009240 Cytochrome P450; Region: p450; cl12078 262316009241 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 262316009242 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316009243 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 262316009244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009245 NAD(P) binding site [chemical binding]; other site 262316009246 active site 262316009247 Domain of unknown function (DUF427); Region: DUF427; cl00998 262316009248 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316009249 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 262316009250 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 262316009251 minor groove reading motif; other site 262316009252 helix-hairpin-helix signature motif; other site 262316009253 active site 262316009254 Ferritin-like domain; Region: Ferritin; pfam00210 262316009255 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 262316009256 dimerization interface [polypeptide binding]; other site 262316009257 DPS ferroxidase diiron center [ion binding]; other site 262316009258 ion pore; other site 262316009259 Pirin-related protein [General function prediction only]; Region: COG1741 262316009260 Cupin domain; Region: Cupin_2; cl09118 262316009261 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 262316009262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009264 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316009265 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316009266 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 262316009267 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 262316009268 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 262316009269 NAD(P) binding site [chemical binding]; other site 262316009270 catalytic residues [active] 262316009271 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316009272 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 262316009273 NAD binding site [chemical binding]; other site 262316009274 homodimer interface [polypeptide binding]; other site 262316009275 active site 262316009276 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 262316009277 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 262316009278 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009279 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316009280 active site 262316009281 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316009282 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 262316009283 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 262316009284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009285 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 262316009286 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 262316009287 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009289 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316009290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009291 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316009292 NAD(P) binding site [chemical binding]; other site 262316009293 active site 262316009294 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 262316009295 FAD binding domain; Region: FAD_binding_4; pfam01565 262316009296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009298 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 262316009299 Strictosidine synthase; Region: Str_synth; pfam03088 262316009300 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 262316009301 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 262316009302 acyl-CoA thioesterase II; Region: tesB; TIGR00189 262316009303 active site 262316009304 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 262316009305 catalytic triad [active] 262316009306 dimer interface [polypeptide binding]; other site 262316009307 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316009308 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 262316009309 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009310 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316009311 active site 262316009312 Domain of unknown function (DUF427); Region: DUF427; cl00998 262316009313 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316009314 Cytochrome P450; Region: p450; cl12078 262316009315 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 262316009316 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262316009317 putative NAD(P) binding site [chemical binding]; other site 262316009318 catalytic Zn binding site [ion binding]; other site 262316009319 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 262316009320 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316009321 classical (c) SDRs; Region: SDR_c; cd05233 262316009322 NAD(P) binding site [chemical binding]; other site 262316009323 active site 262316009324 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316009325 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316009326 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316009327 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 262316009328 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 262316009329 NAD(P) binding site [chemical binding]; other site 262316009330 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 262316009331 active site 262316009332 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 262316009333 putative hydrophobic ligand binding site [chemical binding]; other site 262316009334 Transcriptional regulators [Transcription]; Region: FadR; COG2186 262316009335 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316009336 DNA-binding site [nucleotide binding]; DNA binding site 262316009337 FCD domain; Region: FCD; cl11656 262316009338 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 262316009339 AMP-binding enzyme; Region: AMP-binding; pfam00501 262316009340 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316009341 Domain of unknown function DUF140; Region: DUF140; cl00510 262316009342 Domain of unknown function DUF140; Region: DUF140; cl00510 262316009343 mce related protein; Region: MCE; pfam02470 262316009344 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316009345 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316009346 mce related protein; Region: MCE; pfam02470 262316009347 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316009348 mce related protein; Region: MCE; pfam02470 262316009349 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316009350 mce related protein; Region: MCE; pfam02470 262316009351 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316009352 mce related protein; Region: MCE; pfam02470 262316009353 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316009354 mce related protein; Region: MCE; pfam02470 262316009355 large tegument protein UL36; Provisional; Region: PHA03247 262316009356 RDD family; Region: RDD; cl00746 262316009357 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 262316009358 Translocon-associated protein beta (TRAPB); Region: TRAP_beta; pfam05753 262316009359 Predicted membrane protein [Function unknown]; Region: COG1511 262316009360 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 262316009361 Cupin domain; Region: Cupin_2; cl09118 262316009362 Pirin-related protein [General function prediction only]; Region: COG1741 262316009363 Transcriptional regulator [Transcription]; Region: IclR; COG1414 262316009364 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316009365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009366 RNA polymerase factor sigma-70; Validated; Region: PRK08241 262316009367 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316009368 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 262316009369 DNA binding residues [nucleotide binding] 262316009370 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316009371 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 262316009372 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316009373 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 262316009374 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 262316009375 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 262316009376 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 262316009377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316009378 S-adenosylmethionine binding site [chemical binding]; other site 262316009379 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 262316009380 FMN binding site [chemical binding]; other site 262316009381 substrate binding site [chemical binding]; other site 262316009382 putative catalytic residue [active] 262316009383 SPW repeat; Region: SPW; pfam03779 262316009384 SPW repeat; Region: SPW; pfam03779 262316009385 Dehydratase family; Region: ILVD_EDD; cl00340 262316009386 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 262316009387 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 262316009388 putative homotetramer interface [polypeptide binding]; other site 262316009389 putative homodimer interface [polypeptide binding]; other site 262316009390 putative allosteric switch controlling residues; other site 262316009391 putative metal binding site [ion binding]; other site 262316009392 putative homodimer-homodimer interface [polypeptide binding]; other site 262316009393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316009394 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 262316009395 putative substrate translocation pore; other site 262316009396 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 262316009397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009398 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 262316009399 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 262316009400 molybdopterin cofactor binding site; other site 262316009401 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 262316009402 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929 262316009403 molybdopterin cofactor binding site; other site 262316009404 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 262316009405 Predicted integral membrane protein [Function unknown]; Region: COG0392 262316009406 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 262316009407 Domain of unknown function DUF20; Region: UPF0118; cl00465 262316009408 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 262316009409 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 262316009410 putative metal binding site [ion binding]; other site 262316009411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316009412 S-adenosylmethionine binding site [chemical binding]; other site 262316009413 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 262316009414 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 262316009415 active site 262316009416 substrate-binding site [chemical binding]; other site 262316009417 metal-binding site [ion binding] 262316009418 GTP binding site [chemical binding]; other site 262316009419 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262316009420 metal binding site [ion binding]; metal-binding site 262316009421 active site 262316009422 I-site; other site 262316009423 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 262316009424 GAF domain; Region: GAF; cl00853 262316009425 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 262316009426 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316009427 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316009428 substrate binding site [chemical binding]; other site 262316009429 oxyanion hole (OAH) forming residues; other site 262316009430 trimer interface [polypeptide binding]; other site 262316009431 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009432 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316009433 active site 262316009434 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 262316009435 active site 2 [active] 262316009436 active site 1 [active] 262316009437 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 262316009438 putative active site [active] 262316009439 putative catalytic site [active] 262316009440 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316009441 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316009442 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316009443 active site 262316009444 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316009445 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316009446 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 262316009447 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316009448 substrate binding pocket [chemical binding]; other site 262316009449 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316009450 Condensation domain; Region: Condensation; cl09290 262316009451 enoyl-CoA hydratase; Provisional; Region: PRK08252 262316009452 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316009453 substrate binding site [chemical binding]; other site 262316009454 oxyanion hole (OAH) forming residues; other site 262316009455 trimer interface [polypeptide binding]; other site 262316009456 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 262316009457 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316009458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009460 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 262316009461 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316009462 NAD binding site [chemical binding]; other site 262316009463 catalytic residues [active] 262316009464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316009465 S-adenosylmethionine binding site [chemical binding]; other site 262316009466 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316009467 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316009468 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 262316009469 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316009470 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 262316009471 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active...; Region: PTE; cd00530 262316009472 active site 262316009473 substrate binding pocket [chemical binding]; other site 262316009474 homodimer interaction site [polypeptide binding]; other site 262316009475 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009476 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316009477 active site 262316009478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 262316009479 Integrase core domain; Region: rve; cl01316 262316009480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009482 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 262316009483 active site 262316009484 diiron metal binding site [ion binding]; other site 262316009485 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316009486 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 262316009487 NAD(P) binding site [chemical binding]; other site 262316009488 catalytic residues [active] 262316009489 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 262316009490 acetolactate synthase; Reviewed; Region: PRK08322 262316009491 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316009492 dimer interface [polypeptide binding]; other site 262316009493 PYR/PP interface [polypeptide binding]; other site 262316009494 TPP binding site [chemical binding]; other site 262316009495 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316009496 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 262316009497 TPP-binding site [chemical binding]; other site 262316009498 dimer interface [polypeptide binding]; other site 262316009499 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316009500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 262316009501 dimerization interface [polypeptide binding]; other site 262316009502 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 262316009503 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316009504 active site 262316009505 metal binding site [ion binding]; metal-binding site 262316009506 Predicted membrane protein [Function unknown]; Region: COG4129 262316009507 formate dehydrogenase; Provisional; Region: PRK07574 262316009508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009509 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 262316009510 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 262316009511 heme binding pocket [chemical binding]; other site 262316009512 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 262316009513 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 262316009514 heme binding pocket [chemical binding]; other site 262316009515 choline dehydrogenase; Validated; Region: PRK02106 262316009516 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 262316009517 Protein of unknown function (DUF1222); Region: DUF1222; pfam06762 262316009518 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 262316009519 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 262316009520 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 262316009521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009523 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-...; Region: ClC_like; cd01033 262316009524 putative ion selectivity filter; other site 262316009525 putative pore gating glutamate residue; other site 262316009526 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 262316009527 active site 2 [active] 262316009528 active site 1 [active] 262316009529 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 262316009530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009531 NAD(P) binding site [chemical binding]; other site 262316009532 active site 262316009533 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 262316009534 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316009535 dimer interface [polypeptide binding]; other site 262316009536 active site 262316009537 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 262316009538 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 262316009539 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 262316009540 FAD binding site [chemical binding]; other site 262316009541 substrate binding site [chemical binding]; other site 262316009542 catalytic residues [active] 262316009543 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 262316009544 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 262316009545 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 262316009546 Flavin Reductases; Region: FlaRed; cl00801 262316009547 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 262316009548 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316009549 catalytic loop [active] 262316009550 iron binding site [ion binding]; other site 262316009551 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 262316009552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009553 domain; Region: Succ_DH_flav_C; pfam02910 262316009554 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 262316009555 putative dimer interface [polypeptide binding]; other site 262316009556 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 262316009557 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 262316009558 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316009559 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 262316009560 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 262316009561 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 262316009562 putative active site [active] 262316009563 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_C; cd03414 262316009564 putative active site [active] 262316009565 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 262316009566 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 262316009567 active site 262316009568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316009569 DNA binding site [nucleotide binding] 262316009570 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 262316009571 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 262316009572 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 262316009573 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 262316009574 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 262316009575 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 262316009576 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 262316009577 intersubunit interface [polypeptide binding]; other site 262316009578 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 262316009579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009580 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 262316009581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316009582 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 262316009583 nucleotide binding site [chemical binding]; other site 262316009584 acyl-CoA synthetase; Validated; Region: PRK07788 262316009585 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316009586 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009587 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316009588 active site 262316009589 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009590 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 262316009591 FAD binding site [chemical binding]; other site 262316009592 substrate binding site [chemical binding]; other site 262316009593 catalytic base [active] 262316009594 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 262316009595 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009596 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 262316009597 Zn binding site [ion binding]; other site 262316009598 Condensation domain; Region: Condensation; cl09290 262316009599 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 262316009600 PPE family; Region: PPE; pfam00823 262316009601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 262316009602 dimer interface [polypeptide binding]; other site 262316009603 putative PBP binding regions; other site 262316009604 ABC-ATPase subunit interface; other site 262316009605 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 262316009606 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 262316009607 Walker A/P-loop; other site 262316009608 ATP binding site [chemical binding]; other site 262316009609 Q-loop/lid; other site 262316009610 ABC transporter signature motif; other site 262316009611 Walker B; other site 262316009612 D-loop; other site 262316009613 H-loop/switch region; other site 262316009614 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 262316009615 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 262316009616 intersubunit interface [polypeptide binding]; other site 262316009617 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 262316009618 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 262316009619 substrate binding pocket [chemical binding]; other site 262316009620 active site 262316009621 iron coordination sites [ion binding]; other site 262316009622 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 262316009623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316009624 S-adenosylmethionine binding site [chemical binding]; other site 262316009625 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262316009626 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 262316009627 Walker A/P-loop; other site 262316009628 ATP binding site [chemical binding]; other site 262316009629 Q-loop/lid; other site 262316009630 ABC transporter signature motif; other site 262316009631 Walker B; other site 262316009632 D-loop; other site 262316009633 H-loop/switch region; other site 262316009634 Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The...; Region: ABC_cobalt_CbiO_domain2; cd03226 262316009635 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 262316009636 Walker A/P-loop; other site 262316009637 ATP binding site [chemical binding]; other site 262316009638 Q-loop/lid; other site 262316009639 ABC transporter signature motif; other site 262316009640 Walker B; other site 262316009641 D-loop; other site 262316009642 H-loop/switch region; other site 262316009643 Cobalt transport protein; Region: CbiQ; cl00463 262316009644 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 262316009645 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262316009646 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316009647 Walker A/P-loop; other site 262316009648 ATP binding site [chemical binding]; other site 262316009649 Q-loop/lid; other site 262316009650 ABC transporter signature motif; other site 262316009651 Walker B; other site 262316009652 D-loop; other site 262316009653 H-loop/switch region; other site 262316009654 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 262316009655 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316009656 Walker A/P-loop; other site 262316009657 ATP binding site [chemical binding]; other site 262316009658 Q-loop/lid; other site 262316009659 ABC transporter signature motif; other site 262316009660 Walker B; other site 262316009661 D-loop; other site 262316009662 H-loop/switch region; other site 262316009663 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262316009664 PPE family; Region: PPE; pfam00823 262316009665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316009666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316009667 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262316009668 putative substrate translocation pore; other site 262316009669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316009670 putative substrate translocation pore; other site 262316009671 peptide synthase; Validated; Region: PRK05691 262316009672 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316009673 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316009674 Condensation domain; Region: Condensation; cl09290 262316009675 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316009676 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316009677 Condensation domain; Region: Condensation; cl09290 262316009678 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 262316009679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316009680 Condensation domain; Region: Condensation; cl09290 262316009681 Nonribosomal peptide synthase; Region: NRPS; pfam08415 262316009682 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316009683 Condensation domain; Region: Condensation; cl09290 262316009684 Condensation domain; Region: Condensation; cl09290 262316009685 Nonribosomal peptide synthase; Region: NRPS; pfam08415 262316009686 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316009687 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316009688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316009689 S-adenosylmethionine binding site [chemical binding]; other site 262316009690 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 262316009691 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316009692 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 262316009693 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 262316009694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009695 NAD(P) binding site [chemical binding]; other site 262316009696 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 262316009697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009698 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 262316009699 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 262316009700 putative homotetramer interface [polypeptide binding]; other site 262316009701 putative homodimer interface [polypeptide binding]; other site 262316009702 putative allosteric switch controlling residues; other site 262316009703 putative metal binding site [ion binding]; other site 262316009704 putative homodimer-homodimer interface [polypeptide binding]; other site 262316009705 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 262316009706 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 262316009707 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316009708 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316009709 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316009710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009711 NAD(P) binding site [chemical binding]; other site 262316009712 active site 262316009713 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316009714 Transport protein; Region: actII; TIGR00833 262316009715 acyl-CoA synthetase; Validated; Region: PRK05850 262316009716 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316009717 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316009718 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 262316009719 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 262316009720 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316009721 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 262316009722 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 262316009723 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316009724 MULE transposase domain; Region: MULE; pfam10551 262316009725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316009726 S-adenosylmethionine binding site [chemical binding]; other site 262316009727 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 262316009728 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 262316009729 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 262316009730 homodimer interface [polypeptide binding]; other site 262316009731 active site 262316009732 TDP-binding site; other site 262316009733 acceptor substrate-binding pocket; other site 262316009734 Condensation domain; Region: Condensation; cl09290 262316009735 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 262316009736 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316009737 active site 262316009738 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316009739 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316009740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009741 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316009742 Enoylreductase; Region: PKS_ER; smart00829 262316009743 NAD(P) binding site [chemical binding]; other site 262316009744 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 262316009745 putative NADP binding site [chemical binding]; other site 262316009746 active site 262316009747 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316009748 PPE family; Region: PPE; pfam00823 262316009749 Predicted permease; Region: DUF318; cl00487 262316009750 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 262316009751 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 262316009752 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 262316009753 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 262316009754 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 262316009755 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 262316009756 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 262316009757 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 262316009758 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 262316009759 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 262316009760 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 262316009761 metal binding site 2 [ion binding]; metal-binding site 262316009762 putative DNA binding helix; other site 262316009763 metal binding site 1 [ion binding]; metal-binding site 262316009764 dimer interface [polypeptide binding]; other site 262316009765 structural Zn2+ binding site [ion binding]; other site 262316009766 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 262316009767 ABC-ATPase subunit interface; other site 262316009768 dimer interface [polypeptide binding]; other site 262316009769 putative PBP binding regions; other site 262316009770 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 262316009771 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 262316009772 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 262316009773 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 262316009774 intersubunit interface [polypeptide binding]; other site 262316009775 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316009776 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 262316009777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316009778 Walker A motif; other site 262316009779 ATP binding site [chemical binding]; other site 262316009780 Walker B motif; other site 262316009781 arginine finger; other site 262316009782 Protein of unknown function (DUF690); Region: DUF690; cl04939 262316009783 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 262316009784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316009785 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 262316009786 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316009787 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316009788 PPE family; Region: PPE; pfam00823 262316009789 Proteins of 100 residues with WXG; Region: WXG100; cl02005 262316009790 secretion protein snm4; Region: sec_mycoba_snm4; TIGR02958 262316009791 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 262316009792 catalytic residues [active] 262316009793 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 262316009794 catalytic residues [active] 262316009795 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 262316009796 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316009797 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316009798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316009799 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 262316009800 Sulfatase; Region: Sulfatase; cl10460 262316009801 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(; Region: BluB; cd02145 262316009802 putative FMN binding site [chemical binding]; other site 262316009803 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 262316009804 active site 262316009805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 262316009806 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 262316009807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009809 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 262316009810 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 262316009811 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 262316009812 Prostaglandin dehydrogenases; Region: PGDH; cd05288 262316009813 NAD(P) binding site [chemical binding]; other site 262316009814 substrate binding site [chemical binding]; other site 262316009815 dimer interface [polypeptide binding]; other site 262316009816 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 262316009817 active site 262316009818 catalytic residues [active] 262316009819 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 262316009820 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 262316009821 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 262316009822 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 262316009823 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 262316009824 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 262316009825 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316009826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 262316009827 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 262316009828 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316009829 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316009830 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316009831 DNA binding site [nucleotide binding] 262316009832 active site 262316009833 Int/Topo IB signature motif; other site 262316009834 Protein of unknown function (DUF422); Region: DUF422; cl00991 262316009835 Cytochrome P450; Region: p450; cl12078 262316009836 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 262316009837 trimer interface [polypeptide binding]; other site 262316009838 active site 262316009839 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 262316009840 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262316009841 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 262316009842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009843 DinB superfamily; Region: DinB_2; cl00986 262316009844 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316009845 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 262316009846 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 262316009847 substrate binding site [chemical binding]; other site 262316009848 tetramer interface [polypeptide binding]; other site 262316009849 YibE/F-like protein; Region: YibE_F; cl02259 262316009850 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 262316009851 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316009852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316009853 homodimer interface [polypeptide binding]; other site 262316009854 catalytic residue [active] 262316009855 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 262316009856 Cysteine-rich domain; Region: CCG; pfam02754 262316009857 Cysteine-rich domain; Region: CCG; pfam02754 262316009858 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 262316009859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316009860 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 262316009861 putative substrate translocation pore; other site 262316009862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316009863 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 262316009864 RES domain; Region: RES; cl02411 262316009865 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 262316009866 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 262316009867 dimer interface [polypeptide binding]; other site 262316009868 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 262316009869 chaperone protein DnaJ; Provisional; Region: PRK14279 262316009870 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 262316009871 HSP70 interaction site [polypeptide binding]; other site 262316009872 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 262316009873 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 262316009874 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 262316009875 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 262316009876 DNA binding residues [nucleotide binding] 262316009877 putative dimer interface [polypeptide binding]; other site 262316009878 Predicted ATPase [General function prediction only]; Region: COG3899 262316009879 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 262316009880 cyclase homology domain; Region: CHD; cd07302 262316009881 nucleotidyl binding site; other site 262316009882 metal binding site [ion binding]; metal-binding site 262316009883 dimer interface [polypeptide binding]; other site 262316009884 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 262316009885 substrate binding pocket [chemical binding]; other site 262316009886 chain length determination region; other site 262316009887 substrate-Mg2+ binding site; other site 262316009888 catalytic residues [active] 262316009889 aspartate-rich region 1; other site 262316009890 active site lid residues [active] 262316009891 aspartate-rich region 2; other site 262316009892 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 262316009893 Uncharacterized conserved protein [Function unknown]; Region: COG3349 262316009894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009895 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 262316009896 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 262316009897 active site 262316009898 catalytic residues [active] 262316009899 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 262316009900 heme-binding site [chemical binding]; other site 262316009901 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 262316009902 FAD binding pocket [chemical binding]; other site 262316009903 FAD binding motif [chemical binding]; other site 262316009904 phosphate binding motif [ion binding]; other site 262316009905 beta-alpha-beta structure motif; other site 262316009906 NAD binding pocket [chemical binding]; other site 262316009907 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 262316009908 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 262316009909 Clp amino terminal domain; Region: Clp_N; pfam02861 262316009910 Clp amino terminal domain; Region: Clp_N; pfam02861 262316009911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316009912 Walker A motif; other site 262316009913 ATP binding site [chemical binding]; other site 262316009914 Walker B motif; other site 262316009915 arginine finger; other site 262316009916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316009917 Walker A motif; other site 262316009918 ATP binding site [chemical binding]; other site 262316009919 Walker B motif; other site 262316009920 arginine finger; other site 262316009921 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 262316009922 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262316009923 Integrase core domain; Region: rve; cl01316 262316009924 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262316009925 classical (c) SDRs; Region: SDR_c; cd05233 262316009926 NAD(P) binding site [chemical binding]; other site 262316009927 active site 262316009928 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 262316009929 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 262316009930 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 262316009931 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 262316009932 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 262316009933 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 262316009934 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 262316009935 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 262316009936 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 262316009937 Cation efflux family; Region: Cation_efflux; cl00316 262316009938 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 262316009939 active site 262316009940 putative substrate binding region [chemical binding]; other site 262316009941 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316009942 catalytic core [active] 262316009943 adenylosuccinate synthetase; Provisional; Region: PRK01117 262316009944 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 262316009945 GDP-binding site [chemical binding]; other site 262316009946 ACT binding site; other site 262316009947 IMP binding site; other site 262316009948 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316009949 CoenzymeA binding site [chemical binding]; other site 262316009950 subunit interaction site [polypeptide binding]; other site 262316009951 PHB binding site; other site 262316009952 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 262316009953 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 262316009954 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 262316009955 active site residue [active] 262316009956 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 262316009957 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 262316009958 homodimer interface [polypeptide binding]; other site 262316009959 substrate-cofactor binding pocket; other site 262316009960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316009961 catalytic residue [active] 262316009962 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 262316009963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009966 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009967 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316009968 active site 262316009969 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316009970 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009971 active site 262316009972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009973 NAD(P) binding site [chemical binding]; other site 262316009974 active site 262316009975 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 262316009976 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316009977 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316009978 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 262316009979 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316009980 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316009981 phosphate acetyltransferase; Reviewed; Region: PRK05632 262316009982 DRTGG domain; Region: DRTGG; cl12147 262316009983 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 262316009984 Acetokinase family; Region: Acetate_kinase; cl01029 262316009985 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 262316009986 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 262316009987 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316009988 Transport protein; Region: actII; TIGR00833 262316009989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009991 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316009992 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316009993 active site 262316009994 ATP binding site [chemical binding]; other site 262316009995 substrate binding site [chemical binding]; other site 262316009996 activation loop (A-loop); other site 262316009997 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 262316009998 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 262316009999 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 262316010000 substrate binding pocket [chemical binding]; other site 262316010001 membrane-bound complex binding site; other site 262316010002 hinge residues; other site 262316010003 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 262316010004 nudix motif; other site 262316010005 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 262316010006 active site 262316010007 thiamine phosphate binding site [chemical binding]; other site 262316010008 pyrophosphate binding site [ion binding]; other site 262316010009 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 262316010010 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 262316010011 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 262316010012 thiS-thiF/thiG interaction site; other site 262316010013 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 262316010014 ThiS interaction site; other site 262316010015 putative active site [active] 262316010016 tetramer interface [polypeptide binding]; other site 262316010017 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 262316010018 active site 262316010019 oxyanion hole [active] 262316010020 catalytic triad [active] 262316010021 Interferon-induced transmembrane protein; Region: CD225; pfam04505 262316010022 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 262316010023 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 262316010024 M28, and M42; Region: Zinc_peptidase_like; cl14876 262316010025 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 262316010026 PA/protease or protease-like domain interface [polypeptide binding]; other site 262316010027 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 262316010028 active site 262316010029 metal binding site [ion binding]; metal-binding site 262316010030 M28, and M42; Region: Zinc_peptidase_like; cl14876 262316010031 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 262316010032 PA/protease or protease-like domain interface [polypeptide binding]; other site 262316010033 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 262316010034 active site 262316010035 metal binding site [ion binding]; metal-binding site 262316010036 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 262316010037 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 262316010038 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316010039 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316010040 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 262316010041 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 262316010042 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 262316010043 dimer interface [polypeptide binding]; other site 262316010044 substrate binding site [chemical binding]; other site 262316010045 ATP binding site [chemical binding]; other site 262316010046 ThiC family; Region: ThiC; cl08031 262316010047 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 262316010048 putative phosphate binding site [ion binding]; other site 262316010049 putative catalytic site [active] 262316010050 active site 262316010051 metal binding site A [ion binding]; metal-binding site 262316010052 DNA binding site [nucleotide binding] 262316010053 putative AP binding site [nucleotide binding]; other site 262316010054 putative metal binding site B [ion binding]; other site 262316010055 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 262316010056 active site 262316010057 catalytic residues [active] 262316010058 metal binding site [ion binding]; metal-binding site 262316010059 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 262316010060 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 262316010061 E-class dimer interface [polypeptide binding]; other site 262316010062 P-class dimer interface [polypeptide binding]; other site 262316010063 active site 262316010064 Cu2+ binding site [ion binding]; other site 262316010065 Zn2+ binding site [ion binding]; other site 262316010066 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 262316010067 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 262316010068 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 262316010069 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316010070 enoyl-CoA hydratase; Provisional; Region: PRK08260 262316010071 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316010072 substrate binding site [chemical binding]; other site 262316010073 oxyanion hole (OAH) forming residues; other site 262316010074 trimer interface [polypeptide binding]; other site 262316010075 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 262316010076 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; cl08347 262316010077 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 262316010078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316010079 Walker A motif; other site 262316010080 ATP binding site [chemical binding]; other site 262316010081 Walker B motif; other site 262316010082 arginine finger; other site 262316010083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 262316010084 Walker A motif; other site 262316010085 ATP binding site [chemical binding]; other site 262316010086 Walker B motif; other site 262316010087 arginine finger; other site 262316010088 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 262316010089 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 262316010090 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 262316010091 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 262316010092 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 262316010093 dimer interface [polypeptide binding]; other site 262316010094 putative functional site; other site 262316010095 putative MPT binding site; other site 262316010096 short chain dehydrogenase; Provisional; Region: PRK06197 262316010097 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 262316010098 putative NAD(P) binding site [chemical binding]; other site 262316010099 active site 262316010100 Cupin domain; Region: Cupin_2; cl09118 262316010101 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 262316010102 active site 262316010103 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 262316010104 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 262316010105 ring oligomerisation interface [polypeptide binding]; other site 262316010106 ATP/Mg binding site [chemical binding]; other site 262316010107 stacking interactions; other site 262316010108 hinge regions; other site 262316010109 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 262316010110 PPE family; Region: PPE; pfam00823 262316010111 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 262316010112 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 262316010113 active site 262316010114 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316010115 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 262316010116 DinB superfamily; Region: DinB_2; cl00986 262316010117 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 262316010118 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 262316010119 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 262316010120 catalytic residues [active] 262316010121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010122 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316010123 Transport protein; Region: actII; TIGR00833 262316010124 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 262316010125 enoyl-CoA hydratase; Provisional; Region: PRK12478 262316010126 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316010127 substrate binding site [chemical binding]; other site 262316010128 oxyanion hole (OAH) forming residues; other site 262316010129 trimer interface [polypeptide binding]; other site 262316010130 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 262316010131 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316010132 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 262316010133 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316010134 NAD(P) binding site [chemical binding]; other site 262316010135 catalytic residues [active] 262316010136 Protein of unknown function (DUF779); Region: DUF779; cl01432 262316010137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010138 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 262316010139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010140 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262316010141 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316010142 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316010143 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262316010144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316010145 non-specific DNA binding site [nucleotide binding]; other site 262316010146 salt bridge; other site 262316010147 sequence-specific DNA binding site [nucleotide binding]; other site 262316010148 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 262316010149 Domain of unknown function (DUF955); Region: DUF955; cl01076 262316010150 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 262316010151 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 262316010152 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 262316010153 active site 262316010154 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 262316010155 tetramer interface [polypeptide binding]; other site 262316010156 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 262316010157 active site 262316010158 Mg2+/Mn2+ binding site [ion binding]; other site 262316010159 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 262316010160 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262316010161 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 262316010162 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316010163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316010164 S-adenosylmethionine binding site [chemical binding]; other site 262316010165 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316010166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316010167 S-adenosylmethionine binding site [chemical binding]; other site 262316010168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010170 Predicted membrane protein [Function unknown]; Region: COG2733 262316010171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262316010172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316010173 non-specific DNA binding site [nucleotide binding]; other site 262316010174 salt bridge; other site 262316010175 sequence-specific DNA binding site [nucleotide binding]; other site 262316010176 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 262316010177 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 262316010178 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 262316010179 catalytic residue [active] 262316010180 Predicted amidohydrolase [General function prediction only]; Region: COG0388 262316010181 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 262316010182 putative active site [active] 262316010183 catalytic triad [active] 262316010184 putative dimer interface [polypeptide binding]; other site 262316010185 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 262316010186 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 262316010187 FAD binding domain; Region: FAD_binding_4; pfam01565 262316010188 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 262316010189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 262316010190 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 262316010191 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316010192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010193 NAD(P) binding site [chemical binding]; other site 262316010194 active site 262316010195 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 262316010196 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 262316010197 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 262316010198 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 262316010199 putative ADP-binding pocket [chemical binding]; other site 262316010200 Protein of unknown function (DUF2596); Region: DUF2596; pfam10770 262316010201 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 262316010202 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316010203 catalytic core [active] 262316010204 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316010205 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 262316010206 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 262316010207 dimer interface [polypeptide binding]; other site 262316010208 phosphorylation site [posttranslational modification] 262316010209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316010210 ATP binding site [chemical binding]; other site 262316010211 Mg2+ binding site [ion binding]; other site 262316010212 G-X-G motif; other site 262316010213 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316010214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316010215 active site 262316010216 phosphorylation site [posttranslational modification] 262316010217 intermolecular recognition site; other site 262316010218 dimerization interface [polypeptide binding]; other site 262316010219 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 262316010220 DNA binding site [nucleotide binding] 262316010221 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 262316010222 nudix motif; other site 262316010223 exopolyphosphatase; Region: exo_poly_only; TIGR03706 262316010224 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 262316010225 dihydrolipoamide succinyltransferase; Provisional; Region: PTZ00144 262316010226 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 262316010227 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 262316010228 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 262316010229 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 262316010230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010231 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 262316010232 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316010233 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 262316010234 putative NAD(P) binding site [chemical binding]; other site 262316010235 active site 262316010236 putative substrate binding site [chemical binding]; other site 262316010237 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 262316010238 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 262316010239 putative acyl-acceptor binding pocket; other site 262316010240 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316010241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316010242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316010243 S-adenosylmethionine binding site [chemical binding]; other site 262316010244 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 262316010245 active site 262316010246 catalytic site [active] 262316010247 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 262316010248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 262316010249 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 262316010250 Proteins of 100 residues with WXG; Region: WXG100; cl02005 262316010251 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 262316010252 glutamyl-tRNA reductase; Region: hemA; TIGR01035 262316010253 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 262316010254 tRNA; other site 262316010255 putative tRNA binding site [nucleotide binding]; other site 262316010256 putative NADP binding site [chemical binding]; other site 262316010257 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 262316010258 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 262316010259 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 262316010260 domain interfaces; other site 262316010261 active site 262316010262 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 262316010263 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 262316010264 active site 262316010265 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 262316010266 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 262316010267 dimer interface [polypeptide binding]; other site 262316010268 active site 262316010269 Schiff base residues; other site 262316010270 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316010271 anti sigma factor interaction site; other site 262316010272 regulatory phosphorylation site [posttranslational modification]; other site 262316010273 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316010274 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 262316010275 active site 262316010276 catalytic triad [active] 262316010277 oxyanion hole [active] 262316010278 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316010279 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 262316010280 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316010281 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 262316010282 active site 262316010283 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 262316010284 dimer interface [polypeptide binding]; other site 262316010285 non-prolyl cis peptide bond; other site 262316010286 insertion regions; other site 262316010287 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 262316010288 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 262316010289 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 262316010290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010291 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 262316010292 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved...; Region: MR_like_1; cd03326 262316010293 putative active site pocket [active] 262316010294 metal binding site [ion binding]; metal-binding site 262316010295 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316010296 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 262316010297 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 262316010298 inhibitor-cofactor binding pocket; inhibition site 262316010299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316010300 catalytic residue [active] 262316010301 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316010302 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 262316010303 catalytic core [active] 262316010304 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 262316010305 catalytic residues [active] 262316010306 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 262316010307 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 262316010308 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 262316010309 ResB-like family; Region: ResB; pfam05140 262316010310 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 262316010311 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 262316010312 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 262316010313 P-loop; other site 262316010314 Magnesium ion binding site [ion binding]; other site 262316010315 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 262316010316 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 262316010317 dimer interface [polypeptide binding]; other site 262316010318 active site 262316010319 CoA binding pocket [chemical binding]; other site 262316010320 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 262316010321 UbiA prenyltransferase family; Region: UbiA; cl00337 262316010322 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 262316010323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010324 NAD(P) binding site [chemical binding]; other site 262316010325 active site 262316010326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010327 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 262316010328 Ligand binding site [chemical binding]; other site 262316010329 Putative Catalytic site [active] 262316010330 DXD motif; other site 262316010331 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316010332 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316010333 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 262316010334 Phosphate transporter family; Region: PHO4; cl00396 262316010335 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316010336 active site 262316010337 short chain dehydrogenase; Provisional; Region: PRK05866 262316010338 classical (c) SDRs; Region: SDR_c; cd05233 262316010339 NAD(P) binding site [chemical binding]; other site 262316010340 active site 262316010341 naphthoate synthase; Validated; Region: PRK08321 262316010342 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316010343 substrate binding site [chemical binding]; other site 262316010344 oxyanion hole (OAH) forming residues; other site 262316010345 trimer interface [polypeptide binding]; other site 262316010346 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 262316010347 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262316010348 active site 262316010349 catalytic tetrad [active] 262316010350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010351 acyl-CoA synthetase; Validated; Region: PRK06188 262316010352 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316010353 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 262316010354 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 262316010355 active site 262316010356 O-succinylbenzoate synthase; Provisional; Region: PRK02901 262316010357 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway...; Region: OSBS; cd03320 262316010358 active site 262316010359 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 262316010360 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316010361 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 262316010362 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 262316010363 dimer interface [polypeptide binding]; other site 262316010364 tetramer interface [polypeptide binding]; other site 262316010365 PYR/PP interface [polypeptide binding]; other site 262316010366 TPP binding site [chemical binding]; other site 262316010367 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 262316010368 TPP-binding site; other site 262316010369 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 262316010370 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316010371 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 262316010372 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 262316010373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316010374 S-adenosylmethionine binding site [chemical binding]; other site 262316010375 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316010376 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 262316010377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010378 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 262316010379 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 262316010380 substrate binding pocket [chemical binding]; other site 262316010381 chain length determination region; other site 262316010382 substrate-Mg2+ binding site; other site 262316010383 catalytic residues [active] 262316010384 aspartate-rich region 1; other site 262316010385 active site lid residues [active] 262316010386 aspartate-rich region 2; other site 262316010387 Peptidase family M48; Region: Peptidase_M48; cl12018 262316010388 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 262316010389 Sulfate transporter family; Region: Sulfate_transp; cl00967 262316010390 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 262316010391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010392 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 262316010393 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316010394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010395 Protein of unknown function (DUF520); Region: DUF520; cl00723 262316010396 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316010397 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 262316010398 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316010399 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316010400 Cytochrome P450; Region: p450; cl12078 262316010401 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 262316010402 putative metal binding site [ion binding]; other site 262316010403 Predicted membrane protein [Function unknown]; Region: COG1289 262316010404 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 262316010405 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 262316010406 dimer interface [polypeptide binding]; other site 262316010407 active site 262316010408 galactokinase; Provisional; Region: PRK00555 262316010409 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 262316010410 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 262316010411 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 262316010412 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 262316010413 PAS fold; Region: PAS_3; pfam08447 262316010414 ANTAR domain; Region: ANTAR; cl04297 262316010415 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 262316010416 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 262316010417 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 262316010418 serine/threonine kinase US3; Provisional; Region: PHA03209 262316010419 Predicted integral membrane protein [Function unknown]; Region: COG0392 262316010420 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 262316010421 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316010422 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316010423 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 262316010424 Transcriptional regulators [Transcription]; Region: FadR; COG2186 262316010425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316010426 DNA-binding site [nucleotide binding]; DNA binding site 262316010427 Domain of unknown function DUF140; Region: DUF140; cl00510 262316010428 Domain of unknown function DUF140; Region: DUF140; cl00510 262316010429 mce related protein; Region: MCE; pfam02470 262316010430 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316010431 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316010432 mce related protein; Region: MCE; pfam02470 262316010433 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316010434 mce related protein; Region: MCE; pfam02470 262316010435 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316010436 mce related protein; Region: MCE; pfam02470 262316010437 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316010438 mce related protein; Region: MCE; pfam02470 262316010439 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316010440 mce related protein; Region: MCE; pfam02470 262316010441 autotransport protein MisL; Provisional; Region: PRK15313 262316010442 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 262316010443 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 262316010444 UvrD/REP helicase; Region: UvrD-helicase; cl14126 262316010445 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 262316010446 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 262316010447 UvrD/REP helicase; Region: UvrD-helicase; cl14126 262316010448 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 262316010449 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 262316010450 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316010451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316010452 S-adenosylmethionine binding site [chemical binding]; other site 262316010453 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 262316010454 FMN binding site [chemical binding]; other site 262316010455 dimer interface [polypeptide binding]; other site 262316010456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316010457 S-adenosylmethionine binding site [chemical binding]; other site 262316010458 cyanate hydratase; Validated; Region: PRK02866 262316010459 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 262316010460 oligomer interface [polypeptide binding]; other site 262316010461 active site 262316010462 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 262316010463 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 262316010464 active site 262316010465 nucleophile elbow; other site 262316010466 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 262316010467 molybdopterin cofactor binding site; other site 262316010468 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508 262316010469 molybdopterin cofactor binding site; other site 262316010470 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316010471 substrate binding site [chemical binding]; other site 262316010472 oxyanion hole (OAH) forming residues; other site 262316010473 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316010474 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 262316010475 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 262316010476 active site 262316010477 catalytic site [active] 262316010478 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 262316010479 active site 262316010480 catalytic site [active] 262316010481 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 262316010482 active site 262316010483 catalytic site [active] 262316010484 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 262316010485 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 262316010486 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 262316010487 putative homodimer interface [polypeptide binding]; other site 262316010488 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 262316010489 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 262316010490 23S rRNA interface [nucleotide binding]; other site 262316010491 L7/L12 interface [polypeptide binding]; other site 262316010492 putative thiostrepton binding site; other site 262316010493 L25 interface [polypeptide binding]; other site 262316010494 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 262316010495 mRNA/rRNA interface [nucleotide binding]; other site 262316010496 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 262316010497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 262316010498 YCII-related domain; Region: YCII; cl00999 262316010499 YCII-related domain; Region: YCII; cl00999 262316010500 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316010501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316010502 S-adenosylmethionine binding site [chemical binding]; other site 262316010503 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316010504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 262316010505 S-adenosylmethionine binding site [chemical binding]; other site 262316010506 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316010507 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316010508 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 262316010509 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316010510 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 262316010511 active site 262316010512 ATP binding site [chemical binding]; other site 262316010513 DinB superfamily; Region: DinB_2; cl00986 262316010514 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 262316010515 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 262316010516 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 262316010517 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 262316010518 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 262316010519 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 262316010520 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 262316010521 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 262316010522 23S rRNA interface [nucleotide binding]; other site 262316010523 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 262316010524 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 262316010525 core dimer interface [polypeptide binding]; other site 262316010526 peripheral dimer interface [polypeptide binding]; other site 262316010527 L10 interface [polypeptide binding]; other site 262316010528 L11 interface [polypeptide binding]; other site 262316010529 putative EF-Tu interaction site [polypeptide binding]; other site 262316010530 putative EF-G interaction site [polypeptide binding]; other site 262316010531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010532 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 262316010533 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 262316010534 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 262316010535 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 262316010536 Walker A/P-loop; other site 262316010537 ATP binding site [chemical binding]; other site 262316010538 Q-loop/lid; other site 262316010539 ABC transporter signature motif; other site 262316010540 Walker B; other site 262316010541 D-loop; other site 262316010542 H-loop/switch region; other site 262316010543 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 262316010544 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 262316010545 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 262316010546 RPB10 interaction site [polypeptide binding]; other site 262316010547 RPB1 interaction site [polypeptide binding]; other site 262316010548 RPB11 interaction site [polypeptide binding]; other site 262316010549 RPB3 interaction site [polypeptide binding]; other site 262316010550 RPB12 interaction site [polypeptide binding]; other site 262316010551 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 262316010552 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 262316010553 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 262316010554 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 262316010555 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 262316010556 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 262316010557 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 262316010558 G-loop; other site 262316010559 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 262316010560 DNA binding site [nucleotide binding] 262316010561 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 262316010562 endonuclease IV; Provisional; Region: PRK01060 262316010563 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 262316010564 AP (apurinic/apyrimidinic) site pocket; other site 262316010565 DNA interaction; other site 262316010566 Metal-binding active site; metal-binding site 262316010567 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 262316010568 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316010569 active site 262316010570 enoyl-CoA hydratase; Provisional; Region: PRK08272 262316010571 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316010572 substrate binding site [chemical binding]; other site 262316010573 oxyanion hole (OAH) forming residues; other site 262316010574 trimer interface [polypeptide binding]; other site 262316010575 PaaX-like protein; Region: PaaX; pfam07848 262316010576 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 262316010577 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316010578 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 262316010579 substrate binding site [chemical binding]; other site 262316010580 oxyanion hole (OAH) forming residues; other site 262316010581 trimer interface [polypeptide binding]; other site 262316010582 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 262316010583 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 262316010584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010586 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 262316010587 S17 interaction site [polypeptide binding]; other site 262316010588 S8 interaction site; other site 262316010589 16S rRNA interaction site [nucleotide binding]; other site 262316010590 streptomycin interaction site [chemical binding]; other site 262316010591 23S rRNA interaction site [nucleotide binding]; other site 262316010592 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 262316010593 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 262316010594 elongation factor G; Reviewed; Region: PRK00007 262316010595 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 262316010596 G1 box; other site 262316010597 putative GEF interaction site [polypeptide binding]; other site 262316010598 GTP/Mg2+ binding site [chemical binding]; other site 262316010599 Switch I region; other site 262316010600 G2 box; other site 262316010601 G3 box; other site 262316010602 Switch II region; other site 262316010603 G4 box; other site 262316010604 G5 box; other site 262316010605 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 262316010606 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 262316010607 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 262316010608 elongation factor Tu; Reviewed; Region: PRK00049 262316010609 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 262316010610 G1 box; other site 262316010611 GEF interaction site [polypeptide binding]; other site 262316010612 GTP/Mg2+ binding site [chemical binding]; other site 262316010613 Switch I region; other site 262316010614 G2 box; other site 262316010615 G3 box; other site 262316010616 Switch II region; other site 262316010617 G4 box; other site 262316010618 G5 box; other site 262316010619 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 262316010620 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 262316010621 Antibiotic Binding Site [chemical binding]; other site 262316010622 PE family; Region: PE; pfam00934 262316010623 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316010624 classical (c) SDRs; Region: SDR_c; cd05233 262316010625 NAD(P) binding site [chemical binding]; other site 262316010626 active site 262316010627 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 262316010628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010629 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 262316010630 active site 262316010631 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 262316010632 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262316010633 active site 262316010634 catalytic tetrad [active] 262316010635 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 262316010636 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 262316010637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010638 mycofactocin system RPExFGAL proteinn; Region: Ac_RPExFGAL; TIGR03967 262316010639 radical SAM peptide maturase, mycofactocin system; Region: rSAM_MSMEG_1423; TIGR03962 262316010640 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 262316010641 FeS/SAM binding site; other site 262316010642 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 262316010643 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 262316010644 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 262316010645 phosphate binding site [ion binding]; other site 262316010646 Creatinine amidohydrolase; Region: Creatininase; cl00618 262316010647 mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965 262316010648 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 262316010649 mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965 262316010650 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316010651 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 262316010652 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 262316010653 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 262316010654 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 262316010655 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 262316010656 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 262316010657 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 262316010658 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 262316010659 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 262316010660 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 262316010661 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 262316010662 putative translocon binding site; other site 262316010663 protein-rRNA interface [nucleotide binding]; other site 262316010664 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 262316010665 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 262316010666 G-X-X-G motif; other site 262316010667 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 262316010668 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 262316010669 23S rRNA interface [nucleotide binding]; other site 262316010670 5S rRNA interface [nucleotide binding]; other site 262316010671 putative antibiotic binding site [chemical binding]; other site 262316010672 L25 interface [polypeptide binding]; other site 262316010673 L27 interface [polypeptide binding]; other site 262316010674 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 262316010675 putative translocon interaction site; other site 262316010676 signal recognition particle (SRP54) interaction site; other site 262316010677 L23 interface [polypeptide binding]; other site 262316010678 trigger factor interaction site; other site 262316010679 23S rRNA interface [nucleotide binding]; other site 262316010680 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 262316010681 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 262316010682 Sulfatase; Region: Sulfatase; cl10460 262316010683 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 262316010684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316010685 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 262316010686 Domain of unknown function DUF222; Region: DUF222; pfam02720 262316010687 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 262316010688 active site 262316010689 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 262316010690 KOW motif; Region: KOW; cl00354 262316010691 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 262316010692 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 262316010693 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 262316010694 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 262316010695 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 262316010696 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 262316010697 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 262316010698 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 262316010699 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 262316010700 5S rRNA interface [nucleotide binding]; other site 262316010701 L27 interface [polypeptide binding]; other site 262316010702 23S rRNA interface [nucleotide binding]; other site 262316010703 L5 interface [polypeptide binding]; other site 262316010704 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 262316010705 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 262316010706 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 262316010707 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 262316010708 23S rRNA binding site [nucleotide binding]; other site 262316010709 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 262316010710 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316010711 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316010712 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 262316010713 tandem repeat interface [polypeptide binding]; other site 262316010714 oligomer interface [polypeptide binding]; other site 262316010715 active site residues [active] 262316010716 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 262316010717 tandem repeat interface [polypeptide binding]; other site 262316010718 oligomer interface [polypeptide binding]; other site 262316010719 active site residues [active] 262316010720 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316010721 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316010722 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316010723 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 262316010724 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262316010725 NAD(P) binding site [chemical binding]; other site 262316010726 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 262316010727 intersubunit interface [polypeptide binding]; other site 262316010728 active site 262316010729 Zn2+ binding site [ion binding]; other site 262316010730 glyoxylate reductase; Reviewed; Region: PRK13243 262316010731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010732 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 262316010733 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 262316010734 N- and C-terminal domain interface [polypeptide binding]; other site 262316010735 active site 262316010736 MgATP binding site [chemical binding]; other site 262316010737 catalytic site [active] 262316010738 metal binding site [ion binding]; metal-binding site 262316010739 carbohydrate binding site [chemical binding]; other site 262316010740 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cl00148 262316010741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316010742 Coenzyme A binding pocket [chemical binding]; other site 262316010743 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316010744 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 262316010745 SecY translocase; Region: SecY; pfam00344 262316010746 adenylate kinase; Reviewed; Region: adk; PRK00279 262316010747 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 262316010748 AMP-binding site [chemical binding]; other site 262316010749 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 262316010750 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 262316010751 active site 262316010752 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 262316010753 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316010754 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 262316010755 DNA binding residues [nucleotide binding] 262316010756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 262316010759 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 262316010760 FtsX-like permease family; Region: FtsX; pfam02687 262316010761 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262316010762 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 262316010763 Walker A/P-loop; other site 262316010764 ATP binding site [chemical binding]; other site 262316010765 Q-loop/lid; other site 262316010766 ABC transporter signature motif; other site 262316010767 Walker B; other site 262316010768 D-loop; other site 262316010769 H-loop/switch region; other site 262316010770 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316010771 PYR/PP interface [polypeptide binding]; other site 262316010772 dimer interface [polypeptide binding]; other site 262316010773 TPP binding site [chemical binding]; other site 262316010774 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 262316010775 TPP-binding site [chemical binding]; other site 262316010776 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 262316010777 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 262316010778 active site 262316010779 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 262316010780 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316010781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316010782 homodimer interface [polypeptide binding]; other site 262316010783 catalytic residue [active] 262316010784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316010785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010786 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 262316010787 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316010788 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 262316010789 substrate binding pocket [chemical binding]; other site 262316010790 FAD binding site [chemical binding]; other site 262316010791 catalytic base [active] 262316010792 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 262316010793 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316010794 tetrameric interface [polypeptide binding]; other site 262316010795 NAD binding site [chemical binding]; other site 262316010796 catalytic residues [active] 262316010797 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316010798 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 262316010799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316010800 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 262316010801 DNA binding residues [nucleotide binding] 262316010802 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 262316010803 iron-sulfur cluster [ion binding]; other site 262316010804 [2Fe-2S] cluster binding site [ion binding]; other site 262316010805 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 262316010806 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 262316010807 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 262316010808 active site 262316010809 metal binding site [ion binding]; metal-binding site 262316010810 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316010811 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316010812 Cupin domain; Region: Cupin_2; cl09118 262316010813 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 262316010814 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 262316010815 NAD binding site [chemical binding]; other site 262316010816 substrate binding site [chemical binding]; other site 262316010817 homodimer interface [polypeptide binding]; other site 262316010818 active site 262316010819 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316010820 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316010821 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316010822 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 262316010823 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 262316010824 rRNA binding site [nucleotide binding]; other site 262316010825 predicted 30S ribosome binding site; other site 262316010826 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 262316010827 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 262316010828 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 262316010829 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 262316010830 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 262316010831 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 262316010832 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262316010833 RNA binding surface [nucleotide binding]; other site 262316010834 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 262316010835 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 262316010836 alphaNTD homodimer interface [polypeptide binding]; other site 262316010837 alphaNTD - beta interaction site [polypeptide binding]; other site 262316010838 alphaNTD - beta' interaction site [polypeptide binding]; other site 262316010839 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 262316010840 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 262316010841 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 262316010842 active site 262316010843 dimerization interface 3.5A [polypeptide binding]; other site 262316010844 Cutinase; Region: Cutinase; pfam01083 262316010845 Cutinase; Region: Cutinase; pfam01083 262316010846 Protein of unknown function (DUF690); Region: DUF690; cl04939 262316010847 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 262316010848 active site 262316010849 catalytic residues [active] 262316010850 secretion protein snm4; Region: sec_mycoba_snm4; TIGR02958 262316010851 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 262316010852 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316010853 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 262316010854 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316010855 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316010856 C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 262316010857 Proteins of 100 residues with WXG; Region: WXG100; cl02005 262316010858 Proteins of 100 residues with WXG; Region: WXG100; cl02005 262316010859 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 262316010860 23S rRNA interface [nucleotide binding]; other site 262316010861 L3 interface [polypeptide binding]; other site 262316010862 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 262316010863 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 262316010864 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 262316010865 active site 262316010866 substrate binding site [chemical binding]; other site 262316010867 metal binding site [ion binding]; metal-binding site 262316010868 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 262316010869 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316010870 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 262316010871 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 262316010872 glutaminase active site [active] 262316010873 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 262316010874 dimer interface [polypeptide binding]; other site 262316010875 active site 262316010876 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 262316010877 dimer interface [polypeptide binding]; other site 262316010878 active site 262316010879 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 262316010880 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 262316010881 putative substrate binding site [chemical binding]; other site 262316010882 putative ATP binding site [chemical binding]; other site 262316010883 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 262316010884 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 262316010885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316010886 catalytic residue [active] 262316010887 alanine racemase; Reviewed; Region: alr; PRK00053 262316010888 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 262316010889 active site 262316010890 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 262316010891 dimer interface [polypeptide binding]; other site 262316010892 substrate binding site [chemical binding]; other site 262316010893 catalytic residues [active] 262316010894 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316010895 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316010896 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 262316010897 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 262316010898 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 262316010899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316010900 Coenzyme A binding pocket [chemical binding]; other site 262316010901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 262316010902 UGMP family protein; Validated; Region: PRK09604 262316010903 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 262316010904 oligomerisation interface [polypeptide binding]; other site 262316010905 mobile loop; other site 262316010906 roof hairpin; other site 262316010907 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 262316010908 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 262316010909 ring oligomerisation interface [polypeptide binding]; other site 262316010910 ATP/Mg binding site [chemical binding]; other site 262316010911 stacking interactions; other site 262316010912 hinge regions; other site 262316010913 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 262316010914 dimerization interface [polypeptide binding]; other site 262316010915 cyclase homology domain; Region: CHD; cd07302 262316010916 nucleotidyl binding site; other site 262316010917 metal binding site [ion binding]; metal-binding site 262316010918 dimer interface [polypeptide binding]; other site 262316010919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 262316010920 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 262316010921 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 262316010922 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 262316010923 hypothetical protein; Provisional; Region: PRK06185 262316010924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010925 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 262316010926 E-class dimer interface [polypeptide binding]; other site 262316010927 P-class dimer interface [polypeptide binding]; other site 262316010928 active site 262316010929 Cu2+ binding site [ion binding]; other site 262316010930 Zn2+ binding site [ion binding]; other site 262316010931 Transcription factor WhiB; Region: Whib; pfam02467 262316010932 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 262316010933 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316010934 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 262316010935 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 262316010936 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 262316010937 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 262316010938 active site 262316010939 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 262316010940 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 262316010941 phosphate binding site [ion binding]; other site 262316010942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010943 hypothetical protein; Provisional; Region: PRK07233 262316010944 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316010945 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316010946 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316010947 classical (c) SDRs; Region: SDR_c; cd05233 262316010948 NAD(P) binding site [chemical binding]; other site 262316010949 active site 262316010950 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 262316010951 metal-binding site [ion binding] 262316010952 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 262316010953 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 262316010954 metal-binding site [ion binding] 262316010955 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262316010956 Predicted esterase [General function prediction only]; Region: COG0627 262316010957 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316010958 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 262316010959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316010960 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 262316010961 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 262316010962 Secretory lipase; Region: LIP; pfam03583 262316010963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 262316010964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010966 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316010967 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316010968 classical (c) SDRs; Region: SDR_c; cd05233 262316010969 NAD(P) binding site [chemical binding]; other site 262316010970 active site 262316010971 acyl-CoA synthetase; Provisional; Region: PRK13388 262316010972 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316010973 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 262316010974 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 262316010975 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 262316010976 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316010977 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 262316010978 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316010979 active site 262316010980 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316010981 CoA-transferase family III; Region: CoA_transf_3; cl00778 262316010982 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316010983 Transcriptional regulators [Transcription]; Region: PurR; COG1609 262316010984 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 262316010985 DNA binding site [nucleotide binding] 262316010986 domain linker motif; other site 262316010987 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 262316010988 dimerization interface [polypeptide binding]; other site 262316010989 ligand binding site [chemical binding]; other site 262316010990 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 262316010991 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316010992 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 262316010993 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 262316010994 active site 262316010995 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316010996 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316010997 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316010998 active site 262316010999 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316011000 active site 262316011001 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 262316011002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316011003 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 262316011004 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 262316011005 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 262316011006 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 262316011007 putative active site [active] 262316011008 catalytic residue [active] 262316011009 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316011010 anti sigma factor interaction site; other site 262316011011 regulatory phosphorylation site [posttranslational modification]; other site 262316011012 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 262316011013 putative active site [active] 262316011014 ATP binding site [chemical binding]; other site 262316011015 putative substrate binding site [chemical binding]; other site 262316011016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316011017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316011018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316011019 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316011020 active site 262316011021 ATP binding site [chemical binding]; other site 262316011022 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316011023 substrate binding site [chemical binding]; other site 262316011024 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 262316011025 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316011026 active site 262316011027 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 262316011028 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316011029 [2Fe-2S] cluster binding site [ion binding]; other site 262316011030 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 262316011031 putative alpha subunit interface [polypeptide binding]; other site 262316011032 putative active site [active] 262316011033 putative substrate binding site [chemical binding]; other site 262316011034 Fe binding site [ion binding]; other site 262316011035 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262316011036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 262316011037 active site 262316011038 phosphorylation site [posttranslational modification] 262316011039 intermolecular recognition site; other site 262316011040 dimerization interface [polypeptide binding]; other site 262316011041 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 262316011042 DNA binding residues [nucleotide binding] 262316011043 dimerization interface [polypeptide binding]; other site 262316011044 Histidine kinase; Region: HisKA_3; pfam07730 262316011045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316011046 Transport protein; Region: actII; TIGR00833 262316011047 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 262316011048 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316011049 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 262316011050 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316011051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 262316011052 Protein of unknown function (DUF690); Region: DUF690; cl04939 262316011053 Protein of unknown function (DUF690); Region: DUF690; cl04939 262316011054 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 262316011055 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 262316011056 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 262316011057 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 262316011058 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 262316011059 active site 262316011060 NTP binding site [chemical binding]; other site 262316011061 metal binding triad [ion binding]; metal-binding site 262316011062 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 262316011063 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262316011064 Zn2+ binding site [ion binding]; other site 262316011065 Mg2+ binding site [ion binding]; other site 262316011066 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 262316011067 active site 262316011068 Ap6A binding site [chemical binding]; other site 262316011069 nudix motif; other site 262316011070 metal binding site [ion binding]; metal-binding site 262316011071 MviN-like protein; Region: MVIN; pfam03023 262316011072 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 262316011073 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316011074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 262316011075 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 262316011076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316011077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316011078 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262316011079 catalytic residues [active] 262316011080 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 262316011081 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 262316011082 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 262316011083 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 262316011084 active site 262316011085 metal binding site [ion binding]; metal-binding site 262316011086 ParB-like partition proteins; Region: parB_part; TIGR00180 262316011087 ParB-like nuclease domain; Region: ParBc; cl02129 262316011088 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 262316011089 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 262316011090 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 262316011091 Magnesium ion binding site [ion binding]; other site 262316011092 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 262316011093 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 262316011094 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 262316011095 G-X-X-G motif; other site 262316011096 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 262316011097 RxxxH motif; other site 262316011098 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 262316011099 Domain of unknown function DUF37; Region: DUF37; cl00506 262316011100 Ribonuclease P; Region: Ribonuclease_P; cl00457 262316011101 Ribosomal protein L34; Region: Ribosomal_L34; cl00370