-- dump date 20120504_152753 -- class Genbank::misc_feature -- table misc_feature_note -- id note 233413000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 233413000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413000003 Walker A motif; other site 233413000004 ATP binding site [chemical binding]; other site 233413000005 Walker B motif; other site 233413000006 arginine finger; other site 233413000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 233413000008 DnaA box-binding interface [nucleotide binding]; other site 233413000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 233413000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 233413000011 putative DNA binding surface [nucleotide binding]; other site 233413000012 dimer interface [polypeptide binding]; other site 233413000013 beta-clamp/clamp loader binding surface; other site 233413000014 beta-clamp/translesion DNA polymerase binding surface; other site 233413000015 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 233413000016 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 233413000017 Walker A/P-loop; other site 233413000018 ATP binding site [chemical binding]; other site 233413000019 Q-loop/lid; other site 233413000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000021 ABC transporter signature motif; other site 233413000022 Walker B; other site 233413000023 D-loop; other site 233413000024 H-loop/switch region; other site 233413000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 233413000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 233413000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 233413000028 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 233413000029 anchoring element; other site 233413000030 dimer interface [polypeptide binding]; other site 233413000031 ATP binding site [chemical binding]; other site 233413000032 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 233413000033 active site 233413000034 putative metal-binding site [ion binding]; other site 233413000035 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 233413000036 DNA gyrase subunit A; Validated; Region: PRK05560 233413000037 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 233413000038 CAP-like domain; other site 233413000039 active site 233413000040 primary dimer interface [polypeptide binding]; other site 233413000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 233413000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 233413000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 233413000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 233413000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 233413000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 233413000047 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 233413000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 233413000049 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 233413000050 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 233413000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 233413000052 active site 233413000053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 233413000054 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 233413000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 233413000056 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 233413000057 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 233413000058 Glutamine amidotransferase class-I; Region: GATase; pfam00117 233413000059 glutamine binding [chemical binding]; other site 233413000060 catalytic triad [active] 233413000061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 233413000062 Catalytic domain of Protein Kinases; Region: PKc; cd00180 233413000063 active site 233413000064 ATP binding site [chemical binding]; other site 233413000065 substrate binding site [chemical binding]; other site 233413000066 activation loop (A-loop); other site 233413000067 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 233413000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 233413000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 233413000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 233413000071 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 233413000072 Catalytic domain of Protein Kinases; Region: PKc; cd00180 233413000073 active site 233413000074 ATP binding site [chemical binding]; other site 233413000075 substrate binding site [chemical binding]; other site 233413000076 activation loop (A-loop); other site 233413000077 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413000078 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 233413000079 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 233413000080 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 233413000081 active site 233413000082 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 233413000083 phosphopeptide binding site; other site 233413000084 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 233413000085 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 233413000086 phosphopeptide binding site; other site 233413000087 Nitronate monooxygenase; Region: NMO; pfam03060 233413000088 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 233413000089 FMN binding site [chemical binding]; other site 233413000090 substrate binding site [chemical binding]; other site 233413000091 putative catalytic residue [active] 233413000092 Transcription factor WhiB; Region: Whib; pfam02467 233413000093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 233413000094 non-specific DNA binding site [nucleotide binding]; other site 233413000095 salt bridge; other site 233413000096 sequence-specific DNA binding site [nucleotide binding]; other site 233413000097 Mb0025, -, len: 89 aa. Equivalent to 3' end of Rv0024, len: 281 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 89 aa overlap). secreted protein, p60 homologue, similar in part to others and relatives proteins e.g. P60_LISIV|Q01837 protein p60 precursor (invasion-associated protein) from Listeria ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08, (37.0% identity in 100 aa overlap); CAB92656.1|AL356832 NPL/P60 family secreted protein from Streptomyces coelicolor (347 aa) ; etc. Similar to Mycobacterium tuberculosis proteins Rv1477, Rv1478, Rv1566c, Rv2190c. And several homologues in Streptomyces coelicolor e.g. AL049497|SC6G10_8|T35517 probable secreted protein (338 aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / LISTERIA P60 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0024 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0024 into 2 parts, Mb0024 and Mb0025.; SECRETED PROTEIN P60-RELATED PROTEIN [SECOND PART] 233413000098 Biofilm regulator BssS; Region: BssS; pfam10774 233413000099 Biofilm regulator BssS; Region: BssS; pfam10774 233413000100 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413000101 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 233413000102 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 233413000103 FemAB family; Region: FemAB; cl11444 233413000104 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 233413000105 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 233413000106 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413000107 catalytic residue [active] 233413000108 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413000109 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 233413000110 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 233413000111 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413000112 TIGR03084 family protein; Region: TIGR03084 233413000113 DinB superfamily; Region: DinB_2; cl00986 233413000114 Wyosine base formation; Region: Wyosine_form; pfam08608 233413000115 H+ Antiporter protein; Region: 2A0121; TIGR00900 233413000116 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 233413000117 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 233413000118 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 233413000119 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 233413000120 active site 233413000121 HIGH motif; other site 233413000122 nucleotide binding site [chemical binding]; other site 233413000123 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 233413000124 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 233413000125 active site 233413000126 KMSKS motif; other site 233413000127 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 233413000128 tRNA binding surface [nucleotide binding]; other site 233413000129 Helix-turn-helix domains; Region: HTH; cl00088 233413000130 Transcriptional regulators [Transcription]; Region: GntR; COG1802 233413000131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 233413000132 DNA-binding site [nucleotide binding]; DNA binding site 233413000133 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 233413000134 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413000135 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 233413000136 Helix-turn-helix domains; Region: HTH; cl00088 233413000137 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 233413000138 Transglycosylase; Region: Transgly; cl07896 233413000139 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 233413000140 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413000141 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 233413000142 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 233413000143 conserved cys residue [active] 233413000144 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 233413000145 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 233413000146 dimer interface [polypeptide binding]; other site 233413000147 ssDNA binding site [nucleotide binding]; other site 233413000148 tetramer (dimer of dimers) interface [polypeptide binding]; other site 233413000149 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 233413000150 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 233413000151 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 233413000152 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 233413000153 replicative DNA helicase; Validated; Region: PRK07773 233413000154 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 233413000155 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 233413000156 Walker A motif; other site 233413000157 ATP binding site [chemical binding]; other site 233413000158 Walker B motif; other site 233413000159 DNA binding loops [nucleotide binding] 233413000160 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 233413000161 thioester formation/cholesterol transfer; other site 233413000162 protein-splicing catalytic site; other site 233413000163 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 233413000164 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000165 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 233413000166 ADP-ribose binding site [chemical binding]; other site 233413000167 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 233413000168 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 233413000169 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 233413000170 FAD binding domain; Region: FAD_binding_4; pfam01565 233413000171 Berberine and berberine like; Region: BBE; pfam08031 233413000172 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 233413000173 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 233413000174 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 233413000175 homotetrameric interface [polypeptide binding]; other site 233413000176 putative active site [active] 233413000177 metal binding site [ion binding]; metal-binding site 233413000178 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 233413000179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413000180 Helix-turn-helix domains; Region: HTH; cl00088 233413000181 short chain dehydrogenase; Provisional; Region: PRK06197 233413000182 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 233413000183 putative NAD(P) binding site [chemical binding]; other site 233413000184 active site 233413000185 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 233413000186 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 233413000187 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 233413000188 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 233413000189 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 233413000190 dimer interface [polypeptide binding]; other site 233413000191 glycine-pyridoxal phosphate binding site [chemical binding]; other site 233413000192 active site 233413000193 folate binding site [chemical binding]; other site 233413000194 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 233413000195 putative NTP binding site [chemical binding]; other site 233413000196 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 233413000197 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 233413000198 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 233413000199 Walker A/P-loop; other site 233413000200 ATP binding site [chemical binding]; other site 233413000201 Q-loop/lid; other site 233413000202 ABC transporter signature motif; other site 233413000203 Walker B; other site 233413000204 D-loop; other site 233413000205 H-loop/switch region; other site 233413000206 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 233413000207 Mb0075, -, len: 70 aa. Equivalent to 3' end of Rv0073, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 70 aa overlap). Probable glutamine-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (231 aa); T34822 ABC-transporter ATP binding protein from Streptomyces coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC transporter ATP-binding protein from Escherichia coli (648 aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity in 233 aa overlap); etc. Also highly similar to Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter ATP-binding protein from Mycobacterium tuberculosis (330 aa), FASTA scores: E(): 0, (83.3% identity in 330 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and PS00889 Cyclic nucleotide-binding domain signature 2. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that supposed act with near ORF Rv0072|MTV030.16 transmembrane ABC-transporter. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075.;PROBABLE GLUTAMINE-TRANSPORT PROTEIN ABC TRANSPORTER GLNQ 233413000208 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 233413000209 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 233413000210 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 233413000211 active site 233413000212 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 233413000213 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 233413000214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413000215 homodimer interface [polypeptide binding]; other site 233413000216 catalytic residue [active] 233413000217 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413000218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413000219 Helix-turn-helix domains; Region: HTH; cl00088 233413000220 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 233413000221 Helix-turn-helix domains; Region: HTH; cl00088 233413000222 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 233413000223 hydrogenase 4 subunit B; Validated; Region: PRK06521 233413000224 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 233413000225 NADH dehydrogenase; Region: NADHdh; cl00469 233413000226 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 233413000227 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 233413000228 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 233413000229 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15698 233413000230 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 233413000231 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 233413000232 putative hydrophobic ligand binding site [chemical binding]; other site 233413000233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413000234 S-adenosylmethionine binding site [chemical binding]; other site 233413000235 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 233413000236 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 233413000237 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 233413000238 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 233413000239 metal-binding site [ion binding] 233413000240 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 233413000241 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413000242 Anti-sigma-K factor rskA; Region: RskA; cl15366 233413000243 Domain of unknown function DUF222; Region: DUF222; pfam02720 233413000244 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413000245 active site 233413000246 Domain of unknown function (DUF222); Region: DUF222; pfam02720 233413000247 PPE family; Region: PPE; pfam00823 233413000248 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 233413000249 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 233413000250 FcoT-like thioesterase domain; Region: FcoT; pfam10862 233413000251 acyl-CoA synthetase; Validated; Region: PRK05857 233413000252 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413000253 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413000254 peptide synthase; Provisional; Region: PRK12316 233413000255 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413000256 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413000257 peptide synthase; Provisional; Region: PRK12467 233413000258 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413000259 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413000260 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 233413000261 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 233413000262 putative NAD(P) binding site [chemical binding]; other site 233413000263 active site 233413000264 putative substrate binding site [chemical binding]; other site 233413000265 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 233413000266 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 233413000267 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 233413000268 metal-binding site [ion binding] 233413000269 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 233413000270 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413000271 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 233413000272 ligand binding site [chemical binding]; other site 233413000273 flexible hinge region; other site 233413000274 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 233413000275 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 233413000276 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 233413000277 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 233413000278 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 233413000279 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413000280 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 233413000281 PE family; Region: PE; pfam00934 233413000282 Rhomboid family; Region: Rhomboid; cl11446 233413000283 OpgC protein; Region: OpgC_C; cl00792 233413000284 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 233413000285 active site 233413000286 catalytic triad [active] 233413000287 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 233413000288 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 233413000289 NADP-binding site; other site 233413000290 homotetramer interface [polypeptide binding]; other site 233413000291 substrate binding site [chemical binding]; other site 233413000292 homodimer interface [polypeptide binding]; other site 233413000293 active site 233413000294 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 233413000295 dimer interface [polypeptide binding]; other site 233413000296 active site 233413000297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 233413000298 active site 233413000299 motif I; other site 233413000300 motif II; other site 233413000301 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 233413000302 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 233413000303 Transcriptional regulator [Transcription]; Region: LysR; COG0583 233413000304 Helix-turn-helix domains; Region: HTH; cl00088 233413000305 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 233413000306 dimerization interface [polypeptide binding]; other site 233413000307 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 233413000308 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 233413000309 PYR/PP interface [polypeptide binding]; other site 233413000310 dimer interface [polypeptide binding]; other site 233413000311 TPP binding site [chemical binding]; other site 233413000312 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 233413000313 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 233413000314 TPP-binding site; other site 233413000315 dimer interface [polypeptide binding]; other site 233413000316 acyl-CoA synthetase; Validated; Region: PRK05852 233413000317 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413000318 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413000319 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000320 G4 box; other site 233413000321 G5 box; other site 233413000322 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 233413000323 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 233413000324 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 233413000325 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000326 G1 box; other site 233413000327 GTP/Mg2+ binding site [chemical binding]; other site 233413000328 G2 box; other site 233413000329 Switch I region; other site 233413000330 G3 box; other site 233413000331 Switch II region; other site 233413000332 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 233413000333 PE family; Region: PE; pfam00934 233413000334 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 233413000335 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 233413000336 trehalose synthase; Region: treS_nterm; TIGR02456 233413000337 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 233413000338 active site 233413000339 catalytic site [active] 233413000340 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 233413000341 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 233413000342 Predicted esterase [General function prediction only]; Region: COG0627 233413000343 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 233413000344 putative active site [active] 233413000345 putative catalytic site [active] 233413000346 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413000347 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413000348 active site 233413000349 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 233413000350 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 233413000351 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 233413000352 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 233413000353 Mb0139-1, -, len: 128 aa. Pseudogene part1 of Rv0134/ephF 233413000354 Mb0139-2, -, len: 36 aa. Pseudogene part2 of Rv0134/ephF 233413000355 Mb0139-3, -, len: 80 aa. Pseudogene part3 of Rv0134/ephF 233413000356 Mb0139-4, -, len: 55 aa. Pseudogene part4 of Rv0134/ephF. 233413000357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413000358 Helix-turn-helix domains; Region: HTH; cl00088 233413000359 Cytochrome P450; Region: p450; cl12078 233413000360 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 233413000361 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 233413000362 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 233413000363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413000364 NAD(P) binding site [chemical binding]; other site 233413000365 active site 233413000366 Domain of unknown function (DUF427); Region: DUF427; cl00998 233413000367 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 233413000368 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 233413000369 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 233413000370 minor groove reading motif; other site 233413000371 helix-hairpin-helix signature motif; other site 233413000372 active site 233413000373 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 233413000374 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 233413000375 Cl- selectivity filter; other site 233413000376 Cl- binding residues [ion binding]; other site 233413000377 pore gating glutamate residue; other site 233413000378 dimer interface [polypeptide binding]; other site 233413000379 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413000380 Helix-turn-helix domains; Region: HTH; cl00088 233413000381 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413000382 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413000383 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 233413000384 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 233413000385 NAD(P) binding site [chemical binding]; other site 233413000386 catalytic residues [active] 233413000387 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 233413000388 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 233413000389 NAD binding site [chemical binding]; other site 233413000390 homodimer interface [polypeptide binding]; other site 233413000391 active site 233413000392 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 233413000393 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 233413000394 NAD(P) binding site [chemical binding]; other site 233413000395 PE family; Region: PE; pfam00934 233413000396 Cutinase; Region: Cutinase; cl15711 233413000397 Cutinase; Region: Cutinase; cl15711 233413000398 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 233413000399 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 233413000400 FAD binding site [chemical binding]; other site 233413000401 substrate binding site [chemical binding]; other site 233413000402 catalytic base [active] 233413000403 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 233413000404 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 233413000405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413000406 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 233413000407 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 233413000408 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 233413000409 Helix-turn-helix domains; Region: HTH; cl00088 233413000410 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 233413000411 PE family; Region: PE; pfam00934 233413000412 Cutinase; Region: Cutinase; cl15711 233413000413 PE family; Region: PE; pfam00934 233413000414 Cutinase; Region: Cutinase; cl15711 233413000415 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 233413000416 FAD binding domain; Region: FAD_binding_4; pfam01565 233413000417 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 233413000418 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 233413000419 NAD(P) binding site [chemical binding]; other site 233413000420 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 233413000421 active site 233413000422 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 233413000423 putative hydrophobic ligand binding site [chemical binding]; other site 233413000424 Transcriptional regulators [Transcription]; Region: GntR; COG1802 233413000425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 233413000426 DNA-binding site [nucleotide binding]; DNA binding site 233413000427 FCD domain; Region: FCD; cl11656 233413000428 Mb0171c, -, len: 59 aa. Equivalent to 3' end of Rv0165c, len: 264 aa, from Mycobacterium tuberculosis strain H37Rv, (96.5% identity in 57 aa overlap). Possible transcriptional regulator, GntR family, showing some similarity to several e.g. NTRA_CHELE|P54988 nta operon transcriptional regulator (231 aa), FASTA scores: opt: 154, E(): 0.00058, (32.0% identity in 125 aa overlap); P46833|GNTR_BACLI GLUCONATE OPERON TRANSCRIPTIONAL REPRESSOR from Bacillus licheniformis (243 aa); GNTR_BACSU GLUCONATE OPERON REPRESSOR from Bacillus subtilis (243 aa). Also similar to Rv0043c from Mycobacterium tuberculosis. SEEMS TO BELONG TO THE GNTR FAMILY OF TRANSCRIPTIONAL REGULATORS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp insertion (*-cc) leads to a product with a different COOH part. Mb0171c corresponds to the remnant COOH part of Rv0165c.;POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY) 233413000429 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 233413000430 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413000431 Domain of unknown function DUF140; Region: DUF140; cl00510 233413000432 Domain of unknown function DUF140; Region: DUF140; cl00510 233413000433 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413000434 mce related protein; Region: MCE; cl15431 233413000435 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 233413000436 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413000437 mce related protein; Region: MCE; cl15431 233413000438 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 233413000439 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413000440 mce related protein; Region: MCE; cl15431 233413000441 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413000442 mce related protein; Region: MCE; cl15431 233413000443 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413000444 mce related protein; Region: MCE; cl15431 233413000445 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413000446 mce related protein; Region: MCE; cl15431 233413000447 RDD family; Region: RDD; cl00746 233413000448 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 233413000449 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 233413000450 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 233413000451 ABC-2 type transporter; Region: ABC2_membrane; cl11417 233413000452 Pirin-related protein [General function prediction only]; Region: COG1741 233413000453 Cupin domain; Region: Cupin_2; cl09118 233413000454 RNA polymerase factor sigma-70; Validated; Region: PRK08241 233413000455 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 233413000456 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 233413000457 DNA binding residues [nucleotide binding] 233413000458 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 233413000459 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 233413000460 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413000461 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 233413000462 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 233413000463 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 233413000464 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 233413000465 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 233413000466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413000467 S-adenosylmethionine binding site [chemical binding]; other site 233413000468 SPW repeat; Region: SPW; pfam03779 233413000469 SPW repeat; Region: SPW; pfam03779 233413000470 Dehydratase family; Region: ILVD_EDD; cl00340 233413000471 6-phosphogluconate dehydratase; Region: edd; TIGR01196 233413000472 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 233413000473 putative homotetramer interface [polypeptide binding]; other site 233413000474 putative homodimer interface [polypeptide binding]; other site 233413000475 putative allosteric switch controlling residues; other site 233413000476 putative metal binding site [ion binding]; other site 233413000477 putative homodimer-homodimer interface [polypeptide binding]; other site 233413000478 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 233413000479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413000480 putative substrate translocation pore; other site 233413000481 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 233413000482 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 233413000483 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 233413000484 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000485 Walker A/P-loop; other site 233413000486 ATP binding site [chemical binding]; other site 233413000487 Q-loop/lid; other site 233413000488 ABC transporter signature motif; other site 233413000489 Walker B; other site 233413000490 D-loop; other site 233413000491 H-loop/switch region; other site 233413000492 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 233413000493 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000494 Walker A/P-loop; other site 233413000495 ATP binding site [chemical binding]; other site 233413000496 Q-loop/lid; other site 233413000497 ABC transporter signature motif; other site 233413000498 Walker B; other site 233413000499 D-loop; other site 233413000500 H-loop/switch region; other site 233413000501 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 233413000502 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 233413000503 dimerization interface [polypeptide binding]; other site 233413000504 DNA binding residues [nucleotide binding] 233413000505 Helix-turn-helix domains; Region: HTH; cl00088 233413000506 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 233413000507 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 233413000508 putative [Fe4-S4] binding site [ion binding]; other site 233413000509 putative molybdopterin cofactor binding site [chemical binding]; other site 233413000510 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 233413000511 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 233413000512 putative molybdopterin cofactor binding site; other site 233413000513 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 233413000514 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 233413000515 active site 233413000516 Zn binding site [ion binding]; other site 233413000517 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 233413000518 Protein export membrane protein; Region: SecD_SecF; cl14618 233413000519 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 233413000520 Domain of unknown function DUF20; Region: UPF0118; cl00465 233413000521 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 233413000522 LabA_like proteins; Region: LabA_like; cd06167 233413000523 putative metal binding site [ion binding]; other site 233413000524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413000525 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 233413000526 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 233413000527 active site 233413000528 substrate-binding site [chemical binding]; other site 233413000529 metal-binding site [ion binding] 233413000530 GTP binding site [chemical binding]; other site 233413000531 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 233413000532 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 233413000533 active site 233413000534 (T/H)XGH motif; other site 233413000535 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; cl01238 233413000536 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 233413000537 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 233413000538 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413000539 FeS/SAM binding site; other site 233413000540 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 233413000541 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413000542 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413000543 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413000544 active site 233413000545 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 233413000546 putative active site [active] 233413000547 putative catalytic site [active] 233413000548 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 233413000549 active site 2 [active] 233413000550 active site 1 [active] 233413000551 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413000552 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 233413000553 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 233413000554 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 233413000555 Moco binding site; other site 233413000556 metal coordination site [ion binding]; other site 233413000557 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413000558 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 233413000559 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413000560 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413000561 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 233413000562 NAD(P) binding site [chemical binding]; other site 233413000563 catalytic residues [active] 233413000564 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 233413000565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413000566 S-adenosylmethionine binding site [chemical binding]; other site 233413000567 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 233413000568 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 233413000569 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 233413000570 OpgC protein; Region: OpgC_C; cl00792 233413000571 Acyltransferase family; Region: Acyl_transf_3; pfam01757 233413000572 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 233413000573 putative active site [active] 233413000574 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 233413000575 active site 233413000576 substrate binding pocket [chemical binding]; other site 233413000577 homodimer interaction site [polypeptide binding]; other site 233413000578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413000579 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 233413000580 active site 233413000581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413000582 Helix-turn-helix domains; Region: HTH; cl00088 233413000583 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 233413000584 active site 233413000585 diiron metal binding site [ion binding]; other site 233413000586 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 233413000587 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 233413000588 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 233413000589 NAD(P) binding site [chemical binding]; other site 233413000590 catalytic residues [active] 233413000591 Protein of unknown function (DUF1222); Region: DUF1222; pfam06762 233413000592 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 233413000593 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 233413000594 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 233413000595 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413000596 Helix-turn-helix domains; Region: HTH; cl00088 233413000597 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413000598 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 233413000599 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 233413000600 active site 2 [active] 233413000601 active site 1 [active] 233413000602 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 233413000603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413000604 NAD(P) binding site [chemical binding]; other site 233413000605 active site 233413000606 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 233413000607 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 233413000608 dimer interface [polypeptide binding]; other site 233413000609 active site 233413000610 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 233413000611 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 233413000612 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 233413000613 FAD binding site [chemical binding]; other site 233413000614 substrate binding site [chemical binding]; other site 233413000615 catalytic residues [active] 233413000616 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 233413000617 Flavin Reductases; Region: FlaRed; cl00801 233413000618 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 233413000619 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 233413000620 catalytic loop [active] 233413000621 iron binding site [ion binding]; other site 233413000622 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 233413000623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413000624 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 233413000625 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 233413000626 putative dimer interface [polypeptide binding]; other site 233413000627 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 233413000628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413000629 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 233413000630 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 233413000631 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 233413000632 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 233413000633 homotrimer interface [polypeptide binding]; other site 233413000634 Walker A motif; other site 233413000635 GTP binding site [chemical binding]; other site 233413000636 Walker B motif; other site 233413000637 cobyric acid synthase; Provisional; Region: PRK00784 233413000638 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000639 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000640 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 233413000641 catalytic triad [active] 233413000642 PPE family; Region: PPE; pfam00823 233413000643 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 233413000644 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 233413000645 putative active site [active] 233413000646 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 233413000647 putative active site [active] 233413000648 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 233413000649 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 233413000650 active site 233413000651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 233413000652 DNA binding site [nucleotide binding] 233413000653 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 233413000654 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 233413000655 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 233413000656 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 233413000657 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 233413000658 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 233413000659 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 233413000660 intersubunit interface [polypeptide binding]; other site 233413000661 5-oxoprolinase; Region: PLN02666 233413000662 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 233413000663 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 233413000664 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 233413000665 Phd_YefM; Region: PhdYeFM; cl09153 233413000666 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 233413000667 nucleotide binding site [chemical binding]; other site 233413000668 acyl-CoA synthetase; Validated; Region: PRK07788 233413000669 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413000670 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413000671 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413000672 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 233413000673 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413000674 FAD binding site [chemical binding]; other site 233413000675 substrate binding site [chemical binding]; other site 233413000676 catalytic base [active] 233413000677 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 233413000678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413000679 Helix-turn-helix domains; Region: HTH; cl00088 233413000680 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 233413000681 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 233413000682 Zn binding site [ion binding]; other site 233413000683 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 233413000684 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413000685 Mb0284c, PE_PGRS3b, len: 80 aa. Equivalent to 3' end of Rv0278c, len: 957 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 79 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0, (67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis, a 2780 bp insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (t-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b.;PE-PGRS FAMILY PROTEIN [SECOND PART] 233413000686 PE family; Region: PE; pfam00934 233413000687 PE family; Region: PE; pfam00934 233413000688 PE family; Region: PE; pfam00934 233413000689 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 233413000690 PPE family; Region: PPE; pfam00823 233413000691 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 233413000692 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413000693 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 233413000694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413000695 Walker A motif; other site 233413000696 ATP binding site [chemical binding]; other site 233413000697 Walker B motif; other site 233413000698 arginine finger; other site 233413000699 Protein of unknown function (DUF690); Region: DUF690; cl04939 233413000700 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 233413000701 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000702 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 233413000703 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000704 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000705 PPE family; Region: PPE; pfam00823 233413000706 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413000707 EspG family; Region: ESX-1_EspG; pfam14011 233413000708 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 233413000709 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 233413000710 active site 233413000711 catalytic residues [active] 233413000712 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 233413000713 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413000714 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413000715 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 233413000716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413000717 S-adenosylmethionine binding site [chemical binding]; other site 233413000718 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 233413000719 Sulfatase; Region: Sulfatase; cl10460 233413000720 hypothetical protein; Region: PHA01748 233413000721 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 233413000722 putative active site [active] 233413000723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413000724 Helix-turn-helix domains; Region: HTH; cl00088 233413000725 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 233413000726 short chain dehydrogenase; Provisional; Region: PRK06197 233413000727 putative NAD(P) binding site [chemical binding]; other site 233413000728 active site 233413000729 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000730 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000731 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000732 PPE family; Region: PPE; pfam00823 233413000733 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000734 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000735 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000736 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000737 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000738 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000739 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000740 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000741 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 233413000742 putative FMN binding site [chemical binding]; other site 233413000743 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 233413000744 active site 233413000745 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 233413000746 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 233413000747 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 233413000748 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 233413000749 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 233413000750 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 233413000751 active site 233413000752 catalytic residues [active] 233413000753 Muconolactone delta-isomerase; Region: MIase; cl01992 233413000754 Muconolactone delta-isomerase; Region: MIase; cl01992 233413000755 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 233413000756 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 233413000757 putative active site [active] 233413000758 catalytic site [active] 233413000759 putative metal binding site [ion binding]; other site 233413000760 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 233413000761 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 233413000762 putative substrate binding pocket [chemical binding]; other site 233413000763 AC domain interface; other site 233413000764 catalytic triad [active] 233413000765 AB domain interface; other site 233413000766 interchain disulfide; other site 233413000767 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 233413000768 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 233413000769 trimer interface [polypeptide binding]; other site 233413000770 active site 233413000771 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 233413000772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413000773 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 233413000774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413000775 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 233413000776 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 233413000777 dimerization interface [polypeptide binding]; other site 233413000778 putative DNA binding site [nucleotide binding]; other site 233413000779 putative Zn2+ binding site [ion binding]; other site 233413000780 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 233413000781 active site residue [active] 233413000782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413000783 S-adenosylmethionine binding site [chemical binding]; other site 233413000784 Cytochrome P450; Region: p450; cl12078 233413000785 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 233413000786 Helix-turn-helix domains; Region: HTH; cl00088 233413000787 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 233413000788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413000789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413000790 Helix-turn-helix domains; Region: HTH; cl00088 233413000791 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 233413000792 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 233413000793 DinB superfamily; Region: DinB_2; cl00986 233413000794 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 233413000795 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 233413000796 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 233413000797 substrate binding site; other site 233413000798 tetramer interface; other site 233413000799 PE family; Region: PE; pfam00934 233413000800 Domain of unknown function DUF222; Region: DUF222; pfam02720 233413000801 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413000802 active site 233413000803 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 233413000804 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 233413000805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413000806 homodimer interface [polypeptide binding]; other site 233413000807 catalytic residue [active] 233413000808 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 233413000809 4Fe-4S binding domain; Region: Fer4; cl02805 233413000810 Cysteine-rich domain; Region: CCG; pfam02754 233413000811 Cysteine-rich domain; Region: CCG; pfam02754 233413000812 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 233413000813 DNA binding residues [nucleotide binding] 233413000814 dimerization interface [polypeptide binding]; other site 233413000815 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 233413000816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000817 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000818 G3 box; other site 233413000819 Switch II region; other site 233413000820 GTP/Mg2+ binding site [chemical binding]; other site 233413000821 G4 box; other site 233413000822 G5 box; other site 233413000823 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 233413000824 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000825 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 233413000826 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 233413000827 Amino acid permease; Region: AA_permease; cl00524 233413000828 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 233413000829 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 233413000830 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 233413000831 dimer interface [polypeptide binding]; other site 233413000832 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 233413000833 chaperone protein DnaJ; Provisional; Region: PRK14279 233413000834 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 233413000835 HSP70 interaction site [polypeptide binding]; other site 233413000836 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 233413000837 Zn binding sites [ion binding]; other site 233413000838 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 233413000839 dimer interface [polypeptide binding]; other site 233413000840 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 233413000841 DNA binding residues [nucleotide binding] 233413000842 putative dimer interface [polypeptide binding]; other site 233413000843 PPE family; Region: PPE; pfam00823 233413000844 Sec24-related protein; Provisional; Region: PTZ00395 233413000845 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000846 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000847 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000848 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 233413000849 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000850 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 233413000851 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000852 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000853 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000854 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413000855 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 233413000856 CoenzymeA binding site [chemical binding]; other site 233413000857 subunit interaction site [polypeptide binding]; other site 233413000858 PHB binding site; other site 233413000859 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 233413000860 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 233413000861 GDP-binding site [chemical binding]; other site 233413000862 ACT binding site; other site 233413000863 IMP binding site; other site 233413000864 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 233413000865 active site 233413000866 putative substrate binding region [chemical binding]; other site 233413000867 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 233413000868 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 233413000869 MgtE intracellular N domain; Region: MgtE_N; cl15244 233413000870 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 233413000871 Divalent cation transporter; Region: MgtE; cl00786 233413000872 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 233413000873 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 233413000874 active site 233413000875 intersubunit interface [polypeptide binding]; other site 233413000876 zinc binding site [ion binding]; other site 233413000877 Na+ binding site [ion binding]; other site 233413000878 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 233413000879 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 233413000880 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 233413000881 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000882 AAA domain; Region: AAA_33; pfam13671 233413000883 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 233413000884 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 233413000885 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 233413000886 putative hydrophobic ligand binding site [chemical binding]; other site 233413000887 MoxR-like ATPases [General function prediction only]; Region: COG0714 233413000888 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 233413000889 Ligand binding site; other site 233413000890 metal-binding site 233413000891 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 233413000892 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 233413000893 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 233413000894 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 233413000895 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 233413000896 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 233413000897 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 233413000898 catalytic loop [active] 233413000899 iron binding site [ion binding]; other site 233413000900 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 233413000901 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 233413000902 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 233413000903 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 233413000904 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 233413000905 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 233413000906 XdhC Rossmann domain; Region: XdhC_C; pfam13478 233413000907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 233413000908 Helix-turn-helix domains; Region: HTH; cl00088 233413000909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 233413000910 Protein of unknown function (DUF1458); Region: DUF1458; cl01328 233413000911 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 233413000912 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 233413000913 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 233413000914 Clp amino terminal domain; Region: Clp_N; pfam02861 233413000915 Clp amino terminal domain; Region: Clp_N; pfam02861 233413000916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413000917 Walker A motif; other site 233413000918 ATP binding site [chemical binding]; other site 233413000919 Walker B motif; other site 233413000920 arginine finger; other site 233413000921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413000922 Walker A motif; other site 233413000923 ATP binding site [chemical binding]; other site 233413000924 Walker B motif; other site 233413000925 arginine finger; other site 233413000926 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 233413000927 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 233413000928 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 233413000929 heme-binding site [chemical binding]; other site 233413000930 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 233413000931 FAD binding pocket [chemical binding]; other site 233413000932 FAD binding motif [chemical binding]; other site 233413000933 phosphate binding motif [ion binding]; other site 233413000934 beta-alpha-beta structure motif; other site 233413000935 NAD binding pocket [chemical binding]; other site 233413000936 cyclase homology domain; Region: CHD; cd07302 233413000937 nucleotidyl binding site; other site 233413000938 metal binding site [ion binding]; metal-binding site 233413000939 dimer interface [polypeptide binding]; other site 233413000940 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000941 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 233413000942 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 233413000943 DNA binding residues [nucleotide binding] 233413000944 PPE family; Region: PPE; pfam00823 233413000945 phosphoribosylglycinamide formyltransferase 2; Region: purT; TIGR01142 233413000946 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 233413000947 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 233413000948 active site residue [active] 233413000949 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 233413000950 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 233413000951 homodimer interface [polypeptide binding]; other site 233413000952 substrate-cofactor binding pocket; other site 233413000953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413000954 catalytic residue [active] 233413000955 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 233413000956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413000957 Domain of unknown function DUF222; Region: DUF222; pfam02720 233413000958 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413000959 active site 233413000960 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 233413000961 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413000962 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 233413000963 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413000964 FAD binding site [chemical binding]; other site 233413000965 substrate binding pocket [chemical binding]; other site 233413000966 catalytic base [active] 233413000967 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 233413000968 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 233413000969 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 233413000970 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 233413000971 acyl-CoA synthetase; Validated; Region: PRK05850 233413000972 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413000973 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413000974 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413000975 active site 233413000976 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 233413000977 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 233413000978 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413000979 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413000980 Thioesterase; Region: PKS_TE; smart00824 233413000981 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413000982 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 233413000983 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 233413000984 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 233413000985 phosphate acetyltransferase; Reviewed; Region: PRK05632 233413000986 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413000987 DRTGG domain; Region: DRTGG; cl12147 233413000988 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 233413000989 Acetokinase family; Region: Acetate_kinase; cl01029 233413000990 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 233413000991 Catalytic domain of Protein Kinases; Region: PKc; cd00180 233413000992 active site 233413000993 ATP binding site [chemical binding]; other site 233413000994 substrate binding site [chemical binding]; other site 233413000995 activation loop (A-loop); other site 233413000996 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 233413000997 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 233413000998 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 233413000999 substrate binding pocket [chemical binding]; other site 233413001000 membrane-bound complex binding site; other site 233413001001 hinge residues; other site 233413001002 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 233413001003 nudix motif; other site 233413001004 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 233413001005 thiamine phosphate binding site [chemical binding]; other site 233413001006 active site 233413001007 pyrophosphate binding site [ion binding]; other site 233413001008 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 233413001009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001010 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 233413001011 thiS-thiF/thiG interaction site; other site 233413001012 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 233413001013 ThiS interaction site; other site 233413001014 putative active site [active] 233413001015 tetramer interface [polypeptide binding]; other site 233413001016 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 233413001017 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 233413001018 PA/protease or protease-like domain interface [polypeptide binding]; other site 233413001019 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 233413001020 active site 233413001021 metal binding site [ion binding]; metal-binding site 233413001022 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 233413001023 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 233413001024 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 233413001025 dimer interface [polypeptide binding]; other site 233413001026 substrate binding site [chemical binding]; other site 233413001027 ATP binding site [chemical binding]; other site 233413001028 ThiC family; Region: ThiC; cl08031 233413001029 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 233413001030 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 233413001031 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413001032 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 233413001033 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 233413001034 putative phosphate binding site [ion binding]; other site 233413001035 putative catalytic site [active] 233413001036 active site 233413001037 metal binding site A [ion binding]; metal-binding site 233413001038 DNA binding site [nucleotide binding] 233413001039 putative AP binding site [nucleotide binding]; other site 233413001040 putative metal binding site B [ion binding]; other site 233413001041 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 233413001042 active site 233413001043 catalytic residues [active] 233413001044 metal binding site [ion binding]; metal-binding site 233413001045 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 233413001046 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 233413001047 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 233413001048 E-class dimer interface [polypeptide binding]; other site 233413001049 P-class dimer interface [polypeptide binding]; other site 233413001050 active site 233413001051 Cu2+ binding site [ion binding]; other site 233413001052 Zn2+ binding site [ion binding]; other site 233413001053 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 233413001054 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 233413001055 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 233413001056 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 233413001057 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 233413001058 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413001059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413001060 Walker A motif; other site 233413001061 ATP binding site [chemical binding]; other site 233413001062 Walker B motif; other site 233413001063 arginine finger; other site 233413001064 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 233413001065 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 233413001066 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 233413001067 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 233413001068 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 233413001069 dimer interface [polypeptide binding]; other site 233413001070 putative functional site; other site 233413001071 putative MPT binding site; other site 233413001072 short chain dehydrogenase; Provisional; Region: PRK06197 233413001073 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 233413001074 putative NAD(P) binding site [chemical binding]; other site 233413001075 active site 233413001076 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 233413001077 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 233413001078 ring oligomerisation interface [polypeptide binding]; other site 233413001079 ATP/Mg binding site [chemical binding]; other site 233413001080 stacking interactions; other site 233413001081 hinge regions; other site 233413001082 PPE family; Region: PPE; pfam00823 233413001083 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 233413001084 DinB superfamily; Region: DinB_2; pfam12867 233413001085 Anti-sigma-K factor rskA; Region: RskA; cl15366 233413001086 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 233413001087 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 233413001088 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 233413001089 DNA binding residues [nucleotide binding] 233413001090 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 233413001091 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 233413001092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001093 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 233413001094 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 233413001095 Transport protein; Region: actII; TIGR00833 233413001096 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 233413001097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413001098 Helix-turn-helix domains; Region: HTH; cl00088 233413001099 PPE family; Region: PPE; pfam00823 233413001100 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 233413001101 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 233413001102 enoyl-CoA hydratase; Provisional; Region: PRK12478 233413001103 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413001104 substrate binding site [chemical binding]; other site 233413001105 oxyanion hole (OAH) forming residues; other site 233413001106 trimer interface [polypeptide binding]; other site 233413001107 PemK-like protein; Region: PemK; cl00995 233413001108 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 233413001109 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413001110 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 233413001111 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 233413001112 NAD(P) binding site [chemical binding]; other site 233413001113 catalytic residues [active] 233413001114 Protein of unknown function (DUF779); Region: DUF779; cl01432 233413001115 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 233413001116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001118 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 233413001119 Uncharacterized conserved protein [Function unknown]; Region: COG2128 233413001120 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 233413001121 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 233413001122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 233413001123 non-specific DNA binding site [nucleotide binding]; other site 233413001124 salt bridge; other site 233413001125 sequence-specific DNA binding site [nucleotide binding]; other site 233413001126 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 233413001127 Domain of unknown function (DUF955); Region: DUF955; cl01076 233413001128 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 233413001129 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 233413001130 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 233413001131 active site 233413001132 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 233413001133 active site 2 [active] 233413001134 active site 1 [active] 233413001135 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 233413001136 oligomerization interface [polypeptide binding]; other site 233413001137 active site 233413001138 metal binding site [ion binding]; metal-binding site 233413001139 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 233413001140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413001141 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 233413001142 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 233413001143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413001144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413001145 S-adenosylmethionine binding site [chemical binding]; other site 233413001146 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 233413001147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413001149 S-adenosylmethionine binding site [chemical binding]; other site 233413001150 UbiA prenyltransferase family; Region: UbiA; cl00337 233413001151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413001152 Helix-turn-helix domains; Region: HTH; cl00088 233413001153 Predicted membrane protein [Function unknown]; Region: COG2733 233413001154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 233413001155 non-specific DNA binding site [nucleotide binding]; other site 233413001156 salt bridge; other site 233413001157 sequence-specific DNA binding site [nucleotide binding]; other site 233413001158 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 233413001159 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 233413001160 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 233413001161 intersubunit interface [polypeptide binding]; other site 233413001162 active site 233413001163 catalytic residue [active] 233413001164 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 233413001165 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 233413001166 putative active site [active] 233413001167 catalytic triad [active] 233413001168 putative dimer interface [polypeptide binding]; other site 233413001169 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 233413001170 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 233413001171 FAD binding domain; Region: FAD_binding_4; pfam01565 233413001172 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 233413001173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 233413001174 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 233413001175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001176 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 233413001177 NAD(P) binding site [chemical binding]; other site 233413001178 active site 233413001179 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 233413001180 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 233413001181 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 233413001182 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 233413001183 putative ADP-binding pocket [chemical binding]; other site 233413001184 Protein of unknown function (DUF2596); Region: DUF2596; pfam10770 233413001185 LysE type translocator; Region: LysE; cl00565 233413001186 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 233413001187 catalytic core [active] 233413001188 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 233413001189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 233413001190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 233413001191 dimer interface [polypeptide binding]; other site 233413001192 phosphorylation site [posttranslational modification] 233413001193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 233413001194 ATP binding site [chemical binding]; other site 233413001195 Mg2+ binding site [ion binding]; other site 233413001196 G-X-G motif; other site 233413001197 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 233413001198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 233413001199 active site 233413001200 phosphorylation site [posttranslational modification] 233413001201 intermolecular recognition site; other site 233413001202 dimerization interface [polypeptide binding]; other site 233413001203 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 233413001204 DNA binding site [nucleotide binding] 233413001205 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 233413001206 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 233413001207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 233413001208 DNA-binding site [nucleotide binding]; DNA binding site 233413001209 FCD domain; Region: FCD; cl11656 233413001210 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 233413001211 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 233413001212 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 233413001213 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 233413001214 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 233413001215 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 233413001216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001218 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 233413001219 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 233413001220 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 233413001221 putative NAD(P) binding site [chemical binding]; other site 233413001222 active site 233413001223 putative substrate binding site [chemical binding]; other site 233413001224 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 233413001225 putative acyl-acceptor binding pocket; other site 233413001226 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 233413001227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413001228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413001229 S-adenosylmethionine binding site [chemical binding]; other site 233413001230 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 233413001231 active site 233413001232 catalytic site [active] 233413001233 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 233413001234 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413001235 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 233413001236 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 233413001237 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 233413001238 glutamyl-tRNA reductase; Region: hemA; TIGR01035 233413001239 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 233413001240 tRNA; other site 233413001241 putative tRNA binding site [nucleotide binding]; other site 233413001242 putative NADP binding site [chemical binding]; other site 233413001243 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 233413001244 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 233413001245 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 233413001246 domain interfaces; other site 233413001247 active site 233413001248 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 233413001249 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 233413001250 active site 233413001251 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 233413001252 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 233413001253 dimer interface [polypeptide binding]; other site 233413001254 active site 233413001255 Schiff base residues; other site 233413001256 Domain of unknown function DUF222; Region: DUF222; pfam02720 233413001257 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413001258 active site 233413001259 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 233413001260 anti sigma factor interaction site; other site 233413001261 regulatory phosphorylation site [posttranslational modification]; other site 233413001262 OpgC protein; Region: OpgC_C; cl00792 233413001263 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 233413001264 active site 233413001265 catalytic triad [active] 233413001266 oxyanion hole [active] 233413001267 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 233413001268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413001269 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 233413001270 Amino acid permease; Region: AA_permease; cl00524 233413001271 Domain of unknown function (DUF385); Region: DUF385; cl04387 233413001272 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 233413001273 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 233413001274 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413001275 catalytic residue [active] 233413001276 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 233413001277 catalytic core [active] 233413001278 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 233413001279 catalytic residues [active] 233413001280 LysE type translocator; Region: LysE; cl00565 233413001281 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 233413001282 ResB-like family; Region: ResB; pfam05140 233413001283 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 233413001284 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 233413001285 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 233413001286 P-loop; other site 233413001287 Magnesium ion binding site [ion binding]; other site 233413001288 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 233413001289 Mb0546, PE_PGRS6b, len: 75 aa. Equivalent to 3' end of Rv0532, len: 594 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 75 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0, (58.2% identity in 536 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PE_PGRS6 into 2 parts, PE_PGRS6a and PE_PGRS6b.;PE-PGRS FAMILY PROTEIN [SECOND PART] 233413001290 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 233413001291 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 233413001292 dimer interface [polypeptide binding]; other site 233413001293 active site 233413001294 CoA binding pocket [chemical binding]; other site 233413001295 UbiA prenyltransferase family; Region: UbiA; cl00337 233413001296 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 233413001297 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 233413001298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001299 NAD(P) binding site [chemical binding]; other site 233413001300 active site 233413001301 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 233413001302 Ligand binding site; other site 233413001303 Putative Catalytic site; other site 233413001304 DXD motif; other site 233413001305 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 233413001306 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 233413001307 AMP-binding enzyme; Region: AMP-binding; cl15778 233413001308 AMP-binding enzyme; Region: AMP-binding; cl15778 233413001309 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 233413001310 Phosphate transporter family; Region: PHO4; cl00396 233413001311 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 233413001312 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 233413001313 active site 233413001314 short chain dehydrogenase; Provisional; Region: PRK05866 233413001315 classical (c) SDRs; Region: SDR_c; cd05233 233413001316 NAD(P) binding site [chemical binding]; other site 233413001317 active site 233413001318 naphthoate synthase; Validated; Region: PRK08321 233413001319 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413001320 substrate binding site [chemical binding]; other site 233413001321 oxyanion hole (OAH) forming residues; other site 233413001322 trimer interface [polypeptide binding]; other site 233413001323 Mb0563c, -, len: 45 aa. Similar to 3' end of Rv0549c, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 45 aa overlap). Conserved hypothetical protein, similar to Rv0960, Rv0065, and Rv1720c from Mycobacterium tuberculosis. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv0549c into 2 parts, Mb0563c and Mb0564c.;CONSERVED HYPOTHETICAL PROTEIN [SECOND PART] 233413001324 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 233413001325 putative active site [active] 233413001326 homotetrameric interface [polypeptide binding]; other site 233413001327 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 233413001328 acyl-CoA synthetase; Validated; Region: PRK06188 233413001329 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413001330 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 233413001331 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 233413001332 active site 233413001333 O-succinylbenzoate synthase; Provisional; Region: PRK02901 233413001334 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 233413001335 active site 233413001336 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413001337 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 233413001338 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413001339 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 233413001340 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 233413001341 dimer interface [polypeptide binding]; other site 233413001342 tetramer interface [polypeptide binding]; other site 233413001343 PYR/PP interface [polypeptide binding]; other site 233413001344 TPP binding site [chemical binding]; other site 233413001345 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 233413001346 TPP-binding site; other site 233413001347 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 233413001348 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 233413001349 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 233413001350 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 233413001351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413001352 S-adenosylmethionine binding site [chemical binding]; other site 233413001353 Protein of unknown function (DUF732); Region: DUF732; pfam05305 233413001354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413001355 S-adenosylmethionine binding site [chemical binding]; other site 233413001356 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 233413001357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001358 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 233413001359 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 233413001360 substrate binding pocket [chemical binding]; other site 233413001361 chain length determination region; other site 233413001362 substrate-Mg2+ binding site; other site 233413001363 catalytic residues [active] 233413001364 aspartate-rich region 1; other site 233413001365 active site lid residues [active] 233413001366 aspartate-rich region 2; other site 233413001367 Peptidase family M48; Region: Peptidase_M48; cl12018 233413001368 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 233413001369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001370 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 233413001371 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 233413001372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001373 Protein of unknown function (DUF520); Region: DUF520; cl00723 233413001374 O-methyltransferase; Region: Methyltransf_2; pfam00891 233413001375 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 233413001376 Cytochrome P450; Region: p450; pfam00067 233413001377 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 233413001378 ATP cone domain; Region: ATP-cone; pfam03477 233413001379 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 233413001380 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 233413001381 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 233413001382 active site 233413001383 dimer interface [polypeptide binding]; other site 233413001384 effector binding site; other site 233413001385 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 233413001386 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 233413001387 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413001388 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 233413001389 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 233413001390 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 233413001391 active site 233413001392 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 233413001393 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 233413001394 putative active site [active] 233413001395 putative metal binding site [ion binding]; other site 233413001396 hypothetical protein; Provisional; Region: PRK07588 233413001397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 233413001399 dimerization interface [polypeptide binding]; other site 233413001400 putative DNA binding site [nucleotide binding]; other site 233413001401 putative Zn2+ binding site [ion binding]; other site 233413001402 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 233413001403 putative hydrophobic ligand binding site [chemical binding]; other site 233413001404 DinB superfamily; Region: DinB_2; cl00986 233413001405 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 233413001406 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 233413001407 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 233413001408 PE family; Region: PE; pfam00934 233413001409 Ubiquitin-like proteins; Region: UBQ; cl00155 233413001410 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 233413001411 Protein of unknown function DUF82; Region: DUF82; pfam01927 233413001412 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 233413001413 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 233413001414 putative active site [active] 233413001415 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 233413001416 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 233413001417 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460 233413001418 Predicted integral membrane protein [Function unknown]; Region: COG0392 233413001419 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 233413001420 Transcriptional regulators [Transcription]; Region: FadR; COG2186 233413001421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 233413001422 DNA-binding site [nucleotide binding]; DNA binding site 233413001423 FCD domain; Region: FCD; cl11656 233413001424 Permease; Region: Permease; cl00510 233413001425 Permease; Region: Permease; cl00510 233413001426 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413001427 mce related protein; Region: MCE; cl15431 233413001428 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 233413001429 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413001430 mce related protein; Region: MCE; cl15431 233413001431 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 233413001432 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413001433 mce related protein; Region: MCE; cl15431 233413001434 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413001435 mce related protein; Region: MCE; cl15431 233413001436 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 233413001437 Mb0608, mce2Db, len: 47 aa. Equivalent to 3' end of Rv0592, len: 508 aa, from Mycobacterium tuberculosis strain H37Rv, (95.7% identity in 47 aa overlap). mce2D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 secreted protein from Streptomyces coelicolor (337 aa); etc. Has highly Pro-rich C-terminus and may contain N-terminal signal or anchor sequence. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits mce2D into 2 parts, mce2Da and mce2Db.;MCE-FAMILY PROTEIN MCE2DB [SECOND PART] 233413001438 mce related protein; Region: MCE; cl15431 233413001439 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413001440 mce related protein; Region: MCE; cl15431 233413001441 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 233413001442 oligomeric interface; other site 233413001443 putative active site [active] 233413001444 homodimer interface [polypeptide binding]; other site 233413001445 Phd_YefM; Region: PhdYeFM; cl09153 233413001446 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 233413001447 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 233413001448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 233413001449 ATP binding site [chemical binding]; other site 233413001450 Mg2+ binding site [ion binding]; other site 233413001451 G-X-G motif; other site 233413001452 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 233413001453 dimerization interface [polypeptide binding]; other site 233413001454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 233413001455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 233413001456 active site 233413001457 phosphorylation site [posttranslational modification] 233413001458 intermolecular recognition site; other site 233413001459 dimerization interface [polypeptide binding]; other site 233413001460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 233413001461 DNA binding site [nucleotide binding] 233413001462 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 233413001463 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 233413001464 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 233413001465 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 233413001466 catalytic residues [active] 233413001467 catalytic nucleophile [active] 233413001468 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 233413001469 Probable transposase; Region: OrfB_IS605; pfam01385 233413001470 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 233413001471 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 233413001472 putative active site [active] 233413001473 SEC-C motif; Region: SEC-C; pfam02810 233413001474 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 233413001475 putative active site [active] 233413001476 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 233413001477 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 233413001478 dimer interface [polypeptide binding]; other site 233413001479 active site 233413001480 galactokinase; Provisional; Region: PRK00555 233413001481 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 233413001482 Protein of unknown function (DUF732); Region: DUF732; pfam05305 233413001483 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 233413001484 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 233413001485 putative active site [active] 233413001486 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 233413001487 Phd_YefM; Region: PhdYeFM; cl09153 233413001488 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 233413001489 oligomeric interface; other site 233413001490 putative active site [active] 233413001491 homodimer interface [polypeptide binding]; other site 233413001492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 233413001493 FIST N domain; Region: FIST; cl10701 233413001494 FIST C domain; Region: FIST_C; pfam10442 233413001495 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 233413001496 Mb0646c, recBb, len: 234 aa. Equivalent to 3' end of Rv0630c, len: 1094 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 234 aa overlap). Probable recB, exonuclease V, beta chain (exodeoxyribonuclease V, beta chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_2|recB|AAD46808.1 Escherichia coli RecB protein homolog from Mycobacterium smegmatis (1083 aa); P08394|EX5B_ECOLI|RORA|B2820 exodeoxyribonuclease v 135 kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V BETA CHAIN) from Escherichia coli strain K12 (1180 aa), FASTA scores: opt: 289, E(): 4.3e-11, (29.5 identity in 1059 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE HELICase, UVRD SUBFAMILY. CONSIST OF THREE SUBUNITS; RECB, RECC|Rv0631c AND RECD|Rv0629c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits recB into 2 parts, recBa and recBb.;PROBABLE EXONUCLEASE V (BETA CHAIN) RECBB [SECOND PART] (EXODEOXYRIBONUCLEASE V BETA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE) 233413001497 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413001498 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 233413001499 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 233413001500 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl15476 233413001501 enoyl-CoA hydratase; Provisional; Region: PRK06213 233413001502 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413001503 substrate binding site [chemical binding]; other site 233413001504 oxyanion hole (OAH) forming residues; other site 233413001505 trimer interface [polypeptide binding]; other site 233413001506 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413001507 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 233413001508 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 233413001509 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 233413001510 active site 233413001511 catalytic site [active] 233413001512 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 233413001513 active site 233413001514 catalytic site [active] 233413001515 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 233413001516 active site 233413001517 catalytic site [active] 233413001518 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 233413001519 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 233413001520 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 233413001521 putative homodimer interface [polypeptide binding]; other site 233413001522 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 233413001523 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 233413001524 23S rRNA interface [nucleotide binding]; other site 233413001525 L7/L12 interface [polypeptide binding]; other site 233413001526 putative thiostrepton binding site; other site 233413001527 L25 interface [polypeptide binding]; other site 233413001528 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 233413001529 mRNA/rRNA interface [nucleotide binding]; other site 233413001530 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 233413001531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413001532 S-adenosylmethionine binding site [chemical binding]; other site 233413001533 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 233413001534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413001535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413001536 S-adenosylmethionine binding site [chemical binding]; other site 233413001537 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 233413001538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413001539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413001540 S-adenosylmethionine binding site [chemical binding]; other site 233413001541 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 233413001542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413001543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413001544 S-adenosylmethionine binding site [chemical binding]; other site 233413001545 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413001546 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413001547 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 233413001548 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 233413001549 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 233413001550 active site 233413001551 ATP binding site [chemical binding]; other site 233413001552 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 233413001553 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 233413001554 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 233413001555 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 233413001556 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 233413001557 N-acetylmannosamine kinase; Provisional; Region: PRK05082 233413001558 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 233413001559 23S rRNA interface [nucleotide binding]; other site 233413001560 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 233413001561 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 233413001562 core dimer interface [polypeptide binding]; other site 233413001563 peripheral dimer interface [polypeptide binding]; other site 233413001564 L10 interface [polypeptide binding]; other site 233413001565 L11 interface [polypeptide binding]; other site 233413001566 putative EF-Tu interaction site [polypeptide binding]; other site 233413001567 putative EF-G interaction site [polypeptide binding]; other site 233413001568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413001569 Helix-turn-helix domains; Region: HTH; cl00088 233413001570 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 233413001571 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 233413001572 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 233413001573 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 233413001574 Walker A/P-loop; other site 233413001575 ATP binding site [chemical binding]; other site 233413001576 Q-loop/lid; other site 233413001577 ABC transporter signature motif; other site 233413001578 Walker B; other site 233413001579 D-loop; other site 233413001580 H-loop/switch region; other site 233413001581 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413001582 putative active site [active] 233413001583 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 233413001584 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 233413001585 PemK-like protein; Region: PemK; cl00995 233413001586 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413001587 Sulfatase; Region: Sulfatase; cl10460 233413001588 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413001589 putative active site [active] 233413001590 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 233413001591 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 233413001592 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 233413001593 RPB10 interaction site [polypeptide binding]; other site 233413001594 RPB1 interaction site [polypeptide binding]; other site 233413001595 RPB11 interaction site [polypeptide binding]; other site 233413001596 RPB3 interaction site [polypeptide binding]; other site 233413001597 RPB12 interaction site [polypeptide binding]; other site 233413001598 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 233413001599 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 233413001600 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 233413001601 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 233413001602 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 233413001603 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 233413001604 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 233413001605 G-loop; other site 233413001606 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 233413001607 DNA binding site [nucleotide binding] 233413001608 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 233413001609 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 233413001610 endonuclease IV; Provisional; Region: PRK01060 233413001611 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 233413001612 AP (apurinic/apyrimidinic) site pocket; other site 233413001613 DNA interaction; other site 233413001614 Metal-binding active site; metal-binding site 233413001615 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 233413001616 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413001617 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 233413001618 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413001619 active site 233413001620 enoyl-CoA hydratase; Provisional; Region: PRK08272 233413001621 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413001622 substrate binding site [chemical binding]; other site 233413001623 oxyanion hole (OAH) forming residues; other site 233413001624 trimer interface [polypeptide binding]; other site 233413001625 PaaX-like protein; Region: PaaX; pfam07848 233413001626 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 233413001627 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413001628 substrate binding site [chemical binding]; other site 233413001629 oxyanion hole (OAH) forming residues; other site 233413001630 trimer interface [polypeptide binding]; other site 233413001631 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 233413001632 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 233413001633 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 233413001634 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 233413001635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413001636 Helix-turn-helix domains; Region: HTH; cl00088 233413001637 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 233413001638 S17 interaction site [polypeptide binding]; other site 233413001639 S8 interaction site; other site 233413001640 16S rRNA interaction site [nucleotide binding]; other site 233413001641 streptomycin interaction site [chemical binding]; other site 233413001642 23S rRNA interaction site [nucleotide binding]; other site 233413001643 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 233413001644 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 233413001645 elongation factor G; Reviewed; Region: PRK00007 233413001646 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 233413001647 G1 box; other site 233413001648 putative GEF interaction site [polypeptide binding]; other site 233413001649 GTP/Mg2+ binding site [chemical binding]; other site 233413001650 Switch I region; other site 233413001651 G2 box; other site 233413001652 G3 box; other site 233413001653 Switch II region; other site 233413001654 G4 box; other site 233413001655 G5 box; other site 233413001656 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 233413001657 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 233413001658 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 233413001659 elongation factor Tu; Reviewed; Region: PRK00049 233413001660 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 233413001661 G1 box; other site 233413001662 GEF interaction site [polypeptide binding]; other site 233413001663 GTP/Mg2+ binding site [chemical binding]; other site 233413001664 Switch I region; other site 233413001665 G2 box; other site 233413001666 G3 box; other site 233413001667 Switch II region; other site 233413001668 G4 box; other site 233413001669 G5 box; other site 233413001670 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 233413001671 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 233413001672 Antibiotic Binding Site [chemical binding]; other site 233413001673 Short C-terminal domain; Region: SHOCT; cl01373 233413001674 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 233413001675 classical (c) SDRs; Region: SDR_c; cd05233 233413001676 NAD(P) binding site [chemical binding]; other site 233413001677 active site 233413001678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 233413001679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001680 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 233413001681 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 233413001682 Helix-turn-helix domains; Region: HTH; cl00088 233413001683 mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967 233413001684 mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962 233413001685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413001686 FeS/SAM binding site; other site 233413001687 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 233413001688 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 233413001689 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 233413001690 phosphate binding site [ion binding]; other site 233413001691 Creatinine amidohydrolase; Region: Creatininase; cl00618 233413001692 mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965 233413001693 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 233413001694 Probable Catalytic site; other site 233413001695 metal-binding site 233413001696 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 233413001697 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 233413001698 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 233413001699 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 233413001700 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 233413001701 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 233413001702 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 233413001703 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 233413001704 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 233413001705 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 233413001706 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 233413001707 putative translocon binding site; other site 233413001708 protein-rRNA interface [nucleotide binding]; other site 233413001709 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 233413001710 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 233413001711 G-X-X-G motif; other site 233413001712 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 233413001713 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 233413001714 23S rRNA interface [nucleotide binding]; other site 233413001715 5S rRNA interface [nucleotide binding]; other site 233413001716 putative antibiotic binding site [chemical binding]; other site 233413001717 L25 interface [polypeptide binding]; other site 233413001718 L27 interface [polypeptide binding]; other site 233413001719 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 233413001720 putative translocon interaction site; other site 233413001721 23S rRNA interface [nucleotide binding]; other site 233413001722 signal recognition particle (SRP54) interaction site; other site 233413001723 L23 interface [polypeptide binding]; other site 233413001724 trigger factor interaction site; other site 233413001725 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 233413001726 Sulfatase; Region: Sulfatase; cl10460 233413001727 Sulfatase; Region: Sulfatase; cl10460 233413001728 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 233413001729 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 233413001730 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 233413001731 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 233413001732 KOW motif; Region: KOW; cl00354 233413001733 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 233413001734 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 233413001735 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 233413001736 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 233413001737 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 233413001738 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 233413001739 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 233413001740 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 233413001741 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 233413001742 5S rRNA interface [nucleotide binding]; other site 233413001743 23S rRNA interface [nucleotide binding]; other site 233413001744 L5 interface [polypeptide binding]; other site 233413001745 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 233413001746 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 233413001747 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 233413001748 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 233413001749 23S rRNA binding site [nucleotide binding]; other site 233413001750 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 233413001751 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 233413001752 tandem repeat interface [polypeptide binding]; other site 233413001753 oligomer interface [polypeptide binding]; other site 233413001754 active site residues [active] 233413001755 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 233413001756 tandem repeat interface [polypeptide binding]; other site 233413001757 oligomer interface [polypeptide binding]; other site 233413001758 active site residues [active] 233413001759 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413001760 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413001761 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 233413001762 intersubunit interface [polypeptide binding]; other site 233413001763 active site 233413001764 Zn2+ binding site [ion binding]; other site 233413001765 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 233413001766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001767 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 233413001768 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 233413001769 N- and C-terminal domain interface [polypeptide binding]; other site 233413001770 active site 233413001771 MgATP binding site [chemical binding]; other site 233413001772 catalytic site [active] 233413001773 metal binding site [ion binding]; metal-binding site 233413001774 carbohydrate binding site [chemical binding]; other site 233413001775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 233413001776 Coenzyme A binding pocket [chemical binding]; other site 233413001777 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413001778 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 233413001779 SecY translocase; Region: SecY; pfam00344 233413001780 adenylate kinase; Reviewed; Region: adk; PRK00279 233413001781 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 233413001782 AMP-binding site [chemical binding]; other site 233413001783 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 233413001784 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 233413001785 active site 233413001786 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 233413001787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 233413001788 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 233413001789 DNA binding residues [nucleotide binding] 233413001790 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 233413001791 Helix-turn-helix domains; Region: HTH; cl00088 233413001792 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 233413001793 DinB superfamily; Region: DinB_2; cl00986 233413001794 Biofilm regulator BssS; Region: BssS; pfam10774 233413001795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 233413001796 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 233413001797 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 233413001798 PE family; Region: PE; pfam00934 233413001799 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 233413001800 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413001801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001802 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 233413001803 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413001804 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 233413001805 substrate binding pocket [chemical binding]; other site 233413001806 FAD binding site [chemical binding]; other site 233413001807 catalytic base [active] 233413001808 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 233413001809 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 233413001810 tetrameric interface [polypeptide binding]; other site 233413001811 NAD binding site [chemical binding]; other site 233413001812 catalytic residues [active] 233413001813 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 233413001814 PPE family; Region: PPE; pfam00823 233413001815 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413001816 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413001817 Helix-turn-helix domains; Region: HTH; cl00088 233413001818 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 233413001819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 233413001820 active site 233413001821 phosphorylation site [posttranslational modification] 233413001822 intermolecular recognition site; other site 233413001823 dimerization interface [polypeptide binding]; other site 233413001824 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 233413001825 DNA binding site [nucleotide binding] 233413001826 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 233413001827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 233413001828 dimer interface [polypeptide binding]; other site 233413001829 phosphorylation site [posttranslational modification] 233413001830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 233413001831 ATP binding site [chemical binding]; other site 233413001832 Mg2+ binding site [ion binding]; other site 233413001833 G-X-G motif; other site 233413001834 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 233413001835 nucleotide binding site/active site [active] 233413001836 HIT family signature motif; other site 233413001837 catalytic residue [active] 233413001838 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 233413001839 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 233413001840 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 233413001841 NAD binding site [chemical binding]; other site 233413001842 catalytic Zn binding site [ion binding]; other site 233413001843 substrate binding site [chemical binding]; other site 233413001844 structural Zn binding site [ion binding]; other site 233413001845 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 233413001846 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 233413001847 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 233413001848 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 233413001849 Cytochrome P450; Region: p450; pfam00067 233413001850 classical (c) SDRs; Region: SDR_c; cd05233 233413001851 NAD(P) binding site [chemical binding]; other site 233413001852 active site 233413001853 Cytochrome P450; Region: p450; cl12078 233413001854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413001855 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 233413001856 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 233413001857 NAD binding site [chemical binding]; other site 233413001858 catalytic residues [active] 233413001859 short chain dehydrogenase; Provisional; Region: PRK07774 233413001860 classical (c) SDRs; Region: SDR_c; cd05233 233413001861 NAD(P) binding site [chemical binding]; other site 233413001862 active site 233413001863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001864 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 233413001865 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 233413001866 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 233413001867 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 233413001868 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 233413001869 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 233413001870 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 233413001871 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 233413001872 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 233413001873 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413001874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 233413001875 Protein of unknown function (DUF429); Region: DUF429; cl12046 233413001876 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 233413001877 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 233413001878 tetramer interface [polypeptide binding]; other site 233413001879 active site 233413001880 Cytochrome P450; Region: p450; cl12078 233413001881 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 233413001882 ATP binding site [chemical binding]; other site 233413001883 active site 233413001884 substrate binding site [chemical binding]; other site 233413001885 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 233413001886 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413001887 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 233413001888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413001889 putative substrate translocation pore; other site 233413001890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413001891 Predicted deacetylase [General function prediction only]; Region: COG3233 233413001892 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 233413001893 putative active site [active] 233413001894 putative Zn binding site [ion binding]; other site 233413001895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413001898 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 233413001899 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 233413001900 putative active site [active] 233413001901 catalytic triad [active] 233413001902 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 233413001903 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 233413001904 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 233413001905 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 233413001906 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 233413001907 DNA-binding site [nucleotide binding]; DNA binding site 233413001908 UTRA domain; Region: UTRA; cl01230 233413001909 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 233413001910 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 233413001911 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 233413001912 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 233413001913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413001915 Transposase; Region: DEDD_Tnp_IS110; pfam01548 233413001916 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 233413001917 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 233413001918 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 233413001919 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 233413001920 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 233413001921 active site 233413001922 metal binding site [ion binding]; metal-binding site 233413001923 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 233413001924 active site 233413001925 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 233413001926 metal binding site [ion binding]; metal-binding site 233413001927 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 233413001928 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 233413001929 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 233413001930 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 233413001931 dimerization interface [polypeptide binding]; other site 233413001932 ATP binding site [chemical binding]; other site 233413001933 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 233413001934 dimerization interface [polypeptide binding]; other site 233413001935 ATP binding site [chemical binding]; other site 233413001936 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 233413001937 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 233413001938 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 233413001939 active site 233413001940 metal binding site [ion binding]; metal-binding site 233413001941 hexamer interface [polypeptide binding]; other site 233413001942 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 233413001943 amidophosphoribosyltransferase; Provisional; Region: PRK07847 233413001944 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 233413001945 active site 233413001946 tetramer interface [polypeptide binding]; other site 233413001947 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 233413001948 active site 233413001949 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 233413001950 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 233413001951 dimerization interface [polypeptide binding]; other site 233413001952 putative ATP binding site [chemical binding]; other site 233413001953 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 233413001954 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 233413001955 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 233413001956 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 233413001957 Aminotransferase class IV; Region: Aminotran_4; pfam01063 233413001958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413001959 catalytic residue [active] 233413001960 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 233413001961 heme-binding site [chemical binding]; other site 233413001962 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 233413001963 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 233413001964 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 233413001965 active site residue [active] 233413001966 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 233413001967 active site residue [active] 233413001968 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 233413001969 catalytic residues [active] 233413001970 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 233413001971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 233413001972 DNA binding site [nucleotide binding] 233413001973 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 233413001974 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 233413001975 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 233413001976 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 233413001977 Walker A/P-loop; other site 233413001978 ATP binding site [chemical binding]; other site 233413001979 Q-loop/lid; other site 233413001980 ABC transporter signature motif; other site 233413001981 Walker B; other site 233413001982 D-loop; other site 233413001983 H-loop/switch region; other site 233413001984 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 233413001985 PhoU domain; Region: PhoU; pfam01895 233413001986 PhoU domain; Region: PhoU; pfam01895 233413001987 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 233413001988 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 233413001989 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 233413001990 FMN binding site [chemical binding]; other site 233413001991 active site 233413001992 catalytic residues [active] 233413001993 substrate binding site [chemical binding]; other site 233413001994 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 233413001995 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 233413001996 homodimer interface [polypeptide binding]; other site 233413001997 putative substrate binding pocket [chemical binding]; other site 233413001998 diiron center [ion binding]; other site 233413001999 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 233413002000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 233413002001 dimerization interface [polypeptide binding]; other site 233413002002 putative DNA binding site [nucleotide binding]; other site 233413002003 putative Zn2+ binding site [ion binding]; other site 233413002004 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 233413002005 dimer interface [polypeptide binding]; other site 233413002006 catalytic motif [active] 233413002007 nucleoside/Zn binding site; other site 233413002008 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 233413002009 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413002010 PE family; Region: PE; pfam00934 233413002011 PE family; Region: PE; pfam00934 233413002012 PknH-like extracellular domain; Region: PknH_C; pfam14032 233413002013 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 233413002014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 233413002015 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 233413002016 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 233413002017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413002018 S-adenosylmethionine binding site [chemical binding]; other site 233413002019 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 233413002020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413002021 putative substrate translocation pore; other site 233413002022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 233413002023 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 233413002024 tetramer interface [polypeptide binding]; other site 233413002025 TPP-binding site [chemical binding]; other site 233413002026 heterodimer interface [polypeptide binding]; other site 233413002027 phosphorylation loop region [posttranslational modification] 233413002028 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 233413002029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 233413002030 active site 233413002031 phosphorylation site [posttranslational modification] 233413002032 intermolecular recognition site; other site 233413002033 dimerization interface [polypeptide binding]; other site 233413002034 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 233413002035 DNA binding residues [nucleotide binding] 233413002036 dimerization interface [polypeptide binding]; other site 233413002037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 233413002038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 233413002039 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 233413002040 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 233413002041 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 233413002042 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 233413002043 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 233413002044 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 233413002045 dimer interface [polypeptide binding]; other site 233413002046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413002047 catalytic residue [active] 233413002048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413002049 multidrug resistance protein MdtH; Provisional; Region: PRK11646 233413002050 putative substrate translocation pore; other site 233413002051 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 233413002052 hypothetical protein; Provisional; Region: PRK06194 233413002053 classical (c) SDRs; Region: SDR_c; cd05233 233413002054 NAD(P) binding site [chemical binding]; other site 233413002055 active site 233413002056 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 233413002057 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 233413002058 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 233413002059 dimer interface [polypeptide binding]; other site 233413002060 PYR/PP interface [polypeptide binding]; other site 233413002061 TPP binding site [chemical binding]; other site 233413002062 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 233413002063 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 233413002064 TPP-binding site [chemical binding]; other site 233413002065 dimer interface [polypeptide binding]; other site 233413002066 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 233413002067 putative hydrophobic ligand binding site [chemical binding]; other site 233413002068 CoA-transferase family III; Region: CoA_transf_3; pfam02515 233413002069 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 233413002070 putative hydrophobic ligand binding site [chemical binding]; other site 233413002071 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 233413002072 putative hydrophobic ligand binding site [chemical binding]; other site 233413002073 aminotransferase; Validated; Region: PRK07777 233413002074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 233413002075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413002076 homodimer interface [polypeptide binding]; other site 233413002077 catalytic residue [active] 233413002078 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 233413002079 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 233413002080 dimer interface [polypeptide binding]; other site 233413002081 active site 233413002082 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 233413002083 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413002084 substrate binding site [chemical binding]; other site 233413002085 oxyanion hole (OAH) forming residues; other site 233413002086 trimer interface [polypeptide binding]; other site 233413002087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413002088 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 233413002089 DNA repair helicase rad25; Region: rad25; TIGR00603 233413002090 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 233413002091 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413002092 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 233413002093 nucleotide binding region [chemical binding]; other site 233413002094 ATP-binding site [chemical binding]; other site 233413002095 Predicted transcriptional regulator [Transcription]; Region: COG2378 233413002096 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 233413002097 trimer interface [polypeptide binding]; other site 233413002098 dimer interface [polypeptide binding]; other site 233413002099 putative active site [active] 233413002100 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 233413002101 MPT binding site; other site 233413002102 trimer interface [polypeptide binding]; other site 233413002103 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 233413002104 MoaE homodimer interface [polypeptide binding]; other site 233413002105 MoaD interaction [polypeptide binding]; other site 233413002106 active site residues [active] 233413002107 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 233413002108 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 233413002109 MoaE interaction surface [polypeptide binding]; other site 233413002110 MoeB interaction surface [polypeptide binding]; other site 233413002111 thiocarboxylated glycine; other site 233413002112 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 233413002113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413002114 FeS/SAM binding site; other site 233413002115 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 233413002116 hypothetical protein; Provisional; Region: PRK11770 233413002117 Domain of unknown function (DUF307); Region: DUF307; pfam03733 233413002118 Domain of unknown function (DUF307); Region: DUF307; pfam03733 233413002119 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 233413002120 DNA-binding site [nucleotide binding]; DNA binding site 233413002121 RNA-binding motif; other site 233413002122 PE family; Region: PE; pfam00934 233413002123 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413002124 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413002125 active site 233413002126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 233413002127 FIST N domain; Region: FIST; cl10701 233413002128 FIST C domain; Region: FIST_C; pfam10442 233413002129 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 233413002130 H+ Antiporter protein; Region: 2A0121; TIGR00900 233413002131 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 233413002132 PPE family; Region: PPE; pfam00823 233413002133 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413002134 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413002135 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 233413002136 Helix-turn-helix domains; Region: HTH; cl00088 233413002137 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 233413002138 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 233413002139 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 233413002140 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 233413002141 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 233413002142 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 233413002143 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413002144 catalytic residue [active] 233413002145 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 233413002146 Ferredoxin [Energy production and conversion]; Region: COG1146 233413002147 4Fe-4S binding domain; Region: Fer4; cl02805 233413002148 ferredoxin-NADP+ reductase; Region: PLN02852 233413002149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413002150 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 233413002151 putative dimer interface [polypeptide binding]; other site 233413002152 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 233413002153 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 233413002154 putative catalytic site [active] 233413002155 putative phosphate binding site [ion binding]; other site 233413002156 putative metal binding site [ion binding]; other site 233413002157 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 233413002158 dimer interface [polypeptide binding]; other site 233413002159 Citrate synthase; Region: Citrate_synt; pfam00285 233413002160 active site 233413002161 citrylCoA binding site [chemical binding]; other site 233413002162 oxalacetate/citrate binding site [chemical binding]; other site 233413002163 coenzyme A binding site [chemical binding]; other site 233413002164 catalytic triad [active] 233413002165 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413002166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 233413002167 DNA binding residues [nucleotide binding] 233413002168 dimerization interface [polypeptide binding]; other site 233413002169 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 233413002170 cyclase homology domain; Region: CHD; cd07302 233413002171 nucleotidyl binding site; other site 233413002172 metal binding site [ion binding]; metal-binding site 233413002173 dimer interface [polypeptide binding]; other site 233413002174 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 233413002175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413002176 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413002177 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413002178 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413002179 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413002180 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 233413002181 dimer interface [polypeptide binding]; other site 233413002182 Citrate synthase; Region: Citrate_synt; pfam00285 233413002183 active site 233413002184 citrylCoA binding site [chemical binding]; other site 233413002185 NADH binding [chemical binding]; other site 233413002186 cationic pore residues; other site 233413002187 oxalacetate/citrate binding site [chemical binding]; other site 233413002188 coenzyme A binding site [chemical binding]; other site 233413002189 catalytic triad [active] 233413002190 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 233413002191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413002192 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 233413002193 BON domain; Region: BON; cl02771 233413002194 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 233413002195 ligand binding site [chemical binding]; other site 233413002196 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 233413002197 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 233413002198 dimerization interface [polypeptide binding]; other site 233413002199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 233413002200 dimer interface [polypeptide binding]; other site 233413002201 phosphorylation site [posttranslational modification] 233413002202 two-component sensor protein; Provisional; Region: cpxA; PRK09470 233413002203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 233413002204 Mg2+ binding site [ion binding]; other site 233413002205 G-X-G motif; other site 233413002206 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 233413002207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 233413002208 active site 233413002209 phosphorylation site [posttranslational modification] 233413002210 intermolecular recognition site; other site 233413002211 dimerization interface [polypeptide binding]; other site 233413002212 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 233413002213 DNA binding site [nucleotide binding] 233413002214 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 233413002215 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 233413002216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413002217 enoyl-CoA hydratase; Provisional; Region: PRK06688 233413002218 substrate binding site [chemical binding]; other site 233413002219 oxyanion hole (OAH) forming residues; other site 233413002220 trimer interface [polypeptide binding]; other site 233413002221 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413002222 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 233413002223 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413002224 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 233413002225 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 233413002226 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 233413002227 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413002228 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 233413002229 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 233413002230 hydrophobic ligand binding site; other site 233413002231 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 233413002232 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 233413002233 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 233413002234 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 233413002235 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 233413002236 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 233413002237 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 233413002238 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 233413002239 active site 233413002240 PPE family; Region: PPE; pfam00823 233413002241 PE family; Region: PE; pfam00934 233413002242 BCCT family transporter; Region: BCCT; cl00569 233413002243 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 233413002244 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 233413002245 Transposase, Mutator family; Region: Transposase_mut; pfam00872 233413002246 MULE transposase domain; Region: MULE; pfam10551 233413002247 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 233413002248 catalytic residues [active] 233413002249 catalytic nucleophile [active] 233413002250 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 233413002251 Probable transposase; Region: OrfB_IS605; pfam01385 233413002252 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 233413002253 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 233413002254 putative active site pocket [active] 233413002255 dimerization interface [polypeptide binding]; other site 233413002256 putative catalytic residue [active] 233413002257 Protein of unknown function (DUF867); Region: DUF867; cl01713 233413002258 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 233413002259 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 233413002260 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 233413002261 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 233413002262 classical (c) SDRs; Region: SDR_c; cd05233 233413002263 NAD(P) binding site [chemical binding]; other site 233413002264 active site 233413002265 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 233413002266 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 233413002267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413002268 dimer interface [polypeptide binding]; other site 233413002269 conserved gate region; other site 233413002270 putative PBP binding loops; other site 233413002271 ABC-ATPase subunit interface; other site 233413002272 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 233413002273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413002274 dimer interface [polypeptide binding]; other site 233413002275 conserved gate region; other site 233413002276 putative PBP binding loops; other site 233413002277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 233413002278 ABC-ATPase subunit interface; other site 233413002279 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 233413002280 NHL repeat; Region: NHL; pfam01436 233413002281 NHL repeat; Region: NHL; pfam01436 233413002282 NHL repeat; Region: NHL; pfam01436 233413002283 NHL repeat; Region: NHL; pfam01436 233413002284 NHL repeat; Region: NHL; pfam01436 233413002285 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 233413002286 Catalytic domain of Protein Kinases; Region: PKc; cd00180 233413002287 active site 233413002288 ATP binding site [chemical binding]; other site 233413002289 substrate binding site [chemical binding]; other site 233413002290 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 233413002291 substrate binding site [chemical binding]; other site 233413002292 activation loop (A-loop); other site 233413002293 activation loop (A-loop); other site 233413002294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 233413002295 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413002296 Walker A/P-loop; other site 233413002297 ATP binding site [chemical binding]; other site 233413002298 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 233413002299 Q-loop/lid; other site 233413002300 ABC transporter signature motif; other site 233413002301 Walker B; other site 233413002302 D-loop; other site 233413002303 H-loop/switch region; other site 233413002304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 233413002305 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 233413002306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 233413002307 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 233413002308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413002309 dimer interface [polypeptide binding]; other site 233413002310 conserved gate region; other site 233413002311 putative PBP binding loops; other site 233413002312 ABC-ATPase subunit interface; other site 233413002313 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 233413002314 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 233413002315 putative DNA binding site [nucleotide binding]; other site 233413002316 putative homodimer interface [polypeptide binding]; other site 233413002317 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 233413002318 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 233413002319 nucleotide binding site [chemical binding]; other site 233413002320 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 233413002321 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 233413002322 active site 233413002323 DNA binding site [nucleotide binding] 233413002324 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 233413002325 DNA binding site [nucleotide binding] 233413002326 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 233413002327 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 233413002328 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 233413002329 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413002330 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 233413002331 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 233413002332 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 233413002333 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 233413002334 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 233413002335 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 233413002336 short chain dehydrogenase; Provisional; Region: PRK08251 233413002337 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 233413002338 putative NAD(P) binding site [chemical binding]; other site 233413002339 active site 233413002340 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 233413002341 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 233413002342 active site 233413002343 dimer interface [polypeptide binding]; other site 233413002344 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 233413002345 dimer interface [polypeptide binding]; other site 233413002346 active site 233413002347 Chorismate mutase type II; Region: CM_2; cl00693 233413002348 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 233413002349 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413002350 Peptidase family M23; Region: Peptidase_M23; pfam01551 233413002351 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 233413002352 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 233413002353 CoA-ligase; Region: Ligase_CoA; pfam00549 233413002354 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 233413002355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413002356 CoA-ligase; Region: Ligase_CoA; pfam00549 233413002357 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 233413002358 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 233413002359 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Region: PurN; TIGR00639 233413002360 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 233413002361 active site 233413002362 substrate binding site [chemical binding]; other site 233413002363 cosubstrate binding site; other site 233413002364 catalytic site [active] 233413002365 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 233413002366 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 233413002367 purine monophosphate binding site [chemical binding]; other site 233413002368 dimer interface [polypeptide binding]; other site 233413002369 putative catalytic residues [active] 233413002370 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 233413002371 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 233413002372 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 233413002373 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413002374 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 233413002375 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 233413002376 homotetrameric interface [polypeptide binding]; other site 233413002377 putative active site [active] 233413002378 metal binding site [ion binding]; metal-binding site 233413002379 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 233413002380 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 233413002381 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 233413002382 putative homotetramer interface [polypeptide binding]; other site 233413002383 putative homodimer interface [polypeptide binding]; other site 233413002384 allosteric switch controlling residues; other site 233413002385 putative metal binding site [ion binding]; other site 233413002386 putative homodimer-homodimer interface [polypeptide binding]; other site 233413002387 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 233413002388 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 233413002389 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 233413002390 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413002391 enoyl-CoA hydratase; Provisional; Region: PRK07827 233413002392 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413002393 substrate binding site [chemical binding]; other site 233413002394 oxyanion hole (OAH) forming residues; other site 233413002395 trimer interface [polypeptide binding]; other site 233413002396 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413002397 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 233413002398 active site 233413002399 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 233413002400 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 233413002401 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 233413002402 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 233413002403 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 233413002404 carboxyltransferase (CT) interaction site; other site 233413002405 biotinylation site [posttranslational modification]; other site 233413002406 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 233413002407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 233413002408 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413002409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413002410 active site 233413002411 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 233413002412 PE family; Region: PE; pfam00934 233413002413 PE family; Region: PE; pfam00934 233413002414 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 233413002415 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 233413002416 PE family; Region: PE; pfam00934 233413002417 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 233413002418 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 233413002419 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 233413002420 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 233413002421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 233413002422 active site 233413002423 phosphorylation site [posttranslational modification] 233413002424 intermolecular recognition site; other site 233413002425 dimerization interface [polypeptide binding]; other site 233413002426 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 233413002427 DNA binding site [nucleotide binding] 233413002428 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 233413002429 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 233413002430 dimerization interface [polypeptide binding]; other site 233413002431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 233413002432 dimer interface [polypeptide binding]; other site 233413002433 phosphorylation site [posttranslational modification] 233413002434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 233413002435 ATP binding site [chemical binding]; other site 233413002436 Mg2+ binding site [ion binding]; other site 233413002437 G-X-G motif; other site 233413002438 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 233413002439 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 233413002440 MPT binding site; other site 233413002441 trimer interface [polypeptide binding]; other site 233413002442 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 233413002443 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 233413002444 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 233413002445 Walker A/P-loop; other site 233413002446 ATP binding site [chemical binding]; other site 233413002447 Q-loop/lid; other site 233413002448 ABC transporter signature motif; other site 233413002449 Walker B; other site 233413002450 D-loop; other site 233413002451 H-loop/switch region; other site 233413002452 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 233413002453 FtsX-like permease family; Region: FtsX; pfam02687 233413002454 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 233413002455 FtsX-like permease family; Region: FtsX; pfam02687 233413002456 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 233413002457 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 233413002458 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 233413002459 substrate binding pocket [chemical binding]; other site 233413002460 chain length determination region; other site 233413002461 substrate-Mg2+ binding site; other site 233413002462 catalytic residues [active] 233413002463 aspartate-rich region 1; other site 233413002464 active site lid residues [active] 233413002465 aspartate-rich region 2; other site 233413002466 SAF domain; Region: SAF; cl00555 233413002467 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 233413002468 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 233413002469 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 233413002470 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 233413002471 active site 233413002472 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 233413002473 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 233413002474 dimer interface [polypeptide binding]; other site 233413002475 putative functional site; other site 233413002476 putative MPT binding site; other site 233413002477 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 233413002478 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 233413002479 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 233413002480 ligand binding site [chemical binding]; other site 233413002481 flexible hinge region; other site 233413002482 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 233413002483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 233413002484 Coenzyme A binding pocket [chemical binding]; other site 233413002485 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 233413002486 Amidinotransferase; Region: Amidinotransf; cl12043 233413002487 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 233413002488 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 233413002489 Predicted methyltransferases [General function prediction only]; Region: COG0313 233413002490 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 233413002491 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 233413002492 chorismate binding enzyme; Region: Chorismate_bind; cl10555 233413002493 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 233413002494 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 233413002495 active site 233413002496 HIGH motif; other site 233413002497 KMSKS motif; other site 233413002498 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 233413002499 tRNA binding surface [nucleotide binding]; other site 233413002500 anticodon binding site; other site 233413002501 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 233413002502 active site 233413002503 Domain of unknown function (DUF348); Region: DUF348; pfam03990 233413002504 Domain of unknown function (DUF348); Region: DUF348; pfam03990 233413002505 Domain of unknown function (DUF348); Region: DUF348; pfam03990 233413002506 G5 domain; Region: G5; pfam07501 233413002507 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 233413002508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413002509 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 233413002510 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 233413002511 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 233413002512 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413002513 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 233413002514 putative active site [active] 233413002515 catalytic residue [active] 233413002516 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 233413002517 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 233413002518 5S rRNA interface [nucleotide binding]; other site 233413002519 CTC domain interface [polypeptide binding]; other site 233413002520 L16 interface [polypeptide binding]; other site 233413002521 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 233413002522 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 233413002523 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 233413002524 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 233413002525 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 233413002526 Substrate binding site; other site 233413002527 Mg++ binding site; other site 233413002528 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 233413002529 active site 233413002530 substrate binding site [chemical binding]; other site 233413002531 CoA binding site [chemical binding]; other site 233413002532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413002533 Helix-turn-helix domains; Region: HTH; cl00088 233413002534 transcription-repair coupling factor; Provisional; Region: PRK10689 233413002535 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 233413002536 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 233413002537 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 233413002538 ATP binding site [chemical binding]; other site 233413002539 putative Mg++ binding site [ion binding]; other site 233413002540 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 233413002541 nucleotide binding region [chemical binding]; other site 233413002542 ATP-binding site [chemical binding]; other site 233413002543 TRCF domain; Region: TRCF; cl04088 233413002544 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 233413002545 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 233413002546 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 233413002547 N-acetyl-D-glucosamine binding site [chemical binding]; other site 233413002548 enolase; Provisional; Region: eno; PRK00077 233413002549 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 233413002550 dimer interface [polypeptide binding]; other site 233413002551 metal binding site [ion binding]; metal-binding site 233413002552 substrate binding pocket [chemical binding]; other site 233413002553 Septum formation initiator; Region: DivIC; cl11433 233413002554 Protein of unknown function (DUF501); Region: DUF501; cl00652 233413002555 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 233413002556 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 233413002557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 233413002558 active site 233413002559 phosphorylation site [posttranslational modification] 233413002560 intermolecular recognition site; other site 233413002561 dimerization interface [polypeptide binding]; other site 233413002562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 233413002563 DNA binding site [nucleotide binding] 233413002564 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 233413002565 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 233413002566 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 233413002567 Ligand Binding Site [chemical binding]; other site 233413002568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 233413002569 dimer interface [polypeptide binding]; other site 233413002570 phosphorylation site [posttranslational modification] 233413002571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 233413002572 ATP binding site [chemical binding]; other site 233413002573 Mg2+ binding site [ion binding]; other site 233413002574 G-X-G motif; other site 233413002575 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 233413002576 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 233413002577 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 233413002578 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413002579 K+-transporting ATPase, c chain; Region: KdpC; cl00944 233413002580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 233413002581 dimer interface [polypeptide binding]; other site 233413002582 phosphorylation site [posttranslational modification] 233413002583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 233413002584 ATP binding site [chemical binding]; other site 233413002585 Mg2+ binding site [ion binding]; other site 233413002586 G-X-G motif; other site 233413002587 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 233413002588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 233413002589 active site 233413002590 phosphorylation site [posttranslational modification] 233413002591 intermolecular recognition site; other site 233413002592 dimerization interface [polypeptide binding]; other site 233413002593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 233413002594 DNA binding site [nucleotide binding] 233413002595 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 233413002596 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 233413002597 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413002598 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413002599 PPE family; Region: PPE; pfam00823 233413002600 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413002601 PE family; Region: PE; pfam00934 233413002602 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413002603 Mb1070c, -, len: 183 aa. Equivalent to Rv1041c, len: 287 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 183 aa overlap). Probable IS like-2 transposase, overlaps MTCY10G2.07. Similar to Q00430|X53945 insertion element IS869 hypothetical protein from Agrobacterium tumefaciens (186 aa), FASTA scores: opt: 173, E(): 0.00016, (40.9% identity in 176 aa overlap). Similar to Rv1150, C-terminal part of transposase of Mycobacterium tuberculosis IS like-1. MTCY10G2.07 and MTCY10G2.08 are frameshifted with respect to Mycobacterium tuberculosis Q50761 transposase, the 10G2 cosmid sequence appears to be correct.; IS LIKE-2 TRANSPOSASE 233413002604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 233413002605 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 233413002606 Predicted transcriptional regulator [Transcription]; Region: COG5340 233413002607 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 233413002608 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 233413002609 Transposase, Mutator family; Region: Transposase_mut; pfam00872 233413002610 MULE transposase domain; Region: MULE; pfam10551 233413002611 Transcriptional regulators [Transcription]; Region: MarR; COG1846 233413002612 Helix-turn-helix domains; Region: HTH; cl00088 233413002613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413002614 NAD(P) binding site [chemical binding]; other site 233413002615 active site 233413002616 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 233413002617 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 233413002618 Domain of unknown function (DUF427); Region: DUF427; cl00998 233413002619 D-lactate dehydrogenase; Provisional; Region: PRK11183 233413002620 Domain of unknown function (DUF427); Region: DUF427; cl00998 233413002621 Uncharacterized conserved protein [Function unknown]; Region: COG3391 233413002622 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 233413002623 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413002624 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 233413002625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413002626 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 233413002627 hydrophobic ligand binding site; other site 233413002628 TIGR03442 family protein; Region: TIGR03442 233413002629 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 233413002630 putative active site [active] 233413002631 putative dimer interface [polypeptide binding]; other site 233413002632 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 233413002633 nucleophile elbow; other site 233413002634 hypothetical protein; Provisional; Region: PRK10279 233413002635 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 233413002636 active site 233413002637 nucleophile elbow; other site 233413002638 Cupin domain; Region: Cupin_2; cl09118 233413002639 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 233413002640 active site residue [active] 233413002641 PE family; Region: PE; pfam00934 233413002642 PE family; Region: PE; pfam00934 233413002643 Predicted membrane protein (DUF2319); Region: DUF2319; cl15412 233413002644 enoyl-CoA hydratase; Provisional; Region: PRK05862 233413002645 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413002646 substrate binding site [chemical binding]; other site 233413002647 oxyanion hole (OAH) forming residues; other site 233413002648 trimer interface [polypeptide binding]; other site 233413002649 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 233413002650 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413002651 substrate binding site [chemical binding]; other site 233413002652 oxyanion hole (OAH) forming residues; other site 233413002653 trimer interface [polypeptide binding]; other site 233413002654 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 233413002655 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 233413002656 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 233413002657 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 233413002658 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 233413002659 dimer interface [polypeptide binding]; other site 233413002660 active site 233413002661 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 233413002662 active site 233413002663 catalytic triad [active] 233413002664 oxyanion hole [active] 233413002665 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 233413002666 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413002667 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 233413002668 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 233413002669 dimer interface [polypeptide binding]; other site 233413002670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413002671 catalytic residue [active] 233413002672 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 233413002673 RDD family; Region: RDD; cl00746 233413002674 cystathionine gamma-synthase; Provisional; Region: PRK07811 233413002675 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 233413002676 homodimer interface [polypeptide binding]; other site 233413002677 substrate-cofactor binding pocket; other site 233413002678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413002679 catalytic residue [active] 233413002680 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 233413002681 domain; Region: GreA_GreB_N; pfam03449 233413002682 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 233413002683 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 233413002684 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 233413002685 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 233413002686 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 233413002687 catalytic residues [active] 233413002688 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 233413002689 Haemolysin-III related; Region: HlyIII; cl03831 233413002690 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 233413002691 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 233413002692 catalytic residue [active] 233413002693 putative FPP diphosphate binding site; other site 233413002694 putative FPP binding hydrophobic cleft; other site 233413002695 dimer interface [polypeptide binding]; other site 233413002696 putative IPP diphosphate binding site; other site 233413002697 PE family; Region: PE; pfam00934 233413002698 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 233413002699 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 233413002700 putative IPP diphosphate binding site; other site 233413002701 PE family; Region: PE; pfam00934 233413002702 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 233413002703 PE family; Region: PE; pfam00934 233413002704 pantothenate kinase; Provisional; Region: PRK05439 233413002705 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 233413002706 ATP-binding site [chemical binding]; other site 233413002707 CoA-binding site [chemical binding]; other site 233413002708 Mg2+-binding site [ion binding]; other site 233413002709 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 233413002710 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 233413002711 dimer interface [polypeptide binding]; other site 233413002712 glycine-pyridoxal phosphate binding site [chemical binding]; other site 233413002713 active site 233413002714 folate binding site [chemical binding]; other site 233413002715 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 233413002716 dinuclear metal binding motif [ion binding]; other site 233413002717 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 233413002718 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 233413002719 putative active site [active] 233413002720 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413002721 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 233413002722 NodB motif; other site 233413002723 active site 233413002724 catalytic site [active] 233413002725 metal binding site [ion binding]; metal-binding site 233413002726 fumarate hydratase; Reviewed; Region: fumC; PRK00485 233413002727 Class II fumarases; Region: Fumarase_classII; cd01362 233413002728 active site 233413002729 tetramer interface [polypeptide binding]; other site 233413002730 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 233413002731 putative active site [active] 233413002732 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 233413002733 Domain of unknown function DUF20; Region: UPF0118; cl00465 233413002734 PemK-like protein; Region: PemK; cl00995 233413002735 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413002736 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413002737 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 233413002738 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 233413002739 putative NAD(P) binding site [chemical binding]; other site 233413002740 active site 233413002741 putative substrate binding site [chemical binding]; other site 233413002742 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 233413002743 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 233413002744 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 233413002745 generic binding surface II; other site 233413002746 generic binding surface I; other site 233413002747 LytB protein; Region: LYTB; cl00507 233413002748 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 233413002749 Yip1 domain; Region: Yip1; cl12048 233413002750 GTP-binding protein YchF; Reviewed; Region: PRK09601 233413002751 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 233413002752 G1 box; other site 233413002753 GTP/Mg2+ binding site [chemical binding]; other site 233413002754 Switch I region; other site 233413002755 G2 box; other site 233413002756 Switch II region; other site 233413002757 G3 box; other site 233413002758 G4 box; other site 233413002759 G5 box; other site 233413002760 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 233413002761 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 233413002762 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413002763 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 233413002764 cyclase homology domain; Region: CHD; cd07302 233413002765 nucleotidyl binding site; other site 233413002766 metal binding site [ion binding]; metal-binding site 233413002767 dimer interface [polypeptide binding]; other site 233413002768 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 233413002769 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 233413002770 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 233413002771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413002772 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 233413002773 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413002774 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413002775 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413002776 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413002777 pyruvate phosphate dikinase; Provisional; Region: PRK05878 233413002778 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 233413002779 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 233413002780 Domain of unknown function DUF222; Region: DUF222; pfam02720 233413002781 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413002782 active site 233413002783 Helix-turn-helix domains; Region: HTH; cl00088 233413002784 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 233413002785 citrate synthase; Provisional; Region: PRK14033 233413002786 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 233413002787 oxalacetate binding site [chemical binding]; other site 233413002788 citrylCoA binding site [chemical binding]; other site 233413002789 coenzyme A binding site [chemical binding]; other site 233413002790 catalytic triad [active] 233413002791 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 233413002792 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 233413002793 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 233413002794 THF binding site; other site 233413002795 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 233413002796 substrate binding site [chemical binding]; other site 233413002797 THF binding site; other site 233413002798 zinc-binding site [ion binding]; other site 233413002799 PPE family; Region: PPE; pfam00823 233413002800 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413002801 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 233413002802 active site 233413002803 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413002804 substrate binding site [chemical binding]; other site 233413002805 oxyanion hole (OAH) forming residues; other site 233413002806 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 233413002807 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 233413002808 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 233413002809 enoyl-CoA hydratase; Provisional; Region: PRK06688 233413002810 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 233413002811 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413002812 trimer interface [polypeptide binding]; other site 233413002813 enoyl-CoA hydratase; Provisional; Region: PRK06688 233413002814 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413002815 substrate binding site [chemical binding]; other site 233413002816 oxyanion hole (OAH) forming residues; other site 233413002817 trimer interface [polypeptide binding]; other site 233413002818 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 233413002819 CoA-transferase family III; Region: CoA_transf_3; pfam02515 233413002820 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 233413002821 NAD binding site [chemical binding]; other site 233413002822 homotetramer interface [polypeptide binding]; other site 233413002823 homodimer interface [polypeptide binding]; other site 233413002824 active site 233413002825 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 233413002826 Domain of unknown function DUF222; Region: DUF222; pfam02720 233413002827 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413002828 active site 233413002829 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 233413002830 Mb1181, -, len: 183 aa. Equivalent to Rv1150, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 183 aa overlap). Possible fragment of transposase (pseudogene). Identical to C-terminal part of S21394 transposase of Mycobacterium tuberculosis IS element (308 aa), FASTA scores: opt: 959, E(): 0, (99.3% identity in 145 aa overlap). The transposase described here may be made by a -1 frame shifting mechanism during translation that fuses Rv1149|MTCI65.16 and Rv1150|MTCI65.17. No evidence found to account for discrepancy with previously published sequence. Second copy is Rv1041c|MTCY10G2.08. TBparse score is 0.914.;POSSIBLE TRANSPOSASE (FRAGMENT) 233413002831 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 233413002832 NAD+ binding site [chemical binding]; other site 233413002833 substrate binding site [chemical binding]; other site 233413002834 Zn binding site [ion binding]; other site 233413002835 Predicted transcriptional regulators [Transcription]; Region: COG1725 233413002836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 233413002837 DNA-binding site [nucleotide binding]; DNA binding site 233413002838 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413002839 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 233413002840 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 233413002841 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 233413002842 minor groove reading motif; other site 233413002843 helix-hairpin-helix signature motif; other site 233413002844 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 233413002845 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 233413002846 aromatic arch; other site 233413002847 DCoH dimer interaction site [polypeptide binding]; other site 233413002848 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 233413002849 DCoH tetramer interaction site [polypeptide binding]; other site 233413002850 substrate binding site [chemical binding]; other site 233413002851 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 233413002852 active site 233413002853 8-oxo-dGMP binding site [chemical binding]; other site 233413002854 nudix motif; other site 233413002855 metal binding site [ion binding]; metal-binding site 233413002856 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 233413002857 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 233413002858 [4Fe-4S] binding site [ion binding]; other site 233413002859 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 233413002860 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 233413002861 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 233413002862 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 233413002863 molybdopterin cofactor binding site; other site 233413002864 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 233413002865 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 233413002866 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 233413002867 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 233413002868 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 233413002869 G1 box; other site 233413002870 putative GEF interaction site [polypeptide binding]; other site 233413002871 GTP/Mg2+ binding site [chemical binding]; other site 233413002872 Switch I region; other site 233413002873 G2 box; other site 233413002874 G3 box; other site 233413002875 Switch II region; other site 233413002876 G4 box; other site 233413002877 G5 box; other site 233413002878 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 233413002879 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 233413002880 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 233413002881 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 233413002882 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413002883 Helix-turn-helix domains; Region: HTH; cl00088 233413002884 Mb1200c, PPE17b, len: 181 aa. Equivalent to 3' end of Rv1168c, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. E332789|Z98268|MTCI125.27C (385 aa), FASTA scores: opt: 504, E(): 0, (36.6% identity in 388 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE17 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits PPE17 into 2 parts, PPE17a and PPE17b.;PPE FAMILY PROTEIN [SECOND PART] 233413002885 PPE family; Region: PPE; pfam00823 233413002886 PE family; Region: PE; pfam00934 233413002887 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 233413002888 PE family; Region: PE; pfam00934 233413002889 FO synthase; Reviewed; Region: fbiC; PRK09234 233413002890 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413002891 FeS/SAM binding site; other site 233413002892 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413002893 FeS/SAM binding site; other site 233413002894 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 233413002895 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 233413002896 active site 233413002897 FMN binding site [chemical binding]; other site 233413002898 2,4-decadienoyl-CoA binding site; other site 233413002899 catalytic residue [active] 233413002900 4Fe-4S cluster binding site [ion binding]; other site 233413002901 Helix-turn-helix domains; Region: HTH; cl00088 233413002902 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 233413002903 Ferredoxin [Energy production and conversion]; Region: COG1146 233413002904 4Fe-4S binding domain; Region: Fer4; cl02805 233413002905 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 233413002906 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 233413002907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413002908 homodimer interface [polypeptide binding]; other site 233413002909 catalytic residue [active] 233413002910 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 233413002911 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413002912 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413002913 ATP binding site [chemical binding]; other site 233413002914 putative Mg++ binding site [ion binding]; other site 233413002915 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 233413002916 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 233413002917 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413002918 active site 233413002919 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413002920 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 233413002921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413002922 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 233413002923 Enoylreductase; Region: PKS_ER; smart00829 233413002924 NAD(P) binding site [chemical binding]; other site 233413002925 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 233413002926 putative NADP binding site [chemical binding]; other site 233413002927 active site 233413002928 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413002929 Condensation domain; Region: Condensation; pfam00668 233413002930 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 233413002931 Cutinase; Region: Cutinase; cl15711 233413002932 acyl-CoA synthetase; Validated; Region: PRK05850 233413002933 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413002934 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 233413002935 Helix-turn-helix domains; Region: HTH; cl00088 233413002936 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 233413002937 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 233413002938 Glutamate binding site [chemical binding]; other site 233413002939 NAD binding site [chemical binding]; other site 233413002940 catalytic residues [active] 233413002941 Proline dehydrogenase; Region: Pro_dh; cl03282 233413002942 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 233413002943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 233413002944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 233413002945 DNA binding residues [nucleotide binding] 233413002946 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413002947 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413002948 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413002949 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413002950 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413002951 acyl-CoA synthetase; Validated; Region: PRK07787 233413002952 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413002953 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 233413002954 PE family; Region: PE; pfam00934 233413002955 PPE family; Region: PPE; pfam00823 233413002956 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413002957 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413002958 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413002959 Transposase, Mutator family; Region: Transposase_mut; pfam00872 233413002960 MULE transposase domain; Region: MULE; pfam10551 233413002961 metabolite-proton symporter; Region: 2A0106; TIGR00883 233413002962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413002963 putative substrate translocation pore; other site 233413002964 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 233413002965 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 233413002966 putative trimer interface [polypeptide binding]; other site 233413002967 putative CoA binding site [chemical binding]; other site 233413002968 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 233413002969 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 233413002970 metal binding site [ion binding]; metal-binding site 233413002971 putative dimer interface [polypeptide binding]; other site 233413002972 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 233413002973 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 233413002974 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 233413002975 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413002976 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 233413002977 dihydropteroate synthase; Region: DHPS; TIGR01496 233413002978 substrate binding pocket [chemical binding]; other site 233413002979 dimer interface [polypeptide binding]; other site 233413002980 inhibitor binding site; inhibition site 233413002981 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 233413002982 active site 233413002983 DivIVA domain; Region: DivI1A_domain; TIGR03544 233413002984 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 233413002985 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 233413002986 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 233413002987 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 233413002988 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 233413002989 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 233413002990 ligand binding site; other site 233413002991 oligomer interface; other site 233413002992 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 233413002993 dimer interface [polypeptide binding]; other site 233413002994 N-terminal domain interface [polypeptide binding]; other site 233413002995 sulfate 1 binding site; other site 233413002996 PE family; Region: PE; pfam00934 233413002997 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 233413002998 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413002999 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 233413003000 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 233413003001 ABC-2 type transporter; Region: ABC2_membrane; cl11417 233413003002 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 233413003003 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 233413003004 Walker A/P-loop; other site 233413003005 ATP binding site [chemical binding]; other site 233413003006 Q-loop/lid; other site 233413003007 ABC transporter signature motif; other site 233413003008 Walker B; other site 233413003009 D-loop; other site 233413003010 H-loop/switch region; other site 233413003011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413003012 Helix-turn-helix domains; Region: HTH; cl00088 233413003013 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 233413003014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413003015 S-adenosylmethionine binding site [chemical binding]; other site 233413003016 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 233413003017 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 233413003018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 233413003019 DNA binding residues [nucleotide binding] 233413003020 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 233413003021 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 233413003022 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 233413003023 protein binding site [polypeptide binding]; other site 233413003024 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 233413003025 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 233413003026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 233413003027 active site 233413003028 motif I; other site 233413003029 motif II; other site 233413003030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 233413003031 Predicted membrane protein [Function unknown]; Region: COG3428 233413003032 Bacterial membrane flanked domain; Region: DUF304; cl01348 233413003033 Bacterial PH domain; Region: DUF304; cl01348 233413003034 Domain of unknown function DUF59; Region: DUF59; cl00941 233413003035 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 233413003036 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 233413003037 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 233413003038 N-acetyl-D-glucosamine binding site [chemical binding]; other site 233413003039 catalytic residue [active] 233413003040 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 233413003041 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 233413003042 MgtE intracellular N domain; Region: MgtE_N; cl15244 233413003043 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 233413003044 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 233413003045 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 233413003046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 233413003047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413003048 dimer interface [polypeptide binding]; other site 233413003049 conserved gate region; other site 233413003050 putative PBP binding loops; other site 233413003051 ABC-ATPase subunit interface; other site 233413003052 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 233413003053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413003054 dimer interface [polypeptide binding]; other site 233413003055 conserved gate region; other site 233413003056 ABC-ATPase subunit interface; other site 233413003057 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 233413003058 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 233413003059 Walker A/P-loop; other site 233413003060 ATP binding site [chemical binding]; other site 233413003061 Q-loop/lid; other site 233413003062 ABC transporter signature motif; other site 233413003063 Walker B; other site 233413003064 D-loop; other site 233413003065 H-loop/switch region; other site 233413003066 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 233413003067 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 233413003068 malate dehydrogenase; Provisional; Region: PRK05442 233413003069 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 233413003070 NAD(P) binding site [chemical binding]; other site 233413003071 dimer interface [polypeptide binding]; other site 233413003072 malate binding site [chemical binding]; other site 233413003073 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413003074 PE family; Region: PE; pfam00934 233413003075 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 233413003076 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 233413003077 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 233413003078 classical (c) SDRs; Region: SDR_c; cd05233 233413003079 NAD(P) binding site [chemical binding]; other site 233413003080 active site 233413003081 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 233413003082 Phd_YefM; Region: PhdYeFM; cl09153 233413003083 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 233413003084 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 233413003085 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 233413003086 TPP-binding site [chemical binding]; other site 233413003087 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 233413003088 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 233413003089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413003090 putative substrate translocation pore; other site 233413003091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413003092 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 233413003093 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 233413003094 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 233413003095 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413003096 Family description; Region: UvrD_C_2; cl15862 233413003097 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 233413003098 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 233413003099 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 233413003100 ATP binding site [chemical binding]; other site 233413003101 Mg++ binding site [ion binding]; other site 233413003102 motif III; other site 233413003103 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 233413003104 nucleotide binding region [chemical binding]; other site 233413003105 ATP-binding site [chemical binding]; other site 233413003106 DbpA RNA binding domain; Region: DbpA; pfam03880 233413003107 OpgC protein; Region: OpgC_C; cl00792 233413003108 Acyltransferase family; Region: Acyl_transf_3; pfam01757 233413003109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413003110 H+ Antiporter protein; Region: 2A0121; TIGR00900 233413003111 putative substrate translocation pore; other site 233413003112 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 233413003113 Fe-S cluster binding site [ion binding]; other site 233413003114 DNA binding site [nucleotide binding] 233413003115 active site 233413003116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413003117 hypothetical protein; Validated; Region: PRK05868 233413003118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413003119 Domain of unknown function (DUF385); Region: DUF385; cl04387 233413003120 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 233413003121 HIT family signature motif; other site 233413003122 catalytic residue [active] 233413003123 amidase; Provisional; Region: PRK12470 233413003124 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 233413003125 cyclase homology domain; Region: CHD; cd07302 233413003126 nucleotidyl binding site; other site 233413003127 metal binding site [ion binding]; metal-binding site 233413003128 dimer interface [polypeptide binding]; other site 233413003129 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 233413003130 Catalytic domain of Protein Kinases; Region: PKc; cd00180 233413003131 active site 233413003132 ATP binding site [chemical binding]; other site 233413003133 substrate binding site [chemical binding]; other site 233413003134 activation loop (A-loop); other site 233413003135 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 233413003136 Helix-turn-helix domains; Region: HTH; cl00088 233413003137 DNA binding site [nucleotide binding] 233413003138 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 233413003139 phosphopeptide binding site; other site 233413003140 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 233413003141 putative active site [active] 233413003142 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 233413003143 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 233413003144 Protein of unknown function (DUF732); Region: DUF732; pfam05305 233413003145 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 233413003146 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 233413003147 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 233413003148 Walker A/P-loop; other site 233413003149 ATP binding site [chemical binding]; other site 233413003150 Q-loop/lid; other site 233413003151 ABC transporter signature motif; other site 233413003152 Walker B; other site 233413003153 D-loop; other site 233413003154 H-loop/switch region; other site 233413003155 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 233413003156 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 233413003157 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413003158 Walker A/P-loop; other site 233413003159 ATP binding site [chemical binding]; other site 233413003160 Q-loop/lid; other site 233413003161 ABC transporter signature motif; other site 233413003162 Walker B; other site 233413003163 D-loop; other site 233413003164 H-loop/switch region; other site 233413003165 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 233413003166 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 233413003167 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 233413003168 catalytic core [active] 233413003169 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 233413003170 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 233413003171 active site 233413003172 metal binding site [ion binding]; metal-binding site 233413003173 DNA binding site [nucleotide binding] 233413003174 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413003175 Uncharacterized conserved protein [Function unknown]; Region: COG4717 233413003176 choline dehydrogenase; Validated; Region: PRK02106 233413003177 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 233413003178 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 233413003179 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 233413003180 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 233413003181 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 233413003182 Walker A/P-loop; other site 233413003183 ATP binding site [chemical binding]; other site 233413003184 Q-loop/lid; other site 233413003185 ABC transporter signature motif; other site 233413003186 Walker B; other site 233413003187 D-loop; other site 233413003188 H-loop/switch region; other site 233413003189 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 233413003190 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 233413003191 Walker A/P-loop; other site 233413003192 ATP binding site [chemical binding]; other site 233413003193 Q-loop/lid; other site 233413003194 ABC transporter signature motif; other site 233413003195 Walker B; other site 233413003196 D-loop; other site 233413003197 H-loop/switch region; other site 233413003198 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 233413003199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413003200 dimer interface [polypeptide binding]; other site 233413003201 conserved gate region; other site 233413003202 putative PBP binding loops; other site 233413003203 ABC-ATPase subunit interface; other site 233413003204 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 233413003205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413003206 dimer interface [polypeptide binding]; other site 233413003207 conserved gate region; other site 233413003208 putative PBP binding loops; other site 233413003209 ABC-ATPase subunit interface; other site 233413003210 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 233413003211 active site clefts [active] 233413003212 zinc binding site [ion binding]; other site 233413003213 dimer interface [polypeptide binding]; other site 233413003214 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 233413003215 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 233413003216 Active Sites [active] 233413003217 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 233413003218 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 233413003219 CysD dimerization site [polypeptide binding]; other site 233413003220 G1 box; other site 233413003221 putative GEF interaction site [polypeptide binding]; other site 233413003222 GTP/Mg2+ binding site [chemical binding]; other site 233413003223 Switch I region; other site 233413003224 G2 box; other site 233413003225 G3 box; other site 233413003226 Switch II region; other site 233413003227 G4 box; other site 233413003228 G5 box; other site 233413003229 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 233413003230 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 233413003231 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413003232 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 233413003233 Walker A/P-loop; other site 233413003234 ligand-binding site [chemical binding]; other site 233413003235 ATP binding site [chemical binding]; other site 233413003236 Rrf2 family protein; Region: rrf2_super; TIGR00738 233413003237 Helix-turn-helix domains; Region: HTH; cl00088 233413003238 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 233413003239 putative peptidoglycan binding site; other site 233413003240 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 233413003241 putative peptidoglycan binding site; other site 233413003242 Putative esterase; Region: Esterase; pfam00756 233413003243 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413003244 Predicted membrane protein [Function unknown]; Region: COG4325 233413003245 Protein of unknown function (DUF732); Region: DUF732; pfam05305 233413003246 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 233413003247 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 233413003248 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 233413003249 active site 233413003250 HIGH motif; other site 233413003251 KMSK motif region; other site 233413003252 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 233413003253 tRNA binding surface [nucleotide binding]; other site 233413003254 anticodon binding site; other site 233413003255 diaminopimelate decarboxylase; Region: lysA; TIGR01048 233413003256 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 233413003257 active site 233413003258 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 233413003259 substrate binding site [chemical binding]; other site 233413003260 catalytic residues [active] 233413003261 dimer interface [polypeptide binding]; other site 233413003262 homoserine dehydrogenase; Provisional; Region: PRK06349 233413003263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413003264 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 233413003265 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 233413003266 threonine synthase; Reviewed; Region: PRK06721 233413003267 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 233413003268 homodimer interface [polypeptide binding]; other site 233413003269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413003270 catalytic residue [active] 233413003271 homoserine kinase; Provisional; Region: PRK01212 233413003272 transcription termination factor Rho; Provisional; Region: PRK12678 233413003273 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 233413003274 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 233413003275 RNA binding site [nucleotide binding]; other site 233413003276 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 233413003277 multimer interface [polypeptide binding]; other site 233413003278 Walker A motif; other site 233413003279 ATP binding site [chemical binding]; other site 233413003280 Walker B motif; other site 233413003281 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 233413003282 peptide chain release factor 1; Region: prfA; TIGR00019 233413003283 RF-1 domain; Region: RF-1; cl02875 233413003284 RF-1 domain; Region: RF-1; cl02875 233413003285 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 233413003286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413003287 S-adenosylmethionine binding site [chemical binding]; other site 233413003288 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 233413003289 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 233413003290 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 233413003291 Mg++ binding site [ion binding]; other site 233413003292 putative catalytic motif [active] 233413003293 substrate binding site [chemical binding]; other site 233413003294 ATP synthase A chain; Region: ATP-synt_A; cl00413 233413003295 ATP synthase subunit C; Region: ATP-synt_C; cl00466 233413003296 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 233413003297 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 233413003298 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 233413003299 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 233413003300 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 233413003301 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 233413003302 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413003303 Walker A motif; other site 233413003304 ATP binding site [chemical binding]; other site 233413003305 Walker B motif; other site 233413003306 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 233413003307 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 233413003308 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 233413003309 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 233413003310 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 233413003311 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 233413003312 alpha subunit interaction interface [polypeptide binding]; other site 233413003313 Walker A motif; other site 233413003314 ATP binding site [chemical binding]; other site 233413003315 Walker B motif; other site 233413003316 inhibitor binding site; inhibition site 233413003317 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 233413003318 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 233413003319 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 233413003320 Transposase; Region: DDE_Tnp_ISL3; pfam01610 233413003321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 233413003322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 233413003323 Transposase; Region: DDE_Tnp_ISL3; pfam01610 233413003324 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 233413003325 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 233413003326 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 233413003327 hinge; other site 233413003328 active site 233413003329 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 233413003330 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 233413003331 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 233413003332 DNA binding site [nucleotide binding] 233413003333 active site 233413003334 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 233413003335 AlkA N-terminal domain; Region: AlkA_N; cl05528 233413003336 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 233413003337 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 233413003338 minor groove reading motif; other site 233413003339 helix-hairpin-helix signature motif; other site 233413003340 substrate binding pocket [chemical binding]; other site 233413003341 active site 233413003342 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 233413003343 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 233413003344 cyclase homology domain; Region: CHD; cd07302 233413003345 nucleotidyl binding site; other site 233413003346 metal binding site [ion binding]; metal-binding site 233413003347 dimer interface [polypeptide binding]; other site 233413003348 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 233413003349 dimerization interface [polypeptide binding]; other site 233413003350 cyclase homology domain; Region: CHD; cd07302 233413003351 nucleotidyl binding site; other site 233413003352 metal binding site [ion binding]; metal-binding site 233413003353 dimer interface [polypeptide binding]; other site 233413003354 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 233413003355 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 233413003356 dimerization interface [polypeptide binding]; other site 233413003357 cyclase homology domain; Region: CHD; cd07302 233413003358 nucleotidyl binding site; other site 233413003359 metal binding site [ion binding]; metal-binding site 233413003360 dimer interface [polypeptide binding]; other site 233413003361 Protein of unknown function DUF91; Region: DUF91; cl00709 233413003362 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 233413003363 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 233413003364 dimer interface [polypeptide binding]; other site 233413003365 substrate binding site [chemical binding]; other site 233413003366 metal binding site [ion binding]; metal-binding site 233413003367 putative acyltransferase; Provisional; Region: PRK05790 233413003368 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 233413003369 dimer interface [polypeptide binding]; other site 233413003370 active site 233413003371 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 233413003372 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 233413003373 PE family; Region: PE; pfam00934 233413003374 glycogen branching enzyme; Provisional; Region: PRK05402 233413003375 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 233413003376 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 233413003377 active site 233413003378 catalytic site [active] 233413003379 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 233413003380 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 233413003381 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 233413003382 active site 233413003383 homodimer interface [polypeptide binding]; other site 233413003384 catalytic site [active] 233413003385 acceptor binding site [chemical binding]; other site 233413003386 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 233413003387 putative homodimer interface [polypeptide binding]; other site 233413003388 putative active site pocket [active] 233413003389 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 233413003390 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 233413003391 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413003392 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413003393 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413003394 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 233413003395 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 233413003396 active site 233413003397 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 233413003398 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 233413003399 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 233413003400 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 233413003401 putative active site pocket [active] 233413003402 cleavage site 233413003403 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 233413003404 MPN+ (JAMM) motif; other site 233413003405 Zinc-binding site [ion binding]; other site 233413003406 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 233413003407 MoaE interaction surface [polypeptide binding]; other site 233413003408 MoeB interaction surface [polypeptide binding]; other site 233413003409 thiocarboxylated glycine; other site 233413003410 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 233413003411 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 233413003412 dimer interface [polypeptide binding]; other site 233413003413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413003414 catalytic residue [active] 233413003415 Rhomboid family; Region: Rhomboid; cl11446 233413003416 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 233413003417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413003418 ribonuclease PH; Reviewed; Region: rph; PRK00173 233413003419 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 233413003420 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 233413003421 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 233413003422 active site 233413003423 dimerization interface [polypeptide binding]; other site 233413003424 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 233413003425 Glucitol operon activator protein (GutM); Region: GutM; cl01890 233413003426 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413003427 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 233413003428 AMP-binding enzyme; Region: AMP-binding; cl15778 233413003429 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 233413003430 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413003431 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413003432 active site 233413003433 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 233413003434 Siderophore biosynthesis protein domain; Region: AlcB; cl11000 233413003435 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 233413003436 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 233413003437 FAD binding pocket [chemical binding]; other site 233413003438 FAD binding motif [chemical binding]; other site 233413003439 phosphate binding motif [ion binding]; other site 233413003440 NAD binding pocket [chemical binding]; other site 233413003441 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 233413003442 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413003443 Walker A/P-loop; other site 233413003444 ATP binding site [chemical binding]; other site 233413003445 Q-loop/lid; other site 233413003446 ABC transporter signature motif; other site 233413003447 Walker B; other site 233413003448 D-loop; other site 233413003449 H-loop/switch region; other site 233413003450 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 233413003451 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413003452 Walker A/P-loop; other site 233413003453 ATP binding site [chemical binding]; other site 233413003454 Q-loop/lid; other site 233413003455 ABC transporter signature motif; other site 233413003456 Walker B; other site 233413003457 D-loop; other site 233413003458 H-loop/switch region; other site 233413003459 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 233413003460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413003461 NAD(P) binding site [chemical binding]; other site 233413003462 active site 233413003463 tetracycline repressor protein TetR; Provisional; Region: PRK13756 233413003464 Helix-turn-helix domains; Region: HTH; cl00088 233413003465 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 233413003466 GAF domain; Region: GAF; cl00853 233413003467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 233413003468 metal binding site [ion binding]; metal-binding site 233413003469 active site 233413003470 I-site; other site 233413003471 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 233413003472 hypothetical protein; Provisional; Region: PRK07877 233413003473 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 233413003474 ATP binding site [chemical binding]; other site 233413003475 substrate interface [chemical binding]; other site 233413003476 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 233413003477 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 233413003478 cyclase homology domain; Region: CHD; cd07302 233413003479 nucleotidyl binding site; other site 233413003480 dimer interface [polypeptide binding]; other site 233413003481 metal binding site [ion binding]; metal-binding site 233413003482 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413003483 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 233413003484 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 233413003485 DNA binding residues [nucleotide binding] 233413003486 dimerization interface [polypeptide binding]; other site 233413003487 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 233413003488 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 233413003489 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 233413003490 PPE family; Region: PPE; pfam00823 233413003491 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413003492 PAS fold; Region: PAS_4; pfam08448 233413003493 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 233413003494 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 233413003495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 233413003496 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 233413003497 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 233413003498 anti sigma factor interaction site; other site 233413003499 regulatory phosphorylation site [posttranslational modification]; other site 233413003500 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 233413003501 synthetase active site [active] 233413003502 NTP binding site [chemical binding]; other site 233413003503 metal binding site [ion binding]; metal-binding site 233413003504 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413003505 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 233413003506 Mb1404, -, len: 317 aa. Similar to 5' end of Rv1371, len: 489 aa, from Mycobacterium tuberculosis strain H37Rv, (90.9% identity in 166 aa overlap). Probable membrane protein. Weak similarity to delta 5 fatty acid desaturases e.g. AB022097|AB022097_1 Dictyostelium discoideum (467 aa), FASTA score: opt: 173, E(): 0.00052, (22.4% identity in 438 aa overlap); and Homo sapiens. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv1371 into 2 parts, Mb1404 and Mb1405, with the latter being the more likely product.;PROBABLE CONSERVED MEMBRANE PROTEIN 233413003507 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 233413003508 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 233413003509 putative di-iron ligands [ion binding]; other site 233413003510 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 233413003511 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 233413003512 malonyl-CoA binding site [chemical binding]; other site 233413003513 dimer interface [polypeptide binding]; other site 233413003514 active site 233413003515 product binding site; other site 233413003516 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 233413003517 Mb1408, -, len: 172 aa. Equivalent to the 3' end of Rv1373, len: 326 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 172 aa overlap). Glycolipid sulfotransferase (EC 2.8.2.-) (see citation below); slight similarity to sulfotransferases e.g. SUOE_CAVPO|P49887 estrogen sulfotransferase from Cavia porcellus (Guinea pig) (EC 2.8.2.4) (296 aa), FASTA scores, opt: 165, E():0.00054, (24.5% identity in 294 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits Rv1373 into 2 parts, Mb1407 and Mb1408.;GLYCOLIPID SULFOTRANSFERASE [SECOND PART] 233413003518 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 233413003519 YcaO-like family; Region: YcaO; cl09146 233413003520 Uncharacterized conserved protein [Function unknown]; Region: COG3482 233413003521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413003522 S-adenosylmethionine binding site [chemical binding]; other site 233413003523 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413003524 active site 233413003525 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 233413003526 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 233413003527 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 233413003528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413003529 dihydroorotase; Validated; Region: pyrC; PRK09357 233413003530 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 233413003531 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 233413003532 active site 233413003533 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 233413003534 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 233413003535 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 233413003536 catalytic site [active] 233413003537 subunit interface [polypeptide binding]; other site 233413003538 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 233413003539 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 233413003540 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 233413003541 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 233413003542 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 233413003543 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 233413003544 IMP binding site; other site 233413003545 dimer interface [polypeptide binding]; other site 233413003546 interdomain contacts; other site 233413003547 partial ornithine binding site; other site 233413003548 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 233413003549 active site 233413003550 dimer interface [polypeptide binding]; other site 233413003551 PE family; Region: PE; pfam00934 233413003552 PPE family; Region: PPE; pfam00823 233413003553 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 233413003554 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 233413003555 catalytic site [active] 233413003556 G-X2-G-X-G-K; other site 233413003557 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 233413003558 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 233413003559 Flavoprotein; Region: Flavoprotein; cl08021 233413003560 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 233413003561 S-adenosylmethionine synthetase; Validated; Region: PRK05250 233413003562 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 233413003563 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 233413003564 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 233413003565 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 233413003566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413003567 Cytochrome P450; Region: p450; cl12078 233413003568 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 233413003569 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 233413003570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 233413003571 PE family; Region: PE; pfam00934 233413003572 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 233413003573 oligomeric interface; other site 233413003574 putative active site [active] 233413003575 homodimer interface [polypeptide binding]; other site 233413003576 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 233413003577 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413003578 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 233413003579 substrate binding pocket [chemical binding]; other site 233413003580 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413003581 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 233413003582 substrate binding pocket [chemical binding]; other site 233413003583 YhhN-like protein; Region: YhhN; cl01505 233413003584 primosome assembly protein PriA; Provisional; Region: PRK14873 233413003585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413003586 S-adenosylmethionine binding site [chemical binding]; other site 233413003587 Helix-turn-helix domains; Region: HTH; cl00088 233413003588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413003589 S-adenosylmethionine binding site [chemical binding]; other site 233413003590 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 233413003591 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 233413003592 putative active site [active] 233413003593 substrate binding site [chemical binding]; other site 233413003594 putative cosubstrate binding site; other site 233413003595 catalytic site [active] 233413003596 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 233413003597 substrate binding site [chemical binding]; other site 233413003598 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 233413003599 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 233413003600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413003601 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 233413003602 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 233413003603 substrate binding site [chemical binding]; other site 233413003604 hexamer interface [polypeptide binding]; other site 233413003605 metal binding site [ion binding]; metal-binding site 233413003606 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 233413003607 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 233413003608 catalytic motif [active] 233413003609 Zn binding site [ion binding]; other site 233413003610 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 233413003611 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 233413003612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413003613 putative substrate translocation pore; other site 233413003614 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 233413003615 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 233413003616 Lumazine binding domain; Region: Lum_binding; pfam00677 233413003617 Lumazine binding domain; Region: Lum_binding; pfam00677 233413003618 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 233413003619 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 233413003620 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 233413003621 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 233413003622 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 233413003623 dimerization interface [polypeptide binding]; other site 233413003624 active site 233413003625 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 233413003626 homopentamer interface [polypeptide binding]; other site 233413003627 active site 233413003628 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 233413003629 PknH-like extracellular domain; Region: PknH_C; pfam14032 233413003630 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 233413003631 putative sugar binding sites [chemical binding]; other site 233413003632 Q-X-W motif; other site 233413003633 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 233413003634 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 233413003635 GIY-YIG motif/motif A; other site 233413003636 active site 233413003637 catalytic site [active] 233413003638 putative DNA binding site [nucleotide binding]; other site 233413003639 metal binding site [ion binding]; metal-binding site 233413003640 UvrB/uvrC motif; Region: UVR; pfam02151 233413003641 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 233413003642 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 233413003643 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 233413003644 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413003645 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 233413003646 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 233413003647 phosphate binding site [ion binding]; other site 233413003648 putative substrate binding pocket [chemical binding]; other site 233413003649 dimer interface [polypeptide binding]; other site 233413003650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 233413003651 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 233413003652 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413003653 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413003654 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413003655 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 233413003656 substrate binding pocket [chemical binding]; other site 233413003657 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413003658 acyl-CoA synthetase; Provisional; Region: PRK13382 233413003659 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413003660 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 233413003661 putative acyl-acceptor binding pocket; other site 233413003662 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 233413003663 PE family; Region: PE; pfam00934 233413003664 Cutinase; Region: Cutinase; cl15711 233413003665 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 233413003666 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 233413003667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413003668 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 233413003669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413003670 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 233413003671 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 233413003672 Phosphoglycerate kinase; Region: PGK; pfam00162 233413003673 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 233413003674 substrate binding site [chemical binding]; other site 233413003675 hinge regions; other site 233413003676 ADP binding site [chemical binding]; other site 233413003677 catalytic site [active] 233413003678 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 233413003679 substrate binding site [chemical binding]; other site 233413003680 dimer interface [polypeptide binding]; other site 233413003681 catalytic triad [active] 233413003682 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 233413003683 PE family; Region: PE; pfam00934 233413003684 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 233413003685 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 233413003686 molybdopterin cofactor binding site [chemical binding]; other site 233413003687 substrate binding site [chemical binding]; other site 233413003688 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 233413003689 molybdopterin cofactor binding site; other site 233413003690 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 233413003691 hydrophobic ligand binding site; other site 233413003692 Filoviridae VP35; Region: Filo_VP35; pfam02097 233413003693 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 233413003694 putative active site [active] 233413003695 opcA protein; Region: OpcA; TIGR00534 233413003696 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 233413003697 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 233413003698 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 233413003699 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 233413003700 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 233413003701 putative active site [active] 233413003702 transaldolase; Provisional; Region: PRK03903 233413003703 catalytic residue [active] 233413003704 transketolase; Reviewed; Region: PRK05899 233413003705 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 233413003706 TPP-binding site [chemical binding]; other site 233413003707 dimer interface [polypeptide binding]; other site 233413003708 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 233413003709 PYR/PP interface [polypeptide binding]; other site 233413003710 dimer interface [polypeptide binding]; other site 233413003711 TPP binding site [chemical binding]; other site 233413003712 PE family; Region: PE; pfam00934 233413003713 UbiA prenyltransferase family; Region: UbiA; cl00337 233413003714 PE family; Region: PE; pfam00934 233413003715 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 233413003716 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 233413003717 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 233413003718 NADP binding site [chemical binding]; other site 233413003719 dimer interface [polypeptide binding]; other site 233413003720 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 233413003721 ABC-2 type transporter; Region: ABC2_membrane; cl11417 233413003722 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 233413003723 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 233413003724 Walker A/P-loop; other site 233413003725 ATP binding site [chemical binding]; other site 233413003726 Q-loop/lid; other site 233413003727 ABC transporter signature motif; other site 233413003728 Walker B; other site 233413003729 D-loop; other site 233413003730 H-loop/switch region; other site 233413003731 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 233413003732 Predicted transcriptional regulator [Transcription]; Region: COG2345 233413003733 Helix-turn-helix domains; Region: HTH; cl00088 233413003734 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 233413003735 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 233413003736 thioester formation/cholesterol transfer; other site 233413003737 protein-splicing catalytic site; other site 233413003738 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 233413003739 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 233413003740 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 233413003741 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 233413003742 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 233413003743 FeS assembly ATPase SufC; Region: sufC; TIGR01978 233413003744 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 233413003745 Walker A/P-loop; other site 233413003746 ATP binding site [chemical binding]; other site 233413003747 Q-loop/lid; other site 233413003748 ABC transporter signature motif; other site 233413003749 Walker B; other site 233413003750 D-loop; other site 233413003751 H-loop/switch region; other site 233413003752 Aminotransferase class-V; Region: Aminotran_5; pfam00266 233413003753 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 233413003754 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413003755 catalytic residue [active] 233413003756 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 233413003757 trimerization site [polypeptide binding]; other site 233413003758 active site 233413003759 Domain of unknown function DUF59; Region: DUF59; cl00941 233413003760 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 233413003761 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 233413003762 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413003763 active site 233413003764 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 233413003765 PE family; Region: PE; pfam00934 233413003766 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 233413003767 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 233413003768 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 233413003769 catalytic residues [active] 233413003770 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 233413003771 catalytic residues [active] 233413003772 enoyl-CoA hydratase; Provisional; Region: PRK05864 233413003773 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413003774 substrate binding site [chemical binding]; other site 233413003775 oxyanion hole (OAH) forming residues; other site 233413003776 trimer interface [polypeptide binding]; other site 233413003777 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 233413003778 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413003779 Walker A/P-loop; other site 233413003780 ATP binding site [chemical binding]; other site 233413003781 Q-loop/lid; other site 233413003782 ABC transporter signature motif; other site 233413003783 Walker B; other site 233413003784 D-loop; other site 233413003785 H-loop/switch region; other site 233413003786 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 233413003787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413003788 Helix-turn-helix domains; Region: HTH; cl00088 233413003789 aconitate hydratase; Validated; Region: PRK09277 233413003790 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 233413003791 substrate binding site [chemical binding]; other site 233413003792 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 233413003793 ligand binding site [chemical binding]; other site 233413003794 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 233413003795 substrate binding site [chemical binding]; other site 233413003796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 233413003797 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 233413003798 NlpC/P60 family; Region: NLPC_P60; cl11438 233413003799 NlpC/P60 family; Region: NLPC_P60; cl11438 233413003800 MoxR-like ATPases [General function prediction only]; Region: COG0714 233413003801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413003802 Walker A motif; other site 233413003803 ATP binding site [chemical binding]; other site 233413003804 Walker B motif; other site 233413003805 arginine finger; other site 233413003806 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 233413003807 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 233413003808 hypothetical protein; Provisional; Region: PRK13685 233413003809 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 233413003810 metal ion-dependent adhesion site (MIDAS); other site 233413003811 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 233413003812 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 233413003813 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 233413003814 NAD(P) binding site [chemical binding]; other site 233413003815 homotetramer interface [polypeptide binding]; other site 233413003816 homodimer interface [polypeptide binding]; other site 233413003817 active site 233413003818 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 233413003819 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 233413003820 NAD binding site [chemical binding]; other site 233413003821 homotetramer interface [polypeptide binding]; other site 233413003822 homodimer interface [polypeptide binding]; other site 233413003823 substrate binding site [chemical binding]; other site 233413003824 active site 233413003825 ferrochelatase; Reviewed; Region: hemH; PRK00035 233413003826 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 233413003827 C-terminal domain interface [polypeptide binding]; other site 233413003828 active site 233413003829 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 233413003830 active site 233413003831 N-terminal domain interface [polypeptide binding]; other site 233413003832 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 233413003833 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 233413003834 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 233413003835 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 233413003836 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 233413003837 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 233413003838 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 233413003839 heterodimer interface [polypeptide binding]; other site 233413003840 substrate interaction site [chemical binding]; other site 233413003841 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 233413003842 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 233413003843 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 233413003844 active site 233413003845 substrate binding site [chemical binding]; other site 233413003846 coenzyme B12 binding site [chemical binding]; other site 233413003847 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 233413003848 B12 binding site [chemical binding]; other site 233413003849 cobalt ligand [ion binding]; other site 233413003850 PemK-like protein; Region: PemK; cl00995 233413003851 membrane ATPase/protein kinase; Provisional; Region: PRK09435 233413003852 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 233413003853 Walker A; other site 233413003854 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 233413003855 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413003856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413003857 S-adenosylmethionine binding site [chemical binding]; other site 233413003858 Protein of unknown function (DUF1458); Region: DUF1458; cl01328 233413003859 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 233413003860 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 233413003861 Ligand binding site; other site 233413003862 Putative Catalytic site; other site 233413003863 DXD motif; other site 233413003864 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 233413003865 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 233413003866 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 233413003867 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 233413003868 inhibitor-cofactor binding pocket; inhibition site 233413003869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413003870 catalytic residue [active] 233413003871 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 233413003872 putative trimer interface [polypeptide binding]; other site 233413003873 putative CoA binding site [chemical binding]; other site 233413003874 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 233413003875 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 233413003876 active site 233413003877 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 233413003878 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 233413003879 active site 233413003880 acyl-CoA synthetase; Validated; Region: PRK05850 233413003881 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413003882 Transport protein; Region: actII; TIGR00833 233413003883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413003884 S-adenosylmethionine binding site [chemical binding]; other site 233413003885 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 233413003886 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 233413003887 homodimer interface [polypeptide binding]; other site 233413003888 active site 233413003889 TDP-binding site; other site 233413003890 acceptor substrate-binding pocket; other site 233413003891 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 233413003892 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 233413003893 Probable Catalytic site; other site 233413003894 metal-binding site 233413003895 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 233413003896 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 233413003897 homodimer interface [polypeptide binding]; other site 233413003898 active site 233413003899 TDP-binding site; other site 233413003900 acceptor substrate-binding pocket; other site 233413003901 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 233413003902 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413003903 active site 233413003904 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413003905 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 233413003906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413003907 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 233413003908 Enoylreductase; Region: PKS_ER; smart00829 233413003909 NAD(P) binding site [chemical binding]; other site 233413003910 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 233413003911 putative NADP binding site [chemical binding]; other site 233413003912 active site 233413003913 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413003914 acyl-CoA synthetase; Validated; Region: PRK05850 233413003915 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413003916 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 233413003917 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 233413003918 NAD(P) binding site [chemical binding]; other site 233413003919 Uncharacterized conserved protein [Function unknown]; Region: COG2128 233413003920 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 233413003921 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 233413003922 CoenzymeA binding site [chemical binding]; other site 233413003923 subunit interaction site [polypeptide binding]; other site 233413003924 PHB binding site; other site 233413003925 Nitronate monooxygenase; Region: NMO; pfam03060 233413003926 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 233413003927 FMN binding site [chemical binding]; other site 233413003928 substrate binding site [chemical binding]; other site 233413003929 putative catalytic residue [active] 233413003930 transcriptional regulator BetI; Validated; Region: PRK00767 233413003931 Helix-turn-helix domains; Region: HTH; cl00088 233413003932 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 233413003933 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 233413003934 HIGH motif; other site 233413003935 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 233413003936 active site 233413003937 KMSKS motif; other site 233413003938 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 233413003939 tRNA binding surface [nucleotide binding]; other site 233413003940 anticodon binding site; other site 233413003941 DNA polymerase IV; Provisional; Region: PRK03348 233413003942 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 233413003943 active site 233413003944 DNA binding site [nucleotide binding] 233413003945 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 233413003946 active site 233413003947 homodimer interface [polypeptide binding]; other site 233413003948 homotetramer interface [polypeptide binding]; other site 233413003949 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 233413003950 lipoprotein signal peptidase; Provisional; Region: PRK14787 233413003951 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 233413003952 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 233413003953 active site 233413003954 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 233413003955 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 233413003956 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 233413003957 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 233413003958 apolar tunnel; other site 233413003959 heme binding site [chemical binding]; other site 233413003960 dimerization interface [polypeptide binding]; other site 233413003961 short chain dehydrogenase; Provisional; Region: PRK05866 233413003962 classical (c) SDRs; Region: SDR_c; cd05233 233413003963 NAD(P) binding site [chemical binding]; other site 233413003964 active site 233413003965 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 233413003966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413003967 NAD(P) binding site [chemical binding]; other site 233413003968 active site 233413003969 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 233413003970 hydrophobic ligand binding site; other site 233413003971 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 233413003972 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 233413003973 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 233413003974 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 233413003975 generic binding surface II; other site 233413003976 generic binding surface I; other site 233413003977 PPE family; Region: PPE; pfam00823 233413003978 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413003979 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413003980 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 233413003981 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413003982 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 233413003983 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 233413003984 putative acyl-acceptor binding pocket; other site 233413003985 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 233413003986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413003987 domain; Region: Succ_DH_flav_C; pfam02910 233413003988 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 233413003989 4Fe-4S binding domain; Region: Fer4; cl02805 233413003990 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 233413003991 D-subunit interface [polypeptide binding]; other site 233413003992 Iron-sulfur protein interface; other site 233413003993 proximal quinone binding site [chemical binding]; other site 233413003994 distal quinone binding site [chemical binding]; other site 233413003995 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 233413003996 Iron-sulfur protein interface; other site 233413003997 proximal quinone binding site [chemical binding]; other site 233413003998 C-subunit interface; other site 233413003999 distal quinone binding site; other site 233413004000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413004001 Helix-turn-helix domains; Region: HTH; cl00088 233413004002 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 233413004003 Transport protein; Region: actII; TIGR00833 233413004004 Domain of unknown function (DUF385); Region: DUF385; cl04387 233413004005 threonine dehydratase; Validated; Region: PRK08639 233413004006 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 233413004007 tetramer interface [polypeptide binding]; other site 233413004008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413004009 catalytic residue [active] 233413004010 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 233413004011 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 233413004012 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 233413004013 putative active site [active] 233413004014 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 233413004015 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 233413004016 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 233413004017 catalytic site [active] 233413004018 active site 233413004019 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 233413004020 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 233413004021 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 233413004022 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 233413004023 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 233413004024 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 233413004025 active site 233413004026 catalytic site [active] 233413004027 OpgC protein; Region: OpgC_C; cl00792 233413004028 Acyltransferase family; Region: Acyl_transf_3; pfam01757 233413004029 NlpC/P60 family; Region: NLPC_P60; cl11438 233413004030 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 233413004031 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 233413004032 inhibitor-cofactor binding pocket; inhibition site 233413004033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413004034 catalytic residue [active] 233413004035 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 233413004036 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 233413004037 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413004038 catalytic residue [active] 233413004039 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413004040 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 233413004041 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 233413004042 Phage capsid family; Region: Phage_capsid; pfam05065 233413004043 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 233413004044 Phage terminase, small subunit; Region: Terminase_4; cl01525 233413004045 Phage associated DNA primase [General function prediction only]; Region: COG3378 233413004046 D5 N terminal like; Region: D5_N; cl07360 233413004047 Poxvirus D5 protein-like; Region: Pox_D5; cl15708 233413004048 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 233413004049 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 233413004050 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 233413004051 catalytic residues [active] 233413004052 catalytic nucleophile [active] 233413004053 Recombinase; Region: Recombinase; pfam07508 233413004054 Domain of unknown function DUF222; Region: DUF222; pfam02720 233413004055 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413004056 active site 233413004057 Domain of unknown function (DUF222); Region: DUF222; pfam02720 233413004058 biotin synthase; Validated; Region: PRK06256 233413004059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413004060 FeS/SAM binding site; other site 233413004061 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 233413004062 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 233413004063 Secretory lipase; Region: LIP; pfam03583 233413004064 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 233413004065 nudix motif; other site 233413004066 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 233413004067 Quinolinate synthetase A protein; Region: NadA; cl00420 233413004068 L-aspartate oxidase; Provisional; Region: PRK07804 233413004069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413004070 domain; Region: Succ_DH_flav_C; pfam02910 233413004071 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 233413004072 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 233413004073 dimerization interface [polypeptide binding]; other site 233413004074 active site 233413004075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413004076 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 233413004077 Domain of unknown function (DUF385); Region: DUF385; cl04387 233413004078 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 233413004079 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 233413004080 NAD binding site [chemical binding]; other site 233413004081 dimerization interface [polypeptide binding]; other site 233413004082 product binding site; other site 233413004083 substrate binding site [chemical binding]; other site 233413004084 zinc binding site [ion binding]; other site 233413004085 catalytic residues [active] 233413004086 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 233413004087 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 233413004088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413004089 homodimer interface [polypeptide binding]; other site 233413004090 catalytic residue [active] 233413004091 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 233413004092 4-fold oligomerization interface [polypeptide binding]; other site 233413004093 putative active site pocket [active] 233413004094 metal binding residues [ion binding]; metal-binding site 233413004095 3-fold/trimer interface [polypeptide binding]; other site 233413004096 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 233413004097 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 233413004098 putative active site [active] 233413004099 oxyanion strand; other site 233413004100 catalytic triad [active] 233413004101 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 233413004102 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 233413004103 catalytic residues [active] 233413004104 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 233413004105 active site 233413004106 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 233413004107 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 233413004108 substrate binding site [chemical binding]; other site 233413004109 glutamase interaction surface [polypeptide binding]; other site 233413004110 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 233413004111 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 233413004112 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 233413004113 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 233413004114 catalytic triad [active] 233413004115 anthranilate synthase component I; Provisional; Region: PRK13571 233413004116 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 233413004117 chorismate binding enzyme; Region: Chorismate_bind; cl10555 233413004118 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 233413004119 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 233413004120 active site 233413004121 ribulose/triose binding site [chemical binding]; other site 233413004122 phosphate binding site [ion binding]; other site 233413004123 substrate (anthranilate) binding pocket [chemical binding]; other site 233413004124 product (indole) binding pocket [chemical binding]; other site 233413004125 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 233413004126 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 233413004127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413004128 catalytic residue [active] 233413004129 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 233413004130 substrate binding site [chemical binding]; other site 233413004131 active site 233413004132 catalytic residues [active] 233413004133 heterodimer interface [polypeptide binding]; other site 233413004134 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 233413004135 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 233413004136 TM2 domain; Region: TM2; cl00984 233413004137 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 233413004138 pyruvate kinase; Provisional; Region: PRK06247 233413004139 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 233413004140 domain interfaces; other site 233413004141 active site 233413004142 acyl-CoA thioesterase II; Region: tesB; TIGR00189 233413004143 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 233413004144 active site 233413004145 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 233413004146 catalytic triad [active] 233413004147 dimer interface [polypeptide binding]; other site 233413004148 Uncharacterized conserved protein [Function unknown]; Region: COG2898 233413004149 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 233413004150 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 233413004151 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413004152 Walker A/P-loop; other site 233413004153 ATP binding site [chemical binding]; other site 233413004154 Q-loop/lid; other site 233413004155 ABC transporter signature motif; other site 233413004156 Walker B; other site 233413004157 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 233413004158 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413004159 Walker A/P-loop; other site 233413004160 ATP binding site [chemical binding]; other site 233413004161 Q-loop/lid; other site 233413004162 ABC transporter signature motif; other site 233413004163 Walker B; other site 233413004164 D-loop; other site 233413004165 H-loop/switch region; other site 233413004166 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 233413004167 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 233413004168 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 233413004169 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 233413004170 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 233413004171 cyclase homology domain; Region: CHD; cd07302 233413004172 nucleotidyl binding site; other site 233413004173 metal binding site [ion binding]; metal-binding site 233413004174 dimer interface [polypeptide binding]; other site 233413004175 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 233413004176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 233413004177 active site 233413004178 phosphorylation site [posttranslational modification] 233413004179 intermolecular recognition site; other site 233413004180 dimerization interface [polypeptide binding]; other site 233413004181 ANTAR domain; Region: ANTAR; cl04297 233413004182 lipid-transfer protein; Provisional; Region: PRK06059 233413004183 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 233413004184 active site 233413004185 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 233413004186 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 233413004187 DUF35 OB-fold domain; Region: DUF35; pfam01796 233413004188 DNA polymerase I; Provisional; Region: PRK05755 233413004189 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 233413004190 active site 233413004191 metal binding site 1 [ion binding]; metal-binding site 233413004192 putative 5' ssDNA interaction site; other site 233413004193 metal binding site 3; metal-binding site 233413004194 metal binding site 2 [ion binding]; metal-binding site 233413004195 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 233413004196 putative DNA binding site [nucleotide binding]; other site 233413004197 putative metal binding site [ion binding]; other site 233413004198 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 233413004199 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 233413004200 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 233413004201 active site 233413004202 DNA binding site [nucleotide binding] 233413004203 catalytic site [active] 233413004204 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 233413004205 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 233413004206 RNA binding site [nucleotide binding]; other site 233413004207 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 233413004208 RNA binding site [nucleotide binding]; other site 233413004209 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 233413004210 RNA binding site [nucleotide binding]; other site 233413004211 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 233413004212 RNA binding site [nucleotide binding]; other site 233413004213 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 233413004214 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 233413004215 CoA-binding site [chemical binding]; other site 233413004216 ATP-binding [chemical binding]; other site 233413004217 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 233413004218 Protein of unknown function (DUF402); Region: DUF402; cl00979 233413004219 excinuclease ABC subunit B; Provisional; Region: PRK05298 233413004220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 233413004221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 233413004222 nucleotide binding region [chemical binding]; other site 233413004223 ATP-binding site [chemical binding]; other site 233413004224 Ultra-violet resistance protein B; Region: UvrB; pfam12344 233413004225 UvrB/uvrC motif; Region: UVR; pfam02151 233413004226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413004227 putative substrate translocation pore; other site 233413004228 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 233413004229 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 233413004230 Ligand Binding Site [chemical binding]; other site 233413004231 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413004232 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 233413004233 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 233413004234 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 233413004235 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 233413004236 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 233413004237 Predicted esterase [General function prediction only]; Region: COG0627 233413004238 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413004239 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 233413004240 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 233413004241 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 233413004242 dimer interface [polypeptide binding]; other site 233413004243 putative anticodon binding site; other site 233413004244 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 233413004245 motif 1; other site 233413004246 dimer interface [polypeptide binding]; other site 233413004247 active site 233413004248 motif 2; other site 233413004249 motif 3; other site 233413004250 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 233413004251 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 233413004252 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 233413004253 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 233413004254 ribosomal protein L20; Region: rpl20; CHL00068 233413004255 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 233413004256 23S rRNA binding site [nucleotide binding]; other site 233413004257 L21 binding site [polypeptide binding]; other site 233413004258 L13 binding site [polypeptide binding]; other site 233413004259 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 233413004260 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 233413004261 PE family; Region: PE; pfam00934 233413004262 cyclase homology domain; Region: CHD; cd07302 233413004263 nucleotidyl binding site; other site 233413004264 metal binding site [ion binding]; metal-binding site 233413004265 dimer interface [polypeptide binding]; other site 233413004266 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 233413004267 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 233413004268 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 233413004269 dimer interface [polypeptide binding]; other site 233413004270 motif 1; other site 233413004271 active site 233413004272 motif 2; other site 233413004273 motif 3; other site 233413004274 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 233413004275 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 233413004276 putative tRNA-binding site [nucleotide binding]; other site 233413004277 B3/4 domain; Region: B3_4; cl11458 233413004278 tRNA synthetase B5 domain; Region: B5; cl08394 233413004279 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 233413004280 dimer interface [polypeptide binding]; other site 233413004281 motif 1; other site 233413004282 motif 3; other site 233413004283 motif 2; other site 233413004284 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 233413004285 PE family; Region: PE; pfam00934 233413004286 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 233413004287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413004288 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 233413004289 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 233413004290 heterotetramer interface [polypeptide binding]; other site 233413004291 active site pocket [active] 233413004292 cleavage site 233413004293 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 233413004294 feedback inhibition sensing region; other site 233413004295 homohexameric interface [polypeptide binding]; other site 233413004296 nucleotide binding site [chemical binding]; other site 233413004297 N-acetyl-L-glutamate binding site [chemical binding]; other site 233413004298 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 233413004299 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 233413004300 inhibitor-cofactor binding pocket; inhibition site 233413004301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413004302 catalytic residue [active] 233413004303 ornithine carbamoyltransferase; Provisional; Region: PRK00779 233413004304 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 233413004305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413004306 arginine repressor; Provisional; Region: PRK03341 233413004307 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 233413004308 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 233413004309 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 233413004310 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 233413004311 ANP binding site [chemical binding]; other site 233413004312 Substrate Binding Site II [chemical binding]; other site 233413004313 Substrate Binding Site I [chemical binding]; other site 233413004314 argininosuccinate lyase; Provisional; Region: PRK00855 233413004315 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 233413004316 active sites [active] 233413004317 tetramer interface [polypeptide binding]; other site 233413004318 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 233413004319 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 233413004320 malonyl-CoA binding site [chemical binding]; other site 233413004321 dimer interface [polypeptide binding]; other site 233413004322 active site 233413004323 product binding site; other site 233413004324 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 233413004325 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413004326 active site 233413004327 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413004328 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 233413004329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413004330 Enoylreductase; Region: PKS_ER; smart00829 233413004331 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 233413004332 NAD(P) binding site [chemical binding]; other site 233413004333 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 233413004334 putative NADP binding site [chemical binding]; other site 233413004335 active site 233413004336 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413004337 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 233413004338 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413004339 active site 233413004340 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413004341 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 233413004342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413004343 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 233413004344 NAD(P) binding site [chemical binding]; other site 233413004345 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 233413004346 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 233413004347 putative NADP binding site [chemical binding]; other site 233413004348 active site 233413004349 acyl-CoA synthetase; Validated; Region: PRK06060 233413004350 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413004351 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 233413004352 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413004353 active site 233413004354 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 233413004355 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413004356 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413004357 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 233413004358 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 233413004359 malonyl-CoA binding site [chemical binding]; other site 233413004360 dimer interface [polypeptide binding]; other site 233413004361 active site 233413004362 product binding site; other site 233413004363 Cytochrome P450; Region: p450; cl12078 233413004364 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 233413004365 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 233413004366 ABC transporter; Region: ABC_tran_2; pfam12848 233413004367 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 233413004368 Domain of unknown function (DUF427); Region: DUF427; cl00998 233413004369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413004370 putative substrate translocation pore; other site 233413004371 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 233413004372 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 233413004373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 233413004374 dimerization interface [polypeptide binding]; other site 233413004375 putative DNA binding site [nucleotide binding]; other site 233413004376 putative Zn2+ binding site [ion binding]; other site 233413004377 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 233413004378 active site residue [active] 233413004379 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 233413004380 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 233413004381 ligand binding site [chemical binding]; other site 233413004382 flexible hinge region; other site 233413004383 Helix-turn-helix domains; Region: HTH; cl00088 233413004384 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 233413004385 putative catalytic residues [active] 233413004386 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 233413004387 catalytic residues [active] 233413004388 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413004389 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413004390 active site 233413004391 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 233413004392 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413004393 FeS/SAM binding site; other site 233413004394 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 233413004395 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 233413004396 acyl-CoA synthetase; Validated; Region: PRK07868 233413004397 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 233413004398 AMP-binding enzyme; Region: AMP-binding; cl15778 233413004399 Trm112p-like protein; Region: Trm112p; cl01066 233413004400 Helix-turn-helix domains; Region: HTH; cl00088 233413004401 ABC-2 type transporter; Region: ABC2_membrane; cl11417 233413004402 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 233413004403 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 233413004404 Walker A/P-loop; other site 233413004405 ATP binding site [chemical binding]; other site 233413004406 Q-loop/lid; other site 233413004407 ABC transporter signature motif; other site 233413004408 Walker B; other site 233413004409 D-loop; other site 233413004410 H-loop/switch region; other site 233413004411 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 233413004412 active site 233413004413 DNA binding site [nucleotide binding] 233413004414 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 233413004415 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 233413004416 active site 233413004417 HIGH motif; other site 233413004418 dimer interface [polypeptide binding]; other site 233413004419 KMSKS motif; other site 233413004420 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 233413004421 Protein of unknown function (DUF732); Region: DUF732; pfam05305 233413004422 Tetratrico peptide repeat; Region: TPR_5; pfam12688 233413004423 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 233413004424 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413004425 active site 233413004426 motif I; other site 233413004427 motif II; other site 233413004428 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413004429 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 233413004430 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 233413004431 RNA binding surface [nucleotide binding]; other site 233413004432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413004433 S-adenosylmethionine binding site [chemical binding]; other site 233413004434 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 233413004435 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 233413004436 DNA repair protein RecN; Region: recN; TIGR00634 233413004437 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 233413004438 Walker A/P-loop; other site 233413004439 ATP binding site [chemical binding]; other site 233413004440 Q-loop/lid; other site 233413004441 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 233413004442 Q-loop/lid; other site 233413004443 ABC transporter signature motif; other site 233413004444 Walker B; other site 233413004445 D-loop; other site 233413004446 H-loop/switch region; other site 233413004447 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 233413004448 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 233413004449 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 233413004450 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 233413004451 CTP synthetase; Validated; Region: pyrG; PRK05380 233413004452 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 233413004453 Catalytic site [active] 233413004454 active site 233413004455 UTP binding site [chemical binding]; other site 233413004456 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 233413004457 active site 233413004458 putative oxyanion hole; other site 233413004459 catalytic triad [active] 233413004460 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 233413004461 dimer interface [polypeptide binding]; other site 233413004462 ADP-ribose binding site [chemical binding]; other site 233413004463 active site 233413004464 nudix motif; other site 233413004465 metal binding site [ion binding]; metal-binding site 233413004466 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 233413004467 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 233413004468 DNA binding site [nucleotide binding] 233413004469 Int/Topo IB signature motif; other site 233413004470 active site 233413004471 Domain of unknown function (DUF222); Region: DUF222; pfam02720 233413004472 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413004473 active site 233413004474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413004475 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 233413004476 PPE family; Region: PPE; pfam00823 233413004477 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413004478 PPE family; Region: PPE; pfam00823 233413004479 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413004480 Permease family; Region: Xan_ur_permease; cl00967 233413004481 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 233413004482 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 233413004483 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 233413004484 P-loop; other site 233413004485 Magnesium ion binding site [ion binding]; other site 233413004486 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 233413004487 Magnesium ion binding site [ion binding]; other site 233413004488 ScpA/B protein; Region: ScpA_ScpB; cl00598 233413004489 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 233413004490 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 233413004491 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 233413004492 RNA binding surface [nucleotide binding]; other site 233413004493 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 233413004494 active site 233413004495 cytidylate kinase; Provisional; Region: cmk; PRK00023 233413004496 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 233413004497 CMP-binding site; other site 233413004498 The sites determining sugar specificity; other site 233413004499 GTP-binding protein Der; Reviewed; Region: PRK03003 233413004500 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 233413004501 GTP/Mg2+ binding site [chemical binding]; other site 233413004502 Switch I region; other site 233413004503 G2 box; other site 233413004504 Switch II region; other site 233413004505 G3 box; other site 233413004506 G4 box; other site 233413004507 G5 box; other site 233413004508 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 233413004509 G1 box; other site 233413004510 GTP/Mg2+ binding site [chemical binding]; other site 233413004511 Switch I region; other site 233413004512 G2 box; other site 233413004513 G3 box; other site 233413004514 Switch II region; other site 233413004515 G4 box; other site 233413004516 G5 box; other site 233413004517 short chain dehydrogenase; Provisional; Region: PRK07060 233413004518 classical (c) SDRs; Region: SDR_c; cd05233 233413004519 NAD(P) binding site [chemical binding]; other site 233413004520 active site 233413004521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413004522 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 233413004523 Putative cyclase; Region: Cyclase; cl00814 233413004524 Cupin domain; Region: Cupin_2; cl09118 233413004525 Uncharacterized conserved protein [Function unknown]; Region: COG3246 233413004526 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 233413004527 putative switch regulator; other site 233413004528 non-specific DNA interactions [nucleotide binding]; other site 233413004529 DNA binding site [nucleotide binding] 233413004530 sequence specific DNA binding site [nucleotide binding]; other site 233413004531 putative cAMP binding site [chemical binding]; other site 233413004532 Bacterial transcriptional regulator; Region: IclR; pfam01614 233413004533 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 233413004534 putative active site [active] 233413004535 homotetrameric interface [polypeptide binding]; other site 233413004536 metal binding site [ion binding]; metal-binding site 233413004537 biotin carboxylase-like protein; Validated; Region: PRK06524 233413004538 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 233413004539 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413004540 Helix-turn-helix domains; Region: HTH; cl00088 233413004541 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 233413004542 FAD binding domain; Region: FAD_binding_4; pfam01565 233413004543 Berberine and berberine like; Region: BBE; pfam08031 233413004544 DinB superfamily; Region: DinB_2; cl00986 233413004545 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413004546 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 233413004547 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413004548 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 233413004549 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 233413004550 NAD(P) binding site [chemical binding]; other site 233413004551 catalytic residues [active] 233413004552 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 233413004553 putative catalytic residue [active] 233413004554 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 233413004555 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 233413004556 gating phenylalanine in ion channel; other site 233413004557 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 233413004558 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 233413004559 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 233413004560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413004561 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 233413004562 putative substrate translocation pore; other site 233413004563 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 233413004564 high affinity sulphate transporter 1; Region: sulP; TIGR00815 233413004565 Permease family; Region: Xan_ur_permease; cl00967 233413004566 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 233413004567 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 233413004568 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413004569 putative active site [active] 233413004570 Protein kinase domain; Region: Pkinase; pfam00069 233413004571 Catalytic domain of Protein Kinases; Region: PKc; cd00180 233413004572 active site 233413004573 ATP binding site [chemical binding]; other site 233413004574 substrate binding site [chemical binding]; other site 233413004575 activation loop (A-loop); other site 233413004576 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 233413004577 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 233413004578 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 233413004579 active site 233413004580 metal binding site [ion binding]; metal-binding site 233413004581 nudix motif; other site 233413004582 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 233413004583 Catalytic domain of Protein Kinases; Region: PKc; cd00180 233413004584 active site 233413004585 ATP binding site [chemical binding]; other site 233413004586 substrate binding site [chemical binding]; other site 233413004587 activation loop (A-loop); other site 233413004588 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 233413004589 phosphopeptide binding site; other site 233413004590 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 233413004591 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 233413004592 phosphopeptide binding site; other site 233413004593 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 233413004594 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 233413004595 Walker A/P-loop; other site 233413004596 ATP binding site [chemical binding]; other site 233413004597 Q-loop/lid; other site 233413004598 ABC transporter signature motif; other site 233413004599 Walker B; other site 233413004600 D-loop; other site 233413004601 H-loop/switch region; other site 233413004602 ABC-2 type transporter; Region: ABC2_membrane; cl11417 233413004603 acyl-CoA synthetase; Provisional; Region: PRK13388 233413004604 AMP-binding enzyme; Region: AMP-binding; cl15778 233413004605 hypothetical protein; Provisional; Region: PRK06185 233413004606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413004607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413004608 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 233413004609 PPE family; Region: PPE; pfam00823 233413004610 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413004611 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413004612 EBNA-3B; Provisional; Region: PHA03378 233413004613 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 233413004614 Phosphoesterase family; Region: Phosphoesterase; cl15450 233413004615 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 233413004616 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 233413004617 sulfite oxidase; Provisional; Region: PLN00177 233413004618 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 233413004619 Moco binding site; other site 233413004620 metal coordination site [ion binding]; other site 233413004621 dimerization interface [polypeptide binding]; other site 233413004622 Transport protein; Region: actII; TIGR00833 233413004623 Cutinase; Region: Cutinase; cl15711 233413004624 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413004625 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413004626 Domain of unknown function (DUF74); Region: DUF74; cl00426 233413004627 Domain of unknown function (DUF74); Region: DUF74; cl00426 233413004628 Domain of unknown function DUF222; Region: DUF222; pfam02720 233413004629 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413004630 active site 233413004631 Integrase core domain; Region: rve; cl01316 233413004632 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 233413004633 putative homotetramer interface [polypeptide binding]; other site 233413004634 putative homodimer interface [polypeptide binding]; other site 233413004635 putative allosteric switch controlling residues; other site 233413004636 putative metal binding site [ion binding]; other site 233413004637 putative homodimer-homodimer interface [polypeptide binding]; other site 233413004638 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 233413004639 PE family; Region: PE; pfam00934 233413004640 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 233413004641 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 233413004642 dimer interface [polypeptide binding]; other site 233413004643 active site 233413004644 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 233413004645 substrate binding site [chemical binding]; other site 233413004646 catalytic residue [active] 233413004647 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 233413004648 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 233413004649 metal binding site [ion binding]; metal-binding site 233413004650 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 233413004651 FAD binding domain; Region: FAD_binding_4; pfam01565 233413004652 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 233413004653 ANTAR domain; Region: ANTAR; cl04297 233413004654 Helix-turn-helix domains; Region: HTH; cl00088 233413004655 Transcriptional regulator [Transcription]; Region: IclR; COG1414 233413004656 Bacterial transcriptional regulator; Region: IclR; pfam01614 233413004657 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 233413004658 FAD binding domain; Region: FAD_binding_4; pfam01565 233413004659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413004660 Helix-turn-helix domains; Region: HTH; cl00088 233413004661 Cytochrome P450; Region: p450; cl12078 233413004662 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 233413004663 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 233413004664 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 233413004665 Protein of unknown function (DUF690); Region: DUF690; cl04939 233413004666 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 233413004667 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413004668 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 233413004669 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413004670 Cytochrome P450; Region: p450; cl12078 233413004671 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 233413004672 PPE family; Region: PPE; pfam00823 233413004673 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413004674 PE family; Region: PE; pfam00934 233413004675 PPE family; Region: PPE; pfam00823 233413004676 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413004677 PPE family; Region: PPE; pfam00823 233413004678 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413004679 PE family; Region: PE; pfam00934 233413004680 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413004681 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413004682 EspG family; Region: ESX-1_EspG; pfam14011 233413004683 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 233413004684 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 233413004685 catalytic residues [active] 233413004686 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 233413004687 active site 233413004688 catalytic residues [active] 233413004689 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 233413004690 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 233413004691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413004692 Walker A motif; other site 233413004693 ATP binding site [chemical binding]; other site 233413004694 Walker B motif; other site 233413004695 arginine finger; other site 233413004696 PPE family; Region: PPE; pfam00823 233413004697 Cutinase; Region: Cutinase; cl15711 233413004698 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 233413004699 PPE family; Region: PPE; pfam00823 233413004700 PPE family; Region: PPE; pfam00823 233413004701 PE family; Region: PE; pfam00934 233413004702 Protein of unknown function (DUF732); Region: DUF732; pfam05305 233413004703 PE family; Region: PE; pfam00934 233413004704 PPE family; Region: PPE; pfam00823 233413004705 PPE family; Region: PPE; pfam00823 233413004706 PPE family; Region: PPE; pfam00823 233413004707 Mb1839, PPE33b, len: 282 aa. Equivalent to 3' end of Rv1809, len: 468 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to RV1802AL022021|MTV049.23 (463 aa), FASTA scores: opt: 1238, E(): 0, (51.2% identity in 471 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE33 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t), splits PPE33 into 2 parts, PPE33a and PPE33b, with PPE33a being truncated.;PPE FAMILY PROTEIN [SECOND PART] 233413004708 Protein of unknown function (DUF732); Region: DUF732; pfam05305 233413004709 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 233413004710 MgtC family; Region: MgtC; cl12207 233413004711 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 233413004712 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 233413004713 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 233413004714 similar to hypothetical protein; Mb1847, -, len: 26 aa. Equivalent to Rv1816A, len: 26 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 26 aa overlap). Conserved hypothetical protein. 233413004715 hypothetical protein; Validated; Region: PRK07121 233413004716 PE family; Region: PE; pfam00934 233413004717 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 233413004718 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 233413004719 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 233413004720 hypothetical protein; Provisional; Region: PRK05858 233413004721 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 233413004722 PYR/PP interface [polypeptide binding]; other site 233413004723 dimer interface [polypeptide binding]; other site 233413004724 TPP binding site [chemical binding]; other site 233413004725 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 233413004726 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 233413004727 TPP-binding site; other site 233413004728 dimer interface [polypeptide binding]; other site 233413004729 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 233413004730 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 233413004731 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 233413004732 nucleotide binding region [chemical binding]; other site 233413004733 ATP-binding site [chemical binding]; other site 233413004734 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 233413004735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 233413004736 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 233413004737 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 233413004738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 233413004739 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 233413004740 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 233413004741 lipoyl attachment site [posttranslational modification]; other site 233413004742 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 233413004743 phosphopeptide binding site; other site 233413004744 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 233413004745 DNA binding residues [nucleotide binding] 233413004746 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 233413004747 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 233413004748 DNA binding residues [nucleotide binding] 233413004749 putative dimer interface [polypeptide binding]; other site 233413004750 glycine dehydrogenase; Provisional; Region: PRK05367 233413004751 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 233413004752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413004753 tetramer interface [polypeptide binding]; other site 233413004754 catalytic residue [active] 233413004755 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 233413004756 tetramer interface [polypeptide binding]; other site 233413004757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413004758 catalytic residue [active] 233413004759 haloalkane dehalogenase; Provisional; Region: PRK03204 233413004760 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413004761 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 233413004762 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 233413004763 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 233413004764 metal ion-dependent adhesion site (MIDAS); other site 233413004765 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 233413004766 active site 233413004767 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 233413004768 putative active site [active] 233413004769 Domain of unknown function DUF21; Region: DUF21; pfam01595 233413004770 FOG: CBS domain [General function prediction only]; Region: COG0517 233413004771 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 233413004772 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 233413004773 Domain of unknown function DUF21; Region: DUF21; pfam01595 233413004774 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 233413004775 Transporter associated domain; Region: CorC_HlyC; cl08393 233413004776 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 233413004777 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 233413004778 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 233413004779 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 233413004780 active site 233413004781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413004782 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 233413004783 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 233413004784 Peptidase family M48; Region: Peptidase_M48; cl12018 233413004785 Helix-turn-helix domains; Region: HTH; cl00088 233413004786 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 233413004787 CoenzymeA binding site [chemical binding]; other site 233413004788 subunit interaction site [polypeptide binding]; other site 233413004789 PHB binding site; other site 233413004790 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 233413004791 alpha-gamma subunit interface [polypeptide binding]; other site 233413004792 beta-gamma subunit interface [polypeptide binding]; other site 233413004793 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 233413004794 gamma-beta subunit interface [polypeptide binding]; other site 233413004795 alpha-beta subunit interface [polypeptide binding]; other site 233413004796 urease subunit alpha; Reviewed; Region: ureC; PRK13206 233413004797 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 233413004798 subunit interactions [polypeptide binding]; other site 233413004799 active site 233413004800 flap region; other site 233413004801 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 233413004802 UreF; Region: UreF; pfam01730 233413004803 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413004804 UreD urease accessory protein; Region: UreD; cl00530 233413004805 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 233413004806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413004807 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 233413004808 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 233413004809 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 233413004810 classical (c) SDRs; Region: SDR_c; cd05233 233413004811 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 233413004812 NAD(P) binding site [chemical binding]; other site 233413004813 active site 233413004814 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 233413004815 sulfate transport protein; Provisional; Region: cysT; CHL00187 233413004816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413004817 dimer interface [polypeptide binding]; other site 233413004818 conserved gate region; other site 233413004819 putative PBP binding loops; other site 233413004820 ABC-ATPase subunit interface; other site 233413004821 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 233413004822 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413004823 Walker A/P-loop; other site 233413004824 ATP binding site [chemical binding]; other site 233413004825 Q-loop/lid; other site 233413004826 ABC transporter signature motif; other site 233413004827 Walker B; other site 233413004828 D-loop; other site 233413004829 H-loop/switch region; other site 233413004830 TOBE domain; Region: TOBE_2; cl01440 233413004831 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 233413004832 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 233413004833 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 233413004834 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 233413004835 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 233413004836 putative NAD(P) binding site [chemical binding]; other site 233413004837 putative substrate binding site [chemical binding]; other site 233413004838 catalytic Zn binding site [ion binding]; other site 233413004839 structural Zn binding site [ion binding]; other site 233413004840 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 233413004841 MOSC domain; Region: MOSC; pfam03473 233413004842 short chain dehydrogenase; Provisional; Region: PRK07825 233413004843 classical (c) SDRs; Region: SDR_c; cd05233 233413004844 NAD(P) binding site [chemical binding]; other site 233413004845 active site 233413004846 CoA-transferase family III; Region: CoA_transf_3; pfam02515 233413004847 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 233413004848 CoA-transferase family III; Region: CoA_transf_3; pfam02515 233413004849 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 233413004850 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 233413004851 active site 233413004852 hypothetical protein; Provisional; Region: PRK05865 233413004853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413004854 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 233413004855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 233413004856 Domain of unknown function (DUF385); Region: DUF385; cl04387 233413004857 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 233413004858 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 233413004859 active site 233413004860 substrate binding site [chemical binding]; other site 233413004861 FMN binding site [chemical binding]; other site 233413004862 putative catalytic residues [active] 233413004863 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 233413004864 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 233413004865 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 233413004866 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 233413004867 heme binding site [chemical binding]; other site 233413004868 ferroxidase pore; other site 233413004869 ferroxidase diiron center [ion binding]; other site 233413004870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413004871 putative substrate translocation pore; other site 233413004872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413004873 Fungal trichothecene efflux pump (TRI12); Region: TRI12; pfam06609 233413004874 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 233413004875 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 233413004876 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 233413004877 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 233413004878 Cytochrome P450; Region: p450; cl12078 233413004879 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 233413004880 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 233413004881 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 233413004882 putative NAD(P) binding site [chemical binding]; other site 233413004883 active site 233413004884 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 233413004885 hydrophobic ligand binding site; other site 233413004886 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 233413004887 Chorismate mutase type II; Region: CM_2; cl00693 233413004888 Putative esterase; Region: Esterase; pfam00756 233413004889 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413004890 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413004891 YceI-like domain; Region: YceI; cl01001 233413004892 Nitronate monooxygenase; Region: NMO; pfam03060 233413004893 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 233413004894 FMN binding site [chemical binding]; other site 233413004895 substrate binding site [chemical binding]; other site 233413004896 putative catalytic residue [active] 233413004897 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 233413004898 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 233413004899 NAD(P) binding site [chemical binding]; other site 233413004900 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413004901 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 233413004902 putative active site [active] 233413004903 dimerization interface [polypeptide binding]; other site 233413004904 putative tRNAtyr binding site [nucleotide binding]; other site 233413004905 Domain of unknown function DUF77; Region: DUF77; cl00307 233413004906 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 233413004907 putative ADP-ribose binding site [chemical binding]; other site 233413004908 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 233413004909 cyclase homology domain; Region: CHD; cd07302 233413004910 nucleotidyl binding site; other site 233413004911 metal binding site [ion binding]; metal-binding site 233413004912 dimer interface [polypeptide binding]; other site 233413004913 competence damage-inducible protein A; Provisional; Region: PRK00549 233413004914 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 233413004915 putative MPT binding site; other site 233413004916 Competence-damaged protein; Region: CinA; cl00666 233413004917 putative sialic acid transporter; Region: 2A0112; TIGR00891 233413004918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413004919 putative substrate translocation pore; other site 233413004920 Membrane protein of unknown function; Region: DUF360; cl00850 233413004921 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 233413004922 anti sigma factor interaction site; other site 233413004923 regulatory phosphorylation site [posttranslational modification]; other site 233413004924 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 233413004925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413004926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413004927 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 233413004928 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 233413004929 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 233413004930 dimer interface [polypeptide binding]; other site 233413004931 active site 233413004932 heme binding site [chemical binding]; other site 233413004933 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 233413004934 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 233413004935 metal binding site 2 [ion binding]; metal-binding site 233413004936 putative DNA binding helix; other site 233413004937 metal binding site 1 [ion binding]; metal-binding site 233413004938 dimer interface [polypeptide binding]; other site 233413004939 structural Zn2+ binding site [ion binding]; other site 233413004940 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 233413004941 substrate binding site [chemical binding]; other site 233413004942 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 233413004943 substrate binding site [chemical binding]; other site 233413004944 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 233413004945 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 233413004946 putative NAD(P) binding site [chemical binding]; other site 233413004947 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413004948 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 233413004949 tetramer interface [polypeptide binding]; other site 233413004950 active site 233413004951 Mg2+/Mn2+ binding site [ion binding]; other site 233413004952 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 233413004953 PPE family; Region: PPE; pfam00823 233413004954 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413004955 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413004956 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413004957 Mb1952c, PPE35b, len: 334 aa. Equivalent to 3' end of Rv1918c, len: 987 aa, from Mycobacterium tuberculosis strain H37Rv, (99.1% identity in 334 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. Similar to MTCY28.16|Z95890 M. tuberculosis cosmid (1053 aa), FASTA scores: opt: 3404, E(): 0, (65.6% identity in 1058 aa overlap). Also similar to MTV004.05, MTY13E10.17, MTV014.03, MTCY3C7.23, MTCY6G11.05, MTCY48.17, MTV004.03, MTCY31.07, MTCY4C12.36, MTCY180.01, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PPE35 into 2 parts, PPE35a and PPE35b.;PPE FAMILY PROTEIN 233413004958 PPE family; Region: PPE; pfam00823 233413004959 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413004960 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413004961 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 233413004962 putative hydrophobic ligand binding site [chemical binding]; other site 233413004963 protein interface [polypeptide binding]; other site 233413004964 gate; other site 233413004965 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 233413004966 putative acyl-acceptor binding pocket; other site 233413004967 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413004968 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413004969 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 233413004970 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413004971 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 233413004972 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413004973 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413004974 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 233413004975 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 233413004976 short chain dehydrogenase; Provisional; Region: PRK05867 233413004977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413004978 NAD(P) binding site [chemical binding]; other site 233413004979 active site 233413004980 TIGR03085 family protein; Region: TIGR03085 233413004981 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 233413004982 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 233413004983 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 233413004984 conserved cys residue [active] 233413004985 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 233413004986 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 233413004987 dimer interface [polypeptide binding]; other site 233413004988 catalytic triad [active] 233413004989 peroxidatic and resolving cysteines [active] 233413004990 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413004991 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 233413004992 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 233413004993 active site 233413004994 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413004995 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 233413004996 FAD binding site [chemical binding]; other site 233413004997 substrate binding site [chemical binding]; other site 233413004998 catalytic base [active] 233413004999 enoyl-CoA hydratase; Provisional; Region: PRK08290 233413005000 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413005001 substrate binding site [chemical binding]; other site 233413005002 oxyanion hole (OAH) forming residues; other site 233413005003 trimer interface [polypeptide binding]; other site 233413005004 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 233413005005 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 233413005006 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 233413005007 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 233413005008 catalytic loop [active] 233413005009 iron binding site [ion binding]; other site 233413005010 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 233413005011 FAD binding pocket [chemical binding]; other site 233413005012 FAD binding motif [chemical binding]; other site 233413005013 phosphate binding motif [ion binding]; other site 233413005014 beta-alpha-beta structure motif; other site 233413005015 NAD binding pocket [chemical binding]; other site 233413005016 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 233413005017 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413005018 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413005019 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 233413005020 Flavin Reductases; Region: FlaRed; cl00801 233413005021 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 233413005022 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 233413005023 dimerization interface [polypeptide binding]; other site 233413005024 active site 233413005025 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 233413005026 putative NAD(P) binding site [chemical binding]; other site 233413005027 active site 233413005028 homodimer interface [polypeptide binding]; other site 233413005029 PemK-like protein; Region: PemK; cl00995 233413005030 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900 233413005031 SEC-C motif; Region: SEC-C; pfam02810 233413005032 Domain of unknown function DUF222; Region: DUF222; pfam02720 233413005033 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413005034 active site 233413005035 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 233413005036 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413005037 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 233413005038 Helix-turn-helix domains; Region: HTH; cl00088 233413005039 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 233413005040 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 233413005041 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 233413005042 putative active site [active] 233413005043 Helix-turn-helix domains; Region: HTH; cl00088 233413005044 Helix-turn-helix domains; Region: HTH; cl00088 233413005045 Domain of unknown function DUF140; Region: DUF140; cl00510 233413005046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413005047 S-adenosylmethionine binding site [chemical binding]; other site 233413005048 Amino acid permease; Region: AA_permease; cl00524 233413005049 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 233413005050 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 233413005051 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 233413005052 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 233413005053 dimer interface [polypeptide binding]; other site 233413005054 putative radical transfer pathway; other site 233413005055 diiron center [ion binding]; other site 233413005056 tyrosyl radical; other site 233413005057 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 233413005058 putative active site [active] 233413005059 PE family; Region: PE; pfam00934 233413005060 Cutinase; Region: Cutinase; cl15711 233413005061 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 233413005062 Helix-turn-helix domains; Region: HTH; cl00088 233413005063 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 233413005064 dimerization interface [polypeptide binding]; other site 233413005065 LysE type translocator; Region: LysE; cl00565 233413005066 Cellulose binding domain; Region: CBM_2; cl02709 233413005067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413005068 S-adenosylmethionine binding site [chemical binding]; other site 233413005069 RES domain; Region: RES; cl02411 233413005070 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 233413005071 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 233413005072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413005073 PemK-like protein; Region: PemK; cl00995 233413005074 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 233413005075 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 233413005076 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413005077 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 233413005078 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 233413005079 dimerization interface [polypeptide binding]; other site 233413005080 putative DNA binding site [nucleotide binding]; other site 233413005081 putative Zn2+ binding site [ion binding]; other site 233413005082 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 233413005083 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 233413005084 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 233413005085 Ligand Binding Site [chemical binding]; other site 233413005086 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 233413005087 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 233413005088 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 233413005089 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413005090 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 233413005091 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 233413005092 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 233413005093 tetramer interface [polypeptide binding]; other site 233413005094 active site 233413005095 Mg2+/Mn2+ binding site [ion binding]; other site 233413005096 Amino acid permease; Region: AA_permease; cl00524 233413005097 Amino acid permease; Region: AA_permease; cl00524 233413005098 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 233413005099 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 233413005100 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 233413005101 homotetramer interface [polypeptide binding]; other site 233413005102 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 233413005103 NAD binding site [chemical binding]; other site 233413005104 homodimer interface [polypeptide binding]; other site 233413005105 active site 233413005106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413005107 S-adenosylmethionine binding site [chemical binding]; other site 233413005108 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 233413005109 Predicted kinase [General function prediction only]; Region: COG0645 233413005110 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413005111 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 233413005112 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 233413005113 Ligand Binding Site [chemical binding]; other site 233413005114 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413005115 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 233413005116 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413005117 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 233413005118 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 233413005119 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 233413005120 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 233413005121 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 233413005122 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 233413005123 4Fe-4S binding domain; Region: Fer4; cl02805 233413005124 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413005125 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 233413005126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413005127 Walker A motif; other site 233413005128 ATP binding site [chemical binding]; other site 233413005129 Walker B motif; other site 233413005130 arginine finger; other site 233413005131 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 233413005132 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 233413005133 putative active site [active] 233413005134 Transcriptional regulators [Transcription]; Region: MarR; COG1846 233413005135 Helix-turn-helix domains; Region: HTH; cl00088 233413005136 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 233413005137 Transposase; Region: DEDD_Tnp_IS110; pfam01548 233413005138 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 233413005139 Domain of unknown function DUF222; Region: DUF222; pfam02720 233413005140 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413005141 active site 233413005142 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 233413005143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 233413005144 non-specific DNA binding site [nucleotide binding]; other site 233413005145 salt bridge; other site 233413005146 sequence-specific DNA binding site [nucleotide binding]; other site 233413005147 Domain of unknown function (DUF955); Region: DUF955; cl01076 233413005148 Protein of unknown function (DUF433); Region: DUF433; cl01030 233413005149 Predicted helicase [General function prediction only]; Region: COG4889 233413005150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 233413005151 non-specific DNA binding site [nucleotide binding]; other site 233413005152 salt bridge; other site 233413005153 sequence-specific DNA binding site [nucleotide binding]; other site 233413005154 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 233413005155 Predicted helicase [General function prediction only]; Region: COG4889 233413005156 Restriction endonuclease; Region: Mrr_cat; cl00747 233413005157 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413005158 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 233413005159 ATP binding site [chemical binding]; other site 233413005160 putative Mg++ binding site [ion binding]; other site 233413005161 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413005162 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 233413005163 Cation efflux family; Region: Cation_efflux; cl00316 233413005164 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 233413005165 Ligand Binding Site [chemical binding]; other site 233413005166 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 233413005167 Ligand Binding Site [chemical binding]; other site 233413005168 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 233413005169 GAF domain; Region: GAF; cl00853 233413005170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 233413005171 Histidine kinase; Region: HisKA_3; pfam07730 233413005172 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 233413005173 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 233413005174 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 233413005175 putative substrate binding site [chemical binding]; other site 233413005176 putative ATP binding site [chemical binding]; other site 233413005177 Erythromycin esterase; Region: Erythro_esteras; pfam05139 233413005178 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 233413005179 Erythromycin esterase; Region: Erythro_esteras; pfam05139 233413005180 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 233413005181 putative dimer interface [polypeptide binding]; other site 233413005182 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 233413005183 hypothetical protein; Provisional; Region: PRK07877 233413005184 dimer interface [polypeptide binding]; other site 233413005185 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 233413005186 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 233413005187 putative DNA binding site [nucleotide binding]; other site 233413005188 dimerization interface [polypeptide binding]; other site 233413005189 putative Zn2+ binding site [ion binding]; other site 233413005190 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 233413005191 putative hydrophobic ligand binding site [chemical binding]; other site 233413005192 CLM binding site; other site 233413005193 L1 loop; other site 233413005194 DNA binding site [nucleotide binding] 233413005195 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 233413005196 DinB superfamily; Region: DinB_2; cl00986 233413005197 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 233413005198 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 233413005199 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 233413005200 nucleophile elbow; other site 233413005201 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 233413005202 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 233413005203 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 233413005204 Walker A/P-loop; other site 233413005205 ATP binding site [chemical binding]; other site 233413005206 Q-loop/lid; other site 233413005207 ABC transporter signature motif; other site 233413005208 Walker B; other site 233413005209 D-loop; other site 233413005210 H-loop/switch region; other site 233413005211 TOBE domain; Region: TOBE_2; cl01440 233413005212 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 233413005213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413005214 dimer interface [polypeptide binding]; other site 233413005215 conserved gate region; other site 233413005216 putative PBP binding loops; other site 233413005217 ABC-ATPase subunit interface; other site 233413005218 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 233413005219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413005220 dimer interface [polypeptide binding]; other site 233413005221 conserved gate region; other site 233413005222 putative PBP binding loops; other site 233413005223 ABC-ATPase subunit interface; other site 233413005224 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 233413005225 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 233413005226 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 233413005227 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 233413005228 Isochorismatase family; Region: Isochorismatase; pfam00857 233413005229 catalytic triad [active] 233413005230 metal binding site [ion binding]; metal-binding site 233413005231 conserved cis-peptide bond; other site 233413005232 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 233413005233 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 233413005234 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413005235 substrate binding pocket [chemical binding]; other site 233413005236 catalytic triad [active] 233413005237 hypothetical protein; Provisional; Region: PRK05865 233413005238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413005239 NAD(P) binding site [chemical binding]; other site 233413005240 active site 233413005241 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 233413005242 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 233413005243 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413005244 active site 233413005245 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413005246 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 233413005247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413005248 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 233413005249 Enoylreductase; Region: PKS_ER; smart00829 233413005250 NAD(P) binding site [chemical binding]; other site 233413005251 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 233413005252 putative NADP binding site [chemical binding]; other site 233413005253 active site 233413005254 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413005255 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 233413005256 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413005257 active site 233413005258 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413005259 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 233413005260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413005261 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 233413005262 Enoylreductase; Region: PKS_ER; smart00829 233413005263 NAD(P) binding site [chemical binding]; other site 233413005264 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 233413005265 putative NADP binding site [chemical binding]; other site 233413005266 active site 233413005267 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413005268 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 233413005269 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 233413005270 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 233413005271 putative active site [active] 233413005272 catalytic triad [active] 233413005273 putative dimer interface [polypeptide binding]; other site 233413005274 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 233413005275 Ligand binding site; other site 233413005276 Putative Catalytic site; other site 233413005277 DXD motif; other site 233413005278 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 233413005279 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 233413005280 active site 233413005281 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 233413005282 Dienelactone hydrolase family; Region: DLH; pfam01738 233413005283 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413005284 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 233413005285 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 233413005286 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 233413005287 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 233413005288 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 233413005289 intersubunit interface [polypeptide binding]; other site 233413005290 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 233413005291 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 233413005292 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 233413005293 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 233413005294 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 233413005295 precorrin-3B synthase; Region: CobG; TIGR02435 233413005296 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 233413005297 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 233413005298 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 233413005299 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 233413005300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413005301 S-adenosylmethionine binding site [chemical binding]; other site 233413005302 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 233413005303 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413005304 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 233413005305 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 233413005306 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 233413005307 DNA binding residues [nucleotide binding] 233413005308 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 233413005309 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 233413005310 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 233413005311 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 233413005312 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 233413005313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413005314 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 233413005315 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 233413005316 active site 233413005317 catalytic site [active] 233413005318 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 233413005319 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 233413005320 Mb2111, -, len: 110 aa. Similar to 3' end of Rv2084, len: 378 aa, from Mycobacterium tuberculosis strain H37Rv, (97.0% identity in 100 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis stain H37Rv, Rv2084 exists as a single gene. In Mycobacterium bovis, a frameshift due to an 11 bp insertion (*-ggcgtacacac), splits Rv2084 into 2 parts, Mb2110 and Mb2111.;HYPOTHETICAL PROTEIN 233413005321 putative transposase OrfB; Reviewed; Region: PHA02517 233413005322 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 233413005323 Catalytic domain of Protein Kinases; Region: PKc; cd00180 233413005324 active site 233413005325 ATP binding site [chemical binding]; other site 233413005326 substrate binding site [chemical binding]; other site 233413005327 activation loop (A-loop); other site 233413005328 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 233413005329 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 233413005330 active site 233413005331 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 233413005332 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 233413005333 active site 233413005334 metal binding site 1 [ion binding]; metal-binding site 233413005335 putative 5' ssDNA interaction site; other site 233413005336 metal binding site 3; metal-binding site 233413005337 metal binding site 2 [ion binding]; metal-binding site 233413005338 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 233413005339 putative DNA binding site [nucleotide binding]; other site 233413005340 putative metal binding site [ion binding]; other site 233413005341 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 233413005342 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 233413005343 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 233413005344 ATP binding site [chemical binding]; other site 233413005345 putative Mg++ binding site [ion binding]; other site 233413005346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 233413005347 nucleotide binding region [chemical binding]; other site 233413005348 ATP-binding site [chemical binding]; other site 233413005349 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 233413005350 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 233413005351 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 233413005352 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 233413005353 Predicted transcriptional regulator [Transcription]; Region: COG2378 233413005354 Predicted transcriptional regulator [Transcription]; Region: COG2378 233413005355 Pup-ligase protein; Region: Pup_ligase; cl15463 233413005356 PE family; Region: PE; pfam00934 233413005357 Domain of unknown function DUF222; Region: DUF222; pfam02720 233413005358 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413005359 active site 233413005360 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 233413005361 SNF2 Helicase protein; Region: DUF3670; pfam12419 233413005362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 233413005363 ATP binding site [chemical binding]; other site 233413005364 putative Mg++ binding site [ion binding]; other site 233413005365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 233413005366 nucleotide binding region [chemical binding]; other site 233413005367 ATP-binding site [chemical binding]; other site 233413005368 SWIM zinc finger; Region: SWIM; cl15408 233413005369 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413005370 PE family; Region: PE; pfam00934 233413005371 PPE family; Region: PPE; pfam00823 233413005372 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 233413005373 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 233413005374 active site 233413005375 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]; Region: PRE1; COG0638 233413005376 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 233413005377 active site 233413005378 Pup-like protein; Region: Pup; cl05289 233413005379 Pup-ligase protein; Region: Pup_ligase; cl15463 233413005380 proteasome ATPase; Region: pup_AAA; TIGR03689 233413005381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413005382 Walker A motif; other site 233413005383 ATP binding site [chemical binding]; other site 233413005384 Walker B motif; other site 233413005385 arginine finger; other site 233413005386 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 233413005387 Protein of unknown function (DUF503); Region: DUF503; cl00669 233413005388 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 233413005389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413005390 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 233413005391 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 233413005392 Predicted membrane protein [Function unknown]; Region: COG3918 233413005393 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 233413005394 ATP phosphoribosyltransferase; Region: HisG; cl15266 233413005395 HisG, C-terminal domain; Region: HisG_C; cl06867 233413005396 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 233413005397 PPE family; Region: PPE; pfam00823 233413005398 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 233413005399 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 233413005400 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 233413005401 substrate binding pocket [chemical binding]; other site 233413005402 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 233413005403 B12 binding site [chemical binding]; other site 233413005404 cobalt ligand [ion binding]; other site 233413005405 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 233413005406 PAC2 family; Region: PAC2; cl00847 233413005407 Amino acid permease; Region: AA_permease; cl00524 233413005408 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 233413005409 short chain dehydrogenase; Provisional; Region: PRK05872 233413005410 classical (c) SDRs; Region: SDR_c; cd05233 233413005411 NAD(P) binding site [chemical binding]; other site 233413005412 active site 233413005413 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 233413005414 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 233413005415 active site 233413005416 HIGH motif; other site 233413005417 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 233413005418 active site 233413005419 KMSKS motif; other site 233413005420 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 233413005421 putative tRNA binding surface [nucleotide binding]; other site 233413005422 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 233413005423 active site 233413005424 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 233413005425 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 233413005426 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 233413005427 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 233413005428 catalytic core [active] 233413005429 Bacitracin resistance protein BacA; Region: BacA; cl00858 233413005430 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 233413005431 quinone interaction residues [chemical binding]; other site 233413005432 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 233413005433 active site 233413005434 catalytic residues [active] 233413005435 FMN binding site [chemical binding]; other site 233413005436 substrate binding site [chemical binding]; other site 233413005437 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 233413005438 substrate binding site [chemical binding]; other site 233413005439 hypothetical protein; Provisional; Region: PRK07906 233413005440 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 233413005441 putative metal binding site [ion binding]; other site 233413005442 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 233413005443 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 233413005444 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 233413005445 DivIVA domain; Region: DivI1A_domain; TIGR03544 233413005446 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 233413005447 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 233413005448 YGGT family; Region: YGGT; cl00508 233413005449 Protein of unknown function (DUF552); Region: DUF552; cl00775 233413005450 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 233413005451 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 233413005452 catalytic residue [active] 233413005453 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 233413005454 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 233413005455 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 233413005456 nucleotide binding site [chemical binding]; other site 233413005457 SulA interaction site; other site 233413005458 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 233413005459 Cell division protein FtsQ; Region: FtsQ; pfam03799 233413005460 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 233413005461 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 233413005462 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 233413005463 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 233413005464 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 233413005465 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 233413005466 active site 233413005467 homodimer interface [polypeptide binding]; other site 233413005468 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 233413005469 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 233413005470 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 233413005471 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 233413005472 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 233413005473 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 233413005474 Mg++ binding site [ion binding]; other site 233413005475 putative catalytic motif [active] 233413005476 putative substrate binding site [chemical binding]; other site 233413005477 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 233413005478 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 233413005479 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 233413005480 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 233413005481 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 233413005482 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 233413005483 Helix-turn-helix domains; Region: HTH; cl00088 233413005484 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 233413005485 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 233413005486 PE family; Region: PE; pfam00934 233413005487 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 233413005488 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 233413005489 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413005490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413005491 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 233413005492 cell division protein MraZ; Reviewed; Region: PRK00326 233413005493 MraZ protein; Region: MraZ; pfam02381 233413005494 MraZ protein; Region: MraZ; pfam02381 233413005495 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 233413005496 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 233413005497 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 233413005498 substrate binding pocket [chemical binding]; other site 233413005499 chain length determination region; other site 233413005500 substrate-Mg2+ binding site; other site 233413005501 catalytic residues [active] 233413005502 aspartate-rich region 1; other site 233413005503 active site lid residues [active] 233413005504 aspartate-rich region 2; other site 233413005505 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 233413005506 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 233413005507 Catalytic domain of Protein Kinases; Region: PKc; cd00180 233413005508 active site 233413005509 ATP binding site [chemical binding]; other site 233413005510 substrate binding site [chemical binding]; other site 233413005511 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 233413005512 substrate binding site [chemical binding]; other site 233413005513 activation loop (A-loop); other site 233413005514 activation loop (A-loop); other site 233413005515 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 233413005516 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 233413005517 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 233413005518 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 233413005519 putative acyl-acceptor binding pocket; other site 233413005520 arsenite-activated ATPase ArsA; Region: arsA; TIGR00345 233413005521 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 233413005522 DTAP/Switch II; other site 233413005523 Switch I; other site 233413005524 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 233413005525 putative hydrophobic ligand binding site [chemical binding]; other site 233413005526 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 233413005527 AMP-binding domain protein; Validated; Region: PRK08315 233413005528 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413005529 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 233413005530 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 233413005531 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 233413005532 NlpC/P60 family; Region: NLPC_P60; cl11438 233413005533 hypothetical protein; Validated; Region: PRK07883 233413005534 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 233413005535 active site 233413005536 substrate binding site [chemical binding]; other site 233413005537 catalytic site [active] 233413005538 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 233413005539 GIY-YIG motif/motif A; other site 233413005540 active site 233413005541 catalytic site [active] 233413005542 putative DNA binding site [nucleotide binding]; other site 233413005543 metal binding site [ion binding]; metal-binding site 233413005544 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 233413005545 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 233413005546 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 233413005547 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 233413005548 Subunit I/III interface [polypeptide binding]; other site 233413005549 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 233413005550 Cytochrome c; Region: Cytochrom_C; cl11414 233413005551 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 233413005552 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 233413005553 iron-sulfur cluster [ion binding]; other site 233413005554 [2Fe-2S] cluster binding site [ion binding]; other site 233413005555 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 233413005556 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 233413005557 heme bH binding site [chemical binding]; other site 233413005558 intrachain domain interface; other site 233413005559 heme bL binding site [chemical binding]; other site 233413005560 interchain domain interface [polypeptide binding]; other site 233413005561 Qo binding site; other site 233413005562 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 233413005563 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 233413005564 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 233413005565 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 233413005566 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 233413005567 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 233413005568 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 233413005569 dimer interface [polypeptide binding]; other site 233413005570 active site 233413005571 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 233413005572 Ligand Binding Site [chemical binding]; other site 233413005573 Molecular Tunnel; other site 233413005574 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 233413005575 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 233413005576 substrate binding site [chemical binding]; other site 233413005577 ATP binding site [chemical binding]; other site 233413005578 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 233413005579 Glycerate kinase family; Region: Gly_kinase; cl00841 233413005580 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 233413005581 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 233413005582 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 233413005583 putative dimer interface [polypeptide binding]; other site 233413005584 active site pocket [active] 233413005585 putative cataytic base [active] 233413005586 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 233413005587 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 233413005588 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 233413005589 homodimer interface [polypeptide binding]; other site 233413005590 substrate-cofactor binding pocket; other site 233413005591 catalytic residue [active] 233413005592 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 233413005593 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 233413005594 cyclase homology domain; Region: CHD; cd07302 233413005595 nucleotidyl binding site; other site 233413005596 metal binding site [ion binding]; metal-binding site 233413005597 dimer interface [polypeptide binding]; other site 233413005598 multifunctional aminopeptidase A; Provisional; Region: PRK00913 233413005599 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 233413005600 interface (dimer of trimers) [polypeptide binding]; other site 233413005601 Substrate-binding/catalytic site; other site 233413005602 Zn-binding sites [ion binding]; other site 233413005603 short chain dehydrogenase; Validated; Region: PRK05855 233413005604 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413005605 classical (c) SDRs; Region: SDR_c; cd05233 233413005606 NAD(P) binding site [chemical binding]; other site 233413005607 active site 233413005608 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 233413005609 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 233413005610 E3 interaction surface; other site 233413005611 lipoyl attachment site [posttranslational modification]; other site 233413005612 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 233413005613 E3 interaction surface; other site 233413005614 lipoyl attachment site [posttranslational modification]; other site 233413005615 e3 binding domain; Region: E3_binding; pfam02817 233413005616 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 233413005617 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 233413005618 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 233413005619 putative NAD(P) binding site [chemical binding]; other site 233413005620 putative active site [active] 233413005621 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 233413005622 lipoyl synthase; Provisional; Region: PRK05481 233413005623 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413005624 FeS/SAM binding site; other site 233413005625 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 233413005626 RDD family; Region: RDD; cl00746 233413005627 glutamine synthetase, type I; Region: GlnA; TIGR00653 233413005628 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 233413005629 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 233413005630 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 233413005631 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 233413005632 metal binding triad; other site 233413005633 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 233413005634 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 233413005635 metal binding triad; other site 233413005636 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 233413005637 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 233413005638 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 233413005639 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 233413005640 stage V sporulation protein AD; Validated; Region: PRK08304 233413005641 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 233413005642 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413005643 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 233413005644 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413005645 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 233413005646 oligomerization interface [polypeptide binding]; other site 233413005647 active site 233413005648 metal binding site [ion binding]; metal-binding site 233413005649 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 233413005650 putative active site; other site 233413005651 putative metal binding residues [ion binding]; other site 233413005652 signature motif; other site 233413005653 putative triphosphate binding site [ion binding]; other site 233413005654 CHAD domain; Region: CHAD; cl10506 233413005655 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 233413005656 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 233413005657 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 233413005658 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 233413005659 RNA/DNA hybrid binding site [nucleotide binding]; other site 233413005660 active site 233413005661 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 233413005662 catalytic core [active] 233413005663 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 233413005664 Putative zinc ribbon domain; Region: DUF164; pfam02591 233413005665 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 233413005666 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 233413005667 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 233413005668 hypothetical protein; Provisional; Region: PRK07908 233413005669 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 233413005670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413005671 homodimer interface [polypeptide binding]; other site 233413005672 catalytic residue [active] 233413005673 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 233413005674 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 233413005675 active site 233413005676 motif I; other site 233413005677 motif II; other site 233413005678 Low molecular weight phosphatase family; Region: LMWPc; cd00115 233413005679 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 233413005680 active site 233413005681 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 233413005682 CobD/Cbib protein; Region: CobD_Cbib; cl00561 233413005683 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 233413005684 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 233413005685 dimer interface [polypeptide binding]; other site 233413005686 catalytic triad [active] 233413005687 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 233413005688 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 233413005689 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 233413005690 dimer interface [polypeptide binding]; other site 233413005691 TPP-binding site [chemical binding]; other site 233413005692 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 233413005693 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413005694 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 233413005695 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413005696 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 233413005697 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 233413005698 dimer interface [polypeptide binding]; other site 233413005699 active site 233413005700 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 233413005701 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 233413005702 dimer interface [polypeptide binding]; other site 233413005703 active site 233413005704 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 233413005705 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 233413005706 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 233413005707 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 233413005708 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 233413005709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413005710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413005711 Helix-turn-helix domains; Region: HTH; cl00088 233413005712 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 233413005713 FAD binding domain; Region: FAD_binding_4; pfam01565 233413005714 diacylglycerol kinase; Reviewed; Region: PRK11914 233413005715 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 233413005716 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 233413005717 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413005718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413005719 S-adenosylmethionine binding site [chemical binding]; other site 233413005720 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 233413005721 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 233413005722 NAD binding site [chemical binding]; other site 233413005723 catalytic Zn binding site [ion binding]; other site 233413005724 substrate binding site [chemical binding]; other site 233413005725 structural Zn binding site [ion binding]; other site 233413005726 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413005727 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 233413005728 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 233413005729 putative active site [active] 233413005730 catalytic triad [active] 233413005731 putative dimer interface [polypeptide binding]; other site 233413005732 short chain dehydrogenase; Provisional; Region: PRK06197 233413005733 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 233413005734 putative NAD(P) binding site [chemical binding]; other site 233413005735 active site 233413005736 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 233413005737 Major Facilitator Superfamily; Region: MFS_1; pfam07690 233413005738 Cytochrome P450; Region: p450; cl12078 233413005739 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 233413005740 Cytochrome P450; Region: p450; cl12078 233413005741 Septum formation; Region: Septum_form; pfam13845 233413005742 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 233413005743 Domain of unknown function DUF; Region: DUF202; cl09954 233413005744 Domain of unknown function DUF; Region: DUF202; cl09954 233413005745 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 233413005746 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 233413005747 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 233413005748 putative active site [active] 233413005749 catalytic site [active] 233413005750 putative metal binding site [ion binding]; other site 233413005751 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 233413005752 FAD binding domain; Region: FAD_binding_4; pfam01565 233413005753 Phosphate transporter family; Region: PHO4; cl00396 233413005754 Phosphate transporter family; Region: PHO4; cl00396 233413005755 Transcriptional regulator [Transcription]; Region: LysR; COG0583 233413005756 Helix-turn-helix domains; Region: HTH; cl00088 233413005757 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 233413005758 dimerization interface [polypeptide binding]; other site 233413005759 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413005760 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 233413005761 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413005762 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413005763 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413005764 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 233413005765 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 233413005766 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 233413005767 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 233413005768 active site residue [active] 233413005769 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 233413005770 active site residue [active] 233413005771 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 233413005772 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 233413005773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 233413005774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413005775 homodimer interface [polypeptide binding]; other site 233413005776 catalytic residue [active] 233413005777 Uncharacterised protein family (UPF0167); Region: UPF0167; cl01252 233413005778 haloalkane dehalogenase; Provisional; Region: PRK00870 233413005779 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 233413005780 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 233413005781 active site 233413005782 catalytic tetrad [active] 233413005783 heat shock protein 90; Provisional; Region: PRK05218 233413005784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 233413005785 ATP binding site [chemical binding]; other site 233413005786 Mg2+ binding site [ion binding]; other site 233413005787 G-X-G motif; other site 233413005788 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413005789 Cutinase; Region: Cutinase; pfam01083 233413005790 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 233413005791 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 233413005792 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 233413005793 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 233413005794 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 233413005795 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 233413005796 Protein of unknown function (DUF433); Region: DUF433; cl01030 233413005797 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 233413005798 DNA binding site [nucleotide binding] 233413005799 active site 233413005800 Int/Topo IB signature motif; other site 233413005801 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 233413005802 DNA binding residues [nucleotide binding] 233413005803 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 233413005804 Uncharacterized conserved protein [Function unknown]; Region: COG2128 233413005805 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 233413005806 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 233413005807 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 233413005808 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 233413005809 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 233413005810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413005811 putative PBP binding loops; other site 233413005812 ABC-ATPase subunit interface; other site 233413005813 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 233413005814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413005815 dimer interface [polypeptide binding]; other site 233413005816 conserved gate region; other site 233413005817 putative PBP binding loops; other site 233413005818 ABC-ATPase subunit interface; other site 233413005819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 233413005820 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 233413005821 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 233413005822 amino acid transporter; Region: 2A0306; TIGR00909 233413005823 Spore germination protein; Region: Spore_permease; cl15802 233413005824 Spore germination protein; Region: Spore_permease; cl15802 233413005825 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 233413005826 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413005827 catalytic residue [active] 233413005828 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 233413005829 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413005830 Amidinotransferase; Region: Amidinotransf; cl12043 233413005831 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 233413005832 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 233413005833 Helix-turn-helix domains; Region: HTH; cl00088 233413005834 Cobalt transport protein; Region: CbiQ; cl00463 233413005835 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 233413005836 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 233413005837 Walker A/P-loop; other site 233413005838 ATP binding site [chemical binding]; other site 233413005839 Q-loop/lid; other site 233413005840 ABC transporter signature motif; other site 233413005841 Walker B; other site 233413005842 D-loop; other site 233413005843 H-loop/switch region; other site 233413005844 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 233413005845 Walker A/P-loop; other site 233413005846 ATP binding site [chemical binding]; other site 233413005847 Q-loop/lid; other site 233413005848 ABC transporter signature motif; other site 233413005849 Walker B; other site 233413005850 D-loop; other site 233413005851 H-loop/switch region; other site 233413005852 Helix-turn-helix domains; Region: HTH; cl00088 233413005853 PE family; Region: PE; pfam00934 233413005854 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 233413005855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413005856 putative substrate translocation pore; other site 233413005857 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 233413005858 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 233413005859 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 233413005860 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 233413005861 malate dehydrogenase; Provisional; Region: PRK13529 233413005862 Malic enzyme, N-terminal domain; Region: malic; pfam00390 233413005863 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 233413005864 NAD(P) binding site [chemical binding]; other site 233413005865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413005866 Major Facilitator Superfamily; Region: MFS_1; pfam07690 233413005867 putative substrate translocation pore; other site 233413005868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413005869 putative substrate translocation pore; other site 233413005870 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 233413005871 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 233413005872 dimer interface [polypeptide binding]; other site 233413005873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413005874 catalytic residue [active] 233413005875 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 233413005876 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 233413005877 trimer interface [polypeptide binding]; other site 233413005878 active site 233413005879 substrate binding site [chemical binding]; other site 233413005880 CoA binding site [chemical binding]; other site 233413005881 hypothetical protein; Provisional; Region: PRK14851 233413005882 hypothetical protein; Validated; Region: PRK08223 233413005883 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 233413005884 ATP binding site [chemical binding]; other site 233413005885 substrate interface [chemical binding]; other site 233413005886 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 233413005887 Transport protein; Region: actII; TIGR00833 233413005888 PE family; Region: PE; pfam00934 233413005889 DNA primase; Validated; Region: dnaG; PRK05667 233413005890 CHC2 zinc finger; Region: zf-CHC2; cl15369 233413005891 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 233413005892 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 233413005893 active site 233413005894 metal binding site [ion binding]; metal-binding site 233413005895 interdomain interaction site; other site 233413005896 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 233413005897 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 233413005898 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 233413005899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 233413005900 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 233413005901 Repair protein; Region: Repair_PSII; cl01535 233413005902 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413005903 PPE family; Region: PPE; pfam00823 233413005904 PPE family; Region: PPE; pfam00823 233413005905 PPE family; Region: PPE; pfam00823 233413005906 PPE family; Region: PPE; pfam00823 233413005907 glycyl-tRNA synthetase; Provisional; Region: PRK04173 233413005908 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 233413005909 active site 233413005910 motif 2; other site 233413005911 motif 3; other site 233413005912 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 233413005913 anticodon binding site; other site 233413005914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 233413005915 dimerization interface [polypeptide binding]; other site 233413005916 putative DNA binding site [nucleotide binding]; other site 233413005917 putative Zn2+ binding site [ion binding]; other site 233413005918 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 233413005919 metal binding site 2 [ion binding]; metal-binding site 233413005920 putative DNA binding helix; other site 233413005921 metal binding site 1 [ion binding]; metal-binding site 233413005922 dimer interface [polypeptide binding]; other site 233413005923 structural Zn2+ binding site [ion binding]; other site 233413005924 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 233413005925 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 233413005926 catalytic residue [active] 233413005927 putative FPP diphosphate binding site; other site 233413005928 putative FPP binding hydrophobic cleft; other site 233413005929 dimer interface [polypeptide binding]; other site 233413005930 putative IPP diphosphate binding site; other site 233413005931 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 233413005932 Recombination protein O N terminal; Region: RecO_N; cl15812 233413005933 Recombination protein O C terminal; Region: RecO_C; pfam02565 233413005934 amidase; Provisional; Region: PRK06061 233413005935 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 233413005936 GTPase Era; Reviewed; Region: era; PRK00089 233413005937 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 233413005938 G1 box; other site 233413005939 GTP/Mg2+ binding site [chemical binding]; other site 233413005940 Switch I region; other site 233413005941 G2 box; other site 233413005942 Switch II region; other site 233413005943 G3 box; other site 233413005944 G4 box; other site 233413005945 G5 box; other site 233413005946 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 233413005947 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 233413005948 Domain of unknown function DUF21; Region: DUF21; pfam01595 233413005949 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 233413005950 Transporter associated domain; Region: CorC_HlyC; cl08393 233413005951 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 233413005952 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 233413005953 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413005954 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 233413005955 PE family; Region: PE; pfam00934 233413005956 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 233413005957 RNA methyltransferase, RsmE family; Region: TIGR00046 233413005958 chaperone protein DnaJ; Provisional; Region: PRK14278 233413005959 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 233413005960 HSP70 interaction site [polypeptide binding]; other site 233413005961 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 233413005962 Zn binding sites [ion binding]; other site 233413005963 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 233413005964 dimer interface [polypeptide binding]; other site 233413005965 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 233413005966 Helix-turn-helix domains; Region: HTH; cl00088 233413005967 HrcA protein C terminal domain; Region: HrcA; pfam01628 233413005968 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 233413005969 MbtH-like protein; Region: MbtH; cl01279 233413005970 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 233413005971 peptide synthase; Provisional; Region: PRK12316 233413005972 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413005973 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 233413005974 peptide synthase; Provisional; Region: PRK12467 233413005975 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413005976 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413005977 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 233413005978 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413005979 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 233413005980 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413005981 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 233413005982 NADP binding site [chemical binding]; other site 233413005983 active site 233413005984 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413005985 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413005986 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 233413005987 active site 233413005988 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413005989 Condensation domain; Region: Condensation; pfam00668 233413005990 Nonribosomal peptide synthase; Region: NRPS; pfam08415 233413005991 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 233413005992 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413005993 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413005994 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 233413005995 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 233413005996 AMP-binding enzyme; Region: AMP-binding; cl15778 233413005997 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 233413005998 salicylate synthase MbtI; Reviewed; Region: PRK07912 233413005999 chorismate binding enzyme; Region: Chorismate_bind; cl10555 233413006000 Domain of unknown function (DUF897); Region: DUF897; cl01312 233413006001 coproporphyrinogen III oxidase; Validated; Region: PRK05628 233413006002 HemN C-terminal region; Region: HemN_C; pfam06969 233413006003 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 233413006004 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 233413006005 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 233413006006 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 233413006007 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 233413006008 Active Sites [active] 233413006009 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 233413006010 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 233413006011 putative active site [active] 233413006012 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 233413006013 putative active site [active] 233413006014 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 233413006015 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 233413006016 OPT oligopeptide transporter protein; Region: OPT; cl14607 233413006017 OPT oligopeptide transporter protein; Region: OPT; cl14607 233413006018 Protein of unknown function (DUF418); Region: DUF418; cl12135 233413006019 PE family; Region: PE; pfam00934 233413006020 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 233413006021 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 233413006022 Walker A/P-loop; other site 233413006023 ATP binding site [chemical binding]; other site 233413006024 Q-loop/lid; other site 233413006025 ABC transporter signature motif; other site 233413006026 Walker B; other site 233413006027 D-loop; other site 233413006028 H-loop/switch region; other site 233413006029 TOBE-like domain; Region: TOBE_3; pfam12857 233413006030 sulfate transport protein; Provisional; Region: cysT; CHL00187 233413006031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413006032 dimer interface [polypeptide binding]; other site 233413006033 conserved gate region; other site 233413006034 putative PBP binding loops; other site 233413006035 ABC-ATPase subunit interface; other site 233413006036 sulfate transport protein; Provisional; Region: cysT; CHL00187 233413006037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413006038 dimer interface [polypeptide binding]; other site 233413006039 conserved gate region; other site 233413006040 putative PBP binding loops; other site 233413006041 ABC-ATPase subunit interface; other site 233413006042 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 233413006043 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 233413006044 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 233413006045 PknH-like extracellular domain; Region: PknH_C; pfam14032 233413006046 GTP-binding protein LepA; Provisional; Region: PRK05433 233413006047 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 233413006048 G1 box; other site 233413006049 putative GEF interaction site [polypeptide binding]; other site 233413006050 GTP/Mg2+ binding site [chemical binding]; other site 233413006051 Switch I region; other site 233413006052 G2 box; other site 233413006053 G3 box; other site 233413006054 Switch II region; other site 233413006055 G4 box; other site 233413006056 G5 box; other site 233413006057 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 233413006058 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 233413006059 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 233413006060 PemK-like protein; Region: PemK; cl00995 233413006061 FOG: CBS domain [General function prediction only]; Region: COG0517 233413006062 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 233413006063 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413006064 PE family; Region: PE; pfam00934 233413006065 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 233413006066 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 233413006067 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 233413006068 Uncharacterized conserved protein [Function unknown]; Region: COG2308 233413006069 Domain of unknown function (DUF404); Region: DUF404; pfam04169 233413006070 Domain of unknown function (DUF407); Region: DUF407; pfam04174 233413006071 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 233413006072 hypothetical protein; Reviewed; Region: PRK07914 233413006073 Competence protein; Region: Competence; cl00471 233413006074 Competence protein; Region: Competence; cl00471 233413006075 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 233413006076 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 233413006077 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 233413006078 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 233413006079 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 233413006080 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 233413006081 active site 233413006082 catalytic triad [active] 233413006083 oxyanion hole [active] 233413006084 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 233413006085 catalytic core [active] 233413006086 Oligomerisation domain; Region: Oligomerisation; cl00519 233413006087 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 233413006088 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 233413006089 active site 233413006090 (T/H)XGH motif; other site 233413006091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413006092 S-adenosylmethionine binding site [chemical binding]; other site 233413006093 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 233413006094 Transposase; Region: DEDD_Tnp_IS110; pfam01548 233413006095 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 233413006096 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 233413006097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413006098 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 233413006099 Walker A motif; other site 233413006100 ATP binding site [chemical binding]; other site 233413006101 Walker B motif; other site 233413006102 arginine finger; other site 233413006103 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 233413006104 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 233413006105 putative catalytic cysteine [active] 233413006106 Mb2452c, -, len: 101 aa. Equivalent to the second part of oxyR' pseudogene (see citation below). 233413006107 Mb2453c, -, len: 66 aa. Equivalent to the first part of oxyR' pseudogene (see citation below). 233413006108 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 233413006109 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 233413006110 dimer interface [polypeptide binding]; other site 233413006111 decamer (pentamer of dimers) interface [polypeptide binding]; other site 233413006112 catalytic triad [active] 233413006113 peroxidatic and resolving cysteines [active] 233413006114 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 233413006115 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 233413006116 PPE family; Region: PPE; pfam00823 233413006117 PE family; Region: PE; pfam00934 233413006118 Mechanosensitive ion channel; Region: MS_channel; pfam00924 233413006119 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 233413006120 ligand binding site [chemical binding]; other site 233413006121 flexible hinge region; other site 233413006122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 233413006123 dimerization interface [polypeptide binding]; other site 233413006124 Heme NO binding associated; Region: HNOBA; pfam07701 233413006125 cyclase homology domain; Region: CHD; cd07302 233413006126 nucleotidyl binding site; other site 233413006127 metal binding site [ion binding]; metal-binding site 233413006128 dimer interface [polypeptide binding]; other site 233413006129 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 233413006130 substrate binding site [chemical binding]; other site 233413006131 ATP binding site [chemical binding]; other site 233413006132 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 233413006133 NAD synthetase; Reviewed; Region: nadE; PRK02628 233413006134 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 233413006135 multimer interface [polypeptide binding]; other site 233413006136 active site 233413006137 catalytic triad [active] 233413006138 protein interface 1 [polypeptide binding]; other site 233413006139 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 233413006140 homodimer interface [polypeptide binding]; other site 233413006141 NAD binding pocket [chemical binding]; other site 233413006142 ATP binding pocket [chemical binding]; other site 233413006143 Mg binding site [ion binding]; other site 233413006144 active-site loop [active] 233413006145 gamma-glutamyl kinase; Provisional; Region: PRK05429 233413006146 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 233413006147 nucleotide binding site [chemical binding]; other site 233413006148 homotetrameric interface [polypeptide binding]; other site 233413006149 putative phosphate binding site [ion binding]; other site 233413006150 putative allosteric binding site; other site 233413006151 PUA domain; Region: PUA; cl00607 233413006152 GTPase CgtA; Reviewed; Region: obgE; PRK12296 233413006153 GTP1/OBG; Region: GTP1_OBG; pfam01018 233413006154 Obg GTPase; Region: Obg; cd01898 233413006155 G1 box; other site 233413006156 GTP/Mg2+ binding site [chemical binding]; other site 233413006157 Switch I region; other site 233413006158 G2 box; other site 233413006159 G3 box; other site 233413006160 Switch II region; other site 233413006161 G4 box; other site 233413006162 G5 box; other site 233413006163 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 233413006164 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 233413006165 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 233413006166 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 233413006167 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 233413006168 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 233413006169 homodimer interface [polypeptide binding]; other site 233413006170 oligonucleotide binding site [chemical binding]; other site 233413006171 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 233413006172 active site 233413006173 multimer interface [polypeptide binding]; other site 233413006174 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 233413006175 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 233413006176 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 233413006177 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 233413006178 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 233413006179 active site 233413006180 HIGH motif; other site 233413006181 nucleotide binding site [chemical binding]; other site 233413006182 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 233413006183 active site 233413006184 KMSKS motif; other site 233413006185 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 233413006186 tRNA binding surface [nucleotide binding]; other site 233413006187 anticodon binding site; other site 233413006188 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 233413006189 Uncharacterized conserved protein [Function unknown]; Region: COG3268 233413006190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413006191 NAD(P) binding pocket [chemical binding]; other site 233413006192 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 233413006193 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 233413006194 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 233413006195 GTP binding site; other site 233413006196 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 233413006197 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 233413006198 TPP-binding site [chemical binding]; other site 233413006199 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 233413006200 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 233413006201 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 233413006202 dimer interface [polypeptide binding]; other site 233413006203 PYR/PP interface [polypeptide binding]; other site 233413006204 TPP binding site [chemical binding]; other site 233413006205 substrate binding site [chemical binding]; other site 233413006206 Major Facilitator Superfamily; Region: MFS_1; pfam07690 233413006207 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 233413006208 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 233413006209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413006210 Walker A motif; other site 233413006211 ATP binding site [chemical binding]; other site 233413006212 Walker B motif; other site 233413006213 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 233413006214 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 233413006215 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 233413006216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413006217 Major Facilitator Superfamily; Region: MFS_1; pfam07690 233413006218 putative substrate translocation pore; other site 233413006219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413006220 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 233413006221 oligomer interface [polypeptide binding]; other site 233413006222 active site residues [active] 233413006223 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 233413006224 oligomer interface [polypeptide binding]; other site 233413006225 active site residues [active] 233413006226 trigger factor; Provisional; Region: tig; PRK01490 233413006227 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 233413006228 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 233413006229 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413006230 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 233413006231 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 233413006232 putative DNA binding site [nucleotide binding]; other site 233413006233 catalytic residue [active] 233413006234 putative H2TH interface [polypeptide binding]; other site 233413006235 putative catalytic residues [active] 233413006236 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 233413006237 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 233413006238 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 233413006239 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 233413006240 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 233413006241 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 233413006242 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 233413006243 Zn binding site [ion binding]; other site 233413006244 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 233413006245 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413006246 active site 233413006247 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 233413006248 apolar tunnel; other site 233413006249 heme binding site [chemical binding]; other site 233413006250 dimerization interface [polypeptide binding]; other site 233413006251 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 233413006252 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 233413006253 active site 233413006254 catalytic site [active] 233413006255 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 233413006256 active site 233413006257 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 233413006258 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 233413006259 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413006260 Walker A/P-loop; other site 233413006261 ATP binding site [chemical binding]; other site 233413006262 Q-loop/lid; other site 233413006263 ABC transporter signature motif; other site 233413006264 Walker B; other site 233413006265 D-loop; other site 233413006266 H-loop/switch region; other site 233413006267 ABC transporter; Region: ABC_tran_2; pfam12848 233413006268 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 233413006269 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 233413006270 dimer interface [polypeptide binding]; other site 233413006271 ssDNA binding site [nucleotide binding]; other site 233413006272 tetramer (dimer of dimers) interface [polypeptide binding]; other site 233413006273 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 233413006274 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 233413006275 putative acyl-acceptor binding pocket; other site 233413006276 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 233413006277 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413006278 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 233413006279 putative acyl-acceptor binding pocket; other site 233413006280 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413006281 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413006282 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 233413006283 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413006284 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413006285 enoyl-CoA hydratase; Provisional; Region: PRK05870 233413006286 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413006287 substrate binding site [chemical binding]; other site 233413006288 oxyanion hole (OAH) forming residues; other site 233413006289 trimer interface [polypeptide binding]; other site 233413006290 Mb2512c, PE_PGRS42d, len: 274 aa. Similar to 3' end of Rv2487c, len: 694 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 274 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins, similar to many e.g. AAK47245|MT2919 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1515 (663 aa), FASTA scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d.;PE-PGRS FAMILY PROTEIN [THIRD PART] 233413006291 Mb2513c, PE_PGRS42b, len: 284 aa. Similar to middle section of Rv2487c, len: 694 aa, from Mycobacterium tuberculosis strain H37Rv, (99.3% identity in 284 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins, similar to many e.g. AAK47245|MT2919 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1515 (663 aa), FASTA scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d.;PE-PGRS FAMILY PROTEIN [SECOND PART] 233413006292 PE family; Region: PE; pfam00934 233413006293 cyclase homology domain; Region: CHD; cd07302 233413006294 nucleotidyl binding site; other site 233413006295 metal binding site [ion binding]; metal-binding site 233413006296 dimer interface [polypeptide binding]; other site 233413006297 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413006298 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 233413006299 DNA binding residues [nucleotide binding] 233413006300 dimerization interface [polypeptide binding]; other site 233413006301 PE family; Region: PE; pfam00934 233413006302 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 233413006303 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cl00358 233413006304 active site 233413006305 dimerization interface [polypeptide binding]; other site 233413006306 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413006307 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 233413006308 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 233413006309 E3 interaction surface; other site 233413006310 lipoyl attachment site [posttranslational modification]; other site 233413006311 e3 binding domain; Region: E3_binding; pfam02817 233413006312 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 233413006313 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 233413006314 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 233413006315 alpha subunit interface [polypeptide binding]; other site 233413006316 TPP binding site [chemical binding]; other site 233413006317 heterodimer interface [polypeptide binding]; other site 233413006318 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 233413006319 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 233413006320 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 233413006321 tetramer interface [polypeptide binding]; other site 233413006322 TPP-binding site [chemical binding]; other site 233413006323 heterodimer interface [polypeptide binding]; other site 233413006324 phosphorylation loop region [posttranslational modification] 233413006325 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 233413006326 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 233413006327 putative active site [active] 233413006328 putative catalytic site [active] 233413006329 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413006330 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413006331 active site 233413006332 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 233413006333 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 233413006334 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 233413006335 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 233413006336 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 233413006337 carboxyltransferase (CT) interaction site; other site 233413006338 biotinylation site [posttranslational modification]; other site 233413006339 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 233413006340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 233413006341 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 233413006342 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 233413006343 AMP-binding domain protein; Validated; Region: PRK08315 233413006344 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413006345 Helix-turn-helix domains; Region: HTH; cl00088 233413006346 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 233413006347 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 233413006348 classical (c) SDRs; Region: SDR_c; cd05233 233413006349 NAD(P) binding site [chemical binding]; other site 233413006350 active site 233413006351 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 233413006352 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 233413006353 putative active site [active] 233413006354 putative substrate binding site [chemical binding]; other site 233413006355 catalytic site [active] 233413006356 dimer interface [polypeptide binding]; other site 233413006357 Transposase, Mutator family; Region: Transposase_mut; pfam00872 233413006358 MULE transposase domain; Region: MULE; pfam10551 233413006359 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413006360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 233413006361 non-specific DNA binding site [nucleotide binding]; other site 233413006362 salt bridge; other site 233413006363 sequence-specific DNA binding site [nucleotide binding]; other site 233413006364 Domain of unknown function (DUF955); Region: DUF955; cl01076 233413006365 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 233413006366 PE family; Region: PE; pfam00934 233413006367 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 233413006368 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 233413006369 catalytic triad [active] 233413006370 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 233413006371 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 233413006372 active site 233413006373 metal binding site [ion binding]; metal-binding site 233413006374 dimer interface [polypeptide binding]; other site 233413006375 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 233413006376 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413006377 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 233413006378 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 233413006379 phosphate binding site [ion binding]; other site 233413006380 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 233413006381 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 233413006382 putative active site [active] 233413006383 putative catalytic site [active] 233413006384 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413006385 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 233413006386 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 233413006387 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 233413006388 putative NAD(P) binding site [chemical binding]; other site 233413006389 active site 233413006390 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 233413006391 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 233413006392 active site 233413006393 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 233413006394 active site 233413006395 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 233413006396 putative active site [active] 233413006397 Restriction endonuclease; Region: Mrr_cat; cl00747 233413006398 ERCC4 domain; Region: ERCC4; cl10594 233413006399 Lsr2; Region: Lsr2; pfam11774 233413006400 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413006401 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 233413006402 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 233413006403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413006404 catalytic residue [active] 233413006405 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 233413006406 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 233413006407 putative RNA binding site [nucleotide binding]; other site 233413006408 elongation factor P; Validated; Region: PRK00529 233413006409 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 233413006410 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 233413006411 RNA binding site [nucleotide binding]; other site 233413006412 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 233413006413 RNA binding site [nucleotide binding]; other site 233413006414 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 233413006415 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 233413006416 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 233413006417 active site 233413006418 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 233413006419 trimer interface [polypeptide binding]; other site 233413006420 active site 233413006421 dimer interface [polypeptide binding]; other site 233413006422 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 233413006423 active site 233413006424 dimer interface [polypeptide binding]; other site 233413006425 metal binding site [ion binding]; metal-binding site 233413006426 shikimate kinase; Reviewed; Region: aroK; PRK00131 233413006427 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 233413006428 ADP binding site [chemical binding]; other site 233413006429 magnesium binding site [ion binding]; other site 233413006430 putative shikimate binding site; other site 233413006431 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 233413006432 Tetramer interface [polypeptide binding]; other site 233413006433 active site 233413006434 FMN-binding site [chemical binding]; other site 233413006435 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 233413006436 digalactosyldiacylglycerol synthase; Region: PLN02846 233413006437 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 233413006438 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 233413006439 putative active site [active] 233413006440 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 233413006441 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; cl15444 233413006442 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 233413006443 oligomeric interface; other site 233413006444 putative active site [active] 233413006445 homodimer interface [polypeptide binding]; other site 233413006446 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413006447 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 233413006448 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 233413006449 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 233413006450 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 233413006451 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 233413006452 NAD(P) binding site [chemical binding]; other site 233413006453 shikimate binding site; other site 233413006454 YceG-like family; Region: YceG; pfam02618 233413006455 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 233413006456 dimerization interface [polypeptide binding]; other site 233413006457 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 233413006458 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 233413006459 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 233413006460 motif 1; other site 233413006461 active site 233413006462 motif 2; other site 233413006463 motif 3; other site 233413006464 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 233413006465 DHHA1 domain; Region: DHHA1; pfam02272 233413006466 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 233413006467 recombination factor protein RarA; Reviewed; Region: PRK13342 233413006468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413006469 Walker A motif; other site 233413006470 ATP binding site [chemical binding]; other site 233413006471 Walker B motif; other site 233413006472 arginine finger; other site 233413006473 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 233413006474 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 233413006475 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 233413006476 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 233413006477 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 233413006478 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 233413006479 Walker A/P-loop; other site 233413006480 ATP binding site [chemical binding]; other site 233413006481 Q-loop/lid; other site 233413006482 ABC transporter signature motif; other site 233413006483 Walker B; other site 233413006484 D-loop; other site 233413006485 H-loop/switch region; other site 233413006486 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 233413006487 ligand binding site [chemical binding]; other site 233413006488 flexible hinge region; other site 233413006489 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 233413006490 ligand binding site [chemical binding]; other site 233413006491 flexible hinge region; other site 233413006492 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 233413006493 active site 233413006494 nucleophile elbow; other site 233413006495 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 233413006496 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 233413006497 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 233413006498 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 233413006499 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 233413006500 Uncharacterized conserved protein [Function unknown]; Region: COG2308 233413006501 Domain of unknown function (DUF404); Region: DUF404; pfam04169 233413006502 Domain of unknown function (DUF407); Region: DUF407; pfam04174 233413006503 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 233413006504 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl09206 233413006505 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 233413006506 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 233413006507 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 233413006508 Protein of unknown function (DUF419); Region: DUF419; cl15265 233413006509 Predicted membrane protein [Function unknown]; Region: COG4129 233413006510 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 233413006511 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 233413006512 dimer interface [polypeptide binding]; other site 233413006513 anticodon binding site; other site 233413006514 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 233413006515 homodimer interface [polypeptide binding]; other site 233413006516 motif 1; other site 233413006517 active site 233413006518 motif 2; other site 233413006519 GAD domain; Region: GAD; pfam02938 233413006520 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 233413006521 active site 233413006522 motif 3; other site 233413006523 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 233413006524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413006525 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 233413006526 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 233413006527 putative hydrophobic ligand binding site [chemical binding]; other site 233413006528 protein interface [polypeptide binding]; other site 233413006529 gate; other site 233413006530 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 233413006531 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 233413006532 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 233413006533 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 233413006534 active site 233413006535 metal binding site [ion binding]; metal-binding site 233413006536 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 233413006537 haloalkane dehalogenase; Provisional; Region: PRK03592 233413006538 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 233413006539 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 233413006540 dimer interface [polypeptide binding]; other site 233413006541 motif 1; other site 233413006542 active site 233413006543 motif 2; other site 233413006544 motif 3; other site 233413006545 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 233413006546 anticodon binding site; other site 233413006547 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413006548 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 233413006549 active site 233413006550 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 233413006551 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 233413006552 Zn2+ binding site [ion binding]; other site 233413006553 Mg2+ binding site [ion binding]; other site 233413006554 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 233413006555 synthetase active site [active] 233413006556 NTP binding site [chemical binding]; other site 233413006557 metal binding site [ion binding]; metal-binding site 233413006558 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 233413006559 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 233413006560 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 233413006561 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 233413006562 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 233413006563 Protein export membrane protein; Region: SecD_SecF; cl14618 233413006564 protein-export membrane protein SecD; Region: secD; TIGR01129 233413006565 Protein export membrane protein; Region: SecD_SecF; cl14618 233413006566 Preprotein translocase subunit; Region: YajC; cl00806 233413006567 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 233413006568 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 233413006569 inhibitor-cofactor binding pocket; inhibition site 233413006570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413006571 catalytic residue [active] 233413006572 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 233413006573 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 233413006574 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 233413006575 putative NAD(P) binding site [chemical binding]; other site 233413006576 active site 233413006577 putative substrate binding site [chemical binding]; other site 233413006578 PE family; Region: PE; pfam00934 233413006579 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 233413006580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413006581 Walker A motif; other site 233413006582 ATP binding site [chemical binding]; other site 233413006583 Walker B motif; other site 233413006584 arginine finger; other site 233413006585 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 233413006586 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 233413006587 RuvA N terminal domain; Region: RuvA_N; pfam01330 233413006588 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 233413006589 active site 233413006590 putative DNA-binding cleft [nucleotide binding]; other site 233413006591 dimer interface [polypeptide binding]; other site 233413006592 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 233413006593 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 233413006594 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 233413006595 putative active site [active] 233413006596 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 233413006597 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 233413006598 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 233413006599 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 233413006600 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 233413006601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 233413006602 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 233413006603 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413006604 Domain of unknown function DUF28; Region: DUF28; cl00361 233413006605 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 233413006606 predicted active site [active] 233413006607 catalytic triad [active] 233413006608 acyl-CoA thioesterase II; Region: tesB; TIGR00189 233413006609 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 233413006610 active site 233413006611 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 233413006612 catalytic triad [active] 233413006613 dimer interface [polypeptide binding]; other site 233413006614 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 233413006615 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 233413006616 active site 233413006617 multimer interface [polypeptide binding]; other site 233413006618 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 233413006619 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 233413006620 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 233413006621 PPE family; Region: PPE; pfam00823 233413006622 Cutinase; Region: Cutinase; cl15711 233413006623 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 233413006624 nudix motif; other site 233413006625 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 233413006626 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 233413006627 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 233413006628 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 233413006629 putative acyl-acceptor binding pocket; other site 233413006630 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 233413006631 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 233413006632 nucleotide binding site/active site [active] 233413006633 HIT family signature motif; other site 233413006634 catalytic residue [active] 233413006635 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 233413006636 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 233413006637 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 233413006638 active site 233413006639 dimer interface [polypeptide binding]; other site 233413006640 motif 1; other site 233413006641 motif 2; other site 233413006642 motif 3; other site 233413006643 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 233413006644 anticodon binding site; other site 233413006645 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 233413006646 PE family; Region: PE; pfam00934 233413006647 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 233413006648 Predicted transcriptional regulator [Transcription]; Region: COG2345 233413006649 Helix-turn-helix domains; Region: HTH; cl00088 233413006650 Cupin domain; Region: Cupin_2; cl09118 233413006651 Predicted transcriptional regulator [Transcription]; Region: COG2345 233413006652 Helix-turn-helix domains; Region: HTH; cl00088 233413006653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413006654 S-adenosylmethionine binding site [chemical binding]; other site 233413006655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413006656 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 233413006657 Ligand Binding Site [chemical binding]; other site 233413006658 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 233413006659 Ligand Binding Site [chemical binding]; other site 233413006660 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 233413006661 Ligand Binding Site [chemical binding]; other site 233413006662 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 233413006663 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 233413006664 active site 233413006665 putative substrate binding region [chemical binding]; other site 233413006666 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 233413006667 FOG: CBS domain [General function prediction only]; Region: COG0517 233413006668 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 233413006669 peptide chain release factor 1; Provisional; Region: PRK04011 233413006670 Archease protein family (DUF101/UPF0211); Region: Archease; cl00606 233413006671 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 233413006672 hypothetical protein; Reviewed; Region: PRK09588 233413006673 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 233413006674 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 233413006675 PE family; Region: PE; pfam00934 233413006676 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 233413006677 P-loop motif; other site 233413006678 ATP binding site [chemical binding]; other site 233413006679 Chloramphenicol (Cm) binding site [chemical binding]; other site 233413006680 catalytic residue [active] 233413006681 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 233413006682 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 233413006683 anti sigma factor interaction site; other site 233413006684 regulatory phosphorylation site [posttranslational modification]; other site 233413006685 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 233413006686 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 233413006687 putative DNA binding site [nucleotide binding]; other site 233413006688 putative Zn2+ binding site [ion binding]; other site 233413006689 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 233413006690 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 233413006691 putative metal binding site [ion binding]; other site 233413006692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 233413006693 dimerization interface [polypeptide binding]; other site 233413006694 putative DNA binding site [nucleotide binding]; other site 233413006695 putative Zn2+ binding site [ion binding]; other site 233413006696 Membrane transport protein; Region: Mem_trans; cl09117 233413006697 Low molecular weight phosphatase family; Region: LMWPc; cd00115 233413006698 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 233413006699 active site 233413006700 Transposase, Mutator family; Region: Transposase_mut; pfam00872 233413006701 MULE transposase domain; Region: MULE; pfam10551 233413006702 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 233413006703 Clp amino terminal domain; Region: Clp_N; pfam02861 233413006704 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 233413006705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 233413006706 Coenzyme A binding pocket [chemical binding]; other site 233413006707 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 233413006708 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 233413006709 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 233413006710 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413006711 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 233413006712 SelR domain; Region: SelR; cl00369 233413006713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413006714 S-adenosylmethionine binding site [chemical binding]; other site 233413006715 Chlorite dismutase; Region: Chlor_dismutase; cl01280 233413006716 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 233413006717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413006718 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 233413006719 substrate binding site [chemical binding]; other site 233413006720 active site 233413006721 enoyl-CoA hydratase; Provisional; Region: PRK07327 233413006722 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413006723 substrate binding site [chemical binding]; other site 233413006724 oxyanion hole (OAH) forming residues; other site 233413006725 trimer interface [polypeptide binding]; other site 233413006726 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 233413006727 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 233413006728 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 233413006729 putative active site [active] 233413006730 catalytic site [active] 233413006731 putative substrate binding site [chemical binding]; other site 233413006732 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 233413006733 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 233413006734 TPP-binding site; other site 233413006735 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 233413006736 PYR/PP interface [polypeptide binding]; other site 233413006737 dimer interface [polypeptide binding]; other site 233413006738 TPP binding site [chemical binding]; other site 233413006739 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 233413006740 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 233413006741 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 233413006742 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 233413006743 transmembrane helices; other site 233413006744 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 233413006745 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 233413006746 transmembrane helices; other site 233413006747 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 233413006748 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 233413006749 Walker A/P-loop; other site 233413006750 ATP binding site [chemical binding]; other site 233413006751 Q-loop/lid; other site 233413006752 ABC transporter signature motif; other site 233413006753 Walker B; other site 233413006754 D-loop; other site 233413006755 H-loop/switch region; other site 233413006756 TRAM domain; Region: TRAM; cl01282 233413006757 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 233413006758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413006759 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 233413006760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413006761 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 233413006762 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 233413006763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413006764 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 233413006765 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 233413006766 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 233413006767 generic binding surface II; other site 233413006768 ssDNA binding site; other site 233413006769 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 233413006770 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 233413006771 trimer interface [polypeptide binding]; other site 233413006772 active site 233413006773 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 233413006774 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 233413006775 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 233413006776 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 233413006777 active site 233413006778 dimerization interface [polypeptide binding]; other site 233413006779 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 233413006780 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 233413006781 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 233413006782 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 233413006783 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 233413006784 DNA binding residues [nucleotide binding] 233413006785 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 233413006786 homotrimer interaction site [polypeptide binding]; other site 233413006787 putative active site [active] 233413006788 Protein of unknown function (DUF952); Region: DUF952; cl01393 233413006789 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 233413006790 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 233413006791 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 233413006792 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 233413006793 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 233413006794 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 233413006795 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 233413006796 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 233413006797 DNA binding residues [nucleotide binding] 233413006798 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 233413006799 Helix-turn-helix domains; Region: HTH; cl00088 233413006800 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 233413006801 FeoA domain; Region: FeoA; cl00838 233413006802 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 233413006803 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 233413006804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413006805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413006806 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 233413006807 PAC2 family; Region: PAC2; cl00847 233413006808 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413006809 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413006810 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 233413006811 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 233413006812 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 233413006813 heme-binding site [chemical binding]; other site 233413006814 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 233413006815 ATP cone domain; Region: ATP-cone; pfam03477 233413006816 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 233413006817 Helix-turn-helix domains; Region: HTH; cl00088 233413006818 LexA repressor; Validated; Region: PRK00215 233413006819 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 233413006820 Catalytic site [active] 233413006821 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 233413006822 LGFP repeat; Region: LGFP; pfam08310 233413006823 LGFP repeat; Region: LGFP; pfam08310 233413006824 LGFP repeat; Region: LGFP; pfam08310 233413006825 LGFP repeat; Region: LGFP; pfam08310 233413006826 LGFP repeat; Region: LGFP; pfam08310 233413006827 Integral membrane protein TerC family; Region: TerC; cl10468 233413006828 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413006829 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413006830 active site 233413006831 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 233413006832 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 233413006833 HflX GTPase family; Region: HflX; cd01878 233413006834 G1 box; other site 233413006835 GTP/Mg2+ binding site [chemical binding]; other site 233413006836 Switch I region; other site 233413006837 G2 box; other site 233413006838 G3 box; other site 233413006839 Switch II region; other site 233413006840 G4 box; other site 233413006841 G5 box; other site 233413006842 diaminopimelate epimerase; Region: DapF; TIGR00652 233413006843 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 233413006844 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 233413006845 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 233413006846 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413006847 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 233413006848 active site 233413006849 metal binding site [ion binding]; metal-binding site 233413006850 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 233413006851 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 233413006852 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 233413006853 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 233413006854 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 233413006855 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413006856 FeS/SAM binding site; other site 233413006857 TRAM domain; Region: TRAM; cl01282 233413006858 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 233413006859 RecX family; Region: RecX; cl00936 233413006860 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 233413006861 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 233413006862 hexamer interface [polypeptide binding]; other site 233413006863 Walker A motif; other site 233413006864 ATP binding site [chemical binding]; other site 233413006865 Walker B motif; other site 233413006866 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 233413006867 thioester formation/cholesterol transfer; other site 233413006868 protein-splicing catalytic site; other site 233413006869 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413006870 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 233413006871 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 233413006872 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 233413006873 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 233413006874 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 233413006875 PE family; Region: PE; pfam00934 233413006876 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 233413006877 PspA/IM30 family; Region: PspA_IM30; pfam04012 233413006878 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 233413006879 non-specific DNA binding site [nucleotide binding]; other site 233413006880 salt bridge; other site 233413006881 sequence-specific DNA binding site [nucleotide binding]; other site 233413006882 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 233413006883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 233413006884 Coenzyme A binding pocket [chemical binding]; other site 233413006885 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413006886 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 233413006887 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 233413006888 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 233413006889 classical (c) SDRs; Region: SDR_c; cd05233 233413006890 NAD(P) binding site [chemical binding]; other site 233413006891 active site 233413006892 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413006893 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 233413006894 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413006895 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 233413006896 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 233413006897 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 233413006898 dimer interface [polypeptide binding]; other site 233413006899 active site 233413006900 catalytic residue [active] 233413006901 Thymidylate synthase complementing protein; Region: Thy1; cl03630 233413006902 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 233413006903 HsdM N-terminal domain; Region: HsdM_N; pfam12161 233413006904 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 233413006905 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 233413006906 putative active site [active] 233413006907 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 233413006908 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 233413006909 putative active site [active] 233413006910 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 233413006911 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 233413006912 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 233413006913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 233413006914 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 233413006915 folate binding site [chemical binding]; other site 233413006916 NADP+ binding site [chemical binding]; other site 233413006917 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 233413006918 dimerization interface [polypeptide binding]; other site 233413006919 active site 233413006920 Dienelactone hydrolase family; Region: DLH; pfam01738 233413006921 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 233413006922 classical (c) SDRs; Region: SDR_c; cd05233 233413006923 NAD(P) binding site [chemical binding]; other site 233413006924 active site 233413006925 PPE family; Region: PPE; pfam00823 233413006926 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413006927 PE family; Region: PE; pfam00934 233413006928 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413006929 PPE family; Region: PPE; pfam00823 233413006930 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413006931 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 233413006932 dihydrodipicolinate reductase; Provisional; Region: PRK00048 233413006933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413006934 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 233413006935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 233413006936 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 233413006937 Coenzyme A binding pocket [chemical binding]; other site 233413006938 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 233413006939 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 233413006940 FMN-binding pocket [chemical binding]; other site 233413006941 flavin binding motif; other site 233413006942 phosphate binding motif [ion binding]; other site 233413006943 beta-alpha-beta structure motif; other site 233413006944 NAD binding pocket [chemical binding]; other site 233413006945 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 233413006946 catalytic loop [active] 233413006947 iron binding site [ion binding]; other site 233413006948 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 233413006949 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 233413006950 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 233413006951 hydrophobic ligand binding site; other site 233413006952 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 233413006953 Helix-turn-helix domains; Region: HTH; cl00088 233413006954 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 233413006955 alanine dehydrogenase; Region: alaDH; TIGR00518 233413006956 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 233413006957 NAD(P) binding site [chemical binding]; other site 233413006958 Nitronate monooxygenase; Region: NMO; pfam03060 233413006959 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 233413006960 FMN binding site [chemical binding]; other site 233413006961 substrate binding site [chemical binding]; other site 233413006962 putative catalytic residue [active] 233413006963 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 233413006964 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 233413006965 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 233413006966 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 233413006967 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 233413006968 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 233413006969 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 233413006970 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 233413006971 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 233413006972 putative nucleic acid binding region [nucleotide binding]; other site 233413006973 G-X-X-G motif; other site 233413006974 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 233413006975 RNA binding site [nucleotide binding]; other site 233413006976 domain interface; other site 233413006977 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 233413006978 16S/18S rRNA binding site [nucleotide binding]; other site 233413006979 S13e-L30e interaction site [polypeptide binding]; other site 233413006980 25S rRNA binding site [nucleotide binding]; other site 233413006981 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 233413006982 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 233413006983 active site 233413006984 Riboflavin kinase; Region: Flavokinase; cl03312 233413006985 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 233413006986 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 233413006987 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 233413006988 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 233413006989 Helix-turn-helix domains; Region: HTH; cl00088 233413006990 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 233413006991 FeoA domain; Region: FeoA; cl00838 233413006992 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413006993 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413006994 active site 233413006995 lipid-transfer protein; Provisional; Region: PRK08256 233413006996 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 233413006997 active site 233413006998 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 233413006999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 233413007000 Probable transposase; Region: OrfB_IS605; pfam01385 233413007001 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 233413007002 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 233413007003 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 233413007004 catalytic residues [active] 233413007005 catalytic nucleophile [active] 233413007006 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 233413007007 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 233413007008 RNA binding site [nucleotide binding]; other site 233413007009 active site 233413007010 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 233413007011 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 233413007012 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 233413007013 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 233413007014 active site 233413007015 metal binding site [ion binding]; metal-binding site 233413007016 Uncharacterized conserved protein [Function unknown]; Region: COG4717 233413007017 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 233413007018 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 233413007019 Predicted acyl esterases [General function prediction only]; Region: COG2936 233413007020 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 233413007021 PemK-like protein; Region: PemK; cl00995 233413007022 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 233413007023 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 233413007024 Integrase core domain; Region: rve; cl01316 233413007025 Mb2833c, -, len: 133 aa. Equivalent to Rv2810c, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 133 aa overlap). Probable transposase for IS1555, similar to C-terminal domain of transposases for defective IS1555 e.g. Q9LCS0|TNPA TRANSPOSASE from Arthrobacter sp. TM1 (435 aa), FASTA scores: opt: 294, E(): 1.8e-13, (55.1% identity in 98 aa overlap); Q50440|TNPA INSERTION ELEMENT TNPR AND TNPA GENE from Mycobacterium smegmatis (413 aa), FASTA scores: opt: 274, E(): 4.7e-12, (56.25% identity in 96 aa overlap); etc.;PROBABLE TRANSPOSASE 233413007026 Integrase core domain; Region: rve; cl01316 233413007027 Integrase core domain; Region: rve; cl01316 233413007028 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 233413007029 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 233413007030 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413007031 putative transposase OrfB; Reviewed; Region: PHA02517 233413007032 Integrase core domain; Region: rve; cl01316 233413007033 Helix-turn-helix domains; Region: HTH; cl00088 233413007034 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 233413007035 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 233413007036 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 233413007037 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 233413007038 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 233413007039 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 233413007040 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 233413007041 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 233413007042 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 233413007043 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 233413007044 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 233413007045 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 233413007046 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 233413007047 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 233413007048 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 233413007049 putative active site [active] 233413007050 Phd_YefM; Region: PhdYeFM; cl09153 233413007051 enoyl-CoA hydratase; Provisional; Region: PRK06190 233413007052 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413007053 substrate binding site [chemical binding]; other site 233413007054 oxyanion hole (OAH) forming residues; other site 233413007055 trimer interface [polypeptide binding]; other site 233413007056 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 233413007057 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 233413007058 Walker A/P-loop; other site 233413007059 ATP binding site [chemical binding]; other site 233413007060 Q-loop/lid; other site 233413007061 ABC transporter signature motif; other site 233413007062 Walker B; other site 233413007063 D-loop; other site 233413007064 H-loop/switch region; other site 233413007065 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 233413007066 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 233413007067 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 233413007068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413007069 dimer interface [polypeptide binding]; other site 233413007070 conserved gate region; other site 233413007071 putative PBP binding loops; other site 233413007072 ABC-ATPase subunit interface; other site 233413007073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413007074 putative PBP binding loops; other site 233413007075 dimer interface [polypeptide binding]; other site 233413007076 ABC-ATPase subunit interface; other site 233413007077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 233413007078 putative efflux protein, MATE family; Region: matE; TIGR00797 233413007079 MatE; Region: MatE; cl10513 233413007080 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 233413007081 DHH family; Region: DHH; pfam01368 233413007082 Ribosome-binding factor A; Region: RBFA; cl00542 233413007083 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 233413007084 translation initiation factor IF-2; Region: IF-2; TIGR00487 233413007085 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 233413007086 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 233413007087 G1 box; other site 233413007088 putative GEF interaction site [polypeptide binding]; other site 233413007089 GTP/Mg2+ binding site [chemical binding]; other site 233413007090 Switch I region; other site 233413007091 G2 box; other site 233413007092 G3 box; other site 233413007093 Switch II region; other site 233413007094 G4 box; other site 233413007095 G5 box; other site 233413007096 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 233413007097 Translation-initiation factor 2; Region: IF-2; pfam11987 233413007098 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 233413007099 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 233413007100 putative RNA binding cleft [nucleotide binding]; other site 233413007101 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 233413007102 NusA N-terminal domain; Region: NusA_N; pfam08529 233413007103 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 233413007104 RNA binding site [nucleotide binding]; other site 233413007105 homodimer interface [polypeptide binding]; other site 233413007106 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 233413007107 G-X-X-G motif; other site 233413007108 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 233413007109 G-X-X-G motif; other site 233413007110 ribosome maturation protein RimP; Reviewed; Region: PRK00092 233413007111 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 233413007112 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 233413007113 Sm1 motif; other site 233413007114 D3 - B interaction site; other site 233413007115 D1 - D2 interaction site; other site 233413007116 Hfq - Hfq interaction site; other site 233413007117 RNA binding pocket [nucleotide binding]; other site 233413007118 Sm2 motif; other site 233413007119 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 233413007120 dinuclear metal binding motif [ion binding]; other site 233413007121 prolyl-tRNA synthetase; Provisional; Region: PRK09194 233413007122 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 233413007123 dimer interface [polypeptide binding]; other site 233413007124 motif 1; other site 233413007125 active site 233413007126 motif 2; other site 233413007127 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 233413007128 putative deacylase active site [active] 233413007129 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 233413007130 active site 233413007131 motif 3; other site 233413007132 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 233413007133 anticodon binding site; other site 233413007134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413007135 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 233413007136 putative substrate translocation pore; other site 233413007137 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 233413007138 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 233413007139 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 233413007140 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413007141 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 233413007142 catalytic triad [active] 233413007143 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 233413007144 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 233413007145 homodimer interface [polypeptide binding]; other site 233413007146 Walker A motif; other site 233413007147 ATP binding site [chemical binding]; other site 233413007148 hydroxycobalamin binding site [chemical binding]; other site 233413007149 Walker B motif; other site 233413007150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413007151 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 233413007152 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 233413007153 metal ion-dependent adhesion site (MIDAS); other site 233413007154 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 233413007155 Predicted dehydrogenase [General function prediction only]; Region: COG0579 233413007156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007157 PE family; Region: PE; pfam00934 233413007158 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 233413007159 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413007160 mycothione reductase; Reviewed; Region: PRK07846 233413007161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007162 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 233413007163 High-affinity nickel-transport protein; Region: NicO; cl00964 233413007164 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 233413007165 classical (c) SDRs; Region: SDR_c; cd05233 233413007166 NAD(P) binding site [chemical binding]; other site 233413007167 active site 233413007168 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 233413007169 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 233413007170 NAD(P) binding site [chemical binding]; other site 233413007171 catalytic residues [active] 233413007172 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 233413007173 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 233413007174 catalytic triad [active] 233413007175 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 233413007176 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 233413007177 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 233413007178 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 233413007179 active site 233413007180 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 233413007181 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 233413007182 putative active site [active] 233413007183 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 233413007184 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 233413007185 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413007186 Phd_YefM; Region: PhdYeFM; cl09153 233413007187 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 233413007188 Predicted acetyltransferase [General function prediction only]; Region: COG3393 233413007189 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 233413007190 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 233413007191 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 233413007192 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 233413007193 active site 233413007194 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 233413007195 protein binding site [polypeptide binding]; other site 233413007196 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 233413007197 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 233413007198 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 233413007199 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 233413007200 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413007201 Fasciclin domain; Region: Fasciclin; cl02663 233413007202 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 233413007203 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 233413007204 catalytic residues [active] 233413007205 Fasciclin domain; Region: Fasciclin; cl02663 233413007206 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 233413007207 LysE type translocator; Region: LysE; cl00565 233413007208 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 233413007209 catalytic residues [active] 233413007210 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 233413007211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413007212 FeS/SAM binding site; other site 233413007213 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 233413007214 ribosome recycling factor; Reviewed; Region: frr; PRK00083 233413007215 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 233413007216 hinge region; other site 233413007217 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 233413007218 putative nucleotide binding site [chemical binding]; other site 233413007219 uridine monophosphate binding site [chemical binding]; other site 233413007220 homohexameric interface [polypeptide binding]; other site 233413007221 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 233413007222 DNA binding site [nucleotide binding] 233413007223 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 233413007224 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 233413007225 Probable transposase; Region: OrfB_IS605; pfam01385 233413007226 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 233413007227 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 233413007228 catalytic residues [active] 233413007229 catalytic nucleophile [active] 233413007230 Helix-turn-helix domains; Region: HTH; cl00088 233413007231 amidase; Provisional; Region: PRK07869 233413007232 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 233413007233 elongation factor Ts; Provisional; Region: tsf; PRK09377 233413007234 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 233413007235 Elongation factor TS; Region: EF_TS; pfam00889 233413007236 Elongation factor TS; Region: EF_TS; pfam00889 233413007237 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 233413007238 rRNA interaction site [nucleotide binding]; other site 233413007239 S8 interaction site; other site 233413007240 putative laminin-1 binding site; other site 233413007241 Peptidase family M23; Region: Peptidase_M23; pfam01551 233413007242 PPE family; Region: PPE; pfam00823 233413007243 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413007244 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 233413007245 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 233413007246 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 233413007247 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 233413007248 DNA binding site [nucleotide binding] 233413007249 Int/Topo IB signature motif; other site 233413007250 active site 233413007251 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 233413007252 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 233413007253 FAD binding pocket [chemical binding]; other site 233413007254 FAD binding motif [chemical binding]; other site 233413007255 phosphate binding motif [ion binding]; other site 233413007256 NAD binding pocket [chemical binding]; other site 233413007257 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 233413007258 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 233413007259 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 233413007260 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 233413007261 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413007262 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 233413007263 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 233413007264 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 233413007265 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 233413007266 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 233413007267 putative molybdopterin cofactor binding site [chemical binding]; other site 233413007268 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 233413007269 putative molybdopterin cofactor binding site; other site 233413007270 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 233413007271 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 233413007272 RNA/DNA hybrid binding site [nucleotide binding]; other site 233413007273 active site 233413007274 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 233413007275 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 233413007276 Catalytic site [active] 233413007277 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 233413007278 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 233413007279 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413007280 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 233413007281 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 233413007282 RimM N-terminal domain; Region: RimM; pfam01782 233413007283 hypothetical protein; Provisional; Region: PRK00468; cl00794 233413007284 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 233413007285 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 233413007286 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 233413007287 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413007288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413007289 Helix-turn-helix domains; Region: HTH; cl00088 233413007290 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 233413007291 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 233413007292 active site 233413007293 putative substrate binding pocket [chemical binding]; other site 233413007294 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 233413007295 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 233413007296 Catalytic domain of Protein Kinases; Region: PKc; cd00180 233413007297 active site 233413007298 ATP binding site [chemical binding]; other site 233413007299 substrate binding site [chemical binding]; other site 233413007300 activation loop (A-loop); other site 233413007301 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 233413007302 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 233413007303 active site 233413007304 signal recognition particle protein; Provisional; Region: PRK10867 233413007305 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 233413007306 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 233413007307 P loop; other site 233413007308 GTP binding site [chemical binding]; other site 233413007309 Signal peptide binding domain; Region: SRP_SPB; pfam02978 233413007310 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 233413007311 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 233413007312 ATP binding site [chemical binding]; other site 233413007313 putative Mg++ binding site [ion binding]; other site 233413007314 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 233413007315 ATP-binding site [chemical binding]; other site 233413007316 PII uridylyl-transferase; Provisional; Region: PRK03381 233413007317 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 233413007318 metal binding triad; other site 233413007319 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 233413007320 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 233413007321 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 233413007322 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 233413007323 Nitrogen regulatory protein P-II; Region: P-II; cl00412 233413007324 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 233413007325 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 233413007326 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 233413007327 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413007328 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 233413007329 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 233413007330 Walker A/P-loop; other site 233413007331 ATP binding site [chemical binding]; other site 233413007332 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 233413007333 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 233413007334 ABC transporter signature motif; other site 233413007335 Walker B; other site 233413007336 D-loop; other site 233413007337 H-loop/switch region; other site 233413007338 Acylphosphatase; Region: Acylphosphatase; cl00551 233413007339 OsmC-like protein; Region: OsmC; cl00767 233413007340 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 233413007341 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 233413007342 DNA binding site [nucleotide binding] 233413007343 catalytic residue [active] 233413007344 H2TH interface [polypeptide binding]; other site 233413007345 putative catalytic residues [active] 233413007346 turnover-facilitating residue; other site 233413007347 intercalation triad [nucleotide binding]; other site 233413007348 8OG recognition residue [nucleotide binding]; other site 233413007349 putative reading head residues; other site 233413007350 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 233413007351 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 233413007352 ribonuclease III; Reviewed; Region: rnc; PRK00102 233413007353 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 233413007354 dimerization interface [polypeptide binding]; other site 233413007355 active site 233413007356 metal binding site [ion binding]; metal-binding site 233413007357 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 233413007358 dsRNA binding site [nucleotide binding]; other site 233413007359 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 233413007360 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 233413007361 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 233413007362 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 233413007363 acyl-CoA synthetase; Validated; Region: PRK05850 233413007364 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413007365 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413007366 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 233413007367 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413007368 active site 233413007369 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413007370 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 233413007371 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 233413007372 NADP binding site [chemical binding]; other site 233413007373 active site 233413007374 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413007375 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413007376 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 233413007377 active site 233413007378 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413007379 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 233413007380 NADP binding site [chemical binding]; other site 233413007381 active site 233413007382 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413007383 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 233413007384 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413007385 active site 233413007386 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413007387 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 233413007388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007389 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 233413007390 Enoylreductase; Region: PKS_ER; smart00829 233413007391 NAD(P) binding site [chemical binding]; other site 233413007392 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 233413007393 putative NADP binding site [chemical binding]; other site 233413007394 active site 233413007395 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413007396 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 233413007397 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413007398 active site 233413007399 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413007400 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 233413007401 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 233413007402 putative NADP binding site [chemical binding]; other site 233413007403 active site 233413007404 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413007405 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 233413007406 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413007407 active site 233413007408 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413007409 peptide synthase; Validated; Region: PRK05691 233413007410 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413007411 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 233413007412 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413007413 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 233413007414 Walker A/P-loop; other site 233413007415 ATP binding site [chemical binding]; other site 233413007416 Q-loop/lid; other site 233413007417 ABC transporter signature motif; other site 233413007418 Walker B; other site 233413007419 D-loop; other site 233413007420 H-loop/switch region; other site 233413007421 ABC-2 type transporter; Region: ABC2_membrane; cl11417 233413007422 ABC-2 type transporter; Region: ABC2_membrane; cl11417 233413007423 acyltransferase PapA5; Provisional; Region: PRK09294 233413007424 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 233413007425 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413007426 active site 233413007427 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413007428 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 233413007429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007430 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 233413007431 Enoylreductase; Region: PKS_ER; smart00829 233413007432 NAD(P) binding site [chemical binding]; other site 233413007433 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 233413007434 putative NADP binding site [chemical binding]; other site 233413007435 active site 233413007436 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413007437 acyl-CoA synthetase; Validated; Region: PRK05850 233413007438 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413007439 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 233413007440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 233413007441 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 233413007442 Integrase core domain; Region: rve; cl01316 233413007443 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413007444 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 233413007445 Erythronolide synthase docking; Region: Docking; pfam08990 233413007446 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 233413007447 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413007448 active site 233413007449 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413007450 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 233413007451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007452 Enoylreductase; Region: PKS_ER; smart00829 233413007453 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 233413007454 NAD(P) binding site [chemical binding]; other site 233413007455 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 233413007456 putative NADP binding site [chemical binding]; other site 233413007457 active site 233413007458 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413007459 acyl-CoA synthetase; Validated; Region: PRK06060 233413007460 AMP-binding enzyme; Region: AMP-binding; cl15778 233413007461 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 233413007462 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413007463 UTRA domain; Region: UTRA; cl01230 233413007464 acyl-CoA synthetase; Validated; Region: PRK05850 233413007465 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413007466 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 233413007467 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 233413007468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413007469 S-adenosylmethionine binding site [chemical binding]; other site 233413007470 RNA polymerase sigma factor; Reviewed; Region: PRK05602 233413007471 Uncharacterized conserved protein [Function unknown]; Region: COG3268 233413007472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413007474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413007475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413007476 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 233413007477 metal-binding site 233413007478 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 233413007479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007480 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 233413007481 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 233413007482 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 233413007483 active site 233413007484 TDP-binding site; other site 233413007485 acceptor substrate-binding pocket; other site 233413007486 Predicted permease; Region: DUF318; cl00487 233413007487 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 233413007488 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 233413007489 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 233413007490 putative active site [active] 233413007491 putative substrate binding site [chemical binding]; other site 233413007492 putative cosubstrate binding site; other site 233413007493 catalytic site [active] 233413007494 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 233413007495 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 233413007496 active site 233413007497 (T/H)XGH motif; other site 233413007498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413007499 S-adenosylmethionine binding site [chemical binding]; other site 233413007500 pyruvate carboxylase; Reviewed; Region: PRK12999 233413007501 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 233413007502 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 233413007503 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 233413007504 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 233413007505 active site 233413007506 catalytic residues [active] 233413007507 metal binding site [ion binding]; metal-binding site 233413007508 homodimer binding site [polypeptide binding]; other site 233413007509 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 233413007510 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 233413007511 carboxyltransferase (CT) interaction site; other site 233413007512 biotinylation site [posttranslational modification]; other site 233413007513 Vitamin K epoxide reductase family; Region: VKOR; cl01729 233413007514 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 233413007515 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413007516 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 233413007517 substrate binding pocket [chemical binding]; other site 233413007518 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 233413007519 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 233413007520 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 233413007521 active site 233413007522 catalytic tetrad [active] 233413007523 Protein of unknown function DUF262; Region: DUF262; cl14890 233413007524 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 233413007525 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 233413007526 generic binding surface II; other site 233413007527 ssDNA binding site; other site 233413007528 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 233413007529 ATP binding site [chemical binding]; other site 233413007530 putative Mg++ binding site [ion binding]; other site 233413007531 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 233413007532 nucleotide binding region [chemical binding]; other site 233413007533 ATP-binding site [chemical binding]; other site 233413007534 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 233413007535 DAK2 domain; Region: Dak2; cl03685 233413007536 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 233413007537 ligand binding site [chemical binding]; other site 233413007538 active site 233413007539 UGI interface [polypeptide binding]; other site 233413007540 catalytic site [active] 233413007541 thiamine monophosphate kinase; Provisional; Region: PRK05731 233413007542 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 233413007543 ATP binding site [chemical binding]; other site 233413007544 dimerization interface [polypeptide binding]; other site 233413007545 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 233413007546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 233413007547 Probable transposase; Region: OrfB_IS605; pfam01385 233413007548 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 233413007549 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 233413007550 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 233413007551 catalytic residues [active] 233413007552 catalytic nucleophile [active] 233413007553 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 233413007554 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 233413007555 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 233413007556 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 233413007557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007558 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 233413007559 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 233413007560 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 233413007561 polyphosphate kinase; Provisional; Region: PRK05443 233413007562 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 233413007563 putative domain interface [polypeptide binding]; other site 233413007564 putative active site [active] 233413007565 catalytic site [active] 233413007566 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 233413007567 putative domain interface [polypeptide binding]; other site 233413007568 putative active site [active] 233413007569 catalytic site [active] 233413007570 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 233413007571 active site 233413007572 Ap6A binding site [chemical binding]; other site 233413007573 nudix motif; other site 233413007574 metal binding site [ion binding]; metal-binding site 233413007575 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 233413007576 catalytic core [active] 233413007577 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 233413007578 IHF - DNA interface [nucleotide binding]; other site 233413007579 IHF dimer interface [polypeptide binding]; other site 233413007580 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 233413007581 substrate binding site [chemical binding]; other site 233413007582 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 233413007583 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 233413007584 substrate binding site [chemical binding]; other site 233413007585 ligand binding site [chemical binding]; other site 233413007586 Helix-turn-helix domains; Region: HTH; cl00088 233413007587 Transcriptional regulator [Transcription]; Region: IclR; COG1414 233413007588 Bacterial transcriptional regulator; Region: IclR; pfam01614 233413007589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413007590 S-adenosylmethionine binding site [chemical binding]; other site 233413007591 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 233413007592 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 233413007593 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 233413007594 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 233413007595 active site 233413007596 HIGH motif; other site 233413007597 nucleotide binding site [chemical binding]; other site 233413007598 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 233413007599 active site 233413007600 KMSKS motif; other site 233413007601 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 233413007602 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 233413007603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413007604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 233413007605 putative substrate translocation pore; other site 233413007606 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 233413007607 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 233413007608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007609 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 233413007610 putative L-serine binding site [chemical binding]; other site 233413007611 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 233413007612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 233413007614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 233413007615 phosphorylation site [posttranslational modification] 233413007616 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 233413007617 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 233413007618 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413007619 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 233413007620 Walker A/P-loop; other site 233413007621 ATP binding site [chemical binding]; other site 233413007622 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 233413007623 ketol-acid reductoisomerase; Provisional; Region: PRK05479 233413007624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007625 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 233413007626 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 233413007627 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 233413007628 putative valine binding site [chemical binding]; other site 233413007629 dimer interface [polypeptide binding]; other site 233413007630 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 233413007631 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 233413007632 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 233413007633 PYR/PP interface [polypeptide binding]; other site 233413007634 dimer interface [polypeptide binding]; other site 233413007635 TPP binding site [chemical binding]; other site 233413007636 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 233413007637 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 233413007638 TPP-binding site [chemical binding]; other site 233413007639 dimer interface [polypeptide binding]; other site 233413007640 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 233413007641 DoxX; Region: DoxX; cl00976 233413007642 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 233413007643 Flavin Reductases; Region: FlaRed; cl00801 233413007644 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 233413007645 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 233413007646 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 233413007647 GatB domain; Region: GatB_Yqey; cl11497 233413007648 6-phosphofructokinase; Provisional; Region: PRK03202 233413007649 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 233413007650 active site 233413007651 ADP/pyrophosphate binding site [chemical binding]; other site 233413007652 dimerization interface [polypeptide binding]; other site 233413007653 allosteric effector site; other site 233413007654 fructose-1,6-bisphosphate binding site; other site 233413007655 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 233413007656 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 233413007657 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 233413007658 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 233413007659 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 233413007660 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 233413007661 nucleotide binding pocket [chemical binding]; other site 233413007662 K-X-D-G motif; other site 233413007663 catalytic site [active] 233413007664 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 233413007665 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 233413007666 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 233413007667 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 233413007668 Dimer interface [polypeptide binding]; other site 233413007669 BRCT sequence motif; other site 233413007670 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 233413007671 PknH-like extracellular domain; Region: PknH_C; pfam14032 233413007672 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413007673 PPE family; Region: PPE; pfam00823 233413007674 similar to PE family protein; Mb3044c, PE27A, len: 28 aa. Equivalent to Rv3018A, len: 28 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 28 aa overlap). Member of M. tuberculosis PE family, most similar to Rv0285 (102 aa), FASTA scores: opt: 147, E(): 3.5e-05, (92.85% identity in 28 aa overlap); etc. 233413007675 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413007676 PPE family; Region: PPE; pfam00823 233413007677 Transposase, Mutator family; Region: Transposase_mut; pfam00872 233413007678 MULE transposase domain; Region: MULE; pfam10551 233413007679 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 233413007680 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 233413007681 Ligand Binding Site [chemical binding]; other site 233413007682 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 233413007683 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 233413007684 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413007685 catalytic residue [active] 233413007686 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 233413007687 putative acyl-acceptor binding pocket; other site 233413007688 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 233413007689 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 233413007690 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 233413007691 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 233413007692 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 233413007693 Ligand binding site [chemical binding]; other site 233413007694 Electron transfer flavoprotein domain; Region: ETF; pfam01012 233413007695 tocopherol O-methyltransferase; Region: PLN02244 233413007696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413007697 S-adenosylmethionine binding site [chemical binding]; other site 233413007698 Uncharacterized conserved protein [Function unknown]; Region: COG1543 233413007699 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 233413007700 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 233413007701 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 233413007702 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 233413007703 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 233413007704 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 233413007705 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 233413007706 trimer interface [polypeptide binding]; other site 233413007707 active site 233413007708 substrate binding site [chemical binding]; other site 233413007709 CoA binding site [chemical binding]; other site 233413007710 FOG: WD40-like repeat [Function unknown]; Region: COG1520 233413007711 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 233413007712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413007713 S-adenosylmethionine binding site [chemical binding]; other site 233413007714 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413007715 substrate binding site [chemical binding]; other site 233413007716 oxyanion hole (OAH) forming residues; other site 233413007717 trimer interface [polypeptide binding]; other site 233413007718 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 233413007719 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413007720 Walker A/P-loop; other site 233413007721 ATP binding site [chemical binding]; other site 233413007722 Q-loop/lid; other site 233413007723 ABC transporter signature motif; other site 233413007724 Walker B; other site 233413007725 D-loop; other site 233413007726 H-loop/switch region; other site 233413007727 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 233413007728 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 233413007729 phosphoserine phosphatase SerB; Region: serB; TIGR00338 233413007730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 233413007731 motif II; other site 233413007732 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 233413007733 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 233413007734 D-pathway; other site 233413007735 Putative ubiquinol binding site [chemical binding]; other site 233413007736 Low-spin heme (heme b) binding site [chemical binding]; other site 233413007737 Putative water exit pathway; other site 233413007738 Binuclear center (heme o3/CuB) [ion binding]; other site 233413007739 K-pathway; other site 233413007740 Putative proton exit pathway; other site 233413007741 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 233413007742 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 233413007743 siderophore binding site; other site 233413007744 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 233413007745 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 233413007746 putative NAD(P) binding site [chemical binding]; other site 233413007747 putative substrate binding site [chemical binding]; other site 233413007748 catalytic Zn binding site [ion binding]; other site 233413007749 structural Zn binding site [ion binding]; other site 233413007750 dimer interface [polypeptide binding]; other site 233413007751 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 233413007752 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 233413007753 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 233413007754 dimer interface [polypeptide binding]; other site 233413007755 putative radical transfer pathway; other site 233413007756 diiron center [ion binding]; other site 233413007757 tyrosyl radical; other site 233413007758 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 233413007759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007760 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 233413007761 Helix-turn-helix domains; Region: HTH; cl00088 233413007762 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 233413007763 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 233413007764 Class I ribonucleotide reductase; Region: RNR_I; cd01679 233413007765 active site 233413007766 dimer interface [polypeptide binding]; other site 233413007767 catalytic residues [active] 233413007768 effector binding site; other site 233413007769 R2 peptide binding site; other site 233413007770 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 233413007771 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 233413007772 catalytic residues [active] 233413007773 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 233413007774 DNA polymerase IV; Validated; Region: PRK03352 233413007775 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 233413007776 active site 233413007777 DNA binding site [nucleotide binding] 233413007778 short chain dehydrogenase; Provisional; Region: PRK05650 233413007779 classical (c) SDRs; Region: SDR_c; cd05233 233413007780 NAD(P) binding site [chemical binding]; other site 233413007781 active site 233413007782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413007783 Helix-turn-helix domains; Region: HTH; cl00088 233413007784 Cytochrome P450; Region: p450; cl12078 233413007785 Transcriptional regulators [Transcription]; Region: FadR; COG2186 233413007786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 233413007787 DNA-binding site [nucleotide binding]; DNA binding site 233413007788 FCD domain; Region: FCD; cl11656 233413007789 Transcriptional regulators [Transcription]; Region: FadR; COG2186 233413007790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 233413007791 DNA-binding site [nucleotide binding]; DNA binding site 233413007792 FCD domain; Region: FCD; cl11656 233413007793 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413007794 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413007795 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413007796 active site 233413007797 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413007798 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 233413007799 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 233413007800 active site 233413007801 DNA binding site [nucleotide binding] 233413007802 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 233413007803 DNA binding site [nucleotide binding] 233413007804 Carbon starvation protein CstA; Region: CstA; cl00856 233413007805 DoxX; Region: DoxX; cl00976 233413007806 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 233413007807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 233413007808 Helix-turn-helix domains; Region: HTH; cl00088 233413007809 Protein of unknown function (DUF732); Region: DUF732; pfam05305 233413007810 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 233413007811 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 233413007812 active site 233413007813 substrate binding site [chemical binding]; other site 233413007814 metal binding site [ion binding]; metal-binding site 233413007815 CrcB-like protein; Region: CRCB; cl09114 233413007816 CrcB-like protein; Region: CRCB; cl09114 233413007817 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 233413007818 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 233413007819 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 233413007820 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 233413007821 Protein of unknown function, DUF488; Region: DUF488; cl01246 233413007822 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413007823 active site 233413007824 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 233413007825 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 233413007826 putative hydrophobic ligand binding site [chemical binding]; other site 233413007827 protein interface [polypeptide binding]; other site 233413007828 gate; other site 233413007829 Sulfatase; Region: Sulfatase; cl10460 233413007830 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 233413007831 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 233413007832 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 233413007833 Catalytic domain of Protein Kinases; Region: PKc; cd00180 233413007834 active site 233413007835 ATP binding site [chemical binding]; other site 233413007836 substrate binding site [chemical binding]; other site 233413007837 activation loop (A-loop); other site 233413007838 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 233413007839 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl02058 233413007840 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 233413007841 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 233413007842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 233413007843 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 233413007844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007845 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 233413007846 short chain dehydrogenase; Provisional; Region: PRK06181 233413007847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413007848 NAD(P) binding site [chemical binding]; other site 233413007849 active site 233413007850 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 233413007851 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 233413007852 NAD binding site [chemical binding]; other site 233413007853 catalytic Zn binding site [ion binding]; other site 233413007854 substrate binding site [chemical binding]; other site 233413007855 structural Zn binding site [ion binding]; other site 233413007856 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413007857 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413007858 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413007859 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413007860 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 233413007861 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 233413007862 AMP-binding enzyme; Region: AMP-binding; cl15778 233413007863 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 233413007864 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 233413007865 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 233413007866 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 233413007867 Protein of unknown function (DUF808); Region: DUF808; cl01002 233413007868 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 233413007869 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 233413007870 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413007871 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413007872 active site 233413007873 Helix-turn-helix domains; Region: HTH; cl00088 233413007874 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 233413007875 PE family; Region: PE; pfam00934 233413007876 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 233413007877 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413007878 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 233413007879 DinB superfamily; Region: DinB_2; cl00986 233413007880 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 233413007881 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 233413007882 SmpB-tmRNA interface; other site 233413007883 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 233413007884 FtsX-like permease family; Region: FtsX; pfam02687 233413007885 Type II (General) Secretory Pathway (IISP) Family protein; Region: 3a0501s02; TIGR00960 233413007886 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413007887 Walker A/P-loop; other site 233413007888 ATP binding site [chemical binding]; other site 233413007889 Q-loop/lid; other site 233413007890 ABC transporter signature motif; other site 233413007891 Walker B; other site 233413007892 D-loop; other site 233413007893 H-loop/switch region; other site 233413007894 Mechanosensitive ion channel; Region: MS_channel; pfam00924 233413007895 peptide chain release factor 2; Validated; Region: prfB; PRK00578 233413007896 RF-1 domain; Region: RF-1; cl02875 233413007897 RF-1 domain; Region: RF-1; cl02875 233413007898 ferredoxin-NADP+ reductase; Region: PLN02852 233413007899 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 233413007900 FAD binding domain; Region: FAD_binding_4; pfam01565 233413007901 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 233413007902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413007903 FeS/SAM binding site; other site 233413007904 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 233413007905 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 233413007906 aromatic arch; other site 233413007907 DCoH dimer interaction site [polypeptide binding]; other site 233413007908 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 233413007909 DCoH tetramer interaction site [polypeptide binding]; other site 233413007910 substrate binding site [chemical binding]; other site 233413007911 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 233413007912 trimer interface [polypeptide binding]; other site 233413007913 dimer interface [polypeptide binding]; other site 233413007914 putative active site [active] 233413007915 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 233413007916 MoaE interaction surface [polypeptide binding]; other site 233413007917 MoeB interaction surface [polypeptide binding]; other site 233413007918 thiocarboxylated glycine; other site 233413007919 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 233413007920 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413007921 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 233413007922 nucleoside/Zn binding site; other site 233413007923 dimer interface [polypeptide binding]; other site 233413007924 catalytic motif [active] 233413007925 Transposase, Mutator family; Region: Transposase_mut; pfam00872 233413007926 MULE transposase domain; Region: MULE; pfam10551 233413007927 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 233413007928 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 233413007929 ATP binding site [chemical binding]; other site 233413007930 substrate interface [chemical binding]; other site 233413007931 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 233413007932 active site residue [active] 233413007933 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 233413007934 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 233413007935 active site residue [active] 233413007936 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 233413007937 active site residue [active] 233413007938 Cytochrome P450; Region: p450; cl12078 233413007939 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 233413007940 Helix-turn-helix domains; Region: HTH; cl00088 233413007941 DNA binding site [nucleotide binding] 233413007942 PPE family; Region: PPE; pfam00823 233413007943 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 233413007944 hypothetical protein; Provisional; Region: PRK07877 233413007945 FMN binding site [chemical binding]; other site 233413007946 dimer interface [polypeptide binding]; other site 233413007947 Integrase core domain; Region: rve; cl01316 233413007948 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 233413007949 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413007950 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413007951 hypothetical protein; Provisional; Region: PRK07877 233413007952 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 233413007953 dimer interface [polypeptide binding]; other site 233413007954 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 233413007955 GAF domain; Region: GAF; cl00853 233413007956 Histidine kinase; Region: HisKA_3; pfam07730 233413007957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 233413007958 ATP binding site [chemical binding]; other site 233413007959 Mg2+ binding site [ion binding]; other site 233413007960 G-X-G motif; other site 233413007961 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 233413007962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 233413007963 active site 233413007964 phosphorylation site [posttranslational modification] 233413007965 intermolecular recognition site; other site 233413007966 dimerization interface [polypeptide binding]; other site 233413007967 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 233413007968 DNA binding residues [nucleotide binding] 233413007969 dimerization interface [polypeptide binding]; other site 233413007970 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 233413007971 Ligand Binding Site [chemical binding]; other site 233413007972 PPE family; Region: PPE; pfam00823 233413007973 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413007974 PPE family; Region: PPE; pfam00823 233413007975 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413007976 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 233413007977 active site 233413007978 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 233413007979 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413007980 FeS/SAM binding site; other site 233413007981 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413007982 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413007983 active site 233413007984 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413007985 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413007986 active site 233413007987 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 233413007988 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 233413007989 NAD(P) binding site [chemical binding]; other site 233413007990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 233413007991 active site 233413007992 phosphorylation site [posttranslational modification] 233413007993 intermolecular recognition site; other site 233413007994 dimerization interface [polypeptide binding]; other site 233413007995 PPE family; Region: PPE; pfam00823 233413007996 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 233413007997 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 233413007998 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 233413007999 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 233413008000 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 233413008001 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 233413008002 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 233413008003 putative dimer interface [polypeptide binding]; other site 233413008004 [2Fe-2S] cluster binding site [ion binding]; other site 233413008005 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 233413008006 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 233413008007 SLBB domain; Region: SLBB; pfam10531 233413008008 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 233413008009 NADH dehydrogenase subunit G; Validated; Region: PRK07860 233413008010 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 233413008011 catalytic loop [active] 233413008012 iron binding site [ion binding]; other site 233413008013 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 233413008014 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 233413008015 [4Fe-4S] binding site [ion binding]; other site 233413008016 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 233413008017 NADH dehydrogenase; Region: NADHdh; cl00469 233413008018 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 233413008019 4Fe-4S binding domain; Region: Fer4; cl02805 233413008020 4Fe-4S binding domain; Region: Fer4; cl02805 233413008021 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 233413008022 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 233413008023 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 233413008024 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 233413008025 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 233413008026 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 233413008027 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 233413008028 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 233413008029 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 233413008030 PPE family; Region: PPE; pfam00823 233413008031 PPE family; Region: PPE; pfam00823 233413008032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413008033 Helix-turn-helix domains; Region: HTH; cl00088 233413008034 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 233413008035 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 233413008036 [2Fe-2S] cluster binding site [ion binding]; other site 233413008037 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 233413008038 putative alpha subunit interface [polypeptide binding]; other site 233413008039 putative active site [active] 233413008040 putative substrate binding site [chemical binding]; other site 233413008041 Fe binding site [ion binding]; other site 233413008042 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 233413008043 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 233413008044 MoxR-like ATPases [General function prediction only]; Region: COG0714 233413008045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413008046 Walker A motif; other site 233413008047 ATP binding site [chemical binding]; other site 233413008048 Walker B motif; other site 233413008049 arginine finger; other site 233413008050 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 233413008051 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413008052 Helix-turn-helix domains; Region: HTH; cl00088 233413008053 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 233413008054 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 233413008055 putative active site [active] 233413008056 putative substrate binding site [chemical binding]; other site 233413008057 ATP binding site [chemical binding]; other site 233413008058 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 233413008059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413008060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413008061 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413008062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413008063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413008064 Helix-turn-helix domains; Region: HTH; cl00088 233413008065 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 233413008066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413008067 NAD(P) binding site [chemical binding]; other site 233413008068 active site 233413008069 amidase; Provisional; Region: PRK06170 233413008070 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 233413008071 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413008072 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413008073 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413008074 Domain of unknown function (DUF385); Region: DUF385; cl04387 233413008075 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 233413008076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413008077 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413008078 putative active site [active] 233413008079 Phd_YefM; Region: PhdYeFM; cl09153 233413008080 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 233413008081 Helix-turn-helix domains; Region: HTH; cl00088 233413008082 RES domain; Region: RES; cl02411 233413008083 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 233413008084 Helix-turn-helix domains; Region: HTH; cl00088 233413008085 Integrase core domain; Region: rve; cl01316 233413008086 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 233413008087 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 233413008088 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 233413008089 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 233413008090 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 233413008091 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 233413008092 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 233413008093 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 233413008094 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 233413008095 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 233413008096 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 233413008097 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 233413008098 active site 233413008099 ATP binding site [chemical binding]; other site 233413008100 Transcription factor WhiB; Region: Whib; pfam02467 233413008101 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 233413008102 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413008103 HRDC domain; Region: HRDC; cl02578 233413008104 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 233413008105 catalytic residues [active] 233413008106 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 233413008107 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 233413008108 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 233413008109 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 233413008110 putative NADH binding site [chemical binding]; other site 233413008111 putative active site [active] 233413008112 nudix motif; other site 233413008113 putative metal binding site [ion binding]; other site 233413008114 Ion channel; Region: Ion_trans_2; cl11596 233413008115 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 233413008116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413008117 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413008118 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 233413008119 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 233413008120 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413008121 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 233413008122 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 233413008123 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413008124 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 233413008125 nucleophilic elbow; other site 233413008126 catalytic triad; other site 233413008127 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 233413008128 active site 233413008129 DNA binding site [nucleotide binding] 233413008130 TIGR02569 family protein; Region: TIGR02569_actnb 233413008131 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 233413008132 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 233413008133 ATP binding site [chemical binding]; other site 233413008134 substrate interface [chemical binding]; other site 233413008135 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 233413008136 active site residue [active] 233413008137 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 233413008138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413008139 Helix-turn-helix domains; Region: HTH; cl00088 233413008140 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 233413008141 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 233413008142 dinuclear metal binding motif [ion binding]; other site 233413008143 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 233413008144 DEAD-like helicases superfamily; Region: DEXDc; smart00487 233413008145 ATP binding site [chemical binding]; other site 233413008146 Mg++ binding site [ion binding]; other site 233413008147 motif III; other site 233413008148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 233413008149 nucleotide binding region [chemical binding]; other site 233413008150 ATP-binding site [chemical binding]; other site 233413008151 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 233413008152 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 233413008153 P-loop; other site 233413008154 Magnesium ion binding site [ion binding]; other site 233413008155 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 233413008156 Magnesium ion binding site [ion binding]; other site 233413008157 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 233413008158 catalytic core [active] 233413008159 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 233413008160 chorismate binding enzyme; Region: Chorismate_bind; cl10555 233413008161 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 233413008162 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 233413008163 Transcription factor WhiB; Region: Whib; pfam02467 233413008164 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 233413008165 PAS domain S-box; Region: sensory_box; TIGR00229 233413008166 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 233413008167 Histidine kinase; Region: HisKA_2; cl06527 233413008168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 233413008169 ATP binding site [chemical binding]; other site 233413008170 Mg2+ binding site [ion binding]; other site 233413008171 G-X-G motif; other site 233413008172 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 233413008173 carboxyltransferase (CT) interaction site; other site 233413008174 biotinylation site [posttranslational modification]; other site 233413008175 Putative zinc-finger; Region: zf-HC2; cl15806 233413008176 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 233413008177 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 233413008178 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 233413008179 DNA binding residues [nucleotide binding] 233413008180 short chain dehydrogenase; Provisional; Region: PRK08278 233413008181 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 233413008182 NAD(P) binding site [chemical binding]; other site 233413008183 homodimer interface [polypeptide binding]; other site 233413008184 active site 233413008185 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 233413008186 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 233413008187 putative deacylase active site [active] 233413008188 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 233413008189 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 233413008190 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 233413008191 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 233413008192 putative active site [active] 233413008193 putative substrate binding site [chemical binding]; other site 233413008194 ATP binding site [chemical binding]; other site 233413008195 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 233413008196 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 233413008197 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 233413008198 hinge; other site 233413008199 active site 233413008200 Predicted GTPases [General function prediction only]; Region: COG1162 233413008201 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 233413008202 GTPase/Zn-binding domain interface [polypeptide binding]; other site 233413008203 GTP/Mg2+ binding site [chemical binding]; other site 233413008204 G4 box; other site 233413008205 G5 box; other site 233413008206 G1 box; other site 233413008207 Switch I region; other site 233413008208 G2 box; other site 233413008209 G3 box; other site 233413008210 Switch II region; other site 233413008211 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 233413008212 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 233413008213 putative di-iron ligands [ion binding]; other site 233413008214 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 233413008215 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 233413008216 FAD binding pocket [chemical binding]; other site 233413008217 FAD binding motif [chemical binding]; other site 233413008218 phosphate binding motif [ion binding]; other site 233413008219 beta-alpha-beta structure motif; other site 233413008220 NAD binding pocket [chemical binding]; other site 233413008221 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 233413008222 catalytic loop [active] 233413008223 iron binding site [ion binding]; other site 233413008224 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 233413008225 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413008226 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413008227 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 233413008228 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 233413008229 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 233413008230 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 233413008231 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 233413008232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413008233 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 233413008234 putative substrate translocation pore; other site 233413008235 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 233413008236 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 233413008237 ligand binding site [chemical binding]; other site 233413008238 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 233413008239 nucleophile elbow; other site 233413008240 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 233413008241 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413008242 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 233413008243 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 233413008244 30S subunit binding site; other site 233413008245 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 233413008246 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 233413008247 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 233413008248 lipoprotein LpqB; Provisional; Region: PRK13616 233413008249 Sporulation and spore germination; Region: Germane; cl11253 233413008250 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 233413008251 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 233413008252 dimerization interface [polypeptide binding]; other site 233413008253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 233413008254 dimer interface [polypeptide binding]; other site 233413008255 phosphorylation site [posttranslational modification] 233413008256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 233413008257 ATP binding site [chemical binding]; other site 233413008258 Mg2+ binding site [ion binding]; other site 233413008259 G-X-G motif; other site 233413008260 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 233413008261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 233413008262 active site 233413008263 phosphorylation site [posttranslational modification] 233413008264 intermolecular recognition site; other site 233413008265 dimerization interface [polypeptide binding]; other site 233413008266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 233413008267 DNA binding site [nucleotide binding] 233413008268 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 233413008269 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 233413008270 TMP-binding site; other site 233413008271 ATP-binding site [chemical binding]; other site 233413008272 Adenosylhomocysteinase; Provisional; Region: PTZ00075 233413008273 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 233413008274 oligomerization interface [polypeptide binding]; other site 233413008275 active site 233413008276 NAD+ binding site [chemical binding]; other site 233413008277 Helix-turn-helix domains; Region: HTH; cl00088 233413008278 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 233413008279 Rubredoxin [Energy production and conversion]; Region: COG1773 233413008280 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 233413008281 iron binding site [ion binding]; other site 233413008282 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 233413008283 Rubredoxin; Region: Rubredoxin; pfam00301 233413008284 iron binding site [ion binding]; other site 233413008285 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 233413008286 Di-iron ligands [ion binding]; other site 233413008287 amino acid transporter; Region: 2A0306; TIGR00909 233413008288 Spore germination protein; Region: Spore_permease; cl15802 233413008289 Spore germination protein; Region: Spore_permease; cl15802 233413008290 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 233413008291 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 233413008292 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 233413008293 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 233413008294 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 233413008295 active site 233413008296 substrate binding site [chemical binding]; other site 233413008297 metal binding site [ion binding]; metal-binding site 233413008298 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 233413008299 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 233413008300 Transcription factor WhiB; Region: Whib; pfam02467 233413008301 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 233413008302 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 233413008303 phosphate binding site [ion binding]; other site 233413008304 dimer interface [polypeptide binding]; other site 233413008305 substrate binding site [chemical binding]; other site 233413008306 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 233413008307 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 233413008308 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 233413008309 putative FMN binding site [chemical binding]; other site 233413008310 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 233413008311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413008312 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 233413008313 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 233413008314 active site 233413008315 Substrate binding site; other site 233413008316 Mg++ binding site; other site 233413008317 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 233413008318 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 233413008319 Probable Catalytic site; other site 233413008320 metal-binding site 233413008321 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 233413008322 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 233413008323 NADP binding site [chemical binding]; other site 233413008324 active site 233413008325 putative substrate binding site [chemical binding]; other site 233413008326 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 233413008327 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413008328 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 233413008329 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 233413008330 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 233413008331 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413008332 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 233413008333 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 233413008334 CoA-transferase family III; Region: CoA_transf_3; pfam02515 233413008335 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 233413008336 Permease family; Region: Xan_ur_permease; cl00967 233413008337 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 233413008338 active site clefts [active] 233413008339 zinc binding site [ion binding]; other site 233413008340 dimer interface [polypeptide binding]; other site 233413008341 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413008342 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 233413008343 FAD binding site [chemical binding]; other site 233413008344 homotetramer interface [polypeptide binding]; other site 233413008345 substrate binding pocket [chemical binding]; other site 233413008346 catalytic base [active] 233413008347 AIR carboxylase; Region: AIRC; cl00310 233413008348 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 233413008349 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 233413008350 GtrA-like protein; Region: GtrA; cl00971 233413008351 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 233413008352 Bacterial membrane flanked domain; Region: DUF304; cl01348 233413008353 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 233413008354 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 233413008355 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 233413008356 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 233413008357 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 233413008358 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 233413008359 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 233413008360 Maf-like protein; Region: Maf; pfam02545 233413008361 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 233413008362 active site 233413008363 dimer interface [polypeptide binding]; other site 233413008364 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 233413008365 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 233413008366 active site residue [active] 233413008367 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 233413008368 active site residue [active] 233413008369 Fe-S metabolism associated domain; Region: SufE; cl00951 233413008370 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 233413008371 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 233413008372 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 233413008373 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 233413008374 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 233413008375 carboxyltransferase (CT) interaction site; other site 233413008376 biotinylation site [posttranslational modification]; other site 233413008377 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 233413008378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 233413008379 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 233413008380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 233413008381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 233413008382 L-lysine aminotransferase; Provisional; Region: PRK08297 233413008383 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 233413008384 inhibitor-cofactor binding pocket; inhibition site 233413008385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413008386 catalytic residue [active] 233413008387 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 233413008388 Helix-turn-helix domains; Region: HTH; cl00088 233413008389 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 233413008390 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 233413008391 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 233413008392 tetrameric interface [polypeptide binding]; other site 233413008393 NAD binding site [chemical binding]; other site 233413008394 catalytic residues [active] 233413008395 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 233413008396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413008397 Helix-turn-helix domains; Region: HTH; cl00088 233413008398 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 233413008399 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 233413008400 ATP binding site [chemical binding]; other site 233413008401 putative Mg++ binding site [ion binding]; other site 233413008402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 233413008403 nucleotide binding region [chemical binding]; other site 233413008404 ATP-binding site [chemical binding]; other site 233413008405 DEAD/H associated; Region: DEAD_assoc; pfam08494 233413008406 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 233413008407 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 233413008408 putative DNA binding site [nucleotide binding]; other site 233413008409 catalytic residue [active] 233413008410 putative H2TH interface [polypeptide binding]; other site 233413008411 putative catalytic residues [active] 233413008412 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 233413008413 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 233413008414 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413008415 Sulfatase; Region: Sulfatase; cl10460 233413008416 PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558 233413008417 probable active site [active] 233413008418 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 233413008419 PhoU domain; Region: PhoU; pfam01895 233413008420 PhoU domain; Region: PhoU; pfam01895 233413008421 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 233413008422 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 233413008423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413008424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413008425 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 233413008426 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 233413008427 putative active site pocket [active] 233413008428 dimerization interface [polypeptide binding]; other site 233413008429 putative catalytic residue [active] 233413008430 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 233413008431 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 233413008432 metal binding site [ion binding]; metal-binding site 233413008433 putative dimer interface [polypeptide binding]; other site 233413008434 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 233413008435 amidohydrolase; Region: amidohydrolases; TIGR01891 233413008436 metal binding site [ion binding]; metal-binding site 233413008437 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 233413008438 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 233413008439 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 233413008440 active site 233413008441 substrate binding site [chemical binding]; other site 233413008442 metal binding site [ion binding]; metal-binding site 233413008443 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 233413008444 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 233413008445 Phosphoesterase family; Region: Phosphoesterase; cl15450 233413008446 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413008447 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 233413008448 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 233413008449 active site 233413008450 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 233413008451 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 233413008452 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 233413008453 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 233413008454 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 233413008455 active site 233413008456 catalytic motif [active] 233413008457 Zn binding site [ion binding]; other site 233413008458 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 233413008459 putative Iron-sulfur protein interface [polypeptide binding]; other site 233413008460 putative proximal heme binding site [chemical binding]; other site 233413008461 putative SdhD-like interface [polypeptide binding]; other site 233413008462 putative distal heme binding site [chemical binding]; other site 233413008463 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 233413008464 putative Iron-sulfur protein interface [polypeptide binding]; other site 233413008465 putative proximal heme binding site [chemical binding]; other site 233413008466 putative SdhC-like subunit interface [polypeptide binding]; other site 233413008467 putative distal heme binding site [chemical binding]; other site 233413008468 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 233413008469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413008470 domain; Region: Succ_DH_flav_C; pfam02910 233413008471 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 233413008472 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413008473 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 233413008474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413008475 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 233413008476 MoaE interaction surface [polypeptide binding]; other site 233413008477 MoeB interaction surface [polypeptide binding]; other site 233413008478 thiocarboxylated glycine; other site 233413008479 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 233413008480 MoaE homodimer interface [polypeptide binding]; other site 233413008481 MoaD interaction [polypeptide binding]; other site 233413008482 active site residues [active] 233413008483 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 233413008484 trimer interface [polypeptide binding]; other site 233413008485 dimer interface [polypeptide binding]; other site 233413008486 putative active site [active] 233413008487 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 233413008488 aromatic arch; other site 233413008489 DCoH dimer interaction site [polypeptide binding]; other site 233413008490 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 233413008491 DCoH tetramer interaction site [polypeptide binding]; other site 233413008492 substrate binding site [chemical binding]; other site 233413008493 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 233413008494 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413008495 FeS/SAM binding site; other site 233413008496 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 233413008497 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 233413008498 Helix-turn-helix domains; Region: HTH; cl00088 233413008499 DNA binding site [nucleotide binding] 233413008500 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 233413008501 phosphopeptide binding site; other site 233413008502 Condensation domain; Region: Condensation; pfam00668 233413008503 Transposase; Region: DEDD_Tnp_IS110; pfam01548 233413008504 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 233413008505 Uncharacterized conserved protein [Function unknown]; Region: COG2128 233413008506 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 233413008507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 233413008508 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 233413008509 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 233413008510 hypothetical protein; Provisional; Region: PRK06541 233413008511 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 233413008512 inhibitor-cofactor binding pocket; inhibition site 233413008513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413008514 catalytic residue [active] 233413008515 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 233413008516 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 233413008517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413008518 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 233413008519 active site 233413008520 dimer interface [polypeptide binding]; other site 233413008521 Protein of unknown function (DUF732); Region: DUF732; pfam05305 233413008522 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 233413008523 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 233413008524 DNA binding residues [nucleotide binding] 233413008525 dimer interface [polypeptide binding]; other site 233413008526 metal binding site [ion binding]; metal-binding site 233413008527 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 233413008528 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 233413008529 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 233413008530 active site 233413008531 HIGH motif; other site 233413008532 dimer interface [polypeptide binding]; other site 233413008533 KMSKS motif; other site 233413008534 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413008535 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 233413008536 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 233413008537 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 233413008538 homodimer interface [polypeptide binding]; other site 233413008539 substrate-cofactor binding pocket; other site 233413008540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413008541 catalytic residue [active] 233413008542 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 233413008543 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 233413008544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413008545 S-adenosylmethionine binding site [chemical binding]; other site 233413008546 PPE family; Region: PPE; pfam00823 233413008547 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413008548 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413008549 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413008550 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413008551 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413008552 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413008553 Mb3376c, PE_PGRS50b, len: 1337 aa. Equivalent to middle part of Rv3345c (PE_PGRS50) and Rv3344c (PE_PGRS49), len: 1538 aa and 484 aa, from Mycobacterium tuberculosis strain H37Rv, (81.45% identity in 992 aa overlap and 100.000% identity in 477 aa overlap). Rv3345c: Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to AAK47791 from strain CDC1551 but with some big gaps (after residues 501 and 1419; and for AAK47791 after residue 991). Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 4508, E(): 7e-161, (52.1% identity in 1529 aa overlap); MTV004_1, MTV023_21, MTV023_15, MTCY493_4, MTV039_16, MTV008_46, MTV023_14, MTV023_19, MTV043_26, MTCY493_2, MTCY441_4; etc. Rv3344c: Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-, ala-rich proteins. Appears to be a gene fragment, should be in-frame with following ORF, MTV016.45c, frameshift required around 49595 but could not be found on checking BAC and cosmid clones. Similar to many from M. tuberculosis strains H37Rv and CDC1551 e.g. O53557|Rv3512|MTV023.19 (1079 aa), FASTA scores: opt: 1595, E(): 1.8e-54, (52.0% identity in 544 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS50 exists as a single gene. In Mycobacterium bovis, a single base deletion (g-*) splits PE_PGRS50 into 2 parts, PE_PGRS50a and PE_PGRS50b. Also in Mycobacterium tuberculosis strain H37Rv, PE_PGRS49 and PE_PGRS50 exist as 2 genes. In Mycobacterium bovis, a single base deletion (c-*) leads to PE_PGRS49 and PE_PGRS50b existing as a single product.;PE-PGRS FAMILY PROTEIN [SECOND PART] 233413008554 PE family; Region: PE; pfam00934 233413008555 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 233413008556 Mb3379c, PPE55b, len: 1061 aa. Equivalent to 3' end of Rv3347c, len: 3157 aa, from Mycobacterium tuberculosis strain H37Rv, (99.812% identity in 1061 aa overlap). Member of the Mycobacterium tuberculosis PPE family, Gly-, Ala-, Asn-rich protein. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551, e.g. O50379|Rv3350c|MTV004.07c (3716 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); and other upstream ORFs MTV004_5, MTY13E10_15, MTCY28_16, MTCY63_9, MTY13E10_17, MTCY180_1; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE55 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits PPE55 into 2 parts, PPE55a and PPE55b.;PPE FAMILY PROTEIN [SECOND PART] 233413008557 PPE family; Region: PPE; pfam00823 233413008558 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413008559 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413008560 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413008561 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413008562 Transposase; Region: DEDD_Tnp_IS110; pfam01548 233413008563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 233413008564 Transposase; Region: DDE_Tnp_ISL3; pfam01610 233413008565 Mb3383c, PPE56d, len: 1219 aa. Equivalent to 3' end of Rv3350c, len: 3716 aa, from Mycobacterium tuberculosis strain H37Rv, (100.000% identity in 1219 aa overlap). Member of the Mycobacterium tuberculosis PPE family of Gly-, Ala-, Asn-rich proteins, similar to many Mycobacterium tuberculosis proteins from strains H37Rv and CDC1551, e.g. O50378|Rv3347c|MTV004.03c (3157 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); MTCY28_16, MTV050_2, MTY13E10_17, MTCY63_10, MTCY180_1, MTCY63_9, MTV050_1, MTV014_3, MTY13E10_15; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis, 2 frameshifts due to single base transversion (c-a) and a single base deletion (g-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d.;PPE FAMILY PROTEIN [THIRD PART] 233413008566 Mb3384c, PPE56b, len: 2044 aa. Equivalent to middle part of Rv3350c, len: 3716 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 2018 aa overlap). Member of the Mycobacterium tuberculosis PPE family of Gly-, Ala-, Asn-rich proteins, similar to many M. tuberculosis proteins from strains H37Rv and CDC1551, e.g. O50378|Rv3347c|MTV004.03c (3157 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); MTCY28_16, MTV050_2, MTY13E10_17, MTCY63_10, MTCY180_1, MTCY63_9, MTV050_1, MTV014_3, MTY13E10_15; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis, 2 frameshifts due to single base transversion (c-a) and a single base deletion (g-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d.;PPE FAMILY PROTEIN [SECOND PART] 233413008567 PPE family; Region: PPE; pfam00823 233413008568 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413008569 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413008570 Berberine and berberine like; Region: BBE; pfam08031 233413008571 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 233413008572 Protein of unknown function (DUF732); Region: DUF732; pfam05305 233413008573 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 233413008574 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 233413008575 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 233413008576 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 233413008577 homodimer interface [polypeptide binding]; other site 233413008578 NADP binding site [chemical binding]; other site 233413008579 substrate binding site [chemical binding]; other site 233413008580 Phd_YefM; Region: PhdYeFM; cl09153 233413008581 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 233413008582 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 233413008583 active site 233413008584 FMN binding site [chemical binding]; other site 233413008585 substrate binding site [chemical binding]; other site 233413008586 putative catalytic residue [active] 233413008587 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 233413008588 phosphate binding site [ion binding]; other site 233413008589 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 233413008590 phosphopeptide binding site; other site 233413008591 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 233413008592 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 233413008593 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 233413008594 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 233413008595 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cd00882 233413008596 G1 box; other site 233413008597 GTP/Mg2+ binding site [chemical binding]; other site 233413008598 G2 box; other site 233413008599 Switch I region; other site 233413008600 G3 box; other site 233413008601 Switch II region; other site 233413008602 G4 box; other site 233413008603 G5 box; other site 233413008604 Protein of unknown function (DUF742); Region: DUF742; pfam05331 233413008605 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 233413008606 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 233413008607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 233413008608 ATP binding site [chemical binding]; other site 233413008609 Mg2+ binding site [ion binding]; other site 233413008610 G-X-G motif; other site 233413008611 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 233413008612 PE family; Region: PE; pfam00934 233413008613 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 233413008614 FMN binding site [chemical binding]; other site 233413008615 dimer interface [polypeptide binding]; other site 233413008616 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 233413008617 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 233413008618 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 233413008619 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 233413008620 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 233413008621 generic binding surface II; other site 233413008622 generic binding surface I; other site 233413008623 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413008624 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413008625 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413008626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 233413008627 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 233413008628 active site 233413008629 motif I; other site 233413008630 motif II; other site 233413008631 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 233413008632 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413008633 substrate binding site [chemical binding]; other site 233413008634 oxyanion hole (OAH) forming residues; other site 233413008635 trimer interface [polypeptide binding]; other site 233413008636 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 233413008637 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 233413008638 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 233413008639 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 233413008640 motif II; other site 233413008641 ent-copalyl diphosphate synthase; Region: PLN02592 233413008642 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 233413008643 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 233413008644 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 233413008645 TPP-binding site; other site 233413008646 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 233413008647 PYR/PP interface [polypeptide binding]; other site 233413008648 dimer interface [polypeptide binding]; other site 233413008649 TPP binding site [chemical binding]; other site 233413008650 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 233413008651 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 233413008652 LytB protein; Region: LYTB; cl00507 233413008653 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 233413008654 substrate binding pocket [chemical binding]; other site 233413008655 chain length determination region; other site 233413008656 substrate-Mg2+ binding site; other site 233413008657 catalytic residues [active] 233413008658 aspartate-rich region 1; other site 233413008659 active site lid residues [active] 233413008660 aspartate-rich region 2; other site 233413008661 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 233413008662 putative active site [active] 233413008663 Phd_YefM; Region: PhdYeFM; cl09153 233413008664 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 233413008665 Transposase domain (DUF772); Region: DUF772; cl12084 233413008666 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 233413008667 PE family; Region: PE; pfam00934 233413008668 enoyl-CoA hydratase; Region: PLN02864 233413008669 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 233413008670 dimer interaction site [polypeptide binding]; other site 233413008671 substrate-binding tunnel; other site 233413008672 active site 233413008673 catalytic site [active] 233413008674 substrate binding site [chemical binding]; other site 233413008675 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 233413008676 short chain dehydrogenase; Provisional; Region: PRK07201 233413008677 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 233413008678 putative NAD(P) binding site [chemical binding]; other site 233413008679 active site 233413008680 putative substrate binding site [chemical binding]; other site 233413008681 classical (c) SDRs; Region: SDR_c; cd05233 233413008682 NAD(P) binding site [chemical binding]; other site 233413008683 active site 233413008684 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 233413008685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413008686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413008687 S-adenosylmethionine binding site [chemical binding]; other site 233413008688 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 233413008689 active site 233413008690 DNA Polymerase Y-family; Region: PolY_like; cd03468 233413008691 DNA binding site [nucleotide binding] 233413008692 GMP synthase; Reviewed; Region: guaA; PRK00074 233413008693 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 233413008694 AMP/PPi binding site [chemical binding]; other site 233413008695 candidate oxyanion hole; other site 233413008696 catalytic triad [active] 233413008697 potential glutamine specificity residues [chemical binding]; other site 233413008698 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 233413008699 ATP Binding subdomain [chemical binding]; other site 233413008700 Ligand Binding sites [chemical binding]; other site 233413008701 Dimerization subdomain; other site 233413008702 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 233413008703 active site lid residues [active] 233413008704 substrate binding pocket [chemical binding]; other site 233413008705 catalytic residues [active] 233413008706 substrate-Mg2+ binding site; other site 233413008707 aspartate-rich region 1; other site 233413008708 aspartate-rich region 2; other site 233413008709 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 233413008710 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 233413008711 substrate binding pocket [chemical binding]; other site 233413008712 chain length determination region; other site 233413008713 substrate-Mg2+ binding site; other site 233413008714 catalytic residues [active] 233413008715 aspartate-rich region 1; other site 233413008716 active site lid residues [active] 233413008717 aspartate-rich region 2; other site 233413008718 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413008719 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413008720 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 233413008721 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 233413008722 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 233413008723 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 233413008724 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 233413008725 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 233413008726 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413008727 catalytic residue [active] 233413008728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 233413008729 hypothetical protein; Provisional; Region: PRK07579 233413008730 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 233413008731 active site 233413008732 cosubstrate binding site; other site 233413008733 substrate binding site [chemical binding]; other site 233413008734 catalytic site [active] 233413008735 Helix-turn-helix domains; Region: HTH; cl00088 233413008736 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 233413008737 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 233413008738 Phd_YefM; Region: PhdYeFM; cl09153 233413008739 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 233413008740 putative active site [active] 233413008741 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 233413008742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413008743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413008744 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 233413008745 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 233413008746 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 233413008747 phosphate binding site [ion binding]; other site 233413008748 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 233413008749 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 233413008750 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 233413008751 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 233413008752 active site 233413008753 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 233413008754 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 233413008755 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 233413008756 DNA binding residues [nucleotide binding] 233413008757 Transcription factor WhiB; Region: Whib; pfam02467 233413008758 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 233413008759 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 233413008760 ring oligomerisation interface [polypeptide binding]; other site 233413008761 ATP/Mg binding site [chemical binding]; other site 233413008762 stacking interactions; other site 233413008763 hinge regions; other site 233413008764 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 233413008765 oligomerisation interface [polypeptide binding]; other site 233413008766 mobile loop; other site 233413008767 roof hairpin; other site 233413008768 UGMP family protein; Validated; Region: PRK09604 233413008769 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 233413008770 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 233413008771 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 233413008772 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 233413008773 alanine racemase; Reviewed; Region: alr; PRK00053 233413008774 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 233413008775 active site 233413008776 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 233413008777 dimer interface [polypeptide binding]; other site 233413008778 substrate binding site [chemical binding]; other site 233413008779 catalytic residues [active] 233413008780 PPE family; Region: PPE; pfam00823 233413008781 putative transposase OrfB; Reviewed; Region: PHA02517 233413008782 Integrase core domain; Region: rve; cl01316 233413008783 Transposase, Mutator family; Region: Transposase_mut; pfam00872 233413008784 MULE transposase domain; Region: MULE; pfam10551 233413008785 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 233413008786 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 233413008787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413008788 catalytic residue [active] 233413008789 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 233413008790 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 233413008791 putative substrate binding site [chemical binding]; other site 233413008792 putative ATP binding site [chemical binding]; other site 233413008793 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 233413008794 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 233413008795 glutaminase active site [active] 233413008796 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 233413008797 dimer interface [polypeptide binding]; other site 233413008798 active site 233413008799 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 233413008800 dimer interface [polypeptide binding]; other site 233413008801 active site 233413008802 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 233413008803 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 233413008804 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 233413008805 active site 233413008806 substrate binding site [chemical binding]; other site 233413008807 metal binding site [ion binding]; metal-binding site 233413008808 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 233413008809 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 233413008810 23S rRNA interface [nucleotide binding]; other site 233413008811 L3 interface [polypeptide binding]; other site 233413008812 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413008813 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413008814 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 233413008815 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 233413008816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413008817 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 233413008818 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413008819 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413008820 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 233413008821 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 233413008822 active site 233413008823 catalytic residues [active] 233413008824 Protein of unknown function (DUF690); Region: DUF690; cl04939 233413008825 Cutinase; Region: Cutinase; cl15711 233413008826 Cutinase; Region: Cutinase; cl15711 233413008827 Sodium:solute symporter family; Region: SSF; cl00456 233413008828 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 233413008829 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 233413008830 dimerization interface 3.5A [polypeptide binding]; other site 233413008831 active site 233413008832 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 233413008833 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 233413008834 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 233413008835 alphaNTD - beta interaction site [polypeptide binding]; other site 233413008836 alphaNTD homodimer interface [polypeptide binding]; other site 233413008837 alphaNTD - beta' interaction site [polypeptide binding]; other site 233413008838 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 233413008839 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 233413008840 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 233413008841 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 233413008842 RNA binding surface [nucleotide binding]; other site 233413008843 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 233413008844 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 233413008845 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 233413008846 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 233413008847 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 233413008848 rRNA binding site [nucleotide binding]; other site 233413008849 predicted 30S ribosome binding site; other site 233413008850 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 233413008851 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 233413008852 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 233413008853 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 233413008854 NAD binding site [chemical binding]; other site 233413008855 substrate binding site [chemical binding]; other site 233413008856 homodimer interface [polypeptide binding]; other site 233413008857 active site 233413008858 Cupin domain; Region: Cupin_2; cl09118 233413008859 Domain of unknown function (DUF222); Region: DUF222; pfam02720 233413008860 Domain of unknown function DUF222; Region: DUF222; pfam02720 233413008861 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 233413008862 active site 233413008863 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 233413008864 extended (e) SDRs; Region: SDR_e; cd08946 233413008865 NAD(P) binding site [chemical binding]; other site 233413008866 active site 233413008867 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 233413008868 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 233413008869 active site 233413008870 catalytic residues [active] 233413008871 metal binding site [ion binding]; metal-binding site 233413008872 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 233413008873 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 233413008874 PYR/PP interface [polypeptide binding]; other site 233413008875 dimer interface [polypeptide binding]; other site 233413008876 TPP binding site [chemical binding]; other site 233413008877 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 233413008878 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 233413008879 TPP-binding site [chemical binding]; other site 233413008880 Cupin domain; Region: Cupin_2; cl09118 233413008881 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 233413008882 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413008883 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413008884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413008885 metabolite-proton symporter; Region: 2A0106; TIGR00883 233413008886 putative substrate translocation pore; other site 233413008887 PE family; Region: PE; pfam00934 233413008888 PPE family; Region: PPE; pfam00823 233413008889 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413008890 patatin-related protein; Region: TIGR03607 233413008891 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 233413008892 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 233413008893 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413008894 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413008895 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 233413008896 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413008897 LysE type translocator; Region: LysE; cl00565 233413008898 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 233413008899 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 233413008900 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 233413008901 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 233413008902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413008903 NAD(P) binding site [chemical binding]; other site 233413008904 active site 233413008905 DoxX; Region: DoxX; cl00976 233413008906 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 233413008907 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413008908 Helix-turn-helix domains; Region: HTH; cl00088 233413008909 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 233413008910 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 233413008911 active site 233413008912 homotetramer interface [polypeptide binding]; other site 233413008913 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413008914 mce related protein; Region: MCE; cl15431 233413008915 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413008916 mce related protein; Region: MCE; cl15431 233413008917 mce related protein; Region: MCE; cl15431 233413008918 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 233413008919 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413008920 mce related protein; Region: MCE; cl15431 233413008921 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413008922 mce related protein; Region: MCE; cl15431 233413008923 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 233413008924 mce related protein; Region: MCE; cl15431 233413008925 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 233413008926 Domain of unknown function DUF140; Region: DUF140; cl00510 233413008927 Domain of unknown function DUF140; Region: DUF140; cl00510 233413008928 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 233413008929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413008930 NAD(P) binding site [chemical binding]; other site 233413008931 active site 233413008932 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 233413008933 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 233413008934 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413008935 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 233413008936 FAD binding site [chemical binding]; other site 233413008937 substrate binding site [chemical binding]; other site 233413008938 catalytic base [active] 233413008939 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413008940 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413008941 active site 233413008942 acyl-CoA synthetase; Validated; Region: PRK07867 233413008943 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413008944 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413008945 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413008946 PE family; Region: PE; pfam00934 233413008947 PE family; Region: PE; pfam00934 233413008948 hypothetical protein; Validated; Region: PRK07586 233413008949 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 233413008950 PYR/PP interface [polypeptide binding]; other site 233413008951 dimer interface [polypeptide binding]; other site 233413008952 TPP binding site [chemical binding]; other site 233413008953 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 233413008954 TPP-binding site [chemical binding]; other site 233413008955 dimer interface [polypeptide binding]; other site 233413008956 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 233413008957 PE family; Region: PE; pfam00934 233413008958 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413008959 PE family; Region: PE; pfam00934 233413008960 acyl-CoA synthetase; Validated; Region: PRK07798 233413008961 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413008962 enoyl-CoA hydratase; Provisional; Region: PRK07799 233413008963 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413008964 substrate binding site [chemical binding]; other site 233413008965 oxyanion hole (OAH) forming residues; other site 233413008966 trimer interface [polypeptide binding]; other site 233413008967 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 233413008968 Cytochrome P450; Region: p450; cl12078 233413008969 Cytochrome P450; Region: p450; cl12078 233413008970 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 233413008971 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 233413008972 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 233413008973 DUF35 OB-fold domain; Region: DUF35; pfam01796 233413008974 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 233413008975 DUF35 OB-fold domain; Region: DUF35; pfam01796 233413008976 lipid-transfer protein; Provisional; Region: PRK07937 233413008977 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 233413008978 active site 233413008979 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 233413008980 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 233413008981 active site 233413008982 NHL repeat; Region: NHL; pfam01436 233413008983 NHL repeat; Region: NHL; pfam01436 233413008984 NHL repeat; Region: NHL; pfam01436 233413008985 NHL repeat; Region: NHL; pfam01436 233413008986 NHL repeat; Region: NHL; pfam01436 233413008987 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 233413008988 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 233413008989 trimer interface [polypeptide binding]; other site 233413008990 putative metal binding site [ion binding]; other site 233413008991 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 233413008992 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 233413008993 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 233413008994 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 233413008995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413008996 NAD(P) binding site [chemical binding]; other site 233413008997 active site 233413008998 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 233413008999 PPE family; Region: PPE; pfam00823 233413009000 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 233413009001 PPE family; Region: PPE; pfam00823 233413009002 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413009003 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413009004 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 233413009005 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 233413009006 active site 233413009007 catalytic residues [active] 233413009008 metal binding site [ion binding]; metal-binding site 233413009009 DmpG-like communication domain; Region: DmpG_comm; pfam07836 233413009010 acetaldehyde dehydrogenase; Validated; Region: PRK08300 233413009011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009012 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 233413009013 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 233413009014 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 233413009015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009016 enoyl-CoA hydratase; Region: PLN02864 233413009017 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 233413009018 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 233413009019 dimer interaction site [polypeptide binding]; other site 233413009020 substrate-binding tunnel; other site 233413009021 active site 233413009022 catalytic site [active] 233413009023 substrate binding site [chemical binding]; other site 233413009024 PPE family; Region: PPE; pfam00823 233413009025 Cutinase; Region: Cutinase; cl15711 233413009026 lipid-transfer protein; Provisional; Region: PRK07855 233413009027 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 233413009028 active site 233413009029 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 233413009030 putative active site [active] 233413009031 putative catalytic site [active] 233413009032 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 233413009033 active site 233413009034 catalytic site [active] 233413009035 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 233413009036 DUF35 OB-fold domain; Region: DUF35; pfam01796 233413009037 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413009038 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413009039 active site 233413009040 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413009041 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 233413009042 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413009043 active site 233413009044 Cytochrome P450; Region: p450; cl12078 233413009045 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 233413009046 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 233413009047 dimer interface [polypeptide binding]; other site 233413009048 active site 233413009049 Domain of unknown function (DUF385); Region: DUF385; cl04387 233413009050 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 233413009051 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 233413009052 homodimer interface [polypeptide binding]; other site 233413009053 NAD binding site [chemical binding]; other site 233413009054 active site 233413009055 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 233413009056 classical (c) SDRs; Region: SDR_c; cd05233 233413009057 NAD(P) binding site [chemical binding]; other site 233413009058 active site 233413009059 enoyl-CoA hydratase; Provisional; Region: PRK07938 233413009060 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413009061 substrate binding site [chemical binding]; other site 233413009062 oxyanion hole (OAH) forming residues; other site 233413009063 trimer interface [polypeptide binding]; other site 233413009064 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 233413009065 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 233413009066 Nitronate monooxygenase; Region: NMO; pfam03060 233413009067 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 233413009068 FMN binding site [chemical binding]; other site 233413009069 substrate binding site [chemical binding]; other site 233413009070 putative catalytic residue [active] 233413009071 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 233413009072 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 233413009073 putative di-iron ligands [ion binding]; other site 233413009074 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 233413009075 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 233413009076 FAD binding pocket [chemical binding]; other site 233413009077 FAD binding motif [chemical binding]; other site 233413009078 phosphate binding motif [ion binding]; other site 233413009079 beta-alpha-beta structure motif; other site 233413009080 NAD(p) ribose binding residues [chemical binding]; other site 233413009081 NAD binding pocket [chemical binding]; other site 233413009082 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 233413009083 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 233413009084 catalytic loop [active] 233413009085 iron binding site [ion binding]; other site 233413009086 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 233413009087 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 233413009088 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 233413009089 dimer interface [polypeptide binding]; other site 233413009090 active site 233413009091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413009092 Helix-turn-helix domains; Region: HTH; cl00088 233413009093 PPE family; Region: PPE; pfam00823 233413009094 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 233413009095 short chain dehydrogenase; Provisional; Region: PRK07831 233413009096 classical (c) SDRs; Region: SDR_c; cd05233 233413009097 NAD(P) binding site [chemical binding]; other site 233413009098 active site 233413009099 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 233413009100 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413009101 active site 233413009102 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 233413009103 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413009104 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413009105 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413009106 active site 233413009107 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 233413009108 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413009109 active site 233413009110 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 233413009111 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413009112 active site 233413009113 aspartate aminotransferase; Provisional; Region: PRK05764 233413009114 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 233413009115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413009116 homodimer interface [polypeptide binding]; other site 233413009117 catalytic residue [active] 233413009118 N-acetyltransferase; Region: Acetyltransf_2; cl00949 233413009119 Flavin Reductases; Region: FlaRed; cl00801 233413009120 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 233413009121 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 233413009122 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 233413009123 active site 233413009124 Fe binding site [ion binding]; other site 233413009125 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 233413009126 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 233413009127 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 233413009128 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 233413009129 Flavin binding site [chemical binding]; other site 233413009130 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 233413009131 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 233413009132 FAD binding pocket [chemical binding]; other site 233413009133 FAD binding motif [chemical binding]; other site 233413009134 phosphate binding motif [ion binding]; other site 233413009135 beta-alpha-beta structure motif; other site 233413009136 NAD(p) ribose binding residues [chemical binding]; other site 233413009137 NAD binding pocket [chemical binding]; other site 233413009138 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 233413009139 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 233413009140 catalytic loop [active] 233413009141 iron binding site [ion binding]; other site 233413009142 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413009143 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 233413009144 active site 233413009145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413009146 Helix-turn-helix domains; Region: HTH; cl00088 233413009147 Transcriptional regulators [Transcription]; Region: PurR; COG1609 233413009148 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 233413009149 DNA binding site [nucleotide binding] 233413009150 domain linker motif; other site 233413009151 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 233413009152 putative dimerization interface [polypeptide binding]; other site 233413009153 putative ligand binding site [chemical binding]; other site 233413009154 PknH-like extracellular domain; Region: PknH_C; pfam14032 233413009155 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413009156 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 233413009157 transmembrane helices; other site 233413009158 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 233413009159 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 233413009160 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 233413009161 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 233413009162 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 233413009163 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 233413009164 active site 233413009165 HIGH motif; other site 233413009166 nucleotide binding site [chemical binding]; other site 233413009167 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 233413009168 KMSKS motif; other site 233413009169 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 233413009170 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 233413009171 homotrimer interaction site [polypeptide binding]; other site 233413009172 zinc binding site [ion binding]; other site 233413009173 CDP-binding sites; other site 233413009174 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 233413009175 substrate binding site; other site 233413009176 dimer interface; other site 233413009177 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 233413009178 DNA repair protein RadA; Provisional; Region: PRK11823 233413009179 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 233413009180 Walker A motif/ATP binding site; other site 233413009181 ATP binding site [chemical binding]; other site 233413009182 Walker B motif; other site 233413009183 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 233413009184 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 233413009185 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 233413009186 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 233413009187 active site clefts [active] 233413009188 zinc binding site [ion binding]; other site 233413009189 dimer interface [polypeptide binding]; other site 233413009190 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 233413009191 endonuclease III; Region: ENDO3c; smart00478 233413009192 minor groove reading motif; other site 233413009193 helix-hairpin-helix signature motif; other site 233413009194 substrate binding pocket [chemical binding]; other site 233413009195 active site 233413009196 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 233413009197 PE family; Region: PE; pfam00934 233413009198 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413009199 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 233413009200 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 233413009201 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 233413009202 PE family; Region: PE; pfam00934 233413009203 Clp protease ATP binding subunit; Region: clpC; CHL00095 233413009204 Clp amino terminal domain; Region: Clp_N; pfam02861 233413009205 Clp amino terminal domain; Region: Clp_N; pfam02861 233413009206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413009207 Walker A motif; other site 233413009208 ATP binding site [chemical binding]; other site 233413009209 Walker B motif; other site 233413009210 arginine finger; other site 233413009211 UvrB/uvrC motif; Region: UVR; pfam02151 233413009212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413009213 Walker A motif; other site 233413009214 ATP binding site [chemical binding]; other site 233413009215 Walker B motif; other site 233413009216 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 233413009217 Lsr2; Region: Lsr2; pfam11774 233413009218 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 233413009219 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 233413009220 dimer interface [polypeptide binding]; other site 233413009221 putative anticodon binding site; other site 233413009222 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 233413009223 motif 1; other site 233413009224 dimer interface [polypeptide binding]; other site 233413009225 active site 233413009226 motif 2; other site 233413009227 motif 3; other site 233413009228 Type III pantothenate kinase; Region: Pan_kinase; cl09130 233413009229 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 233413009230 tetramerization interface [polypeptide binding]; other site 233413009231 active site 233413009232 Pantoate-beta-alanine ligase; Region: PanC; cd00560 233413009233 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 233413009234 active site 233413009235 ATP-binding site [chemical binding]; other site 233413009236 pantoate-binding site; other site 233413009237 HXXH motif; other site 233413009238 Uncharacterized conserved protein [Function unknown]; Region: COG5495 233413009239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009240 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 233413009241 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 233413009242 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 233413009243 catalytic center binding site [active] 233413009244 ATP binding site [chemical binding]; other site 233413009245 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 233413009246 homooctamer interface [polypeptide binding]; other site 233413009247 active site 233413009248 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 233413009249 dihydropteroate synthase; Region: DHPS; TIGR01496 233413009250 substrate binding pocket [chemical binding]; other site 233413009251 dimer interface [polypeptide binding]; other site 233413009252 inhibitor binding site; inhibition site 233413009253 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 233413009254 homodecamer interface [polypeptide binding]; other site 233413009255 GTP cyclohydrolase I; Provisional; Region: PLN03044 233413009256 active site 233413009257 putative catalytic site residues [active] 233413009258 zinc binding site [ion binding]; other site 233413009259 GTP-CH-I/GFRP interaction surface; other site 233413009260 FtsH Extracellular; Region: FtsH_ext; pfam06480 233413009261 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 233413009262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413009263 Walker A motif; other site 233413009264 ATP binding site [chemical binding]; other site 233413009265 Walker B motif; other site 233413009266 arginine finger; other site 233413009267 Peptidase family M41; Region: Peptidase_M41; pfam01434 233413009268 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 233413009269 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413009270 Protein of unknown function (DUF541); Region: SIMPL; cl01077 233413009271 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 233413009272 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 233413009273 Ligand Binding Site [chemical binding]; other site 233413009274 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 233413009275 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 233413009276 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 233413009277 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 233413009278 dimer interface [polypeptide binding]; other site 233413009279 substrate binding site [chemical binding]; other site 233413009280 metal binding sites [ion binding]; metal-binding site 233413009281 Integral membrane protein TerC family; Region: TerC; cl10468 233413009282 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 233413009283 Ligand binding site; other site 233413009284 Putative Catalytic site; other site 233413009285 DXD motif; other site 233413009286 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 233413009287 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 233413009288 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 233413009289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009290 NAD(P) binding site [chemical binding]; other site 233413009291 active site 233413009292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 233413009293 Helix-turn-helix domains; Region: HTH; cl00088 233413009294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 233413009295 transposase; Provisional; Region: PRK06526 233413009296 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413009297 Transposase, Mutator family; Region: Transposase_mut; pfam00872 233413009298 MULE transposase domain; Region: MULE; pfam10551 233413009299 Fic/DOC family; Region: Fic; cl00960 233413009300 DNA polymerase III subunit delta'; Validated; Region: PRK07940 233413009301 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413009302 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 233413009303 dimerization interface [polypeptide binding]; other site 233413009304 cyclase homology domain; Region: CHD; cd07302 233413009305 nucleotidyl binding site; other site 233413009306 metal binding site [ion binding]; metal-binding site 233413009307 dimer interface [polypeptide binding]; other site 233413009308 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 233413009309 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 233413009310 active site 233413009311 interdomain interaction site; other site 233413009312 putative metal-binding site [ion binding]; other site 233413009313 nucleotide binding site [chemical binding]; other site 233413009314 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 233413009315 domain I; other site 233413009316 phosphate binding site [ion binding]; other site 233413009317 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 233413009318 domain II; other site 233413009319 domain III; other site 233413009320 nucleotide binding site [chemical binding]; other site 233413009321 DNA binding groove [nucleotide binding] 233413009322 catalytic site [active] 233413009323 domain IV; other site 233413009324 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 233413009325 DNA-binding site [nucleotide binding]; DNA binding site 233413009326 RNA-binding motif; other site 233413009327 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 233413009328 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 233413009329 ATP binding site [chemical binding]; other site 233413009330 putative Mg++ binding site [ion binding]; other site 233413009331 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 233413009332 nucleotide binding region [chemical binding]; other site 233413009333 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 233413009334 PE family; Region: PE; pfam00934 233413009335 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 233413009336 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 233413009337 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 233413009338 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 233413009339 Walker A motif; other site 233413009340 hexamer interface [polypeptide binding]; other site 233413009341 ATP binding site [chemical binding]; other site 233413009342 Walker B motif; other site 233413009343 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 233413009344 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 233413009345 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413009346 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 233413009347 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 233413009348 Walker A/P-loop; other site 233413009349 ATP binding site [chemical binding]; other site 233413009350 Q-loop/lid; other site 233413009351 ABC transporter signature motif; other site 233413009352 Walker B; other site 233413009353 D-loop; other site 233413009354 H-loop/switch region; other site 233413009355 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 233413009356 Walker A/P-loop; other site 233413009357 ATP binding site [chemical binding]; other site 233413009358 Q-loop/lid; other site 233413009359 ABC transporter signature motif; other site 233413009360 Walker B; other site 233413009361 D-loop; other site 233413009362 H-loop/switch region; other site 233413009363 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 233413009364 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 233413009365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413009366 ABC-ATPase subunit interface; other site 233413009367 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 233413009368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 233413009369 dimer interface [polypeptide binding]; other site 233413009370 conserved gate region; other site 233413009371 ABC-ATPase subunit interface; other site 233413009372 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 233413009373 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 233413009374 acetyl-CoA synthetase; Provisional; Region: PRK00174 233413009375 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 233413009376 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413009377 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 233413009378 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 233413009379 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 233413009380 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 233413009381 putative active site [active] 233413009382 putative CoA binding site [chemical binding]; other site 233413009383 nudix motif; other site 233413009384 metal binding site [ion binding]; metal-binding site 233413009385 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 233413009386 catalytic residues [active] 233413009387 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 233413009388 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 233413009389 minor groove reading motif; other site 233413009390 helix-hairpin-helix signature motif; other site 233413009391 substrate binding pocket [chemical binding]; other site 233413009392 active site 233413009393 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 233413009394 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 233413009395 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 233413009396 ligand binding site [chemical binding]; other site 233413009397 flexible hinge region; other site 233413009398 Helix-turn-helix domains; Region: HTH; cl00088 233413009399 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413009400 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 233413009401 homotrimer interaction site [polypeptide binding]; other site 233413009402 putative active site [active] 233413009403 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 233413009404 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 233413009405 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 233413009406 P loop; other site 233413009407 Nucleotide binding site [chemical binding]; other site 233413009408 DTAP/Switch II; other site 233413009409 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 233413009410 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 233413009411 DTAP/Switch II; other site 233413009412 Switch I; other site 233413009413 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 233413009414 Transcription factor WhiB; Region: Whib; pfam02467 233413009415 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 233413009416 Transglycosylase; Region: Transgly; cl07896 233413009417 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413009418 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 233413009419 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 233413009420 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 233413009421 putative active site [active] 233413009422 putative metal binding site [ion binding]; other site 233413009423 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 233413009424 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 233413009425 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413009426 catalytic residue [active] 233413009427 Cytochrome P450; Region: p450; cl12078 233413009428 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 233413009429 anti sigma factor interaction site; other site 233413009430 regulatory phosphorylation site [posttranslational modification]; other site 233413009431 GatB domain; Region: GatB_Yqey; cl11497 233413009432 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 233413009433 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 233413009434 MoxR-like ATPases [General function prediction only]; Region: COG0714 233413009435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413009436 Walker A motif; other site 233413009437 ATP binding site [chemical binding]; other site 233413009438 Walker B motif; other site 233413009439 arginine finger; other site 233413009440 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 233413009441 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 233413009442 Integral membrane protein DUF95; Region: DUF95; cl00572 233413009443 RDD family; Region: RDD; cl00746 233413009444 Mb3721c, glpKb, len: 326 aa. Equivalent to 3' end of Rv3696c, len: 517 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 326 aa overlap). Probable glpK, glycerol kinase (EC 2.7.1.30), equivalent to Q9CB81|GLPK_MYCLE|ML2314 GLYCEROL KINASE from Mycobacterium leprae (508 aa), FASTA scores: opt: 3120, E(): 4.7e-189, (91.35% identity in 508 aa overlap). Also highly similar to others e.g. Q9RJM2|GLPK from Streptomyces coelicolor (507 aa), FASTA scores: opt: 2606, E(): 1.1e-156, (75.35% identity in 503 aa overlap); Q9ADA7|GLPK from Streptomyces coelicolor (512 aa) FASTA scores: opt: 2002, E(): 1.3e-118, (59.05% identity in 503 aa overlap); Q9X1E4|GLK2_THEMA|TM1430 from Thermotoga maritima (496 aa), FASTA scores: opt: 1838, E(): 2.7e-108, (54.8% identity in 498 aa overlap); P08859|GLPK_ECOLI|B3926 from Escherichia coli strain K12 (501 aa), FASTA scores: opt: 1740, E(): 4.1e-102, (52.3% identity in 499 aa overlap); etc. Contains PS00933 FGGY family of carbohydrate kinases signature 1, PS00070 Aldehyde dehydrogenases cysteine active site, PS00445 FGGY family of carbohydrate kinases signature 2. BELONGS TO THE FUCOKINASE / GLUCONOKINASE / GLYCEROKINASE / XYLULOKINase. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, glpK exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-g), splits glpK into 2 parts, glpKa and glpKb and removes activity.;PROBABLE GLYCEROL KINASE GLPKB [SECOND PART] (ATP:GLYCEROL 3-PHOSPHOTRANSFERASE)(GLYCEROKINASE) (GK) 233413009445 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 233413009446 catalytic site [active] 233413009447 metal binding site [ion binding]; metal-binding site 233413009448 carbohydrate binding site [chemical binding]; other site 233413009449 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 233413009450 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 233413009451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413009452 S-adenosylmethionine binding site [chemical binding]; other site 233413009453 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 233413009454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413009455 catalytic residue [active] 233413009456 Uncharacterized conserved protein [Function unknown]; Region: COG4301 233413009457 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 233413009458 TIGR03442 family protein; Region: TIGR03442 233413009459 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 233413009460 putative active site [active] 233413009461 putative dimer interface [polypeptide binding]; other site 233413009462 TIGR03440 family protein; Region: unchr_TIGR03440 233413009463 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 233413009464 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 233413009465 PknH-like extracellular domain; Region: PknH_C; pfam14032 233413009466 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 233413009467 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 233413009468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009469 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 233413009470 aspartate kinase; Reviewed; Region: PRK06635 233413009471 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 233413009472 putative nucleotide binding site [chemical binding]; other site 233413009473 putative catalytic residues [active] 233413009474 putative Mg ion binding site [ion binding]; other site 233413009475 putative aspartate binding site [chemical binding]; other site 233413009476 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 233413009477 putative allosteric regulatory site; other site 233413009478 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 233413009479 putative allosteric regulatory residue; other site 233413009480 2-isopropylmalate synthase; Validated; Region: PRK03739 233413009481 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 233413009482 active site 233413009483 catalytic residues [active] 233413009484 metal binding site [ion binding]; metal-binding site 233413009485 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 233413009486 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 233413009487 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 233413009488 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 233413009489 active site 233413009490 substrate binding site [chemical binding]; other site 233413009491 catalytic site [active] 233413009492 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 233413009493 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 233413009494 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 233413009495 catalytic triad [active] 233413009496 recombination protein RecR; Reviewed; Region: recR; PRK00076 233413009497 RecR protein; Region: RecR; pfam02132 233413009498 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 233413009499 putative active site [active] 233413009500 putative metal-binding site [ion binding]; other site 233413009501 tetramer interface [polypeptide binding]; other site 233413009502 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 233413009503 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 233413009504 active site 233413009505 metal binding site [ion binding]; metal-binding site 233413009506 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 233413009507 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 233413009508 FAD binding domain; Region: FAD_binding_4; pfam01565 233413009509 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 233413009510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413009511 S-adenosylmethionine binding site [chemical binding]; other site 233413009512 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 233413009513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413009514 Walker A motif; other site 233413009515 ATP binding site [chemical binding]; other site 233413009516 Walker B motif; other site 233413009517 arginine finger; other site 233413009518 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 233413009519 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 233413009520 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413009521 catalytic residue [active] 233413009522 Cutinase; Region: Cutinase; cl15711 233413009523 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 233413009524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009525 NAD(P) binding site [chemical binding]; other site 233413009526 active site 233413009527 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 233413009528 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 233413009529 putative NAD(P) binding site [chemical binding]; other site 233413009530 catalytic Zn binding site [ion binding]; other site 233413009531 Uncharacterized conserved protein [Function unknown]; Region: COG3349 233413009532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009533 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 233413009534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 233413009535 putative substrate translocation pore; other site 233413009536 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 233413009537 ligand binding site [chemical binding]; other site 233413009538 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 233413009539 active site 233413009540 nucleophile elbow; other site 233413009541 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 233413009542 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 233413009543 FeS/SAM binding site; other site 233413009544 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 233413009545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 233413009546 S-adenosylmethionine binding site [chemical binding]; other site 233413009547 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 233413009548 nucleotide binding site [chemical binding]; other site 233413009549 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 233413009550 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 233413009551 active site 233413009552 DNA binding site [nucleotide binding] 233413009553 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 233413009554 DNA binding site [nucleotide binding] 233413009555 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 233413009556 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 233413009557 nudix motif; other site 233413009558 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413009559 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413009560 Adenosine specific kinase; Region: Adenosine_kin; cl00796 233413009561 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 233413009562 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 233413009563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 233413009564 Uncharacterized conserved protein [Function unknown]; Region: COG2966 233413009565 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 233413009566 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 233413009567 Mb3765c, PPE66, len: 118 aa. Equivalent to 3' end of Rv3738c, len: 315 aa, from Mycobacterium tuberculosis strain H37Rv, (98.1% identity in 105 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O53265|Rv3018c|MTV012.32c (434 aa), FASTA scores: opt: 464, E(): 2.2e-17, (47.05% identity in 338 aa overlap). Probably a continuation of the upstream ORF MTV025.87c. At position 97470-72 a stop codon is present which interrupts a possibly longer ORF, observed in related ORFs MTV012_32 or MTCY21B4_4. The sequence has been checked and no errors were detected. A similar situation, but with a frameshift separating the ORFs is found in MTV012_36/MTV012_35. Sequence similarity is also seen with MTCY251_15; MTCY261_19; MLCB2492_30 from Mycobacterium leprae; MTCY10G2_10; MTY21C12_9; MTCI125_26; MTCY164_36; MTCY6A4_1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a deletion of 1166 bp leads to the loss of the NH2 part of PPE66 and of Rv3739c compared to its homolog in Mycobacterium tuberculosis strain H37Rv.;PPE FAMILY PROTEIN 233413009568 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 233413009569 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 233413009570 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 233413009571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009572 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 233413009573 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 233413009574 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 233413009575 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 233413009576 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413009577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 233413009578 dimerization interface [polypeptide binding]; other site 233413009579 putative DNA binding site [nucleotide binding]; other site 233413009580 putative Zn2+ binding site [ion binding]; other site 233413009581 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 233413009582 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 233413009583 DNA binding residues [nucleotide binding] 233413009584 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 233413009585 active site 233413009586 Int/Topo IB signature motif; other site 233413009587 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 233413009588 nucleoside/Zn binding site; other site 233413009589 dimer interface [polypeptide binding]; other site 233413009590 catalytic motif [active] 233413009591 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 233413009592 prephenate dehydrogenase; Validated; Region: PRK06545 233413009593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009594 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 233413009595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 233413009596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 233413009597 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 233413009598 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 233413009599 Walker A/P-loop; other site 233413009600 ATP binding site [chemical binding]; other site 233413009601 Q-loop/lid; other site 233413009602 ABC transporter signature motif; other site 233413009603 Walker B; other site 233413009604 D-loop; other site 233413009605 H-loop/switch region; other site 233413009606 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 233413009607 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 233413009608 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 233413009609 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 233413009610 putative active site [active] 233413009611 putative substrate binding site [chemical binding]; other site 233413009612 ATP binding site [chemical binding]; other site 233413009613 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 233413009614 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413009615 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 233413009616 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 233413009617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 233413009618 dimer interface [polypeptide binding]; other site 233413009619 phosphorylation site [posttranslational modification] 233413009620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 233413009621 ATP binding site [chemical binding]; other site 233413009622 Mg2+ binding site [ion binding]; other site 233413009623 G-X-G motif; other site 233413009624 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 233413009625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 233413009626 active site 233413009627 phosphorylation site [posttranslational modification] 233413009628 intermolecular recognition site; other site 233413009629 dimerization interface [polypeptide binding]; other site 233413009630 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 233413009631 DNA binding site [nucleotide binding] 233413009632 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 233413009633 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413009634 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 233413009635 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 233413009636 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 233413009637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 233413009638 homodimer interface [polypeptide binding]; other site 233413009639 catalytic residue [active] 233413009640 DinB superfamily; Region: DinB_2; cl00986 233413009641 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 233413009642 enoyl-CoA hydratase; Provisional; Region: PRK06142 233413009643 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 233413009644 substrate binding site [chemical binding]; other site 233413009645 oxyanion hole (OAH) forming residues; other site 233413009646 trimer interface [polypeptide binding]; other site 233413009647 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 233413009648 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 233413009649 Domain of unknown function DUF222; Region: DUF222; pfam02720 233413009650 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 233413009651 active site 233413009652 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 233413009653 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 233413009654 NAD(P) binding site [chemical binding]; other site 233413009655 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 233413009656 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 233413009657 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 233413009658 catalytic residue [active] 233413009659 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 233413009660 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 233413009661 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 233413009662 Walker A/P-loop; other site 233413009663 ATP binding site [chemical binding]; other site 233413009664 Q-loop/lid; other site 233413009665 ABC transporter signature motif; other site 233413009666 Walker B; other site 233413009667 D-loop; other site 233413009668 H-loop/switch region; other site 233413009669 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 233413009670 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 233413009671 active site 233413009672 ABC-2 type transporter; Region: ABC2_membrane; cl11417 233413009673 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 233413009674 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 233413009675 NAD binding site [chemical binding]; other site 233413009676 substrate binding site [chemical binding]; other site 233413009677 active site 233413009678 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 233413009679 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 233413009680 active site 233413009681 Peptidase family M23; Region: Peptidase_M23; pfam01551 233413009682 Leucine carboxyl methyltransferase; Region: LCM; cl01306 233413009683 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 233413009684 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 233413009685 GtrA-like protein; Region: GtrA; cl00971 233413009686 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 233413009687 FAD binding domain; Region: FAD_binding_4; pfam01565 233413009688 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 233413009689 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 233413009690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009691 NAD(P) binding site [chemical binding]; other site 233413009692 active site 233413009693 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 233413009694 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 233413009695 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 233413009696 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 233413009697 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 233413009698 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413009699 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 233413009700 FAD binding site [chemical binding]; other site 233413009701 substrate binding site [chemical binding]; other site 233413009702 catalytic residues [active] 233413009703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 233413009704 Transposase; Region: DDE_Tnp_ISL3; pfam01610 233413009705 Transposase; Region: DDE_Tnp_ISL3; pfam01610 233413009706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 233413009707 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 233413009708 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 233413009709 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 233413009710 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413009711 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413009712 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 233413009713 active site 233413009714 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 233413009715 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413009716 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413009717 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 233413009718 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 233413009719 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 233413009720 Cutinase; Region: Cutinase; pfam01083 233413009721 Predicted esterase [General function prediction only]; Region: COG0627 233413009722 Predicted esterase [General function prediction only]; Region: COG0627 233413009723 UbiA prenyltransferase family; Region: UbiA; cl00337 233413009724 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 233413009725 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 233413009726 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 233413009727 active site 233413009728 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 233413009729 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 233413009730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009732 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 233413009733 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 233413009734 amidase catalytic site [active] 233413009735 Zn binding residues [ion binding]; other site 233413009736 substrate binding site [chemical binding]; other site 233413009737 LGFP repeat; Region: LGFP; pfam08310 233413009738 PE family; Region: PE; pfam00934 233413009739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 233413009740 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 233413009741 active site 233413009742 motif I; other site 233413009743 motif II; other site 233413009744 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 233413009745 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 233413009746 putative acyl-acceptor binding pocket; other site 233413009747 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 233413009748 putative acyl-acceptor binding pocket; other site 233413009749 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 233413009750 putative acyl-acceptor binding pocket; other site 233413009751 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: APH; cd05150 233413009752 Phosphotransferase enzyme family; Region: APH; pfam01636 233413009753 active site 233413009754 ATP binding site [chemical binding]; other site 233413009755 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 233413009756 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 233413009757 iron-sulfur cluster [ion binding]; other site 233413009758 [2Fe-2S] cluster binding site [ion binding]; other site 233413009759 Condensation domain; Region: Condensation; pfam00668 233413009760 LysE type translocator; Region: LysE; cl00565 233413009761 Cutinase; Region: Cutinase; cl15711 233413009762 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 233413009763 Condensation domain; Region: Condensation; pfam00668 233413009764 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 233413009765 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 233413009766 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 233413009767 active site 233413009768 Acyl transferase domain; Region: Acyl_transf_1; cl08282 233413009769 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 233413009770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009771 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 233413009772 Enoylreductase; Region: PKS_ER; smart00829 233413009773 NAD(P) binding site [chemical binding]; other site 233413009774 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 233413009775 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 233413009776 putative NADP binding site [chemical binding]; other site 233413009777 active site 233413009778 Phosphopantetheine attachment site; Region: PP-binding; cl09936 233413009779 acyl-CoA synthetase; Validated; Region: PRK05850 233413009780 AMP-binding enzyme; Region: AMP-binding; cl15778 233413009781 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 233413009782 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 233413009783 Probable transposase; Region: OrfB_IS605; pfam01385 233413009784 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 233413009785 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 233413009786 catalytic residues [active] 233413009787 catalytic nucleophile [active] 233413009788 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 233413009789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009790 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 233413009791 Helix-turn-helix domains; Region: HTH; cl00088 233413009792 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 233413009793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413009794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413009795 Cupin domain; Region: Cupin_2; cl09118 233413009796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 233413009797 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 233413009798 seryl-tRNA synthetase; Provisional; Region: PRK05431 233413009799 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 233413009800 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 233413009801 dimer interface [polypeptide binding]; other site 233413009802 active site 233413009803 motif 1; other site 233413009804 motif 2; other site 233413009805 motif 3; other site 233413009806 Septum formation; Region: Septum_form; pfam13845 233413009807 Septum formation; Region: Septum_form; pfam13845 233413009808 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 233413009809 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 233413009810 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 233413009811 catalytic core [active] 233413009812 prephenate dehydratase; Provisional; Region: PRK11898 233413009813 Prephenate dehydratase; Region: PDT; pfam00800 233413009814 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 233413009815 putative L-Phe binding site [chemical binding]; other site 233413009816 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 233413009817 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 233413009818 Ferritin-like domain; Region: Ferritin; pfam00210 233413009819 ferroxidase diiron center [ion binding]; other site 233413009820 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 233413009821 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 233413009822 putative active site [active] 233413009823 catalytic site [active] 233413009824 putative metal binding site [ion binding]; other site 233413009825 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 233413009826 Transposase; Region: DEDD_Tnp_IS110; pfam01548 233413009827 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 233413009828 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 233413009829 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 233413009830 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 233413009831 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 233413009832 Fimbrial protein; Region: Fimbrial; cl01416 233413009833 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 233413009834 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 233413009835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 233413009836 Helix-turn-helix domains; Region: HTH; cl00088 233413009837 hypothetical protein; Provisional; Region: PRK07945 233413009838 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 233413009839 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 233413009840 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 233413009841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009842 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 233413009843 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 233413009844 active site 233413009845 dimer interface [polypeptide binding]; other site 233413009846 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 233413009847 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 233413009848 active site 233413009849 FMN binding site [chemical binding]; other site 233413009850 substrate binding site [chemical binding]; other site 233413009851 3Fe-4S cluster binding site [ion binding]; other site 233413009852 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 233413009853 domain interface; other site 233413009854 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 233413009855 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 233413009856 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413009857 EspG family; Region: ESX-1_EspG; pfam14011 233413009858 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 233413009859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413009860 Walker A motif; other site 233413009861 ATP binding site [chemical binding]; other site 233413009862 Walker B motif; other site 233413009863 arginine finger; other site 233413009864 Protein of unknown function (DUF690); Region: DUF690; cl04939 233413009865 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 233413009866 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413009867 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 233413009868 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413009869 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413009870 PE family; Region: PE; pfam00934 233413009871 PPE family; Region: PPE; pfam00823 233413009872 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413009873 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413009874 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 233413009875 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 233413009876 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 233413009877 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 233413009878 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 233413009879 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 233413009880 active site 233413009881 catalytic residues [active] 233413009882 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 233413009883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 233413009884 Walker A motif; other site 233413009885 ATP binding site [chemical binding]; other site 233413009886 Walker B motif; other site 233413009887 arginine finger; other site 233413009888 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 233413009889 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 233413009890 catalytic residues [active] 233413009891 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 233413009892 active site 233413009893 catalytic residues [active] 233413009894 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 233413009895 EspG family; Region: ESX-1_EspG; pfam14011 233413009896 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413009897 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413009898 PPE family; Region: PPE; pfam00823 233413009899 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 233413009900 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413009901 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413009902 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 233413009903 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 233413009904 Protein of unknown function (DUF690); Region: DUF690; cl04939 233413009905 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 233413009906 Mb3929c, -, len: 247 aa. Equivalent to 5' end of Rv3899c, len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, (90.8% identity in 130 aa overlap). Conserved hypothetical protein, similar in part to proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551. Region between aa 29-80 is strictly identical to P96909 HYPOTHETICAL 15.1 KDA PROTEIN (FRAGMENT) (143 aa) FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap); and the N-terminal end is highly similar, but longer 65 aa, to O07266 HYPOTHETICAL 13.7 KDA PROTEIN (FRAGMENT) (143 aa), FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap). Highly similar to C-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 HYPOTHETICAL 73.6 KDA PROTEIN (721 aa), FASTA scores: opt: 1388, E(): 1.5e-48, (55.25% identity in 409 aa overlap). And similar to P71599|Rv0029|MTCY10H4.29 HYPOTHETICAL 39.6 KDA PROTEIN (365 aa), FASTA scores: opt: 403, E(): 1.7e-09, (33.75% identity in 252 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct. In Mycobacterium tuberculosis strain H37Rv, Rv3899c (len: 410 aa) exists as a single gene on a single reading frame. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product.;CONSERVED HYPOTHETICAL PROTEIN 233413009907 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 233413009908 Proteins of 100 residues with WXG; Region: WXG100; cl02005 233413009909 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 233413009910 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 233413009911 active site 233413009912 NTP binding site [chemical binding]; other site 233413009913 metal binding triad [ion binding]; metal-binding site 233413009914 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 233413009915 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 233413009916 Zn2+ binding site [ion binding]; other site 233413009917 Mg2+ binding site [ion binding]; other site 233413009918 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 233413009919 active site 233413009920 Ap6A binding site [chemical binding]; other site 233413009921 nudix motif; other site 233413009922 metal binding site [ion binding]; metal-binding site 233413009923 MviN-like protein; Region: MVIN; pfam03023 233413009924 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 233413009925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 233413009926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 233413009927 Mb3942, sigMb, len: 62 aa. Equivalent to 3' end of Rv3911, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 62 aa overlap). Possible sigM, alternative RNA polymerase sigma factor (see citation below), highly similar to others e.g. Q9S6U3|SCH24.14c (alias O86856|SIGT) RNA POLYMERASE SIGMA FACTOR from Streptomyces coelicolor (236 aa), FASTA scores: opt: 336, E(): 2.8e-13, (41.5% identity in 212 aa overlap); Q98KG8|MLR1481 PROBABLE RNA POLYMERASE SIGMA SUBUNIT from Rhizobium loti (Mesorhizobium loti) (307 aa), FASTA scores: opt: 221, E(): 2.9e-06, (32.95% identity in 179 aa overlap); Q9A4S9|CC2751 RNA POLYMERASE SIGMA FACTOR from Caulobacter crescentus (186 aa), FASTA scores: opt: 217, E(): 3.3e-06, (36.95% identity in 138 aa overlap); etc. Also similarity with other mycobacterial factors e.g. O06289|SIGE|Rv1221|MTCI61.04 RNA POLYMERASE SIGMA FACTOR from Mycobacterium tuberculosis (257 aa), FASTA scores: opt: 193, E(): 0.00012, (33.15% identity in 163 aa overlap); and O05735|SIGE RNA POLYMERASE SIGMA FACTOR from Mycobacterium avium (251 aa), FASTA scores: opt: 192, E(): 0.00014, (33.15% identity in 163 aa overlap). Equivalent to AAK48395|MT4030 RNA POLYMERASE SIGMA-70 FACTOR from Mycobacterium tuberculosis strain CDC1551 (196 aa) but without similarity at the C-terminal end. BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, sigM exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2bp to 1bp substitution (cg-t) splits sigM into 2 parts, sigMa and sigMb.;POSSIBLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGMb [SECOND PART] 233413009928 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 233413009929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 233413009930 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 233413009931 catalytic residues [active] 233413009932 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 233413009933 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 233413009934 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 233413009935 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 233413009936 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 233413009937 active site 233413009938 metal binding site [ion binding]; metal-binding site 233413009939 ParB-like partition proteins; Region: parB_part; TIGR00180 233413009940 ParB-like nuclease domain; Region: ParBc; cl02129 233413009941 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 233413009942 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 233413009943 P-loop; other site 233413009944 Magnesium ion binding site [ion binding]; other site 233413009945 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 233413009946 Magnesium ion binding site [ion binding]; other site 233413009947 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 233413009948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 233413009949 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 233413009950 G-X-X-G motif; other site 233413009951 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 233413009952 RxxxH motif; other site 233413009953 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 233413009954 Domain of unknown function DUF37; Region: DUF37; cl00506 233413009955 Ribonuclease P; Region: Ribonuclease_P; cl00457 233413009956 Ribosomal protein L34; Region: Ribosomal_L34; cl00370