-- dump date 20120504_152941 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_001840829.1 184152626 6229865 241..1317 1 NC_010604.1 replication protein, repA 1317 repA 6229865 repA Mycobacterium marinum M replication protein, repA YP_001840829.1 241 D 216594 CDS YP_001840830.1 184152627 6229848 1634..4966 1 NC_010604.1 similar to AA sequence INSD:AY056023; ATP-dependent exoDNAse (exonuclease V) 4966 6229848 MMAR_p03 Mycobacterium marinum M ATP-dependent exoDNAse (exonuclease V) YP_001840830.1 1634 D 216594 CDS YP_001840831.1 184152628 6229854 complement(4978..5739) 1 NC_010604.1 hypothetical protein 5739 6229854 MMAR_p04 Mycobacterium marinum M hypothetical protein YP_001840831.1 4978 R 216594 CDS YP_001840832.1 184152629 6229853 complement(5736..8180) 1 NC_010604.1 hypothetical protein 8180 6229853 MMAR_p05 Mycobacterium marinum M hypothetical protein YP_001840832.1 5736 R 216594 CDS YP_001840833.1 184152630 6229856 complement(8180..8707) 1 NC_010604.1 hypothetical protein 8707 6229856 MMAR_p06 Mycobacterium marinum M hypothetical protein YP_001840833.1 8180 R 216594 CDS YP_001840834.1 184152631 6229871 complement(8874..9464) 1 NC_010604.1 hypothetical protein 9464 6229871 MMAR_p07 Mycobacterium marinum M hypothetical protein YP_001840834.1 8874 R 216594 CDS YP_001840835.1 184152632 6229873 complement(9522..10106) 1 NC_010604.1 site-specific DNA recombinase 10106 6229873 MMAR_p08 Mycobacterium marinum M site-specific DNA recombinase YP_001840835.1 9522 R 216594 CDS YP_001840836.1 184152633 6229860 complement(10305..11657) 1 NC_010604.1 pyridine nucleotide-disulfide oxidoreductase 11657 6229860 MMAR_p09 Mycobacterium marinum M pyridine nucleotide-disulfide oxidoreductase YP_001840836.1 10305 R 216594 CDS YP_001840837.1 184152634 6229850 complement(11654..12310) 1 NC_010604.1 cleaves the carbon-mercury bond of organomercuric compounds; alkylmercury lyase 12310 merB 6229850 merB Mycobacterium marinum M alkylmercury lyase YP_001840837.1 11654 R 216594 CDS YP_001840838.1 184152635 6229852 complement(12357..12872) 1 NC_010604.1 Contains four transmembrane domains.; mercuric transporter MerH 12872 merH 6229852 merH Mycobacterium marinum M mercuric transporter MerH YP_001840838.1 12357 R 216594 CDS YP_001840839.1 184152636 6229859 complement(12901..14319) 1 NC_010604.1 mercuric reductase, MerA 14319 merA 6229859 merA Mycobacterium marinum M mercuric reductase, MerA YP_001840839.1 12901 R 216594 CDS YP_001840840.1 184152637 6229869 14458..14841 1 NC_010604.1 Proposed that MerR binds to inverted repeat and represses transcription of merA in the absence of mercuric ions and negatively regulates its own expression in the presence of mercuric ions.; transcriptional repressor protein, MerR 14841 6229869 MMAR_p13 Mycobacterium marinum M transcriptional repressor protein, MerR YP_001840840.1 14458 D 216594 CDS YP_001840841.1 184152638 6229872 14841..15275 1 NC_010604.1 mercuric transport protein, MerT 15275 merT 6229872 merT Mycobacterium marinum M mercuric transport protein, MerT YP_001840841.1 14841 D 216594 CDS YP_001840842.1 184152639 6229847 15272..15868 1 NC_010604.1 site-specific DNA recombinase 15868 6229847 MMAR_p15 Mycobacterium marinum M site-specific DNA recombinase YP_001840842.1 15272 D 216594 CDS YP_001840843.1 184152640 6229870 15865..16044 1 NC_010604.1 hypothetical protein 16044 6229870 MMAR_p16 Mycobacterium marinum M hypothetical protein YP_001840843.1 15865 D 216594 CDS YP_001840844.1 184152641 6229855 16052..16195 1 NC_010604.1 hypothetical protein 16195 6229855 MMAR_p17 Mycobacterium marinum M hypothetical protein YP_001840844.1 16052 D 216594 CDS YP_001840845.1 184152642 6229849 complement(16219..16515) 1 NC_010604.1 hypothetical protein 16515 6229849 MMAR_p18 Mycobacterium marinum M hypothetical protein YP_001840845.1 16219 R 216594 CDS YP_001840846.1 184152643 6229863 complement(16515..16748) 1 NC_010604.1 hypothetical protein 16748 6229863 MMAR_p19 Mycobacterium marinum M hypothetical protein YP_001840846.1 16515 R 216594 CDS YP_001840847.1 184152644 6229862 complement(16837..17277) 1 NC_010604.1 hypothetical protein 17277 6229862 MMAR_p20 Mycobacterium marinum M hypothetical protein YP_001840847.1 16837 R 216594 CDS YP_001840848.1 184152645 6229851 complement(17274..18095) 1 NC_010604.1 Fis family transcriptional regulator 18095 6229851 MMAR_p21 Mycobacterium marinum M Fis family transcriptional regulator YP_001840848.1 17274 R 216594 CDS YP_001840849.1 184152646 6229866 18462..19307 1 NC_010604.1 hypothetical protein 19307 6229866 MMAR_p22 Mycobacterium marinum M hypothetical protein YP_001840849.1 18462 D 216594 CDS YP_001840850.1 184152647 6229861 19405..20235 1 NC_010604.1 chromosome partitioning protein, ParA 20235 parA 6229861 parA Mycobacterium marinum M chromosome partitioning protein, ParA YP_001840850.1 19405 D 216594 CDS YP_001840851.1 184152648 6229868 20232..20624 1 NC_010604.1 hypothetical protein 20624 6229868 MMAR_p24 Mycobacterium marinum M hypothetical protein YP_001840851.1 20232 D 216594 CDS YP_001840852.1 184152649 6229874 21101..21307 1 NC_010604.1 contains two transmembrane domains and a potential signal peptide sequence; hypothetical protein 21307 6229874 MMAR_p25 Mycobacterium marinum M hypothetical protein YP_001840852.1 21101 D 216594 CDS YP_001840853.1 184152650 6229867 complement(21510..21737) 1 NC_010604.1 hypothetical protein 21737 6229867 MMAR_p27 Mycobacterium marinum M hypothetical protein YP_001840853.1 21510 R 216594 CDS YP_001840854.1 184152651 6229846 21820..22098 1 NC_010604.1 hypothetical protein 22098 6229846 MMAR_p30 Mycobacterium marinum M hypothetical protein YP_001840854.1 21820 D 216594 CDS YP_001840855.1 184152652 6229864 22110..22430 1 NC_010604.1 hypothetical protein 22430 6229864 MMAR_p31 Mycobacterium marinum M hypothetical protein YP_001840855.1 22110 D 216594 CDS YP_001840856.1 184152653 6229857 complement(22453..22839) 1 NC_010604.1 hypothetical protein 22839 6229857 MMAR_p32 Mycobacterium marinum M hypothetical protein YP_001840856.1 22453 R 216594 CDS YP_001840857.1 184152654 6229858 complement(22833..23135) 1 NC_010604.1 hypothetical protein 23135 6229858 MMAR_p33 Mycobacterium marinum M hypothetical protein YP_001840857.1 22833 R 216594 CDS YP_001848327.1 183980036 6229632 1..1533 1 NC_010612.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1533 dnaA 6229632 dnaA Mycobacterium marinum M chromosomal replication initiation protein YP_001848327.1 1 D 216594 CDS YP_001848328.1 183980037 6224526 2074..3282 1 NC_010612.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3282 dnaN 6224526 dnaN Mycobacterium marinum M DNA polymerase III subunit beta YP_001848328.1 2074 D 216594 CDS YP_001848329.1 183980038 6224527 3303..4460 1 NC_010612.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4460 recF 6224527 recF Mycobacterium marinum M recombination protein F YP_001848329.1 3303 D 216594 CDS YP_001848330.1 183980039 6224528 4457..5020 1 NC_010612.1 hypothetical protein 5020 6224528 MMAR_0004 Mycobacterium marinum M hypothetical protein YP_001848330.1 4457 D 216594 CDS YP_001848331.1 183980040 6224529 5230..7308 1 NC_010612.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 7308 gyrB 6224529 gyrB Mycobacterium marinum M DNA gyrase subunit B YP_001848331.1 5230 D 216594 CDS YP_001848332.1 183980041 6224530 7348..9867 1 NC_010612.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 9867 gyrA 6224530 gyrA Mycobacterium marinum M DNA gyrase subunit A YP_001848332.1 7348 D 216594 CDS YP_001848333.1 183980042 6224531 9951..10853 1 NC_010612.1 hypothetical protein 10853 6224531 MMAR_0007 Mycobacterium marinum M hypothetical protein YP_001848333.1 9951 D 216594 CDS YP_001848334.1 183980043 6224534 11363..12199 1 NC_010612.1 hypothetical protein 12199 6224534 MMAR_0008 Mycobacterium marinum M hypothetical protein YP_001848334.1 11363 D 216594 CDS YP_001848335.1 183980044 6224535 complement(12227..12988) 1 NC_010612.1 transcription; transcriptional regulator 12988 6224535 MMAR_0009 Mycobacterium marinum M transcriptional regulator YP_001848335.1 12227 R 216594 CDS YP_001848336.1 183980045 6224536 complement(13099..13527) 1 NC_010612.1 hypothetical protein 13527 6224536 MMAR_0010 Mycobacterium marinum M hypothetical protein YP_001848336.1 13099 R 216594 CDS YP_001848337.1 183980046 6224537 13692..14240 1 NC_010612.1 ppiases accelerate the folding of proteins [catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides]; peptidyl-prolyl cis-trans isomerase A, PpiA 14240 ppiA 6224537 ppiA Mycobacterium marinum M peptidyl-prolyl cis-trans isomerase A, PpiA YP_001848337.1 13692 D 216594 CDS YP_001848338.1 183980047 6224538 complement(14251..14676) 1 NC_010612.1 hypothetical protein 14676 6224538 MMAR_0012 Mycobacterium marinum M hypothetical protein YP_001848338.1 14251 R 216594 CDS YP_001848339.1 183980048 6224539 complement(14832..15113) 1 NC_010612.1 integral membrane protein involved in inhibition of the Z-ring formation; putative septation inhibitor protein 15113 6224539 MMAR_0013 Mycobacterium marinum M putative septation inhibitor protein YP_001848339.1 14832 R 216594 CDS YP_001848340.1 183980049 6224540 15242..15985 1 NC_010612.1 hypothetical protein 15985 6224540 MMAR_0014 Mycobacterium marinum M hypothetical protein YP_001848340.1 15242 D 216594 CDS YP_001848341.1 183980050 6224541 16023..16709 1 NC_010612.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 16709 trpG 6224541 trpG Mycobacterium marinum M para-aminobenzoate synthase component II YP_001848341.1 16023 D 216594 CDS YP_001848342.1 183980051 6224542 complement(16687..18567) 1 NC_010612.1 involved in signal transduction (via phosphorylation). thought to regulate cell division/differentiation. can phosphorylate the peptide substrate myelin basic protein (MBP) [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase B PknB 18567 pknB 6224542 pknB Mycobacterium marinum M serine/threonine-protein kinase B PknB YP_001848342.1 16687 R 216594 CDS YP_001848343.1 183980052 6224543 complement(18564..19922) 1 NC_010612.1 involved in signal transduction (via phosphorylation). thought to regulate morphological changes associated with cell division/differentiation process. phosphorylates at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase a PknA 19922 pknA 6224543 pknA Mycobacterium marinum M serine/threonine-protein kinase a PknA YP_001848343.1 18564 R 216594 CDS YP_001848344.1 183980053 6224544 complement(19919..21394) 1 NC_010612.1 involved in peptidoglycan synthesis (at the final stages). cell wall formation; PbpA is supposed to be responsible for the determination of the rod shape of the cell. its synthesizes cross-linked peptidoglycan from lipid intermediates; penicillin-binding protein PbpA 21394 pbpA 6224544 pbpA Mycobacterium marinum M penicillin-binding protein PbpA YP_001848344.1 19919 R 216594 CDS YP_001848345.1 183980054 6224545 complement(21391..22800) 1 NC_010612.1 this is a septum-peptidoglycan biosynthetic protein, involved in cell wall formation. plays a role in the stabilization of the FtsZ ring during cell division; cell division protein RodA 22800 rodA 6224545 rodA Mycobacterium marinum M cell division protein RodA YP_001848345.1 21391 R 216594 CDS YP_001848346.1 183980055 6224546 complement(22797..24356) 1 NC_010612.1 involved in regulation (using dephosphorylation of a specific phosphorylated substrate); serine/threonine phosphatase PstP 24356 pstP 6224546 pstP Mycobacterium marinum M serine/threonine phosphatase PstP YP_001848346.1 22797 R 216594 CDS YP_001848347.1 183980056 6224547 complement(24353..24820) 1 NC_010612.1 hypothetical protein 24820 6224547 MMAR_0021 Mycobacterium marinum M hypothetical protein YP_001848347.1 24353 R 216594 CDS YP_001848348.1 183980057 6224548 complement(24954..26594) 1 NC_010612.1 function unknown, contains FHA domain; hypothetical protein 26594 6224548 MMAR_0022 Mycobacterium marinum M hypothetical protein YP_001848348.1 24954 R 216594 CDS YP_001848349.1 183980058 6224550 27392..27772 1 NC_010612.1 some domain conservation with a putative killer suppression protein HigA, from Methylococcus capsulatus str. Bath; killer suppression protein 27772 6224550 MMAR_0023 Mycobacterium marinum M killer suppression protein YP_001848349.1 27392 D 216594 CDS YP_001848350.1 183980059 6224551 27769..28845 1 NC_010612.1 antidote for potential plasmid segregant killing system. maybe the partner for the toxin encoded by the upstream gene; plasmid maintenance system antidote protein 28845 6224551 MMAR_0024 Mycobacterium marinum M plasmid maintenance system antidote protein YP_001848350.1 27769 D 216594 CDS YP_001848351.1 183980060 6224552 complement(28826..29764) 1 NC_010612.1 hypothetical protein 29764 6224552 MMAR_0025 Mycobacterium marinum M hypothetical protein YP_001848351.1 28826 R 216594 CDS YP_001848352.1 183980061 6224553 complement(29745..30536) 1 NC_010612.1 hypothetical protein 30536 6224553 MMAR_0026 Mycobacterium marinum M hypothetical protein YP_001848352.1 29745 R 216594 CDS YP_001848353.1 183980062 6224554 complement(30550..31500) 1 NC_010612.1 involved in deoxyribonucleotide biosynthesis. provides the sole de novo source of dTMP for dana biosynthesis [catalytic activity: 5,10- methylenetetrahydrofolate + dump = dihydrofolate + dTMP]; thymidylate synthase, ThyA 31500 thyA_1 6224554 thyA_1 Mycobacterium marinum M thymidylate synthase, ThyA YP_001848353.1 30550 R 216594 CDS YP_001848354.1 183980063 6224555 complement(31578..31934) 1 NC_010612.1 hypothetical protein 31934 6224555 MMAR_0028 Mycobacterium marinum M hypothetical protein YP_001848354.1 31578 R 216594 CDS YP_001848355.1 183980064 6224556 complement(31934..32410) 1 NC_010612.1 hypothetical protein 32410 6224556 MMAR_0029 Mycobacterium marinum M hypothetical protein YP_001848355.1 31934 R 216594 CDS YP_001848356.1 183980065 6224557 complement(33374..34174) 1 NC_010612.1 short-chain dehydrogenase 34174 6224557 MMAR_0030 Mycobacterium marinum M short-chain dehydrogenase YP_001848356.1 33374 R 216594 CDS YP_001848357.1 183980066 6224558 34328..35080 1 NC_010612.1 hypothetical protein 35080 6224558 MMAR_0031 Mycobacterium marinum M hypothetical protein YP_001848357.1 34328 D 216594 CDS YP_001848358.1 183980067 6224559 complement(35105..36100) 1 NC_010612.1 hypothetical protein 36100 6224559 MMAR_0032 Mycobacterium marinum M hypothetical protein YP_001848358.1 35105 R 216594 CDS YP_001848359.1 183980068 6224251 complement(36106..36915) 1 NC_010612.1 hypothetical protein 36915 6224251 MMAR_0033 Mycobacterium marinum M hypothetical protein YP_001848359.1 36106 R 216594 CDS YP_001848360.1 183980069 6224252 complement(36912..38111) 1 NC_010612.1 thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for energy coupling to the transport system; osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter ProV 38111 proV_1 6224252 proV_1 Mycobacterium marinum M osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter ProV YP_001848360.1 36912 R 216594 CDS YP_001848361.1 183980070 6224253 complement(38104..38772) 1 NC_010612.1 maybe involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for the translocation of the substrate across the membrane; ABC transporter permease 38772 6224253 MMAR_0035 Mycobacterium marinum M ABC transporter permease YP_001848361.1 38104 R 216594 CDS YP_001848362.1 183980071 6224254 39071..39478 1 NC_010612.1 DNA-binding protein 39478 6224254 MMAR_0036 Mycobacterium marinum M DNA-binding protein YP_001848362.1 39071 D 216594 CDS YP_001848363.1 183980072 6224255 complement(39580..40539) 1 NC_010612.1 hypothetical protein 40539 6224255 MMAR_0037 Mycobacterium marinum M hypothetical protein YP_001848363.1 39580 R 216594 CDS YP_001848364.1 183980073 6224256 40669..41982 1 NC_010612.1 thought to be involved in transport of ammonium across the membrane (export). responsible for the translocation of the substrate across the membrane; ammonium-transport integral membrane protein, Amt 41982 amt_1 6224256 amt_1 Mycobacterium marinum M ammonium-transport integral membrane protein, Amt YP_001848364.1 40669 D 216594 CDS YP_001848365.1 183980074 6224257 complement(41992..42291) 1 NC_010612.1 hypothetical protein 42291 6224257 MMAR_0039 Mycobacterium marinum M hypothetical protein YP_001848365.1 41992 R 216594 CDS YP_001848366.1 183980075 6224258 complement(42288..43256) 1 NC_010612.1 N-term truncated by frame-shift mutation; hypothetical protein 43256 6224258 MMAR_0040 Mycobacterium marinum M hypothetical protein YP_001848366.1 42288 R 216594 CDS YP_001848367.1 183980076 6224259 complement(43370..43786) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein (Whib-like), WhiB5 43786 whiB5 6224259 whiB5 Mycobacterium marinum M transcriptional regulatory protein (Whib-like), WhiB5 YP_001848367.1 43370 R 216594 CDS YP_001848368.1 183980077 6224260 43930..44721 1 NC_010612.1 maybe involved in transcriptional mechanism; transcriptional regulatory protein 44721 6224260 MMAR_0042 Mycobacterium marinum M transcriptional regulatory protein YP_001848368.1 43930 D 216594 CDS YP_001848369.1 183980078 6224261 44718..45545 1 NC_010612.1 function unknown. the P60 protein is a major extracellular protein may be involved in the invasion of host cells; secreted protein P60-related protein 45545 6224261 MMAR_0043 Mycobacterium marinum M secreted protein P60-related protein YP_001848369.1 44718 D 216594 CDS YP_001848370.1 183980079 6224262 45542..45922 1 NC_010612.1 hypothetical protein 45922 6224262 MMAR_0044 Mycobacterium marinum M hypothetical protein YP_001848370.1 45542 D 216594 CDS YP_001848371.1 183980080 6224263 45997..47250 1 NC_010612.1 hypothetical protein 47250 6224263 MMAR_0045 Mycobacterium marinum M hypothetical protein YP_001848371.1 45997 D 216594 CDS YP_001848372.1 183980081 6224264 47293..47610 1 NC_010612.1 hypothetical protein 47610 6224264 MMAR_0046 Mycobacterium marinum M hypothetical protein YP_001848372.1 47293 D 216594 CDS YP_001848373.1 183980082 6224265 47607..47912 1 NC_010612.1 hypothetical protein 47912 6224265 MMAR_0047 Mycobacterium marinum M hypothetical protein YP_001848373.1 47607 D 216594 CDS YP_001848374.1 183980083 6224266 48140..49246 1 NC_010612.1 hypothetical protein 49246 6224266 MMAR_0048 Mycobacterium marinum M hypothetical protein YP_001848374.1 48140 D 216594 CDS YP_001848375.1 183980084 6224267 49334..49654 1 NC_010612.1 hypothetical protein 49654 6224267 MMAR_0049 Mycobacterium marinum M hypothetical protein YP_001848375.1 49334 D 216594 CDS YP_001848376.1 183980085 6224268 49704..50027 1 NC_010612.1 hypothetical protein 50027 6224268 MMAR_0050 Mycobacterium marinum M hypothetical protein YP_001848376.1 49704 D 216594 CDS YP_001848377.1 183980086 6224269 complement(50055..50828) 1 NC_010612.1 hypothetical protein 50828 6224269 MMAR_0051 Mycobacterium marinum M hypothetical protein YP_001848377.1 50055 R 216594 CDS YP_001848378.1 183980087 6224270 complement(50831..52123) 1 NC_010612.1 integral membrane protein 52123 6224270 MMAR_0052 Mycobacterium marinum M integral membrane protein YP_001848378.1 50831 R 216594 CDS YP_001848379.1 183980088 6224271 52283..52888 1 NC_010612.1 hypothetical protein 52888 6224271 MMAR_0053 Mycobacterium marinum M hypothetical protein YP_001848379.1 52283 D 216594 CDS YP_001848380.1 183980089 6224272 complement(52875..53882) 1 NC_010612.1 hypothetical protein 53882 6224272 MMAR_0054 Mycobacterium marinum M hypothetical protein YP_001848380.1 52875 R 216594 CDS YP_001848381.1 183980090 6224273 complement(53923..54273) 1 NC_010612.1 hypothetical protein 54273 6224273 MMAR_0055 Mycobacterium marinum M hypothetical protein YP_001848381.1 53923 R 216594 CDS YP_001848382.1 183980091 6224274 complement(54358..55491) 1 NC_010612.1 secreted proline rich protein Mtc28 55491 mtc28 6224274 mtc28 Mycobacterium marinum M secreted proline rich protein Mtc28 YP_001848382.1 54358 R 216594 CDS YP_001848383.1 183980092 6224275 55690..58620 1 NC_010612.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 58620 leuS 6224275 leuS Mycobacterium marinum M leucyl-tRNA synthetase YP_001848383.1 55690 D 216594 CDS YP_001848384.1 183980093 6224276 complement(58650..59315) 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short chain dehydrogenase 59315 6224276 MMAR_0058 Mycobacterium marinum M short chain dehydrogenase YP_001848384.1 58650 R 216594 CDS YP_001848385.1 183980094 6224277 complement(59356..59859) 1 NC_010612.1 possibly involved in transcriptional mechanism; transcriptional regulatory protein 59859 6224277 MMAR_0059 Mycobacterium marinum M transcriptional regulatory protein YP_001848385.1 59356 R 216594 CDS YP_001848386.1 183980095 6224278 complement(59916..60665) 1 NC_010612.1 involved in amino acid transport and metabolism; glutamine ABC transporter ATP-binding protein 60665 6224278 MMAR_0060 Mycobacterium marinum M glutamine ABC transporter ATP-binding protein YP_001848386.1 59916 R 216594 CDS YP_001848387.1 183980096 6224279 complement(60662..62431) 1 NC_010612.1 amino acid transport and metabolism; ABC transporter permease GlnQ 62431 glnQ 6224279 glnQ Mycobacterium marinum M ABC transporter permease GlnQ YP_001848387.1 60662 R 216594 CDS YP_001848388.1 183980097 6224280 complement(62513..63277) 1 NC_010612.1 involved in transcriptional mechanism; GntR family transcriptional regulator 63277 6224280 MMAR_0062 Mycobacterium marinum M GntR family transcriptional regulator YP_001848388.1 62513 R 216594 CDS YP_001848389.1 183980098 6224281 complement(63388..64185) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 64185 6224281 MMAR_0063 Mycobacterium marinum M oxidoreductase YP_001848389.1 63388 R 216594 CDS YP_001848390.1 183980099 6224282 complement(64217..65131) 1 NC_010612.1 function unknown, probably involved in lipid biosynthesis; hydrolase 65131 6224282 MMAR_0064 Mycobacterium marinum M hydrolase YP_001848390.1 64217 R 216594 CDS YP_001848391.1 183980100 6224283 complement(65222..66340) 1 NC_010612.1 involved in phosphatidylinositol (pi) biosynthetic pathway [catalytic activity: d-glucose 6-phosphate = 1L- myo-inositol 1-phosphate]; myo-inositol-1-phosphate synthase Ino1 66340 ino1 6224283 ino1 Mycobacterium marinum M myo-inositol-1-phosphate synthase Ino1 YP_001848391.1 65222 R 216594 CDS YP_001848392.1 183980101 6224284 complement(66402..66944) 1 NC_010612.1 hypothetical protein 66944 6224284 MMAR_0066 Mycobacterium marinum M hypothetical protein YP_001848392.1 66402 R 216594 CDS YP_001848393.1 183980102 6224285 complement(67100..67969) 1 NC_010612.1 hypothetical protein 67969 6224285 MMAR_0067 Mycobacterium marinum M hypothetical protein YP_001848393.1 67100 R 216594 CDS YP_001848394.1 183980103 6224286 68082..68516 1 NC_010612.1 hypothetical protein 68516 6224286 MMAR_0068 Mycobacterium marinum M hypothetical protein YP_001848394.1 68082 D 216594 CDS YP_001848395.1 183980104 6224287 68974..71046 1 NC_010612.1 involved in peptidoglycan synthesis (at the final stages), cell wall formation. synthesis of cross-linked peptidoglycan from the lipid intermediates. the enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits); bifunctional penicillin-binding protein 1A/1B PonA1 71046 ponA1 6224287 ponA1 Mycobacterium marinum M bifunctional penicillin-binding protein 1A/1B PonA1 YP_001848395.1 68974 D 216594 CDS YP_001848396.1 183980105 6224288 71043..72683 1 NC_010612.1 hypothetical protein 72683 6224288 MMAR_0070 Mycobacterium marinum M hypothetical protein YP_001848396.1 71043 D 216594 CDS YP_001848397.1 183980106 6224289 72683..73321 1 NC_010612.1 transcriptional regulatory protein 73321 6224289 MMAR_0071 Mycobacterium marinum M transcriptional regulatory protein YP_001848397.1 72683 D 216594 CDS YP_001848398.1 183980107 6224290 73445..73735 1 NC_010612.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 73735 rpsF 6224290 rpsF Mycobacterium marinum M 30S ribosomal protein S6 YP_001848398.1 73445 D 216594 CDS YP_001848399.1 183980108 6224291 73827..74354 1 NC_010612.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 74354 ssb 6224291 ssb Mycobacterium marinum M single-stranded DNA-binding protein YP_001848399.1 73827 D 216594 CDS YP_001848400.1 183980109 6224292 74400..74654 1 NC_010612.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 74654 rpsR 6224292 rpsR Mycobacterium marinum M 30S ribosomal protein S18 YP_001848400.1 74400 D 216594 CDS YP_001848401.1 183980110 6224293 74697..75155 1 NC_010612.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 75155 rplI 6224293 rplI Mycobacterium marinum M 50S ribosomal protein L9 YP_001848401.1 74697 D 216594 CDS YP_001848402.1 183980111 6224294 75689..77071 1 NC_010612.1 participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity; replicative DNA helicase DnaB 77071 dnaB 6224294 dnaB Mycobacterium marinum M replicative DNA helicase DnaB YP_001848402.1 75689 D 216594 CDS YP_001848403.1 183980112 6224295 77176..77604 1 NC_010612.1 hypothetical protein 77604 6224295 MMAR_0077 Mycobacterium marinum M hypothetical protein YP_001848403.1 77176 D 216594 CDS YP_001848404.1 183980113 6224296 77847..78095 1 NC_010612.1 hypothetical protein 78095 6224296 MMAR_0078 Mycobacterium marinum M hypothetical protein YP_001848404.1 77847 D 216594 CDS YP_001848405.1 183980114 6224297 78147..78350 1 NC_010612.1 hypothetical protein 78350 6224297 MMAR_0079 Mycobacterium marinum M hypothetical protein YP_001848405.1 78147 D 216594 CDS YP_001848406.1 183980115 6224298 complement(78908..81016) 1 NC_010612.1 involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase large chain CoxL_2 81016 coxL_2 6224298 coxL_2 Mycobacterium marinum M carbon monoxyde dehydrogenase large chain CoxL_2 YP_001848406.1 78908 R 216594 CDS YP_001848407.1 183980116 6224299 complement(81013..82017) 1 NC_010612.1 function unknown; probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase medium chain CoxM_2 82017 coxM_2 6224299 coxM_2 Mycobacterium marinum M carbon monoxyde dehydrogenase medium chain CoxM_2 YP_001848407.1 81013 R 216594 CDS YP_001848408.1 183980117 6224300 complement(82014..82523) 1 NC_010612.1 involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase small chain CoxS_2 82523 coxS_2 6224300 coxS_2 Mycobacterium marinum M carbon monoxyde dehydrogenase small chain CoxS_2 YP_001848408.1 82014 R 216594 CDS YP_001848409.1 183980118 6224301 complement(82520..83431) 1 NC_010612.1 amidohydrolase 83431 6224301 MMAR_0083 Mycobacterium marinum M amidohydrolase YP_001848409.1 82520 R 216594 CDS YP_001848410.1 183980119 6224302 84174..84782 1 NC_010612.1 function unknown; probably involved in cellular metabolism; short chain dehydrogenase 84782 6224302 MMAR_0084 Mycobacterium marinum M short chain dehydrogenase YP_001848410.1 84174 D 216594 CDS YP_001848411.1 183980120 6224303 84893..87637 1 NC_010612.1 contains N-term ATPase domain and C-term DNA- binding domain; may be involved in regulation of transcription; transcriptional regulatory protein 87637 6224303 MMAR_0085 Mycobacterium marinum M transcriptional regulatory protein YP_001848411.1 84893 D 216594 CDS YP_001848412.1 183980121 6224304 complement(88106..88885) 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; hydrolase 88885 6224304 MMAR_0086 Mycobacterium marinum M hydrolase YP_001848412.1 88106 R 216594 CDS YP_001848413.1 183980122 6224305 88976..90742 1 NC_010612.1 Contains a non-ribosomal peptide synthetase-like condensation domain; hypothetical protein 90742 6224305 MMAR_0087 Mycobacterium marinum M hypothetical protein YP_001848413.1 88976 D 216594 CDS YP_001848414.1 183980123 6224306 complement(90890..91492) 1 NC_010612.1 transcriptional regulator 91492 6224306 MMAR_0088 Mycobacterium marinum M transcriptional regulator YP_001848414.1 90890 R 216594 CDS YP_001848415.1 183980124 6224307 91634..92122 1 NC_010612.1 function unknown; contains thiopurine S- methyltransferase domain. this is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulfhydryl compounds; hypothetical protein 92122 6224307 MMAR_0089 Mycobacterium marinum M hypothetical protein YP_001848415.1 91634 D 216594 CDS YP_001848416.1 183980125 6224308 complement(92022..92816) 1 NC_010612.1 transposition of the insertion sequence, ISMyma01; transposase, ISMyma01_aa2 92816 6224308 MMAR_0090 Mycobacterium marinum M transposase, ISMyma01_aa2 YP_001848416.1 92022 R 216594 CDS YP_001848417.1 183980126 6224309 complement(92858..93139) 1 NC_010612.1 transposition of the insertion sequence, ISMyma01; transposase, ISMyma01_aa1 93139 6224309 MMAR_0091 Mycobacterium marinum M transposase, ISMyma01_aa1 YP_001848417.1 92858 R 216594 CDS YP_001848418.1 183980127 6224310 93232..93537 1 NC_010612.1 hypothetical protein 93537 6224310 MMAR_0092 Mycobacterium marinum M hypothetical protein YP_001848418.1 93232 D 216594 CDS YP_001848419.1 183980128 6224311 complement(93566..95239) 1 NC_010612.1 translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; integral membrane efflux protein ErmB 95239 ermB 6224311 ermB Mycobacterium marinum M integral membrane efflux protein ErmB YP_001848419.1 93566 R 216594 CDS YP_001848420.1 183980129 6224312 complement(95329..98193) 1 NC_010612.1 thought to be involved in fatty acid transport; transmembrane transport protein MmpL 98193 mmpL5_3 6224312 mmpL5_3 Mycobacterium marinum M transmembrane transport protein MmpL YP_001848420.1 95329 R 216594 CDS YP_001848421.1 183980130 6224313 complement(98190..98627) 1 NC_010612.1 membrane protein MmpS5_3 98627 mmpS5_3 6224313 mmpS5_3 Mycobacterium marinum M membrane protein MmpS5_3 YP_001848421.1 98190 R 216594 CDS YP_001848422.1 183980131 6224314 99141..99527 1 NC_010612.1 hypothetical protein 99527 6224314 MMAR_0096 Mycobacterium marinum M hypothetical protein YP_001848422.1 99141 D 216594 CDS YP_001848423.1 183980132 6224315 99527..99763 1 NC_010612.1 function unknown; many of the members of this family are found in known antibiotic synthesis gene clusters; MbtH-like protein 99763 6224315 MMAR_0097 Mycobacterium marinum M MbtH-like protein YP_001848423.1 99527 D 216594 CDS YP_001848424.1 183980133 6224316 99926..103084 1 NC_010612.1 polyketide synthase possibly involved in lipid synthesis; polyketide synthase 103084 6224316 MMAR_0098 Mycobacterium marinum M polyketide synthase YP_001848424.1 99926 D 216594 CDS YP_001848425.1 183980134 6224317 103081..114750 1 NC_010612.1 function unknown but the gene encodes a Nrp of three functional domains with the predicted sequential condensation of the amino acids threonine, threonine and alanine. the second domain contains an epimerization domain and the third domains contains a terminal te; non-ribosomal peptide synthetase 114750 6224317 MMAR_0099 Mycobacterium marinum M non-ribosomal peptide synthetase YP_001848425.1 103081 D 216594 CDS YP_001848426.1 183980135 6224318 114798..115397 1 NC_010612.1 4-hydroxybenzoate synthetase 115397 6224318 MMAR_0100 Mycobacterium marinum M 4-hydroxybenzoate synthetase YP_001848426.1 114798 D 216594 CDS YP_001848427.1 183980136 6224319 115545..122879 1 NC_010612.1 function unknown but contains a single extension module with domain structure (KS, Ata, DH, KR, ACP); polyketide synthase 122879 6224319 MMAR_0101 Mycobacterium marinum M polyketide synthase YP_001848427.1 115545 D 216594 CDS YP_001848428.1 183980137 6224320 122876..129469 1 NC_010612.1 function unknown but contains a single extension module with domain structure (KS, ATP, DH, ER, ACP); polyketide synthase 129469 6224320 MMAR_0102 Mycobacterium marinum M polyketide synthase YP_001848428.1 122876 D 216594 CDS YP_001848429.1 183980138 6224321 129487..130578 1 NC_010612.1 hypothetical protein 130578 6224321 MMAR_0103 Mycobacterium marinum M hypothetical protein YP_001848429.1 129487 D 216594 CDS YP_001848430.1 183980139 6224322 130639..132027 1 NC_010612.1 function unknown but probable role in the production of unknown PKS/NRP metabolite from this locus. amino acid homology suggests this gene product may have fatty acid ligase activity; hypothetical protein 132027 6224322 MMAR_0104 Mycobacterium marinum M hypothetical protein YP_001848430.1 130639 D 216594 CDS YP_001848431.1 183980140 6224323 complement(132134..132397) 1 NC_010612.1 hypothetical protein 132397 6224323 MMAR_0105 Mycobacterium marinum M hypothetical protein YP_001848431.1 132134 R 216594 CDS YP_001848432.1 183980141 6224324 complement(132604..133635) 1 NC_010612.1 contains two MaoC acyl dehydratase domains; hypothetical protein 133635 6224324 MMAR_0106 Mycobacterium marinum M hypothetical protein YP_001848432.1 132604 R 216594 CDS YP_001848433.1 183980142 6224325 133857..134909 1 NC_010612.1 hydrolysis of cellobiose; cellobiohydrolase a (1,4-beta-cellobiosidase a) CelA 134909 celA 6224325 celA Mycobacterium marinum M cellobiohydrolase a (1,4-beta-cellobiosidase a) CelA YP_001848433.1 133857 D 216594 CDS YP_001848434.1 183980143 6224326 135051..135656 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 135656 6224326 MMAR_0108 Mycobacterium marinum M transcriptional regulatory protein YP_001848434.1 135051 D 216594 CDS YP_001848435.1 183980144 6224327 135771..136856 1 NC_010612.1 hypothetical protein 136856 6224327 MMAR_0109 Mycobacterium marinum M hypothetical protein YP_001848435.1 135771 D 216594 CDS YP_001848436.1 183980145 6224328 137017..138456 1 NC_010612.1 function unknown; probably involved in cellular metabolism; oxidoreductase 138456 6224328 MMAR_0110 Mycobacterium marinum M oxidoreductase YP_001848436.1 137017 D 216594 CDS YP_001848437.1 183980146 6224329 complement(138493..139467) 1 NC_010612.1 PE family protein 139467 6224329 MMAR_0111 Mycobacterium marinum M PE family protein YP_001848437.1 138493 R 216594 CDS YP_001848438.1 183980147 6224330 139721..140698 1 NC_010612.1 catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide; haloalkane dehalogenase 140698 dhaA_1 6224330 dhaA_1 Mycobacterium marinum M haloalkane dehalogenase YP_001848438.1 139721 D 216594 CDS YP_001848439.1 183980148 6224331 complement(140862..141167) 1 NC_010612.1 hypothetical protein 141167 6224331 MMAR_0113 Mycobacterium marinum M hypothetical protein YP_001848439.1 140862 R 216594 CDS YP_001848440.1 183980149 6224332 complement(141538..141798) 1 NC_010612.1 hypothetical protein 141798 6224332 MMAR_0115 Mycobacterium marinum M hypothetical protein YP_001848440.1 141538 R 216594 CDS YP_001848441.1 183980150 6224333 complement(141795..142814) 1 NC_010612.1 hypothetical protein 142814 6224333 MMAR_0116 Mycobacterium marinum M hypothetical protein YP_001848441.1 141795 R 216594 CDS YP_001848442.1 183980151 6224334 complement(142815..143285) 1 NC_010612.1 hypothetical protein 143285 6224334 MMAR_0117 Mycobacterium marinum M hypothetical protein YP_001848442.1 142815 R 216594 CDS YP_001848443.1 183980152 6224335 complement(143631..144206) 1 NC_010612.1 regulatory protein 144206 6224335 MMAR_0118 Mycobacterium marinum M regulatory protein YP_001848443.1 143631 R 216594 CDS YP_001848444.1 183980153 6224336 144293..145480 1 NC_010612.1 function unknown but some domain identity with nitroreductase-related proteins; hypothetical protein 145480 6224336 MMAR_0119 Mycobacterium marinum M hypothetical protein YP_001848444.1 144293 D 216594 CDS YP_001848445.1 183980154 6224337 145613..147001 1 NC_010612.1 function unknown but contains C-term predicted ATPase domain (AAA+ superfamily); hypothetical protein 147001 6224337 MMAR_0120 Mycobacterium marinum M hypothetical protein YP_001848445.1 145613 D 216594 CDS YP_001848446.1 183980155 6224338 147163..149505 1 NC_010612.1 decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors [catalytic activity: formate + NAD(+) = CO(2) + NADH]; formate dehydrogenase H 149505 6224338 MMAR_0121 Mycobacterium marinum M formate dehydrogenase H YP_001848446.1 147163 D 216594 CDS YP_001848447.1 183980156 6224339 complement(149522..150760) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 279A2 Cyp279A2 150760 cyp279A2 6224339 cyp279A2 Mycobacterium marinum M cytochrome P450 279A2 Cyp279A2 YP_001848447.1 149522 R 216594 CDS YP_001848448.1 183980157 6224340 150923..154276 1 NC_010612.1 involved in transcriptional mechanism; LuxR family transcriptional regulator 154276 6224340 MMAR_0123 Mycobacterium marinum M LuxR family transcriptional regulator YP_001848448.1 150923 D 216594 CDS YP_001848449.1 183980158 6224341 complement(154332..155273) 1 NC_010612.1 possibly binds NADP and acts through a one-electron transfer process. quinones are supposed to be the best substrates. may act in the detoxification of xenobiotics [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone oxidoreductase 155273 6224341 MMAR_0124 Mycobacterium marinum M quinone oxidoreductase YP_001848449.1 154332 R 216594 CDS YP_001848450.1 183980159 6224342 155386..155832 1 NC_010612.1 MarR family transcriptional regulator 155832 6224342 MMAR_0125 Mycobacterium marinum M MarR family transcriptional regulator YP_001848450.1 155386 D 216594 CDS YP_001848451.1 183980160 6224343 complement(155864..156622) 1 NC_010612.1 hypothetical protein 156622 6224343 MMAR_0126 Mycobacterium marinum M hypothetical protein YP_001848451.1 155864 R 216594 CDS YP_001848452.1 183980161 6224344 complement(156692..157801) 1 NC_010612.1 thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]; zinc-containing alcohol dehydrogenase NAD- dependent, AdhD 157801 adhD_1 6224344 adhD_1 Mycobacterium marinum M zinc-containing alcohol dehydrogenase NAD- dependent, AdhD YP_001848452.1 156692 R 216594 CDS YP_001848453.1 183980162 6224345 complement(157936..158958) 1 NC_010612.1 function unknown; may be involved in electron transfer; oxidoreductase 158958 6224345 MMAR_0128 Mycobacterium marinum M oxidoreductase YP_001848453.1 157936 R 216594 CDS YP_001848454.1 183980163 6224346 complement(158967..159284) 1 NC_010612.1 function unknown, but the MmoB/DmpM family consists of monooxygenase components such as MmoB methane monooxygenase regulatory protein B. When MmoB is present at low concentration it converts methane monooxygenase from an oxidase to a hydroxylase and stabilises intermediates required for the activation of dioxygen; monooxygenase effector, MmoB/DmpM family protein 159284 6224346 MMAR_0129 Mycobacterium marinum M monooxygenase effector, MmoB/DmpM family protein YP_001848454.1 158967 R 216594 CDS YP_001848455.1 183980164 6224347 complement(159281..160372) 1 NC_010612.1 function unknown, but enzymes in this family are involved in hydroxylation of hydrocarbons; monooxygenase hydroxylase, subunit B 160372 6224347 MMAR_0130 Mycobacterium marinum M monooxygenase hydroxylase, subunit B YP_001848455.1 159281 R 216594 CDS YP_001848456.1 183980165 6224348 complement(160372..161910) 1 NC_010612.1 Enzymes in this family are involved in hydroxylation of hydrocarbons; monooxygenase hydroxylase, subunit A 161910 6224348 MMAR_0131 Mycobacterium marinum M monooxygenase hydroxylase, subunit A YP_001848456.1 160372 R 216594 CDS YP_001848457.1 183980166 6224349 162067..162729 1 NC_010612.1 response regulator of a two-component regulatory system involved in transcriptional regulatory mechanism. has domain homology to CitB, a response regulator containing a CheY-like receiver domain and an HTH DNA- binding domain; two-component transcriptional regulatory protein 162729 6224349 MMAR_0132 Mycobacterium marinum M two-component transcriptional regulatory protein YP_001848457.1 162067 D 216594 CDS YP_001848458.1 183980167 6224350 complement(162701..163795) 1 NC_010612.1 sensor part of the two-component regulatory system; two-component sensor histidine kinase 163795 6224350 MMAR_0133 Mycobacterium marinum M two-component sensor histidine kinase YP_001848458.1 162701 R 216594 CDS YP_001848459.1 183980168 6224351 164203..164562 1 NC_010612.1 hypothetical protein 164562 6224351 MMAR_0134 Mycobacterium marinum M hypothetical protein YP_001848459.1 164203 D 216594 CDS YP_001848460.1 183980169 6224352 164572..165291 1 NC_010612.1 hypothetical protein 165291 6224352 MMAR_0135 Mycobacterium marinum M hypothetical protein YP_001848460.1 164572 D 216594 CDS YP_001848461.1 183980170 6224353 165450..166634 1 NC_010612.1 intergral membrane protein 166634 6224353 MMAR_0136 Mycobacterium marinum M intergral membrane protein YP_001848461.1 165450 D 216594 CDS YP_001848462.1 183980171 6224354 166686..166952 1 NC_010612.1 hypothetical protein 166952 6224354 MMAR_0137 Mycobacterium marinum M hypothetical protein YP_001848462.1 166686 D 216594 CDS YP_001848463.1 183980172 6224355 complement(166992..168185) 1 NC_010612.1 hypothetical protein 168185 6224355 MMAR_0138 Mycobacterium marinum M hypothetical protein YP_001848463.1 166992 R 216594 CDS YP_001848464.1 183980173 6224356 complement(168341..170566) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE6 170566 fadE6_1 6224356 fadE6_1 Mycobacterium marinum M acyl-CoA dehydrogenase FadE6 YP_001848464.1 168341 R 216594 CDS YP_001848465.1 183980174 6224357 complement(170574..171440) 1 NC_010612.1 hypothetical protein 171440 6224357 MMAR_0140 Mycobacterium marinum M hypothetical protein YP_001848465.1 170574 R 216594 CDS YP_001848466.1 183980175 6224358 171755..172330 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 172330 6224358 MMAR_0141 Mycobacterium marinum M TetR family transcriptional regulator YP_001848466.1 171755 D 216594 CDS YP_001848467.1 183980176 6224359 complement(172339..173550) 1 NC_010612.1 possibly catalyzes the transfer of a great variety of lipids between membranes; lipid-transfer protein Ltp1 173550 ltp1_1 6224359 ltp1_1 Mycobacterium marinum M lipid-transfer protein Ltp1 YP_001848467.1 172339 R 216594 CDS YP_001848468.1 183980177 6224360 complement(173581..173979) 1 NC_010612.1 hypothetical protein 173979 6224360 MMAR_0143 Mycobacterium marinum M hypothetical protein YP_001848468.1 173581 R 216594 CDS YP_001848469.1 183980178 6224361 complement(174075..174491) 1 NC_010612.1 hypothetical protein 174491 6224361 MMAR_0144 Mycobacterium marinum M hypothetical protein YP_001848469.1 174075 R 216594 CDS YP_001848470.1 183980179 6224362 complement(174522..175013) 1 NC_010612.1 transcriptional regulator 175013 6224362 MMAR_0145 Mycobacterium marinum M transcriptional regulator YP_001848470.1 174522 R 216594 CDS YP_001848471.1 183980180 6224363 175147..176310 1 NC_010612.1 ATPase 176310 6224363 MMAR_0146 Mycobacterium marinum M ATPase YP_001848471.1 175147 D 216594 CDS YP_001848472.1 183980181 6224364 complement(176332..177075) 1 NC_010612.1 function unknown; hypothetical protein 177075 6224364 MMAR_0147 Mycobacterium marinum M hypothetical protein YP_001848472.1 176332 R 216594 CDS YP_001848473.1 183980182 6224365 complement(177130..178338) 1 NC_010612.1 function unknown, glycosyltransferases, related to UDP-glucuronosyltransferase; glycosyltransferase 178338 6224365 MMAR_0148 Mycobacterium marinum M glycosyltransferase YP_001848473.1 177130 R 216594 CDS YP_001848474.1 183980183 6224366 complement(178407..179618) 1 NC_010612.1 function unknown, but involved in lipid degradation [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF]; acyl-CoA dehydrogenase FadE25_2 179618 fadE25_2 6224366 fadE25_2 Mycobacterium marinum M acyl-CoA dehydrogenase FadE25_2 YP_001848474.1 178407 R 216594 CDS YP_001848475.1 183980184 6224367 complement(179647..180291) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 180291 6224367 MMAR_0150 Mycobacterium marinum M TetR family transcriptional regulator YP_001848475.1 179647 R 216594 CDS YP_001848476.1 183980185 6224368 complement(180345..181562) 1 NC_010612.1 supposed involved in intracellular survival. possibly associated with the cell surface and secreted; hypothetical protein 181562 eis1 6224368 eis1 Mycobacterium marinum M hypothetical protein YP_001848476.1 180345 R 216594 CDS YP_001848477.1 183980186 6224369 complement(181702..182268) 1 NC_010612.1 hypothetical protein 182268 6224369 MMAR_0152 Mycobacterium marinum M hypothetical protein YP_001848477.1 181702 R 216594 CDS YP_001848478.1 183980187 6224370 182396..182827 1 NC_010612.1 hypothetical protein 182827 6224370 MMAR_0153 Mycobacterium marinum M hypothetical protein YP_001848478.1 182396 D 216594 CDS YP_001848479.1 183980188 6224371 182886..183926 1 NC_010612.1 function unknown, probably involved in cellular metabolism; coenzyme F420-dependent oxidoreductase 183926 6224371 MMAR_0154 Mycobacterium marinum M coenzyme F420-dependent oxidoreductase YP_001848479.1 182886 D 216594 CDS YP_001848480.1 183980189 6224372 complement(183948..185015) 1 NC_010612.1 function unknown, but possibly involvement in lipid degradation; acyl-CoA dehydrogenase FadE36 185015 fadE36_1 6224372 fadE36_1 Mycobacterium marinum M acyl-CoA dehydrogenase FadE36 YP_001848480.1 183948 R 216594 CDS YP_001848481.1 183980190 6224373 complement(185034..186257) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE2 186257 fadE2_1 6224373 fadE2_1 Mycobacterium marinum M acyl-CoA dehydrogenase FadE2 YP_001848481.1 185034 R 216594 CDS YP_001848482.1 183980191 6224374 complement(186380..187504) 1 NC_010612.1 possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]; adenylate cyclase CyaA 187504 cyaA 6224374 cyaA Mycobacterium marinum M adenylate cyclase CyaA YP_001848482.1 186380 R 216594 CDS YP_001848483.1 183980192 6224375 complement(187618..189855) 1 NC_010612.1 involved in the krebs cycle [catalytic activity: isocitrate + NADP+ = 2-oxoglutarate + CO(2) + NADPH]; isocitrate dehydrogenase [NADP] Icd2 189855 icd2 6224375 icd2 Mycobacterium marinum M isocitrate dehydrogenase [NADP] Icd2 YP_001848483.1 187618 R 216594 CDS YP_001848484.1 183980193 6224376 complement(190532..191368) 1 NC_010612.1 hypothetical protein 191368 6224376 MMAR_0159 Mycobacterium marinum M hypothetical protein YP_001848484.1 190532 R 216594 CDS YP_001848485.1 183980194 6224377 complement(191358..192149) 1 NC_010612.1 function unknown. possibly secreted; hypothetical protein 192149 6224377 MMAR_0160 Mycobacterium marinum M hypothetical protein YP_001848485.1 191358 R 216594 CDS YP_001848486.1 183980195 6224378 complement(192161..192886) 1 NC_010612.1 hypothetical protein 192886 6224378 MMAR_0161 Mycobacterium marinum M hypothetical protein YP_001848486.1 192161 R 216594 CDS YP_001848487.1 183980196 6224379 193261..194349 1 NC_010612.1 hypothetical protein 194349 6224379 MMAR_0162 Mycobacterium marinum M hypothetical protein YP_001848487.1 193261 D 216594 CDS YP_001848488.1 183980197 6224380 194342..195523 1 NC_010612.1 hypothetical protein 195523 6224380 MMAR_0163 Mycobacterium marinum M hypothetical protein YP_001848488.1 194342 D 216594 CDS YP_001848489.1 183980198 6224381 195523..196503 1 NC_010612.1 function unknown, probably involved in cellular metabolism; nucleoside-diphosphate-sugar epimerase 196503 6224381 MMAR_0164 Mycobacterium marinum M nucleoside-diphosphate-sugar epimerase YP_001848489.1 195523 D 216594 CDS YP_001848490.1 183980199 6224382 196500..197597 1 NC_010612.1 function unknown; hypothetical protein 197597 6224382 MMAR_0165 Mycobacterium marinum M hypothetical protein YP_001848490.1 196500 D 216594 CDS YP_001848491.1 183980200 6224383 197597..198946 1 NC_010612.1 4-aminobutyrate aminotransferase 198946 gabT_2 6224383 gabT_2 Mycobacterium marinum M 4-aminobutyrate aminotransferase YP_001848491.1 197597 D 216594 CDS YP_001848492.1 183980201 6224384 198943..200451 1 NC_010612.1 catalyzes the production of GabA [catalytic activity: L-glutamate = 4-aminobutanoate + CO(2)]; glutamate decarboxylase 200451 6224384 MMAR_0167 Mycobacterium marinum M glutamate decarboxylase YP_001848492.1 198943 D 216594 CDS YP_001848493.1 183980202 6224385 200448..201191 1 NC_010612.1 hypothetical protein 201191 6224385 MMAR_0168 Mycobacterium marinum M hypothetical protein YP_001848493.1 200448 D 216594 CDS YP_001848494.1 183980203 6224386 201188..201694 1 NC_010612.1 hypothetical protein 201694 6224386 MMAR_0169 Mycobacterium marinum M hypothetical protein YP_001848494.1 201188 D 216594 CDS YP_001848495.1 183980204 6224387 201706..202434 1 NC_010612.1 hypothetical protein 202434 6224387 MMAR_0170 Mycobacterium marinum M hypothetical protein YP_001848495.1 201706 D 216594 CDS YP_001848496.1 183980205 6224388 202409..203383 1 NC_010612.1 probably involved in active transport of substrate across the membrane (export). responsible for energy coupling to the transport system; ABC transporter ATP-binding protein 203383 6224388 MMAR_0171 Mycobacterium marinum M ABC transporter ATP-binding protein YP_001848496.1 202409 D 216594 CDS YP_001848497.1 183980206 6224389 203380..204156 1 NC_010612.1 hypothetical protein 204156 6224389 MMAR_0172 Mycobacterium marinum M hypothetical protein YP_001848497.1 203380 D 216594 CDS YP_001848498.1 183980207 6224390 204172..204453 1 NC_010612.1 thought to be involved in de novo fatty acid biosynthesis; this protein is the carrier of the growing fatty acid chain in fatty acid biosynthesis; acyl carrier protein 204453 6224390 MMAR_0173 Mycobacterium marinum M acyl carrier protein YP_001848498.1 204172 D 216594 CDS YP_001848499.1 183980208 6224391 204462..206102 1 NC_010612.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 206102 pks16_1 6224391 pks16_1 Mycobacterium marinum M long-chain-fatty-acid--CoA ligase YP_001848499.1 204462 D 216594 CDS YP_001848500.1 183980209 6224392 206112..206957 1 NC_010612.1 integral membrane protein YrbE6A 206957 yrbE6A 6224392 yrbE6A Mycobacterium marinum M integral membrane protein YrbE6A YP_001848500.1 206112 D 216594 CDS YP_001848501.1 183980210 6224393 206959..207825 1 NC_010612.1 integral membrane protein YrbE6B 207825 yrbE6B 6224393 yrbE6B Mycobacterium marinum M integral membrane protein YrbE6B YP_001848501.1 206959 D 216594 CDS YP_001848502.1 183980211 6224394 207828..209318 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce6A 209318 mce6A 6224394 mce6A Mycobacterium marinum M MCE-family protein Mce6A YP_001848502.1 207828 D 216594 CDS YP_001848503.1 183980212 6224395 209337..210410 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce6B 210410 mce6B 6224395 mce6B Mycobacterium marinum M MCE-family protein Mce6B YP_001848503.1 209337 D 216594 CDS YP_001848504.1 183980213 6224396 210403..211449 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce6C 211449 mce6C 6224396 mce6C Mycobacterium marinum M MCE-family protein Mce6C YP_001848504.1 210403 D 216594 CDS YP_001848505.1 183980214 6224397 211446..212558 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce6D 212558 mce6D 6224397 mce6D Mycobacterium marinum M MCE-family protein Mce6D YP_001848505.1 211446 D 216594 CDS YP_001848506.1 183980215 6224398 212555..213682 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE family lipoprotein Mce6E 213682 mce6E 6224398 mce6E Mycobacterium marinum M MCE family lipoprotein Mce6E YP_001848506.1 212555 D 216594 CDS YP_001848507.1 183980216 6224399 213679..214917 1 NC_010612.1 function unknown, but thought involved in host cell invasion; MCE-family protein Mce6F 214917 mce6F 6224399 mce6F Mycobacterium marinum M MCE-family protein Mce6F YP_001848507.1 213679 D 216594 CDS YP_001848508.1 183980217 6224400 215603..218155 1 NC_010612.1 PE-PGRS family protein 218155 6224400 MMAR_0183 Mycobacterium marinum M PE-PGRS family protein YP_001848508.1 215603 D 216594 CDS YP_001848509.1 183980218 6224401 218996..220441 1 NC_010612.1 hypothetical protein 220441 6224401 MMAR_0184 Mycobacterium marinum M hypothetical protein YP_001848509.1 218996 D 216594 CDS YP_001848510.1 183980219 6224402 220525..220821 1 NC_010612.1 PE family protein 220821 6224402 MMAR_0185 Mycobacterium marinum M PE family protein YP_001848510.1 220525 D 216594 CDS YP_001848511.1 183980220 6224403 220878..221984 1 NC_010612.1 PPE family protein 221984 6224403 MMAR_0186 Mycobacterium marinum M PPE family protein YP_001848511.1 220878 D 216594 CDS YP_001848512.1 183980221 6224404 222089..222391 1 NC_010612.1 a culture filtrate antigen that forms part of a novel secretion apparatus; 10 kDa culture filtrate antigen EsxB 222391 esxB_1 6224404 esxB_1 Mycobacterium marinum M 10 kDa culture filtrate antigen EsxB YP_001848512.1 222089 D 216594 CDS YP_001848513.1 183980222 6224405 222428..222715 1 NC_010612.1 6kDA, culture filtrate antigen forms part of a novel secretion apparatus; 6 kDa culture filtrate antigen EsxA 222715 esxA_1 6224405 esxA_1 Mycobacterium marinum M 6 kDa culture filtrate antigen EsxA YP_001848513.1 222428 D 216594 CDS YP_001848514.1 183980223 6224406 222948..223235 1 NC_010612.1 function unknown but identity with other Esx proteins, including EsxA; EsxA-like protein, EsxA_3 223235 esxA_3 6224406 esxA_3 Mycobacterium marinum M EsxA-like protein, EsxA_3 YP_001848514.1 222948 D 216594 CDS YP_001848515.1 183980224 6224407 223485..223664 1 NC_010612.1 hypothetical protein 223664 6224407 MMAR_0190 Mycobacterium marinum M hypothetical protein YP_001848515.1 223485 D 216594 CDS YP_001848516.1 183980225 6224408 223778..224923 1 NC_010612.1 PPE family protein 224923 6224408 MMAR_0191 Mycobacterium marinum M PPE family protein YP_001848516.1 223778 D 216594 CDS YP_001848517.1 183980226 6224409 225330..225551 1 NC_010612.1 hypothetical protein 225551 6224409 MMAR_0193 Mycobacterium marinum M hypothetical protein YP_001848517.1 225330 D 216594 CDS YP_001848518.1 183980227 6224410 225548..225676 1 NC_010612.1 hypothetical protein 225676 6224410 MMAR_0194 Mycobacterium marinum M hypothetical protein YP_001848518.1 225548 D 216594 CDS YP_001848519.1 183980228 6224411 225736..226038 1 NC_010612.1 EsxB-like protein, EsxB_2 226038 esxB_2 6224411 esxB_2 Mycobacterium marinum M EsxB-like protein, EsxB_2 YP_001848519.1 225736 D 216594 CDS YP_001848520.1 183980229 6224412 226072..226359 1 NC_010612.1 EsxA-like protein, EsxA_2 226359 esxA_2 6224412 esxA_2 Mycobacterium marinum M EsxA-like protein, EsxA_2 YP_001848520.1 226072 D 216594 CDS YP_001848521.1 183980230 6224413 226403..226750 1 NC_010612.1 hypothetical protein 226750 6224413 MMAR_0197 Mycobacterium marinum M hypothetical protein YP_001848521.1 226403 D 216594 CDS YP_001848522.1 183980231 6224414 226758..227129 1 NC_010612.1 hypothetical protein 227129 6224414 MMAR_0198 Mycobacterium marinum M hypothetical protein YP_001848522.1 226758 D 216594 CDS YP_001848523.1 183980232 6224415 227133..229202 1 NC_010612.1 hypothetical protein 229202 6224415 MMAR_0199 Mycobacterium marinum M hypothetical protein YP_001848523.1 227133 D 216594 CDS YP_001848524.1 183980233 6224416 229316..229807 1 NC_010612.1 hypothetical protein 229807 6224416 MMAR_0200 Mycobacterium marinum M hypothetical protein YP_001848524.1 229316 D 216594 CDS YP_001848525.1 183980234 6224417 complement(229926..230201) 1 NC_010612.1 hypothetical protein 230201 6224417 MMAR_0201 Mycobacterium marinum M hypothetical protein YP_001848525.1 229926 R 216594 CDS YP_001848526.1 183980235 6224418 complement(230276..231814) 1 NC_010612.1 hypothetical protein 231814 6224418 MMAR_0202 Mycobacterium marinum M hypothetical protein YP_001848526.1 230276 R 216594 CDS YP_001848527.1 183980236 6224419 232431..233972 1 NC_010612.1 hypothetical protein 233972 6224419 MMAR_0203 Mycobacterium marinum M hypothetical protein YP_001848527.1 232431 D 216594 CDS YP_001848528.1 183980237 6224420 234056..234607 1 NC_010612.1 hypothetical protein 234607 6224420 MMAR_0204 Mycobacterium marinum M hypothetical protein YP_001848528.1 234056 D 216594 CDS YP_001848529.1 183980238 6224421 complement(234666..236270) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hypothetical protein 236270 6224421 MMAR_0205 Mycobacterium marinum M hypothetical protein YP_001848529.1 234666 R 216594 CDS YP_001848530.1 183980239 6224422 complement(236388..237773) 1 NC_010612.1 involved in gluconeogenesis from serine [catalytic activity: L-serine + H2O = pyruvate + NH3 + H2O]; L-serine dehydratase SdaA 237773 sdaA 6224422 sdaA Mycobacterium marinum M L-serine dehydratase SdaA YP_001848530.1 236388 R 216594 CDS YP_001848531.1 183980240 6224423 complement(237770..239047) 1 NC_010612.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 239047 glyA 6224423 glyA Mycobacterium marinum M serine hydroxymethyltransferase YP_001848531.1 237770 R 216594 CDS YP_001848532.1 183980241 6224424 complement(239044..239448) 1 NC_010612.1 the glycine cleavage system catalyses the degradation of glycine. the H protein shuttles the methylamine group of glycine from the P protein to the T protein; glycine cleavage system H protein GcvH 239448 gcvH_1 6224424 gcvH_1 Mycobacterium marinum M glycine cleavage system H protein GcvH YP_001848532.1 239044 R 216594 CDS YP_001848533.1 183980242 6224425 complement(239495..240622) 1 NC_010612.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 240622 gcvT 6224425 gcvT Mycobacterium marinum M glycine cleavage system aminomethyltransferase T YP_001848533.1 239495 R 216594 CDS YP_001848534.1 183980243 6224426 complement(240640..243525) 1 NC_010612.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 243525 gcvB_1 6224426 gcvB_1 Mycobacterium marinum M glycine dehydrogenase YP_001848534.1 240640 R 216594 CDS YP_001848535.1 183980244 6224427 243865..243963 1 NC_010612.1 hypothetical protein 243963 6224427 MMAR_5544 Mycobacterium marinum M hypothetical protein YP_001848535.1 243865 D 216594 CDS YP_001848536.1 183980245 6224428 complement(244095..245465) 1 NC_010612.1 function unknown; involved in cellular metabolism; oxidoreductase 245465 6224428 MMAR_0212 Mycobacterium marinum M oxidoreductase YP_001848536.1 244095 R 216594 CDS YP_001848537.1 183980246 6224429 complement(245475..247235) 1 NC_010612.1 hydrolizes specific D-amino acid; D-amino acid aminohydrolase 247235 6224429 MMAR_0213 Mycobacterium marinum M D-amino acid aminohydrolase YP_001848537.1 245475 R 216594 CDS YP_001848538.1 183980247 6224430 complement(247401..247778) 1 NC_010612.1 function unknown. domain identity suggests anti- anti-sigma regulatory factor; hypothetical protein 247778 6224430 MMAR_0214 Mycobacterium marinum M hypothetical protein YP_001848538.1 247401 R 216594 CDS YP_001848539.1 183980248 6224431 248068..249117 1 NC_010612.1 involved in active transport of glutamine across the membrane (import). responsible for the translocation of the substrate across the membrane; glutamine-transport transmembrane protein ABC transporter 249117 6224431 MMAR_0215 Mycobacterium marinum M glutamine-transport transmembrane protein ABC transporter YP_001848539.1 248068 D 216594 CDS YP_001848540.1 183980249 6224432 249121..250113 1 NC_010612.1 involved in active transport of glutamine across the membrane (import). responsible for the translocation of the substrate across the membrane; glutamine-transport ABC transporter ATP-binding protein 250113 6224432 MMAR_0216 Mycobacterium marinum M glutamine-transport ABC transporter ATP-binding protein YP_001848540.1 249121 D 216594 CDS YP_001848541.1 183980250 6224433 complement(250135..251085) 1 NC_010612.1 lipoprotein 251085 6224433 MMAR_0217 Mycobacterium marinum M lipoprotein YP_001848541.1 250135 R 216594 CDS YP_001848542.1 183980251 6224434 complement(251170..252468) 1 NC_010612.1 hypothetical protein 252468 6224434 MMAR_0218 Mycobacterium marinum M hypothetical protein YP_001848542.1 251170 R 216594 CDS YP_001848543.1 183980252 6224435 complement(252597..252974) 1 NC_010612.1 hypothetical protein 252974 6224435 MMAR_0219 Mycobacterium marinum M hypothetical protein YP_001848543.1 252597 R 216594 CDS YP_001848544.1 183980253 6224436 complement(253047..254222) 1 NC_010612.1 hypothetical protein 254222 6224436 MMAR_0220 Mycobacterium marinum M hypothetical protein YP_001848544.1 253047 R 216594 CDS YP_001848545.1 183980254 6224437 complement(254219..255316) 1 NC_010612.1 hypothetical protein 255316 6224437 MMAR_0221 Mycobacterium marinum M hypothetical protein YP_001848545.1 254219 R 216594 CDS YP_001848546.1 183980255 6224438 255379..255972 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 255972 6224438 MMAR_0222 Mycobacterium marinum M TetR family transcriptional regulator YP_001848546.1 255379 D 216594 CDS YP_001848547.1 183980256 6224439 complement(256036..256866) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 256866 6224439 MMAR_0223 Mycobacterium marinum M oxidoreductase YP_001848547.1 256036 R 216594 CDS YP_001848548.1 183980257 6224440 256927..257532 1 NC_010612.1 possibly involved in transcriptional mechanism; transcriptional regulatory protein 257532 6224440 MMAR_0224 Mycobacterium marinum M transcriptional regulatory protein YP_001848548.1 256927 D 216594 CDS YP_001848549.1 183980258 6224441 257653..258273 1 NC_010612.1 hypothetical protein 258273 6224441 MMAR_0225 Mycobacterium marinum M hypothetical protein YP_001848549.1 257653 D 216594 CDS YP_001848550.1 183980259 6224442 258629..259237 1 NC_010612.1 hypothetical protein 259237 6224442 MMAR_0226 Mycobacterium marinum M hypothetical protein YP_001848550.1 258629 D 216594 CDS YP_001848551.1 183980260 6224443 complement(259288..260268) 1 NC_010612.1 lipoprotein LpqP 260268 lpqP_1 6224443 lpqP_1 Mycobacterium marinum M lipoprotein LpqP YP_001848551.1 259288 R 216594 CDS YP_001848552.1 183980261 6224444 260305..260754 1 NC_010612.1 function unknown. contains HTH motif. may be involved in transcription regulation; hypothetical protein 260754 6224444 MMAR_0228 Mycobacterium marinum M hypothetical protein YP_001848552.1 260305 D 216594 CDS YP_001848553.1 183980262 6224445 complement(260799..261605) 1 NC_010612.1 hypothetical protein 261605 6224445 MMAR_0229 Mycobacterium marinum M hypothetical protein YP_001848553.1 260799 R 216594 CDS YP_001848554.1 183980263 6224446 261665..262849 1 NC_010612.1 function unknown, involved in cellular metabolism; dioxygenase 262849 6224446 MMAR_0230 Mycobacterium marinum M dioxygenase YP_001848554.1 261665 D 216594 CDS YP_001848555.1 183980264 6224447 complement(262878..265247) 1 NC_010612.1 cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly copper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]; ATPase P 265247 ctpA_1 6224447 ctpA_1 Mycobacterium marinum M ATPase P YP_001848555.1 262878 R 216594 CDS YP_001848556.1 183980265 6224448 complement(265258..266148) 1 NC_010612.1 hypothetical protein 266148 6224448 MMAR_0232 Mycobacterium marinum M hypothetical protein YP_001848556.1 265258 R 216594 CDS YP_001848557.1 183980266 6224449 complement(266145..266357) 1 NC_010612.1 contains copper chaperone domain; hypothetical protein 266357 6224449 MMAR_0233 Mycobacterium marinum M hypothetical protein YP_001848557.1 266145 R 216594 CDS YP_001848558.1 183980267 6224450 266541..267032 1 NC_010612.1 hypothetical protein 267032 6224450 MMAR_0234 Mycobacterium marinum M hypothetical protein YP_001848558.1 266541 D 216594 CDS YP_001848559.1 183980268 6224451 complement(267056..267619) 1 NC_010612.1 pyridoxamine 5'-phosphate oxidase 267619 6224451 MMAR_0235 Mycobacterium marinum M pyridoxamine 5'-phosphate oxidase YP_001848559.1 267056 R 216594 CDS YP_001848560.1 183980269 6224452 complement(267658..268668) 1 NC_010612.1 function unknown. possibly involved in cellular metabolism; hypothetical protein 268668 6224452 MMAR_0236 Mycobacterium marinum M hypothetical protein YP_001848560.1 267658 R 216594 CDS YP_001848561.1 183980270 6224453 complement(268665..269282) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 269282 6224453 MMAR_0237 Mycobacterium marinum M TetR family transcriptional regulator YP_001848561.1 268665 R 216594 CDS YP_001848562.1 183980271 6224454 269478..270107 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 270107 6224454 MMAR_0238 Mycobacterium marinum M TetR family transcriptional regulator YP_001848562.1 269478 D 216594 CDS YP_001848563.1 183980272 6224455 270210..272009 1 NC_010612.1 function unknown; probably involved in cellular metabolism; monooxygenase 272009 6224455 MMAR_0239 Mycobacterium marinum M monooxygenase YP_001848563.1 270210 D 216594 CDS YP_001848564.1 183980273 6224456 272006..273682 1 NC_010612.1 function unknown, involved in cellular metabolism; monoooxygenase 273682 6224456 MMAR_0240 Mycobacterium marinum M monoooxygenase YP_001848564.1 272006 D 216594 CDS YP_001848565.1 183980274 6224457 complement(273566..274723) 1 NC_010612.1 function unknown, generates an aldehyde (or perhaps a ketone) from an alcohol; zinc-type alcohol dehydrogenase AdhD 274723 adhD 6224457 adhD Mycobacterium marinum M zinc-type alcohol dehydrogenase AdhD YP_001848565.1 273566 R 216594 CDS YP_001848566.1 183980275 6224458 274874..276589 1 NC_010612.1 PE-PGRS family protein 276589 6224458 MMAR_0242 Mycobacterium marinum M PE-PGRS family protein YP_001848566.1 274874 D 216594 CDS YP_001848567.1 183980276 6224459 complement(276635..277447) 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short chain dehydrogenase 277447 6224459 MMAR_0243 Mycobacterium marinum M short chain dehydrogenase YP_001848567.1 276635 R 216594 CDS YP_001848568.1 183980277 6224460 277563..278162 1 NC_010612.1 thought to cause methylation; methyltransferase/methylase 278162 6224460 MMAR_0244 Mycobacterium marinum M methyltransferase/methylase YP_001848568.1 277563 D 216594 CDS YP_001848569.1 183980278 6224461 complement(278220..279029) 1 NC_010612.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_7 279029 echA8_7 6224461 echA8_7 Mycobacterium marinum M enoyl-CoA hydratase, EchA8_7 YP_001848569.1 278220 R 216594 CDS YP_001848570.1 183980279 6224462 279266..280096 1 NC_010612.1 hypothetical protein 280096 6224462 MMAR_0246 Mycobacterium marinum M hypothetical protein YP_001848570.1 279266 D 216594 CDS YP_001848571.1 183980280 6224463 complement(280121..280735) 1 NC_010612.1 hypothetical protein 280735 6224463 MMAR_0247 Mycobacterium marinum M hypothetical protein YP_001848571.1 280121 R 216594 CDS YP_001848572.1 183980281 6224464 280805..281665 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 281665 6224464 MMAR_0248 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001848572.1 280805 D 216594 CDS YP_001848573.1 183980282 6224465 281711..282340 1 NC_010612.1 possibly involved in transcriptional mechanism; TetR family transcriptional regulator 282340 6224465 MMAR_0249 Mycobacterium marinum M TetR family transcriptional regulator YP_001848573.1 281711 D 216594 CDS YP_001848574.1 183980283 6224466 282337..283161 1 NC_010612.1 hypothetical protein 283161 6224466 MMAR_0250 Mycobacterium marinum M hypothetical protein YP_001848574.1 282337 D 216594 CDS YP_001848575.1 183980284 6224467 283272..284027 1 NC_010612.1 responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and s- adenosylhomocysteine (sah) [catalytic activity 1: methylthioadenosine + H2O = adenine + 5-methylthio-D- ribose] [catalytic activity 2: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine]; bifunctional Mta/Sah nucleosidase Mtn 284027 mtn 6224467 mtn Mycobacterium marinum M bifunctional Mta/Sah nucleosidase Mtn YP_001848575.1 283272 D 216594 CDS YP_001848576.1 183980285 6224468 284385..284870 1 NC_010612.1 hypothetical protein 284870 6224468 MMAR_0253 Mycobacterium marinum M hypothetical protein YP_001848576.1 284385 D 216594 CDS YP_001848577.1 183980286 6224469 284972..285775 1 NC_010612.1 function unknown, but possibly involvement in lipid metabolism; ketoacyl reductase 285775 6224469 MMAR_0254 Mycobacterium marinum M ketoacyl reductase YP_001848577.1 284972 D 216594 CDS YP_001848578.1 183980287 6224470 285857..288769 1 NC_010612.1 thought to be involved in fatty acid transport; transmembrane transport protein MmpL 288769 mmpL5_4 6224470 mmpL5_4 Mycobacterium marinum M transmembrane transport protein MmpL YP_001848578.1 285857 D 216594 CDS YP_001848579.1 183980288 6224471 complement(288793..293043) 1 NC_010612.1 involved in lipid metabolism; non-ribosomal peptide synthetase 293043 6224471 MMAR_0256 Mycobacterium marinum M non-ribosomal peptide synthetase YP_001848579.1 288793 R 216594 CDS YP_001848580.1 183980289 6224472 complement(293040..293291) 1 NC_010612.1 hypothetical protein 293291 6224472 MMAR_0257 Mycobacterium marinum M hypothetical protein YP_001848580.1 293040 R 216594 CDS YP_001848581.1 183980290 6224473 complement(293284..294879) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 294879 fadD10 6224473 fadD10 Mycobacterium marinum M acyl-CoA synthetase YP_001848581.1 293284 R 216594 CDS YP_001848582.1 183980291 6224474 complement(294908..295462) 1 NC_010612.1 hypothetical protein 295462 6224474 MMAR_0259 Mycobacterium marinum M hypothetical protein YP_001848582.1 294908 R 216594 CDS YP_001848583.1 183980292 6224475 complement(295459..296328) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 296328 6224475 MMAR_0260 Mycobacterium marinum M oxidoreductase YP_001848583.1 295459 R 216594 CDS YP_001848584.1 183980293 6224476 complement(296522..297940) 1 NC_010612.1 PPE family protein 297940 6224476 MMAR_0261 Mycobacterium marinum M PPE family protein YP_001848584.1 296522 R 216594 CDS YP_001848585.1 183980294 6224477 298268..299077 1 NC_010612.1 function unknown, but supposed involved in lipid metabolism; O-methyltransferase Omt 299077 omt_1 6224477 omt_1 Mycobacterium marinum M O-methyltransferase Omt YP_001848585.1 298268 D 216594 CDS YP_001848586.1 183980295 6224478 299159..299872 1 NC_010612.1 hypothetical protein 299872 6224478 MMAR_0263 Mycobacterium marinum M hypothetical protein YP_001848586.1 299159 D 216594 CDS YP_001848587.1 183980296 6224479 complement(299893..302184) 1 NC_010612.1 cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly copper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]; cation transporter p-type ATPase a CtpA 302184 ctpA 6224479 ctpA Mycobacterium marinum M cation transporter p-type ATPase a CtpA YP_001848587.1 299893 R 216594 CDS YP_001848588.1 183980297 6224480 302309..302863 1 NC_010612.1 involved in promoter recognition, transcription initiation; ECF subfamily RNA polymerase sigma factor 302863 sigC_1 6224480 sigC_1 Mycobacterium marinum M ECF subfamily RNA polymerase sigma factor YP_001848588.1 302309 D 216594 CDS YP_001848589.1 183980298 6224481 complement(302899..303642) 1 NC_010612.1 hypothetical protein 303642 6224481 MMAR_0266 Mycobacterium marinum M hypothetical protein YP_001848589.1 302899 R 216594 CDS YP_001848590.1 183980299 6224482 303807..305783 1 NC_010612.1 integral membrane protein 305783 6224482 MMAR_0267 Mycobacterium marinum M integral membrane protein YP_001848590.1 303807 D 216594 CDS YP_001848591.1 183980300 6224483 complement(305800..306018) 1 NC_010612.1 hypothetical protein 306018 6224483 MMAR_0268 Mycobacterium marinum M hypothetical protein YP_001848591.1 305800 R 216594 CDS YP_001848592.1 183980301 6224484 complement(306011..308284) 1 NC_010612.1 cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly coopper) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + orthophosphate + cation(out)]; cation-transporter p-type ATPase B CtpB 308284 ctpB 6224484 ctpB Mycobacterium marinum M cation-transporter p-type ATPase B CtpB YP_001848592.1 306011 R 216594 CDS YP_001848593.1 183980302 6224485 complement(308529..309335) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; short-chain type dehydrogenase/reductase 309335 6224485 MMAR_0271 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001848593.1 308529 R 216594 CDS YP_001848594.1 183980303 6224486 complement(309447..310718) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 226B1 Cyp226B1 310718 cyp226B1 6224486 cyp226B1 Mycobacterium marinum M cytochrome P450 226B1 Cyp226B1 YP_001848594.1 309447 R 216594 CDS YP_001848595.1 183980304 6224487 complement(311150..312412) 1 NC_010612.1 function unknown role in cellular metabolism; amidohydrolase 312412 6224487 MMAR_0273 Mycobacterium marinum M amidohydrolase YP_001848595.1 311150 R 216594 CDS YP_001848596.1 183980305 6224488 complement(312399..313694) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 271A1 Cyp271A1 313694 cyp271A1 6224488 cyp271A1 Mycobacterium marinum M cytochrome P450 271A1 Cyp271A1 YP_001848596.1 312399 R 216594 CDS YP_001848597.1 183980306 6224489 complement(313695..314858) 1 NC_010612.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 314858 ispG 6224489 ispG Mycobacterium marinum M 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_001848597.1 313695 R 216594 CDS YP_001848598.1 183980307 6224490 complement(314855..316708) 1 NC_010612.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 316708 dxs2 6224490 dxs2 Mycobacterium marinum M 1-deoxy-D-xylulose-5-phosphate synthase YP_001848598.1 314855 R 216594 CDS YP_001848599.1 183980308 6224491 complement(316705..317706) 1 NC_010612.1 LytB is involved in the trunk line of the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis; LytB-related protein LytB2 317706 lytB2 6224491 lytB2 Mycobacterium marinum M LytB-related protein LytB2 YP_001848599.1 316705 R 216594 CDS YP_001848600.1 183980309 6224492 complement(317703..318719) 1 NC_010612.1 hypothetical protein 318719 6224492 MMAR_0278 Mycobacterium marinum M hypothetical protein YP_001848600.1 317703 R 216594 CDS YP_001848601.1 183980310 6224493 complement(318780..319523) 1 NC_010612.1 hypothetical protein 319523 6224493 MMAR_0279 Mycobacterium marinum M hypothetical protein YP_001848601.1 318780 R 216594 CDS YP_001848602.1 183980311 6224494 complement(319581..320576) 1 NC_010612.1 involved in isoprenoid biosynthesis. enzymes in this class catalyze the ionization of farnesyl diphosphate, followed by the formation of a macrocyclic intermediate by bond formation between C1 with either C10 (aristolochene synthase) or C11 (pentalenene synthase), resulting in production of tricyclic hydrocarbon pentalenene or bicyclic hydrocarbon aristolochene; non-plant terpene cyclase (C1 class) 320576 6224494 MMAR_0280 Mycobacterium marinum M non-plant terpene cyclase (C1 class) YP_001848602.1 319581 R 216594 CDS YP_001848603.1 183980312 6224495 complement(320584..321972) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. some have been shown to bind tightly to a range of azole-based antifungal drugs (E.G. miconazole, clotrimazole); cytochrome P450 183B1 Cyp183B1 321972 cyp183B1 6224495 cyp183B1 Mycobacterium marinum M cytochrome P450 183B1 Cyp183B1 YP_001848603.1 320584 R 216594 CDS YP_001848604.1 183980313 6224496 complement(321985..322974) 1 NC_010612.1 involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (IPP, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths; polyprenyl synthetase IdsB_3 322974 idsB_3 6224496 idsB_3 Mycobacterium marinum M polyprenyl synthetase IdsB_3 YP_001848604.1 321985 R 216594 CDS YP_001848605.1 183980314 6224497 323882..325237 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 274A1 Cyp274A1 325237 cyp274A1 6224497 cyp274A1 Mycobacterium marinum M cytochrome P450 274A1 Cyp274A1 YP_001848605.1 323882 D 216594 CDS YP_001848606.1 183980315 6224498 325297..327039 1 NC_010612.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB 327039 plcB_3 6224498 plcB_3 Mycobacterium marinum M membrane-associated phospholipase C2 PlcB YP_001848606.1 325297 D 216594 CDS YP_001848607.1 183980316 6224499 327193..328710 1 NC_010612.1 hypothetical protein 328710 6224499 MMAR_0285 Mycobacterium marinum M hypothetical protein YP_001848607.1 327193 D 216594 CDS YP_001848608.1 183980317 6224500 complement(328780..330156) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; lignin peroxidase LipJ 330156 lipJ 6224500 lipJ Mycobacterium marinum M lignin peroxidase LipJ YP_001848608.1 328780 R 216594 CDS YP_001848609.1 183980318 6224501 complement(330159..330764) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 330764 6224501 MMAR_0287 Mycobacterium marinum M transcriptional regulatory protein YP_001848609.1 330159 R 216594 CDS YP_001848610.1 183980319 6224502 330953..331903 1 NC_010612.1 hypothetical protein 331903 6224502 MMAR_0288 Mycobacterium marinum M hypothetical protein YP_001848610.1 330953 D 216594 CDS YP_001848611.1 183980320 6224503 complement(331924..332187) 1 NC_010612.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 332187 rpsR2 6224503 rpsR2 Mycobacterium marinum M 30S ribosomal protein S18 YP_001848611.1 331924 R 216594 CDS YP_001848612.1 183980321 6224504 complement(332194..332499) 1 NC_010612.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 332499 rpsN 6224504 rpsN Mycobacterium marinum M 30S ribosomal protein S14 YP_001848612.1 332194 R 216594 CDS YP_001848613.1 183980322 6224505 complement(332500..332664) 1 NC_010612.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 332664 rpmG 6224505 rpmG Mycobacterium marinum M 50S ribosomal protein L33 YP_001848613.1 332500 R 216594 CDS YP_001848614.1 183980323 6224506 complement(332664..332900) 1 NC_010612.1 involved in ribosome activity; 50S ribosomal protein L28 332900 rpmB2 6224506 rpmB2 Mycobacterium marinum M 50S ribosomal protein L28 YP_001848614.1 332664 R 216594 CDS YP_001848615.1 183980324 6224507 333030..334226 1 NC_010612.1 hypothetical protein 334226 6224507 MMAR_0293 Mycobacterium marinum M hypothetical protein YP_001848615.1 333030 D 216594 CDS YP_001848616.1 183980325 6224508 334223..334495 1 NC_010612.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 334495 rpmE2 6224508 rpmE2 Mycobacterium marinum M 50S ribosomal protein L31 YP_001848616.1 334223 D 216594 CDS YP_001848617.1 183980326 6224509 334665..335564 1 NC_010612.1 function unknown; supposed involved in cellular metabolism; short-chain type dehydrogenase/reductase 335564 6224509 MMAR_0295 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001848617.1 334665 D 216594 CDS YP_001848618.1 183980327 6224510 335567..337153 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 337153 fadD12_2 6224510 fadD12_2 Mycobacterium marinum M acyl-CoA synthetase YP_001848618.1 335567 D 216594 CDS YP_001848619.1 183980328 6224511 complement(337126..341988) 1 NC_010612.1 cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly magnesium) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]; cation-transporter ATPase I CtpI 341988 ctpI 6224511 ctpI Mycobacterium marinum M cation-transporter ATPase I CtpI YP_001848619.1 337126 R 216594 CDS YP_001848620.1 183980329 6224512 complement(342457..342729) 1 NC_010612.1 hypothetical protein 342729 6224512 MMAR_0298 Mycobacterium marinum M hypothetical protein YP_001848620.1 342457 R 216594 CDS YP_001848621.1 183980330 6224513 343064..344737 1 NC_010612.1 PE-PGRS family protein 344737 6224513 MMAR_0299 Mycobacterium marinum M PE-PGRS family protein YP_001848621.1 343064 D 216594 CDS YP_001848622.1 183980331 6224514 344862..345731 1 NC_010612.1 serine protease 345731 6224514 MMAR_0300 Mycobacterium marinum M serine protease YP_001848622.1 344862 D 216594 CDS YP_001848623.1 183980332 6224515 345766..346227 1 NC_010612.1 hypothetical protein 346227 6224515 MMAR_0301 Mycobacterium marinum M hypothetical protein YP_001848623.1 345766 D 216594 CDS YP_001848624.1 183980333 6224516 complement(346209..346997) 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 346997 6224516 MMAR_0302 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001848624.1 346209 R 216594 CDS YP_001848625.1 183980334 6224517 complement(346999..348609) 1 NC_010612.1 acyl-CoA synthetase 348609 6224517 MMAR_0303 Mycobacterium marinum M acyl-CoA synthetase YP_001848625.1 346999 R 216594 CDS YP_001848626.1 183980335 6224518 complement(348619..349398) 1 NC_010612.1 involved in transcriptional mechanism; GntR family transcriptional regulator 349398 6224518 MMAR_0304 Mycobacterium marinum M GntR family transcriptional regulator YP_001848626.1 348619 R 216594 CDS YP_001848627.1 183980336 6224519 complement(349411..351033) 1 NC_010612.1 hypothetical protein 351033 6224519 MMAR_0305 Mycobacterium marinum M hypothetical protein YP_001848627.1 349411 R 216594 CDS YP_001848628.1 183980337 6224520 351170..352045 1 NC_010612.1 function unknown; possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 352045 6224520 MMAR_0306 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001848628.1 351170 D 216594 CDS YP_001848629.1 183980338 6224521 352047..353441 1 NC_010612.1 function unknown; involved in cellular metabolism; dioxygenase 353441 6224521 MMAR_0307 Mycobacterium marinum M dioxygenase YP_001848629.1 352047 D 216594 CDS YP_001848630.1 183980339 6224522 353456..354637 1 NC_010612.1 function unknown, probably involved in cellular metabolism; monooxygenase 354637 6224522 MMAR_0308 Mycobacterium marinum M monooxygenase YP_001848630.1 353456 D 216594 CDS YP_001848631.1 183980340 6224523 354634..356496 1 NC_010612.1 function unknown, probably involved in cellular metabolism; monoxygenase 356496 6224523 MMAR_0309 Mycobacterium marinum M monoxygenase YP_001848631.1 354634 D 216594 CDS YP_001848632.1 183980341 6224524 356496..357431 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 357431 6224524 MMAR_0310 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001848632.1 356496 D 216594 CDS YP_001848633.1 183980342 6224525 357424..358644 1 NC_010612.1 function unknown. possibly involved in energy production and conversion; hypothetical protein 358644 6224525 MMAR_0311 Mycobacterium marinum M hypothetical protein YP_001848633.1 357424 D 216594 CDS YP_001848634.1 183980343 6224560 358882..360894 1 NC_010612.1 function unknown, probably involved in cellular metabolism; transmembrane acyltransferase 360894 6224560 MMAR_0312 Mycobacterium marinum M transmembrane acyltransferase YP_001848634.1 358882 D 216594 CDS YP_001848635.1 183980344 6224561 complement(360898..361563) 1 NC_010612.1 thought to be involved in transfer of methyl group; O-methyltransferase 361563 6224561 MMAR_0313 Mycobacterium marinum M O-methyltransferase YP_001848635.1 360898 R 216594 CDS YP_001848636.1 183980345 6224562 362138..362353 1 NC_010612.1 hypothetical protein 362353 6224562 MMAR_0314 Mycobacterium marinum M hypothetical protein YP_001848636.1 362138 D 216594 CDS YP_001848637.1 183980346 6224563 362455..364209 1 NC_010612.1 H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane; divalent cation-transport integral membrane protein 364209 6224563 MMAR_0315 Mycobacterium marinum M divalent cation-transport integral membrane protein YP_001848637.1 362455 D 216594 CDS YP_001848638.1 183980347 6224564 complement(364261..365016) 1 NC_010612.1 hypothetical protein 365016 6224564 MMAR_0316 Mycobacterium marinum M hypothetical protein YP_001848638.1 364261 R 216594 CDS YP_001848639.1 183980348 6224565 365147..366364 1 NC_010612.1 could effect functions of OxyR during evolution; oxidative stress response regulatory protein OxyS 366364 oxyS 6224565 oxyS Mycobacterium marinum M oxidative stress response regulatory protein OxyS YP_001848639.1 365147 D 216594 CDS YP_001848640.1 183980349 6224566 complement(366348..368111) 1 NC_010612.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase 368111 oxcA 6224566 oxcA Mycobacterium marinum M putative oxalyl-CoA decarboxylase YP_001848640.1 366348 R 216594 CDS YP_001848641.1 183980350 6224567 368378..370012 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 370012 fadD7 6224567 fadD7 Mycobacterium marinum M acyl-CoA synthetase YP_001848641.1 368378 D 216594 CDS YP_001848642.1 183980351 6224568 complement(370009..370485) 1 NC_010612.1 hypothetical protein 370485 6224568 MMAR_0320 Mycobacterium marinum M hypothetical protein YP_001848642.1 370009 R 216594 CDS YP_001848643.1 183980352 6224569 complement(370501..372657) 1 NC_010612.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 372657 fusA2 6224569 fusA2 Mycobacterium marinum M elongation factor G YP_001848643.1 370501 R 216594 CDS YP_001848644.1 183980353 6224570 complement(372828..373229) 1 NC_010612.1 hypothetical protein 373229 6224570 MMAR_0322 Mycobacterium marinum M hypothetical protein YP_001848644.1 372828 R 216594 CDS YP_001848645.1 183980354 6224571 373300..373800 1 NC_010612.1 maybe involved in oxidization of aromatic hydrocarbons; dioxygenase subunit beta 373800 6224571 MMAR_0323 Mycobacterium marinum M dioxygenase subunit beta YP_001848645.1 373300 D 216594 CDS YP_001848646.1 183980355 6224572 373913..374986 1 NC_010612.1 function unknown, possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residues); serine protease PepA 374986 pepA 6224572 pepA Mycobacterium marinum M serine protease PepA YP_001848646.1 373913 D 216594 CDS YP_001848647.1 183980356 6224573 375105..376892 1 NC_010612.1 involved in trehalose biosynthesis (protective effect). converts maltose to trehalose. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)- linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway); trehalose synthase TreS 376892 treS 6224573 treS Mycobacterium marinum M trehalose synthase TreS YP_001848647.1 375105 D 216594 CDS YP_001848648.1 183980357 6224574 376966..378333 1 NC_010612.1 hypothetical protein 378333 6224574 MMAR_0326 Mycobacterium marinum M hypothetical protein YP_001848648.1 376966 D 216594 CDS YP_001848649.1 183980358 6224575 378448..379128 1 NC_010612.1 hypothetical protein 379128 6224575 MMAR_0327 Mycobacterium marinum M hypothetical protein YP_001848649.1 378448 D 216594 CDS YP_001848650.1 183980359 6224576 complement(379208..380248) 1 NC_010612.1 proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity; secreted antigen 85-C FbpC 380248 fbpC 6224576 fbpC Mycobacterium marinum M secreted antigen 85-C FbpC YP_001848650.1 379208 R 216594 CDS YP_001848651.1 183980360 6224577 complement(380601..381098) 1 NC_010612.1 phosphoesterase 381098 6224577 MMAR_0329 Mycobacterium marinum M phosphoesterase YP_001848651.1 380601 R 216594 CDS YP_001848652.1 183980361 6224578 381135..381590 1 NC_010612.1 acyl dehydratase 381590 6224578 MMAR_0330 Mycobacterium marinum M acyl dehydratase YP_001848652.1 381135 D 216594 CDS YP_001848653.1 183980362 6224579 complement(381671..382966) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE1 382966 fadE1 6224579 fadE1 Mycobacterium marinum M acyl-CoA dehydrogenase FadE1 YP_001848653.1 381671 R 216594 CDS YP_001848654.1 183980363 6224580 383128..383733 1 NC_010612.1 function unknown, probably involved in cellular metabolism; acetyltransferase 383733 6224580 MMAR_0332 Mycobacterium marinum M acetyltransferase YP_001848654.1 383128 D 216594 CDS YP_001848655.1 183980364 6224581 complement(383770..385800) 1 NC_010612.1 hypothetical protein 385800 6224581 MMAR_0333 Mycobacterium marinum M hypothetical protein YP_001848655.1 383770 R 216594 CDS YP_001848656.1 183980365 6224582 complement(385931..386599) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 386599 6224582 MMAR_0334 Mycobacterium marinum M TetR family transcriptional regulator YP_001848656.1 385931 R 216594 CDS YP_001848657.1 183980366 6224583 386670..387767 1 NC_010612.1 function unknown, contains flavodoxin reductases (ferredoxin-NADPH reductases) family 1 domain. [energy production and conversion]; flavodoxin oxidoreductase 387767 6224583 MMAR_0335 Mycobacterium marinum M flavodoxin oxidoreductase YP_001848657.1 386670 D 216594 CDS YP_001848658.1 183980367 6224584 387803..388936 1 NC_010612.1 thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O]; linoleoyl-CoA desaturase, DesA3_2 388936 desA3_2 6224584 desA3_2 Mycobacterium marinum M linoleoyl-CoA desaturase, DesA3_2 YP_001848658.1 387803 D 216594 CDS YP_001848659.1 183980368 6224585 389206..389730 1 NC_010612.1 hypothetical protein 389730 6224585 MMAR_0337 Mycobacterium marinum M hypothetical protein YP_001848659.1 389206 D 216594 CDS YP_001848660.1 183980369 6224586 389730..390788 1 NC_010612.1 function unknown, probably involved in cellular metabolism; coenzyme F420-dependent oxidoreductase 390788 6224586 MMAR_0338 Mycobacterium marinum M coenzyme F420-dependent oxidoreductase YP_001848660.1 389730 D 216594 CDS YP_001848661.1 183980370 6224587 complement(390790..391902) 1 NC_010612.1 hypothetical protein 391902 6224587 MMAR_0339 Mycobacterium marinum M hypothetical protein YP_001848661.1 390790 R 216594 CDS YP_001848662.1 183980371 6224588 complement(391899..392498) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 392498 6224588 MMAR_0340 Mycobacterium marinum M TetR family transcriptional regulator YP_001848662.1 391899 R 216594 CDS YP_001848663.1 183980372 6224589 392605..393768 1 NC_010612.1 hypothetical protein 393768 6224589 MMAR_0341 Mycobacterium marinum M hypothetical protein YP_001848663.1 392605 D 216594 CDS YP_001848664.1 183980373 6224590 393807..394697 1 NC_010612.1 thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol]; epoxide hydrolase EphF 394697 ephF 6224590 ephF Mycobacterium marinum M epoxide hydrolase EphF YP_001848664.1 393807 D 216594 CDS YP_001848665.1 183980374 6224591 complement(394761..395804) 1 NC_010612.1 oxido-reduction; zinc-dependent alcohol dehydrogenase 395804 6224591 MMAR_0343 Mycobacterium marinum M zinc-dependent alcohol dehydrogenase YP_001848665.1 394761 R 216594 CDS YP_001848666.1 183980375 6224592 complement(395811..396023) 1 NC_010612.1 hypothetical protein 396023 6224592 MMAR_0344 Mycobacterium marinum M hypothetical protein YP_001848666.1 395811 R 216594 CDS YP_001848667.1 183980376 6224593 complement(396069..396674) 1 NC_010612.1 could be involved in transcriptional mechanism; transcriptional regulatory protein 396674 6224593 MMAR_0345 Mycobacterium marinum M transcriptional regulatory protein YP_001848667.1 396069 R 216594 CDS YP_001848668.1 183980377 6224594 396804..398129 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 138A3 Cyp138A3 398129 cyp138A3 6224594 cyp138A3 Mycobacterium marinum M cytochrome P450 138A3 Cyp138A3 YP_001848668.1 396804 D 216594 CDS YP_001848669.1 183980378 6224595 complement(398166..398681) 1 NC_010612.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 398681 msrA 6224595 msrA Mycobacterium marinum M methionine sulfoxide reductase A YP_001848669.1 398166 R 216594 CDS YP_001848670.1 183980379 6224596 398841..399347 1 NC_010612.1 hypothetical protein 399347 6224596 MMAR_0348 Mycobacterium marinum M hypothetical protein YP_001848670.1 398841 D 216594 CDS YP_001848671.1 183980380 6224597 399344..400366 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 400366 6224597 MMAR_0349 Mycobacterium marinum M oxidoreductase YP_001848671.1 399344 D 216594 CDS YP_001848672.1 183980381 6224598 400476..400856 1 NC_010612.1 hypothetical protein 400856 6224598 MMAR_0350 Mycobacterium marinum M hypothetical protein YP_001848672.1 400476 D 216594 CDS YP_001848673.1 183980382 6224599 complement(400843..401244) 1 NC_010612.1 hypothetical protein 401244 6224599 MMAR_0351 Mycobacterium marinum M hypothetical protein YP_001848673.1 400843 R 216594 CDS YP_001848674.1 183980383 6224600 401317..402228 1 NC_010612.1 DNA glycosylase 402228 6224600 MMAR_0352 Mycobacterium marinum M DNA glycosylase YP_001848674.1 401317 D 216594 CDS YP_001848675.1 183980384 6224601 complement(402310..403716) 1 NC_010612.1 function unknown; possibly ion channel involved in transport of chloride across the membrane; hypothetical protein 403716 6224601 MMAR_0353 Mycobacterium marinum M hypothetical protein YP_001848675.1 402310 R 216594 CDS YP_001848676.1 183980385 6224602 403853..404839 1 NC_010612.1 hypothetical protein 404839 6224602 MMAR_0354 Mycobacterium marinum M hypothetical protein YP_001848676.1 403853 D 216594 CDS YP_001848677.1 183980386 6224603 404839..405474 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 405474 6224603 MMAR_0355 Mycobacterium marinum M TetR family transcriptional regulator YP_001848677.1 404839 D 216594 CDS YP_001848678.1 183980387 6224604 405619..406551 1 NC_010612.1 hypothetical protein 406551 6224604 MMAR_0356 Mycobacterium marinum M hypothetical protein YP_001848678.1 405619 D 216594 CDS YP_001848679.1 183980388 6224605 406565..407506 1 NC_010612.1 O-methyltransferase 407506 6224605 MMAR_0357 Mycobacterium marinum M O-methyltransferase YP_001848679.1 406565 D 216594 CDS YP_001848680.1 183980389 6224606 407506..408441 1 NC_010612.1 O-methyltransferase 408441 6224606 MMAR_0358 Mycobacterium marinum M O-methyltransferase YP_001848680.1 407506 D 216594 CDS YP_001848681.1 183980390 6224607 408591..410075 1 NC_010612.1 function unknown, probably involved in cellular metabolism [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; aldehyde dehydrogenase (NAD+) dependent 410075 6224607 MMAR_0359 Mycobacterium marinum M aldehyde dehydrogenase (NAD+) dependent YP_001848681.1 408591 D 216594 CDS YP_001848682.1 183980391 6224608 410148..411008 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 411008 6224608 MMAR_0360 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001848682.1 410148 D 216594 CDS YP_001848683.1 183980392 6224609 411013..411981 1 NC_010612.1 possibly binds NADP and acts through a one-electron transfer process. quinones are supposed to be the best substrates. may act in the detoxification of xenobiotics [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone oxidoreductase 411981 6224609 MMAR_0361 Mycobacterium marinum M quinone oxidoreductase YP_001848683.1 411013 D 216594 CDS YP_001848684.1 183980393 6224610 complement(412063..412443) 1 NC_010612.1 hypothetical protein 412443 6224610 MMAR_0362 Mycobacterium marinum M hypothetical protein YP_001848684.1 412063 R 216594 CDS YP_001848685.1 183980394 6224611 complement(412445..413020) 1 NC_010612.1 hypothetical protein 413020 6224611 MMAR_0363 Mycobacterium marinum M hypothetical protein YP_001848685.1 412445 R 216594 CDS YP_001848686.1 183980395 6224612 413350..413568 1 NC_010612.1 hypothetical protein 413568 6224612 MMAR_0364 Mycobacterium marinum M hypothetical protein YP_001848686.1 413350 D 216594 CDS YP_001848687.1 183980396 6224613 413629..416613 1 NC_010612.1 involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase transcriptional regulatory protein PknK_2 416613 pknK_2 6224613 pknK_2 Mycobacterium marinum M serine/threonine-protein kinase transcriptional regulatory protein PknK_2 YP_001848687.1 413629 D 216594 CDS YP_001848688.1 183980397 6224614 416727..419777 1 NC_010612.1 involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase transcriptional regulatory protein PknK_3 419777 pknK_3 6224614 pknK_3 Mycobacterium marinum M serine/threonine-protein kinase transcriptional regulatory protein PknK_3 YP_001848688.1 416727 D 216594 CDS YP_001848689.1 183980398 6224615 complement(419959..420684) 1 NC_010612.1 function unknown; probably involved in lipid metabolism; thioesterase 420684 6224615 MMAR_0367 Mycobacterium marinum M thioesterase YP_001848689.1 419959 R 216594 CDS YP_001848690.1 183980399 6224616 complement(420690..430259) 1 NC_010612.1 function unknown but contains 3 modules for the potential synthesis of a tripeptide; peptide synthetase Nrp (peptide synthase) 430259 6224616 MMAR_0368 Mycobacterium marinum M peptide synthetase Nrp (peptide synthase) YP_001848690.1 420690 R 216594 CDS YP_001848691.1 183980400 6224617 complement(430989..432758) 1 NC_010612.1 PE family protein 432758 6224617 MMAR_0369 Mycobacterium marinum M PE family protein YP_001848691.1 430989 R 216594 CDS YP_001848692.1 183980401 6224618 complement(433165..434817) 1 NC_010612.1 PE family protein 434817 6224618 MMAR_0370 Mycobacterium marinum M PE family protein YP_001848692.1 433165 R 216594 CDS YP_001848693.1 183980402 6224619 complement(434987..436735) 1 NC_010612.1 PE family protein 436735 6224619 MMAR_0371 Mycobacterium marinum M PE family protein YP_001848693.1 434987 R 216594 CDS YP_001848694.1 183980403 6224620 complement(436835..438487) 1 NC_010612.1 PE family protein 438487 6224620 MMAR_0372 Mycobacterium marinum M PE family protein YP_001848694.1 436835 R 216594 CDS YP_001848695.1 183980404 6224621 complement(438612..439442) 1 NC_010612.1 involved in signal transduction (via dephosphorylation). can dephosphorylated in vitro the phosphotyrosine residue of myelin basic protein (MBP) at ph 7.0. could be involved in virulence by interfering with phosphotyrosine-mediated signals in macrophages [catalytic activity: protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate]; phosphotyrosine protein phosphatase PtpB 439442 ptpB 6224621 ptpB Mycobacterium marinum M phosphotyrosine protein phosphatase PtpB YP_001848695.1 438612 R 216594 CDS YP_001848696.1 183980405 6224622 complement(439435..440685) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE2 440685 fadE2 6224622 fadE2 Mycobacterium marinum M acyl-CoA dehydrogenase FadE2 YP_001848696.1 439435 R 216594 CDS YP_001848697.1 183980406 6224623 440810..441688 1 NC_010612.1 hypothetical protein 441688 6224623 MMAR_0375 Mycobacterium marinum M hypothetical protein YP_001848697.1 440810 D 216594 CDS YP_001848698.1 183980407 6224624 441754..442224 1 NC_010612.1 hypothetical protein 442224 6224624 MMAR_0376 Mycobacterium marinum M hypothetical protein YP_001848698.1 441754 D 216594 CDS YP_001848699.1 183980408 6224625 442468..443556 1 NC_010612.1 the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH]; NAD(P) transhydrogenase PntA 443556 pntAa 6224625 pntAa Mycobacterium marinum M NAD(P) transhydrogenase PntA YP_001848699.1 442468 D 216594 CDS YP_001848700.1 183980409 6224626 443572..443910 1 NC_010612.1 the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH]; NAD(P) transhydrogenase (subunit alpha) PntAb 443910 pntAb 6224626 pntAb Mycobacterium marinum M NAD(P) transhydrogenase (subunit alpha) PntAb YP_001848700.1 443572 D 216594 CDS YP_001848701.1 183980410 6224627 443907..445331 1 NC_010612.1 the transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH]; NAD(P) transhydrogenasePntB 445331 pntB 6224627 pntB Mycobacterium marinum M NAD(P) transhydrogenasePntB YP_001848701.1 443907 D 216594 CDS YP_001848702.1 183980411 6224628 complement(445374..445499) 1 NC_010612.1 hypothetical protein 445499 6224628 MMAR_0380 Mycobacterium marinum M hypothetical protein YP_001848702.1 445374 R 216594 CDS YP_001848703.1 183980412 6224629 445667..446290 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 446290 6224629 MMAR_0381 Mycobacterium marinum M TetR family transcriptional regulator YP_001848703.1 445667 D 216594 CDS YP_001848704.1 183980413 6224630 complement(446304..447785) 1 NC_010612.1 PE-PGRS family protein 447785 6224630 MMAR_0382 Mycobacterium marinum M PE-PGRS family protein YP_001848704.1 446304 R 216594 CDS YP_001848705.1 183980414 6224631 complement(447995..449485) 1 NC_010612.1 PE family protein 449485 6224631 MMAR_0383 Mycobacterium marinum M PE family protein YP_001848705.1 447995 R 216594 CDS YP_001848706.1 183980415 6224632 complement(449637..451154) 1 NC_010612.1 PE family protein 451154 6224632 MMAR_0384 Mycobacterium marinum M PE family protein YP_001848706.1 449637 R 216594 CDS YP_001848707.1 183980416 6224633 complement(451282..452190) 1 NC_010612.1 hypothetical protein 452190 6224633 MMAR_0385 Mycobacterium marinum M hypothetical protein YP_001848707.1 451282 R 216594 CDS YP_001848708.1 183980417 6224634 452296..453378 1 NC_010612.1 hypothetical protein 453378 6224634 MMAR_0386 Mycobacterium marinum M hypothetical protein YP_001848708.1 452296 D 216594 CDS YP_001848709.1 183980418 6224635 453398..454138 1 NC_010612.1 thought to be involved in lipid biosynthesis [catalytic activity: androstan-3-alpha,17- beta-diol + NAD+ = 17-beta-hydroxyandrostan-3-one + NADH]; 20-beta-hydroxysteroid dehydrogenase FabG3 454138 fabG3 6224635 fabG3 Mycobacterium marinum M 20-beta-hydroxysteroid dehydrogenase FabG3 YP_001848709.1 453398 D 216594 CDS YP_001848710.1 183980419 6224636 454159..455499 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 455499 6224636 MMAR_0388 Mycobacterium marinum M oxidoreductase YP_001848710.1 454159 D 216594 CDS YP_001848711.1 183980420 6224637 complement(455506..456051) 1 NC_010612.1 function unknown. contains TetR_N, bacterial regulatory proteins, TetR family domain. possibly involved in transcriptional mechanism; putative regulatory protein 456051 6224637 MMAR_0389 Mycobacterium marinum M putative regulatory protein YP_001848711.1 455506 R 216594 CDS YP_001848712.1 183980421 6224638 complement(456110..456925) 1 NC_010612.1 hypothetical protein 456925 6224638 MMAR_0390 Mycobacterium marinum M hypothetical protein YP_001848712.1 456110 R 216594 CDS YP_001848713.1 183980422 6224639 complement(456965..457822) 1 NC_010612.1 hypothetical protein 457822 6224639 MMAR_0391 Mycobacterium marinum M hypothetical protein YP_001848713.1 456965 R 216594 CDS YP_001848714.1 183980423 6224640 457915..458805 1 NC_010612.1 hypothetical protein 458805 6224640 MMAR_0392 Mycobacterium marinum M hypothetical protein YP_001848714.1 457915 D 216594 CDS YP_001848715.1 183980424 6224641 458820..459740 1 NC_010612.1 hypothetical protein 459740 6224641 MMAR_0393 Mycobacterium marinum M hypothetical protein YP_001848715.1 458820 D 216594 CDS YP_001848716.1 183980425 6224642 complement(459763..460440) 1 NC_010612.1 hypothetical protein 460440 6224642 MMAR_0394 Mycobacterium marinum M hypothetical protein YP_001848716.1 459763 R 216594 CDS YP_001848717.1 183980426 6224643 complement(460437..461606) 1 NC_010612.1 hypothetical protein 461606 6224643 MMAR_0395 Mycobacterium marinum M hypothetical protein YP_001848717.1 460437 R 216594 CDS YP_001848718.1 183980427 6224644 461708..462877 1 NC_010612.1 acyl-CoA transferase 462877 6224644 MMAR_0396 Mycobacterium marinum M acyl-CoA transferase YP_001848718.1 461708 D 216594 CDS YP_001848719.1 183980428 6224645 463020..463568 1 NC_010612.1 hypothetical protein 463568 6224645 MMAR_0397 Mycobacterium marinum M hypothetical protein YP_001848719.1 463020 D 216594 CDS YP_001848720.1 183980429 6224646 463606..464310 1 NC_010612.1 hypothetical protein 464310 6224646 MMAR_0398 Mycobacterium marinum M hypothetical protein YP_001848720.1 463606 D 216594 CDS YP_001848721.1 183980430 6224647 464307..465515 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 191A3 Cyp191A3 465515 cyp191A3 6224647 cyp191A3 Mycobacterium marinum M cytochrome P450 191A3 Cyp191A3 YP_001848721.1 464307 D 216594 CDS YP_001848722.1 183980431 6224648 465517..466485 1 NC_010612.1 function unknown; probably involved in cellular metabolism; dehydrogenase 466485 6224648 MMAR_0400 Mycobacterium marinum M dehydrogenase YP_001848722.1 465517 D 216594 CDS YP_001848723.1 183980432 6224649 466482..467243 1 NC_010612.1 hypothetical protein 467243 6224649 MMAR_0401 Mycobacterium marinum M hypothetical protein YP_001848723.1 466482 D 216594 CDS YP_001848724.1 183980433 6224650 467240..467974 1 NC_010612.1 short chain dehydrogenase 467974 6224650 MMAR_0402 Mycobacterium marinum M short chain dehydrogenase YP_001848724.1 467240 D 216594 CDS YP_001848725.1 183980434 6224651 467971..469476 1 NC_010612.1 function unknown, probably involved in cellular metabolism; monooxygenase 469476 6224651 MMAR_0403 Mycobacterium marinum M monooxygenase YP_001848725.1 467971 D 216594 CDS YP_001848726.1 183980435 6224652 469473..470414 1 NC_010612.1 function unknown, lipolytic enzyme probably involved in cellular metabolism; esterase LipW 470414 lipW 6224652 lipW Mycobacterium marinum M esterase LipW YP_001848726.1 469473 D 216594 CDS YP_001848727.1 183980436 6224653 complement(470419..471561) 1 NC_010612.1 dehydrogeneses a alcohol (oxido-reduction) [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]; zinc-type alcohol dehydrogenase AdhE 471561 adhE 6224653 adhE Mycobacterium marinum M zinc-type alcohol dehydrogenase AdhE YP_001848727.1 470419 R 216594 CDS YP_001848728.1 183980437 6224654 471564..472037 1 NC_010612.1 hypothetical protein 472037 6224654 MMAR_0406 Mycobacterium marinum M hypothetical protein YP_001848728.1 471564 D 216594 CDS YP_001848729.1 183980438 6224655 472089..472550 1 NC_010612.1 hypothetical protein 472550 6224655 MMAR_0407 Mycobacterium marinum M hypothetical protein YP_001848729.1 472089 D 216594 CDS YP_001848730.1 183980439 6224656 complement(472575..473267) 1 NC_010612.1 possibly involved in transcriptional mechanism; GntR family transcriptional regulator 473267 6224656 MMAR_0408 Mycobacterium marinum M GntR family transcriptional regulator YP_001848730.1 472575 R 216594 CDS YP_001848731.1 183980440 6224657 473427..475076 1 NC_010612.1 function unknown, but involved in lipid degradation; fatty-acid-CoA ligase FadD5 475076 fadD5 6224657 fadD5 Mycobacterium marinum M fatty-acid-CoA ligase FadD5 YP_001848731.1 473427 D 216594 CDS YP_001848732.1 183980441 6224658 475292..476095 1 NC_010612.1 integral membrane protein YrbE1A 476095 yrbE1A 6224658 yrbE1A Mycobacterium marinum M integral membrane protein YrbE1A YP_001848732.1 475292 D 216594 CDS YP_001848733.1 183980442 6224659 476097..476966 1 NC_010612.1 integral membrane protein YrbE1B 476966 yrbE1B 6224659 yrbE1B Mycobacterium marinum M integral membrane protein YrbE1B YP_001848733.1 476097 D 216594 CDS YP_001848734.1 183980443 6224660 476971..478275 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion (entry and survival inside macrophages); MCE-family protein Mce1A 478275 mce1A 6224660 mce1A Mycobacterium marinum M MCE-family protein Mce1A YP_001848734.1 476971 D 216594 CDS YP_001848735.1 183980444 6224661 478272..479312 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce1B 479312 mce1B 6224661 mce1B Mycobacterium marinum M MCE-family protein Mce1B YP_001848735.1 478272 D 216594 CDS YP_001848736.1 183980445 6224662 479309..480874 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce1C 480874 mce1C 6224662 mce1C Mycobacterium marinum M MCE-family protein Mce1C YP_001848736.1 479309 D 216594 CDS YP_001848737.1 183980446 6224663 480871..482478 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce1D 482478 mce1D 6224663 mce1D Mycobacterium marinum M MCE-family protein Mce1D YP_001848737.1 480871 D 216594 CDS YP_001848738.1 183980447 6224664 482475..483701 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE family lipoprotein LprK 483701 lprK 6224664 lprK Mycobacterium marinum M MCE family lipoprotein LprK YP_001848738.1 482475 D 216594 CDS YP_001848739.1 183980448 6224665 483695..485248 1 NC_010612.1 function unknown, but thought involved in host cell invasion; MCE-family protein Mce1F 485248 mce1F 6224665 mce1F Mycobacterium marinum M MCE-family protein Mce1F YP_001848739.1 483695 D 216594 CDS YP_001848740.1 183980449 6224666 485341..486021 1 NC_010612.1 Mce associated membrane protein 486021 6224666 MMAR_0418 Mycobacterium marinum M Mce associated membrane protein YP_001848740.1 485341 D 216594 CDS YP_001848741.1 183980450 6224667 486018..487007 1 NC_010612.1 Mce associated transmembrane protein 487007 6224667 MMAR_0419 Mycobacterium marinum M Mce associated transmembrane protein YP_001848741.1 486018 D 216594 CDS YP_001848742.1 183980451 6224668 487004..487561 1 NC_010612.1 Mce associated protein 487561 6224668 MMAR_0420 Mycobacterium marinum M Mce associated protein YP_001848742.1 487004 D 216594 CDS YP_001848743.1 183980452 6224669 487528..488349 1 NC_010612.1 Mce associated membrane protein 488349 6224669 MMAR_0421 Mycobacterium marinum M Mce associated membrane protein YP_001848743.1 487528 D 216594 CDS YP_001848744.1 183980453 6224670 complement(488417..489562) 1 NC_010612.1 lipoprotein LprO 489562 lprO 6224670 lprO Mycobacterium marinum M lipoprotein LprO YP_001848744.1 488417 R 216594 CDS YP_001848745.1 183980454 6224671 complement(489608..490981) 1 NC_010612.1 transmembrane protein 490981 6224671 MMAR_0423 Mycobacterium marinum M transmembrane protein YP_001848745.1 489608 R 216594 CDS YP_001848746.1 183980455 6224672 complement(491031..491756) 1 NC_010612.1 hypothetical protein 491756 6224672 MMAR_0424 Mycobacterium marinum M hypothetical protein YP_001848746.1 491031 R 216594 CDS YP_001848747.1 183980456 6224673 complement(491956..493383) 1 NC_010612.1 hypothetical protein 493383 6224673 MMAR_0425 Mycobacterium marinum M hypothetical protein YP_001848747.1 491956 R 216594 CDS YP_001848748.1 183980457 6224674 complement(493386..494417) 1 NC_010612.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; RNA polymerase factor sigma-70 494417 sigG 6224674 sigG Mycobacterium marinum M RNA polymerase factor sigma-70 YP_001848748.1 493386 R 216594 CDS YP_001848749.1 183980458 6224675 494479..495318 1 NC_010612.1 function unknown, probably involved in cellular metabolism; lysophospholipase 495318 6224675 MMAR_0427 Mycobacterium marinum M lysophospholipase YP_001848749.1 494479 D 216594 CDS YP_001848750.1 183980459 6224676 495365..496114 1 NC_010612.1 hypothetical protein 496114 6224676 MMAR_0428 Mycobacterium marinum M hypothetical protein YP_001848750.1 495365 D 216594 CDS YP_001848751.1 183980460 6224677 496111..496635 1 NC_010612.1 function unknown, probably involved in a cellular metabolism; hypothetical protein 496635 6224677 MMAR_0429 Mycobacterium marinum M hypothetical protein YP_001848751.1 496111 D 216594 CDS YP_001848752.1 183980461 6224678 496632..498767 1 NC_010612.1 possibly involved in degradation [catalytic activity: hydrolysis of terminal, non-reducing beta-D- glucose residues with release of beta-D-glucose]; beta-glucosidase BglS 498767 bglS 6224678 bglS Mycobacterium marinum M beta-glucosidase BglS YP_001848752.1 496632 D 216594 CDS YP_001848753.1 183980462 6224679 complement(499089..502493) 1 NC_010612.1 PE-PGRS family protein 502493 6224679 MMAR_0431 Mycobacterium marinum M PE-PGRS family protein YP_001848753.1 499089 R 216594 CDS YP_001848754.1 183980463 6224680 complement(502719..504413) 1 NC_010612.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 504413 ilvD 6224680 ilvD Mycobacterium marinum M dihydroxy-acid dehydratase YP_001848754.1 502719 R 216594 CDS YP_001848755.1 183980464 6224681 504553..504843 1 NC_010612.1 hypothetical protein 504843 6224681 MMAR_0433 Mycobacterium marinum M hypothetical protein YP_001848755.1 504553 D 216594 CDS YP_001848756.1 183980465 6224682 504961..506217 1 NC_010612.1 function unknown, possibly involved in transport of drug across the membrane; integral membrane protein 506217 6224682 MMAR_0434 Mycobacterium marinum M integral membrane protein YP_001848756.1 504961 D 216594 CDS YP_001848757.1 183980466 6224683 506337..507362 1 NC_010612.1 secretory protein 507362 6224683 MMAR_0435 Mycobacterium marinum M secretory protein YP_001848757.1 506337 D 216594 CDS YP_001848758.1 183980467 6224684 507560..508156 1 NC_010612.1 possibly involved in transcriptional mechanism; transcriptional regulatory protein 508156 6224684 MMAR_0436 Mycobacterium marinum M transcriptional regulatory protein YP_001848758.1 507560 D 216594 CDS YP_001848759.1 183980468 6224685 508143..510380 1 NC_010612.1 function unknown; probably involved in cellular metabolism; oxidoreductase 510380 6224685 MMAR_0437 Mycobacterium marinum M oxidoreductase YP_001848759.1 508143 D 216594 CDS YP_001848760.1 183980469 6224686 complement(510437..512431) 1 NC_010612.1 function unknown, hydrolyzes peptides and/or proteins; zinc metalloprotease 512431 6224686 MMAR_0438 Mycobacterium marinum M zinc metalloprotease YP_001848760.1 510437 R 216594 CDS YP_001848761.1 183980470 6224687 512474..513121 1 NC_010612.1 hypothetical protein 513121 6224687 MMAR_0439 Mycobacterium marinum M hypothetical protein YP_001848761.1 512474 D 216594 CDS YP_001848762.1 183980471 6224688 513118..513807 1 NC_010612.1 transmembrane protein 513807 6224688 MMAR_0440 Mycobacterium marinum M transmembrane protein YP_001848762.1 513118 D 216594 CDS YP_001848763.1 183980472 6224689 complement(513794..514333) 1 NC_010612.1 hypothetical protein 514333 6224689 MMAR_0441 Mycobacterium marinum M hypothetical protein YP_001848763.1 513794 R 216594 CDS YP_001848764.1 183980473 6224690 complement(514330..517347) 1 NC_010612.1 function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL11 517347 mmpL11 6224690 mmpL11 Mycobacterium marinum M transmembrane transport protein MmpL11 YP_001848764.1 514330 R 216594 CDS YP_001848765.1 183980474 6224691 517702..518211 1 NC_010612.1 exported protein 518211 6224691 MMAR_0443 Mycobacterium marinum M exported protein YP_001848765.1 517702 D 216594 CDS YP_001848766.1 183980475 6224692 complement(518213..519430) 1 NC_010612.1 transmembrane protein 519430 6224692 MMAR_0444 Mycobacterium marinum M transmembrane protein YP_001848766.1 518213 R 216594 CDS YP_001848767.1 183980476 6224693 519613..520782 1 NC_010612.1 transmembrane protein 520782 6224693 MMAR_0445 Mycobacterium marinum M transmembrane protein YP_001848767.1 519613 D 216594 CDS YP_001848768.1 183980477 6224694 complement(520843..523725) 1 NC_010612.1 function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL3 523725 mmpL3 6224694 mmpL3 Mycobacterium marinum M transmembrane transport protein MmpL3 YP_001848768.1 520843 R 216594 CDS YP_001848769.1 183980478 6224695 complement(523831..524568) 1 NC_010612.1 hypothetical protein 524568 6224695 MMAR_0447 Mycobacterium marinum M hypothetical protein YP_001848769.1 523831 R 216594 CDS YP_001848770.1 183980479 6224696 complement(524606..525514) 1 NC_010612.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 525514 trmB 6224696 trmB Mycobacterium marinum M tRNA (guanine-N(7)-)-methyltransferase YP_001848770.1 524606 R 216594 CDS YP_001848771.1 183980480 6224697 525604..526716 1 NC_010612.1 hypothetical protein 526716 6224697 MMAR_0449 Mycobacterium marinum M hypothetical protein YP_001848771.1 525604 D 216594 CDS YP_001848772.1 183980481 6224698 526713..528266 1 NC_010612.1 hypothetical protein 528266 6224698 MMAR_0450 Mycobacterium marinum M hypothetical protein YP_001848772.1 526713 D 216594 CDS YP_001848773.1 183980482 6224699 528469..530298 1 NC_010612.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 530298 pckA 6224699 pckA Mycobacterium marinum M phosphoenolpyruvate carboxykinase YP_001848773.1 528469 D 216594 CDS YP_001848774.1 183980483 6224700 530308..531831 1 NC_010612.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 531831 fadD4 6224700 fadD4 Mycobacterium marinum M long-chain-fatty-acid--CoA ligase YP_001848774.1 530308 D 216594 CDS YP_001848775.1 183980484 6224701 531834..532802 1 NC_010612.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_4 532802 echA8_4 6224701 echA8_4 Mycobacterium marinum M enoyl-CoA hydratase, EchA8_4 YP_001848775.1 531834 D 216594 CDS YP_001848776.1 183980485 6224702 complement(532837..533238) 1 NC_010612.1 hypothetical protein 533238 6224702 MMAR_0454 Mycobacterium marinum M hypothetical protein YP_001848776.1 532837 R 216594 CDS YP_001848777.1 183980486 6224703 complement(533349..534521) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE3_2 534521 fadE3_2 6224703 fadE3_2 Mycobacterium marinum M acyl-CoA dehydrogenase FadE3_2 YP_001848777.1 533349 R 216594 CDS YP_001848778.1 183980487 6224704 534577..535584 1 NC_010612.1 hypothetical protein 535584 6224704 MMAR_0456 Mycobacterium marinum M hypothetical protein YP_001848778.1 534577 D 216594 CDS YP_001848779.1 183980488 6224706 536820..538121 1 NC_010612.1 hypothetical protein 538121 6224706 MMAR_0459 Mycobacterium marinum M hypothetical protein YP_001848779.1 536820 D 216594 CDS YP_001848780.1 183980489 6224707 538398..539141 1 NC_010612.1 hypothetical protein 539141 6224707 MMAR_0460 Mycobacterium marinum M hypothetical protein YP_001848780.1 538398 D 216594 CDS YP_001848781.1 183980490 6224708 539138..540484 1 NC_010612.1 hypothetical protein 540484 6224708 MMAR_0461 Mycobacterium marinum M hypothetical protein YP_001848781.1 539138 D 216594 CDS YP_001848782.1 183980491 6224709 540486..541004 1 NC_010612.1 hypothetical protein 541004 6224709 MMAR_0462 Mycobacterium marinum M hypothetical protein YP_001848782.1 540486 D 216594 CDS YP_001848783.1 183980492 6224710 541118..542338 1 NC_010612.1 function unknown, lipolytic enzyme probably involved in cellular metabolism; esterase LipC 542338 lipC 6224710 lipC Mycobacterium marinum M esterase LipC YP_001848783.1 541118 D 216594 CDS YP_001848784.1 183980493 6224711 542383..543822 1 NC_010612.1 hypothetical protein 543822 6224711 MMAR_0464 Mycobacterium marinum M hypothetical protein YP_001848784.1 542383 D 216594 CDS YP_001848785.1 183980494 6224712 543819..544601 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 544601 echA1 6224712 echA1 Mycobacterium marinum M enoyl-CoA hydratase YP_001848785.1 543819 D 216594 CDS YP_001848786.1 183980495 6224713 544700..546187 1 NC_010612.1 function unknown, but involved in lipid degradation; long-chain-fatty-acid-CoA ligase 546187 6224713 MMAR_0466 Mycobacterium marinum M long-chain-fatty-acid-CoA ligase YP_001848786.1 544700 D 216594 CDS YP_001848787.1 183980496 6224714 546184..546480 1 NC_010612.1 hypothetical protein 546480 6224714 MMAR_0467 Mycobacterium marinum M hypothetical protein YP_001848787.1 546184 D 216594 CDS YP_001848788.1 183980497 6224715 547031..548785 1 NC_010612.1 function unknown, but involvement in lipid degradation; fatty-acid-CoA ligase 548785 6224715 MMAR_0468 Mycobacterium marinum M fatty-acid-CoA ligase YP_001848788.1 547031 D 216594 CDS YP_001848789.1 183980498 6224716 548897..553561 1 NC_010612.1 involved in peptide synthesis and/or lipid metabolism; peptide synthetase 553561 6224716 MMAR_0469 Mycobacterium marinum M peptide synthetase YP_001848789.1 548897 D 216594 CDS YP_001848790.1 183980499 6224717 complement(553639..554259) 1 NC_010612.1 possibly involved in transcriptional mechanism; transcriptional regulatory protein 554259 6224717 MMAR_0470 Mycobacterium marinum M transcriptional regulatory protein YP_001848790.1 553639 R 216594 CDS YP_001848791.1 183980500 6224718 554570..555385 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 555385 6224718 MMAR_0471 Mycobacterium marinum M enoyl-CoA hydratase YP_001848791.1 554570 D 216594 CDS YP_001848792.1 183980501 6224719 complement(555450..556916) 1 NC_010612.1 thought to oxidize a wide variety of aliphatic and aromatic aldehydes; aldehyde dehydrogenase 556916 6224719 MMAR_0472 Mycobacterium marinum M aldehyde dehydrogenase YP_001848792.1 555450 R 216594 CDS YP_001848793.1 183980502 6224720 complement(556961..557728) 1 NC_010612.1 causes methylation; methyltransferase 557728 6224720 MMAR_0473 Mycobacterium marinum M methyltransferase YP_001848793.1 556961 R 216594 CDS YP_001848794.1 183980503 6224721 557784..558947 1 NC_010612.1 function unknown, contains a glycosyltransferase domain (cell envelope biogenesis, outer membrane); glycosyltransferase 558947 6224721 MMAR_0474 Mycobacterium marinum M glycosyltransferase YP_001848794.1 557784 D 216594 CDS YP_001848795.1 183980504 6224722 complement(558957..560756) 1 NC_010612.1 transmembrane protein 560756 6224722 MMAR_0475 Mycobacterium marinum M transmembrane protein YP_001848795.1 558957 R 216594 CDS YP_001848796.1 183980505 6224723 complement(560767..562047) 1 NC_010612.1 hypothetical protein 562047 6224723 MMAR_0476 Mycobacterium marinum M hypothetical protein YP_001848796.1 560767 R 216594 CDS YP_001848797.1 183980506 6224724 562227..563393 1 NC_010612.1 function unknown, probably involved in cellular metabolism; integral membrane acyltransferase 563393 6224724 MMAR_0477 Mycobacterium marinum M integral membrane acyltransferase YP_001848797.1 562227 D 216594 CDS YP_001848798.1 183980507 6224725 complement(563405..565432) 1 NC_010612.1 function unknown. has fibronectin-binding activity (could thus mediate bacterial attachment to host cells). thought to be expressed during infection; PE-PGRS family protein 565432 6224725 MMAR_0478 Mycobacterium marinum M PE-PGRS family protein YP_001848798.1 563405 R 216594 CDS YP_001848799.1 183980508 6224726 complement(565698..565994) 1 NC_010612.1 hypothetical protein 565994 6224726 MMAR_0479 Mycobacterium marinum M hypothetical protein YP_001848799.1 565698 R 216594 CDS YP_001848800.1 183980509 6224727 complement(565995..566288) 1 NC_010612.1 hypothetical protein 566288 6224727 MMAR_0480 Mycobacterium marinum M hypothetical protein YP_001848800.1 565995 R 216594 CDS YP_001848801.1 183980510 6224728 complement(566639..566908) 1 NC_010612.1 hypothetical protein 566908 6224728 MMAR_0481 Mycobacterium marinum M hypothetical protein YP_001848801.1 566639 R 216594 CDS YP_001848802.1 183980511 6224729 complement(566893..568008) 1 NC_010612.1 hypothetical protein 568008 6224729 MMAR_0482 Mycobacterium marinum M hypothetical protein YP_001848802.1 566893 R 216594 CDS YP_001848803.1 183980512 6224730 complement(568011..568337) 1 NC_010612.1 hypothetical protein 568337 6224730 MMAR_0483 Mycobacterium marinum M hypothetical protein YP_001848803.1 568011 R 216594 CDS YP_001848804.1 183980513 6224731 complement(568627..569241) 1 NC_010612.1 hypothetical protein 569241 6224731 MMAR_0484 Mycobacterium marinum M hypothetical protein YP_001848804.1 568627 R 216594 CDS YP_001848805.1 183980514 6224733 complement(571687..572736) 1 NC_010612.1 PE-PGRS family protein 572736 6224733 MMAR_5555 Mycobacterium marinum M PE-PGRS family protein YP_001848805.1 571687 R 216594 CDS YP_001848806.1 183980515 6224734 complement(572917..573897) 1 NC_010612.1 enzymatic activity is not yet known [catalytic activity: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol]; phosphotriesterase PHP 573897 php 6224734 php Mycobacterium marinum M phosphotriesterase PHP YP_001848806.1 572917 R 216594 CDS YP_001848807.1 183980516 6224735 574239..575945 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE4 575945 fadE4 6224735 fadE4 Mycobacterium marinum M acyl-CoA dehydrogenase FadE4 YP_001848807.1 574239 D 216594 CDS YP_001848808.1 183980517 6224736 576044..576715 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 576715 6224736 MMAR_0489 Mycobacterium marinum M TetR family transcriptional regulator YP_001848808.1 576044 D 216594 CDS YP_001848809.1 183980518 6224737 complement(576837..578213) 1 NC_010612.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinate-semialdehyde dehydrogenase 578213 gabD1 6224737 gabD1 Mycobacterium marinum M succinate-semialdehyde dehydrogenase YP_001848809.1 576837 R 216594 CDS YP_001848810.1 183980519 6224738 578650..579834 1 NC_010612.1 PPE family protein 579834 6224738 MMAR_0491 Mycobacterium marinum M PPE family protein YP_001848810.1 578650 D 216594 CDS YP_001848811.1 183980520 6224739 580024..582498 1 NC_010612.1 PE-PGRS family protein 582498 6224739 MMAR_0492 Mycobacterium marinum M PE-PGRS family protein YP_001848811.1 580024 D 216594 CDS YP_001848812.1 183980521 6224740 complement(582580..584004) 1 NC_010612.1 hypothetical protein 584004 6224740 MMAR_0493 Mycobacterium marinum M hypothetical protein YP_001848812.1 582580 R 216594 CDS YP_001848813.1 183980522 6224741 complement(584129..584917) 1 NC_010612.1 glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols [catalytic activity: a glycerophosphodiester + H(2)O = an alcohol + SN-glycerol 3- phosphate]; glycerophosphoryl diester phosphodiesterase 584917 glpQ2 6224741 glpQ2 Mycobacterium marinum M glycerophosphoryl diester phosphodiesterase YP_001848813.1 584129 R 216594 CDS YP_001848814.1 183980523 6224742 585057..585614 1 NC_010612.1 hypothetical protein 585614 6224742 MMAR_0495 Mycobacterium marinum M hypothetical protein YP_001848814.1 585057 D 216594 CDS YP_001848815.1 183980524 6224743 complement(585618..589796) 1 NC_010612.1 transmembrane protein 589796 6224743 MMAR_0496 Mycobacterium marinum M transmembrane protein YP_001848815.1 585618 R 216594 CDS YP_001848816.1 183980525 6224744 complement(589885..590058) 1 NC_010612.1 small secreted protein 590058 6224744 MMAR_0497 Mycobacterium marinum M small secreted protein YP_001848816.1 589885 R 216594 CDS YP_001848817.1 183980526 6224745 complement(590127..590384) 1 NC_010612.1 putative small secreted protein 590384 6224745 MMAR_0498 Mycobacterium marinum M putative small secreted protein YP_001848817.1 590127 R 216594 CDS YP_001848818.1 183980527 6224746 590488..591681 1 NC_010612.1 lipoprotein LpqI 591681 lpqI 6224746 lpqI Mycobacterium marinum M lipoprotein LpqI YP_001848818.1 590488 D 216594 CDS YP_001848819.1 183980528 6224747 591768..592394 1 NC_010612.1 possibly involved in transcriptional mechanism; TetR family transcriptional regulator 592394 6224747 MMAR_0500 Mycobacterium marinum M TetR family transcriptional regulator YP_001848819.1 591768 D 216594 CDS YP_001848820.1 183980529 6224748 592522..593826 1 NC_010612.1 function unknown, possibly ion channel involved in transport of chloride across the membrane; transmembrane protein 593826 6224748 MMAR_0501 Mycobacterium marinum M transmembrane protein YP_001848820.1 592522 D 216594 CDS YP_001848821.1 183980530 6224749 complement(593838..594689) 1 NC_010612.1 hypothetical protein 594689 6224749 MMAR_0502 Mycobacterium marinum M hypothetical protein YP_001848821.1 593838 R 216594 CDS YP_001848822.1 183980531 6224750 complement(594708..596072) 1 NC_010612.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 596072 fabG 6224750 fabG Mycobacterium marinum M 3-ketoacyl-ACP reductase YP_001848822.1 594708 R 216594 CDS YP_001848823.1 183980532 6224751 596242..597567 1 NC_010612.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 597567 fadA2 6224751 fadA2 Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001848823.1 596242 D 216594 CDS YP_001848824.1 183980533 6224752 complement(597865..599700) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE5 599700 fadE5 6224752 fadE5 Mycobacterium marinum M acyl-CoA dehydrogenase FadE5 YP_001848824.1 597865 R 216594 CDS YP_001848825.1 183980534 6224753 600242..600730 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 600730 6224753 MMAR_0506 Mycobacterium marinum M oxidoreductase YP_001848825.1 600242 D 216594 CDS YP_001848826.1 183980535 6224754 600855..601163 1 NC_010612.1 hypothetical protein 601163 6224754 MMAR_0507 Mycobacterium marinum M hypothetical protein YP_001848826.1 600855 D 216594 CDS YP_001848827.1 183980536 6224755 601170..602420 1 NC_010612.1 integral membrane protein 602420 6224755 MMAR_0508 Mycobacterium marinum M integral membrane protein YP_001848827.1 601170 D 216594 CDS YP_001848828.1 183980537 6224756 complement(602461..602619) 1 NC_010612.1 hypothetical protein 602619 6224756 MMAR_0509 Mycobacterium marinum M hypothetical protein YP_001848828.1 602461 R 216594 CDS YP_001848829.1 183980538 6224757 complement(602667..603413) 1 NC_010612.1 catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source; fumarate reductase iron-sulfur subunit 603413 sdhB_1 6224757 sdhB_1 Mycobacterium marinum M fumarate reductase iron-sulfur subunit YP_001848829.1 602667 R 216594 CDS YP_001848830.1 183980539 6224758 complement(603413..605341) 1 NC_010612.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 605341 sdhA 6224758 sdhA Mycobacterium marinum M succinate dehydrogenase flavoprotein subunit YP_001848830.1 603413 R 216594 CDS YP_001848831.1 183980540 6224759 complement(605388..606209) 1 NC_010612.1 could be involved in interconversion of fumarate and succinate (aerobic respiration). this hydrophobic component may be required to anchor the catalytic components of the succinate dehydrogenase complex to the cytoplasmic membrane; succinate dehydrogenase (membrane anchor subunit) 606209 6224759 MMAR_0512 Mycobacterium marinum M succinate dehydrogenase (membrane anchor subunit) YP_001848831.1 605388 R 216594 CDS YP_001848832.1 183980541 6224760 complement(606288..606584) 1 NC_010612.1 In M. tuberculosis this gene is down regulated by HspR|Rv0353; hypothetical protein 606584 6224760 MMAR_0513 Mycobacterium marinum M hypothetical protein YP_001848832.1 606288 R 216594 CDS YP_001848833.1 183980542 6224761 606700..607470 1 NC_010612.1 PEP phosphonomutase 607470 6224761 MMAR_0514 Mycobacterium marinum M PEP phosphonomutase YP_001848833.1 606700 D 216594 CDS YP_001848834.1 183980543 6224762 complement(607545..608003) 1 NC_010612.1 thought to be involved in the initiation step of translation at high temperature. bound to 30S ribosomal subunit. possibly a molecular chaperone. in M. tuberculosis H37Rv seems to be regulated positively by SigE and negatively by HspR; heat shock protein Hsp 608003 hsp 6224762 hsp Mycobacterium marinum M heat shock protein Hsp YP_001848834.1 607545 R 216594 CDS YP_001848835.1 183980544 6224763 608237..610795 1 NC_010612.1 involved in nitrate assimilation (denitrification) (at the second step). this enzyme is a fad flavoprotein that also contains a siroheme and one 2Fe-2S iron-sulfur center [catalytic activity: 3 NAD(P)H + nitrite = 3 NAD(P)+ + NH4OH + H2O.]; nitrite reductase NAD(P)H large subunit 610795 nirB 6224763 nirB Mycobacterium marinum M nitrite reductase NAD(P)H large subunit YP_001848835.1 608237 D 216594 CDS YP_001848836.1 183980545 6224764 610821..611177 1 NC_010612.1 involved in nitrate assimilation (denitrification); required for activity of the reductase [catalytic activity: 3 NAD(P)H + nitrite = 3 NAD(P)+ + NH4OH + H2O.]; nitrite reductase [NAD(P)H] small subunit NirD 611177 nirD 6224764 nirD Mycobacterium marinum M nitrite reductase [NAD(P)H] small subunit NirD YP_001848836.1 610821 D 216594 CDS YP_001848837.1 183980546 6224765 complement(611314..611769) 1 NC_010612.1 hypothetical protein 611769 6224765 MMAR_0518 Mycobacterium marinum M hypothetical protein YP_001848837.1 611314 R 216594 CDS YP_001848838.1 183980547 6224766 complement(611826..612587) 1 NC_010612.1 hypothetical protein 612587 6224766 MMAR_0519 Mycobacterium marinum M hypothetical protein YP_001848838.1 611826 R 216594 CDS YP_001848839.1 183980548 6224767 complement(612578..613729) 1 NC_010612.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; bifunctional uroporphyrinogen-III synthetase/response regulator domain-containing protein 613729 6224767 MMAR_0520 Mycobacterium marinum M bifunctional uroporphyrinogen-III synthetase/response regulator domain-containing protein YP_001848839.1 612578 R 216594 CDS YP_001848840.1 183980549 6224768 complement(613808..615211) 1 NC_010612.1 involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; integral membrane nitrite extrusion protein NarK3 615211 narK3_2 6224768 narK3_2 Mycobacterium marinum M integral membrane nitrite extrusion protein NarK3 YP_001848840.1 613808 R 216594 CDS YP_001848841.1 183980550 6224769 complement(615441..615986) 1 NC_010612.1 confers resistance to aminoglycosides (gentamicin, tobramycin, dibekacin, netilmicin, and 6'-N- ethylnetilmicin); aminoglycoside 2'-N-acetyltransferase Aac 615986 aac 6224769 aac Mycobacterium marinum M aminoglycoside 2'-N-acetyltransferase Aac YP_001848841.1 615441 R 216594 CDS YP_001848842.1 183980551 6224770 complement(616013..616882) 1 NC_010612.1 urea amidolyase-related protein 616882 6224770 MMAR_0523 Mycobacterium marinum M urea amidolyase-related protein YP_001848842.1 616013 R 216594 CDS YP_001848843.1 183980552 6224771 complement(616898..617569) 1 NC_010612.1 hypothetical protein 617569 6224771 MMAR_0524 Mycobacterium marinum M hypothetical protein YP_001848843.1 616898 R 216594 CDS YP_001848844.1 183980553 6224772 complement(617682..618674) 1 NC_010612.1 thought to be involved in iron transport across the membrane (import); periplasmic iron-transport lipoprotein 618674 6224772 MMAR_0525 Mycobacterium marinum M periplasmic iron-transport lipoprotein YP_001848844.1 617682 R 216594 CDS YP_001848845.1 183980554 6224773 618928..620325 1 NC_010612.1 involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; integral membrane nitrite extrusion protein NarU 620325 narU 6224773 narU Mycobacterium marinum M integral membrane nitrite extrusion protein NarU YP_001848845.1 618928 D 216594 CDS YP_001848846.1 183980555 6224774 complement(620326..621588) 1 NC_010612.1 hypothetical protein 621588 6224774 MMAR_0527 Mycobacterium marinum M hypothetical protein YP_001848846.1 620326 R 216594 CDS YP_001848847.1 183980556 6224775 621656..623329 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 623329 fadD2 6224775 fadD2 Mycobacterium marinum M acyl-CoA synthetase YP_001848847.1 621656 D 216594 CDS YP_001848848.1 183980557 6224776 complement(623773..625134) 1 NC_010612.1 hypothetical protein 625134 6224776 MMAR_0529 Mycobacterium marinum M hypothetical protein YP_001848848.1 623773 R 216594 CDS YP_001848849.1 183980558 6224777 complement(625361..627547) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE6 627547 fadE6 6224777 fadE6 Mycobacterium marinum M acyl-CoA dehydrogenase FadE6 YP_001848849.1 625361 R 216594 CDS YP_001848850.1 183980559 6224778 complement(627604..628566) 1 NC_010612.1 involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis [catalytic activity: 3-phosphoglycerate + NAD(+) = 3- phosphohydroxypyruvate + NADH]; D-3-phosphoglycerate dehydrogenase 628566 serA3 6224778 serA3 Mycobacterium marinum M D-3-phosphoglycerate dehydrogenase YP_001848850.1 627604 R 216594 CDS YP_001848851.1 183980560 6224779 complement(628563..629561) 1 NC_010612.1 hypothetical protein 629561 6224779 MMAR_0532 Mycobacterium marinum M hypothetical protein YP_001848851.1 628563 R 216594 CDS YP_001848852.1 183980561 6224780 complement(629698..630306) 1 NC_010612.1 could be involved in transcriptional mechanism; transcriptional regulatory protein 630306 6224780 MMAR_0533 Mycobacterium marinum M transcriptional regulatory protein YP_001848852.1 629698 R 216594 CDS YP_001848853.1 183980562 6224781 630397..630978 1 NC_010612.1 hypothetical protein 630978 6224781 MMAR_0534 Mycobacterium marinum M hypothetical protein YP_001848853.1 630397 D 216594 CDS YP_001848854.1 183980563 6224782 630985..631533 1 NC_010612.1 hypothetical protein 631533 6224782 MMAR_0535 Mycobacterium marinum M hypothetical protein YP_001848854.1 630985 D 216594 CDS YP_001848855.1 183980564 6224783 complement(631487..632143) 1 NC_010612.1 could be involved in transcriptional mechanism; TetR family transcriptional regulator 632143 6224783 MMAR_0536 Mycobacterium marinum M TetR family transcriptional regulator YP_001848855.1 631487 R 216594 CDS YP_001848856.1 183980565 6224784 632268..633170 1 NC_010612.1 hypothetical protein 633170 6224784 MMAR_0537 Mycobacterium marinum M hypothetical protein YP_001848856.1 632268 D 216594 CDS YP_001848857.1 183980566 6224785 633414..634982 1 NC_010612.1 PPE family protein 634982 6224785 MMAR_0538 Mycobacterium marinum M PPE family protein YP_001848857.1 633414 D 216594 CDS YP_001848858.1 183980567 6224786 635001..635906 1 NC_010612.1 O-methyltransferase 635906 6224786 MMAR_0539 Mycobacterium marinum M O-methyltransferase YP_001848858.1 635001 D 216594 CDS YP_001848859.1 183980568 6224787 636034..636183 1 NC_010612.1 hypothetical protein 636183 6224787 MMAR_0540 Mycobacterium marinum M hypothetical protein YP_001848859.1 636034 D 216594 CDS YP_001848860.1 183980569 6224788 636348..638210 1 NC_010612.1 hypothetical protein 638210 6224788 MMAR_0541 Mycobacterium marinum M hypothetical protein YP_001848860.1 636348 D 216594 CDS YP_001848861.1 183980570 6224789 638207..639808 1 NC_010612.1 hypothetical protein 639808 6224789 MMAR_0542 Mycobacterium marinum M hypothetical protein YP_001848861.1 638207 D 216594 CDS YP_001848862.1 183980571 6224790 639805..643806 1 NC_010612.1 hypothetical protein 643806 6224790 MMAR_0543 Mycobacterium marinum M hypothetical protein YP_001848862.1 639805 D 216594 CDS YP_001848863.1 183980572 6224791 643809..644117 1 NC_010612.1 PE family protein 644117 6224791 MMAR_0544 Mycobacterium marinum M PE family protein YP_001848863.1 643809 D 216594 CDS YP_001848864.1 183980573 6224792 644120..645673 1 NC_010612.1 PPE family protein 645673 6224792 MMAR_0545 Mycobacterium marinum M PPE family protein YP_001848864.1 644120 D 216594 CDS YP_001848865.1 183980574 6224793 645710..646003 1 NC_010612.1 EsaT-6 like protein EsxG 646003 esxG 6224793 esxG Mycobacterium marinum M EsaT-6 like protein EsxG YP_001848865.1 645710 D 216594 CDS YP_001848866.1 183980575 6224794 646032..646322 1 NC_010612.1 EsaT-6 like protein EsxH 646322 esxH 6224794 esxH Mycobacterium marinum M EsaT-6 like protein EsxH YP_001848866.1 646032 D 216594 CDS YP_001848867.1 183980576 6224795 646331..647227 1 NC_010612.1 hypothetical protein 647227 6224795 MMAR_0548 Mycobacterium marinum M hypothetical protein YP_001848867.1 646331 D 216594 CDS YP_001848868.1 183980577 6224796 647299..648717 1 NC_010612.1 transmembrane protein 648717 6224796 MMAR_0549 Mycobacterium marinum M transmembrane protein YP_001848868.1 647299 D 216594 CDS YP_001848869.1 183980578 6224797 648714..650138 1 NC_010612.1 thought to have proteolytic activity; membrane-anchored mycosin MycP3 650138 mycP3 6224797 mycP3 Mycobacterium marinum M membrane-anchored mycosin MycP3 YP_001848869.1 648714 D 216594 CDS YP_001848870.1 183980579 6224798 650128..651141 1 NC_010612.1 transmembrane protein 651141 6224798 MMAR_0551 Mycobacterium marinum M transmembrane protein YP_001848870.1 650128 D 216594 CDS YP_001848871.1 183980580 6224799 complement(651128..652348) 1 NC_010612.1 hypothetical protein 652348 6224799 MMAR_0552 Mycobacterium marinum M hypothetical protein YP_001848871.1 651128 R 216594 CDS YP_001848872.1 183980581 6224800 652505..653296 1 NC_010612.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 653296 tam 6224800 tam Mycobacterium marinum M trans-aconitate 2-methyltransferase YP_001848872.1 652505 D 216594 CDS YP_001848873.1 183980582 6224801 complement(653314..654711) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; sulfatase 654711 6224801 MMAR_0554 Mycobacterium marinum M sulfatase YP_001848873.1 653314 R 216594 CDS YP_001848874.1 183980583 6224802 complement(654778..655428) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 655428 6224802 MMAR_0555 Mycobacterium marinum M oxidoreductase YP_001848874.1 654778 R 216594 CDS YP_001848875.1 183980584 6224804 655616..655873 1 NC_010612.1 hypothetical protein 655873 6224804 MMAR_0556 Mycobacterium marinum M hypothetical protein YP_001848875.1 655616 D 216594 CDS YP_001848876.1 183980585 6224805 complement(655857..656339) 1 NC_010612.1 hypothetical protein 656339 6224805 MMAR_0557 Mycobacterium marinum M hypothetical protein YP_001848876.1 655857 R 216594 CDS YP_001848877.1 183980586 6224806 656396..657064 1 NC_010612.1 hypothetical protein 657064 6224806 MMAR_0558 Mycobacterium marinum M hypothetical protein YP_001848877.1 656396 D 216594 CDS YP_001848878.1 183980587 6224807 657170..657826 1 NC_010612.1 hypothetical protein 657826 6224807 MMAR_0559 Mycobacterium marinum M hypothetical protein YP_001848878.1 657170 D 216594 CDS YP_001848879.1 183980588 6224808 complement(657835..658323) 1 NC_010612.1 hypothetical protein 658323 6224808 MMAR_0560 Mycobacterium marinum M hypothetical protein YP_001848879.1 657835 R 216594 CDS YP_001848880.1 183980589 6224809 658401..659630 1 NC_010612.1 hypothetical protein 659630 6224809 MMAR_0561 Mycobacterium marinum M hypothetical protein YP_001848880.1 658401 D 216594 CDS YP_001848881.1 183980590 6224810 659783..661663 1 NC_010612.1 hypothetical protein 661663 6224810 MMAR_0562 Mycobacterium marinum M hypothetical protein YP_001848881.1 659783 D 216594 CDS YP_001848882.1 183980591 6224811 661885..663321 1 NC_010612.1 hypothetical protein 663321 6224811 MMAR_0563 Mycobacterium marinum M hypothetical protein YP_001848882.1 661885 D 216594 CDS YP_001848883.1 183980592 6224812 663389..663775 1 NC_010612.1 hypothetical protein 663775 6224812 MMAR_0564 Mycobacterium marinum M hypothetical protein YP_001848883.1 663389 D 216594 CDS YP_001848884.1 183980593 6224813 complement(663823..664542) 1 NC_010612.1 hypothetical protein 664542 6224813 MMAR_0565 Mycobacterium marinum M hypothetical protein YP_001848884.1 663823 R 216594 CDS YP_001848885.1 183980594 6224814 664606..665625 1 NC_010612.1 hypothetical protein 665625 6224814 MMAR_0566 Mycobacterium marinum M hypothetical protein YP_001848885.1 664606 D 216594 CDS YP_001848886.1 183980595 6224815 665837..666715 1 NC_010612.1 possibly hydrolyzes specific sugar (hydrolyzation of glycosidic bond) and could be involved in exopolysaccharide biosynthesis/degradation. could also have a lytic activity against cell walls; beta-1,3-glucanase 666715 6224815 MMAR_0567 Mycobacterium marinum M beta-1,3-glucanase YP_001848886.1 665837 D 216594 CDS YP_001848887.1 183980596 6224816 666815..667474 1 NC_010612.1 could be involved in the catabolism of catechol to succinate- and acetyl-CoA in the beta-ketoadipate pathway (at the third step) [catalytic activity: 2,5-dihydro-5- oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate]; muconolactone isomerase 667474 6224816 MMAR_0568 Mycobacterium marinum M muconolactone isomerase YP_001848887.1 666815 D 216594 CDS YP_001848888.1 183980597 6224817 667509..669005 1 NC_010612.1 hypothetical protein 669005 6224817 MMAR_0569 Mycobacterium marinum M hypothetical protein YP_001848888.1 667509 D 216594 CDS YP_001848889.1 183980598 6224818 complement(668953..670395) 1 NC_010612.1 phosphorylation of carbohydrates; carbohydrate kinase 670395 6224818 MMAR_0570 Mycobacterium marinum M carbohydrate kinase YP_001848889.1 668953 R 216594 CDS YP_001848890.1 183980599 6224819 complement(670445..671848) 1 NC_010612.1 carbohydrate metabolism; mannitol dehydrogenase 671848 6224819 MMAR_0571 Mycobacterium marinum M mannitol dehydrogenase YP_001848890.1 670445 R 216594 CDS YP_001848891.1 183980600 6224820 672368..673837 1 NC_010612.1 PE-PGRS family protein 673837 6224820 MMAR_0572 Mycobacterium marinum M PE-PGRS family protein YP_001848891.1 672368 D 216594 CDS YP_001848892.1 183980601 6224821 673937..675019 1 NC_010612.1 function unknown but may have hydrolytic activity; hypothetical protein 675019 6224821 MMAR_0573 Mycobacterium marinum M hypothetical protein YP_001848892.1 673937 D 216594 CDS YP_001848893.1 183980602 6224822 complement(675134..676234) 1 NC_010612.1 hypothetical protein 676234 6224822 MMAR_0574 Mycobacterium marinum M hypothetical protein YP_001848893.1 675134 R 216594 CDS YP_001848894.1 183980603 6224823 complement(676332..677102) 1 NC_010612.1 hydrolytic protein 677102 6224823 MMAR_0575 Mycobacterium marinum M hydrolytic protein YP_001848894.1 676332 R 216594 CDS YP_001848895.1 183980604 6224824 complement(677132..679717) 1 NC_010612.1 function unknown; probably involved in cellular metabolism; monooxygenase 679717 6224824 MMAR_0576 Mycobacterium marinum M monooxygenase YP_001848895.1 677132 R 216594 CDS YP_001848896.1 183980605 6224825 complement(679836..681011) 1 NC_010612.1 function unknown; belongs to the major facilitator superfamily (MFS); integral membrane transport protein 681011 6224825 MMAR_0577 Mycobacterium marinum M integral membrane transport protein YP_001848896.1 679836 R 216594 CDS YP_001848897.1 183980606 6224826 681544..682746 1 NC_010612.1 3-dehydroquinate (DHQ) synthase catalyses the formation of dehydroquinate (DHQ) and orthophosphate from 3-deoxy-D-arabino heptulosonic 7 phosphate. this reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids; 3-dehydroquinate synthase 682746 aroB_1 6224826 aroB_1 Mycobacterium marinum M 3-dehydroquinate synthase YP_001848897.1 681544 D 216594 CDS YP_001848898.1 183980607 6224827 682746..683504 1 NC_010612.1 dehydrogenase 683504 6224827 MMAR_0579 Mycobacterium marinum M dehydrogenase YP_001848898.1 682746 D 216594 CDS YP_001848899.1 183980608 6224828 683515..684183 1 NC_010612.1 hydrolase 684183 6224828 MMAR_0580 Mycobacterium marinum M hydrolase YP_001848899.1 683515 D 216594 CDS YP_001848900.1 183980609 6224829 684190..685191 1 NC_010612.1 domain homology to NagC, transcriptional regulator/sugar kinase [transcription / carbohydrate transport and metabolism]; glucose kinase 685191 6224829 MMAR_0581 Mycobacterium marinum M glucose kinase YP_001848900.1 684190 D 216594 CDS YP_001848901.1 183980610 6224830 685188..686297 1 NC_010612.1 function unknown; similarity to cyclitol dehydrogenase from actinoplanes sp. 50/110; dehydrogenase 686297 6224830 MMAR_0582 Mycobacterium marinum M dehydrogenase YP_001848901.1 685188 D 216594 CDS YP_001848902.1 183980611 6224831 686294..687079 1 NC_010612.1 epimerase 687079 6224831 MMAR_0583 Mycobacterium marinum M epimerase YP_001848902.1 686294 D 216594 CDS YP_001848903.1 183980612 6224832 687271..688077 1 NC_010612.1 hypothetical protein 688077 6224832 MMAR_0584 Mycobacterium marinum M hypothetical protein YP_001848903.1 687271 D 216594 CDS YP_001848904.1 183980613 6224833 complement(688162..688371) 1 NC_010612.1 hypothetical protein 688371 6224833 MMAR_0585 Mycobacterium marinum M hypothetical protein YP_001848904.1 688162 R 216594 CDS YP_001848905.1 183980614 6224834 complement(688441..689655) 1 NC_010612.1 hypothetical protein 689655 6224834 MMAR_0586 Mycobacterium marinum M hypothetical protein YP_001848905.1 688441 R 216594 CDS YP_001848906.1 183980615 6224835 690319..691065 1 NC_010612.1 function unknown; probably involved in cellular metabolism; short-chain type dehydrogenase/reductase 691065 6224835 MMAR_0587 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001848906.1 690319 D 216594 CDS YP_001848907.1 183980616 6224836 691118..691279 1 NC_010612.1 hypothetical protein 691279 6224836 MMAR_0588 Mycobacterium marinum M hypothetical protein YP_001848907.1 691118 D 216594 CDS YP_001848908.1 183980617 6224837 691276..691878 1 NC_010612.1 possible phage recombinase; site-specific recombinase PinR 691878 pinR 6224837 pinR Mycobacterium marinum M site-specific recombinase PinR YP_001848908.1 691276 D 216594 CDS YP_001848909.1 183980618 6224838 691875..692183 1 NC_010612.1 hypothetical protein 692183 6224838 MMAR_0590 Mycobacterium marinum M hypothetical protein YP_001848909.1 691875 D 216594 CDS YP_001848910.1 183980619 6224842 complement(693949..695250) 1 NC_010612.1 hypothetical protein 695250 6224842 MMAR_0593 Mycobacterium marinum M hypothetical protein YP_001848910.1 693949 R 216594 CDS YP_001848911.1 183980620 6224843 complement(695247..695909) 1 NC_010612.1 hypothetical protein 695909 6224843 MMAR_0594 Mycobacterium marinum M hypothetical protein YP_001848911.1 695247 R 216594 CDS YP_001848912.1 183980621 6224845 complement(696096..696875) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 696875 6224845 MMAR_0595 Mycobacterium marinum M transcriptional regulatory protein YP_001848912.1 696096 R 216594 CDS YP_001848913.1 183980622 6224846 697088..698422 1 NC_010612.1 integral membrane transport protein 698422 6224846 MMAR_0596 Mycobacterium marinum M integral membrane transport protein YP_001848913.1 697088 D 216594 CDS YP_001848914.1 183980623 6224847 698509..698925 1 NC_010612.1 hypothetical protein 698925 6224847 MMAR_0597 Mycobacterium marinum M hypothetical protein YP_001848914.1 698509 D 216594 CDS YP_001848915.1 183980624 6224848 698949..699617 1 NC_010612.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 699617 pcp 6224848 pcp Mycobacterium marinum M pyrrolidone-carboxylate peptidase YP_001848915.1 698949 D 216594 CDS YP_001848916.1 183980625 6224849 699820..700488 1 NC_010612.1 may be exported; hypothetical protein 700488 6224849 MMAR_0599 Mycobacterium marinum M hypothetical protein YP_001848916.1 699820 D 216594 CDS YP_001848917.1 183980626 6224850 700534..701106 1 NC_010612.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 701106 dcd 6224850 dcd Mycobacterium marinum M deoxycytidine triphosphate deaminase YP_001848917.1 700534 D 216594 CDS YP_001848918.1 183980627 6224851 701196..702881 1 NC_010612.1 hypothetical protein 702881 6224851 MMAR_0601 Mycobacterium marinum M hypothetical protein YP_001848918.1 701196 D 216594 CDS YP_001848919.1 183980628 6224852 703037..704563 1 NC_010612.1 hypothetical protein 704563 6224852 MMAR_0602 Mycobacterium marinum M hypothetical protein YP_001848919.1 703037 D 216594 CDS YP_001848920.1 183980629 6224853 704640..705974 1 NC_010612.1 UDP-glucose dehydrogenase UdgA 705974 udgA 6224853 udgA Mycobacterium marinum M UDP-glucose dehydrogenase UdgA YP_001848920.1 704640 D 216594 CDS YP_001848921.1 183980630 6224854 706036..706791 1 NC_010612.1 hypothetical protein 706791 6224854 MMAR_0604 Mycobacterium marinum M hypothetical protein YP_001848921.1 706036 D 216594 CDS YP_001848922.1 183980631 6224855 706827..707201 1 NC_010612.1 hypothetical protein 707201 6224855 MMAR_0605 Mycobacterium marinum M hypothetical protein YP_001848922.1 706827 D 216594 CDS YP_001848923.1 183980632 6224856 707231..708097 1 NC_010612.1 dTDP-L-rhamnose biosynthesis within the O antigen biosynthesis pathway of lipopolysaccharide biosynthesis [catalytic activity: dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose]; alpha-D-glucose-1-phosphate thymidylyl- transferase, RmlA 708097 rmlA 6224856 rmlA Mycobacterium marinum M alpha-D-glucose-1-phosphate thymidylyl- transferase, RmlA YP_001848923.1 707231 D 216594 CDS YP_001848924.1 183980633 6224857 complement(708134..709567) 1 NC_010612.1 Ortholog of PE_PGRS9; PE-PGRS family protein 709567 6224857 MMAR_0607 Mycobacterium marinum M PE-PGRS family protein YP_001848924.1 708134 R 216594 CDS YP_001848925.1 183980634 6224858 complement(709749..711179) 1 NC_010612.1 PE-PGRS family protein 711179 6224858 MMAR_0608 Mycobacterium marinum M PE-PGRS family protein YP_001848925.1 709749 R 216594 CDS YP_001848926.1 183980635 6224859 711571..714756 1 NC_010612.1 function unknown, member of the mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins; PE-PGRS family protein 714756 6224859 MMAR_0609 Mycobacterium marinum M PE-PGRS family protein YP_001848926.1 711571 D 216594 CDS YP_001848927.1 183980636 6224860 complement(714850..716139) 1 NC_010612.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 716139 aspC 6224860 aspC Mycobacterium marinum M aminotransferase AlaT YP_001848927.1 714850 R 216594 CDS YP_001848928.1 183980637 6224861 complement(716170..719127) 1 NC_010612.1 iron-sulfur-binding reductase 719127 6224861 MMAR_0611 Mycobacterium marinum M iron-sulfur-binding reductase YP_001848928.1 716170 R 216594 CDS YP_001848929.1 183980638 6224862 complement(719257..721710) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 721710 6224862 MMAR_0612 Mycobacterium marinum M transcriptional regulatory protein YP_001848929.1 719257 R 216594 CDS YP_001848930.1 183980639 6224863 721914..722453 1 NC_010612.1 hypothetical protein 722453 6224863 MMAR_0613 Mycobacterium marinum M hypothetical protein YP_001848930.1 721914 D 216594 CDS YP_001848931.1 183980640 6224864 722730..725729 1 NC_010612.1 function unknown function but ortholog in M.tuberculosis induced by isoniazid and ethionamide; membrane protein, IniB 725729 iniB 6224864 iniB Mycobacterium marinum M membrane protein, IniB YP_001848931.1 722730 D 216594 CDS YP_001848932.1 183980641 6224865 725830..727683 1 NC_010612.1 in M. tuberculosis H37Rv this gene is induced by isoniazid (INH) or ethionamide treatment) (see wilson et al., 1999); hypothetical protein 727683 iniA 6224865 iniA Mycobacterium marinum M hypothetical protein YP_001848932.1 725830 D 216594 CDS YP_001848933.1 183980642 6224866 727680..729161 1 NC_010612.1 in M. tuberculosis H37Rv IniC is an isoniazid- inducible gene; isoniazid inductible protein IniC 729161 iniC 6224866 iniC Mycobacterium marinum M isoniazid inductible protein IniC YP_001848933.1 727680 D 216594 CDS YP_001848934.1 183980643 6224867 complement(729166..731004) 1 NC_010612.1 hypothetical protein 731004 6224867 MMAR_0617 Mycobacterium marinum M hypothetical protein YP_001848934.1 729166 R 216594 CDS YP_001848935.1 183980644 6224868 complement(731096..731641) 1 NC_010612.1 hypothetical protein 731641 6224868 MMAR_0618 Mycobacterium marinum M hypothetical protein YP_001848935.1 731096 R 216594 CDS YP_001848936.1 183980645 6224869 complement(731749..732330) 1 NC_010612.1 hypothetical protein 732330 6224869 MMAR_0619 Mycobacterium marinum M hypothetical protein YP_001848936.1 731749 R 216594 CDS YP_001848937.1 183980646 6224870 complement(732367..732936) 1 NC_010612.1 lipoprotein LpqJ 732936 lpqJ 6224870 lpqJ Mycobacterium marinum M lipoprotein LpqJ YP_001848937.1 732367 R 216594 CDS YP_001848938.1 183980647 6224871 complement(733028..733504) 1 NC_010612.1 probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase small chain CoxS_3 733504 coxS_3 6224871 coxS_3 Mycobacterium marinum M carbon monoxyde dehydrogenase small chain CoxS_3 YP_001848938.1 733028 R 216594 CDS YP_001848939.1 183980648 6224872 complement(733497..734384) 1 NC_010612.1 aerobic-type carbon monoxide dehydrogenase subunit CoxM_3 734384 coxM_3 6224872 coxM_3 Mycobacterium marinum M aerobic-type carbon monoxide dehydrogenase subunit CoxM_3 YP_001848939.1 733497 R 216594 CDS YP_001848940.1 183980649 6224873 complement(734381..736711) 1 NC_010612.1 aerobic-type carbon monoxide dehydrogenase subunit CoxL_3 736711 coxL_3 6224873 coxL_3 Mycobacterium marinum M aerobic-type carbon monoxide dehydrogenase subunit CoxL_3 YP_001848940.1 734381 R 216594 CDS YP_001848941.1 183980650 6224874 736871..737419 1 NC_010612.1 hypothetical protein 737419 6224874 MMAR_0624 Mycobacterium marinum M hypothetical protein YP_001848941.1 736871 D 216594 CDS YP_001848942.1 183980651 6224875 complement(737435..737812) 1 NC_010612.1 PE-PGRS family protein 737812 6224875 MMAR_0625 Mycobacterium marinum M PE-PGRS family protein YP_001848942.1 737435 R 216594 CDS YP_001848943.1 183980652 6224876 complement(737973..739403) 1 NC_010612.1 involved in L-asparagine transport; L-asparagine permease AnsP1 739403 ansP1_1 6224876 ansP1_1 Mycobacterium marinum M L-asparagine permease AnsP1 YP_001848943.1 737973 R 216594 CDS YP_001848944.1 183980653 6224877 complement(739684..740505) 1 NC_010612.1 function unknown; domain homology with alkanesulfonate_monoxygenase; monooxygenase 740505 6224877 MMAR_0628 Mycobacterium marinum M monooxygenase YP_001848944.1 739684 R 216594 CDS YP_001848945.1 183980654 6224878 complement(740539..741276) 1 NC_010612.1 function unknown; FabG-like enzyme; dehydrogenase 741276 6224878 MMAR_0629 Mycobacterium marinum M dehydrogenase YP_001848945.1 740539 R 216594 CDS YP_001848946.1 183980655 6224879 741480..742088 1 NC_010612.1 transcriptional regulatory protein 742088 6224879 MMAR_0630 Mycobacterium marinum M transcriptional regulatory protein YP_001848946.1 741480 D 216594 CDS YP_001848947.1 183980656 6224880 742925..744583 1 NC_010612.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 744583 kdpA 6224880 kdpA Mycobacterium marinum M potassium-transporting ATPase subunit A YP_001848947.1 742925 D 216594 CDS YP_001848948.1 183980657 6224881 744583..746664 1 NC_010612.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 746664 kdpB 6224881 kdpB Mycobacterium marinum M potassium-transporting ATPase subunit B YP_001848948.1 744583 D 216594 CDS YP_001848949.1 183980658 6224882 746667..747557 1 NC_010612.1 one of the components of the high-affinity ATP- driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. the C subunit may be involved in assembly of the Kdp complex. [catalytic activity: ATP + H(2)O + K(+)(out) = ADP + phosphate + K(+)(in)]; potassium-transporting ATPase subunit KdpC 747557 kdpC 6224882 kdpC Mycobacterium marinum M potassium-transporting ATPase subunit KdpC YP_001848949.1 746667 D 216594 CDS YP_001848950.1 183980659 6224883 747565..750084 1 NC_010612.1 member of the two-component regulatory system KdpD/KdpE involved in the regulation of the Kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals; two-component system response phosphate sensor kinase, KdpD 750084 kdpD 6224883 kdpD Mycobacterium marinum M two-component system response phosphate sensor kinase, KdpD YP_001848950.1 747565 D 216594 CDS YP_001848951.1 183980660 6224884 750081..750761 1 NC_010612.1 receiver domain of the two-component regulatory system Kdp/KdpE involved in the regulation of the Kdp operon; transcriptional regulatory protein KdpE 750761 kdpE 6224884 kdpE Mycobacterium marinum M transcriptional regulatory protein KdpE YP_001848951.1 750081 D 216594 CDS YP_001848952.1 183980661 6224885 complement(750981..751961) 1 NC_010612.1 hypothetical protein 751961 6224885 MMAR_0636 Mycobacterium marinum M hypothetical protein YP_001848952.1 750981 R 216594 CDS YP_001848953.1 183980662 6224886 752226..754094 1 NC_010612.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 754094 dnaK 6224886 dnaK Mycobacterium marinum M molecular chaperone DnaK YP_001848953.1 752226 D 216594 CDS YP_001848954.1 183980663 6224887 754091..754744 1 NC_010612.1 stimulates, jointly with DnaJ, the ATPase activity of DnaK. helps to release ADP from DnaK thus allowing DnaK to recycle more efficiently. seems to be regulated negatively by HspR; GrpE protein (Hsp-70 cofactor) 754744 grpE 6224887 grpE Mycobacterium marinum M GrpE protein (Hsp-70 cofactor) YP_001848954.1 754091 D 216594 CDS YP_001848955.1 183980664 6224888 754802..755992 1 NC_010612.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 755992 dnaJ 6224888 dnaJ Mycobacterium marinum M chaperone protein DnaJ YP_001848955.1 754802 D 216594 CDS YP_001848956.1 183980665 6224889 755993..756379 1 NC_010612.1 involved in transcriptional regulation (repression) of heat shock proteins E.G. DnaK, GrpE, DnaJ1. binds to three inverted repeats (IR1-IR3) in the promoter region of the DnaK operon. induction: by heat shock; heat shock protein transcriptional repressor HspR 756379 hspR 6224889 hspR Mycobacterium marinum M heat shock protein transcriptional repressor HspR YP_001848956.1 755993 D 216594 CDS YP_001848957.1 183980666 6224890 complement(756407..763618) 1 NC_010612.1 PPE family protein 763618 6224890 MMAR_0641 Mycobacterium marinum M PPE family protein YP_001848957.1 756407 R 216594 CDS YP_001848958.1 183980667 6224891 complement(763949..774499) 1 NC_010612.1 PPE family protein 774499 6224891 MMAR_0642 Mycobacterium marinum M PPE family protein YP_001848958.1 763949 R 216594 CDS YP_001848959.1 183980668 6224892 complement(775707..776597) 1 NC_010612.1 possible carbohydrate transport and metabolism; hypothetical protein 776597 6224892 MMAR_0643 Mycobacterium marinum M hypothetical protein YP_001848959.1 775707 R 216594 CDS YP_001848960.1 183980669 6224893 complement(776672..777853) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; monooxygenase 777853 6224893 MMAR_0644 Mycobacterium marinum M monooxygenase YP_001848960.1 776672 R 216594 CDS YP_001848961.1 183980670 6224894 778180..780726 1 NC_010612.1 ATPase subunit of an intracellular ATP-dependent protease. in M. tuberculosis H37Rv it is regulated positively by SigH and negatively by HspR; endopeptidase ATP binding protein (chain B) ClpB 780726 clpB 6224894 clpB Mycobacterium marinum M endopeptidase ATP binding protein (chain B) ClpB YP_001848961.1 778180 D 216594 CDS YP_001848962.1 183980671 6224895 complement(780723..781553) 1 NC_010612.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8 781553 echA8_1 6224895 echA8_1 Mycobacterium marinum M enoyl-CoA hydratase, EchA8 YP_001848962.1 780723 R 216594 CDS YP_001848963.1 183980672 6224896 781912..782766 1 NC_010612.1 hypothetical protein 782766 6224896 MMAR_0647 Mycobacterium marinum M hypothetical protein YP_001848963.1 781912 D 216594 CDS YP_001848964.1 183980673 6224897 782811..783584 1 NC_010612.1 function unknown, but possibly involvement in lipid metabolism; ketoacyl reductase 783584 6224897 MMAR_0648 Mycobacterium marinum M ketoacyl reductase YP_001848964.1 782811 D 216594 CDS YP_001848965.1 183980674 6224898 783571..784110 1 NC_010612.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 784110 pyrE 6224898 pyrE Mycobacterium marinum M orotate phosphoribosyltransferase YP_001848965.1 783571 D 216594 CDS YP_001848966.1 183980675 6224899 784121..785014 1 NC_010612.1 hypothetical protein 785014 6224899 MMAR_0650 Mycobacterium marinum M hypothetical protein YP_001848966.1 784121 D 216594 CDS YP_001848967.1 183980676 6224900 785011..785655 1 NC_010612.1 possibly causes methylation of RNA; RNA methyltransferase 785655 6224900 MMAR_0651 Mycobacterium marinum M RNA methyltransferase YP_001848967.1 785011 D 216594 CDS YP_001848968.1 183980677 6224901 complement(785764..785979) 1 NC_010612.1 thought to be involved in protein transport (export); protein transport protein SecE2 785979 secE2 6224901 secE2 Mycobacterium marinum M protein transport protein SecE2 YP_001848968.1 785764 R 216594 CDS YP_001848969.1 183980678 6224902 complement(785997..786962) 1 NC_010612.1 possibly involved in transcriptional mechanism; LysR family transcriptional regulator 786962 6224902 MMAR_0653 Mycobacterium marinum M LysR family transcriptional regulator YP_001848969.1 785997 R 216594 CDS YP_001848970.1 183980679 6224903 786987..788150 1 NC_010612.1 hypothetical protein 788150 6224903 MMAR_0654 Mycobacterium marinum M hypothetical protein YP_001848970.1 786987 D 216594 CDS YP_001848971.1 183980680 6224904 788211..789101 1 NC_010612.1 function unknown; probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase medium chain CoxM 789101 coxM 6224904 coxM Mycobacterium marinum M carbon monoxyde dehydrogenase medium chain CoxM YP_001848971.1 788211 D 216594 CDS YP_001848972.1 183980681 6224905 789101..789583 1 NC_010612.1 function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase small chain CoxS 789583 coxS 6224905 coxS Mycobacterium marinum M carbon monoxyde dehydrogenase small chain CoxS YP_001848972.1 789101 D 216594 CDS YP_001848973.1 183980682 6224906 789580..791970 1 NC_010612.1 function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase large chain CoxL 791970 coxL 6224906 coxL Mycobacterium marinum M carbon monoxyde dehydrogenase large chain CoxL YP_001848973.1 789580 D 216594 CDS YP_001848974.1 183980683 6224907 791980..792864 1 NC_010612.1 hypothetical protein 792864 6224907 MMAR_0658 Mycobacterium marinum M hypothetical protein YP_001848974.1 791980 D 216594 CDS YP_001848975.1 183980684 6224908 792861..793451 1 NC_010612.1 hypothetical protein 793451 6224908 MMAR_0659 Mycobacterium marinum M hypothetical protein YP_001848975.1 792861 D 216594 CDS YP_001848976.1 183980685 6224909 793452..794330 1 NC_010612.1 function unknown, probably involved in cellular metabolism; membrane oxidoreductase 794330 6224909 MMAR_0660 Mycobacterium marinum M membrane oxidoreductase YP_001848976.1 793452 D 216594 CDS YP_001848977.1 183980686 6224910 794344..795018 1 NC_010612.1 function unknown, probably involved in cellular metabolism; membrane oxidoreductase 795018 6224910 MMAR_0661 Mycobacterium marinum M membrane oxidoreductase YP_001848977.1 794344 D 216594 CDS YP_001848978.1 183980687 6224911 795025..796230 1 NC_010612.1 von Willebrand factor type A domain-containing protein 796230 6224911 MMAR_0662 Mycobacterium marinum M von Willebrand factor type A domain-containing protein YP_001848978.1 795025 D 216594 CDS YP_001848979.1 183980688 6224912 complement(796233..797006) 1 NC_010612.1 catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit 797006 eutC 6224912 eutC Mycobacterium marinum M ethanolamine ammonia-lyase small subunit YP_001848979.1 796233 R 216594 CDS YP_001848980.1 183980689 6224913 complement(797003..798412) 1 NC_010612.1 ethanolamine catabolism. catalyzes the conversion of ethanolamine to acetaldehyde in the presence of coenzyme B12 or adenosylcobalamin (AdoCbl); ethanolamine ammonia-lyase large subunit, EutB 798412 eutB 6224913 eutB Mycobacterium marinum M ethanolamine ammonia-lyase large subunit, EutB YP_001848980.1 797003 R 216594 CDS YP_001848981.1 183980690 6224914 complement(798409..799860) 1 NC_010612.1 thought to be involved in cationic amino acid transport across the membrane. responsible for the translocation of the substrate across the membrane; ethanolamine transporter 799860 6224914 MMAR_0665 Mycobacterium marinum M ethanolamine transporter YP_001848981.1 798409 R 216594 CDS YP_001848982.1 183980691 6224915 800337..801662 1 NC_010612.1 involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]; membrane-anchored adenylyl cyclase Cya 801662 cya_1 6224915 cya_1 Mycobacterium marinum M membrane-anchored adenylyl cyclase Cya YP_001848982.1 800337 D 216594 CDS YP_001848983.1 183980692 6224916 801761..802876 1 NC_010612.1 glycosyl hydrolase 802876 6224916 MMAR_0667 Mycobacterium marinum M glycosyl hydrolase YP_001848983.1 801761 D 216594 CDS YP_001848984.1 183980693 6224917 complement(802865..803557) 1 NC_010612.1 transmembrane protein 803557 6224917 MMAR_0668 Mycobacterium marinum M transmembrane protein YP_001848984.1 802865 R 216594 CDS YP_001848985.1 183980694 6224918 803658..804692 1 NC_010612.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 804692 fba 6224918 fba Mycobacterium marinum M fructose-bisphosphate aldolase YP_001848985.1 803658 D 216594 CDS YP_001848986.1 183980695 6224919 complement(804824..806212) 1 NC_010612.1 thought to be involved in Mg2+ transport. responsible for the translocation of the substrate across the membrane; Mg2+ transport transmembrane protein MgtE 806212 mgtE 6224919 mgtE Mycobacterium marinum M Mg2+ transport transmembrane protein MgtE YP_001848986.1 804824 R 216594 CDS YP_001848987.1 183980696 6224920 complement(806979..807794) 1 NC_010612.1 hypothetical protein 807794 6224920 MMAR_0671 Mycobacterium marinum M hypothetical protein YP_001848987.1 806979 R 216594 CDS YP_001848988.1 183980697 6224921 807936..808358 1 NC_010612.1 hypothetical protein 808358 6224921 MMAR_0672 Mycobacterium marinum M hypothetical protein YP_001848988.1 807936 D 216594 CDS YP_001848989.1 183980698 6224922 808582..809340 1 NC_010612.1 hypothetical protein 809340 6224922 MMAR_0673 Mycobacterium marinum M hypothetical protein YP_001848989.1 808582 D 216594 CDS YP_001848990.1 183980699 6224923 809355..809615 1 NC_010612.1 hypothetical protein 809615 6224923 MMAR_0674 Mycobacterium marinum M hypothetical protein YP_001848990.1 809355 D 216594 CDS YP_001848991.1 183980700 6224924 809619..809756 1 NC_010612.1 hypothetical protein 809756 6224924 MMAR_0675 Mycobacterium marinum M hypothetical protein YP_001848991.1 809619 D 216594 CDS YP_001848992.1 183980701 6224925 809757..810731 1 NC_010612.1 involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids; glycolipid sulfotransferase 810731 6224925 MMAR_0676 Mycobacterium marinum M glycolipid sulfotransferase YP_001848992.1 809757 D 216594 CDS YP_001848993.1 183980702 6224926 complement(810761..811684) 1 NC_010612.1 possibly involved in export of metal ions across the membrane; efflux membrane protein 811684 6224926 MMAR_0677 Mycobacterium marinum M efflux membrane protein YP_001848993.1 810761 R 216594 CDS YP_001848994.1 183980703 6224927 complement(811729..812499) 1 NC_010612.1 hypothetical protein 812499 6224927 MMAR_0678 Mycobacterium marinum M hypothetical protein YP_001848994.1 811729 R 216594 CDS YP_001848995.1 183980704 6224928 complement(812519..813196) 1 NC_010612.1 hypothetical protein 813196 6224928 MMAR_0679 Mycobacterium marinum M hypothetical protein YP_001848995.1 812519 R 216594 CDS YP_001848996.1 183980705 6224929 813287..814585 1 NC_010612.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 814585 purA 6224929 purA Mycobacterium marinum M adenylosuccinate synthetase YP_001848996.1 813287 D 216594 CDS YP_001848997.1 183980706 6224930 814582..815241 1 NC_010612.1 hypothetical protein 815241 6224930 MMAR_0681 Mycobacterium marinum M hypothetical protein YP_001848997.1 814582 D 216594 CDS YP_001848998.1 183980707 6224933 complement(815627..816274) 1 NC_010612.1 putative regulatory protein 816274 6224933 MMAR_0684 Mycobacterium marinum M putative regulatory protein YP_001848998.1 815627 R 216594 CDS YP_001848999.1 183980708 6224934 complement(816586..817920) 1 NC_010612.1 PPE family protein 817920 6224934 MMAR_0685 Mycobacterium marinum M PPE family protein YP_001848999.1 816586 R 216594 CDS YP_001849000.1 183980709 6224935 818393..819730 1 NC_010612.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 819730 purT 6224935 purT Mycobacterium marinum M phosphoribosylglycinamide formyltransferase 2 YP_001849000.1 818393 D 216594 CDS YP_001849001.1 183980710 6224936 819727..820155 1 NC_010612.1 contains conserved rhodanese domain superfamily, subgroup 1. this domain includes the putative rhodanese- related sulfurtransferases of several uncharacterized proteins; hypothetical protein 820155 6224936 MMAR_0687 Mycobacterium marinum M hypothetical protein YP_001849001.1 819727 D 216594 CDS YP_001849002.1 183980711 6224937 820243..821481 1 NC_010612.1 involved in methionine biosynthesis. converts O- succinylhomoserine into homocysteine; O-succinylhomoserine sulfhydrylase 821481 metZ 6224937 metZ Mycobacterium marinum M O-succinylhomoserine sulfhydrylase YP_001849002.1 820243 D 216594 CDS YP_001849003.1 183980712 6224938 complement(821536..822951) 1 NC_010612.1 transfer of electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation; NADH dehydrogenase Ndh 822951 ndh_1 6224938 ndh_1 Mycobacterium marinum M NADH dehydrogenase Ndh YP_001849003.1 821536 R 216594 CDS YP_001849004.1 183980713 6224939 823595..824785 1 NC_010612.1 function unknown, but seems involved in efflux system (probably sugar or drug transport); putative transport protein 824785 6224939 MMAR_0690 Mycobacterium marinum M putative transport protein YP_001849004.1 823595 D 216594 CDS YP_001849005.1 183980714 6224940 complement(824795..826768) 1 NC_010612.1 function unknown but high domain identity with choline/carnitine o-acyltransferases; hypothetical protein 826768 6224940 MMAR_0691 Mycobacterium marinum M hypothetical protein YP_001849005.1 824795 R 216594 CDS YP_001849006.1 183980715 6224941 complement(826765..827898) 1 NC_010612.1 gamma-butyrobetaine hydroxylase is a 2-oxoglutarate- dependent dioxygenase that catalyzes the hydroxylation of gamma-butyrobetaine to carnitine, the last step in the biosynthesis of carnitine from lysine. reaction catalysed: 4-trimethylammoniobutanoate + 2-oxoglutarate + O(2) <=> 3- hydroxy-4-trimethylammoniobutanoate + succinate + CO(2); gamma-butyrobetaine hydroxylase, TauD 827898 tauD_1 6224941 tauD_1 Mycobacterium marinum M gamma-butyrobetaine hydroxylase, TauD YP_001849006.1 826765 R 216594 CDS YP_001849007.1 183980716 6224942 complement(827898..828386) 1 NC_010612.1 decarboxylation of aspartate. this is the major route of beta-alanine production in bacteria, and is catalysed by the enzyme aspartate decarboxylase which requires a pyruvoyl group for its activity; aspartate decarboxylase, PanD 828386 panD_1 6224942 panD_1 Mycobacterium marinum M aspartate decarboxylase, PanD YP_001849007.1 827898 R 216594 CDS YP_001849008.1 183980717 6224943 complement(828383..829897) 1 NC_010612.1 function unknown, contains two UbiE domains: methylase involved in ubiquinone/menaquinone biosynthesis; hypothetical protein 829897 6224943 MMAR_0694 Mycobacterium marinum M hypothetical protein YP_001849008.1 828383 R 216594 CDS YP_001849009.1 183980718 6224944 complement(830263..830913) 1 NC_010612.1 hypothetical protein 830913 6224944 MMAR_0695 Mycobacterium marinum M hypothetical protein YP_001849009.1 830263 R 216594 CDS YP_001849010.1 183980719 6224945 complement(830917..832158) 1 NC_010612.1 lipoprotein LpqK 832158 lpqK 6224945 lpqK Mycobacterium marinum M lipoprotein LpqK YP_001849010.1 830917 R 216594 CDS YP_001849011.1 183980720 6224946 complement(832208..833356) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 833356 6224946 MMAR_0697 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001849011.1 832208 R 216594 CDS YP_001849012.1 183980721 6224947 complement(833368..834555) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE7 834555 fadE7 6224947 fadE7 Mycobacterium marinum M acyl-CoA dehydrogenase FadE7 YP_001849012.1 833368 R 216594 CDS YP_001849013.1 183980722 6224948 834591..834971 1 NC_010612.1 hypothetical protein 834971 6224948 MMAR_0699 Mycobacterium marinum M hypothetical protein YP_001849013.1 834591 D 216594 CDS YP_001849014.1 183980723 6224949 835145..835651 1 NC_010612.1 function unknown but has domain identity with acetyltransferases; hypothetical protein 835651 6224949 MMAR_0700 Mycobacterium marinum M hypothetical protein YP_001849014.1 835145 D 216594 CDS YP_001849015.1 183980724 6224950 835648..836754 1 NC_010612.1 function unknown; probably involved in cellular metabolism; oxidoreductase 836754 6224950 MMAR_0701 Mycobacterium marinum M oxidoreductase YP_001849015.1 835648 D 216594 CDS YP_001849016.1 183980725 6224951 836751..837869 1 NC_010612.1 monooxygenase-like hypothetical protein 837869 6224951 MMAR_0702 Mycobacterium marinum M monooxygenase-like hypothetical protein YP_001849016.1 836751 D 216594 CDS YP_001849017.1 183980726 6224952 837866..839197 1 NC_010612.1 function unknown: involved in energy production and conversion; FMNH2-utilizing oxygenase 839197 6224952 MMAR_0703 Mycobacterium marinum M FMNH2-utilizing oxygenase YP_001849017.1 837866 D 216594 CDS YP_001849018.1 183980727 6224953 complement(839111..841987) 1 NC_010612.1 function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL 841987 mmpL1 6224953 mmpL1 Mycobacterium marinum M transmembrane transport protein MmpL YP_001849018.1 839111 R 216594 CDS YP_001849019.1 183980728 6224954 complement(841984..842412) 1 NC_010612.1 membrane protein MmpS1 842412 mmpS1_1 6224954 mmpS1_1 Mycobacterium marinum M membrane protein MmpS1 YP_001849019.1 841984 R 216594 CDS YP_001849020.1 183980729 6224955 842939..844708 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 844708 fadD30 6224955 fadD30 Mycobacterium marinum M acyl-CoA synthetase YP_001849020.1 842939 D 216594 CDS YP_001849021.1 183980730 6224956 844705..851949 1 NC_010612.1 production of unknown apolar lipid. contains two modules. KS-ATa-ACP, KS-ATa-ACP and terminal te domain; polyketide synthase 851949 pks6 6224956 pks6 Mycobacterium marinum M polyketide synthase YP_001849021.1 844705 D 216594 CDS YP_001849022.1 183980731 6224957 complement(851973..852725) 1 NC_010612.1 beta lactamase-like protein 852725 6224957 MMAR_0708 Mycobacterium marinum M beta lactamase-like protein YP_001849022.1 851973 R 216594 CDS YP_001849023.1 183980732 6224958 852969..853979 1 NC_010612.1 catalyzes oxidation of glucose-6-phosphate to 6- phosphogluconolactone using coenzyme F420 (an *-hydroxy-5- deazaflavin derivative) as the electron acceptor; F420-dependent glucose-6-phosphate dehydrogenase Fgd1 853979 fgd1 6224958 fgd1 Mycobacterium marinum M F420-dependent glucose-6-phosphate dehydrogenase Fgd1 YP_001849023.1 852969 D 216594 CDS YP_001849024.1 183980733 6224959 853987..856071 1 NC_010612.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 856071 pta 6224959 pta Mycobacterium marinum M phosphate acetyltransferase YP_001849024.1 853987 D 216594 CDS YP_001849025.1 183980734 6224960 856061..857227 1 NC_010612.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 857227 ackA 6224960 ackA Mycobacterium marinum M acetate kinase YP_001849025.1 856061 D 216594 CDS YP_001849026.1 183980735 6224961 857406..858266 1 NC_010612.1 hypothetical protein 858266 6224961 MMAR_0712 Mycobacterium marinum M hypothetical protein YP_001849026.1 857406 D 216594 CDS YP_001849027.1 183980736 6224962 complement(858391..860694) 1 NC_010612.1 involved in signal transduction (via phosphorylation). thought to regulate amino-acid uptake and stationary-phase metabolism. phosphorylates the peptide substrate myelin basic protein (MBP) at serine residues [catalytic activity: ATP + a protein = ADP + a P; serine/threonine-protein kinase PknG 860694 pknG 6224962 pknG Mycobacterium marinum M serine/threonine-protein kinase PknG YP_001849027.1 858391 R 216594 CDS YP_001849028.1 183980737 6224963 complement(860694..861680) 1 NC_010612.1 involved in active transport of glutamine across the membrane (import). interacts with the glutamine- transport system; glutamine-binding lipoprotein GlnH 861680 glnH 6224963 glnH Mycobacterium marinum M glutamine-binding lipoprotein GlnH YP_001849028.1 860694 R 216594 CDS YP_001849029.1 183980738 6224964 complement(861680..862999) 1 NC_010612.1 hypothetical protein 862999 6224964 MMAR_0715 Mycobacterium marinum M hypothetical protein YP_001849029.1 861680 R 216594 CDS YP_001849030.1 183980739 6224965 863151..863774 1 NC_010612.1 possibly involved in the go system responsible for removing an oxidatively damaged form of guanine (7,8- dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8- OXO-dGTP is inserted opposite da and dc residues of template DNA with almost equal efficiency thus leading to a.T to G.C transversions. mutt specifically degrades 8-OXO- dGTP to the monophosphate [catalytic activity: 8-OXO-dGTP + H2O = 8-OXO-DGMP + pyrophosphate]; mutator protein MutT3 863774 mutT3 6224965 mutT3 Mycobacterium marinum M mutator protein MutT3 YP_001849030.1 863151 D 216594 CDS YP_001849031.1 183980740 6224966 complement(863746..864408) 1 NC_010612.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 864408 thiE 6224966 thiE Mycobacterium marinum M thiamine-phosphate pyrophosphorylase YP_001849031.1 863746 R 216594 CDS YP_001849032.1 183980741 6224967 864570..865589 1 NC_010612.1 involved in thiamine biosynthesis; thiamine biosynthesis oxidoreductase ThiO 865589 thiO 6224967 thiO Mycobacterium marinum M thiamine biosynthesis oxidoreductase ThiO YP_001849032.1 864570 D 216594 CDS YP_001849033.1 183980742 6224968 865586..865783 1 NC_010612.1 part of the thiamine biosynthesis operon. ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer. It is coded in the THICEFSGH operon in E. coli; thiamine biosynthesis protein ThiS 865783 thiS 6224968 thiS Mycobacterium marinum M thiamine biosynthesis protein ThiS YP_001849033.1 865586 D 216594 CDS YP_001849034.1 183980743 6224969 865776..866570 1 NC_010612.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 866570 thiG 6224969 thiG Mycobacterium marinum M thiazole synthase YP_001849034.1 865776 D 216594 CDS YP_001849035.1 183980744 6224970 866567..867370 1 NC_010612.1 function unknown but domain identity with streptomyces scabies esterase protein; hydrolase 867370 6224970 MMAR_0721 Mycobacterium marinum M hydrolase YP_001849035.1 866567 D 216594 CDS YP_001849036.1 183980745 6224971 complement(867373..867897) 1 NC_010612.1 hypothetical protein 867897 6224971 MMAR_0722 Mycobacterium marinum M hypothetical protein YP_001849036.1 867373 R 216594 CDS YP_001849037.1 183980746 6224972 868233..868352 1 NC_010612.1 hypothetical protein 868352 6224972 MMAR_0723 Mycobacterium marinum M hypothetical protein YP_001849037.1 868233 D 216594 CDS YP_001849038.1 183980747 6224973 868396..868728 1 NC_010612.1 hypothetical protein 868728 6224973 MMAR_0724 Mycobacterium marinum M hypothetical protein YP_001849038.1 868396 D 216594 CDS YP_001849039.1 183980748 6224974 868743..869168 1 NC_010612.1 hypothetical protein 869168 6224974 MMAR_0725 Mycobacterium marinum M hypothetical protein YP_001849039.1 868743 D 216594 CDS YP_001849040.1 183980749 6224975 869301..870812 1 NC_010612.1 function unknown, hydrolyzes peptides and/or proteins; lipoprotein aminopeptidase LpqL 870812 lpqL 6224975 lpqL Mycobacterium marinum M lipoprotein aminopeptidase LpqL YP_001849040.1 869301 D 216594 CDS YP_001849041.1 183980750 6224976 870809..872281 1 NC_010612.1 function unknown; hydrolyzes peptides and/or proteins; lipoprotein aminopeptidase LpqL 872281 lpqL_1 6224976 lpqL_1 Mycobacterium marinum M lipoprotein aminopeptidase LpqL YP_001849041.1 870809 D 216594 CDS YP_001849042.1 183980751 6224977 872394..873887 1 NC_010612.1 function unknown, possibly hydrolyzes peptides and/or proteins; lipoprotein peptidase LpqM 873887 lpqM 6224977 lpqM Mycobacterium marinum M lipoprotein peptidase LpqM YP_001849042.1 872394 D 216594 CDS YP_001849043.1 183980752 6224978 complement(873918..877154) 1 NC_010612.1 function unknown, but may be involved in efflux system (probably sugar or drug transport); transmembrane transport protein 877154 6224978 MMAR_0729 Mycobacterium marinum M transmembrane transport protein YP_001849043.1 873918 R 216594 CDS YP_001849044.1 183980753 6224979 877627..879156 1 NC_010612.1 function unknown but contains a N-term CheY-like response regulator receiver domain and C-term adenylyl/guanylyl cyclase catalytic domain; adenylylate/guanylate cyclase 879156 6224979 MMAR_0730 Mycobacterium marinum M adenylylate/guanylate cyclase YP_001849044.1 877627 D 216594 CDS YP_001849045.1 183980754 6224980 complement(879149..879514) 1 NC_010612.1 hypothetical protein 879514 6224980 MMAR_0731 Mycobacterium marinum M hypothetical protein YP_001849045.1 879149 R 216594 CDS YP_001849046.1 183980755 6224981 complement(879511..879735) 1 NC_010612.1 hypothetical protein 879735 6224981 MMAR_0732 Mycobacterium marinum M hypothetical protein YP_001849046.1 879511 R 216594 CDS YP_001849047.1 183980756 6224982 879836..881179 1 NC_010612.1 two TetR DNA-binding domains detected; putative regulatory protein 881179 6224982 MMAR_5559 Mycobacterium marinum M putative regulatory protein YP_001849047.1 879836 D 216594 CDS YP_001849048.1 183980757 6224983 complement(881088..881723) 1 NC_010612.1 hypothetical protein 881723 6224983 MMAR_0733 Mycobacterium marinum M hypothetical protein YP_001849048.1 881088 R 216594 CDS YP_001849049.1 183980758 6224984 complement(881720..882547) 1 NC_010612.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 882547 thiD 6224984 thiD Mycobacterium marinum M phosphomethylpyrimidine kinase YP_001849049.1 881720 R 216594 CDS YP_001849050.1 183980759 6224985 complement(882544..884184) 1 NC_010612.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 884184 thiC 6224985 thiC Mycobacterium marinum M thiamine biosynthesis protein ThiC YP_001849050.1 882544 R 216594 CDS YP_001849051.1 183980760 6224986 884334..885104 1 NC_010612.1 function unknown but may be involved in signal transduction pathway as it contains a PAS-like central senor domain and an Antar domain; putative regulatory protein 885104 6224986 MMAR_0736 Mycobacterium marinum M putative regulatory protein YP_001849051.1 884334 D 216594 CDS YP_001849052.1 183980761 6224987 885208..885630 1 NC_010612.1 function unknown but domain identity shared with the anti-sigma factor antagonist superfamily spoiiaa; anti sigma factor antagonist 885630 6224987 MMAR_0737 Mycobacterium marinum M anti sigma factor antagonist YP_001849052.1 885208 D 216594 CDS YP_001849053.1 183980762 6224988 885627..889490 1 NC_010612.1 two-component sensor and regulator 889490 6224988 MMAR_0738 Mycobacterium marinum M two-component sensor and regulator YP_001849053.1 885627 D 216594 CDS YP_001849054.1 183980763 6224989 complement(889524..889802) 1 NC_010612.1 hypothetical protein 889802 6224989 MMAR_0739 Mycobacterium marinum M hypothetical protein YP_001849054.1 889524 R 216594 CDS YP_001849055.1 183980764 6224990 complement(889849..894462) 1 NC_010612.1 metal cation-transporting ATPase; may catalyze the transport of undeterminaed metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminted metal cation (in) = ADP + phosphate + undeterminaed metal cation (out)]; metal cation transporting p-type ATPase CtpH 894462 ctpH 6224990 ctpH Mycobacterium marinum M metal cation transporting p-type ATPase CtpH YP_001849055.1 889849 R 216594 CDS YP_001849056.1 183980765 6224991 complement(894482..894928) 1 NC_010612.1 transmembrane protein 894928 6224991 MMAR_0741 Mycobacterium marinum M transmembrane protein YP_001849056.1 894482 R 216594 CDS YP_001849057.1 183980766 6224992 complement(895072..895902) 1 NC_010612.1 involved in base excision repair. apurinic- apyrimidinic endonuclease. supposed to remove the damaged DNA at cytosines and guanines by cleaving at the 3' side of the ap site by a beta-elimination reaction. possibly exhibites 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'- repair diesterase and ribonuclease H activities [catalytic activity: degradation of double-stranded DNA. it acts progressively in a 3'- to 5'-direction, releasing 5'- phosphomononucleotides]; exodeoxyribonuclease III protein XthA 895902 xthA 6224992 xthA Mycobacterium marinum M exodeoxyribonuclease III protein XthA YP_001849057.1 895072 R 216594 CDS YP_001849058.1 183980767 6224993 complement(895905..896801) 1 NC_010612.1 hypothetical protein 896801 6224993 MMAR_0743 Mycobacterium marinum M hypothetical protein YP_001849058.1 895905 R 216594 CDS YP_001849059.1 183980768 6224994 complement(896801..897394) 1 NC_010612.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 897394 def 6224994 def Mycobacterium marinum M peptide deformylase YP_001849059.1 896801 R 216594 CDS YP_001849060.1 183980769 6224995 897644..897952 1 NC_010612.1 hypothetical protein 897952 6224995 MMAR_0745 Mycobacterium marinum M hypothetical protein YP_001849060.1 897644 D 216594 CDS YP_001849061.1 183980770 6224996 898017..898499 1 NC_010612.1 tuberculin-like protein 898499 6224996 MMAR_0746 Mycobacterium marinum M tuberculin-like protein YP_001849061.1 898017 D 216594 CDS YP_001849062.1 183980771 6224997 898572..899288 1 NC_010612.1 destroys radicals which are normally produced within the cells and are toxic to biological systems [catalytic activity: 2 superoxide + 2 H+ = O2 + H2O2]; periplasmic superoxide dismutase [Cu-Zn] SodC 899288 sodC 6224997 sodC Mycobacterium marinum M periplasmic superoxide dismutase [Cu-Zn] SodC YP_001849062.1 898572 D 216594 CDS YP_001849063.1 183980772 6224998 899269..900420 1 NC_010612.1 ATP-dependent carboxylate-amine ligase; carboxylate-amine ligase 900420 6224998 MMAR_0748 Mycobacterium marinum M carboxylate-amine ligase YP_001849063.1 899269 D 216594 CDS YP_001849064.1 183980773 6224999 complement(900525..901196) 1 NC_010612.1 involved in transcriptional mechanism; GntR family transcriptional regulator 901196 6224999 MMAR_0749 Mycobacterium marinum M GntR family transcriptional regulator YP_001849064.1 900525 R 216594 CDS YP_001849065.1 183980774 6225000 901281..902588 1 NC_010612.1 function unknown, possibly involved in inorganic ion transport; MFS transporter 902588 6225000 MMAR_0750 Mycobacterium marinum M MFS transporter YP_001849065.1 901281 D 216594 CDS YP_001849066.1 183980775 6225001 902726..903382 1 NC_010612.1 hypothetical protein 903382 6225001 MMAR_0751 Mycobacterium marinum M hypothetical protein YP_001849066.1 902726 D 216594 CDS YP_001849067.1 183980776 6225002 complement(903389..905563) 1 NC_010612.1 ATPase; possibly catalyzes the transport of undeterminated substrate with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated substrate(in) = ADP + phosphate + undeterminated substrate(out)]; ATPase 905563 6225002 MMAR_0752 Mycobacterium marinum M ATPase YP_001849067.1 903389 R 216594 CDS YP_001849068.1 183980777 6225003 complement(905560..906378) 1 NC_010612.1 involved in phospholipid biosynthesis. generates phosphatidylserine [catalytic activity: CDP-diacylglycerol + L-serine = CMP + O-SN-phosphatidyl-L-serine]; CDP-diacylglycerol--serine O-phosphatidyltransferase 906378 pssA 6225003 pssA Mycobacterium marinum M CDP-diacylglycerol--serine O-phosphatidyltransferase YP_001849068.1 905560 R 216594 CDS YP_001849069.1 183980778 6225004 complement(906432..907154) 1 NC_010612.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 907154 psd 6225004 psd Mycobacterium marinum M phosphatidylserine decarboxylase YP_001849069.1 906432 R 216594 CDS YP_001849070.1 183980779 6225005 complement(907240..910416) 1 NC_010612.1 PE-PGRS family protein 910416 6225005 MMAR_0755 Mycobacterium marinum M PE-PGRS family protein YP_001849070.1 907240 R 216594 CDS YP_001849071.1 183980780 6225006 complement(910730..911935) 1 NC_010612.1 involved in molybdenum cofactor biosynthesis: involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes (by similarity); molybdopterin biosynthesis protein MoeA2 911935 moeA2 6225006 moeA2 Mycobacterium marinum M molybdopterin biosynthesis protein MoeA2 YP_001849071.1 910730 R 216594 CDS YP_001849072.1 183980781 6225007 complement(911954..912892) 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short chain dehydrogenase 912892 6225007 MMAR_0757 Mycobacterium marinum M short chain dehydrogenase YP_001849072.1 911954 R 216594 CDS YP_001849073.1 183980782 6225008 complement(912939..913442) 1 NC_010612.1 hypothetical protein 913442 6225008 MMAR_0758 Mycobacterium marinum M hypothetical protein YP_001849073.1 912939 R 216594 CDS YP_001849074.1 183980783 6225009 913752..915377 1 NC_010612.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 915377 groEL 6225009 groEL Mycobacterium marinum M chaperonin GroEL YP_001849074.1 913752 D 216594 CDS YP_001849075.1 183980784 6225010 complement(915462..915851) 1 NC_010612.1 hypothetical protein 915851 6225010 MMAR_0760 Mycobacterium marinum M hypothetical protein YP_001849075.1 915462 R 216594 CDS YP_001849076.1 183980785 6225011 complement(915918..917384) 1 NC_010612.1 PPE family protein 917384 6225011 MMAR_0761 Mycobacterium marinum M PPE family protein YP_001849076.1 915918 R 216594 CDS YP_001849077.1 183980786 6225012 complement(917480..919228) 1 NC_010612.1 hydrolizes a specific D-amino acid; D-amino acid aminohydrolase 919228 6225012 MMAR_0762 Mycobacterium marinum M D-amino acid aminohydrolase YP_001849077.1 917480 R 216594 CDS YP_001849078.1 183980787 6225013 919294..919809 1 NC_010612.1 hypothetical protein 919809 6225013 MMAR_0763 Mycobacterium marinum M hypothetical protein YP_001849078.1 919294 D 216594 CDS YP_001849079.1 183980788 6225014 919819..920667 1 NC_010612.1 hypothetical protein 920667 6225014 MMAR_0764 Mycobacterium marinum M hypothetical protein YP_001849079.1 919819 D 216594 CDS YP_001849080.1 183980789 6225015 complement(920679..921377) 1 NC_010612.1 hypothetical protein 921377 6225015 MMAR_0765 Mycobacterium marinum M hypothetical protein YP_001849080.1 920679 R 216594 CDS YP_001849081.1 183980790 6225016 complement(921374..921937) 1 NC_010612.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins; RNA polymerase sigma factor SigK 921937 sigK 6225016 sigK Mycobacterium marinum M RNA polymerase sigma factor SigK YP_001849081.1 921374 R 216594 CDS YP_001849082.1 183980791 6225017 complement(921983..922777) 1 NC_010612.1 transmembrane protein 922777 6225017 MMAR_0767 Mycobacterium marinum M transmembrane protein YP_001849082.1 921983 R 216594 CDS YP_001849083.1 183980792 6225018 complement(922774..924060) 1 NC_010612.1 transfers a methylene group from S-adenosyl-L- methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge [catalytic activity: S-adenosyl-L- methionine + phospholipid olefinic fatty acid = S-adenosyl- L-homocysteine + phospholipid cyclopropane fatty acid]; cyclopropane-fatty-acyl-phospholipid synthase 924060 ufaA1 6225018 ufaA1 Mycobacterium marinum M cyclopropane-fatty-acyl-phospholipid synthase YP_001849083.1 922774 R 216594 CDS YP_001849084.1 183980793 6225019 complement(924057..924773) 1 NC_010612.1 hypothetical protein 924773 6225019 MMAR_0769 Mycobacterium marinum M hypothetical protein YP_001849084.1 924057 R 216594 CDS YP_001849085.1 183980794 6225020 complement(924767..926083) 1 NC_010612.1 oxidoreductase 926083 6225020 MMAR_0770 Mycobacterium marinum M oxidoreductase YP_001849085.1 924767 R 216594 CDS YP_001849086.1 183980795 6225021 complement(926142..929039) 1 NC_010612.1 thought to be involved in fatty acid transport; transmembrane transport protein MmpL 929039 mmpL5_2 6225021 mmpL5_2 Mycobacterium marinum M transmembrane transport protein MmpL YP_001849086.1 926142 R 216594 CDS YP_001849087.1 183980796 6225022 complement(929036..929455) 1 NC_010612.1 membrane protein MmpS4_2 929455 mmpS4_2 6225022 mmpS4_2 Mycobacterium marinum M membrane protein MmpS4_2 YP_001849087.1 929036 R 216594 CDS YP_001849088.1 183980797 6225023 929771..930508 1 NC_010612.1 putative regulatory protein 930508 6225023 MMAR_0773 Mycobacterium marinum M putative regulatory protein YP_001849088.1 929771 D 216594 CDS YP_001849089.1 183980798 6225024 930767..931213 1 NC_010612.1 hypothetical protein 931213 6225024 MMAR_0774 Mycobacterium marinum M hypothetical protein YP_001849089.1 930767 D 216594 CDS YP_001849090.1 183980799 6225025 931210..934236 1 NC_010612.1 the function of MmpL proteins is not known, although it has been suggested that they may be involved in lipid transport; MmpL family transport protein 934236 6225025 MMAR_0775 Mycobacterium marinum M MmpL family transport protein YP_001849090.1 931210 D 216594 CDS YP_001849091.1 183980800 6225026 complement(934268..934615) 1 NC_010612.1 hypothetical protein 934615 6225026 MMAR_0776 Mycobacterium marinum M hypothetical protein YP_001849091.1 934268 R 216594 CDS YP_001849092.1 183980801 6225027 complement(934891..935340) 1 NC_010612.1 hypothetical protein 935340 6225027 MMAR_0777 Mycobacterium marinum M hypothetical protein YP_001849092.1 934891 R 216594 CDS YP_001849093.1 183980802 6225028 complement(935407..936321) 1 NC_010612.1 catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 936321 echA2 6225028 echA2 Mycobacterium marinum M enoyl-CoA hydratase YP_001849093.1 935407 R 216594 CDS YP_001849094.1 183980803 6225029 complement(936413..938509) 1 NC_010612.1 function unknown; hydrolyzes peptides and/or proteins; peptidase 938509 6225029 MMAR_0779 Mycobacterium marinum M peptidase YP_001849094.1 936413 R 216594 CDS YP_001849095.1 183980804 6225030 938575..940098 1 NC_010612.1 interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; aldehyde dehydrogenase, PutA 940098 putA_1 6225030 putA_1 Mycobacterium marinum M aldehyde dehydrogenase, PutA YP_001849095.1 938575 D 216594 CDS YP_001849096.1 183980805 6225031 940098..940598 1 NC_010612.1 hypothetical protein 940598 6225031 MMAR_0781 Mycobacterium marinum M hypothetical protein YP_001849096.1 940098 D 216594 CDS YP_001849097.1 183980806 6225032 940619..940897 1 NC_010612.1 hypothetical protein 940897 6225032 MMAR_0782 Mycobacterium marinum M hypothetical protein YP_001849097.1 940619 D 216594 CDS YP_001849098.1 183980807 6225033 940890..941498 1 NC_010612.1 transmembrane protein 941498 6225033 MMAR_0783 Mycobacterium marinum M transmembrane protein YP_001849098.1 940890 D 216594 CDS YP_001849099.1 183980808 6225034 complement(941556..942944) 1 NC_010612.1 could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase 942944 bioF2_4 6225034 bioF2_4 Mycobacterium marinum M 8-amino-7-oxononanoate synthase YP_001849099.1 941556 R 216594 CDS YP_001849100.1 183980809 6225035 943178..944581 1 NC_010612.1 E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase 944581 lpd 6225035 lpd Mycobacterium marinum M dihydrolipoamide dehydrogenase YP_001849100.1 943178 D 216594 CDS YP_001849101.1 183980810 6225036 944584..944859 1 NC_010612.1 hypothetical protein 944859 6225036 MMAR_0786 Mycobacterium marinum M hypothetical protein YP_001849101.1 944584 D 216594 CDS YP_001849102.1 183980811 6225037 complement(944865..945059) 1 NC_010612.1 hypothetical protein 945059 6225037 MMAR_5564 Mycobacterium marinum M hypothetical protein YP_001849102.1 944865 R 216594 CDS YP_001849103.1 183980812 6225038 complement(945132..946370) 1 NC_010612.1 PPE family protein 946370 6225038 MMAR_0787 Mycobacterium marinum M PPE family protein YP_001849103.1 945132 R 216594 CDS YP_001849104.1 183980813 6225039 complement(946601..947167) 1 NC_010612.1 hypothetical protein 947167 6225039 MMAR_0789 Mycobacterium marinum M hypothetical protein YP_001849104.1 946601 R 216594 CDS YP_001849105.1 183980814 6225040 complement(947164..948588) 1 NC_010612.1 possibly involved in transcriptional mechanism; transcriptional regulatory protein 948588 6225040 MMAR_0790 Mycobacterium marinum M transcriptional regulatory protein YP_001849105.1 947164 R 216594 CDS YP_001849106.1 183980815 6225041 948763..949557 1 NC_010612.1 hypothetical protein 949557 6225041 MMAR_0791 Mycobacterium marinum M hypothetical protein YP_001849106.1 948763 D 216594 CDS YP_001849107.1 183980816 6225042 949865..951151 1 NC_010612.1 involved in glyoxylate bypass (at the first step), an alternative to the tricarboxylic acid cycle (in bacteria, plants, and fungi) [catalytic activity: isocitrate = succinate + glyoxylate]. involved in the persistence in the host; isocitrate lyase Icl 951151 icl 6225042 icl Mycobacterium marinum M isocitrate lyase Icl YP_001849107.1 949865 D 216594 CDS YP_001849108.1 183980817 6225043 951315..952181 1 NC_010612.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 952181 fadB2 6225043 fadB2 Mycobacterium marinum M 3-hydroxybutyryl-CoA dehydrogenase YP_001849108.1 951315 D 216594 CDS YP_001849109.1 183980818 6225044 952317..953177 1 NC_010612.1 involved in mycolic acid modification or synthesis; mycolic acid synthase UmaA 953177 umaA 6225044 umaA Mycobacterium marinum M mycolic acid synthase UmaA YP_001849109.1 952317 D 216594 CDS YP_001849110.1 183980819 6225045 complement(953410..954381) 1 NC_010612.1 transposition of ISMyma04; transposase for ISMyma04 954381 6225045 MMAR_0795 Mycobacterium marinum M transposase for ISMyma04 YP_001849110.1 953410 R 216594 CDS YP_001849111.1 183980820 6225046 complement(954500..955363) 1 NC_010612.1 involved in the mycolic acid modification or synthesis; essential for the cyclopropanation function. required for cording and mycolic acid cyclopropane ring synthesis in the cell wall; mycolic acid synthase PcaA 955363 pcaA 6225046 pcaA Mycobacterium marinum M mycolic acid synthase PcaA YP_001849111.1 954500 R 216594 CDS YP_001849112.1 183980821 6225047 complement(955521..956225) 1 NC_010612.1 possibly involved in transcriptional mechanism; TetR family transcriptional regulator 956225 6225047 MMAR_0797 Mycobacterium marinum M TetR family transcriptional regulator YP_001849112.1 955521 R 216594 CDS YP_001849113.1 183980822 6225048 956417..957700 1 NC_010612.1 transmembrane protein 957700 6225048 MMAR_0798 Mycobacterium marinum M transmembrane protein YP_001849113.1 956417 D 216594 CDS YP_001849114.1 183980823 6225049 957786..958202 1 NC_010612.1 possibly involved in transcriptional mechanism; transcriptional regulatory protein 958202 6225049 MMAR_0799 Mycobacterium marinum M transcriptional regulatory protein YP_001849114.1 957786 D 216594 CDS YP_001849115.1 183980824 6225050 958557..959162 1 NC_010612.1 required for extrapulmonary dissemination. mediates adherence to epithelial cells by binding to sulfated glycoconjugates present at the surface of these cells; binds heparin, dextran sulfate, fucoidan and chondroitin sulfate. promotes hemagglutination of erythrocytes of certain host species. induces mycobacterial aggregation; iron-regulated heparin binding hemagglutinin HbhA 959162 hbhA 6225050 hbhA Mycobacterium marinum M iron-regulated heparin binding hemagglutinin HbhA YP_001849115.1 958557 D 216594 CDS YP_001849116.1 183980825 6225051 959315..959602 1 NC_010612.1 transmembrane protein 959602 6225051 MMAR_0801 Mycobacterium marinum M transmembrane protein YP_001849116.1 959315 D 216594 CDS YP_001849117.1 183980826 6225052 959607..960089 1 NC_010612.1 hypothetical protein 960089 6225052 MMAR_0802 Mycobacterium marinum M hypothetical protein YP_001849117.1 959607 D 216594 CDS YP_001849118.1 183980827 6225053 960089..960769 1 NC_010612.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 960769 deoC 6225053 deoC Mycobacterium marinum M deoxyribose-phosphate aldolase YP_001849118.1 960089 D 216594 CDS YP_001849119.1 183980828 6225054 complement(960788..961834) 1 NC_010612.1 hypothetical protein 961834 6225054 MMAR_0804 Mycobacterium marinum M hypothetical protein YP_001849119.1 960788 R 216594 CDS YP_001849120.1 183980829 6225055 complement(961831..962673) 1 NC_010612.1 function unknown, hydrolytic enzyme probably involved in cellular metabolism; amidohydrolase 962673 6225055 MMAR_0805 Mycobacterium marinum M amidohydrolase YP_001849120.1 961831 R 216594 CDS YP_001849121.1 183980830 6225056 complement(962704..969012) 1 NC_010612.1 PE-PGRS family protein 969012 6225056 MMAR_0806 Mycobacterium marinum M PE-PGRS family protein YP_001849121.1 962704 R 216594 CDS YP_001849122.1 183980831 6225057 complement(969429..969953) 1 NC_010612.1 hypothetical protein 969953 6225057 MMAR_0807 Mycobacterium marinum M hypothetical protein YP_001849122.1 969429 R 216594 CDS YP_001849123.1 183980832 6225058 969980..971080 1 NC_010612.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 971080 murB 6225058 murB Mycobacterium marinum M UDP-N-acetylenolpyruvoylglucosamine reductase YP_001849123.1 969980 D 216594 CDS YP_001849124.1 183980833 6225059 971116..972504 1 NC_010612.1 lipoprotein LprQ 972504 lprQ 6225059 lprQ Mycobacterium marinum M lipoprotein LprQ YP_001849124.1 971116 D 216594 CDS YP_001849125.1 183980834 6225060 complement(972488..973240) 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short-chain type oxidoreductase 973240 6225060 MMAR_0810 Mycobacterium marinum M short-chain type oxidoreductase YP_001849125.1 972488 R 216594 CDS YP_001849126.1 183980835 6225061 973483..974718 1 NC_010612.1 possibly involved in transcriptional mechanism; transcriptional regulatory protein 974718 6225061 MMAR_0811 Mycobacterium marinum M transcriptional regulatory protein YP_001849126.1 973483 D 216594 CDS YP_001849127.1 183980836 6225062 974730..976130 1 NC_010612.1 thought to be involved in polyprenolmannose synthesis; mannosyltransferase 976130 6225062 MMAR_0812 Mycobacterium marinum M mannosyltransferase YP_001849127.1 974730 D 216594 CDS YP_001849128.1 183980837 6225063 976127..976678 1 NC_010612.1 hypothetical protein 976678 6225063 MMAR_0813 Mycobacterium marinum M hypothetical protein YP_001849128.1 976127 D 216594 CDS YP_001849129.1 183980838 6225064 976692..977447 1 NC_010612.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 977447 gpmA 6225064 gpmA Mycobacterium marinum M phosphoglyceromutase YP_001849129.1 976692 D 216594 CDS YP_001849130.1 183980839 6225065 977583..978809 1 NC_010612.1 sensor part of a two-component regulatory system. probably forms part of a two-component regulatory system SenX3/RegX3; phosphorylates RegX3; two-component sensor histidine kinase SenX3 978809 senX3 6225065 senX3 Mycobacterium marinum M two-component sensor histidine kinase SenX3 YP_001849130.1 977583 D 216594 CDS YP_001849131.1 183980840 6225066 978965..979648 1 NC_010612.1 transcriptional regulatory protein part of the two-component regulatory system RegX3/SenX3; two-component sensory transduction protein RegX3 979648 regX3 6225066 regX3 Mycobacterium marinum M two-component sensory transduction protein RegX3 YP_001849131.1 978965 D 216594 CDS YP_001849132.1 183980841 6225067 complement(979611..981524) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase GMC-type 981524 6225067 MMAR_0817 Mycobacterium marinum M oxidoreductase GMC-type YP_001849132.1 979611 R 216594 CDS YP_001849133.1 183980842 6225068 complement(981521..981862) 1 NC_010612.1 hypothetical protein 981862 6225068 MMAR_0818 Mycobacterium marinum M hypothetical protein YP_001849133.1 981521 R 216594 CDS YP_001849134.1 183980843 6225069 complement(981895..982866) 1 NC_010612.1 hypothetical protein 982866 6225069 MMAR_0819 Mycobacterium marinum M hypothetical protein YP_001849134.1 981895 R 216594 CDS YP_001849135.1 183980844 6225070 982954..983691 1 NC_010612.1 involved in transcriptional mechanism; GntR family transcriptional regulator 983691 6225070 MMAR_0820 Mycobacterium marinum M GntR family transcriptional regulator YP_001849135.1 982954 D 216594 CDS YP_001849136.1 183980845 6225071 complement(983704..984498) 1 NC_010612.1 hypothetical protein 984498 6225071 MMAR_0821 Mycobacterium marinum M hypothetical protein YP_001849136.1 983704 R 216594 CDS YP_001849137.1 183980846 6225072 984638..985672 1 NC_010612.1 hypothetical protein 985672 6225072 MMAR_0822 Mycobacterium marinum M hypothetical protein YP_001849137.1 984638 D 216594 CDS YP_001849138.1 183980847 6225073 985669..986733 1 NC_010612.1 transmembrane protein 986733 6225073 MMAR_0823 Mycobacterium marinum M transmembrane protein YP_001849138.1 985669 D 216594 CDS YP_001849139.1 183980848 6225074 986750..987592 1 NC_010612.1 hypothetical protein 987592 6225074 MMAR_0824 Mycobacterium marinum M hypothetical protein YP_001849139.1 986750 D 216594 CDS YP_001849140.1 183980849 6225075 987594..988439 1 NC_010612.1 hypothetical protein 988439 6225075 MMAR_0825 Mycobacterium marinum M hypothetical protein YP_001849140.1 987594 D 216594 CDS YP_001849141.1 183980850 6225076 988464..989348 1 NC_010612.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 989348 proC 6225076 proC Mycobacterium marinum M pyrroline-5-carboxylate reductase YP_001849141.1 988464 D 216594 CDS YP_001849142.1 183980851 6225077 989490..989747 1 NC_010612.1 hypothetical protein 989747 6225077 MMAR_0827 Mycobacterium marinum M hypothetical protein YP_001849142.1 989490 D 216594 CDS YP_001849143.1 183980852 6225078 989886..989987 1 NC_010612.1 hypothetical protein 989987 6225078 MMAR_0828 Mycobacterium marinum M hypothetical protein YP_001849143.1 989886 D 216594 CDS YP_001849144.1 183980853 6225079 990066..991199 1 NC_010612.1 involved in galactose metabolism [catalytic activity: UDP-glucose = UDP-galactose]; UDP-glucose 4-epimerase GalE2 991199 galE2 6225079 galE2 Mycobacterium marinum M UDP-glucose 4-epimerase GalE2 YP_001849144.1 990066 D 216594 CDS YP_001849145.1 183980854 6225080 991205..992272 1 NC_010612.1 hypothetical protein 992272 6225080 MMAR_0830 Mycobacterium marinum M hypothetical protein YP_001849145.1 991205 D 216594 CDS YP_001849146.1 183980855 6225081 complement(992326..993237) 1 NC_010612.1 essential for the cyclopropanation function. transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge. mycolic acids, which represent the major constituent of mycobacterial cell wall complex, act as substrates [catalytic activity: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L- homocysteine + phospholipid cyclopropane fatty acid]; cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 993237 cmaA2 6225081 cmaA2 Mycobacterium marinum M cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 YP_001849146.1 992326 R 216594 CDS YP_001849147.1 183980856 6225082 complement(993260..993760) 1 NC_010612.1 hypothetical protein 993760 6225082 MMAR_0832 Mycobacterium marinum M hypothetical protein YP_001849147.1 993260 R 216594 CDS YP_001849148.1 183980857 6225083 complement(993805..994716) 1 NC_010612.1 removes a phosphate from phosphoserine [catalytic activity: phosphoserine + H2O = serine + phosphate]; phosphoserine phosphatase SerB1 994716 serB1 6225083 serB1 Mycobacterium marinum M phosphoserine phosphatase SerB1 YP_001849148.1 993805 R 216594 CDS YP_001849149.1 183980858 6225084 994905..995507 1 NC_010612.1 involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase small chain CoxS 995507 coxS_1 6225084 coxS_1 Mycobacterium marinum M carbon monoxyde dehydrogenase small chain CoxS YP_001849149.1 994905 D 216594 CDS YP_001849150.1 183980859 6225085 995511..996488 1 NC_010612.1 function unknown, probably involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase medium chain CoxM 996488 coxM_1 6225085 coxM_1 Mycobacterium marinum M carbon monoxyde dehydrogenase medium chain CoxM YP_001849150.1 995511 D 216594 CDS YP_001849151.1 183980860 6225086 996485..998662 1 NC_010612.1 involved in cellular metabolism [catalytic activity: CO + H(2)O + acceptor = CO(2) + reduced acceptor]; carbon monoxyde dehydrogenase large chain CoxL 998662 coxL_1 6225086 coxL_1 Mycobacterium marinum M carbon monoxyde dehydrogenase large chain CoxL YP_001849151.1 996485 D 216594 CDS YP_001849152.1 183980861 6225087 complement(998702..1000447) 1 NC_010612.1 PE-PGRS family protein 1000447 6225087 MMAR_0837 Mycobacterium marinum M PE-PGRS family protein YP_001849152.1 998702 R 216594 CDS YP_001849153.1 183980862 6225088 complement(1000885..1001679) 1 NC_010612.1 hypothetical protein 1001679 6225088 MMAR_0838 Mycobacterium marinum M hypothetical protein YP_001849153.1 1000885 R 216594 CDS YP_001849154.1 183980863 6225089 complement(1001852..1002403) 1 NC_010612.1 Transposon insertion in this sequence results in intracellular replication deficiency; macrophage infection protein, MimJ 1002403 mimJ 6225089 mimJ Mycobacterium marinum M macrophage infection protein, MimJ YP_001849154.1 1001852 R 216594 CDS YP_001849155.1 183980864 6225090 1002351..1002788 1 NC_010612.1 MmpS-family membrane protein 1002788 6225090 MMAR_0839 Mycobacterium marinum M MmpS-family membrane protein YP_001849155.1 1002351 D 216594 CDS YP_001849156.1 183980865 6225091 1002785..1005778 1 NC_010612.1 thought to be involved in fatty acid transport; transmembrane transport protein MmpL 1005778 mmpL2 6225091 mmpL2 Mycobacterium marinum M transmembrane transport protein MmpL YP_001849156.1 1002785 D 216594 CDS YP_001849157.1 183980866 6225092 1005778..1006053 1 NC_010612.1 hypothetical protein 1006053 6225092 MMAR_0841 Mycobacterium marinum M hypothetical protein YP_001849157.1 1005778 D 216594 CDS YP_001849158.1 183980867 6225093 1006164..1007585 1 NC_010612.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1007585 hemA 6225093 hemA Mycobacterium marinum M glutamyl-tRNA reductase YP_001849158.1 1006164 D 216594 CDS YP_001849159.1 183980868 6225094 1007599..1008543 1 NC_010612.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 1008543 hemC 6225094 hemC Mycobacterium marinum M porphobilinogen deaminase YP_001849159.1 1007599 D 216594 CDS YP_001849160.1 183980869 6225095 1008565..1010241 1 NC_010612.1 possibly involved in the biosynthesis of siroheme and cobalamin [catalytic activity: 2 S-adenosyl-L- methionine + uroporphyrin III = 2 S-adenosyl-L- homocysteine + sirohydrochlorin]; uroporphyrin-III C-methyltransferase HemD 1010241 hemD 6225095 hemD Mycobacterium marinum M uroporphyrin-III C-methyltransferase HemD YP_001849160.1 1008565 D 216594 CDS YP_001849161.1 183980870 6225096 1010281..1011264 1 NC_010612.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 1011264 hemB 6225096 hemB Mycobacterium marinum M delta-aminolevulinic acid dehydratase YP_001849161.1 1010281 D 216594 CDS YP_001849162.1 183980871 6225097 1011276..1011812 1 NC_010612.1 transmembrane protein 1011812 6225097 MMAR_0846 Mycobacterium marinum M transmembrane protein YP_001849162.1 1011276 D 216594 CDS YP_001849163.1 183980872 6225098 1011809..1012093 1 NC_010612.1 transmembrane protein 1012093 6225098 MMAR_0847 Mycobacterium marinum M transmembrane protein YP_001849163.1 1011809 D 216594 CDS YP_001849164.1 183980873 6225100 complement(1012526..1038805) 1 NC_010612.1 function unknown. contains 8 predicted modules, each with a minimum domain complement (C, a & T domains), responsible for the synthesis of an 8 amino acid metabolite. predicted sequential condensation of the following amino acids: F, R or F, F, T, F, F or C, L, F and followed by an integral thioesterase domain; non-ribosomal peptide synthetase 1038805 6225100 MMAR_0851 Mycobacterium marinum M non-ribosomal peptide synthetase YP_001849164.1 1012526 R 216594 CDS YP_001849165.1 183980874 6225101 complement(1040059..1041483) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. some have been shown to bind tightly to a range of azole-based antifungal drugs (E.G. miconazole, clotrimazole); cytochrome P450 185A4 Cyp185A4 1041483 cyp185A4 6225101 cyp185A4 Mycobacterium marinum M cytochrome P450 185A4 Cyp185A4 YP_001849165.1 1040059 R 216594 CDS YP_001849166.1 183980875 6225102 complement(1042445..1042894) 1 NC_010612.1 hypothetical protein 1042894 6225102 MMAR_0853 Mycobacterium marinum M hypothetical protein YP_001849166.1 1042445 R 216594 CDS YP_001849167.1 183980876 6225103 1043117..1044436 1 NC_010612.1 membrane acyltransferase 1044436 6225103 MMAR_0854 Mycobacterium marinum M membrane acyltransferase YP_001849167.1 1043117 D 216594 CDS YP_001849168.1 183980877 6225104 1044542..1045273 1 NC_010612.1 function unknown, domain identity to secreted hydrolases of the SgnH_hydrolase subfamily; hypothetical protein 1045273 6225104 MMAR_0855 Mycobacterium marinum M hypothetical protein YP_001849168.1 1044542 D 216594 CDS YP_001849169.1 183980878 6225105 complement(1045343..1045459) 1 NC_010612.1 hypothetical protein 1045459 6225105 MMAR_0856 Mycobacterium marinum M hypothetical protein YP_001849169.1 1045343 R 216594 CDS YP_001849170.1 183980879 6225106 complement(1045571..1047733) 1 NC_010612.1 transmembrane acyltransferase 1047733 6225106 MMAR_0857 Mycobacterium marinum M transmembrane acyltransferase YP_001849170.1 1045571 R 216594 CDS YP_001849171.1 183980880 6225107 complement(1047785..1048729) 1 NC_010612.1 has homology to a putative esterase domain; hypothetical protein 1048729 6225107 MMAR_0858 Mycobacterium marinum M hypothetical protein YP_001849171.1 1047785 R 216594 CDS YP_001849172.1 183980881 6225108 1048882..1049745 1 NC_010612.1 the universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general 'stress endurance' activity; universal stress protein UspA 1049745 6225108 MMAR_0859 Mycobacterium marinum M universal stress protein UspA YP_001849172.1 1048882 D 216594 CDS YP_001849173.1 183980882 6225109 1049868..1052585 1 NC_010612.1 metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation(out); metal cation-transporting p-type ATPase F, CtpF 1052585 ctpF 6225109 ctpF Mycobacterium marinum M metal cation-transporting p-type ATPase F, CtpF YP_001849173.1 1049868 D 216594 CDS YP_001849174.1 183980883 6225110 1052856..1054544 1 NC_010612.1 contains a UbiE domain: methylase involved in ubiquinone/menaquinone biosynthesis; glycine-sarcosine methyltransferase 1054544 6225110 MMAR_0861 Mycobacterium marinum M glycine-sarcosine methyltransferase YP_001849174.1 1052856 D 216594 CDS YP_001849175.1 183980884 6225111 1054714..1056039 1 NC_010612.1 involved in 4-aminobutyrate (GabA) degradation pathway. transporter for GabA. responsible for the translocation of the substrate across the membrane; gamma-aminobutyrate permease GabP 1056039 gabP 6225111 gabP Mycobacterium marinum M gamma-aminobutyrate permease GabP YP_001849175.1 1054714 D 216594 CDS YP_001849176.1 183980885 6225112 complement(1056046..1056978) 1 NC_010612.1 ketopantoate reductase PanE/ApbA. this is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases. the reaction catalysed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and pane are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway; ketopantoate reductase, ApbA 1056978 apbA 6225112 apbA Mycobacterium marinum M ketopantoate reductase, ApbA YP_001849176.1 1056046 R 216594 CDS YP_001849177.1 183980886 6225113 complement(1056994..1058151) 1 NC_010612.1 mandelate racemase 1058151 6225113 MMAR_0864 Mycobacterium marinum M mandelate racemase YP_001849177.1 1056994 R 216594 CDS YP_001849178.1 183980887 6225114 1058364..1058711 1 NC_010612.1 hypothetical protein 1058711 6225114 MMAR_0866 Mycobacterium marinum M hypothetical protein YP_001849178.1 1058364 D 216594 CDS YP_001849179.1 183980888 6225115 complement(1058708..1059007) 1 NC_010612.1 contains glutaredoxin domain; hypothetical protein 1059007 6225115 MMAR_0867 Mycobacterium marinum M hypothetical protein YP_001849179.1 1058708 R 216594 CDS YP_001849180.1 183980889 6225116 complement(1059110..1060453) 1 NC_010612.1 hypothetical protein 1060453 6225116 MMAR_0868 Mycobacterium marinum M hypothetical protein YP_001849180.1 1059110 R 216594 CDS YP_001849181.1 183980890 6225117 1060625..1061962 1 NC_010612.1 amino acid permease 1061962 6225117 MMAR_0869 Mycobacterium marinum M amino acid permease YP_001849181.1 1060625 D 216594 CDS YP_001849182.1 183980891 6225118 1062036..1063367 1 NC_010612.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 1063367 hemL 6225118 hemL Mycobacterium marinum M glutamate-1-semialdehyde aminotransferase YP_001849182.1 1062036 D 216594 CDS YP_001849183.1 183980892 6225119 1063367..1063975 1 NC_010612.1 contains fructose-2,6-bisphosphatase domain [carbohydrate transport and metabolism]; hypothetical protein 1063975 6225119 MMAR_0871 Mycobacterium marinum M hypothetical protein YP_001849183.1 1063367 D 216594 CDS YP_001849184.1 183980893 6225120 1063978..1064589 1 NC_010612.1 thioredoxin protein 1064589 6225120 MMAR_0872 Mycobacterium marinum M thioredoxin protein YP_001849184.1 1063978 D 216594 CDS YP_001849185.1 183980894 6225121 1064586..1065377 1 NC_010612.1 required during cytochrome biogenesis at the step of HemE attachment; cytochrome C-type biogenesis protein, CcsA 1065377 ccsA 6225121 ccsA Mycobacterium marinum M cytochrome C-type biogenesis protein, CcsA YP_001849185.1 1064586 D 216594 CDS YP_001849186.1 183980895 6225122 1065479..1067053 1 NC_010612.1 required for cytochrome C biosynthesis; ResB-family protein 1067053 6225122 MMAR_0874 Mycobacterium marinum M ResB-family protein YP_001849186.1 1065479 D 216594 CDS YP_001849187.1 183980896 6225123 1067050..1068036 1 NC_010612.1 required during cytochrome biogenesis at the step of HemE attachment; cytochrome C-type biogenesis protein, CcsB 1068036 ccsB 6225123 ccsB Mycobacterium marinum M cytochrome C-type biogenesis protein, CcsB YP_001849187.1 1067050 D 216594 CDS YP_001849188.1 183980897 6225124 1068078..1069394 1 NC_010612.1 hypothetical protein 1069394 6225124 MMAR_0876 Mycobacterium marinum M hypothetical protein YP_001849188.1 1068078 D 216594 CDS YP_001849189.1 183980898 6225125 complement(1069400..1069552) 1 NC_010612.1 hypothetical protein 1069552 6225125 MMAR_0877 Mycobacterium marinum M hypothetical protein YP_001849189.1 1069400 R 216594 CDS YP_001849190.1 183980899 6225126 1069647..1069967 1 NC_010612.1 hypothetical protein 1069967 6225126 MMAR_0878 Mycobacterium marinum M hypothetical protein YP_001849190.1 1069647 D 216594 CDS YP_001849191.1 183980900 6225127 complement(1069975..1070982) 1 NC_010612.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1070982 fabH 6225127 fabH Mycobacterium marinum M 3-oxoacyl-ACP synthase YP_001849191.1 1069975 R 216594 CDS YP_001849192.1 183980901 6225128 complement(1071081..1071956) 1 NC_010612.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 1071956 menA 6225128 menA Mycobacterium marinum M 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_001849192.1 1071081 R 216594 CDS YP_001849193.1 183980902 6225129 1071997..1072791 1 NC_010612.1 Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate; 5'-methylthioadenosine phosphorylase 1072791 pnp 6225129 pnp Mycobacterium marinum M 5'-methylthioadenosine phosphorylase YP_001849193.1 1071997 D 216594 CDS YP_001849194.1 183980903 6225130 1072788..1073828 1 NC_010612.1 involved in galactose metabolism [catalytic activity: UDP-glucose = UDP-galactose]; UDP-glucose 4-epimerase 1073828 galE3 6225130 galE3 Mycobacterium marinum M UDP-glucose 4-epimerase YP_001849194.1 1072788 D 216594 CDS YP_001849195.1 183980904 6225131 complement(1073836..1075503) 1 NC_010612.1 hypothetical protein 1075503 6225131 MMAR_0883 Mycobacterium marinum M hypothetical protein YP_001849195.1 1073836 R 216594 CDS YP_001849196.1 183980905 6225132 1075815..1077746 1 NC_010612.1 hypothetical protein 1077746 6225132 MMAR_0884 Mycobacterium marinum M hypothetical protein YP_001849196.1 1075815 D 216594 CDS YP_001849197.1 183980906 6225133 1077776..1078432 1 NC_010612.1 substrate (sugar) unknown [catalytic activity: NDP- sugar + dolichyl phosphate = NDP + dolichyl sugar phosphate]; glycosyl transferase - dolichol-P-sugar synthase 1078432 6225133 MMAR_0885 Mycobacterium marinum M glycosyl transferase - dolichol-P-sugar synthase YP_001849197.1 1077776 D 216594 CDS YP_001849198.1 183980907 6225134 1078429..1079091 1 NC_010612.1 hypothetical protein 1079091 6225134 MMAR_0886 Mycobacterium marinum M hypothetical protein YP_001849198.1 1078429 D 216594 CDS YP_001849199.1 183980908 6225135 complement(1079123..1080475) 1 NC_010612.1 hypothetical protein 1080475 6225135 MMAR_0887 Mycobacterium marinum M hypothetical protein YP_001849199.1 1079123 R 216594 CDS YP_001849200.1 183980909 6225136 complement(1080487..1081596) 1 NC_010612.1 involved in menaquinone biosynthesis. O- succinylbenzoic acid (OSB) to O-succinylbenzoyl-CoA (OSB- CoA) [catalytic activity: ATP + O-succinylbenzoate + CoA = AMP + diphosphate + O-succinylbenzoyl-CoA]; O-succinylbenzoic acid--CoA ligase 1081596 menE 6225136 menE Mycobacterium marinum M O-succinylbenzoic acid--CoA ligase YP_001849200.1 1080487 R 216594 CDS YP_001849201.1 183980910 6225137 complement(1081641..1081937) 1 NC_010612.1 hypothetical protein 1081937 6225137 MMAR_0889 Mycobacterium marinum M hypothetical protein YP_001849201.1 1081641 R 216594 CDS YP_001849202.1 183980911 6225138 complement(1081998..1082282) 1 NC_010612.1 hypothetical protein 1082282 6225138 MMAR_0890 Mycobacterium marinum M hypothetical protein YP_001849202.1 1081998 R 216594 CDS YP_001849203.1 183980912 6225139 complement(1082279..1083556) 1 NC_010612.1 involved in low-affinity inorganic phosphate transport across the membrane. responsible for the translocation of the substrate across the membrane; low-affinity inorganic phosphate transporter, PitA 1083556 pitA 6225139 pitA Mycobacterium marinum M low-affinity inorganic phosphate transporter, PitA YP_001849203.1 1082279 R 216594 CDS YP_001849204.1 183980913 6225140 complement(1083654..1084061) 1 NC_010612.1 glyoxalase 1084061 6225140 MMAR_0892 Mycobacterium marinum M glyoxalase YP_001849204.1 1083654 R 216594 CDS YP_001849205.1 183980914 6225141 complement(1084075..1084704) 1 NC_010612.1 hypothetical protein 1084704 6225141 MMAR_0893 Mycobacterium marinum M hypothetical protein YP_001849205.1 1084075 R 216594 CDS YP_001849206.1 183980915 6225142 complement(1084723..1085610) 1 NC_010612.1 short chain dehydrogenase 1085610 6225142 MMAR_0894 Mycobacterium marinum M short chain dehydrogenase YP_001849206.1 1084723 R 216594 CDS YP_001849207.1 183980916 6225143 complement(1085654..1086556) 1 NC_010612.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 1086556 menB 6225143 menB Mycobacterium marinum M naphthoate synthase YP_001849207.1 1085654 R 216594 CDS YP_001849208.1 183980917 6225144 complement(1086553..1087254) 1 NC_010612.1 hypothetical protein 1087254 6225144 MMAR_0896 Mycobacterium marinum M hypothetical protein YP_001849208.1 1086553 R 216594 CDS YP_001849209.1 183980918 6225145 complement(1087364..1088965) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1088965 fadD8 6225145 fadD8 Mycobacterium marinum M acyl-CoA synthetase YP_001849209.1 1087364 R 216594 CDS YP_001849210.1 183980919 6225146 1089054..1090658 1 NC_010612.1 has significant domain identity to predicted metal- dependent hydrolases; hypothetical protein 1090658 6225146 MMAR_0898 Mycobacterium marinum M hypothetical protein YP_001849210.1 1089054 D 216594 CDS YP_001849211.1 183980920 6225147 1090655..1091638 1 NC_010612.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 1091638 menC 6225147 menC Mycobacterium marinum M O-succinylbenzoate synthase YP_001849211.1 1090655 D 216594 CDS YP_001849212.1 183980921 6225148 1091631..1092419 1 NC_010612.1 non-haem peroxidase; bromoperoxidase BpoC 1092419 bpoC 6225148 bpoC Mycobacterium marinum M bromoperoxidase BpoC YP_001849212.1 1091631 D 216594 CDS YP_001849213.1 183980922 6225149 1092483..1094129 1 NC_010612.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 1094129 menD 6225149 menD Mycobacterium marinum M 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_001849213.1 1092483 D 216594 CDS YP_001849214.1 183980923 6225150 1094126..1094650 1 NC_010612.1 hypothetical protein 1094650 6225150 MMAR_0902 Mycobacterium marinum M hypothetical protein YP_001849214.1 1094126 D 216594 CDS YP_001849215.1 183980924 6225151 1094726..1095877 1 NC_010612.1 involved in lipoarabinomannan (lam) biosynthesis; mannosyltransferase, PimB 1095877 pimB 6225151 pimB Mycobacterium marinum M mannosyltransferase, PimB YP_001849215.1 1094726 D 216594 CDS YP_001849216.1 183980925 6225152 complement(1095874..1096476) 1 NC_010612.1 mar family; transcriptional regulator 1096476 6225152 MMAR_0904 Mycobacterium marinum M transcriptional regulator YP_001849216.1 1095874 R 216594 CDS YP_001849217.1 183980926 6225153 1096505..1097680 1 NC_010612.1 hypothetical protein 1097680 6225153 MMAR_0905 Mycobacterium marinum M hypothetical protein YP_001849217.1 1096505 D 216594 CDS YP_001849218.1 183980927 6225154 1097670..1098977 1 NC_010612.1 hypothetical protein 1098977 6225154 MMAR_0906 Mycobacterium marinum M hypothetical protein YP_001849218.1 1097670 D 216594 CDS YP_001849219.1 183980928 6225155 1099006..1099701 1 NC_010612.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 1099701 ubiE 6225155 ubiE Mycobacterium marinum M ubiquinone/menaquinone biosynthesis methyltransferase YP_001849219.1 1099006 D 216594 CDS YP_001849220.1 183980929 6225156 complement(1099720..1100055) 1 NC_010612.1 hypothetical protein 1100055 6225156 MMAR_0908 Mycobacterium marinum M hypothetical protein YP_001849220.1 1099720 R 216594 CDS YP_001849221.1 183980930 6225157 complement(1100088..1100777) 1 NC_010612.1 methyltransferase 1100777 6225157 MMAR_0909 Mycobacterium marinum M methyltransferase YP_001849221.1 1100088 R 216594 CDS YP_001849222.1 183980931 6225158 complement(1100831..1102069) 1 NC_010612.1 has significant domain conservation with dehydrogenases (flavoproteins) [energy production and conversion]; FAD-linked oxidoreductase 1102069 6225158 MMAR_0910 Mycobacterium marinum M FAD-linked oxidoreductase YP_001849222.1 1100831 R 216594 CDS YP_001849223.1 183980932 6225159 1102091..1103098 1 NC_010612.1 supplies polyprenyl diphosphate; polyprenyl diphosphate synthetase, GrcC1 1103098 grcC1 6225159 grcC1 Mycobacterium marinum M polyprenyl diphosphate synthetase, GrcC1 YP_001849223.1 1102091 D 216594 CDS YP_001849224.1 183980933 6225160 1103189..1104049 1 NC_010612.1 putative metalloprotease; heat shock protein HtpX 1104049 hspX 6225160 hspX Mycobacterium marinum M heat shock protein HtpX YP_001849224.1 1103189 D 216594 CDS YP_001849225.1 183980934 6225161 complement(1104070..1105671) 1 NC_010612.1 generates CO(2) and H(2)O from H(2)CO(3), and possibly involved in transport of sulfate across the membrane; transmembrane carbonic anhydrase, SulP 1105671 sulP 6225161 sulP Mycobacterium marinum M transmembrane carbonic anhydrase, SulP YP_001849225.1 1104070 R 216594 CDS YP_001849226.1 183980935 6225162 complement(1105964..1107517) 1 NC_010612.1 transmembrane carbonic anhydrase, SulP 1107517 sulP_1 6225162 sulP_1 Mycobacterium marinum M transmembrane carbonic anhydrase, SulP YP_001849226.1 1105964 R 216594 CDS YP_001849227.1 183980936 6225163 complement(1107750..1108775) 1 NC_010612.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1108775 gpdA1 6225163 gpdA1 Mycobacterium marinum M NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_001849227.1 1107750 R 216594 CDS YP_001849228.1 183980937 6225164 1108935..1110431 1 NC_010612.1 hydrolyzes peptides and/or proteins. cleaves preferentially after serine residues; trypsin-like serine protease 1110431 6225164 MMAR_0916 Mycobacterium marinum M trypsin-like serine protease YP_001849228.1 1108935 D 216594 CDS YP_001849229.1 183980938 6225165 complement(1110460..1111968) 1 NC_010612.1 function unknown but domain identity suggests this CDS encodes a flavoprotein involved in K+ transport; flavin-binding monooxygenase 1111968 6225165 MMAR_0917 Mycobacterium marinum M flavin-binding monooxygenase YP_001849229.1 1110460 R 216594 CDS YP_001849230.1 183980939 6225166 complement(1112418..1115708) 1 NC_010612.1 function unknown; the lantibiotics are a group of ribosomally synthesised, post-translationally modified peptides containing unusual amino acids, such as dehydrated and lanthionine residuesthe lantibiotics are a group of ribosomally synthesised, post-translationally modified peptides containing unusual amino acids, such as dehydrated and lanthionine residues; lantibiotic modifying enzyme 1115708 6225166 MMAR_0918 Mycobacterium marinum M lantibiotic modifying enzyme YP_001849230.1 1112418 R 216594 CDS YP_001849231.1 183980940 6225167 complement(1115857..1116393) 1 NC_010612.1 domain identity to N-acetylases of ribosomal proteins; acetyltransferase, RimL 1116393 rimL 6225167 rimL Mycobacterium marinum M acetyltransferase, RimL YP_001849231.1 1115857 R 216594 CDS YP_001849232.1 183980941 6225168 complement(1116495..1116986) 1 NC_010612.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 1116986 6225168 MMAR_0920 Mycobacterium marinum M putative nucleotide-binding protein YP_001849232.1 1116495 R 216594 CDS YP_001849233.1 183980942 6225170 complement(1117179..1119563) 1 NC_010612.1 ABC-type transport system, involved in lipoprotein release, permease component; ABC transporter 1119563 6225170 MMAR_0921 Mycobacterium marinum M ABC transporter YP_001849233.1 1117179 R 216594 CDS YP_001849234.1 183980943 6225171 complement(1119560..1120294) 1 NC_010612.1 ABC transporter ATP-binding protein 1120294 6225171 MMAR_0922 Mycobacterium marinum M ABC transporter ATP-binding protein YP_001849234.1 1119560 R 216594 CDS YP_001849235.1 183980944 6225172 complement(1120291..1120896) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulator 1120896 6225172 MMAR_0923 Mycobacterium marinum M transcriptional regulator YP_001849235.1 1120291 R 216594 CDS YP_001849236.1 183980945 6225173 complement(1121019..1121831) 1 NC_010612.1 carveol-like dehydrogenase 1121831 6225173 MMAR_0924 Mycobacterium marinum M carveol-like dehydrogenase YP_001849236.1 1121019 R 216594 CDS YP_001849237.1 183980946 6225174 complement(1121953..1123173) 1 NC_010612.1 NhaP-type Na+/H+ and K+/H+ antiporter: inorganic ion transport and metabolism]. antiporters are ubiquitous membrane proteins that are involved in homeostasis of H(+) and na(+) throughout the biological kingdom; ion antiporter, NhaP 1123173 nhaP 6225174 nhaP Mycobacterium marinum M ion antiporter, NhaP YP_001849237.1 1121953 R 216594 CDS YP_001849238.1 183980947 6225175 complement(1123331..1125532) 1 NC_010612.1 PPE family protein 1125532 6225175 MMAR_0926 Mycobacterium marinum M PPE family protein YP_001849238.1 1123331 R 216594 CDS YP_001849239.1 183980948 6225176 1125902..1126099 1 NC_010612.1 hypothetical protein 1126099 6225176 MMAR_0927 Mycobacterium marinum M hypothetical protein YP_001849239.1 1125902 D 216594 CDS YP_001849240.1 183980949 6225177 complement(1126116..1127336) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 189A6 Cyp189A6 1127336 cyp189A6 6225177 cyp189A6 Mycobacterium marinum M cytochrome P450 189A6 Cyp189A6 YP_001849240.1 1126116 R 216594 CDS YP_001849241.1 183980950 6225178 1127453..1128076 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 1128076 6225178 MMAR_0929 Mycobacterium marinum M TetR family transcriptional regulator YP_001849241.1 1127453 D 216594 CDS YP_001849242.1 183980951 6225179 complement(1128147..1128977) 1 NC_010612.1 involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB; transcriptional regulatory protein EmbR_2 1128977 embR_2 6225179 embR_2 Mycobacterium marinum M transcriptional regulatory protein EmbR_2 YP_001849242.1 1128147 R 216594 CDS YP_001849243.1 183980952 6225180 1129286..1130005 1 NC_010612.1 hypothetical protein 1130005 6225180 MMAR_0931 Mycobacterium marinum M hypothetical protein YP_001849243.1 1129286 D 216594 CDS YP_001849244.1 183980953 6225181 1130299..1133964 1 NC_010612.1 PPE family protein 1133964 6225181 MMAR_0932 Mycobacterium marinum M PPE family protein YP_001849244.1 1130299 D 216594 CDS YP_001849245.1 183980954 6225182 1133992..1134357 1 NC_010612.1 hypothetical protein 1134357 6225182 MMAR_0933 Mycobacterium marinum M hypothetical protein YP_001849245.1 1133992 D 216594 CDS YP_001849246.1 183980955 6225183 1134462..1135484 1 NC_010612.1 methyltransferase/methylase 1135484 6225183 MMAR_0934 Mycobacterium marinum M methyltransferase/methylase YP_001849246.1 1134462 D 216594 CDS YP_001849247.1 183980956 6225184 1135532..1136356 1 NC_010612.1 adenylate cyclase 1136356 6225184 MMAR_0935 Mycobacterium marinum M adenylate cyclase YP_001849247.1 1135532 D 216594 CDS YP_001849248.1 183980957 6225185 1136481..1138823 1 NC_010612.1 arylsulfatase AtsA 1138823 atsA_1 6225185 atsA_1 Mycobacterium marinum M arylsulfatase AtsA YP_001849248.1 1136481 D 216594 CDS YP_001849249.1 183980958 6225186 1138893..1140395 1 NC_010612.1 component of the translational apparatus. furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. the reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-glu-tRNA(Gln) [catalytic activity: ATP + L-glutamyl-tRNA(Gln) + L- glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L- glutamate]; peptide amidase, GatA 1140395 gatA_1 6225186 gatA_1 Mycobacterium marinum M peptide amidase, GatA YP_001849249.1 1138893 D 216594 CDS YP_001849250.1 183980959 6225187 1140594..1141985 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 135B4 Cyp135B4 1141985 cyp135B4 6225187 cyp135B4 Mycobacterium marinum M cytochrome P450 135B4 Cyp135B4 YP_001849250.1 1140594 D 216594 CDS YP_001849251.1 183980960 6225188 complement(1141970..1143139) 1 NC_010612.1 hypothetical protein 1143139 6225188 MMAR_0939 Mycobacterium marinum M hypothetical protein YP_001849251.1 1141970 R 216594 CDS YP_001849252.1 183980961 6225189 1143252..1144328 1 NC_010612.1 involved in galactose metabolism (Leloir pathway) [catalytic activity: UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-galactose]; galactose-1-phosphate uridylyltransferase 1144328 galT 6225189 galT Mycobacterium marinum M galactose-1-phosphate uridylyltransferase YP_001849252.1 1143252 D 216594 CDS YP_001849253.1 183980962 6225190 1144325..1145425 1 NC_010612.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 1145425 galK 6225190 galK Mycobacterium marinum M galactokinase YP_001849253.1 1144325 D 216594 CDS YP_001849254.1 183980963 6225191 1145506..1146528 1 NC_010612.1 ArsR family; transcriptional regulator 1146528 6225191 MMAR_0942 Mycobacterium marinum M transcriptional regulator YP_001849254.1 1145506 D 216594 CDS YP_001849255.1 183980964 6225192 complement(1146525..1150802) 1 NC_010612.1 PE-PGRS family protein 1150802 6225192 MMAR_0943 Mycobacterium marinum M PE-PGRS family protein YP_001849255.1 1146525 R 216594 CDS YP_001849256.1 183980965 6225193 1151102..1151905 1 NC_010612.1 hypothetical protein 1151905 6225193 MMAR_0944 Mycobacterium marinum M hypothetical protein YP_001849256.1 1151102 D 216594 CDS YP_001849257.1 183980966 6225194 complement(1151948..1154224) 1 NC_010612.1 hypothetical protein 1154224 6225194 MMAR_0945 Mycobacterium marinum M hypothetical protein YP_001849257.1 1151948 R 216594 CDS YP_001849258.1 183980967 6225195 1154343..1155116 1 NC_010612.1 hypothetical protein 1155116 6225195 MMAR_0946 Mycobacterium marinum M hypothetical protein YP_001849258.1 1154343 D 216594 CDS YP_001849259.1 183980968 6225196 complement(1155091..1156611) 1 NC_010612.1 contains hydrolase domain; hypothetical protein 1156611 6225196 MMAR_0947 Mycobacterium marinum M hypothetical protein YP_001849259.1 1155091 R 216594 CDS YP_001849260.1 183980969 6225197 complement(1156673..1157158) 1 NC_010612.1 hypothetical protein 1157158 6225197 MMAR_0948 Mycobacterium marinum M hypothetical protein YP_001849260.1 1156673 R 216594 CDS YP_001849261.1 183980970 6225198 complement(1157272..1158567) 1 NC_010612.1 lipoprotein LppF 1158567 lppF 6225198 lppF Mycobacterium marinum M lipoprotein LppF YP_001849261.1 1157272 R 216594 CDS YP_001849262.1 183980971 6225199 complement(1158771..1159457) 1 NC_010612.1 lipoprotein LpqN 1159457 lpqN 6225199 lpqN Mycobacterium marinum M lipoprotein LpqN YP_001849262.1 1158771 R 216594 CDS YP_001849263.1 183980972 6225200 1159548..1159697 1 NC_010612.1 hypothetical protein 1159697 6225200 MMAR_0951 Mycobacterium marinum M hypothetical protein YP_001849263.1 1159548 D 216594 CDS YP_001849264.1 183980973 6225201 1159708..1162347 1 NC_010612.1 function unknown role incarbohydrate transport and metabolism; alpha-1,2-mannosidase 1162347 6225201 MMAR_0952 Mycobacterium marinum M alpha-1,2-mannosidase YP_001849264.1 1159708 D 216594 CDS YP_001849265.1 183980974 6225202 complement(1162370..1164745) 1 NC_010612.1 integral membrane protein 1164745 6225202 MMAR_0953 Mycobacterium marinum M integral membrane protein YP_001849265.1 1162370 R 216594 CDS YP_001849266.1 183980975 6225204 complement(1165242..1166504) 1 NC_010612.1 function unknown, imidazolonepropionase is an amidohydrolase; imidazolonepropionase 1166504 6225204 MMAR_0954 Mycobacterium marinum M imidazolonepropionase YP_001849266.1 1165242 R 216594 CDS YP_001849267.1 183980976 6225205 1166636..1167577 1 NC_010612.1 hypothetical protein 1167577 6225205 MMAR_0955 Mycobacterium marinum M hypothetical protein YP_001849267.1 1166636 D 216594 CDS YP_001849268.1 183980977 6225206 complement(1167598..1169361) 1 NC_010612.1 involved in homologous recombination; exodeoxyribonuclease V (alpha chain), RecD 1169361 recD 6225206 recD Mycobacterium marinum M exodeoxyribonuclease V (alpha chain), RecD YP_001849268.1 1167598 R 216594 CDS YP_001849269.1 183980978 6225207 complement(1169358..1172690) 1 NC_010612.1 involved in homologous recombination; exodeoxyribonuclease V (beta chain), RecB 1172690 recB 6225207 recB Mycobacterium marinum M exodeoxyribonuclease V (beta chain), RecB YP_001849269.1 1169358 R 216594 CDS YP_001849270.1 183980979 6225208 complement(1172690..1175989) 1 NC_010612.1 involved in homologous recombination; exodeoxyribonuclease V (gamma chain), RecC 1175989 recC 6225208 recC Mycobacterium marinum M exodeoxyribonuclease V (gamma chain), RecC YP_001849270.1 1172690 R 216594 CDS YP_001849271.1 183980980 6225209 1176040..1176555 1 NC_010612.1 nitroreductase 1176555 6225209 MMAR_0959 Mycobacterium marinum M nitroreductase YP_001849271.1 1176040 D 216594 CDS YP_001849272.1 183980981 6225210 1176629..1177105 1 NC_010612.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 1177105 cynS 6225210 cynS Mycobacterium marinum M cyanate hydratase YP_001849272.1 1176629 D 216594 CDS YP_001849273.1 183980982 6225211 1177128..1178132 1 NC_010612.1 function unknown; predicted esterase domains; hypothetical protein 1178132 6225211 MMAR_0961 Mycobacterium marinum M hypothetical protein YP_001849273.1 1177128 D 216594 CDS YP_001849274.1 183980983 6225212 complement(1178161..1178856) 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1178856 echA3 6225212 echA3 Mycobacterium marinum M enoyl-CoA hydratase YP_001849274.1 1178161 R 216594 CDS YP_001849275.1 183980984 6225213 complement(1178938..1179768) 1 NC_010612.1 hypothetical protein 1179768 6225213 MMAR_0963 Mycobacterium marinum M hypothetical protein YP_001849275.1 1178938 R 216594 CDS YP_001849276.1 183980985 6225214 complement(1179962..1180678) 1 NC_010612.1 thought to be involved in glyoxal pathway. thioesterase that catalyses the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid [catalytic activity: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy acid anion]; glyoxalase II, GloB 1180678 gloB 6225214 gloB Mycobacterium marinum M glyoxalase II, GloB YP_001849276.1 1179962 R 216594 CDS YP_001849277.1 183980986 6225215 1180811..1181020 1 NC_010612.1 domain homology to Arc/MetJ class transcription regulators; hypothetical protein 1181020 6225215 MMAR_0966 Mycobacterium marinum M hypothetical protein YP_001849277.1 1180811 D 216594 CDS YP_001849278.1 183980987 6225218 1181408..1181575 1 NC_010612.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 1181575 rpmG 6225218 rpmG Mycobacterium marinum M 50S ribosomal protein L33 YP_001849278.1 1181408 D 216594 CDS YP_001849279.1 183980988 6225219 1181626..1182105 1 NC_010612.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadA 1182105 6225219 MMAR_0968 Mycobacterium marinum M (3R)-hydroxyacyl-ACP dehydratase subunit HadA YP_001849279.1 1181626 D 216594 CDS YP_001849280.1 183980989 6225220 1182092..1182520 1 NC_010612.1 functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadB 1182520 6225220 MMAR_0969 Mycobacterium marinum M (3R)-hydroxyacyl-ACP dehydratase subunit HadB YP_001849280.1 1182092 D 216594 CDS YP_001849281.1 183980990 6225221 1182531..1183031 1 NC_010612.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadC 1183031 6225221 MMAR_0970 Mycobacterium marinum M (3R)-hydroxyacyl-ACP dehydratase subunit HadC YP_001849281.1 1182531 D 216594 CDS YP_001849282.1 183980991 6225223 1183400..1183888 1 NC_010612.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1183888 secE 6225223 secE Mycobacterium marinum M preprotein translocase subunit SecE YP_001849282.1 1183400 D 216594 CDS YP_001849283.1 183980992 6225224 1183920..1184633 1 NC_010612.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 1184633 nusG 6225224 nusG Mycobacterium marinum M transcription antitermination protein NusG YP_001849283.1 1183920 D 216594 CDS YP_001849284.1 183980993 6225225 1184680..1185108 1 NC_010612.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 1185108 rplK 6225225 rplK Mycobacterium marinum M 50S ribosomal protein L11 YP_001849284.1 1184680 D 216594 CDS YP_001849285.1 183980994 6225226 1185196..1185903 1 NC_010612.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 1185903 rplA 6225226 rplA Mycobacterium marinum M 50S ribosomal protein L1 YP_001849285.1 1185196 D 216594 CDS YP_001849286.1 183980995 6225227 complement(1185990..1187216) 1 NC_010612.1 RNA polymerase sigma factor 1187216 6225227 MMAR_0975 Mycobacterium marinum M RNA polymerase sigma factor YP_001849286.1 1185990 R 216594 CDS YP_001849287.1 183980996 6225228 complement(1187232..1187930) 1 NC_010612.1 May play a role in initiation of transcription; hypothetical protein 1187930 6225228 MMAR_0976 Mycobacterium marinum M hypothetical protein YP_001849287.1 1187232 R 216594 CDS YP_001849288.1 183980997 6225229 complement(1188035..1188934) 1 NC_010612.1 methyltransferase. involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine- dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase; methoxy mycolic acid synthase 4, MmaA4 1188934 mmaA4 6225229 mmaA4 Mycobacterium marinum M methoxy mycolic acid synthase 4, MmaA4 YP_001849288.1 1188035 R 216594 CDS YP_001849289.1 183980998 6225230 complement(1189077..1189958) 1 NC_010612.1 methyltransferase involved in mycolic acid biosynthesis; methoxy mycolic acid synthase 3, MmaA3 1189958 mmaA3 6225230 mmaA3 Mycobacterium marinum M methoxy mycolic acid synthase 3, MmaA3 YP_001849289.1 1189077 R 216594 CDS YP_001849290.1 183980999 6225231 complement(1190091..1190957) 1 NC_010612.1 involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine-dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase; methoxy mycolic acid synthase 5 MmaA5 1190957 mmaA5_1 6225231 mmaA5_1 Mycobacterium marinum M methoxy mycolic acid synthase 5 MmaA5 YP_001849290.1 1190091 R 216594 CDS YP_001849291.1 183981000 6225232 complement(1191104..1191964) 1 NC_010612.1 involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine-dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase; methoxy mycolic acid synthase 1 Mma1 1191964 mmaA1 6225232 mmaA1 Mycobacterium marinum M methoxy mycolic acid synthase 1 Mma1 YP_001849291.1 1191104 R 216594 CDS YP_001849292.1 183981001 6225233 complement(1192061..1193005) 1 NC_010612.1 lipase/esterase 1193005 lipG1 6225233 lipG1 Mycobacterium marinum M lipase/esterase YP_001849292.1 1192061 R 216594 CDS YP_001849293.1 183981002 6225234 complement(1193015..1194400) 1 NC_010612.1 contains a kinase domain and ATP-binding cassette; hypothetical protein 1194400 6225234 MMAR_0982 Mycobacterium marinum M hypothetical protein YP_001849293.1 1193015 R 216594 CDS YP_001849294.1 183981003 6225235 complement(1194520..1195449) 1 NC_010612.1 lipase/esterase 1195449 lipG2 6225235 lipG2 Mycobacterium marinum M lipase/esterase YP_001849294.1 1194520 R 216594 CDS YP_001849295.1 183981004 6225236 complement(1195500..1196900) 1 NC_010612.1 amidase 1196900 amiD 6225236 amiD Mycobacterium marinum M amidase YP_001849295.1 1195500 R 216594 CDS YP_001849296.1 183981005 6225237 1197027..1201226 1 NC_010612.1 alpha-mannosidase activity: hydrolysis of terminal non-reducing alpha-D-mannose residues in alpha-D- mannosides; alpha-mannosidase 1201226 6225237 MMAR_0985 Mycobacterium marinum M alpha-mannosidase YP_001849296.1 1197027 D 216594 CDS YP_001849297.1 183981006 6225238 1201223..1201840 1 NC_010612.1 involved in lipid metabolism; fatty acid biosynthesis [catalytic activity: malonyl-CoA + [acyl- carrier protein] = CoA + malonyl-[acyl-carrier protein]]; malonyl CoA-acyl carrier protein transacylase, FabD2 1201840 fabD2 6225238 fabD2 Mycobacterium marinum M malonyl CoA-acyl carrier protein transacylase, FabD2 YP_001849297.1 1201223 D 216594 CDS YP_001849298.1 183981007 6225239 1201847..1202755 1 NC_010612.1 potential pseudogene due to C-term disruption by ISMyma04; function unknown; probably involved in specific sugar metabolism or regulation; carbohydrate kinase 1202755 6225239 MMAR_0987 Mycobacterium marinum M carbohydrate kinase YP_001849298.1 1201847 D 216594 CDS YP_001849299.1 183981008 6225240 complement(1202766..1203737) 1 NC_010612.1 transposition of ISMyma04; transposase for ISMyma04 1203737 6225240 MMAR_0988 Mycobacterium marinum M transposase for ISMyma04 YP_001849299.1 1202766 R 216594 CDS YP_001849300.1 183981009 6225241 1204266..1207418 1 NC_010612.1 PE-PGRS family protein 1207418 6225241 MMAR_0989 Mycobacterium marinum M PE-PGRS family protein YP_001849300.1 1204266 D 216594 CDS YP_001849301.1 183981010 6225242 1207793..1208413 1 NC_010612.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1208413 rplJ 6225242 rplJ Mycobacterium marinum M 50S ribosomal protein L10 YP_001849301.1 1207793 D 216594 CDS YP_001849302.1 183981011 6225243 1208481..1208873 1 NC_010612.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1208873 rplL 6225243 rplL Mycobacterium marinum M 50S ribosomal protein L7/L12 YP_001849302.1 1208481 D 216594 CDS YP_001849303.1 183981012 6225244 complement(1208937..1209674) 1 NC_010612.1 function unknown, involved in transcriptional mechanism; transcriptional regulatory protein 1209674 6225244 MMAR_0992 Mycobacterium marinum M transcriptional regulatory protein YP_001849303.1 1208937 R 216594 CDS YP_001849304.1 183981013 6225245 1209746..1211248 1 NC_010612.1 dioxygenase and related enzymes [secondary metabolites biosynthesis, transport, and catabolism]; dioxygenase 1211248 6225245 MMAR_0993 Mycobacterium marinum M dioxygenase YP_001849304.1 1209746 D 216594 CDS YP_001849305.1 183981014 6225246 1211427..1212413 1 NC_010612.1 thought to be involved in active transport of ribonucleotide across the membrane. responsible for energy coupling to the transport system; ribonucleotide-transport ATP-binding protein ABC transporter, Mkl 1212413 mkl 6225246 mkl Mycobacterium marinum M ribonucleotide-transport ATP-binding protein ABC transporter, Mkl YP_001849305.1 1211427 D 216594 CDS YP_001849306.1 183981015 6225247 1213006..1216536 1 NC_010612.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1216536 rpoB 6225247 rpoB Mycobacterium marinum M DNA-directed RNA polymerase subunit beta YP_001849306.1 1213006 D 216594 CDS YP_001849307.1 183981016 6225248 1216589..1220539 1 NC_010612.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 1220539 rpoC 6225248 rpoC Mycobacterium marinum M DNA-directed RNA polymerase subunit beta' YP_001849307.1 1216589 D 216594 CDS YP_001849308.1 183981017 6225249 1221202..1221393 1 NC_010612.1 PE-PGRS family protein 1221393 6225249 MMAR_5546 Mycobacterium marinum M PE-PGRS family protein YP_001849308.1 1221202 D 216594 CDS YP_001849309.1 183981018 6225250 complement(1221426..1223339) 1 NC_010612.1 ceramidase 1223339 6225250 MMAR_0997 Mycobacterium marinum M ceramidase YP_001849309.1 1221426 R 216594 CDS YP_001849310.1 183981019 6225251 1223537..1224403 1 NC_010612.1 hypothetical protein 1224403 6225251 MMAR_0998 Mycobacterium marinum M hypothetical protein YP_001849310.1 1223537 D 216594 CDS YP_001849311.1 183981020 6225252 1224484..1225242 1 NC_010612.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 1225242 end 6225252 end Mycobacterium marinum M endonuclease IV YP_001849311.1 1224484 D 216594 CDS YP_001849312.1 183981021 6225253 1225307..1226155 1 NC_010612.1 lipoprotein LpqP 1226155 lpqP 6225253 lpqP Mycobacterium marinum M lipoprotein LpqP YP_001849312.1 1225307 D 216594 CDS YP_001849313.1 183981022 6225254 1226217..1227845 1 NC_010612.1 may be involved in lipid degradation; acyl-CoA dehydrogenase 1227845 6225254 MMAR_1001 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001849313.1 1226217 D 216594 CDS YP_001849314.1 183981023 6225255 1227854..1228792 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1228792 echA4 6225255 echA4 Mycobacterium marinum M enoyl-CoA hydratase YP_001849314.1 1227854 D 216594 CDS YP_001849315.1 183981024 6225256 1228806..1229537 1 NC_010612.1 high domain identity with transcriptional repressors; putative regulatory protein 1229537 6225256 MMAR_1003 Mycobacterium marinum M putative regulatory protein YP_001849315.1 1228806 D 216594 CDS YP_001849316.1 183981025 6225257 1229534..1230307 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1230307 echA5 6225257 echA5 Mycobacterium marinum M enoyl-CoA hydratase YP_001849316.1 1229534 D 216594 CDS YP_001849317.1 183981026 6225258 complement(1230364..1233258) 1 NC_010612.1 thought to be involved in fatty acid transport; transmembrane transport protein MmpL 1233258 mmpL5 6225258 mmpL5 Mycobacterium marinum M transmembrane transport protein MmpL YP_001849317.1 1230364 R 216594 CDS YP_001849318.1 183981027 6225259 complement(1233255..1233683) 1 NC_010612.1 transmembrane proteinm, MmpS5 1233683 mmpS5 6225259 mmpS5 Mycobacterium marinum M transmembrane proteinm, MmpS5 YP_001849318.1 1233255 R 216594 CDS YP_001849319.1 183981028 6225260 1233867..1234367 1 NC_010612.1 transcriptional regulator 1234367 6225260 MMAR_1007 Mycobacterium marinum M transcriptional regulator YP_001849319.1 1233867 D 216594 CDS YP_001849320.1 183981029 6225261 complement(1234417..1234893) 1 NC_010612.1 hypothetical protein 1234893 6225261 MMAR_1008 Mycobacterium marinum M hypothetical protein YP_001849320.1 1234417 R 216594 CDS YP_001849321.1 183981030 6225262 complement(1234943..1235320) 1 NC_010612.1 hypothetical protein 1235320 6225262 MMAR_1009 Mycobacterium marinum M hypothetical protein YP_001849321.1 1234943 R 216594 CDS YP_001849322.1 183981031 6225263 1235584..1236231 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 1236231 6225263 MMAR_1010 Mycobacterium marinum M TetR family transcriptional regulator YP_001849322.1 1235584 D 216594 CDS YP_001849323.1 183981032 6225264 1236607..1236981 1 NC_010612.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 1236981 rpsL 6225264 rpsL Mycobacterium marinum M 30S ribosomal protein S12 YP_001849323.1 1236607 D 216594 CDS YP_001849324.1 183981033 6225265 1236981..1237451 1 NC_010612.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 1237451 rpsG 6225265 rpsG Mycobacterium marinum M 30S ribosomal protein S7 YP_001849324.1 1236981 D 216594 CDS YP_001849325.1 183981034 6225266 1237532..1239637 1 NC_010612.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 1239637 fusA1 6225266 fusA1 Mycobacterium marinum M elongation factor G YP_001849325.1 1237532 D 216594 CDS YP_001849326.1 183981035 6225267 1239824..1241014 1 NC_010612.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1241014 tuf 6225267 tuf Mycobacterium marinum M elongation factor Tu YP_001849326.1 1239824 D 216594 CDS YP_001849327.1 183981036 6225268 1241264..1242073 1 NC_010612.1 hypothetical protein 1242073 6225268 MMAR_1015 Mycobacterium marinum M hypothetical protein YP_001849327.1 1241264 D 216594 CDS YP_001849328.1 183981037 6225269 1242207..1243034 1 NC_010612.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1243034 6225269 MMAR_1016 Mycobacterium marinum M 3-ketoacyl-ACP reductase YP_001849328.1 1242207 D 216594 CDS YP_001849329.1 183981038 6225270 1243044..1244282 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin reductase 1244282 6225270 MMAR_1017 Mycobacterium marinum M ferredoxin reductase YP_001849329.1 1243044 D 216594 CDS YP_001849330.1 183981039 6225271 complement(1244381..1245442) 1 NC_010612.1 hypothetical protein 1245442 6225271 MMAR_1018 Mycobacterium marinum M hypothetical protein YP_001849330.1 1244381 R 216594 CDS YP_001849331.1 183981040 6225272 complement(1245442..1246035) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulator 1246035 6225272 MMAR_1019 Mycobacterium marinum M transcriptional regulator YP_001849331.1 1245442 R 216594 CDS YP_001849332.1 183981041 6225273 1246252..1246563 1 NC_010612.1 hypothetical protein 1246563 6225273 MMAR_1020 Mycobacterium marinum M hypothetical protein YP_001849332.1 1246252 D 216594 CDS YP_001849333.1 183981042 6225274 1246560..1247735 1 NC_010612.1 required for coenzyme pyrrolo-quinoline-quinone (PQQ) biosynthesis; coenzyme PQQ synthesis protein E, PqqE 1247735 pqqE 6225274 pqqE Mycobacterium marinum M coenzyme PQQ synthesis protein E, PqqE YP_001849333.1 1246560 D 216594 CDS YP_001849334.1 183981043 6225275 1247738..1248910 1 NC_010612.1 involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C]; L-lactate dehydrogenase (cytochrome) LldD1 1248910 lldD1 6225275 lldD1 Mycobacterium marinum M L-lactate dehydrogenase (cytochrome) LldD1 YP_001849334.1 1247738 D 216594 CDS YP_001849335.1 183981044 6225276 1249065..1249817 1 NC_010612.1 catalyses the hydrolysis of creatinine to creatine; creatinine amidohydrolase 1249817 6225276 MMAR_1023 Mycobacterium marinum M creatinine amidohydrolase YP_001849335.1 1249065 D 216594 CDS YP_001849336.1 183981045 6225277 1249814..1251226 1 NC_010612.1 membrane glycosyl transferase 1251226 6225277 MMAR_1024 Mycobacterium marinum M membrane glycosyl transferase YP_001849336.1 1249814 D 216594 CDS YP_001849337.1 183981046 6225278 1251235..1252671 1 NC_010612.1 dehydrogenase 1252671 6225278 MMAR_1025 Mycobacterium marinum M dehydrogenase YP_001849337.1 1251235 D 216594 CDS YP_001849338.1 183981047 6225279 complement(1252661..1253296) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 1253296 6225279 MMAR_1026 Mycobacterium marinum M TetR family transcriptional regulator YP_001849338.1 1252661 R 216594 CDS YP_001849339.1 183981048 6225280 complement(1253431..1255416) 1 NC_010612.1 N-term truncated compared to orthologues; PPE family protein 1255416 6225280 MMAR_1027 Mycobacterium marinum M PPE family protein YP_001849339.1 1253431 R 216594 CDS YP_001849340.1 183981049 6225281 1256153..1260349 1 NC_010612.1 PPE family protein 1260349 6225281 MMAR_1028 Mycobacterium marinum M PPE family protein YP_001849340.1 1256153 D 216594 CDS YP_001849341.1 183981050 6225282 1260905..1262236 1 NC_010612.1 lipase 1262236 6225282 MMAR_1029 Mycobacterium marinum M lipase YP_001849341.1 1260905 D 216594 CDS YP_001849342.1 183981051 6225283 1262169..1262489 1 NC_010612.1 hypothetical protein 1262489 6225283 MMAR_5549 Mycobacterium marinum M hypothetical protein YP_001849342.1 1262169 D 216594 CDS YP_001849343.1 183981052 6225284 1262780..1263085 1 NC_010612.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 1263085 rpsJ 6225284 rpsJ Mycobacterium marinum M 30S ribosomal protein S10 YP_001849343.1 1262780 D 216594 CDS YP_001849344.1 183981053 6225285 1263100..1263753 1 NC_010612.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 1263753 rplC 6225285 rplC Mycobacterium marinum M 50S ribosomal protein L3 YP_001849344.1 1263100 D 216594 CDS YP_001849345.1 183981054 6225286 1263753..1264427 1 NC_010612.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 1264427 rplD 6225286 rplD Mycobacterium marinum M 50S ribosomal protein L4 YP_001849345.1 1263753 D 216594 CDS YP_001849346.1 183981055 6225287 1264427..1264729 1 NC_010612.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 1264729 rplW 6225287 rplW Mycobacterium marinum M 50S ribosomal protein L23 YP_001849346.1 1264427 D 216594 CDS YP_001849347.1 183981056 6225288 1264759..1265601 1 NC_010612.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 1265601 rplB 6225288 rplB Mycobacterium marinum M 50S ribosomal protein L2 YP_001849347.1 1264759 D 216594 CDS YP_001849348.1 183981057 6225289 1265623..1265904 1 NC_010612.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 1265904 rpsS 6225289 rpsS Mycobacterium marinum M 30S ribosomal protein S19 YP_001849348.1 1265623 D 216594 CDS YP_001849349.1 183981058 6225290 1265933..1266463 1 NC_010612.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 1266463 rplV 6225290 rplV Mycobacterium marinum M 50S ribosomal protein L22 YP_001849349.1 1265933 D 216594 CDS YP_001849350.1 183981059 6225291 1266463..1267290 1 NC_010612.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 1267290 rpsC 6225291 rpsC Mycobacterium marinum M 30S ribosomal protein S3 YP_001849350.1 1266463 D 216594 CDS YP_001849351.1 183981060 6225292 1267294..1267710 1 NC_010612.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 1267710 rplP 6225292 rplP Mycobacterium marinum M 50S ribosomal protein L16 YP_001849351.1 1267294 D 216594 CDS YP_001849352.1 183981061 6225293 1267710..1267952 1 NC_010612.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 1267952 rpmC 6225293 rpmC Mycobacterium marinum M 50S ribosomal protein L29 YP_001849352.1 1267710 D 216594 CDS YP_001849353.1 183981062 6225294 1267952..1268311 1 NC_010612.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 1268311 rpsQ 6225294 rpsQ Mycobacterium marinum M 30S ribosomal protein S17 YP_001849353.1 1267952 D 216594 CDS YP_001849354.1 183981063 6225295 1268455..1270824 1 NC_010612.1 arylsulfatase AtsA 1270824 atsA 6225295 atsA Mycobacterium marinum M arylsulfatase AtsA YP_001849354.1 1268455 D 216594 CDS YP_001849355.1 183981064 6225296 1270778..1271482 1 NC_010612.1 hypothetical protein 1271482 6225296 MMAR_1042 Mycobacterium marinum M hypothetical protein YP_001849355.1 1270778 D 216594 CDS YP_001849356.1 183981065 6225297 1271487..1272368 1 NC_010612.1 hypothetical protein 1272368 6225297 MMAR_1043 Mycobacterium marinum M hypothetical protein YP_001849356.1 1271487 D 216594 CDS YP_001849357.1 183981066 6225298 1272498..1273436 1 NC_010612.1 transmembrane protein 1273436 6225298 MMAR_1044 Mycobacterium marinum M transmembrane protein YP_001849357.1 1272498 D 216594 CDS YP_001849358.1 183981067 6225299 1273687..1274055 1 NC_010612.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 1274055 rplN 6225299 rplN Mycobacterium marinum M 50S ribosomal protein L14 YP_001849358.1 1273687 D 216594 CDS YP_001849359.1 183981068 6225300 1274056..1274379 1 NC_010612.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 1274379 rplX 6225300 rplX Mycobacterium marinum M 50S ribosomal protein L24 YP_001849359.1 1274056 D 216594 CDS YP_001849360.1 183981069 6225301 1274376..1274948 1 NC_010612.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 1274948 rplE 6225301 rplE Mycobacterium marinum M 50S ribosomal protein L5 YP_001849360.1 1274376 D 216594 CDS YP_001849361.1 183981070 6225302 1274953..1275138 1 NC_010612.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 1275138 rpsN 6225302 rpsN Mycobacterium marinum M 30S ribosomal protein S14 YP_001849361.1 1274953 D 216594 CDS YP_001849362.1 183981071 6225303 1275215..1275613 1 NC_010612.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 1275613 rpsH 6225303 rpsH Mycobacterium marinum M 30S ribosomal protein S8 YP_001849362.1 1275215 D 216594 CDS YP_001849363.1 183981072 6225304 1275624..1276163 1 NC_010612.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 1276163 rplF 6225304 rplF Mycobacterium marinum M 50S ribosomal protein L6 YP_001849363.1 1275624 D 216594 CDS YP_001849364.1 183981073 6225305 1276166..1276573 1 NC_010612.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 1276573 rplR 6225305 rplR Mycobacterium marinum M 50S ribosomal protein L18 YP_001849364.1 1276166 D 216594 CDS YP_001849365.1 183981074 6225306 1276611..1277285 1 NC_010612.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 1277285 rpsE 6225306 rpsE Mycobacterium marinum M 30S ribosomal protein S5 YP_001849365.1 1276611 D 216594 CDS YP_001849366.1 183981075 6225307 1277282..1277500 1 NC_010612.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 1277500 rpmD 6225307 rpmD Mycobacterium marinum M 50S ribosomal protein L30 YP_001849366.1 1277282 D 216594 CDS YP_001849367.1 183981076 6225308 1277497..1277937 1 NC_010612.1 late assembly protein; 50S ribosomal protein L15 1277937 rplO 6225308 rplO Mycobacterium marinum M 50S ribosomal protein L15 YP_001849367.1 1277497 D 216594 CDS YP_001849368.1 183981077 6225309 complement(1278005..1278931) 1 NC_010612.1 flavin-dependent oxidoreductase 1278931 6225309 MMAR_1055 Mycobacterium marinum M flavin-dependent oxidoreductase YP_001849368.1 1278005 R 216594 CDS YP_001849369.1 183981078 6225310 1279018..1280820 1 NC_010612.1 involved in digestion of the cleaved signal peptides. this activity is necessary to maintain proper secretion of mature proteins across the membrane; protease IV, Ssp 1280820 ssp 6225310 ssp Mycobacterium marinum M protease IV, Ssp YP_001849369.1 1279018 D 216594 CDS YP_001849370.1 183981079 6225311 complement(1280817..1281731) 1 NC_010612.1 O-methyltransferase 1281731 6225311 MMAR_1057 Mycobacterium marinum M O-methyltransferase YP_001849370.1 1280817 R 216594 CDS YP_001849371.1 183981080 6225312 complement(1281751..1282653) 1 NC_010612.1 O-methyltransferase 1282653 6225312 MMAR_1058 Mycobacterium marinum M O-methyltransferase YP_001849371.1 1281751 R 216594 CDS YP_001849372.1 183981081 6225313 complement(1282650..1283624) 1 NC_010612.1 O-methyltransferase 1283624 6225313 MMAR_1059 Mycobacterium marinum M O-methyltransferase YP_001849372.1 1282650 R 216594 CDS YP_001849373.1 183981082 6225315 complement(1285864..1286544) 1 NC_010612.1 methyltransferase 1286544 6225315 MMAR_1062 Mycobacterium marinum M methyltransferase YP_001849373.1 1285864 R 216594 CDS YP_001849374.1 183981083 6225316 1286618..1287478 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 1287478 6225316 MMAR_1063 Mycobacterium marinum M transcriptional regulatory protein YP_001849374.1 1286618 D 216594 CDS YP_001849375.1 183981084 6225317 complement(1287502..1288158) 1 NC_010612.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 1288158 fucA 6225317 fucA Mycobacterium marinum M L-fuculose phosphate aldolase YP_001849375.1 1287502 R 216594 CDS YP_001849376.1 183981085 6225318 complement(1288155..1289144) 1 NC_010612.1 involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis. catalyzes the oxidation of D-3-phosphoglycerate to 3- phosphohydroxypyruvate [catalytic activity: 3- phosphoglycerate + NAD(+) = 3-phosphohydroxypyruvate + NADH]; D-3-phosphoglycerate dehydrogenase 1289144 serA2 6225318 serA2 Mycobacterium marinum M D-3-phosphoglycerate dehydrogenase YP_001849376.1 1288155 R 216594 CDS YP_001849377.1 183981086 6225319 1289175..1290533 1 NC_010612.1 phosphorylates D-xylulose [catalytic activity: ATP + D-xylulose = ADP + D-xylulose 5-phosphate]; D-xylulose-kinase (xylulokinase), XylB 1290533 xylB 6225319 xylB Mycobacterium marinum M D-xylulose-kinase (xylulokinase), XylB YP_001849377.1 1289175 D 216594 CDS YP_001849378.1 183981087 6225320 1290681..1291346 1 NC_010612.1 hypothetical protein 1291346 6225320 MMAR_1067 Mycobacterium marinum M hypothetical protein YP_001849378.1 1290681 D 216594 CDS YP_001849379.1 183981088 6225321 complement(1291397..1292305) 1 NC_010612.1 O-methyltransferase 1292305 6225321 MMAR_1068 Mycobacterium marinum M O-methyltransferase YP_001849379.1 1291397 R 216594 CDS YP_001849380.1 183981089 6225322 complement(1292322..1293272) 1 NC_010612.1 O-methyltransferase 1293272 6225322 MMAR_1069 Mycobacterium marinum M O-methyltransferase YP_001849380.1 1292322 R 216594 CDS YP_001849381.1 183981090 6225323 1293539..1294864 1 NC_010612.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 1294864 secY 6225323 secY Mycobacterium marinum M preprotein translocase subunit SecY YP_001849381.1 1293539 D 216594 CDS YP_001849382.1 183981091 6225324 1294861..1295406 1 NC_010612.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 1295406 adk 6225324 adk Mycobacterium marinum M adenylate kinase YP_001849382.1 1294861 D 216594 CDS YP_001849383.1 183981092 6225325 1295409..1296209 1 NC_010612.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 1296209 mapA 6225325 mapA Mycobacterium marinum M methionine aminopeptidase YP_001849383.1 1295409 D 216594 CDS YP_001849384.1 183981093 6225326 1296262..1296795 1 NC_010612.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and secreted or membrane proteins; RNA polymerase sigma factor SigL 1296795 sigL 6225326 sigL Mycobacterium marinum M RNA polymerase sigma factor SigL YP_001849384.1 1296262 D 216594 CDS YP_001849385.1 183981094 6225327 1296874..1297620 1 NC_010612.1 function unknown, domain identity suggests possible role in transcription regulation; hypothetical protein 1297620 6225327 MMAR_1074 Mycobacterium marinum M hypothetical protein YP_001849385.1 1296874 D 216594 CDS YP_001849386.1 183981095 6225328 1297707..1298207 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulator 1298207 6225328 MMAR_1075 Mycobacterium marinum M transcriptional regulator YP_001849386.1 1297707 D 216594 CDS YP_001849387.1 183981096 6225329 1298231..1298779 1 NC_010612.1 hypothetical protein 1298779 6225329 MMAR_1076 Mycobacterium marinum M hypothetical protein YP_001849387.1 1298231 D 216594 CDS YP_001849388.1 183981097 6225330 complement(1298792..1299676) 1 NC_010612.1 catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate [catalytic activity: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3- oxopropanoate + NADH]; 3-hydroxyisobutyrate dehydrogenase 1299676 mmsB 6225330 mmsB Mycobacterium marinum M 3-hydroxyisobutyrate dehydrogenase YP_001849388.1 1298792 R 216594 CDS YP_001849389.1 183981098 6225331 complement(1299689..1300861) 1 NC_010612.1 lipid metabolism; acyl-CoA dehydrogenase, FadE9 1300861 fadE9 6225331 fadE9 Mycobacterium marinum M acyl-CoA dehydrogenase, FadE9 YP_001849389.1 1299689 R 216594 CDS YP_001849390.1 183981099 6225332 complement(1300867..1302387) 1 NC_010612.1 plays a role in valine and pyrimidine metabolism. binds fatty acyl-CoA [catalytic activity: 2-methyl-3- oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH]; methylmalonate semialdehyde dehydrogenase, MmsA 1302387 mmsA 6225332 mmsA Mycobacterium marinum M methylmalonate semialdehyde dehydrogenase, MmsA YP_001849390.1 1300867 R 216594 CDS YP_001849391.1 183981100 6225333 complement(1302567..1304129) 1 NC_010612.1 transmembrane carbohydrate transport protein 1304129 6225333 MMAR_1080 Mycobacterium marinum M transmembrane carbohydrate transport protein YP_001849391.1 1302567 R 216594 CDS YP_001849392.1 183981101 6225334 complement(1304293..1304898) 1 NC_010612.1 involved in dTDP-L-rhamnose biosynthesis, within the O antigen biosynthesis pathway of lipopolysaccharide biosynthesis: conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-4-keto-rhamnose [catalytic activity: DTDP-4- dehydro-6-deoxy-D-glucose = DTDP-4-dehydro-6-deoxy-L- mannose]; dTDP-4-dehydrorhamnose 3,5-epimerase, RmlC 1304898 rmlC 6225334 rmlC Mycobacterium marinum M dTDP-4-dehydrorhamnose 3,5-epimerase, RmlC YP_001849392.1 1304293 R 216594 CDS YP_001849393.1 183981102 6225335 complement(1304900..1305895) 1 NC_010612.1 involved in dTDP-L-rhamnose biosynthesis [catalytic activity: dTDP-glucose = DTDP-4-dehydro-6-deoxy-D-glucose + H(2)O]; dTDP-glucose-4,6-dehydratase, RmlB 1305895 rmlB 6225335 rmlB Mycobacterium marinum M dTDP-glucose-4,6-dehydratase, RmlB YP_001849393.1 1304900 R 216594 CDS YP_001849394.1 183981103 6225336 complement(1305905..1306765) 1 NC_010612.1 hypothetical protein 1306765 6225336 MMAR_1083 Mycobacterium marinum M hypothetical protein YP_001849394.1 1305905 R 216594 CDS YP_001849395.1 183981104 6225337 complement(1306792..1307688) 1 NC_010612.1 hypothetical protein 1307688 6225337 MMAR_1084 Mycobacterium marinum M hypothetical protein YP_001849395.1 1306792 R 216594 CDS YP_001849396.1 183981105 6225338 1307936..1308157 1 NC_010612.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1308157 infA 6225338 infA Mycobacterium marinum M translation initiation factor IF-1 YP_001849396.1 1307936 D 216594 CDS YP_001849397.1 183981106 6225339 1308191..1308304 1 NC_010612.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 1308304 rpmJ 6225339 rpmJ Mycobacterium marinum M 50S ribosomal protein L36 YP_001849397.1 1308191 D 216594 CDS YP_001849398.1 183981107 6225340 1308495..1308869 1 NC_010612.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 1308869 rpsM 6225340 rpsM Mycobacterium marinum M 30S ribosomal protein S13 YP_001849398.1 1308495 D 216594 CDS YP_001849399.1 183981108 6225341 1308873..1309289 1 NC_010612.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 1309289 rpsK 6225341 rpsK Mycobacterium marinum M 30S ribosomal protein S11 YP_001849399.1 1308873 D 216594 CDS YP_001849400.1 183981109 6225342 1309308..1309913 1 NC_010612.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 1309913 rpsD 6225342 rpsD Mycobacterium marinum M 30S ribosomal protein S4 YP_001849400.1 1309308 D 216594 CDS YP_001849401.1 183981110 6225343 1309999..1311042 1 NC_010612.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 1311042 rpoA 6225343 rpoA Mycobacterium marinum M DNA-directed RNA polymerase subunit alpha YP_001849401.1 1309999 D 216594 CDS YP_001849402.1 183981111 6225344 1311103..1311672 1 NC_010612.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 1311672 rplQ 6225344 rplQ Mycobacterium marinum M 50S ribosomal protein L17 YP_001849402.1 1311103 D 216594 CDS YP_001849403.1 183981112 6225345 1311803..1312516 1 NC_010612.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1312516 truA 6225345 truA Mycobacterium marinum M tRNA pseudouridine synthase A YP_001849403.1 1311803 D 216594 CDS YP_001849404.1 183981113 6225346 complement(1312532..1314007) 1 NC_010612.1 permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-serine/D-alanine/glycine transporter, CycA 1314007 cycA 6225346 cycA Mycobacterium marinum M D-serine/D-alanine/glycine transporter, CycA YP_001849404.1 1312532 R 216594 CDS YP_001849405.1 183981114 6225347 complement(1314278..1315420) 1 NC_010612.1 PPE family protein 1315420 6225347 MMAR_1094 Mycobacterium marinum M PPE family protein YP_001849405.1 1314278 R 216594 CDS YP_001849406.1 183981115 6225348 complement(1315487..1316683) 1 NC_010612.1 PPE family protein 1316683 6225348 MMAR_1095 Mycobacterium marinum M PPE family protein YP_001849406.1 1315487 R 216594 CDS YP_001849407.1 183981116 6225349 complement(1316812..1318470) 1 NC_010612.1 similar to other proteins involved in nucleotide transport; hypothetical protein 1318470 6225349 MMAR_1096 Mycobacterium marinum M hypothetical protein YP_001849407.1 1316812 R 216594 CDS YP_001849408.1 183981117 6225350 complement(1318730..1319425) 1 NC_010612.1 hydrolysis of cutin (a polyester that forms the structure of plant cuticle); cutinase 1319425 cut4 6225350 cut4 Mycobacterium marinum M cutinase YP_001849408.1 1318730 R 216594 CDS YP_001849409.1 183981118 6225351 complement(1319457..1320260) 1 NC_010612.1 cutinase 1320260 cut3 6225351 cut3 Mycobacterium marinum M cutinase YP_001849409.1 1319457 R 216594 CDS YP_001849410.1 183981119 6225352 1320373..1321881 1 NC_010612.1 hypothetical protein 1321881 6225352 MMAR_1099 Mycobacterium marinum M hypothetical protein YP_001849410.1 1320373 D 216594 CDS YP_001849411.1 183981120 6225353 complement(1321771..1323144) 1 NC_010612.1 membrane-anchored serine protease (mycosin), MycP4 1323144 mycP4 6225353 mycP4 Mycobacterium marinum M membrane-anchored serine protease (mycosin), MycP4 YP_001849411.1 1321771 R 216594 CDS YP_001849412.1 183981121 6225354 complement(1323141..1324523) 1 NC_010612.1 hypothetical protein 1324523 6225354 MMAR_1101 Mycobacterium marinum M hypothetical protein YP_001849412.1 1323141 R 216594 CDS YP_001849413.1 183981122 6225355 1324638..1328318 1 NC_010612.1 function unknown but has 3 ATP binding P-loop motifs; hypothetical protein 1328318 6225355 MMAR_1102 Mycobacterium marinum M hypothetical protein YP_001849413.1 1324638 D 216594 CDS YP_001849414.1 183981123 6225356 1328315..1329559 1 NC_010612.1 hypothetical protein 1329559 6225356 MMAR_1103 Mycobacterium marinum M hypothetical protein YP_001849414.1 1328315 D 216594 CDS YP_001849415.1 183981124 6225357 1329622..1329975 1 NC_010612.1 EsaT-6 like protein, EsxU 1329975 esxU 6225357 esxU Mycobacterium marinum M EsaT-6 like protein, EsxU YP_001849415.1 1329622 D 216594 CDS YP_001849416.1 183981125 6225358 1329991..1330287 1 NC_010612.1 EsaT-6 like protein, EsxT 1330287 esxT 6225358 esxT Mycobacterium marinum M EsaT-6 like protein, EsxT YP_001849416.1 1329991 D 216594 CDS YP_001849417.1 183981126 6225359 1330526..1330969 1 NC_010612.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 1330969 rplM 6225359 rplM Mycobacterium marinum M 50S ribosomal protein L13 YP_001849417.1 1330526 D 216594 CDS YP_001849418.1 183981127 6225360 1330966..1331424 1 NC_010612.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 1331424 rpsI 6225360 rpsI Mycobacterium marinum M 30S ribosomal protein S9 YP_001849418.1 1330966 D 216594 CDS YP_001849419.1 183981128 6225361 1331575..1332912 1 NC_010612.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1332912 glmM 6225361 glmM Mycobacterium marinum M phosphoglucosamine mutase YP_001849419.1 1331575 D 216594 CDS YP_001849420.1 183981129 6225362 1333017..1333328 1 NC_010612.1 hypothetical protein 1333328 6225362 MMAR_1109 Mycobacterium marinum M hypothetical protein YP_001849420.1 1333017 D 216594 CDS YP_001849421.1 183981130 6225363 1333331..1334728 1 NC_010612.1 hypothetical protein 1334728 6225363 MMAR_1110 Mycobacterium marinum M hypothetical protein YP_001849421.1 1333331 D 216594 CDS YP_001849422.1 183981131 6225364 complement(1334755..1335798) 1 NC_010612.1 function unknown but domain identity with flavin- dependent oxidoreductases; coenzyme F420-dependent oxidoreductase 1335798 6225364 MMAR_1111 Mycobacterium marinum M coenzyme F420-dependent oxidoreductase YP_001849422.1 1334755 R 216594 CDS YP_001849423.1 183981132 6225365 complement(1335814..1336653) 1 NC_010612.1 hydrolase domain identity; hypothetical protein 1336653 6225365 MMAR_1112 Mycobacterium marinum M hypothetical protein YP_001849423.1 1335814 R 216594 CDS YP_001849424.1 183981133 6225366 complement(1336663..1337133) 1 NC_010612.1 hypothetical protein 1337133 6225366 MMAR_1113 Mycobacterium marinum M hypothetical protein YP_001849424.1 1336663 R 216594 CDS YP_001849425.1 183981134 6225367 1337246..1339123 1 NC_010612.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 1339123 glmS 6225367 glmS Mycobacterium marinum M glucosamine--fructose-6-phosphate aminotransferase YP_001849425.1 1337246 D 216594 CDS YP_001849426.1 183981135 6225368 1339188..1340030 1 NC_010612.1 hypothetical protein 1340030 6225368 MMAR_1115 Mycobacterium marinum M hypothetical protein YP_001849426.1 1339188 D 216594 CDS YP_001849427.1 183981136 6225369 1340082..1340795 1 NC_010612.1 hypothetical protein 1340795 6225369 MMAR_1116 Mycobacterium marinum M hypothetical protein YP_001849427.1 1340082 D 216594 CDS YP_001849428.1 183981137 6225370 1340814..1342247 1 NC_010612.1 has domain identity with YjeF-related protein N- terminus and sugar kinases c-terminus; transmembrane protein 1342247 6225370 MMAR_1117 Mycobacterium marinum M transmembrane protein YP_001849428.1 1340814 D 216594 CDS YP_001849429.1 183981138 6225371 1342284..1343669 1 NC_010612.1 catalyzes the production of GabA [catalytic activity: L-glutamate = 4-aminobutanoate + CO(2)]; glutamate decarboxylase 1343669 gadB 6225371 gadB Mycobacterium marinum M glutamate decarboxylase YP_001849429.1 1342284 D 216594 CDS YP_001849430.1 183981139 6225372 1343756..1344922 1 NC_010612.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 1344922 alr 6225372 alr Mycobacterium marinum M alanine racemase YP_001849430.1 1343756 D 216594 CDS YP_001849431.1 183981140 6225373 1344912..1346033 1 NC_010612.1 hydrolase 1346033 6225373 MMAR_1120 Mycobacterium marinum M hydrolase YP_001849431.1 1344912 D 216594 CDS YP_001849432.1 183981141 6225374 1346026..1346496 1 NC_010612.1 ATPase domain; hypothetical protein 1346496 6225374 MMAR_1121 Mycobacterium marinum M hypothetical protein YP_001849432.1 1346026 D 216594 CDS YP_001849433.1 183981142 6225375 1346493..1347119 1 NC_010612.1 peptidase; hypothetical protein 1347119 6225375 MMAR_1122 Mycobacterium marinum M hypothetical protein YP_001849433.1 1346493 D 216594 CDS YP_001849434.1 183981143 6225376 1347116..1347592 1 NC_010612.1 this enzyme acetylates the N-terminal alanine of ribosomal protein S18 [catalytic activity: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N- acetyl-L-alanine]; ribosomal-protein-alanine acetyltransferase, RimI 1347592 rimI 6225376 rimI Mycobacterium marinum M ribosomal-protein-alanine acetyltransferase, RimI YP_001849434.1 1347116 D 216594 CDS YP_001849435.1 183981144 6225377 1347593..1348624 1 NC_010612.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 1348624 gcp 6225377 gcp Mycobacterium marinum M putative DNA-binding/iron metalloprotein/AP endonuclease YP_001849435.1 1347593 D 216594 CDS YP_001849436.1 183981145 6225378 1348938..1349240 1 NC_010612.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1349240 groES 6225378 groES Mycobacterium marinum M co-chaperonin GroES YP_001849436.1 1348938 D 216594 CDS YP_001849437.1 183981146 6225379 1349333..1350952 1 NC_010612.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; chaperonin GroEL 1350952 groEL 6225379 groEL Mycobacterium marinum M chaperonin GroEL YP_001849437.1 1349333 D 216594 CDS YP_001849438.1 183981147 6225380 1351203..1352423 1 NC_010612.1 possible transcriptional regulator; hypothetical protein 1352423 6225380 MMAR_1127 Mycobacterium marinum M hypothetical protein YP_001849438.1 1351203 D 216594 CDS YP_001849439.1 183981148 6225381 complement(1352460..1352897) 1 NC_010612.1 hypothetical protein 1352897 6225381 MMAR_1128 Mycobacterium marinum M hypothetical protein YP_001849439.1 1352460 R 216594 CDS YP_001849440.1 183981149 6225382 complement(1353163..1354878) 1 NC_010612.1 PPE family protein 1354878 6225382 MMAR_1129 Mycobacterium marinum M PPE family protein YP_001849440.1 1353163 R 216594 CDS YP_001849441.1 183981150 6225383 1354964..1355446 1 NC_010612.1 N-term truncation of 14 aa compared to M. ulcerans (frame shift mutation); hypothetical protein 1355446 6225383 MMAR_5550 Mycobacterium marinum M hypothetical protein YP_001849441.1 1354964 D 216594 CDS YP_001849442.1 183981151 6225384 complement(1355427..1357121) 1 NC_010612.1 PPE family protein 1357121 6225384 MMAR_1130 Mycobacterium marinum M PPE family protein YP_001849442.1 1355427 R 216594 CDS YP_001849443.1 183981152 6225385 1357453..1359108 1 NC_010612.1 metal-dependent hydrolase 1359108 6225385 MMAR_1131 Mycobacterium marinum M metal-dependent hydrolase YP_001849443.1 1357453 D 216594 CDS YP_001849444.1 183981153 6225386 complement(1359154..1359462) 1 NC_010612.1 intracellular redox sensor that integrates environmental redox signals with core intermediary metabolism; WhiB-like regulatory protein, WhiB3 1359462 whiB3 6225386 whiB3 Mycobacterium marinum M WhiB-like regulatory protein, WhiB3 YP_001849444.1 1359154 R 216594 CDS YP_001849445.1 183981154 6225387 1360001..1360873 1 NC_010612.1 hypothetical protein 1360873 6225387 MMAR_1133 Mycobacterium marinum M hypothetical protein YP_001849445.1 1360001 D 216594 CDS YP_001849446.1 183981155 6225388 1360949..1361542 1 NC_010612.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase; RNA polymerase sigma factor SigD 1361542 sigD 6225388 sigD Mycobacterium marinum M RNA polymerase sigma factor SigD YP_001849446.1 1360949 D 216594 CDS YP_001849447.1 183981156 6225389 1361535..1362479 1 NC_010612.1 hypothetical protein 1362479 6225389 MMAR_1135 Mycobacterium marinum M hypothetical protein YP_001849447.1 1361535 D 216594 CDS YP_001849448.1 183981157 6225390 complement(1362643..1363056) 1 NC_010612.1 hypothetical protein 1363056 6225390 MMAR_1136 Mycobacterium marinum M hypothetical protein YP_001849448.1 1362643 R 216594 CDS YP_001849449.1 183981158 6225391 1363220..1364818 1 NC_010612.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 1364818 guaB2 6225391 guaB2 Mycobacterium marinum M inosine 5'-monophosphate dehydrogenase YP_001849449.1 1363220 D 216594 CDS YP_001849450.1 183981159 6225392 1364828..1365955 1 NC_010612.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 1365955 guaB3 6225392 guaB3 Mycobacterium marinum M inosine 5-monophosphate dehydrogenase YP_001849450.1 1364828 D 216594 CDS YP_001849451.1 183981160 6225393 1366136..1367962 1 NC_010612.1 PPE family protein 1367962 6225393 MMAR_1139 Mycobacterium marinum M PPE family protein YP_001849451.1 1366136 D 216594 CDS YP_001849452.1 183981161 6225394 1368051..1369796 1 NC_010612.1 involved in cholesterol metabolism [catalytic activity: cholesterol + O(2) = cholest-4-en-3-one + H(2)O(2)]; cholesterol oxidase ChoD 1369796 choD 6225394 choD Mycobacterium marinum M cholesterol oxidase ChoD YP_001849452.1 1368051 D 216594 CDS YP_001849453.1 183981162 6225395 complement(1369822..1370718) 1 NC_010612.1 in E. coli this enzyme catalyses the oxygenolytic release of sulfite from taurine; taurine catabolism dioxygenase, TauD 1370718 tauD 6225395 tauD Mycobacterium marinum M taurine catabolism dioxygenase, TauD YP_001849453.1 1369822 R 216594 CDS YP_001849454.1 183981163 6225396 1370845..1371354 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulator 1371354 6225396 MMAR_1142 Mycobacterium marinum M transcriptional regulator YP_001849454.1 1370845 D 216594 CDS YP_001849455.1 183981164 6225397 complement(1371340..1373724) 1 NC_010612.1 similar to maltose phosphorylase, a dimeric enzyme that catalyses the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucose; glycosyl hydrolase 1373724 6225397 MMAR_1143 Mycobacterium marinum M glycosyl hydrolase YP_001849455.1 1371340 R 216594 CDS YP_001849456.1 183981165 6225398 complement(1373721..1374461) 1 NC_010612.1 cellular metabolism; hydrolase 1374461 6225398 MMAR_1144 Mycobacterium marinum M hydrolase YP_001849456.1 1373721 R 216594 CDS YP_001849457.1 183981166 6225399 1374543..1375061 1 NC_010612.1 hypothetical protein 1375061 6225399 MMAR_5486 Mycobacterium marinum M hypothetical protein YP_001849457.1 1374543 D 216594 CDS YP_001849458.1 183981167 6225400 1375100..1375717 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 1375717 6225400 MMAR_1145 Mycobacterium marinum M transcriptional regulatory protein YP_001849458.1 1375100 D 216594 CDS YP_001849459.1 183981168 6225401 complement(1375714..1377270) 1 NC_010612.1 integral membrane transport protein 1377270 6225401 MMAR_1146 Mycobacterium marinum M integral membrane transport protein YP_001849459.1 1375714 R 216594 CDS YP_001849460.1 183981169 6225402 1377349..1378032 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 1378032 6225402 MMAR_1147 Mycobacterium marinum M transcriptional regulatory protein YP_001849460.1 1377349 D 216594 CDS YP_001849461.1 183981170 6225403 1378111..1379688 1 NC_010612.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1379688 guaA 6225403 guaA Mycobacterium marinum M GMP synthase YP_001849461.1 1378111 D 216594 CDS YP_001849462.1 183981171 6225404 complement(1379744..1380433) 1 NC_010612.1 hypothetical protein 1380433 6225404 MMAR_1149 Mycobacterium marinum M hypothetical protein YP_001849462.1 1379744 R 216594 CDS YP_001849463.1 183981172 6225405 1380541..1381200 1 NC_010612.1 hypothetical protein 1381200 6225405 MMAR_1150 Mycobacterium marinum M hypothetical protein YP_001849463.1 1380541 D 216594 CDS YP_001849464.1 183981173 6225406 1381207..1382778 1 NC_010612.1 function unknown but belongs to the DNA/RNA polymerase superfamily; hypothetical protein 1382778 6225406 MMAR_1151 Mycobacterium marinum M hypothetical protein YP_001849464.1 1381207 D 216594 CDS YP_001849465.1 183981174 6225407 complement(1382851..1383801) 1 NC_010612.1 involved in purine salvage. catalyzes the hydrolysis of all of the commonly occurring purine and pyrimidine nucleosides into ribose and the associated base, and could have a preference for inosine and uridine as substrates [catalytic activity: a N-D-ribosylpurine + H(2)O = a purine + d- ribose]; inosine-uridine nucleoside hydrolase, IunH 1383801 iunH 6225407 iunH Mycobacterium marinum M inosine-uridine nucleoside hydrolase, IunH YP_001849465.1 1382851 R 216594 CDS YP_001849466.1 183981175 6225408 complement(1383846..1385858) 1 NC_010612.1 multifunctional protein with fatty acyl-CoA reductase activity in C-terminal part; short chain dehydrogenase 1385858 acrA1 6225408 acrA1 Mycobacterium marinum M short chain dehydrogenase YP_001849466.1 1383846 R 216594 CDS YP_001849467.1 183981176 6225409 complement(1385898..1386596) 1 NC_010612.1 lipoprotein LpqD 1386596 lpqD 6225409 lpqD Mycobacterium marinum M lipoprotein LpqD YP_001849467.1 1385898 R 216594 CDS YP_001849468.1 183981177 6225410 1386707..1387579 1 NC_010612.1 may have dehydratase activity; contains a MaoC protein family domain; hypothetical protein 1387579 6225410 MMAR_1155 Mycobacterium marinum M hypothetical protein YP_001849468.1 1386707 D 216594 CDS YP_001849469.1 183981178 6225411 complement(1387593..1388765) 1 NC_010612.1 involved in osmoregulatory trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [catalytic activity: trehalose 6-phosphate + H(2)O = trehalose + orthophosphate]; trehalose-6-phosphate phosphatase OtsB2 1388765 otsB2 6225411 otsB2 Mycobacterium marinum M trehalose-6-phosphate phosphatase OtsB2 YP_001849469.1 1387593 R 216594 CDS YP_001849470.1 183981179 6225412 complement(1388817..1390151) 1 NC_010612.1 hypothetical protein 1390151 6225412 MMAR_1157 Mycobacterium marinum M hypothetical protein YP_001849470.1 1388817 R 216594 CDS YP_001849471.1 183981180 6225413 1390349..1393651 1 NC_010612.1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.; error-prone DNA polymerase 1393651 dnaE2 6225413 dnaE2 Mycobacterium marinum M error-prone DNA polymerase YP_001849471.1 1390349 D 216594 CDS YP_001849472.1 183981181 6225414 complement(1393727..1394137) 1 NC_010612.1 hypothetical protein 1394137 6225414 MMAR_1159 Mycobacterium marinum M hypothetical protein YP_001849472.1 1393727 R 216594 CDS YP_001849473.1 183981182 6225415 1394170..1394814 1 NC_010612.1 function unknown, probably involved in cellular metabolism; nitroreductase 1394814 6225415 MMAR_1160 Mycobacterium marinum M nitroreductase YP_001849473.1 1394170 D 216594 CDS YP_001849474.1 183981183 6225416 complement(1394826..1396610) 1 NC_010612.1 PE-PGRS family protein 1396610 6225416 MMAR_1161 Mycobacterium marinum M PE-PGRS family protein YP_001849474.1 1394826 R 216594 CDS YP_001849475.1 183981184 6225417 complement(1396735..1398516) 1 NC_010612.1 PE-PGRS family protein 1398516 6225417 MMAR_1162 Mycobacterium marinum M PE-PGRS family protein YP_001849475.1 1396735 R 216594 CDS YP_001849476.1 183981185 6225418 complement(1398697..1399161) 1 NC_010612.1 involved in rRNA methylation; tRNA/rRNA methyltransferase SpoU 1399161 spoU 6225418 spoU Mycobacterium marinum M tRNA/rRNA methyltransferase SpoU YP_001849476.1 1398697 R 216594 CDS YP_001849477.1 183981186 6225419 1399229..1399834 1 NC_010612.1 function unknown but may be involved in RNA methylation; methyltransferase 1399834 6225419 MMAR_1164 Mycobacterium marinum M methyltransferase YP_001849477.1 1399229 D 216594 CDS YP_001849478.1 183981187 6225420 1400051..1402786 1 NC_010612.1 function unknown but may be a regulatory protein as it contains a signal transduction histidine kinase domain; putative regultory protein 1402786 6225420 MMAR_1165 Mycobacterium marinum M putative regultory protein YP_001849478.1 1400051 D 216594 CDS YP_001849479.1 183981188 6225421 1402783..1403214 1 NC_010612.1 hypothetical protein 1403214 6225421 MMAR_1166 Mycobacterium marinum M hypothetical protein YP_001849479.1 1402783 D 216594 CDS YP_001849480.1 183981189 6225422 1403190..1403576 1 NC_010612.1 hypothetical protein 1403576 6225422 MMAR_1167 Mycobacterium marinum M hypothetical protein YP_001849480.1 1403190 D 216594 CDS YP_001849481.1 183981190 6225423 1403557..1404159 1 NC_010612.1 GTP/ATP-binding protein 1404159 6225423 MMAR_1168 Mycobacterium marinum M GTP/ATP-binding protein YP_001849481.1 1403557 D 216594 CDS YP_001849482.1 183981191 6225424 1404168..1404716 1 NC_010612.1 hypothetical protein 1404716 6225424 MMAR_1169 Mycobacterium marinum M hypothetical protein YP_001849482.1 1404168 D 216594 CDS YP_001849483.1 183981192 6225425 1405360..1407351 1 NC_010612.1 function unknown, but involved in lipid degradation; fatty-acid-CoA ligase FadD29 1407351 fadD29_1 6225425 fadD29_1 Mycobacterium marinum M fatty-acid-CoA ligase FadD29 YP_001849483.1 1405360 D 216594 CDS YP_001849484.1 183981193 6225426 1407389..1409836 1 NC_010612.1 could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase 1409836 bioF2_5 6225426 bioF2_5 Mycobacterium marinum M 8-amino-7-oxononanoate synthase YP_001849484.1 1407389 D 216594 CDS YP_001849485.1 183981194 6225427 1409841..1411142 1 NC_010612.1 function unknown, probably involved in cellular metabolism; dehydrogenase 1411142 6225427 MMAR_1172 Mycobacterium marinum M dehydrogenase YP_001849485.1 1409841 D 216594 CDS YP_001849486.1 183981195 6225428 complement(1411186..1413711) 1 NC_010612.1 thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 1413711 6225428 MMAR_1173 Mycobacterium marinum M transmembrane ABC transporter ATP-binding protein YP_001849486.1 1411186 R 216594 CDS YP_001849487.1 183981196 6225429 complement(1413736..1416357) 1 NC_010612.1 thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 1416357 6225429 MMAR_1174 Mycobacterium marinum M transmembrane ABC transporter ATP-binding protein YP_001849487.1 1413736 R 216594 CDS YP_001849488.1 183981197 6225430 complement(1416734..1417927) 1 NC_010612.1 function unknown; probably involved in cellular metabolism; oxidoreductase 1417927 6225430 MMAR_1175 Mycobacterium marinum M oxidoreductase YP_001849488.1 1416734 R 216594 CDS YP_001849489.1 183981198 6225431 1418035..1418880 1 NC_010612.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 1418880 folD 6225431 folD Mycobacterium marinum M bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_001849489.1 1418035 D 216594 CDS YP_001849490.1 183981199 6225432 1418877..1419170 1 NC_010612.1 hypothetical protein 1419170 6225432 MMAR_1177 Mycobacterium marinum M hypothetical protein YP_001849490.1 1418877 D 216594 CDS YP_001849491.1 183981200 6225433 complement(1419174..1419590) 1 NC_010612.1 hypothetical protein 1419590 6225433 MMAR_1178 Mycobacterium marinum M hypothetical protein YP_001849491.1 1419174 R 216594 CDS YP_001849492.1 183981201 6225434 1419844..1421286 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 1421286 6225434 MMAR_1179 Mycobacterium marinum M oxidoreductase YP_001849492.1 1419844 D 216594 CDS YP_001849493.1 183981202 6225435 1421534..1431313 1 NC_010612.1 N-term fused in-frame with fatty acyl-AMP ligase FadD28_1; Synthesis of unknown polyketide; Fatty acyl-AMP ligase FadD28 and polyketide synthase 1431313 6225435 MMAR_1180 Mycobacterium marinum M Fatty acyl-AMP ligase FadD28 and polyketide synthase YP_001849493.1 1421534 D 216594 CDS YP_001849494.1 183981203 6225436 complement(1431353..1431649) 1 NC_010612.1 hypothetical protein 1431649 6225436 MMAR_1181 Mycobacterium marinum M hypothetical protein YP_001849494.1 1431353 R 216594 CDS YP_001849495.1 183981204 6225437 complement(1431711..1432139) 1 NC_010612.1 exported protein 1432139 6225437 MMAR_1182 Mycobacterium marinum M exported protein YP_001849495.1 1431711 R 216594 CDS YP_001849496.1 183981205 6225438 complement(1432198..1432932) 1 NC_010612.1 causes methylation; methyltransferase 1432932 6225438 MMAR_1183 Mycobacterium marinum M methyltransferase YP_001849496.1 1432198 R 216594 CDS YP_001849497.1 183981206 6225439 complement(1432929..1434068) 1 NC_010612.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 1434068 metX 6225439 metX Mycobacterium marinum M homoserine O-acetyltransferase YP_001849497.1 1432929 R 216594 CDS YP_001849498.1 183981207 6225440 complement(1434080..1435429) 1 NC_010612.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase 1435429 metC 6225440 metC Mycobacterium marinum M O-acetylhomoserine aminocarboxypropyltransferase YP_001849498.1 1434080 R 216594 CDS YP_001849499.1 183981208 6225441 1435744..1436970 1 NC_010612.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1436970 icd1 6225441 icd1 Mycobacterium marinum M isocitrate dehydrogenase YP_001849499.1 1435744 D 216594 CDS YP_001849500.1 183981209 6225442 complement(1436981..1437781) 1 NC_010612.1 hypothetical protein 1437781 6225442 MMAR_1187 Mycobacterium marinum M hypothetical protein YP_001849500.1 1436981 R 216594 CDS YP_001849501.1 183981210 6225443 1437939..1438958 1 NC_010612.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 1438958 trpS 6225443 trpS Mycobacterium marinum M tryptophanyl-tRNA synthetase YP_001849501.1 1437939 D 216594 CDS YP_001849502.1 183981211 6225444 1438963..1439991 1 NC_010612.1 integral membrane protein 1439991 6225444 MMAR_1189 Mycobacterium marinum M integral membrane protein YP_001849502.1 1438963 D 216594 CDS YP_001849503.1 183981212 6225445 complement(1439988..1441154) 1 NC_010612.1 involved in N-acetyl glucosamine utilization pathway [catalytic activity: N-acetyl-D-glucosamine 6- phosphate + H(2)O = D-glucosamine 6-phosphate + acetate]; N-acetylglucosamine-6-phosphate deacetylase NagA 1441154 nagA 6225445 nagA Mycobacterium marinum M N-acetylglucosamine-6-phosphate deacetylase NagA YP_001849503.1 1439988 R 216594 CDS YP_001849504.1 183981213 6225446 complement(1441151..1442500) 1 NC_010612.1 thought to be involved in transport of sugar across the membrane. responsible for the translocation of the substrate across the membrane; sugar-transport integral membrane protein SugI 1442500 sugI 6225446 sugI Mycobacterium marinum M sugar-transport integral membrane protein SugI YP_001849504.1 1441151 R 216594 CDS YP_001849505.1 183981214 6225447 complement(1442702..1443949) 1 NC_010612.1 involved in peptidoglycan synthesis (at final stages). hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine]; penicillin-binding protein DacC 1443949 dacC 6225447 dacC Mycobacterium marinum M penicillin-binding protein DacC YP_001849505.1 1442702 R 216594 CDS YP_001849506.1 183981215 6225448 1444116..1444709 1 NC_010612.1 transcriptional regulator 1444709 6225448 MMAR_1193 Mycobacterium marinum M transcriptional regulator YP_001849506.1 1444116 D 216594 CDS YP_001849507.1 183981216 6225449 1444699..1447017 1 NC_010612.1 possible inter-alpha-trypsin inhibitor family heavy chain-related protein-hypothetical secreted or membrane- associated protein containing vWFA domain; hypothetical protein 1447017 6225449 MMAR_1194 Mycobacterium marinum M hypothetical protein YP_001849507.1 1444699 D 216594 CDS YP_001849508.1 183981217 6225450 complement(1447038..1449683) 1 NC_010612.1 PE-PGRS family protein 1449683 6225450 MMAR_1195 Mycobacterium marinum M PE-PGRS family protein YP_001849508.1 1447038 R 216594 CDS YP_001849509.1 183981218 6225451 1449985..1450914 1 NC_010612.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigJ 1450914 sigJ 6225451 sigJ Mycobacterium marinum M RNA polymerase sigma factor SigJ YP_001849509.1 1449985 D 216594 CDS YP_001849510.1 183981219 6225452 complement(1450964..1451563) 1 NC_010612.1 hypothetical protein 1451563 6225452 MMAR_1197 Mycobacterium marinum M hypothetical protein YP_001849510.1 1450964 R 216594 CDS YP_001849511.1 183981220 6225453 1451666..1452109 1 NC_010612.1 hypothetical protein 1452109 6225453 MMAR_1198 Mycobacterium marinum M hypothetical protein YP_001849511.1 1451666 D 216594 CDS YP_001849512.1 183981221 6225454 1452323..1457155 1 NC_010612.1 PE-PGRS family protein 1457155 6225454 MMAR_1199 Mycobacterium marinum M PE-PGRS family protein YP_001849512.1 1452323 D 216594 CDS YP_001849513.1 183981222 6225455 complement(1457167..1457979) 1 NC_010612.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 1457979 sdhB 6225455 sdhB Mycobacterium marinum M succinate dehydrogenase iron-sulfur subunit YP_001849513.1 1457167 R 216594 CDS YP_001849514.1 183981223 6225456 complement(1457979..1459733) 1 NC_010612.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 1459733 sdhA 6225456 sdhA Mycobacterium marinum M succinate dehydrogenase flavoprotein subunit YP_001849514.1 1457979 R 216594 CDS YP_001849515.1 183981224 6225457 complement(1459762..1460229) 1 NC_010612.1 involved in tricarboxylic acid cycle. putative hydrophobic component of the succinate dehydrogenase complex. could be required to anchor the catalytic components to the cytoplasmic membrane; succinate dehydrogenase (hydrophobic membrane anchor subunit) SdhD 1460229 sdhD 6225457 sdhD Mycobacterium marinum M succinate dehydrogenase (hydrophobic membrane anchor subunit) SdhD YP_001849515.1 1459762 R 216594 CDS YP_001849516.1 183981225 6225458 complement(1460226..1460564) 1 NC_010612.1 involved in tricarboxylic acid cycle. mono-heme cytochrome of the succinate dehydrogenase complex; succinate dehydrogenase (cytochrome B-556 subunit) SdhC 1460564 sdhC 6225458 sdhC Mycobacterium marinum M succinate dehydrogenase (cytochrome B-556 subunit) SdhC YP_001849516.1 1460226 R 216594 CDS YP_001849517.1 183981226 6225459 1460868..1461266 1 NC_010612.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 1461266 cdd 6225459 cdd Mycobacterium marinum M cytidine deaminase YP_001849517.1 1460868 D 216594 CDS YP_001849518.1 183981227 6225460 1461263..1462564 1 NC_010612.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 1462564 deoA 6225460 deoA Mycobacterium marinum M thymidine phosphorylase YP_001849518.1 1461263 D 216594 CDS YP_001849519.1 183981228 6225461 1462561..1463649 1 NC_010612.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 1463649 add 6225461 add Mycobacterium marinum M adenosine deaminase YP_001849519.1 1462561 D 216594 CDS YP_001849520.1 183981229 6225462 complement(1463658..1466498) 1 NC_010612.1 PE-PGRS family protein 1466498 6225462 MMAR_1207 Mycobacterium marinum M PE-PGRS family protein YP_001849520.1 1463658 R 216594 CDS YP_001849521.1 183981230 6225463 complement(1466768..1469659) 1 NC_010612.1 PE-PGRS family protein 1469659 6225463 MMAR_1208 Mycobacterium marinum M PE-PGRS family protein YP_001849521.1 1466768 R 216594 CDS YP_001849522.1 183981231 6225464 1469836..1471092 1 NC_010612.1 hypothetical protein 1471092 6225464 MMAR_1209 Mycobacterium marinum M hypothetical protein YP_001849522.1 1469836 D 216594 CDS YP_001849523.1 183981232 6225465 1471089..1472048 1 NC_010612.1 catalyzes the formation of S-ureidoglycolate and urea from allantoate; allantoicase 1472048 alc 6225465 alc Mycobacterium marinum M allantoicase YP_001849523.1 1471089 D 216594 CDS YP_001849524.1 183981233 6225466 1472045..1472956 1 NC_010612.1 function unknown, contains xylanase/chitin deacetylase domain; chitinase 1472956 6225466 MMAR_1211 Mycobacterium marinum M chitinase YP_001849524.1 1472045 D 216594 CDS YP_001849525.1 183981234 6225467 complement(1472935..1474461) 1 NC_010612.1 function unknown but contains permease domain and may be involved in nucleotide transport (cytosine/purines) and metabolism/coenzyme metabolism; hypothetical protein 1474461 6225467 MMAR_1212 Mycobacterium marinum M hypothetical protein YP_001849525.1 1472935 R 216594 CDS YP_001849526.1 183981235 6225468 complement(1474570..1476069) 1 NC_010612.1 function unknown. thought to be regulated by LexA; 13e12 repeat-containing protein 1476069 6225468 MMAR_1213 Mycobacterium marinum M 13e12 repeat-containing protein YP_001849526.1 1474570 R 216594 CDS YP_001849527.1 183981236 6225469 1476139..1477035 1 NC_010612.1 function unknown but contains hydrolase domain; hypothetical protein 1477035 6225469 MMAR_1214 Mycobacterium marinum M hypothetical protein YP_001849527.1 1476139 D 216594 CDS YP_001849528.1 183981237 6225470 complement(1477124..1478449) 1 NC_010612.1 hypothetical protein 1478449 6225470 MMAR_1215 Mycobacterium marinum M hypothetical protein YP_001849528.1 1477124 R 216594 CDS YP_001849529.1 183981238 6225471 complement(1478498..1479385) 1 NC_010612.1 involved in cellular metabolism: acting on ester bonds [catalytic activity: an orthophosphoric monoester + H(2)O = an alcohol + orthophosphate]; acid phosphatase 1479385 6225471 MMAR_1216 Mycobacterium marinum M acid phosphatase YP_001849529.1 1478498 R 216594 CDS YP_001849530.1 183981239 6225472 1479477..1480100 1 NC_010612.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 1480100 upp 6225472 upp Mycobacterium marinum M uracil phosphoribosyltransferase YP_001849530.1 1479477 D 216594 CDS YP_001849531.1 183981240 6225473 complement(1480102..1481682) 1 NC_010612.1 converts D-mannose 1-phosphate to D-mannose 6- phosphate; phosphomannomutase 1481682 pmmB 6225473 pmmB Mycobacterium marinum M phosphomannomutase YP_001849531.1 1480102 R 216594 CDS YP_001849532.1 183981241 6225474 complement(1481672..1482493) 1 NC_010612.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 1482493 deoD 6225474 deoD Mycobacterium marinum M purine nucleoside phosphorylase YP_001849532.1 1481672 R 216594 CDS YP_001849533.1 183981242 6225475 1482576..1483757 1 NC_010612.1 involved in cellular metabolism, active on carbon aliphatic amides and/or on many aromatic amides [catalytic activity : a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)]; amidohydrolase 1483757 amiB1 6225475 amiB1 Mycobacterium marinum M amidohydrolase YP_001849533.1 1482576 D 216594 CDS YP_001849534.1 183981243 6225476 1483754..1484923 1 NC_010612.1 function unknown, hydrolysis of L-amino acids; N-acyl-L-amino acid amidohydrolase AmiA1 1484923 amiA1 6225476 amiA1 Mycobacterium marinum M N-acyl-L-amino acid amidohydrolase AmiA1 YP_001849534.1 1483754 D 216594 CDS YP_001849535.1 183981244 6225477 1485035..1485922 1 NC_010612.1 hypothetical protein 1485922 6225477 MMAR_1222 Mycobacterium marinum M hypothetical protein YP_001849535.1 1485035 D 216594 CDS YP_001849536.1 183981245 6225478 complement(1486014..1486493) 1 NC_010612.1 hypothetical protein 1486493 6225478 MMAR_1223 Mycobacterium marinum M hypothetical protein YP_001849536.1 1486014 R 216594 CDS YP_001849537.1 183981246 6225479 1486638..1488047 1 NC_010612.1 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase 1488047 lpdA 6225479 lpdA Mycobacterium marinum M flavoprotein disulfide reductase YP_001849537.1 1486638 D 216594 CDS YP_001849538.1 183981247 6225480 1488132..1489889 1 NC_010612.1 involved in aerobic respiration and oxydation of glycerol. reduces an acceptor and generates glycerone phosphate from SN-glycerol 3-phosphate. possibly play a role in metabolism of riboflavin, fad,FMN [catalytic activity: SN-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor]; glycerol-3-phosphate dehydrogenase GlpD2 1489889 glpD2 6225480 glpD2 Mycobacterium marinum M glycerol-3-phosphate dehydrogenase GlpD2 YP_001849538.1 1488132 D 216594 CDS YP_001849539.1 183981248 6225481 1490297..1491841 1 NC_010612.1 function unknown but may be involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]; glutamate synthase, GltB 1491841 gltB_1 6225481 gltB_1 Mycobacterium marinum M glutamate synthase, GltB YP_001849539.1 1490297 D 216594 CDS YP_001849540.1 183981249 6225482 complement(1491849..1492487) 1 NC_010612.1 hypothetical protein 1492487 6225482 MMAR_1227 Mycobacterium marinum M hypothetical protein YP_001849540.1 1491849 R 216594 CDS YP_001849541.1 183981250 6225483 complement(1492620..1497083) 1 NC_010612.1 metal cation-transporting ATPase; possibly catalyzes the transport of undeterminated metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation transporting p-type ATPase CtpH 1497083 ctpH_1 6225483 ctpH_1 Mycobacterium marinum M metal cation transporting p-type ATPase CtpH YP_001849541.1 1492620 R 216594 CDS YP_001849542.1 183981251 6225484 1497403..1498068 1 NC_010612.1 involved in transcriptional regulation of active transport of inorganic phosphate across the membrane; phosphate-transport system transcriptional regulatory protein PhoY1 1498068 phoY1 6225484 phoY1 Mycobacterium marinum M phosphate-transport system transcriptional regulatory protein PhoY1 YP_001849542.1 1497403 D 216594 CDS YP_001849543.1 183981252 6225485 1498110..1499108 1 NC_010612.1 thought to be involved in transport of magnesium and cobalt ions across the membrane. responsible for the translocation of the substrate across the membrane; magnesium and cobalt transport transmembrane protein CorA 1499108 corA_1 6225485 corA_1 Mycobacterium marinum M magnesium and cobalt transport transmembrane protein CorA YP_001849543.1 1498110 D 216594 CDS YP_001849544.1 183981253 6225486 1499313..1500179 1 NC_010612.1 catalyses the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); pseudouridine synthase 1500179 6225486 MMAR_1231 Mycobacterium marinum M pseudouridine synthase YP_001849544.1 1499313 D 216594 CDS YP_001849545.1 183981254 6225487 1500201..1503104 1 NC_010612.1 generates sulfate and phenol from phenol sulfate [catalytic activity: a phenol sulfate + H(2)O = a phenol + sulfate]; arylsulfatase AtsB 1503104 atsB 6225487 atsB Mycobacterium marinum M arylsulfatase AtsB YP_001849545.1 1500201 D 216594 CDS YP_001849546.1 183981255 6225488 complement(1503126..1503446) 1 NC_010612.1 hypothetical protein 1503446 6225488 MMAR_1233 Mycobacterium marinum M hypothetical protein YP_001849546.1 1503126 R 216594 CDS YP_001849547.1 183981256 6225489 1503707..1504819 1 NC_010612.1 involved in active transport of inorganic phosphate across the membrane (import). this is one of the proteins required for binding-protein-mediated phosphate transport; periplasmic phosphate-binding lipoprotein PhoS2 1504819 phoS2_1 6225489 phoS2_1 Mycobacterium marinum M periplasmic phosphate-binding lipoprotein PhoS2 YP_001849547.1 1503707 D 216594 CDS YP_001849548.1 183981257 6225490 1504905..1506035 1 NC_010612.1 function unknown. possibly a protective antigen involved with the early control of infection; PPE family protein 1506035 6225490 MMAR_1235 Mycobacterium marinum M PPE family protein YP_001849548.1 1504905 D 216594 CDS YP_001849549.1 183981258 6225491 1506088..1507005 1 NC_010612.1 function unknown, lipolytic enzyme involved in cellular metabolism; esterase lipoprotein LpqC 1507005 lpqC 6225491 lpqC Mycobacterium marinum M esterase lipoprotein LpqC YP_001849549.1 1506088 D 216594 CDS YP_001849550.1 183981259 6225492 complement(1507020..1507784) 1 NC_010612.1 involved in damage reversal. DNA N-glycosylase with an ap lyase activity. required for the repair of oxidative DNA damage (oxidized pyrimidines); endonuclease VIII Nei 1507784 nei 6225492 nei Mycobacterium marinum M endonuclease VIII Nei YP_001849550.1 1507020 R 216594 CDS YP_001849551.1 183981260 6225493 complement(1507788..1512407) 1 NC_010612.1 function unknown but has both ATPase and helicase activities; ATP-dependent helicase Lhr 1512407 lhr 6225493 lhr Mycobacterium marinum M ATP-dependent helicase Lhr YP_001849551.1 1507788 R 216594 CDS YP_001849552.1 183981261 6225494 complement(1512440..1513114) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 1513114 6225494 MMAR_1239 Mycobacterium marinum M TetR family transcriptional regulator YP_001849552.1 1512440 R 216594 CDS YP_001849553.1 183981262 6225495 complement(1513163..1514677) 1 NC_010612.1 involved in L-alpha-aminoadipic acid (L-AAA) biosynthesis (in the second step; the first step is promoted by Lat enzyme; piperideine-6-carboxilic acid dehydrogenase Pcd 1514677 pcd 6225495 pcd Mycobacterium marinum M piperideine-6-carboxilic acid dehydrogenase Pcd YP_001849553.1 1513163 R 216594 CDS YP_001849554.1 183981263 6225496 complement(1514755..1516026) 1 NC_010612.1 hypothetical protein 1516026 6225496 MMAR_1241 Mycobacterium marinum M hypothetical protein YP_001849554.1 1514755 R 216594 CDS YP_001849555.1 183981264 6225497 1516060..1516512 1 NC_010612.1 involved in transcriptional mechanism; AsnC family transcriptional regulator 1516512 6225497 MMAR_1242 Mycobacterium marinum M AsnC family transcriptional regulator YP_001849555.1 1516060 D 216594 CDS YP_001849556.1 183981265 6225498 1516566..1517906 1 NC_010612.1 catalyzes the formation of 2-aminoadipate 6-semiladehyde and glutamate from lysine and 2-oxoglutarate; L-lysine aminotransferase 1517906 lat 6225498 lat Mycobacterium marinum M L-lysine aminotransferase YP_001849556.1 1516566 D 216594 CDS YP_001849557.1 183981266 6225499 1517986..1518372 1 NC_010612.1 hypothetical protein 1518372 6225499 MMAR_1244 Mycobacterium marinum M hypothetical protein YP_001849557.1 1517986 D 216594 CDS YP_001849558.1 183981267 6225500 1518485..1518796 1 NC_010612.1 hypothetical protein 1518796 usfY 6225500 usfY Mycobacterium marinum M hypothetical protein YP_001849558.1 1518485 D 216594 CDS YP_001849559.1 183981268 6225501 1518992..1519204 1 NC_010612.1 hypothetical protein 1519204 6225501 MMAR_1246 Mycobacterium marinum M hypothetical protein YP_001849559.1 1518992 D 216594 CDS YP_001849560.1 183981269 6225502 1519201..1519719 1 NC_010612.1 binds to sigma and blocks its ability to form an RNA polymerase holoenzyme. regulates negatively SigF and negatively regulated by RsfA and RsfB; anti-sigma factor RsbW 1519719 rsbW 6225502 rsbW Mycobacterium marinum M anti-sigma factor RsbW YP_001849560.1 1519201 D 216594 CDS YP_001849561.1 183981270 6225503 1519716..1520504 1 NC_010612.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock; RNA polymerase sigma factor SigF 1520504 sigF 6225503 sigF Mycobacterium marinum M RNA polymerase sigma factor SigF YP_001849561.1 1519716 D 216594 CDS YP_001849562.1 183981271 6225504 complement(1520566..1521135) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 1521135 6225504 MMAR_1249 Mycobacterium marinum M transcriptional regulatory protein YP_001849562.1 1520566 R 216594 CDS YP_001849563.1 183981272 6225505 1521763..1531236 1 NC_010612.1 function unknown but contains 3 modules for the potential synthesis of a tripeptide; peptide synthetase Nrp (peptide synthase) 1531236 6225505 MMAR_1250 Mycobacterium marinum M peptide synthetase Nrp (peptide synthase) YP_001849563.1 1521763 D 216594 CDS YP_001849564.1 183981273 6225506 complement(1531258..1533051) 1 NC_010612.1 involved in long-chain fatty acid synthesis (at the first step). carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + orthophosphate + carboxybiotin-carboxyl-carrier protein]; bifunctional protein acetyl-/propionyl-coenzyme A carboxylase alpha chain AccA3 1533051 accA3 6225506 accA3 Mycobacterium marinum M bifunctional protein acetyl-/propionyl-coenzyme A carboxylase alpha chain AccA3 YP_001849564.1 1531258 R 216594 CDS YP_001849565.1 183981274 6225507 complement(1533162..1533581) 1 NC_010612.1 probably involved in Fe-S center assembly; Fe-S metabolism associated protein, SufE 1533581 sufE 6225507 sufE Mycobacterium marinum M Fe-S metabolism associated protein, SufE YP_001849565.1 1533162 R 216594 CDS YP_001849566.1 183981275 6225508 complement(1533578..1534483) 1 NC_010612.1 possibly a sulfotransferase involved in the formation of thiosulfate [catalytic activity: thiosulfate + cyanide = sulfite + thiocyanate]; thiosulfate sulfurtransferase SseA 1534483 sseA 6225508 sseA Mycobacterium marinum M thiosulfate sulfurtransferase SseA YP_001849566.1 1533578 R 216594 CDS YP_001849567.1 183981276 6225509 complement(1534523..1535173) 1 NC_010612.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1535173 6225509 MMAR_1254 Mycobacterium marinum M Maf-like protein YP_001849567.1 1534523 R 216594 CDS YP_001849568.1 183981277 6225510 complement(1535170..1535490) 1 NC_010612.1 hypothetical protein 1535490 6225510 MMAR_1255 Mycobacterium marinum M hypothetical protein YP_001849568.1 1535170 R 216594 CDS YP_001849569.1 183981278 6225511 complement(1535487..1537127) 1 NC_010612.1 key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA.]; propionyl-CoA carboxylase beta chain 5 AccD5 1537127 accD5 6225511 accD5 Mycobacterium marinum M propionyl-CoA carboxylase beta chain 5 AccD5 YP_001849569.1 1535487 R 216594 CDS YP_001849570.1 183981279 6225512 1537278..1538108 1 NC_010612.1 BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl- CoA:carbon-dioxide ligase. this protein also activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins [catalytic activity: ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP forming)] = AMP + pyrophosphate + [acetyl- CoA:carbon-dioxide ligase (ADP forming)]]; bifunctional protein BirA 1538108 birA 6225512 birA Mycobacterium marinum M bifunctional protein BirA YP_001849570.1 1537278 D 216594 CDS YP_001849571.1 183981280 6225513 1538171..1538689 1 NC_010612.1 hypothetical protein 1538689 6225513 MMAR_1258 Mycobacterium marinum M hypothetical protein YP_001849571.1 1538171 D 216594 CDS YP_001849572.1 183981281 6225514 complement(1538644..1539288) 1 NC_010612.1 hypothetical protein 1539288 6225514 MMAR_1259 Mycobacterium marinum M hypothetical protein YP_001849572.1 1538644 R 216594 CDS YP_001849573.1 183981282 6225515 1539427..1540641 1 NC_010612.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 1540641 purK 6225515 purK Mycobacterium marinum M phosphoribosylaminoimidazole carboxylase ATPase subunit YP_001849573.1 1539427 D 216594 CDS YP_001849574.1 183981283 6225516 1540634..1541149 1 NC_010612.1 involved in purine biosynthesis (sixth step). this subunit can alone transform air to cair, but in association with PurK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting air to cair efficiently under physiol; phosphoribosylaminoimidazole carboxylase catalytic subunit PurE 1541149 purE 6225516 purE Mycobacterium marinum M phosphoribosylaminoimidazole carboxylase catalytic subunit PurE YP_001849574.1 1540634 D 216594 CDS YP_001849575.1 183981284 6225517 1541174..1542343 1 NC_010612.1 function unknown, but involved in lipid metabolism [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF]; acyl-CoA dehydrogenase FadE25 1542343 fadE25 6225517 fadE25 Mycobacterium marinum M acyl-CoA dehydrogenase FadE25 YP_001849575.1 1541174 D 216594 CDS YP_001849576.1 183981285 6225518 1542537..1543775 1 NC_010612.1 hypothetical protein 1543775 6225518 MMAR_1263 Mycobacterium marinum M hypothetical protein YP_001849576.1 1542537 D 216594 CDS YP_001849577.1 183981286 6225519 1543772..1545394 1 NC_010612.1 two-component system membrane associated sensor kinase 1545394 6225519 MMAR_1264 Mycobacterium marinum M two-component system membrane associated sensor kinase YP_001849577.1 1543772 D 216594 CDS YP_001849578.1 183981287 6225520 1545391..1545831 1 NC_010612.1 sensor part of the two-component regulatory system; two-component transcriptional regulator 1545831 6225520 MMAR_1265 Mycobacterium marinum M two-component transcriptional regulator YP_001849578.1 1545391 D 216594 CDS YP_001849579.1 183981288 6225521 complement(1545845..1548091) 1 NC_010612.1 generates CO(2) and H(2)O from H(2)CO(3), and possibly involved in transport of sulfate across the membrane; transmembrane carbonic anhydrase, SulP_2 1548091 sulP_2 6225521 sulP_2 Mycobacterium marinum M transmembrane carbonic anhydrase, SulP_2 YP_001849579.1 1545845 R 216594 CDS YP_001849580.1 183981289 6225522 complement(1548369..1549556) 1 NC_010612.1 acyl-CoA transferase 1549556 6225522 MMAR_1267 Mycobacterium marinum M acyl-CoA transferase YP_001849580.1 1548369 R 216594 CDS YP_001849581.1 183981290 6225523 complement(1549733..1550389) 1 NC_010612.1 putative regulatory protein 1550389 6225523 MMAR_1268 Mycobacterium marinum M putative regulatory protein YP_001849581.1 1549733 R 216594 CDS YP_001849582.1 183981291 6225524 1550462..1552168 1 NC_010612.1 acyl esterase 1552168 6225524 MMAR_1269 Mycobacterium marinum M acyl esterase YP_001849582.1 1550462 D 216594 CDS YP_001849583.1 183981292 6225525 1552229..1552948 1 NC_010612.1 hypothetical protein 1552948 6225525 MMAR_1270 Mycobacterium marinum M hypothetical protein YP_001849583.1 1552229 D 216594 CDS YP_001849584.1 183981293 6225526 complement(1552992..1555190) 1 NC_010612.1 metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation-transporting p-type ATPase CtpC 1555190 ctpC 6225526 ctpC Mycobacterium marinum M metal cation-transporting p-type ATPase CtpC YP_001849584.1 1552992 R 216594 CDS YP_001849585.1 183981294 6225527 complement(1555200..1555478) 1 NC_010612.1 function unknown; hypothetical protein 1555478 6225527 MMAR_1272 Mycobacterium marinum M hypothetical protein YP_001849585.1 1555200 R 216594 CDS YP_001849586.1 183981295 6225528 complement(1555594..1556274) 1 NC_010612.1 hypothetical protein 1556274 6225528 MMAR_1273 Mycobacterium marinum M hypothetical protein YP_001849586.1 1555594 R 216594 CDS YP_001849587.1 183981296 6225529 complement(1556304..1557761) 1 NC_010612.1 hypothetical protein 1557761 6225529 MMAR_1274 Mycobacterium marinum M hypothetical protein YP_001849587.1 1556304 R 216594 CDS YP_001849588.1 183981297 6225530 1557829..1558755 1 NC_010612.1 involved in dTDP-L-rhamnose biosynthesis: converts dTDP-6-deoxy-L-lyxo-4-hexulose to dTDP-L-rhamnose with the concomitant oxidation of NADPH to NADP+ [catalytic activity: dTDP-6-deoxy-L-lyxo-4-hexulose + NADPH = dTDP-L- rhamnose + NADP+]; dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD 1558755 rmlD 6225530 rmlD Mycobacterium marinum M dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD YP_001849588.1 1557829 D 216594 CDS YP_001849589.1 183981298 6225531 1558748..1559632 1 NC_010612.1 involved in cell wall arabinogalactan linker formation: uses dTDP-L-rhamnose as substrate to insert the rhamnosyl residue into the cell wall. seems to be essential for mycobacterial viability; dTDP-rha:A-D-GlcNAc-diphosphoryl polyprenol A-3- L-rhamnosyl transferase, WbbL1 1559632 wbbL1 6225531 wbbL1 Mycobacterium marinum M dTDP-rha:A-D-GlcNAc-diphosphoryl polyprenol A-3- L-rhamnosyl transferase, WbbL1 YP_001849589.1 1558748 D 216594 CDS YP_001849590.1 183981299 6225532 1559634..1560710 1 NC_010612.1 involved in GDP-mannose biosynthesis and biosynthesis of nucleotide-activated glycero-manno-heptose (D-alpha-D pathway): generates GDP-mannose and phosphate from GTP and alpha-D-mannose 1-phosphate. ManB product is needed for all mannosyl glycolipids and polysaccharides which, like rhamnosyl residues, are an important part of the mycobacterium envelope [catalytic activity: alpha-D- mannose 1-phosphate + GTP = GDP-mannose + phosphate]; d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 1560710 manB 6225532 manB Mycobacterium marinum M d-alpha-D-mannose-1-phosphate guanylyltransferase ManB YP_001849590.1 1559634 D 216594 CDS YP_001849591.1 183981300 6225533 complement(1560739..1561287) 1 NC_010612.1 hypothetical protein 1561287 6225533 MMAR_1278 Mycobacterium marinum M hypothetical protein YP_001849591.1 1560739 R 216594 CDS YP_001849592.1 183981301 6225534 complement(1561284..1562870) 1 NC_010612.1 causes DNA methylation; DNA methylase 1562870 6225534 MMAR_1279 Mycobacterium marinum M DNA methylase YP_001849592.1 1561284 R 216594 CDS YP_001849593.1 183981302 6225535 complement(1562899..1564263) 1 NC_010612.1 catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0); F420-0--gamma-glutamyl ligase 1564263 fbiB 6225535 fbiB Mycobacterium marinum M F420-0--gamma-glutamyl ligase YP_001849593.1 1562899 R 216594 CDS YP_001849594.1 183981303 6225536 complement(1564260..1565249) 1 NC_010612.1 catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); LPPG:FO 2-phospho-L-lactate transferase 1565249 fbiA 6225536 fbiA Mycobacterium marinum M LPPG:FO 2-phospho-L-lactate transferase YP_001849594.1 1564260 R 216594 CDS YP_001849595.1 183981304 6225537 1565642..1566025 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein Whib-like WhiB2 1566025 whiB2 6225537 whiB2 Mycobacterium marinum M transcriptional regulatory protein Whib-like WhiB2 YP_001849595.1 1565642 D 216594 CDS YP_001849596.1 183981305 6225538 complement(1566091..1566621) 1 NC_010612.1 hypothetical protein 1566621 6225538 MMAR_1283 Mycobacterium marinum M hypothetical protein YP_001849596.1 1566091 R 216594 CDS YP_001849597.1 183981306 6225539 1566636..1567133 1 NC_010612.1 hypothetical protein 1567133 6225539 MMAR_1284 Mycobacterium marinum M hypothetical protein YP_001849597.1 1566636 D 216594 CDS YP_001849598.1 183981307 6225540 1567280..1568680 1 NC_010612.1 converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase 1568680 manB 6225540 manB Mycobacterium marinum M phosphomannomutase YP_001849598.1 1567280 D 216594 CDS YP_001849599.1 183981308 6225541 1568677..1569786 1 NC_010612.1 hypothetical protein 1569786 6225541 MMAR_1286 Mycobacterium marinum M hypothetical protein YP_001849599.1 1568677 D 216594 CDS YP_001849600.1 183981309 6225542 1569794..1571020 1 NC_010612.1 this enzyme converts D-mannose 6-phosphate to D- fructose 6-phosphate [catalytic activity: D-mannose 6- phosphate = D-fructose 6-phosphate]; mannose-6-phosphate isomerase ManA 1571020 manA 6225542 manA Mycobacterium marinum M mannose-6-phosphate isomerase ManA YP_001849600.1 1569794 D 216594 CDS YP_001849601.1 183981310 6225543 complement(1570998..1572419) 1 NC_010612.1 function unknown but contains dehydrogenase domain; hypothetical protein 1572419 6225543 MMAR_1288 Mycobacterium marinum M hypothetical protein YP_001849601.1 1570998 R 216594 CDS YP_001849602.1 183981311 6225544 complement(1572450..1573844) 1 NC_010612.1 hypothetical protein 1573844 6225544 MMAR_1289 Mycobacterium marinum M hypothetical protein YP_001849602.1 1572450 R 216594 CDS YP_001849603.1 183981312 6225545 1573901..1575385 1 NC_010612.1 thought to be involved in cationic amino acid transport across the membrane. responsible for the translocation of the substrate across the membrane; cationic amino acid transport integral membrane protein 1575385 6225545 MMAR_1290 Mycobacterium marinum M cationic amino acid transport integral membrane protein YP_001849603.1 1573901 D 216594 CDS YP_001849604.1 183981313 6225546 1575496..1576746 1 NC_010612.1 thought to be involved in fatty acid metabolism. generates octanol and oxidized rubredoxin from octane and reduced rubredoxin. also hydroxylates fatty acids in the omega-position [catalytic activity: octane + reduced rubredoxin + (O)2 = 1-octanol + oxidized rubredoxin + H(2)O]; transmembrane alkane 1-monooxygenase AlkB 1576746 alkB 6225546 alkB Mycobacterium marinum M transmembrane alkane 1-monooxygenase AlkB YP_001849604.1 1575496 D 216594 CDS YP_001849605.1 183981314 6225547 1576746..1576916 1 NC_010612.1 involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase; rubredoxin RubA 1576916 rubA 6225547 rubA Mycobacterium marinum M rubredoxin RubA YP_001849605.1 1576746 D 216594 CDS YP_001849606.1 183981315 6225548 1576917..1577099 1 NC_010612.1 involved in the hydrocarbon hydroxylating system to convert conversion of dodecane to lauric acid, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase; rubredoxin RubB 1577099 rubB 6225548 rubB Mycobacterium marinum M rubredoxin RubB YP_001849606.1 1576917 D 216594 CDS YP_001849607.1 183981316 6225549 1577096..1577746 1 NC_010612.1 probably involved in a transcriptional mechanism; TetR family transcriptional regulator 1577746 6225549 MMAR_1294 Mycobacterium marinum M TetR family transcriptional regulator YP_001849607.1 1577096 D 216594 CDS YP_001849608.1 183981317 6225550 1577851..1579329 1 NC_010612.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 1579329 sahH 6225550 sahH Mycobacterium marinum M S-adenosyl-L-homocysteine hydrolase YP_001849608.1 1577851 D 216594 CDS YP_001849609.1 183981318 6225551 1579673..1580272 1 NC_010612.1 PE-PGRS family protein 1580272 6225551 MMAR_1296 Mycobacterium marinum M PE-PGRS family protein YP_001849609.1 1579673 D 216594 CDS YP_001849610.1 183981319 6225552 1580673..1582757 1 NC_010612.1 PPE family protein 1582757 6225552 MMAR_1297 Mycobacterium marinum M PPE family protein YP_001849610.1 1580673 D 216594 CDS YP_001849611.1 183981320 6225553 1582821..1583474 1 NC_010612.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1583474 tmk 6225553 tmk Mycobacterium marinum M thymidylate kinase YP_001849611.1 1582821 D 216594 CDS YP_001849612.1 183981321 6225554 1583554..1584231 1 NC_010612.1 transcriptional activator part of a two-component regulatory system; two-component sensory transduction transcriptional regulatory protein MtrA 1584231 mtrA 6225554 mtrA Mycobacterium marinum M two-component sensory transduction transcriptional regulatory protein MtrA YP_001849612.1 1583554 D 216594 CDS YP_001849613.1 183981322 6225555 1584281..1585960 1 NC_010612.1 sensor part of a two-component regulatory system; two-component sensory transduction histidine kinase MtrB 1585960 mtrB 6225555 mtrB Mycobacterium marinum M two-component sensory transduction histidine kinase MtrB YP_001849613.1 1584281 D 216594 CDS YP_001849614.1 183981323 6225556 1585960..1587738 1 NC_010612.1 lipoprotein LpqB 1587738 lpqB 6225556 lpqB Mycobacterium marinum M lipoprotein LpqB YP_001849614.1 1585960 D 216594 CDS YP_001849615.1 183981324 6225557 1587799..1588629 1 NC_010612.1 hypothetical protein 1588629 6225557 MMAR_1302 Mycobacterium marinum M hypothetical protein YP_001849615.1 1587799 D 216594 CDS YP_001849616.1 183981325 6225558 1588672..1589307 1 NC_010612.1 function unknown, but contains amidophosphoribosyltransferase domain; hypothetical protein 1589307 6225558 MMAR_1303 Mycobacterium marinum M hypothetical protein YP_001849616.1 1588672 D 216594 CDS YP_001849617.1 183981326 6225559 1589649..1590338 1 NC_010612.1 function unknown but has domain identity with sigma 54 modulation protein; hypothetical protein 1590338 6225559 MMAR_1304 Mycobacterium marinum M hypothetical protein YP_001849617.1 1589649 D 216594 CDS YP_001849618.1 183981327 6225560 1590435..1593287 1 NC_010612.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1593287 secA1 6225560 secA1 Mycobacterium marinum M preprotein translocase subunit SecA YP_001849618.1 1590435 D 216594 CDS YP_001849619.1 183981328 6225561 1593372..1596602 1 NC_010612.1 function unknown, but seems involved in efflux system (probably sugar or drug transport); transmembrane transport protein 1596602 6225561 MMAR_1306 Mycobacterium marinum M transmembrane transport protein YP_001849619.1 1593372 D 216594 CDS YP_001849620.1 183981329 6225562 1596659..1597414 1 NC_010612.1 hypothetical protein 1597414 6225562 MMAR_1307 Mycobacterium marinum M hypothetical protein YP_001849620.1 1596659 D 216594 CDS YP_001849621.1 183981330 6225563 1597486..1597968 1 NC_010612.1 function unknown but has a putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [inorganic ion transport and metabolism]; hypothetical protein 1597968 6225563 MMAR_1308 Mycobacterium marinum M hypothetical protein YP_001849621.1 1597486 D 216594 CDS YP_001849622.1 183981331 6225564 1597973..1599118 1 NC_010612.1 probably involved in transport of undeterminated substrate (possibly cations Na/H) across the membrane. thought to be responsible for the translocation of the substrate across the membrane; membrane transporter 1599118 6225564 MMAR_1309 Mycobacterium marinum M membrane transporter YP_001849622.1 1597973 D 216594 CDS YP_001849623.1 183981332 6225565 complement(1599136..1599774) 1 NC_010612.1 hypothetical protein 1599774 6225565 MMAR_1310 Mycobacterium marinum M hypothetical protein YP_001849623.1 1599136 R 216594 CDS YP_001849624.1 183981333 6225566 1599882..1601300 1 NC_010612.1 hypothetical protein 1601300 6225566 MMAR_1311 Mycobacterium marinum M hypothetical protein YP_001849624.1 1599882 D 216594 CDS YP_001849625.1 183981334 6225567 1601343..1602215 1 NC_010612.1 possibly involved in transcriptional mechanism (probably sigma factor promoting attachment of the RNA polymerase to specific initiation sites); transcriptional regulatory protein PvdS 1602215 pvdS 6225567 pvdS Mycobacterium marinum M transcriptional regulatory protein PvdS YP_001849625.1 1601343 D 216594 CDS YP_001849626.1 183981335 6225568 1602281..1602781 1 NC_010612.1 hypothetical protein 1602781 6225568 MMAR_1313 Mycobacterium marinum M hypothetical protein YP_001849626.1 1602281 D 216594 CDS YP_001849627.1 183981336 6225569 1602922..1604076 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 1604076 6225569 MMAR_1314 Mycobacterium marinum M oxidoreductase YP_001849627.1 1602922 D 216594 CDS YP_001849628.1 183981337 6225570 1604165..1605451 1 NC_010612.1 thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O]; linoleoyl-CoA desaturase, DesA3 1605451 desA3 6225570 desA3 Mycobacterium marinum M linoleoyl-CoA desaturase, DesA3 YP_001849628.1 1604165 D 216594 CDS YP_001849629.1 183981338 6225571 1605681..1606967 1 NC_010612.1 thought to be involved in lipid metabolism [catalytic activity: linoleoyl-CoA + ah(2) + O(2) = gamma- linolenoyl-CoA + a + 2 H(2)O]; linoleoyl-CoA desaturase, DesA3 1606967 desA3_1 6225571 desA3_1 Mycobacterium marinum M linoleoyl-CoA desaturase, DesA3 YP_001849629.1 1605681 D 216594 CDS YP_001849630.1 183981339 6225572 complement(1607005..1608186) 1 NC_010612.1 function unknown, but involved in lipid metabolism [catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl- CoA]; acetyl-CoA acetyltransferase FadA6_4 1608186 fadA6_4 6225572 fadA6_4 Mycobacterium marinum M acetyl-CoA acetyltransferase FadA6_4 YP_001849630.1 1607005 R 216594 CDS YP_001849631.1 183981340 6225573 1608281..1608748 1 NC_010612.1 function unknown. could be involved in regulatory mechanism; transcriptional regulatory protein 1608748 6225573 MMAR_1318 Mycobacterium marinum M transcriptional regulatory protein YP_001849631.1 1608281 D 216594 CDS YP_001849632.1 183981341 6225574 complement(1608735..1609727) 1 NC_010612.1 hypothetical protein 1609727 6225574 MMAR_1319 Mycobacterium marinum M hypothetical protein YP_001849632.1 1608735 R 216594 CDS YP_001849633.1 183981342 6225575 complement(1609724..1611019) 1 NC_010612.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1611019 aroA 6225575 aroA Mycobacterium marinum M 3-phosphoshikimate 1-carboxyvinyltransferase YP_001849633.1 1609724 R 216594 CDS YP_001849634.1 183981343 6225576 1611065..1611847 1 NC_010612.1 hypothetical protein 1611847 6225576 MMAR_1321 Mycobacterium marinum M hypothetical protein YP_001849634.1 1611065 D 216594 CDS YP_001849635.1 183981344 6225577 1611945..1612829 1 NC_010612.1 thought to be involved in fatty acid degradation. FadB and FadA are the alpha and beta subunits of the multifunctional enzyme complex of the fatty acid degradation cycle [catalytic activity: (S)-3- hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH]; 3-hydroxybutyryl-CoA dehydrogenase FadB3 1612829 fadB3 6225577 fadB3 Mycobacterium marinum M 3-hydroxybutyryl-CoA dehydrogenase FadB3 YP_001849635.1 1611945 D 216594 CDS YP_001849636.1 183981345 6225578 1612894..1614174 1 NC_010612.1 hypothetical protein 1614174 6225578 MMAR_1323 Mycobacterium marinum M hypothetical protein YP_001849636.1 1612894 D 216594 CDS YP_001849637.1 183981346 6225579 1614279..1614602 1 NC_010612.1 hypothetical protein 1614602 6225579 MMAR_5565 Mycobacterium marinum M hypothetical protein YP_001849637.1 1614279 D 216594 CDS YP_001849638.1 183981347 6225580 1614985..1617714 1 NC_010612.1 may be involved in regulation; hypothetical protein 1617714 6225580 MMAR_1324 Mycobacterium marinum M hypothetical protein YP_001849638.1 1614985 D 216594 CDS YP_001849639.1 183981348 6225581 1618502..1619800 1 NC_010612.1 hypothetical protein 1619800 6225581 MMAR_1325 Mycobacterium marinum M hypothetical protein YP_001849639.1 1618502 D 216594 CDS YP_001849640.1 183981349 6225582 1619876..1620190 1 NC_010612.1 hypothetical protein 1620190 6225582 MMAR_1326 Mycobacterium marinum M hypothetical protein YP_001849640.1 1619876 D 216594 CDS YP_001849641.1 183981350 6225583 1620215..1620886 1 NC_010612.1 hypothetical protein 1620886 6225583 MMAR_1327 Mycobacterium marinum M hypothetical protein YP_001849641.1 1620215 D 216594 CDS YP_001849642.1 183981351 6225584 1621109..1621705 1 NC_010612.1 hypothetical protein 1621705 6225584 MMAR_1328 Mycobacterium marinum M hypothetical protein YP_001849642.1 1621109 D 216594 CDS YP_001849643.1 183981352 6225585 1621784..1623304 1 NC_010612.1 hypothetical protein 1623304 6225585 MMAR_1329 Mycobacterium marinum M hypothetical protein YP_001849643.1 1621784 D 216594 CDS YP_001849644.1 183981353 6225586 1623301..1623648 1 NC_010612.1 hypothetical protein 1623648 6225586 MMAR_1330 Mycobacterium marinum M hypothetical protein YP_001849644.1 1623301 D 216594 CDS YP_001849645.1 183981354 6225587 1623819..1625951 1 NC_010612.1 hypothetical protein 1625951 6225587 MMAR_1331 Mycobacterium marinum M hypothetical protein YP_001849645.1 1623819 D 216594 CDS YP_001849646.1 183981355 6225588 complement(1625977..1626432) 1 NC_010612.1 hypothetical protein 1626432 6225588 MMAR_1332 Mycobacterium marinum M hypothetical protein YP_001849646.1 1625977 R 216594 CDS YP_001849647.1 183981356 6225589 complement(1626444..1627292) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; short chain dehydrogenase 1627292 6225589 MMAR_1333 Mycobacterium marinum M short chain dehydrogenase YP_001849647.1 1626444 R 216594 CDS YP_001849648.1 183981357 6225590 1627492..1628259 1 NC_010612.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 1628259 sigH 6225590 sigH Mycobacterium marinum M RNA polymerase sigma factor RpoE YP_001849648.1 1627492 D 216594 CDS YP_001849649.1 183981358 6225591 1628256..1628561 1 NC_010612.1 binds sigma factor and inhibits it. probably involved in survival following heat shock and oxidative stress; anti-sigma factor 1628561 6225591 MMAR_1335 Mycobacterium marinum M anti-sigma factor YP_001849649.1 1628256 D 216594 CDS YP_001849650.1 183981359 6225592 1628923..1629138 1 NC_010612.1 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 1629138 6225592 MMAR_1336 Mycobacterium marinum M putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_001849650.1 1628923 D 216594 CDS YP_001849651.1 183981360 6225593 1629188..1630687 1 NC_010612.1 sensor part of a two-component regulatory system; sensor kinase from two-component regulatory system 1630687 6225593 MMAR_1337 Mycobacterium marinum M sensor kinase from two-component regulatory system YP_001849651.1 1629188 D 216594 CDS YP_001849652.1 183981361 6225594 complement(1630750..1631004) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein Whib-like WhiB1 1631004 whiB1 6225594 whiB1 Mycobacterium marinum M transcriptional regulatory protein Whib-like WhiB1 YP_001849652.1 1630750 R 216594 CDS YP_001849653.1 183981362 6225595 complement(1631288..1632253) 1 NC_010612.1 hypothetical protein 1632253 6225595 MMAR_1339 Mycobacterium marinum M hypothetical protein YP_001849653.1 1631288 R 216594 CDS YP_001849654.1 183981363 6225596 1632378..1632809 1 NC_010612.1 hypothetical protein 1632809 6225596 MMAR_1340 Mycobacterium marinum M hypothetical protein YP_001849654.1 1632378 D 216594 CDS YP_001849655.1 183981364 6225597 complement(1632761..1633243) 1 NC_010612.1 function unknown, involved in cellular metabolism; acetyltransferase 1633243 6225597 MMAR_1341 Mycobacterium marinum M acetyltransferase YP_001849655.1 1632761 R 216594 CDS YP_001849656.1 183981365 6225598 complement(1633240..1634340) 1 NC_010612.1 could be involved in enterobactin biosynthesis. enterobactin is an iron-chelating compound involved in transporting iron from the bacterial environment into the cell cytoplasm. could be also involved in 2,3- dihydroxybenzoate or enterochelin or menaquinone biosynthesis [catalytic activity: chorismate = isochorismate]; isochorismate synthase EntC 1634340 entC 6225598 entC Mycobacterium marinum M isochorismate synthase EntC YP_001849656.1 1633240 R 216594 CDS YP_001849657.1 183981366 6225599 complement(1634337..1634972) 1 NC_010612.1 forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily; acid phosphatase 1634972 gpm2 6225599 gpm2 Mycobacterium marinum M acid phosphatase YP_001849657.1 1634337 R 216594 CDS YP_001849658.1 183981367 6225600 1635013..1635813 1 NC_010612.1 possibly involved in control of chromosome partitioning; Soj/ParA-related protein 1635813 6225600 MMAR_1344 Mycobacterium marinum M Soj/ParA-related protein YP_001849658.1 1635013 D 216594 CDS YP_001849659.1 183981368 6225601 complement(1635836..1637050) 1 NC_010612.1 hypothetical protein 1637050 6225601 MMAR_1345 Mycobacterium marinum M hypothetical protein YP_001849659.1 1635836 R 216594 CDS YP_001849660.1 183981369 6225602 complement(1637065..1638618) 1 NC_010612.1 has a helix-destabilizing activity; ATP-dependent RNA helicase RhlE 1638618 rhlE 6225602 rhlE Mycobacterium marinum M ATP-dependent RNA helicase RhlE YP_001849660.1 1637065 R 216594 CDS YP_001849661.1 183981370 6225603 1638881..1639576 1 NC_010612.1 hypothetical protein 1639576 6225603 MMAR_1347 Mycobacterium marinum M hypothetical protein YP_001849661.1 1638881 D 216594 CDS YP_001849662.1 183981371 6225604 complement(1639589..1640569) 1 NC_010612.1 putative threonine and proline rich protein 1640569 6225604 MMAR_1348 Mycobacterium marinum M putative threonine and proline rich protein YP_001849662.1 1639589 R 216594 CDS YP_001849663.1 183981372 6225605 1640584..1640829 1 NC_010612.1 hypothetical protein 1640829 6225605 MMAR_1349 Mycobacterium marinum M hypothetical protein YP_001849663.1 1640584 D 216594 CDS YP_001849664.1 183981373 6225606 complement(1640826..1641509) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 1641509 6225606 MMAR_1350 Mycobacterium marinum M TetR family transcriptional regulator YP_001849664.1 1640826 R 216594 CDS YP_001849665.1 183981374 6225607 1641695..1642720 1 NC_010612.1 hypothetical protein 1642720 6225607 MMAR_1351 Mycobacterium marinum M hypothetical protein YP_001849665.1 1641695 D 216594 CDS YP_001849666.1 183981375 6225608 1642892..1644073 1 NC_010612.1 The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; molybdopterin biosynthesis-like protein MoeZ 1644073 moeB1 6225608 moeB1 Mycobacterium marinum M molybdopterin biosynthesis-like protein MoeZ YP_001849666.1 1642892 D 216594 CDS YP_001849667.1 183981376 6225609 1644139..1644993 1 NC_010612.1 hypothetical protein 1644993 6225609 MMAR_1353 Mycobacterium marinum M hypothetical protein YP_001849667.1 1644139 D 216594 CDS YP_001849668.1 183981377 6225610 complement(1644990..1645298) 1 NC_010612.1 causes methylation of DNA; DNA-methyltransferase (modification methylase) 1645298 6225610 MMAR_1354 Mycobacterium marinum M DNA-methyltransferase (modification methylase) YP_001849668.1 1644990 R 216594 CDS YP_001849669.1 183981378 6225611 complement(1645301..1646086) 1 NC_010612.1 function unknown, presumed lipolytic enzyme involved in cellular metabolism; lipase LipV 1646086 lipV 6225611 lipV Mycobacterium marinum M lipase LipV YP_001849669.1 1645301 R 216594 CDS YP_001849670.1 183981379 6225612 complement(1646151..1646372) 1 NC_010612.1 hypothetical protein 1646372 6225612 MMAR_1356 Mycobacterium marinum M hypothetical protein YP_001849670.1 1646151 R 216594 CDS YP_001849671.1 183981380 6225613 1646542..1647384 1 NC_010612.1 hypothetical protein 1647384 6225613 MMAR_1357 Mycobacterium marinum M hypothetical protein YP_001849671.1 1646542 D 216594 CDS YP_001849672.1 183981381 6225614 1647530..1650703 1 NC_010612.1 has both ATPase and helicase activities; ATP-dependent DNA helicase 1650703 6225614 MMAR_1358 Mycobacterium marinum M ATP-dependent DNA helicase YP_001849672.1 1647530 D 216594 CDS YP_001849673.1 183981382 6225615 1650700..1654005 1 NC_010612.1 has both ATPase and helicase activities; ATP-dependent DNA helicase 1654005 6225615 MMAR_1359 Mycobacterium marinum M ATP-dependent DNA helicase YP_001849673.1 1650700 D 216594 CDS YP_001849674.1 183981383 6225616 1654067..1655137 1 NC_010612.1 thought to be involved in cation transport across the membrane; transmembrane cation transporter 1655137 6225616 MMAR_1360 Mycobacterium marinum M transmembrane cation transporter YP_001849674.1 1654067 D 216594 CDS YP_001849675.1 183981384 6225617 1655303..1656229 1 NC_010612.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 1656229 nudC 6225617 nudC Mycobacterium marinum M NADH pyrophosphatase YP_001849675.1 1655303 D 216594 CDS YP_001849676.1 183981385 6225618 complement(1656233..1656958) 1 NC_010612.1 lipoprotein LpqQ 1656958 lpqQ 6225618 lpqQ Mycobacterium marinum M lipoprotein LpqQ YP_001849676.1 1656233 R 216594 CDS YP_001849677.1 183981386 6225619 complement(1657143..1657397) 1 NC_010612.1 glutaredoxin protein 1657397 6225619 MMAR_1363 Mycobacterium marinum M glutaredoxin protein YP_001849677.1 1657143 R 216594 CDS YP_001849678.1 183981387 6225620 1657523..1659652 1 NC_010612.1 involved in nucleotide excision repair. has both ATPase and helicase activities. unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single- stranded region is present. involved in the postincision events of nucleotide excision repair and methyl-directed mismatch repair; ATP-dependent DNA helicase II UvrD2 1659652 uvrD2 6225620 uvrD2 Mycobacterium marinum M ATP-dependent DNA helicase II UvrD2 YP_001849678.1 1657523 D 216594 CDS YP_001849679.1 183981388 6225621 1660071..1660346 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein Whib-like WhiB7 1660346 whiB7 6225621 whiB7 Mycobacterium marinum M transcriptional regulatory protein Whib-like WhiB7 YP_001849679.1 1660071 D 216594 CDS YP_001849680.1 183981389 6225622 complement(1660449..1661792) 1 NC_010612.1 thought to be involved in active transport across the membrane. responsible for energy coupling to the transport system; ABC transporter ATP-binding protein 1661792 6225622 MMAR_1366 Mycobacterium marinum M ABC transporter ATP-binding protein YP_001849680.1 1660449 R 216594 CDS YP_001849681.1 183981390 6225623 1661984..1662157 1 NC_010612.1 hypothetical protein 1662157 6225623 MMAR_1367 Mycobacterium marinum M hypothetical protein YP_001849681.1 1661984 D 216594 CDS YP_001849682.1 183981391 6225624 complement(1662177..1663016) 1 NC_010612.1 hypothetical protein 1663016 6225624 MMAR_1368 Mycobacterium marinum M hypothetical protein YP_001849682.1 1662177 R 216594 CDS YP_001849683.1 183981392 6225625 complement(1663055..1664473) 1 NC_010612.1 hypothetical protein 1664473 6225625 MMAR_1369 Mycobacterium marinum M hypothetical protein YP_001849683.1 1663055 R 216594 CDS YP_001849684.1 183981393 6225626 1664552..1665574 1 NC_010612.1 serine protease 1665574 6225626 MMAR_1370 Mycobacterium marinum M serine protease YP_001849684.1 1664552 D 216594 CDS YP_001849685.1 183981394 6225627 1665696..1668683 1 NC_010612.1 hypothetical protein 1668683 6225627 MMAR_1371 Mycobacterium marinum M hypothetical protein YP_001849685.1 1665696 D 216594 CDS YP_001849686.1 183981395 6225628 complement(1668828..1669841) 1 NC_010612.1 hypothetical protein 1669841 6225628 MMAR_1372 Mycobacterium marinum M hypothetical protein YP_001849686.1 1668828 R 216594 CDS YP_001849687.1 183981396 6225630 1670408..1671964 1 NC_010612.1 transposition of ISMyma05; transposase for ISMyma05 1671964 6225630 MMAR_1373 Mycobacterium marinum M transposase for ISMyma05 YP_001849687.1 1670408 D 216594 CDS YP_001849688.1 183981397 6225631 1672268..1672642 1 NC_010612.1 function unknown, possible role in posttranslational modification, protein turnover, chaperonefunctions; FK-506 binding protein, peptidyl-prolyl cis- trans isomerase 1672642 6225631 MMAR_1374 Mycobacterium marinum M FK-506 binding protein, peptidyl-prolyl cis- trans isomerase YP_001849688.1 1672268 D 216594 CDS YP_001849689.1 183981398 6225632 1672942..1675245 1 NC_010612.1 thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]; arylsulfatase AtsD 1675245 atsD_1 6225632 atsD_1 Mycobacterium marinum M arylsulfatase AtsD YP_001849689.1 1672942 D 216594 CDS YP_001849690.1 183981399 6225633 1675358..1675813 1 NC_010612.1 hypothetical protein 1675813 6225633 MMAR_1376 Mycobacterium marinum M hypothetical protein YP_001849690.1 1675358 D 216594 CDS YP_001849691.1 183981400 6225634 1675810..1676742 1 NC_010612.1 hypothetical protein 1676742 6225634 MMAR_1377 Mycobacterium marinum M hypothetical protein YP_001849691.1 1675810 D 216594 CDS YP_001849692.1 183981401 6225635 complement(1676793..1678214) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 1678214 6225635 MMAR_1378 Mycobacterium marinum M transcriptional regulatory protein YP_001849692.1 1676793 R 216594 CDS YP_001849693.1 183981402 6225636 1678334..1679839 1 NC_010612.1 hypothetical protein 1679839 6225636 MMAR_1379 Mycobacterium marinum M hypothetical protein YP_001849693.1 1678334 D 216594 CDS YP_001849694.1 183981403 6225637 1679839..1680756 1 NC_010612.1 methylisocitrate lyase 2 1680756 6225637 MMAR_1380 Mycobacterium marinum M methylisocitrate lyase 2 YP_001849694.1 1679839 D 216594 CDS YP_001849695.1 183981404 6225638 1680753..1681886 1 NC_010612.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; citrate synthase 1681886 gltA1 6225638 gltA1 Mycobacterium marinum M citrate synthase YP_001849695.1 1680753 D 216594 CDS YP_001849696.1 183981405 6225639 1682286..1682765 1 NC_010612.1 hypothetical protein 1682765 6225639 MMAR_1382 Mycobacterium marinum M hypothetical protein YP_001849696.1 1682286 D 216594 CDS YP_001849697.1 183981406 6225640 1682865..1683128 1 NC_010612.1 hypothetical protein 1683128 6225640 MMAR_1383 Mycobacterium marinum M hypothetical protein YP_001849697.1 1682865 D 216594 CDS YP_001849698.1 183981407 6225641 1683199..1683933 1 NC_010612.1 hypothetical protein 1683933 6225641 MMAR_1384 Mycobacterium marinum M hypothetical protein YP_001849698.1 1683199 D 216594 CDS YP_001849699.1 183981408 6225642 1683982..1684359 1 NC_010612.1 hypothetical protein 1684359 6225642 MMAR_1385 Mycobacterium marinum M hypothetical protein YP_001849699.1 1683982 D 216594 CDS YP_001849700.1 183981409 6225643 1684429..1684833 1 NC_010612.1 hypothetical protein 1684833 6225643 MMAR_1386 Mycobacterium marinum M hypothetical protein YP_001849700.1 1684429 D 216594 CDS YP_001849701.1 183981410 6225644 complement(1684844..1686235) 1 NC_010612.1 possibly catalyzes the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)]; monoamine oxidase 1686235 6225644 MMAR_1387 Mycobacterium marinum M monoamine oxidase YP_001849701.1 1684844 R 216594 CDS YP_001849702.1 183981411 6225645 1686396..1687376 1 NC_010612.1 supposed involved in detoxification reactions; non-heme haloperoxidase Hpx 1687376 hpx 6225645 hpx Mycobacterium marinum M non-heme haloperoxidase Hpx YP_001849702.1 1686396 D 216594 CDS YP_001849703.1 183981412 6225646 complement(1687371..1688717) 1 NC_010612.1 may catalyze the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)]. may have important function in metabolism. supposed involved; flavin-containing monoamine oxidase AofH 1688717 aofH 6225646 aofH Mycobacterium marinum M flavin-containing monoamine oxidase AofH YP_001849703.1 1687371 R 216594 CDS YP_001849704.1 183981413 6225647 1688821..1689819 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 1689819 6225647 MMAR_1390 Mycobacterium marinum M oxidoreductase YP_001849704.1 1688821 D 216594 CDS YP_001849705.1 183981414 6225648 complement(1689881..1692475) 1 NC_010612.1 PE-PGRS family protein 1692475 6225648 MMAR_1391 Mycobacterium marinum M PE-PGRS family protein YP_001849705.1 1689881 R 216594 CDS YP_001849706.1 183981415 6225649 complement(1692629..1693753) 1 NC_010612.1 hypothetical protein 1693753 6225649 MMAR_1392 Mycobacterium marinum M hypothetical protein YP_001849706.1 1692629 R 216594 CDS YP_001849707.1 183981416 6225650 complement(1693753..1694889) 1 NC_010612.1 hypothetical protein 1694889 6225650 MMAR_1393 Mycobacterium marinum M hypothetical protein YP_001849707.1 1693753 R 216594 CDS YP_001849708.1 183981417 6225651 1694934..1695536 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 1695536 6225651 MMAR_1394 Mycobacterium marinum M TetR family transcriptional regulator YP_001849708.1 1694934 D 216594 CDS YP_001849709.1 183981418 6225652 1695533..1696399 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 1696399 6225652 MMAR_1395 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001849709.1 1695533 D 216594 CDS YP_001849710.1 183981419 6225653 complement(1696562..1697959) 1 NC_010612.1 transposition of ISMyma02; transposase for insertion sequence ISMyma02 1697959 6225653 MMAR_1396 Mycobacterium marinum M transposase for insertion sequence ISMyma02 YP_001849710.1 1696562 R 216594 CDS YP_001849711.1 183981420 6225654 1698199..1699179 1 NC_010612.1 hypothetical protein 1699179 6225654 MMAR_1397 Mycobacterium marinum M hypothetical protein YP_001849711.1 1698199 D 216594 CDS YP_001849712.1 183981421 6225655 1699176..1699658 1 NC_010612.1 hypothetical protein 1699658 6225655 MMAR_1398 Mycobacterium marinum M hypothetical protein YP_001849712.1 1699176 D 216594 CDS YP_001849713.1 183981422 6225656 1699707..1700675 1 NC_010612.1 involved in transcriptional mechanism; regulates methanol dehydrogenase; methanol dehydrogenase transcriptional regulatory protein MoxR3 1700675 moxR3 6225656 moxR3 Mycobacterium marinum M methanol dehydrogenase transcriptional regulatory protein MoxR3 YP_001849713.1 1699707 D 216594 CDS YP_001849714.1 183981423 6225657 1700689..1701966 1 NC_010612.1 hypothetical protein 1701966 6225657 MMAR_1400 Mycobacterium marinum M hypothetical protein YP_001849714.1 1700689 D 216594 CDS YP_001849715.1 183981424 6225658 1701968..1702417 1 NC_010612.1 hypothetical protein 1702417 6225658 MMAR_1401 Mycobacterium marinum M hypothetical protein YP_001849715.1 1701968 D 216594 CDS YP_001849716.1 183981425 6225659 1702638..1704536 1 NC_010612.1 PPE family protein 1704536 6225659 MMAR_1402 Mycobacterium marinum M PPE family protein YP_001849716.1 1702638 D 216594 CDS YP_001849717.1 183981426 6225660 complement(1704699..1706096) 1 NC_010612.1 transposition of ISMyma02; transposase for insertion sequence ISMyma02 1706096 6225660 MMAR_1403 Mycobacterium marinum M transposase for insertion sequence ISMyma02 YP_001849717.1 1704699 R 216594 CDS YP_001849718.1 183981427 6225661 1706265..1706870 1 NC_010612.1 phage excisionase 1706870 6225661 MMAR_1404 Mycobacterium marinum M phage excisionase YP_001849718.1 1706265 D 216594 CDS YP_001849719.1 183981428 6225662 complement(1707278..1709542) 1 NC_010612.1 hypothetical protein 1709542 6225662 MMAR_1405 Mycobacterium marinum M hypothetical protein YP_001849719.1 1707278 R 216594 CDS YP_001849720.1 183981429 6225663 complement(1709558..1710190) 1 NC_010612.1 hypothetical protein 1710190 6225663 MMAR_1406 Mycobacterium marinum M hypothetical protein YP_001849720.1 1709558 R 216594 CDS YP_001849721.1 183981430 6225664 1710411..1711808 1 NC_010612.1 transposition of ISMyma02; transposase for insertion sequence ISMyma02 1711808 6225664 MMAR_1407 Mycobacterium marinum M transposase for insertion sequence ISMyma02 YP_001849721.1 1710411 D 216594 CDS YP_001849722.1 183981431 6225665 1712688..1713011 1 NC_010612.1 transposition of ISMyma03; transposase, ISMyma03_aa1 1713011 6225665 MMAR_5541 Mycobacterium marinum M transposase, ISMyma03_aa1 YP_001849722.1 1712688 D 216594 CDS YP_001849723.1 183981432 6225666 1713098..1713961 1 NC_010612.1 transposition of ISMyma03; transposase, ISMyma03_aa2 1713961 6225666 MMAR_1408 Mycobacterium marinum M transposase, ISMyma03_aa2 YP_001849723.1 1713098 D 216594 CDS YP_001849724.1 183981433 6225667 complement(1714422..1715423) 1 NC_010612.1 hypothetical protein 1715423 6225667 MMAR_1409 Mycobacterium marinum M hypothetical protein YP_001849724.1 1714422 R 216594 CDS YP_001849725.1 183981434 6225668 1715747..1716247 1 NC_010612.1 hypothetical protein 1716247 6225668 MMAR_1410 Mycobacterium marinum M hypothetical protein YP_001849725.1 1715747 D 216594 CDS YP_001849726.1 183981435 6225669 1716366..1718303 1 NC_010612.1 hypothetical protein 1718303 6225669 MMAR_1411 Mycobacterium marinum M hypothetical protein YP_001849726.1 1716366 D 216594 CDS YP_001849727.1 183981436 6225670 complement(1718685..1718933) 1 NC_010612.1 hypothetical protein 1718933 6225670 MMAR_1412 Mycobacterium marinum M hypothetical protein YP_001849727.1 1718685 R 216594 CDS YP_001849728.1 183981437 6225671 complement(1719456..1720061) 1 NC_010612.1 putative transcriptional regulatory protein 1720061 6225671 MMAR_1413 Mycobacterium marinum M putative transcriptional regulatory protein YP_001849728.1 1719456 R 216594 CDS YP_001849729.1 183981438 6225672 1720082..1720810 1 NC_010612.1 possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]; adenylate cyclase CyaA 1720810 cyaA_1 6225672 cyaA_1 Mycobacterium marinum M adenylate cyclase CyaA YP_001849729.1 1720082 D 216594 CDS YP_001849730.1 183981439 6225673 1720827..1721420 1 NC_010612.1 function unknown. contains a SAM-dependent methyltransferase domain; hypothetical protein 1721420 6225673 MMAR_1415 Mycobacterium marinum M hypothetical protein YP_001849730.1 1720827 D 216594 CDS YP_001849731.1 183981440 6225674 1722137..1723720 1 NC_010612.1 PPE family protein 1723720 6225674 MMAR_1418 Mycobacterium marinum M PPE family protein YP_001849731.1 1722137 D 216594 CDS YP_001849732.1 183981441 6225675 complement(1724188..1724814) 1 NC_010612.1 hypothetical protein 1724814 6225675 MMAR_1419 Mycobacterium marinum M hypothetical protein YP_001849732.1 1724188 R 216594 CDS YP_001849733.1 183981442 6225676 complement(1725443..1726279) 1 NC_010612.1 function unknown; domain identity to carbonic anhydrases. these are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide; carbonic anhydrase, CynT 1726279 cynT 6225676 cynT Mycobacterium marinum M carbonic anhydrase, CynT YP_001849733.1 1725443 R 216594 CDS YP_001849734.1 183981443 6225677 complement(1726843..1727103) 1 NC_010612.1 Single copy element; transposase for insertion sequence 1727103 6225677 MMAR_1421 Mycobacterium marinum M transposase for insertion sequence YP_001849734.1 1726843 R 216594 CDS YP_001849735.1 183981444 6225678 complement(1727691..1727960) 1 NC_010612.1 hypothetical protein 1727960 6225678 MMAR_1422 Mycobacterium marinum M hypothetical protein YP_001849735.1 1727691 R 216594 CDS YP_001849736.1 183981445 6225679 complement(1727983..1729908) 1 NC_010612.1 involved in signal transduction (via phosphorylation). catalytic activity: ATP + a protein = ADP + a phosphoprotein]; anchored-membrane serine/threonine-protein kinase 1729908 6225679 MMAR_1423 Mycobacterium marinum M anchored-membrane serine/threonine-protein kinase YP_001849736.1 1727983 R 216594 CDS YP_001849737.1 183981446 6225680 complement(1730132..1730266) 1 NC_010612.1 hypothetical protein 1730266 6225680 MMAR_1424 Mycobacterium marinum M hypothetical protein YP_001849737.1 1730132 R 216594 CDS YP_001849738.1 183981447 6225681 complement(1730263..1730451) 1 NC_010612.1 single copy element; transposase for insertion sequence 1730451 6225681 MMAR_1425 Mycobacterium marinum M transposase for insertion sequence YP_001849738.1 1730263 R 216594 CDS YP_001849739.1 183981448 6225682 complement(1730701..1731111) 1 NC_010612.1 hypothetical protein 1731111 6225682 MMAR_1426 Mycobacterium marinum M hypothetical protein YP_001849739.1 1730701 R 216594 CDS YP_001849740.1 183981449 6225683 1731589..1731864 1 NC_010612.1 hypothetical protein 1731864 6225683 MMAR_1427 Mycobacterium marinum M hypothetical protein YP_001849740.1 1731589 D 216594 CDS YP_001849741.1 183981450 6225684 1732032..1732403 1 NC_010612.1 hypothetical protein 1732403 6225684 MMAR_1428 Mycobacterium marinum M hypothetical protein YP_001849741.1 1732032 D 216594 CDS YP_001849742.1 183981451 6225685 1732539..1732916 1 NC_010612.1 function unknown, contains a N-term cation transport ATPase domain; hypothetical protein 1732916 6225685 MMAR_1429 Mycobacterium marinum M hypothetical protein YP_001849742.1 1732539 D 216594 CDS YP_001849743.1 183981452 6225686 1733014..1733310 1 NC_010612.1 hypothetical protein 1733310 6225686 MMAR_1430 Mycobacterium marinum M hypothetical protein YP_001849743.1 1733014 D 216594 CDS YP_001849744.1 183981453 6225687 1733300..1735738 1 NC_010612.1 metal cation-transporting ATPase; possibly catalyzes the transport of zinc with hydrolysis of ATP [catalytic activity: ATP + H(2)O + zinc (in) = ADP + phosphate + zinc (out)]; cation transport ATPase, ZntA 1735738 zntA 6225687 zntA Mycobacterium marinum M cation transport ATPase, ZntA YP_001849744.1 1733300 D 216594 CDS YP_001849745.1 183981454 6225688 1735803..1736435 1 NC_010612.1 hypothetical protein 1736435 6225688 MMAR_1432 Mycobacterium marinum M hypothetical protein YP_001849745.1 1735803 D 216594 CDS YP_001849746.1 183981455 6225689 1736726..1737805 1 NC_010612.1 domain identity with XerD and XerC integrases, DNA breaking-rejoining enzymes, n- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid inheritance; site-specific integrase 1737805 6225689 MMAR_1433 Mycobacterium marinum M site-specific integrase YP_001849746.1 1736726 D 216594 CDS YP_001849747.1 183981456 6225693 1742483..1744687 1 NC_010612.1 hypothetical protein 1744687 6225693 MMAR_1438 Mycobacterium marinum M hypothetical protein YP_001849747.1 1742483 D 216594 CDS YP_001849748.1 183981457 6225694 1744684..1745142 1 NC_010612.1 hypothetical protein 1745142 6225694 MMAR_1439 Mycobacterium marinum M hypothetical protein YP_001849748.1 1744684 D 216594 CDS YP_001849749.1 183981458 6225695 complement(1745104..1746210) 1 NC_010612.1 Single copy element. there are 24 copies of this element in M. smegmatis MC2155; ISL3 family transposase 1746210 6225695 MMAR_1440 Mycobacterium marinum M ISL3 family transposase YP_001849749.1 1745104 R 216594 CDS YP_001849750.1 183981459 6225696 complement(1746393..1746794) 1 NC_010612.1 hypothetical protein 1746794 6225696 MMAR_1441 Mycobacterium marinum M hypothetical protein YP_001849750.1 1746393 R 216594 CDS YP_001849751.1 183981460 6225697 complement(1746835..1751286) 1 NC_010612.1 PE-PGRS family protein 1751286 6225697 MMAR_1442 Mycobacterium marinum M PE-PGRS family protein YP_001849751.1 1746835 R 216594 CDS YP_001849752.1 183981461 6225698 complement(1751533..1752945) 1 NC_010612.1 high domain identity with a protein kinase; hypothetical protein 1752945 6225698 MMAR_1443 Mycobacterium marinum M hypothetical protein YP_001849752.1 1751533 R 216594 CDS YP_001849753.1 183981462 6225699 1753034..1753636 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 1753636 6225699 MMAR_1444 Mycobacterium marinum M TetR family transcriptional regulator YP_001849753.1 1753034 D 216594 CDS YP_001849754.1 183981463 6225700 1753983..1755380 1 NC_010612.1 transposition of insertion sequence ISMyma02; transposase for insertion sequence ISMyma02 1755380 6225700 MMAR_1445 Mycobacterium marinum M transposase for insertion sequence ISMyma02 YP_001849754.1 1753983 D 216594 CDS YP_001849755.1 183981464 6225701 complement(1756135..1756425) 1 NC_010612.1 hypothetical protein 1756425 6225701 MMAR_1447 Mycobacterium marinum M hypothetical protein YP_001849755.1 1756135 R 216594 CDS YP_001849756.1 183981465 6225702 complement(1756710..1759259) 1 NC_010612.1 metal cation-transporting ATPase; possibly catalyzes the transport of zinc metal cations with hydrolysis of ATP [catalytic activity: ATP + H(2)O + zinc metal cations (in) = ADP + phosphate + zinc metal cations (out)]; zinc cation transport ATPase 1759259 6225702 MMAR_1448 Mycobacterium marinum M zinc cation transport ATPase YP_001849756.1 1756710 R 216594 CDS YP_001849757.1 183981466 6225703 1760219..1761469 1 NC_010612.1 function unknown; PPE family protein 1761469 6225703 MMAR_1449 Mycobacterium marinum M PPE family protein YP_001849757.1 1760219 D 216594 CDS YP_001849758.1 183981467 6225704 complement(1761658..1761885) 1 NC_010612.1 hypothetical protein 1761885 6225704 MMAR_1450 Mycobacterium marinum M hypothetical protein YP_001849758.1 1761658 R 216594 CDS YP_001849759.1 183981468 6225706 complement(1762950..1764155) 1 NC_010612.1 transposition of ISMyma02; transposase for insertion sequence ISMyma02 1764155 6225706 MMAR_5540 Mycobacterium marinum M transposase for insertion sequence ISMyma02 YP_001849759.1 1762950 R 216594 CDS YP_001849760.1 183981469 6225708 complement(1764630..1765424) 1 NC_010612.1 transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa2 1765424 6225708 MMAR_1452 Mycobacterium marinum M transposase, ISMyma01_aa2 YP_001849760.1 1764630 R 216594 CDS YP_001849761.1 183981470 6225709 complement(1765466..1765747) 1 NC_010612.1 transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa1 1765747 6225709 MMAR_1453 Mycobacterium marinum M transposase, ISMyma01_aa1 YP_001849761.1 1765466 R 216594 CDS YP_001849762.1 183981471 6225710 complement(1766091..1766363) 1 NC_010612.1 hypothetical protein 1766363 6225710 MMAR_1454 Mycobacterium marinum M hypothetical protein YP_001849762.1 1766091 R 216594 CDS YP_001849763.1 183981472 6225711 complement(1766409..1767272) 1 NC_010612.1 transposition of ISMyma03; transposase, ISMyma03_aa2 1767272 6225711 MMAR_1455 Mycobacterium marinum M transposase, ISMyma03_aa2 YP_001849763.1 1766409 R 216594 CDS YP_001849764.1 183981473 6225712 complement(1767359..1767682) 1 NC_010612.1 transposition of ISMyma03; transposase, ISMyma03_aa1 1767682 6225712 MMAR_1456 Mycobacterium marinum M transposase, ISMyma03_aa1 YP_001849764.1 1767359 R 216594 CDS YP_001849765.1 183981474 6225713 complement(1767760..1767990) 1 NC_010612.1 hypothetical protein 1767990 6225713 MMAR_1457 Mycobacterium marinum M hypothetical protein YP_001849765.1 1767760 R 216594 CDS YP_001849766.1 183981475 6225714 complement(1768000..1768362) 1 NC_010612.1 hypothetical protein 1768362 6225714 MMAR_1458 Mycobacterium marinum M hypothetical protein YP_001849766.1 1768000 R 216594 CDS YP_001849767.1 183981476 6225715 complement(1768607..1769002) 1 NC_010612.1 hypothetical protein 1769002 6225715 MMAR_1459 Mycobacterium marinum M hypothetical protein YP_001849767.1 1768607 R 216594 CDS YP_001849768.1 183981477 6225716 complement(1769131..1770540) 1 NC_010612.1 PPE family protein 1770540 6225716 MMAR_1460 Mycobacterium marinum M PPE family protein YP_001849768.1 1769131 R 216594 CDS YP_001849769.1 183981478 6225717 complement(1770620..1771903) 1 NC_010612.1 PPE family protein 1771903 6225717 MMAR_1461 Mycobacterium marinum M PPE family protein YP_001849769.1 1770620 R 216594 CDS YP_001849770.1 183981479 6225718 complement(1772056..1773156) 1 NC_010612.1 oxidoreductase 1773156 6225718 MMAR_1462 Mycobacterium marinum M oxidoreductase YP_001849770.1 1772056 R 216594 CDS YP_001849771.1 183981480 6225719 complement(1773520..1773939) 1 NC_010612.1 hypothetical protein 1773939 6225719 MMAR_1464 Mycobacterium marinum M hypothetical protein YP_001849771.1 1773520 R 216594 CDS YP_001849772.1 183981481 6225720 1774244..1774648 1 NC_010612.1 hypothetical protein 1774648 6225720 MMAR_1465 Mycobacterium marinum M hypothetical protein YP_001849772.1 1774244 D 216594 CDS YP_001849773.1 183981482 6225721 complement(1774896..1775843) 1 NC_010612.1 Single copy element; transposition of an insertion sequence; transposase 1775843 6225721 MMAR_1466 Mycobacterium marinum M transposase YP_001849773.1 1774896 R 216594 CDS YP_001849774.1 183981483 6225723 complement(1777194..1778591) 1 NC_010612.1 transposition of the insertion sequence ISMyma02; transposase for insertion sequence ISMyma02 1778591 6225723 MMAR_1468 Mycobacterium marinum M transposase for insertion sequence ISMyma02 YP_001849774.1 1777194 R 216594 CDS YP_001849775.1 183981484 6225724 1779568..1781451 1 NC_010612.1 PPE family protein 1781451 6225724 MMAR_1469 Mycobacterium marinum M PPE family protein YP_001849775.1 1779568 D 216594 CDS YP_001849776.1 183981485 6225725 complement(1781510..1783096) 1 NC_010612.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 1783096 nuoN 6225725 nuoN Mycobacterium marinum M NADH dehydrogenase subunit N YP_001849776.1 1781510 R 216594 CDS YP_001849777.1 183981486 6225726 complement(1783093..1784679) 1 NC_010612.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 1784679 nuoM 6225726 nuoM Mycobacterium marinum M NADH dehydrogenase subunit M YP_001849777.1 1783093 R 216594 CDS YP_001849778.1 183981487 6225727 complement(1784676..1786577) 1 NC_010612.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 1786577 nuoL 6225727 nuoL Mycobacterium marinum M NADH dehydrogenase subunit L YP_001849778.1 1784676 R 216594 CDS YP_001849779.1 183981488 6225728 complement(1786588..1786887) 1 NC_010612.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 1786887 nuoK 6225728 nuoK Mycobacterium marinum M NADH dehydrogenase subunit K YP_001849779.1 1786588 R 216594 CDS YP_001849780.1 183981489 6225729 complement(1786884..1787672) 1 NC_010612.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 1787672 nuoJ 6225729 nuoJ Mycobacterium marinum M NADH dehydrogenase subunit J YP_001849780.1 1786884 R 216594 CDS YP_001849781.1 183981490 6225730 complement(1787669..1788214) 1 NC_010612.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 1788214 nuoI 6225730 nuoI Mycobacterium marinum M NADH dehydrogenase subunit I YP_001849781.1 1787669 R 216594 CDS YP_001849782.1 183981491 6225731 complement(1788207..1789481) 1 NC_010612.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 1789481 nuoH 6225731 nuoH Mycobacterium marinum M NADH dehydrogenase subunit H YP_001849782.1 1788207 R 216594 CDS YP_001849783.1 183981492 6225732 complement(1789531..1791948) 1 NC_010612.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 1791948 nuoG 6225732 nuoG Mycobacterium marinum M NADH dehydrogenase subunit G YP_001849783.1 1789531 R 216594 CDS YP_001849784.1 183981493 6225733 complement(1791945..1793291) 1 NC_010612.1 involved in aerobic|anaerobic respiration [catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol]; NADH dehydrogenase I subunit F 1793291 nuoF 6225733 nuoF Mycobacterium marinum M NADH dehydrogenase I subunit F YP_001849784.1 1791945 R 216594 CDS YP_001849785.1 183981494 6225734 complement(1793291..1794046) 1 NC_010612.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 1794046 nuoE 6225734 nuoE Mycobacterium marinum M NADH dehydrogenase subunit E YP_001849785.1 1793291 R 216594 CDS YP_001849786.1 183981495 6225735 complement(1794043..1795341) 1 NC_010612.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 1795341 nuoD 6225735 nuoD Mycobacterium marinum M NADH dehydrogenase subunit D YP_001849786.1 1794043 R 216594 CDS YP_001849787.1 183981496 6225736 complement(1795361..1796077) 1 NC_010612.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C 1796077 nuoC 6225736 nuoC Mycobacterium marinum M NADH dehydrogenase subunit C YP_001849787.1 1795361 R 216594 CDS YP_001849788.1 183981497 6225737 complement(1796074..1796628) 1 NC_010612.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 1796628 nuoB 6225737 nuoB Mycobacterium marinum M NADH dehydrogenase subunit B YP_001849788.1 1796074 R 216594 CDS YP_001849789.1 183981498 6225738 complement(1796637..1797125) 1 NC_010612.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 1797125 nuoA 6225738 nuoA Mycobacterium marinum M NADH dehydrogenase subunit A YP_001849789.1 1796637 R 216594 CDS YP_001849790.1 183981499 6225739 1797440..1798780 1 NC_010612.1 PPE family protein 1798780 6225739 MMAR_1484 Mycobacterium marinum M PPE family protein YP_001849790.1 1797440 D 216594 CDS YP_001849791.1 183981500 6225740 1798962..1800548 1 NC_010612.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB 1800548 plcB_2 6225740 plcB_2 Mycobacterium marinum M membrane-associated phospholipase C2 PlcB YP_001849791.1 1798962 D 216594 CDS YP_001849792.1 183981501 6225741 complement(1800585..1801034) 1 NC_010612.1 two-component system response regulator 1801034 6225741 MMAR_1486 Mycobacterium marinum M two-component system response regulator YP_001849792.1 1800585 R 216594 CDS YP_001849793.1 183981502 6225742 complement(1801061..1801600) 1 NC_010612.1 hypothetical protein 1801600 6225742 MMAR_1487 Mycobacterium marinum M hypothetical protein YP_001849793.1 1801061 R 216594 CDS YP_001849794.1 183981503 6225743 complement(1801636..1802046) 1 NC_010612.1 hypothetical protein 1802046 6225743 MMAR_1488 Mycobacterium marinum M hypothetical protein YP_001849794.1 1801636 R 216594 CDS YP_001849795.1 183981504 6225744 complement(1802058..1802399) 1 NC_010612.1 hypothetical protein 1802399 6225744 MMAR_1489 Mycobacterium marinum M hypothetical protein YP_001849795.1 1802058 R 216594 CDS YP_001849796.1 183981505 6225745 complement(1802399..1803361) 1 NC_010612.1 hypothetical protein 1803361 6225745 MMAR_1490 Mycobacterium marinum M hypothetical protein YP_001849796.1 1802399 R 216594 CDS YP_001849797.1 183981506 6225746 complement(1803358..1804596) 1 NC_010612.1 involved in lipid degradation; acyl-CoA dehydrogenase FadE12 1804596 fadE12_3 6225746 fadE12_3 Mycobacterium marinum M acyl-CoA dehydrogenase FadE12 YP_001849797.1 1803358 R 216594 CDS YP_001849798.1 183981507 6225747 complement(1804621..1805262) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 1805262 6225747 MMAR_1492 Mycobacterium marinum M transcriptional regulatory protein YP_001849798.1 1804621 R 216594 CDS YP_001849799.1 183981508 6225748 complement(1805262..1806158) 1 NC_010612.1 hypothetical protein 1806158 6225748 MMAR_1493 Mycobacterium marinum M hypothetical protein YP_001849799.1 1805262 R 216594 CDS YP_001849800.1 183981509 6225749 complement(1806155..1807360) 1 NC_010612.1 hypothetical protein 1807360 6225749 MMAR_1494 Mycobacterium marinum M hypothetical protein YP_001849800.1 1806155 R 216594 CDS YP_001849801.1 183981510 6225750 complement(1807357..1808547) 1 NC_010612.1 hypothetical protein 1808547 6225750 MMAR_1495 Mycobacterium marinum M hypothetical protein YP_001849801.1 1807357 R 216594 CDS YP_001849802.1 183981511 6225751 complement(1808550..1809653) 1 NC_010612.1 oxidoreductase 1809653 6225751 MMAR_1496 Mycobacterium marinum M oxidoreductase YP_001849802.1 1808550 R 216594 CDS YP_001849803.1 183981512 6225752 1809969..1811951 1 NC_010612.1 PPE family protein 1811951 6225752 MMAR_1497 Mycobacterium marinum M PPE family protein YP_001849803.1 1809969 D 216594 CDS YP_001849804.1 183981513 6225753 complement(1811969..1812940) 1 NC_010612.1 involved in lipid degradation [catalytic activity: NADPH + quinone = NADP(+) + semiquinone]; NADPH quinone oxidoreductase FadB4 1812940 fadB4 6225753 fadB4 Mycobacterium marinum M NADPH quinone oxidoreductase FadB4 YP_001849804.1 1811969 R 216594 CDS YP_001849805.1 183981514 6225754 complement(1812983..1813981) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 1813981 6225754 MMAR_1499 Mycobacterium marinum M oxidoreductase YP_001849805.1 1812983 R 216594 CDS YP_001849806.1 183981515 6225755 complement(1814049..1815083) 1 NC_010612.1 hypothetical protein 1815083 6225755 MMAR_1500 Mycobacterium marinum M hypothetical protein YP_001849806.1 1814049 R 216594 CDS YP_001849807.1 183981516 6225756 complement(1815053..1816093) 1 NC_010612.1 function unknown, C-term identity with glyoxalase domains; hypothetical protein 1816093 6225756 MMAR_1501 Mycobacterium marinum M hypothetical protein YP_001849807.1 1815053 R 216594 CDS YP_001849808.1 183981517 6225757 complement(1816090..1816953) 1 NC_010612.1 function unknown, N-term has esterase domain identity; hypothetical protein 1816953 6225757 MMAR_1502 Mycobacterium marinum M hypothetical protein YP_001849808.1 1816090 R 216594 CDS YP_001849809.1 183981518 6225758 complement(1816950..1818563) 1 NC_010612.1 function unknown role in energy production/conversion; FAD-dependent oxidoreductase 1818563 6225758 MMAR_1503 Mycobacterium marinum M FAD-dependent oxidoreductase YP_001849809.1 1816950 R 216594 CDS YP_001849810.1 183981519 6225759 1818671..1819339 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 1819339 6225759 MMAR_1504 Mycobacterium marinum M transcriptional regulatory protein YP_001849810.1 1818671 D 216594 CDS YP_001849811.1 183981520 6225760 1819336..1820346 1 NC_010612.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 1820346 mhpF 6225760 mhpF Mycobacterium marinum M acetaldehyde dehydrogenase YP_001849811.1 1819336 D 216594 CDS YP_001849812.1 183981521 6225761 1820343..1821377 1 NC_010612.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 1821377 6225761 MMAR_1506 Mycobacterium marinum M 4-hydroxy-2-ketovalerate aldolase YP_001849812.1 1820343 D 216594 CDS YP_001849813.1 183981522 6225762 1821426..1822202 1 NC_010612.1 function unknown, possible role secondary metabolite biosynthesis; alpha-acetolactate decarboxylase 1822202 6225762 MMAR_1507 Mycobacterium marinum M alpha-acetolactate decarboxylase YP_001849813.1 1821426 D 216594 CDS YP_001849814.1 183981523 6225763 1822205..1823875 1 NC_010612.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase; acetolactate synthase 1823875 ilvB1_1 6225763 ilvB1_1 Mycobacterium marinum M acetolactate synthase YP_001849814.1 1822205 D 216594 CDS YP_001849815.1 183981524 6225764 complement(1823885..1825090) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE23 1825090 fadE23 6225764 fadE23 Mycobacterium marinum M acyl-CoA dehydrogenase FadE23 YP_001849815.1 1823885 R 216594 CDS YP_001849816.1 183981525 6225765 complement(1825145..1826542) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE24 1826542 fadE24 6225765 fadE24 Mycobacterium marinum M acyl-CoA dehydrogenase FadE24 YP_001849816.1 1825145 R 216594 CDS YP_001849817.1 183981526 6225766 complement(1826624..1827412) 1 NC_010612.1 function unknown, involved in cellular metabolism; monophosphatase 1827412 6225766 MMAR_1511 Mycobacterium marinum M monophosphatase YP_001849817.1 1826624 R 216594 CDS YP_001849818.1 183981527 6225767 1827436..1827771 1 NC_010612.1 hypothetical protein 1827771 6225767 MMAR_1512 Mycobacterium marinum M hypothetical protein YP_001849818.1 1827436 D 216594 CDS YP_001849819.1 183981528 6225768 complement(1827790..1828938) 1 NC_010612.1 PPE family protein 1828938 6225768 MMAR_1513 Mycobacterium marinum M PPE family protein YP_001849819.1 1827790 R 216594 CDS YP_001849820.1 183981529 6225769 complement(1829479..1830624) 1 NC_010612.1 PPE family protein 1830624 6225769 MMAR_1514 Mycobacterium marinum M PPE family protein YP_001849820.1 1829479 R 216594 CDS YP_001849821.1 183981530 6225770 1831562..1832356 1 NC_010612.1 may play a role in the adaptation to hypoxia, participating in the phosphorelay in the two-component regulatory system DevR/DevS; hypothetical protein 1832356 6225770 MMAR_1515 Mycobacterium marinum M hypothetical protein YP_001849821.1 1831562 D 216594 CDS YP_001849822.1 183981531 6225771 1832380..1833030 1 NC_010612.1 regulator part of the two-component regulatory system DevR/DevS. controls HspX|Acr expression; two-component transcriptional regulatory protein DevR 1833030 devR 6225771 devR Mycobacterium marinum M two-component transcriptional regulatory protein DevR YP_001849822.1 1832380 D 216594 CDS YP_001849823.1 183981532 6225772 1833042..1834799 1 NC_010612.1 sensor part of the two-component regulatory system DevR/DevS. thought to control HspX|Acr expression; two-component sensor histidine kinase DevS 1834799 devS 6225772 devS Mycobacterium marinum M two-component sensor histidine kinase DevS YP_001849823.1 1833042 D 216594 CDS YP_001849824.1 183981533 6225773 complement(1834779..1835777) 1 NC_010612.1 hypothetical protein 1835777 6225773 MMAR_1518 Mycobacterium marinum M hypothetical protein YP_001849824.1 1834779 R 216594 CDS YP_001849825.1 183981534 6225774 1835969..1837357 1 NC_010612.1 hypothetical protein 1837357 6225774 MMAR_1519 Mycobacterium marinum M hypothetical protein YP_001849825.1 1835969 D 216594 CDS YP_001849826.1 183981535 6225775 1837360..1837776 1 NC_010612.1 hypothetical protein 1837776 6225775 MMAR_1520 Mycobacterium marinum M hypothetical protein YP_001849826.1 1837360 D 216594 CDS YP_001849827.1 183981536 6225776 complement(1837858..1838286) 1 NC_010612.1 hypothetical protein 1838286 6225776 MMAR_1521 Mycobacterium marinum M hypothetical protein YP_001849827.1 1837858 R 216594 CDS YP_001849828.1 183981537 6225777 complement(1838291..1839292) 1 NC_010612.1 hypothetical protein 1839292 6225777 MMAR_1522 Mycobacterium marinum M hypothetical protein YP_001849828.1 1838291 R 216594 CDS YP_001849829.1 183981538 6225778 1839444..1840817 1 NC_010612.1 hypothetical protein 1840817 6225778 MMAR_1523 Mycobacterium marinum M hypothetical protein YP_001849829.1 1839444 D 216594 CDS YP_001849830.1 183981539 6225779 1840846..1841049 1 NC_010612.1 hypothetical protein 1841049 6225779 MMAR_1524 Mycobacterium marinum M hypothetical protein YP_001849830.1 1840846 D 216594 CDS YP_001849831.1 183981540 6225780 1841059..1842651 1 NC_010612.1 involved in ether lipid biosynthesis [catalytic activity: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion]; alkyldihydroxyacetonephosphate synthase AgpS 1842651 agpS 6225780 agpS Mycobacterium marinum M alkyldihydroxyacetonephosphate synthase AgpS YP_001849831.1 1841059 D 216594 CDS YP_001849832.1 183981541 6225781 complement(1842652..1844022) 1 NC_010612.1 generates oxidized ferredoxin from ferredoxin [catalytic activity: reduced ferredoxin + NADP(+) = oxidized ferredoxin + NADPH]; NADPH:adrenodoxin oxidoreductase FprA 1844022 fprA_1 6225781 fprA_1 Mycobacterium marinum M NADPH:adrenodoxin oxidoreductase FprA YP_001849832.1 1842652 R 216594 CDS YP_001849833.1 183981542 6225782 1844156..1845271 1 NC_010612.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 1845271 prfB 6225782 prfB Mycobacterium marinum M peptide chain release factor 2 YP_001849833.1 1844156 D 216594 CDS YP_001849834.1 183981543 6225783 1845261..1846247 1 NC_010612.1 function unknown but contains mechanosensitive (ms) ion channel forming domain with a possible role in cell envelope biogenesis; transmembrane protein 1846247 6225783 MMAR_1528 Mycobacterium marinum M transmembrane protein YP_001849834.1 1845261 D 216594 CDS YP_001849835.1 183981544 6225784 1846250..1846750 1 NC_010612.1 function unknown: predicted solute binding protein; hypothetical protein 1846750 6225784 MMAR_1529 Mycobacterium marinum M hypothetical protein YP_001849835.1 1846250 D 216594 CDS YP_001849836.1 183981545 6225785 1846795..1847484 1 NC_010612.1 involved in growth. thought to be involved in active transport of septation component across the membrane. responsible for energy coupling to the transport system. coded for in an operon essential for cell division; cell division ATP-binding protein FtsE 1847484 ftsE 6225785 ftsE Mycobacterium marinum M cell division ATP-binding protein FtsE YP_001849836.1 1846795 D 216594 CDS YP_001849837.1 183981546 6225786 1847485..1848378 1 NC_010612.1 involved in growth (principally during log phase cells). thought to be involved in active transport of septation component across the membrane. responsible for the translocation of the substrate across the membrane. coded for in an operon essential for ce; cell division protein FtsX 1848378 ftsX 6225786 ftsX Mycobacterium marinum M cell division protein FtsX YP_001849837.1 1847485 D 216594 CDS YP_001849838.1 183981547 6225787 1848381..1848887 1 NC_010612.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1848887 smpB 6225787 smpB Mycobacterium marinum M SsrA-binding protein YP_001849838.1 1848381 D 216594 CDS YP_001849839.1 183981548 6225788 complement(1848921..1849787) 1 NC_010612.1 hypothetical protein 1849787 6225788 MMAR_1533 Mycobacterium marinum M hypothetical protein YP_001849839.1 1848921 R 216594 CDS YP_001849840.1 183981549 6225789 complement(1849784..1852123) 1 NC_010612.1 hypothetical protein 1852123 6225789 MMAR_1534 Mycobacterium marinum M hypothetical protein YP_001849840.1 1849784 R 216594 CDS YP_001849841.1 183981550 6225790 1852462..1853703 1 NC_010612.1 ATPase; possibly catalyzes the transport of undeterminated substrate with hydrolysis of ATP [catalytic activity: ATP + H(2)O + undeterminated substrate(in) = ADP + phosphate + undeterminated substrate(out)]; ATPase 1853703 6225790 MMAR_1535 Mycobacterium marinum M ATPase YP_001849841.1 1852462 D 216594 CDS YP_001849842.1 183981551 6225791 1853703..1854731 1 NC_010612.1 hypothetical protein 1854731 6225791 MMAR_1536 Mycobacterium marinum M hypothetical protein YP_001849842.1 1853703 D 216594 CDS YP_001849843.1 183981552 6225792 1854756..1855601 1 NC_010612.1 hypothetical protein 1855601 6225792 MMAR_1537 Mycobacterium marinum M hypothetical protein YP_001849843.1 1854756 D 216594 CDS YP_001849844.1 183981553 6225794 complement(1856202..1857965) 1 NC_010612.1 PE family protein 1857965 6225794 MMAR_1538 Mycobacterium marinum M PE family protein YP_001849844.1 1856202 R 216594 CDS YP_001849845.1 183981554 6225795 complement(1857969..1858196) 1 NC_010612.1 hypothetical protein 1858196 6225795 MMAR_1539 Mycobacterium marinum M hypothetical protein YP_001849845.1 1857969 R 216594 CDS YP_001849846.1 183981555 6225796 1858295..1858648 1 NC_010612.1 hypothetical protein 1858648 6225796 MMAR_5566 Mycobacterium marinum M hypothetical protein YP_001849846.1 1858295 D 216594 CDS YP_001849847.1 183981556 6225797 complement(1858688..1858951) 1 NC_010612.1 hypothetical protein 1858951 6225797 MMAR_1540 Mycobacterium marinum M hypothetical protein YP_001849847.1 1858688 R 216594 CDS YP_001849848.1 183981557 6225798 1859202..1859900 1 NC_010612.1 hypothetical protein 1859900 6225798 MMAR_1541 Mycobacterium marinum M hypothetical protein YP_001849848.1 1859202 D 216594 CDS YP_001849849.1 183981558 6225799 complement(1859944..1860810) 1 NC_010612.1 hypothetical protein 1860810 6225799 MMAR_1542 Mycobacterium marinum M hypothetical protein YP_001849849.1 1859944 R 216594 CDS YP_001849850.1 183981559 6225800 complement(1860877..1861563) 1 NC_010612.1 hypothetical protein 1861563 6225800 MMAR_1543 Mycobacterium marinum M hypothetical protein YP_001849850.1 1860877 R 216594 CDS YP_001849851.1 183981560 6225801 complement(1861606..1862223) 1 NC_010612.1 hypothetical protein 1862223 6225801 MMAR_1544 Mycobacterium marinum M hypothetical protein YP_001849851.1 1861606 R 216594 CDS YP_001849852.1 183981561 6225802 1862298..1863119 1 NC_010612.1 hypothetical protein 1863119 6225802 MMAR_1545 Mycobacterium marinum M hypothetical protein YP_001849852.1 1862298 D 216594 CDS YP_001849853.1 183981562 6225803 complement(1863166..1863687) 1 NC_010612.1 hypothetical protein 1863687 6225803 MMAR_1546 Mycobacterium marinum M hypothetical protein YP_001849853.1 1863166 R 216594 CDS YP_001849854.1 183981563 6225804 1864049..1865686 1 NC_010612.1 PE-PGRS family protein 1865686 6225804 MMAR_1547 Mycobacterium marinum M PE-PGRS family protein YP_001849854.1 1864049 D 216594 CDS YP_001849855.1 183981564 6225805 1865754..1866716 1 NC_010612.1 catalyzes the formation of glutamate from glutamine; glutaminase 1866716 glsA 6225805 glsA Mycobacterium marinum M glutaminase YP_001849855.1 1865754 D 216594 CDS YP_001849856.1 183981565 6225806 1866810..1867232 1 NC_010612.1 function unknown but has domain similarity to predicted flavin-nucleotide-binding proteins; hypothetical protein 1867232 6225806 MMAR_1549 Mycobacterium marinum M hypothetical protein YP_001849856.1 1866810 D 216594 CDS YP_001849857.1 183981566 6225807 complement(1867237..1869276) 1 NC_010612.1 PPE family protein 1869276 6225807 MMAR_1550 Mycobacterium marinum M PPE family protein YP_001849857.1 1867237 R 216594 CDS YP_001849858.1 183981567 6225808 complement(1869605..1870468) 1 NC_010612.1 contains a phytanoyl-CoA dioxygenase domain; hypothetical protein 1870468 6225808 MMAR_1551 Mycobacterium marinum M hypothetical protein YP_001849858.1 1869605 R 216594 CDS YP_001849859.1 183981568 6225809 1870609..1870923 1 NC_010612.1 hypothetical protein 1870923 6225809 MMAR_1552 Mycobacterium marinum M hypothetical protein YP_001849859.1 1870609 D 216594 CDS YP_001849860.1 183981569 6225810 1871130..1871618 1 NC_010612.1 hypothetical protein 1871618 6225810 MMAR_1553 Mycobacterium marinum M hypothetical protein YP_001849860.1 1871130 D 216594 CDS YP_001849861.1 183981570 6225811 complement(1871632..1872768) 1 NC_010612.1 hypothetical protein 1872768 6225811 MMAR_1554 Mycobacterium marinum M hypothetical protein YP_001849861.1 1871632 R 216594 CDS YP_001849862.1 183981571 6225812 complement(1873029..1873505) 1 NC_010612.1 transcriptional regulatory protein 1873505 6225812 MMAR_1555 Mycobacterium marinum M transcriptional regulatory protein YP_001849862.1 1873029 R 216594 CDS YP_001849863.1 183981572 6225813 1873585..1874745 1 NC_010612.1 dehydrogenase 1874745 6225813 MMAR_1556 Mycobacterium marinum M dehydrogenase YP_001849863.1 1873585 D 216594 CDS YP_001849864.1 183981573 6225814 1874742..1875719 1 NC_010612.1 oxidoreductase 1875719 6225814 MMAR_1557 Mycobacterium marinum M oxidoreductase YP_001849864.1 1874742 D 216594 CDS YP_001849865.1 183981574 6225815 1875716..1876723 1 NC_010612.1 NADP-dependent oxidoreductase 1876723 6225815 MMAR_1558 Mycobacterium marinum M NADP-dependent oxidoreductase YP_001849865.1 1875716 D 216594 CDS YP_001849866.1 183981575 6225816 complement(1876745..1878244) 1 NC_010612.1 hypothetical protein 1878244 6225816 MMAR_1559 Mycobacterium marinum M hypothetical protein YP_001849866.1 1876745 R 216594 CDS YP_001849867.1 183981576 6225817 complement(1878286..1879266) 1 NC_010612.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 1879266 6225817 MMAR_1560 Mycobacterium marinum M nucleoside triphosphate pyrophosphohydrolase YP_001849867.1 1878286 R 216594 CDS YP_001849868.1 183981577 6225818 complement(1879353..1880297) 1 NC_010612.1 catalyzes the first step in the biosynthesis of 2- methylthio-n6-(delta(2)-isopentenyl)-adenosine adjacent to the anticodon of several tRNA species [catalytic activity: isopentenyl diphosphate + tRNA = pyrophosphate + tRNA containing 6-isopentenyladenosine]; tRNA delta(2)-isopentenylpyrophosphate transferase MiaA 1880297 miaA_1 6225818 miaA_1 Mycobacterium marinum M tRNA delta(2)-isopentenylpyrophosphate transferase MiaA YP_001849868.1 1879353 R 216594 CDS YP_001849869.1 183981578 6225819 complement(1880466..1881233) 1 NC_010612.1 function unknown contains C-term of lysine decarboxylase domain; hypothetical protein 1881233 6225819 MMAR_1562 Mycobacterium marinum M hypothetical protein YP_001849869.1 1880466 R 216594 CDS YP_001849870.1 183981579 6225820 complement(1881230..1881691) 1 NC_010612.1 function unknown, contains domain identity with ring hydroxylating dioxygenase beta subunit. this subunit has a similar structure to NTF-2, ketosteroid isomerase and scytalone dehydratase.the degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the substrate by nonheme iron- containing dioxygenases; hypothetical protein 1881691 6225820 MMAR_1563 Mycobacterium marinum M hypothetical protein YP_001849870.1 1881230 R 216594 CDS YP_001849871.1 183981580 6225821 complement(1881688..1882923) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 276A1 Cyp276A1 1882923 cyp276A1 6225821 cyp276A1 Mycobacterium marinum M cytochrome P450 276A1 Cyp276A1 YP_001849871.1 1881688 R 216594 CDS YP_001849872.1 183981581 6225822 complement(1882994..1883767) 1 NC_010612.1 function unknown, possible role in methylation of unknown substrate; methyltransferase 1883767 6225822 MMAR_1565 Mycobacterium marinum M methyltransferase YP_001849872.1 1882994 R 216594 CDS YP_001849873.1 183981582 6225823 complement(1884059..1885648) 1 NC_010612.1 MiaB protein is involved in tRNA biogenesis. it is a bifunctional iron-sulphur enzyme, involved in both thiolation and methylation of isopentenyl-adenosine; 2-methylthioadenine synthetase 1885648 miaB 6225823 miaB Mycobacterium marinum M 2-methylthioadenine synthetase YP_001849873.1 1884059 R 216594 CDS YP_001849874.1 183981583 6225824 1886484..1887401 1 NC_010612.1 hypothetical protein 1887401 6225824 MMAR_1567 Mycobacterium marinum M hypothetical protein YP_001849874.1 1886484 D 216594 CDS YP_001849875.1 183981584 6225825 complement(1887418..1888221) 1 NC_010612.1 function unknown; possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 1888221 6225825 MMAR_1568 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001849875.1 1887418 R 216594 CDS YP_001849876.1 183981585 6225826 complement(1888254..1889021) 1 NC_010612.1 putative regulatory protein 1889021 6225826 MMAR_1569 Mycobacterium marinum M putative regulatory protein YP_001849876.1 1888254 R 216594 CDS YP_001849877.1 183981586 6225827 complement(1889075..1889719) 1 NC_010612.1 hypothetical protein 1889719 6225827 MMAR_1570 Mycobacterium marinum M hypothetical protein YP_001849877.1 1889075 R 216594 CDS YP_001849878.1 183981587 6225828 complement(1889770..1891461) 1 NC_010612.1 function unknown but shares esterase domain identity; hypothetical protein 1891461 6225828 MMAR_1571 Mycobacterium marinum M hypothetical protein YP_001849878.1 1889770 R 216594 CDS YP_001849879.1 183981588 6225829 complement(1891498..1892388) 1 NC_010612.1 function unknown, first 70 aa missing WRT to orthologues; hypothetical protein 1892388 6225829 MMAR_1572 Mycobacterium marinum M hypothetical protein YP_001849879.1 1891498 R 216594 CDS YP_001849880.1 183981589 6225830 complement(1892549..1894012) 1 NC_010612.1 hypothetical protein 1894012 6225830 MMAR_1573 Mycobacterium marinum M hypothetical protein YP_001849880.1 1892549 R 216594 CDS YP_001849881.1 183981590 6225831 1894092..1894490 1 NC_010612.1 hypothetical protein 1894490 6225831 MMAR_1574 Mycobacterium marinum M hypothetical protein YP_001849881.1 1894092 D 216594 CDS YP_001849882.1 183981591 6225832 1894499..1895326 1 NC_010612.1 oxidoreductase 1895326 6225832 MMAR_1575 Mycobacterium marinum M oxidoreductase YP_001849882.1 1894499 D 216594 CDS YP_001849883.1 183981592 6225833 1895536..1895922 1 NC_010612.1 hypothetical protein 1895922 6225833 MMAR_1576 Mycobacterium marinum M hypothetical protein YP_001849883.1 1895536 D 216594 CDS YP_001849884.1 183981593 6225834 complement(1895944..1897755) 1 NC_010612.1 function unknown but domain homology to arylsulfatase a ( AslA )and related enzymes; hydrolase 1897755 6225834 MMAR_1577 Mycobacterium marinum M hydrolase YP_001849884.1 1895944 R 216594 CDS YP_001849885.1 183981594 6225835 complement(1897748..1898167) 1 NC_010612.1 hypothetical protein 1898167 6225835 MMAR_1578 Mycobacterium marinum M hypothetical protein YP_001849885.1 1897748 R 216594 CDS YP_001849886.1 183981595 6225836 complement(1898311..1899984) 1 NC_010612.1 hypothetical protein 1899984 6225836 MMAR_1579 Mycobacterium marinum M hypothetical protein YP_001849886.1 1898311 R 216594 CDS YP_001849887.1 183981596 6225837 complement(1900048..1901472) 1 NC_010612.1 function unknown; probably involved in cellular metabolism; dehydrogenase 1901472 6225837 MMAR_1580 Mycobacterium marinum M dehydrogenase YP_001849887.1 1900048 R 216594 CDS YP_001849888.1 183981597 6225838 complement(1901469..1903286) 1 NC_010612.1 hypothetical protein 1903286 6225838 MMAR_1581 Mycobacterium marinum M hypothetical protein YP_001849888.1 1901469 R 216594 CDS YP_001849889.1 183981598 6225839 1903478..1904755 1 NC_010612.1 function unknown but domain identity suggests transcriptional regulator; hypothetical protein 1904755 6225839 MMAR_1582 Mycobacterium marinum M hypothetical protein YP_001849889.1 1903478 D 216594 CDS YP_001849890.1 183981599 6225840 1904846..1905781 1 NC_010612.1 interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate]; citrate lyase beta subunit, CitE_2 1905781 citE_2 6225840 citE_2 Mycobacterium marinum M citrate lyase beta subunit, CitE_2 YP_001849890.1 1904846 D 216594 CDS YP_001849891.1 183981600 6225841 complement(1905803..1907077) 1 NC_010612.1 function unknown; hypothetical protein 1907077 6225841 MMAR_1584 Mycobacterium marinum M hypothetical protein YP_001849891.1 1905803 R 216594 CDS YP_001849892.1 183981601 6225842 1907135..1907491 1 NC_010612.1 hypothetical protein 1907491 6225842 MMAR_1585 Mycobacterium marinum M hypothetical protein YP_001849892.1 1907135 D 216594 CDS YP_001849893.1 183981602 6225843 1907533..1908411 1 NC_010612.1 oxidoreductase 1908411 6225843 MMAR_1586 Mycobacterium marinum M oxidoreductase YP_001849893.1 1907533 D 216594 CDS YP_001849894.1 183981603 6225844 1908425..1909048 1 NC_010612.1 hypothetical protein 1909048 6225844 MMAR_1587 Mycobacterium marinum M hypothetical protein YP_001849894.1 1908425 D 216594 CDS YP_001849895.1 183981604 6225845 complement(1909059..1910165) 1 NC_010612.1 hypothetical protein 1910165 6225845 MMAR_1588 Mycobacterium marinum M hypothetical protein YP_001849895.1 1909059 R 216594 CDS YP_001849896.1 183981605 6225846 complement(1910162..1910536) 1 NC_010612.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1910536 6225846 MMAR_1589 Mycobacterium marinum M camphor resistance protein CrcB YP_001849896.1 1910162 R 216594 CDS YP_001849897.1 183981606 6225847 complement(1910536..1910931) 1 NC_010612.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1910931 6225847 MMAR_1590 Mycobacterium marinum M camphor resistance protein CrcB YP_001849897.1 1910536 R 216594 CDS YP_001849898.1 183981607 6225848 1911059..1912690 1 NC_010612.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 1912690 pgmA 6225848 pgmA Mycobacterium marinum M phosphoglucomutase YP_001849898.1 1911059 D 216594 CDS YP_001849899.1 183981608 6225850 1912943..1913212 1 NC_010612.1 hypothetical protein 1913212 6225850 MMAR_1592 Mycobacterium marinum M hypothetical protein YP_001849899.1 1912943 D 216594 CDS YP_001849900.1 183981609 6225852 complement(1918529..1929433) 1 NC_010612.1 PE-PGRS family protein 1929433 6225852 MMAR_1594 Mycobacterium marinum M PE-PGRS family protein YP_001849900.1 1918529 R 216594 CDS YP_001849901.1 183981610 6225853 1931701..1932657 1 NC_010612.1 secondary metabolites biosynthesis, transport, and catabolism; O-methyltransferase 1932657 6225853 MMAR_1595 Mycobacterium marinum M O-methyltransferase YP_001849901.1 1931701 D 216594 CDS YP_001849902.1 183981611 6225854 1932650..1933411 1 NC_010612.1 function unknown, contains a SAM-dependent methyltransferase domain; hypothetical protein 1933411 6225854 MMAR_1596 Mycobacterium marinum M hypothetical protein YP_001849902.1 1932650 D 216594 CDS YP_001849903.1 183981612 6225855 1933569..1934207 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 1934207 6225855 MMAR_1597 Mycobacterium marinum M transcriptional regulatory protein YP_001849903.1 1933569 D 216594 CDS YP_001849904.1 183981613 6225856 1934672..1934905 1 NC_010612.1 single copy element; transposition of an ISMyma01-like insertion sequence; transposase 1934905 6225856 MMAR_1598 Mycobacterium marinum M transposase YP_001849904.1 1934672 D 216594 CDS YP_001849905.1 183981614 6225857 1935049..1935738 1 NC_010612.1 single copy element; transposition of an ISMyma01-like element; transposase 1935738 6225857 MMAR_1599 Mycobacterium marinum M transposase YP_001849905.1 1935049 D 216594 CDS YP_001849906.1 183981615 6225858 1935870..1936259 1 NC_010612.1 hypothetical protein 1936259 6225858 MMAR_1600 Mycobacterium marinum M hypothetical protein YP_001849906.1 1935870 D 216594 CDS YP_001849907.1 183981616 6225859 complement(1936366..1936956) 1 NC_010612.1 PE-PGRS family protein 1936956 6225859 MMAR_1601 Mycobacterium marinum M PE-PGRS family protein YP_001849907.1 1936366 R 216594 CDS YP_001849908.1 183981617 6225860 1937328..1939301 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase GMC-type 1939301 6225860 MMAR_1602 Mycobacterium marinum M oxidoreductase GMC-type YP_001849908.1 1937328 D 216594 CDS YP_001849909.1 183981618 6225861 complement(1939337..1940602) 1 NC_010612.1 hypothetical protein 1940602 6225861 MMAR_1603 Mycobacterium marinum M hypothetical protein YP_001849909.1 1939337 R 216594 CDS YP_001849910.1 183981619 6225862 1940884..1941774 1 NC_010612.1 function unknown but contains Cdd pfam03982, DAGAT, diacylglycerol acyltransferase domain; hypothetical protein 1941774 6225862 MMAR_1604 Mycobacterium marinum M hypothetical protein YP_001849910.1 1940884 D 216594 CDS YP_001849911.1 183981620 6225863 1941781..1943313 1 NC_010612.1 hypothetical protein 1943313 6225863 MMAR_1605 Mycobacterium marinum M hypothetical protein YP_001849911.1 1941781 D 216594 CDS YP_001849912.1 183981621 6225864 1943310..1944797 1 NC_010612.1 function unknown, but involved in lipid degradation; fatty-acid-CoA ligase 1944797 6225864 MMAR_1606 Mycobacterium marinum M fatty-acid-CoA ligase YP_001849912.1 1943310 D 216594 CDS YP_001849913.1 183981622 6225865 1944890..1946437 1 NC_010612.1 involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H]; succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 1946437 putA_2 6225865 putA_2 Mycobacterium marinum M succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 YP_001849913.1 1944890 D 216594 CDS YP_001849914.1 183981623 6225866 complement(1946454..1948334) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hydrolase 1948334 6225866 MMAR_1608 Mycobacterium marinum M hydrolase YP_001849914.1 1946454 R 216594 CDS YP_001849915.1 183981624 6225867 complement(1948370..1948930) 1 NC_010612.1 hypothetical protein 1948930 6225867 MMAR_1609 Mycobacterium marinum M hypothetical protein YP_001849915.1 1948370 R 216594 CDS YP_001849916.1 183981625 6225868 complement(1949017..1949265) 1 NC_010612.1 hypothetical protein 1949265 6225868 MMAR_1610 Mycobacterium marinum M hypothetical protein YP_001849916.1 1949017 R 216594 CDS YP_001849917.1 183981626 6225869 complement(1949422..1950000) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 1950000 6225869 MMAR_1611 Mycobacterium marinum M transcriptional regulatory protein YP_001849917.1 1949422 R 216594 CDS YP_001849918.1 183981627 6225870 complement(1949997..1950320) 1 NC_010612.1 involved in transport of multidrugs (tetraphenylphosphonium, erythromycin, ethidium bromide, acriflavine, safranin O, pyronin Y, etc) across the membrane (export): multidrugs resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane; multidrug-transport integral membrane protein Mmr 1950320 mmr 6225870 mmr Mycobacterium marinum M multidrug-transport integral membrane protein Mmr YP_001849918.1 1949997 R 216594 CDS YP_001849919.1 183981628 6225871 complement(1950389..1951024) 1 NC_010612.1 hypothetical protein 1951024 6225871 MMAR_1613 Mycobacterium marinum M hypothetical protein YP_001849919.1 1950389 R 216594 CDS YP_001849920.1 183981629 6225872 complement(1951114..1951944) 1 NC_010612.1 short chain dehydrogenase 1951944 6225872 MMAR_1614 Mycobacterium marinum M short chain dehydrogenase YP_001849920.1 1951114 R 216594 CDS YP_001849921.1 183981630 6225873 complement(1951969..1953507) 1 NC_010612.1 acts as a chaperone. involved in induction by stress conditions E.G. heat shock. possibly has an ATPase activity. in M. tuberculosis H37Rv it is regulated positively by SigH and negatively by HspR; chaperone protein DnaK1 1953507 dnaK1 6225873 dnaK1 Mycobacterium marinum M chaperone protein DnaK1 YP_001849921.1 1951969 R 216594 CDS YP_001849922.1 183981631 6225874 complement(1953590..1955866) 1 NC_010612.1 peptide utilization during carbon starvation; carbon starvation protein, CstA 1955866 cstA 6225874 cstA Mycobacterium marinum M carbon starvation protein, CstA YP_001849922.1 1953590 R 216594 CDS YP_001849923.1 183981632 6225875 1956244..1957884 1 NC_010612.1 Catalyses the oxidation of cuprous copper, ferrous iron and diphenolic compounds. Protects against oxidative stress; multicopper oxidase, type 1, CueO 1957884 cueO 6225875 cueO Mycobacterium marinum M multicopper oxidase, type 1, CueO YP_001849923.1 1956244 D 216594 CDS YP_001849924.1 183981633 6225876 1957881..1958600 1 NC_010612.1 hypothetical protein 1958600 6225876 MMAR_1619 Mycobacterium marinum M hypothetical protein YP_001849924.1 1957881 D 216594 CDS YP_001849925.1 183981634 6225877 1958846..1959430 1 NC_010612.1 hypothetical protein 1959430 6225877 MMAR_1620 Mycobacterium marinum M hypothetical protein YP_001849925.1 1958846 D 216594 CDS YP_001849926.1 183981635 6225878 complement(1959445..1960179) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 1960179 6225878 MMAR_1621 Mycobacterium marinum M transcriptional regulatory protein YP_001849926.1 1959445 R 216594 CDS YP_001849927.1 183981636 6225879 1960367..1960861 1 NC_010612.1 hypothetical protein 1960861 6225879 MMAR_1622 Mycobacterium marinum M hypothetical protein YP_001849927.1 1960367 D 216594 CDS YP_001849928.1 183981637 6225880 complement(1960866..1962371) 1 NC_010612.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; ATP-dependent DNA ligase 1962371 ligB 6225880 ligB Mycobacterium marinum M ATP-dependent DNA ligase YP_001849928.1 1960866 R 216594 CDS YP_001849929.1 183981638 6225881 1962516..1963274 1 NC_010612.1 function unknown, supposed involved in cellular metabolism; short-chain type dehydrogenase/reductase 1963274 6225881 MMAR_1624 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001849929.1 1962516 D 216594 CDS YP_001849930.1 183981639 6225882 1963385..1965550 1 NC_010612.1 function unknown, but involved in lipid metabolism; acyl-CoA dehydrogenase FadE22 1965550 fadE22 6225882 fadE22 Mycobacterium marinum M acyl-CoA dehydrogenase FadE22 YP_001849930.1 1963385 D 216594 CDS YP_001849931.1 183981640 6225883 complement(1965584..1966258) 1 NC_010612.1 transcriptional regulator 1966258 6225883 MMAR_1626 Mycobacterium marinum M transcriptional regulator YP_001849931.1 1965584 R 216594 CDS YP_001849932.1 183981641 6225884 1966424..1967254 1 NC_010612.1 methyltransferase 1967254 6225884 MMAR_1627 Mycobacterium marinum M methyltransferase YP_001849932.1 1966424 D 216594 CDS YP_001849933.1 183981642 6225885 complement(1967255..1967611) 1 NC_010612.1 function unknown but potential nucleic-acid-binding domain; hypothetical protein 1967611 6225885 MMAR_1628 Mycobacterium marinum M hypothetical protein YP_001849933.1 1967255 R 216594 CDS YP_001849934.1 183981643 6225886 1967662..1968855 1 NC_010612.1 function unknown, supposed involvement in lipid metabolism; acetyl-CoA acetyltransferase 1968855 6225886 MMAR_1629 Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001849934.1 1967662 D 216594 CDS YP_001849935.1 183981644 6225887 1968869..1970344 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 1970344 6225887 MMAR_1630 Mycobacterium marinum M transcriptional regulatory protein YP_001849935.1 1968869 D 216594 CDS YP_001849936.1 183981645 6225888 1970467..1971429 1 NC_010612.1 hypothetical protein 1971429 6225888 MMAR_1631 Mycobacterium marinum M hypothetical protein YP_001849936.1 1970467 D 216594 CDS YP_001849937.1 183981646 6225889 complement(1971471..1971764) 1 NC_010612.1 hypothetical protein 1971764 6225889 MMAR_1632 Mycobacterium marinum M hypothetical protein YP_001849937.1 1971471 R 216594 CDS YP_001849938.1 183981647 6225890 1971935..1972465 1 NC_010612.1 hypothetical protein 1972465 6225890 MMAR_1633 Mycobacterium marinum M hypothetical protein YP_001849938.1 1971935 D 216594 CDS YP_001849939.1 183981648 6225891 complement(1972493..1973971) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 136A2 Cyp136A2 1973971 cyp136A2 6225891 cyp136A2 Mycobacterium marinum M cytochrome P450 136A2 Cyp136A2 YP_001849939.1 1972493 R 216594 CDS YP_001849940.1 183981649 6225892 1974082..1974735 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 1974735 6225892 MMAR_1635 Mycobacterium marinum M TetR family transcriptional regulator YP_001849940.1 1974082 D 216594 CDS YP_001849941.1 183981650 6225893 1974808..1975683 1 NC_010612.1 function unknown, but similar to various oxidoreductases and enzymes involved in polyketides synthesis; short chain dehydrogenase 1975683 6225893 MMAR_1636 Mycobacterium marinum M short chain dehydrogenase YP_001849941.1 1974808 D 216594 CDS YP_001849942.1 183981651 6225894 complement(1975724..1976326) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 1976326 6225894 MMAR_1637 Mycobacterium marinum M TetR family transcriptional regulator YP_001849942.1 1975724 R 216594 CDS YP_001849943.1 183981652 6225895 1976417..1976974 1 NC_010612.1 function unknown but domain identity suggests NADPH- dependent FMN reductase; hypothetical protein 1976974 6225895 MMAR_1638 Mycobacterium marinum M hypothetical protein YP_001849943.1 1976417 D 216594 CDS YP_001849944.1 183981653 6225896 1977457..1985721 1 NC_010612.1 PPE family protein 1985721 6225896 MMAR_1639 Mycobacterium marinum M PPE family protein YP_001849944.1 1977457 D 216594 CDS YP_001849945.1 183981654 6225897 1986233..1986472 1 NC_010612.1 involved in electron transfer system for ribonucleotide reductase system NRDEF; glutaredoxin electron transport component of NRDEF (glutaredoxin-like protein) NrdH 1986472 nrdH 6225897 nrdH Mycobacterium marinum M glutaredoxin electron transport component of NRDEF (glutaredoxin-like protein) NrdH YP_001849945.1 1986233 D 216594 CDS YP_001849946.1 183981655 6225898 1986516..1986977 1 NC_010612.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 1986977 nrdI 6225898 nrdI Mycobacterium marinum M ribonucleotide reductase stimulatory protein YP_001849946.1 1986516 D 216594 CDS YP_001849947.1 183981656 6225899 1986947..1989112 1 NC_010612.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1989112 nrdE 6225899 nrdE Mycobacterium marinum M ribonucleotide-diphosphate reductase subunit alpha YP_001849947.1 1986947 D 216594 CDS YP_001849948.1 183981657 6225900 1989227..1989970 1 NC_010612.1 involved in transcriptional mechanism; AsnC family transcriptional regulator 1989970 6225900 MMAR_1643 Mycobacterium marinum M AsnC family transcriptional regulator YP_001849948.1 1989227 D 216594 CDS YP_001849949.1 183981658 6225901 1990089..1991639 1 NC_010612.1 function unknown, involved in cellular metabolism; monooxygenase 1991639 6225901 MMAR_1644 Mycobacterium marinum M monooxygenase YP_001849949.1 1990089 D 216594 CDS YP_001849950.1 183981659 6225902 complement(1991629..1992174) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 1992174 6225902 MMAR_1645 Mycobacterium marinum M transcriptional regulatory protein YP_001849950.1 1991629 R 216594 CDS YP_001849951.1 183981660 6225903 complement(1992152..1992598) 1 NC_010612.1 hypothetical protein 1992598 6225903 MMAR_1646 Mycobacterium marinum M hypothetical protein YP_001849951.1 1992152 R 216594 CDS YP_001849952.1 183981661 6225904 1992809..1993783 1 NC_010612.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1993783 nrdF 6225904 nrdF Mycobacterium marinum M ribonucleotide-diphosphate reductase subunit beta YP_001849952.1 1992809 D 216594 CDS YP_001849953.1 183981662 6225905 1993818..1994294 1 NC_010612.1 hypothetical protein 1994294 6225905 MMAR_1648 Mycobacterium marinum M hypothetical protein YP_001849953.1 1993818 D 216594 CDS YP_001849954.1 183981663 6225906 complement(1994283..1995323) 1 NC_010612.1 alcohol dehydrogenase catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD: ethanol + NAD = acetaldehyde + NADH. belongs to the zinc-containing 'long-chain' alcohol dehydrogenases; NADP-dependent alcohol dehydrogenase Adh 1995323 adh 6225906 adh Mycobacterium marinum M NADP-dependent alcohol dehydrogenase Adh YP_001849954.1 1994283 R 216594 CDS YP_001849955.1 183981664 6225907 complement(1995457..1996551) 1 NC_010612.1 may be involved in active transport of FeIII- decitrate across the membrane (import); FEIII-dicitrate-binding periplasmic lipoprotein FecB 1996551 fecB 6225907 fecB Mycobacterium marinum M FEIII-dicitrate-binding periplasmic lipoprotein FecB YP_001849955.1 1995457 R 216594 CDS YP_001849956.1 183981665 6225908 1996730..1998451 1 NC_010612.1 cytochrome C oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. electrons originating in cytochrome C are transferred via the copper a center of subunit 2 and HemE a of subunit 1 to the bimetallic center formed by HemE A3 and copper B [catalytic activity: 4 ferrocytochrome C + O(2) = 2 H(2)O + 4 ferricytochrome C]; cytochrome C oxidase polypeptide I CtaD 1998451 ctaD 6225908 ctaD Mycobacterium marinum M cytochrome C oxidase polypeptide I CtaD YP_001849956.1 1996730 D 216594 CDS YP_001849957.1 183981666 6225909 1998504..1999739 1 NC_010612.1 generates serine from phosphoserine [catalytic activity: phosphoserine + H(2)O = serine + phosphate]; phosphoserine phosphatase SerB2 1999739 serB2 6225909 serB2 Mycobacterium marinum M phosphoserine phosphatase SerB2 YP_001849957.1 1998504 D 216594 CDS YP_001849958.1 183981667 6225910 1999921..2000265 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 2000265 6225910 MMAR_1653 Mycobacterium marinum M transcriptional regulatory protein YP_001849958.1 1999921 D 216594 CDS YP_001849959.1 183981668 6225911 2000280..2000759 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 2000759 6225911 MMAR_1654 Mycobacterium marinum M oxidoreductase YP_001849959.1 2000280 D 216594 CDS YP_001849960.1 183981669 6225912 2000756..2002732 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 2002732 6225912 MMAR_1655 Mycobacterium marinum M oxidoreductase YP_001849960.1 2000756 D 216594 CDS YP_001849961.1 183981670 6225913 2002729..2003688 1 NC_010612.1 involved in hydrogen metabolism; FHL pathway; formate hydrogenlyase HycD 2003688 hycD 6225913 hycD Mycobacterium marinum M formate hydrogenlyase HycD YP_001849961.1 2002729 D 216594 CDS YP_001849962.1 183981671 6225914 2003693..2004355 1 NC_010612.1 involved in hydrogen metabolism; hydrogenase HycP 2004355 hycP 6225914 hycP Mycobacterium marinum M hydrogenase HycP YP_001849962.1 2003693 D 216594 CDS YP_001849963.1 183981672 6225915 2004355..2005821 1 NC_010612.1 possibly involved in hydrogen metabolism; hydrogenase HycQ 2005821 hycQ 6225915 hycQ Mycobacterium marinum M hydrogenase HycQ YP_001849963.1 2004355 D 216594 CDS YP_001849964.1 183981673 6225916 2005821..2007317 1 NC_010612.1 involved in hydrogen metabolism; FHL pathway; formate hydrogenase HycE 2007317 hycE 6225916 hycE Mycobacterium marinum M formate hydrogenase HycE YP_001849964.1 2005821 D 216594 CDS YP_001849965.1 183981674 6225917 2007416..2008258 1 NC_010612.1 thought to be involved in active transport of undeterminated substrate (possibly iron) across the membrane. responsible for energy coupling to the transport system; ABC transporter ATP-binding protein 2008258 6225917 MMAR_1660 Mycobacterium marinum M ABC transporter ATP-binding protein YP_001849965.1 2007416 D 216594 CDS YP_001849966.1 183981675 6225918 2008255..2009097 1 NC_010612.1 hypothetical protein 2009097 6225918 MMAR_1661 Mycobacterium marinum M hypothetical protein YP_001849966.1 2008255 D 216594 CDS YP_001849967.1 183981676 6225919 2009094..2009867 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2009867 echA17 6225919 echA17 Mycobacterium marinum M enoyl-CoA hydratase YP_001849967.1 2009094 D 216594 CDS YP_001849968.1 183981677 6225920 2009878..2010861 1 NC_010612.1 hypothetical protein 2010861 6225920 MMAR_1663 Mycobacterium marinum M hypothetical protein YP_001849968.1 2009878 D 216594 CDS YP_001849969.1 183981678 6225921 2011026..2012063 1 NC_010612.1 hypothetical protein 2012063 6225921 MMAR_1664 Mycobacterium marinum M hypothetical protein YP_001849969.1 2011026 D 216594 CDS YP_001849970.1 183981679 6225922 2012147..2012821 1 NC_010612.1 hypothetical protein 2012821 6225922 MMAR_1665 Mycobacterium marinum M hypothetical protein YP_001849970.1 2012147 D 216594 CDS YP_001849971.1 183981680 6225923 complement(2012825..2013214) 1 NC_010612.1 hypothetical protein 2013214 6225923 MMAR_1666 Mycobacterium marinum M hypothetical protein YP_001849971.1 2012825 R 216594 CDS YP_001849972.1 183981681 6225924 complement(2013231..2014547) 1 NC_010612.1 hypothetical protein 2014547 6225924 MMAR_1667 Mycobacterium marinum M hypothetical protein YP_001849972.1 2013231 R 216594 CDS YP_001849973.1 183981682 6225925 2014724..2015461 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; transferase 2015461 6225925 MMAR_1668 Mycobacterium marinum M transferase YP_001849973.1 2014724 D 216594 CDS YP_001849974.1 183981683 6225926 complement(2015482..2016261) 1 NC_010612.1 function unknown; probably involved in lipid metabolism; lysophospholipase 2016261 6225926 MMAR_1669 Mycobacterium marinum M lysophospholipase YP_001849974.1 2015482 R 216594 CDS YP_001849975.1 183981684 6225927 complement(2016286..2016831) 1 NC_010612.1 hypothetical protein 2016831 6225927 MMAR_1670 Mycobacterium marinum M hypothetical protein YP_001849975.1 2016286 R 216594 CDS YP_001849976.1 183981685 6225928 complement(2016958..2018301) 1 NC_010612.1 function unknown, possible role in DNA replication, recombination, and repair; DNA photolyase, PhrI 2018301 phrI 6225928 phrI Mycobacterium marinum M DNA photolyase, PhrI YP_001849976.1 2016958 R 216594 CDS YP_001849977.1 183981686 6225929 complement(2018310..2018789) 1 NC_010612.1 function unknown. possibly involved in signal transduction mechanisms; tryptophan-rich sensory protein 2018789 6225929 MMAR_1672 Mycobacterium marinum M tryptophan-rich sensory protein YP_001849977.1 2018310 R 216594 CDS YP_001849978.1 183981687 6225930 complement(2018786..2020900) 1 NC_010612.1 function unknown. thought to be involved in drug export; transmembrane transport protein 2020900 6225930 MMAR_1673 Mycobacterium marinum M transmembrane transport protein YP_001849978.1 2018786 R 216594 CDS YP_001849979.1 183981688 6225931 2021115..2022323 1 NC_010612.1 thought to be involved in cell wall biosynthesis and may also act as a sensor of external penicillins; beta-lactamase 2022323 ampC 6225931 ampC Mycobacterium marinum M beta-lactamase YP_001849979.1 2021115 D 216594 CDS YP_001849980.1 183981689 6225932 2022434..2022937 1 NC_010612.1 transcriptional regulation; transcriptional regulator 2022937 6225932 MMAR_1675 Mycobacterium marinum M transcriptional regulator YP_001849980.1 2022434 D 216594 CDS YP_001849981.1 183981690 6225933 complement(2022940..2023347) 1 NC_010612.1 hypothetical protein 2023347 6225933 MMAR_1676 Mycobacterium marinum M hypothetical protein YP_001849981.1 2022940 R 216594 CDS YP_001849982.1 183981691 6225934 2023521..2024162 1 NC_010612.1 hypothetical protein 2024162 6225934 MMAR_1677 Mycobacterium marinum M hypothetical protein YP_001849982.1 2023521 D 216594 CDS YP_001849983.1 183981692 6225935 2024351..2025046 1 NC_010612.1 hypothetical protein 2025046 6225935 MMAR_1678 Mycobacterium marinum M hypothetical protein YP_001849983.1 2024351 D 216594 CDS YP_001849984.1 183981693 6225936 complement(2025051..2026406) 1 NC_010612.1 hypothetical protein 2026406 6225936 MMAR_1679 Mycobacterium marinum M hypothetical protein YP_001849984.1 2025051 R 216594 CDS YP_001849985.1 183981694 6225937 2026473..2027450 1 NC_010612.1 function unknown, probably involved in cellular metabolism; dehydrogenase/reductase 2027450 6225937 MMAR_1680 Mycobacterium marinum M dehydrogenase/reductase YP_001849985.1 2026473 D 216594 CDS YP_001849986.1 183981695 6225938 complement(2027447..2028691) 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; transferase 2028691 6225938 MMAR_1681 Mycobacterium marinum M transferase YP_001849986.1 2027447 R 216594 CDS YP_001849987.1 183981696 6225939 complement(2028783..2030378) 1 NC_010612.1 hypothetical protein 2030378 6225939 MMAR_1682 Mycobacterium marinum M hypothetical protein YP_001849987.1 2028783 R 216594 CDS YP_001849988.1 183981697 6225940 complement(2030375..2031193) 1 NC_010612.1 hypothetical protein 2031193 6225940 MMAR_1683 Mycobacterium marinum M hypothetical protein YP_001849988.1 2030375 R 216594 CDS YP_001849989.1 183981698 6225941 2031466..2032257 1 NC_010612.1 the electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. it transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase); electron transfer flavoprotein FixA 2032257 fixA 6225941 fixA Mycobacterium marinum M electron transfer flavoprotein FixA YP_001849989.1 2031466 D 216594 CDS YP_001849990.1 183981699 6225942 2032305..2033261 1 NC_010612.1 the electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. it transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase); electron transfer flavoprotein FixB 2033261 fixB 6225942 fixB Mycobacterium marinum M electron transfer flavoprotein FixB YP_001849990.1 2032305 D 216594 CDS YP_001849991.1 183981700 6225943 2033405..2034265 1 NC_010612.1 hypothetical protein 2034265 6225943 MMAR_1686 Mycobacterium marinum M hypothetical protein YP_001849991.1 2033405 D 216594 CDS YP_001849992.1 183981701 6225944 2034265..2035101 1 NC_010612.1 hypothetical protein 2035101 6225944 MMAR_1687 Mycobacterium marinum M hypothetical protein YP_001849992.1 2034265 D 216594 CDS YP_001849993.1 183981702 6225945 2035181..2035681 1 NC_010612.1 hypothetical protein 2035681 6225945 MMAR_1688 Mycobacterium marinum M hypothetical protein YP_001849993.1 2035181 D 216594 CDS YP_001849994.1 183981703 6225946 2035742..2036923 1 NC_010612.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; cysteine desulfurase IscS 2036923 iscS 6225946 iscS Mycobacterium marinum M cysteine desulfurase IscS YP_001849994.1 2035742 D 216594 CDS YP_001849995.1 183981704 6225947 2036938..2038011 1 NC_010612.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 2038011 mnmA 6225947 mnmA Mycobacterium marinum M tRNA-specific 2-thiouridylase MnmA YP_001849995.1 2036938 D 216594 CDS YP_001849996.1 183981705 6225948 complement(2038008..2038637) 1 NC_010612.1 lipoprotein LpqA 2038637 lpqA 6225948 lpqA Mycobacterium marinum M lipoprotein LpqA YP_001849996.1 2038008 R 216594 CDS YP_001849997.1 183981706 6225949 2038733..2039746 1 NC_010612.1 hypothetical protein 2039746 6225949 MMAR_1692 Mycobacterium marinum M hypothetical protein YP_001849997.1 2038733 D 216594 CDS YP_001849998.1 183981707 6225950 2040072..2041568 1 NC_010612.1 causes methylation; methyltransferase 2041568 6225950 MMAR_1693 Mycobacterium marinum M methyltransferase YP_001849998.1 2040072 D 216594 CDS YP_001849999.1 183981708 6225951 2041858..2043921 1 NC_010612.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2043921 ligA 6225951 ligA Mycobacterium marinum M NAD-dependent DNA ligase LigA YP_001849999.1 2041858 D 216594 CDS YP_001850000.1 183981709 6225952 2043991..2044587 1 NC_010612.1 possibly involved in a transcriptional mechanism; regulatory protein 2044587 6225952 MMAR_1695 Mycobacterium marinum M regulatory protein YP_001850000.1 2043991 D 216594 CDS YP_001850001.1 183981710 6225953 2044760..2045191 1 NC_010612.1 hypothetical protein 2045191 6225953 MMAR_1696 Mycobacterium marinum M hypothetical protein YP_001850001.1 2044760 D 216594 CDS YP_001850002.1 183981711 6225955 2045562..2045843 1 NC_010612.1 transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa1 2045843 6225955 MMAR_1698 Mycobacterium marinum M transposase, ISMyma01_aa1 YP_001850002.1 2045562 D 216594 CDS YP_001850003.1 183981712 6225956 2045885..2046679 1 NC_010612.1 transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa2 2046679 6225956 MMAR_1699 Mycobacterium marinum M transposase, ISMyma01_aa2 YP_001850003.1 2045885 D 216594 CDS YP_001850004.1 183981713 6225957 complement(2049340..2050032) 1 NC_010612.1 hypothetical protein 2050032 6225957 MMAR_1700 Mycobacterium marinum M hypothetical protein YP_001850004.1 2049340 R 216594 CDS YP_001850005.1 183981714 6225958 2050154..2050453 1 NC_010612.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 2050453 gatC 6225958 gatC Mycobacterium marinum M aspartyl/glutamyl-tRNA amidotransferase subunit C YP_001850005.1 2050154 D 216594 CDS YP_001850006.1 183981715 6225959 2050450..2051931 1 NC_010612.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 2051931 gatA 6225959 gatA Mycobacterium marinum M aspartyl/glutamyl-tRNA amidotransferase subunit A YP_001850006.1 2050450 D 216594 CDS YP_001850007.1 183981716 6225960 2052031..2053062 1 NC_010612.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 2053062 pfkA 6225960 pfkA Mycobacterium marinum M 6-phosphofructokinase YP_001850007.1 2052031 D 216594 CDS YP_001850008.1 183981717 6225961 2053345..2054853 1 NC_010612.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 2054853 gatB 6225961 gatB Mycobacterium marinum M aspartyl/glutamyl-tRNA amidotransferase subunit B YP_001850008.1 2053345 D 216594 CDS YP_001850009.1 183981718 6225962 2054890..2055489 1 NC_010612.1 function unknown; probably involved in cellular metabolism; oxidoreductase 2055489 6225962 MMAR_1705 Mycobacterium marinum M oxidoreductase YP_001850009.1 2054890 D 216594 CDS YP_001850010.1 183981719 6225963 complement(2055515..2056636) 1 NC_010612.1 lipoprotein LppZ 2056636 lppZ 6225963 lppZ Mycobacterium marinum M lipoprotein LppZ YP_001850010.1 2055515 R 216594 CDS YP_001850011.1 183981720 6225964 2056867..2057715 1 NC_010612.1 hypothetical protein 2057715 6225964 MMAR_1707 Mycobacterium marinum M hypothetical protein YP_001850011.1 2056867 D 216594 CDS YP_001850012.1 183981721 6225965 complement(2057724..2058101) 1 NC_010612.1 function unknown function (putative membrane protein); low molecular weight protein antigen 6, Cfp6 2058101 cfp6 6225965 cfp6 Mycobacterium marinum M low molecular weight protein antigen 6, Cfp6 YP_001850012.1 2057724 R 216594 CDS YP_001850013.1 183981722 6225966 2058155..2058286 1 NC_010612.1 hypothetical protein 2058286 6225966 MMAR_1709 Mycobacterium marinum M hypothetical protein YP_001850013.1 2058155 D 216594 CDS YP_001850014.1 183981723 6225967 2058430..2060286 1 NC_010612.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit 2060286 ilvB1 6225967 ilvB1 Mycobacterium marinum M acetolactate synthase 1 catalytic subunit YP_001850014.1 2058430 D 216594 CDS YP_001850015.1 183981724 6225968 2060286..2060795 1 NC_010612.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 2060795 ilvH 6225968 ilvH Mycobacterium marinum M acetolactate synthase 3 regulatory subunit YP_001850015.1 2060286 D 216594 CDS YP_001850016.1 183981725 6225969 2060838..2061869 1 NC_010612.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 2061869 ilvC 6225969 ilvC Mycobacterium marinum M ketol-acid reductoisomerase YP_001850016.1 2060838 D 216594 CDS YP_001850017.1 183981726 6225970 complement(2061956..2062558) 1 NC_010612.1 hypothetical protein 2062558 6225970 MMAR_1713 Mycobacterium marinum M hypothetical protein YP_001850017.1 2061956 R 216594 CDS YP_001850018.1 183981727 6225971 complement(2062555..2063985) 1 NC_010612.1 function unknown; probably involved in cellular metabolism; alanine rich dehydrogenase 2063985 6225971 MMAR_1714 Mycobacterium marinum M alanine rich dehydrogenase YP_001850018.1 2062555 R 216594 CDS YP_001850019.1 183981728 6225972 2064016..2065602 1 NC_010612.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 2065602 serA1 6225972 serA1 Mycobacterium marinum M D-3-phosphoglycerate dehydrogenase YP_001850019.1 2064016 D 216594 CDS YP_001850020.1 183981729 6225973 2065658..2066677 1 NC_010612.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 2066677 leuB 6225973 leuB Mycobacterium marinum M 3-isopropylmalate dehydrogenase YP_001850020.1 2065658 D 216594 CDS YP_001850021.1 183981730 6225974 complement(2066577..2067881) 1 NC_010612.1 function unknown; contains major facilitator superfamily (MFS). the MFS transporters are single- polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients; integral membrane transport protein 2067881 6225974 MMAR_1717 Mycobacterium marinum M integral membrane transport protein YP_001850021.1 2066577 R 216594 CDS YP_001850022.1 183981731 6225975 2068184..2068981 1 NC_010612.1 isomerizes HHDD (2-hydroxy-hept-2,4-diene-1,7- dioate) to ohed (2-OXO-hept-3-ene-1,7-dioate); 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 2068981 6225975 MMAR_1718 Mycobacterium marinum M 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase YP_001850022.1 2068184 D 216594 CDS YP_001850023.1 183981732 6225976 2068978..2070447 1 NC_010612.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2070447 gltX 6225976 gltX Mycobacterium marinum M glutamyl-tRNA synthetase YP_001850023.1 2068978 D 216594 CDS YP_001850024.1 183981733 6225979 complement(2070824..2071345) 1 NC_010612.1 hypothetical protein 2071345 6225979 MMAR_1720 Mycobacterium marinum M hypothetical protein YP_001850024.1 2070824 R 216594 CDS YP_001850025.1 183981734 6225980 2071498..2072463 1 NC_010612.1 hypothetical protein 2072463 6225980 MMAR_1721 Mycobacterium marinum M hypothetical protein YP_001850025.1 2071498 D 216594 CDS YP_001850026.1 183981735 6225981 complement(2072489..2075350) 1 NC_010612.1 function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL 2075350 mmpL1_1 6225981 mmpL1_1 Mycobacterium marinum M transmembrane transport protein MmpL YP_001850026.1 2072489 R 216594 CDS YP_001850027.1 183981736 6225982 complement(2075347..2075775) 1 NC_010612.1 membrane protein MmpS1 2075775 mmpS1 6225982 mmpS1 Mycobacterium marinum M membrane protein MmpS1 YP_001850027.1 2075347 R 216594 CDS YP_001850028.1 183981737 6225983 complement(2075994..2077244) 1 NC_010612.1 could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase 2077244 bioF2_2 6225983 bioF2_2 Mycobacterium marinum M 8-amino-7-oxononanoate synthase YP_001850028.1 2075994 R 216594 CDS YP_001850029.1 183981738 6225984 complement(2077795..2078496) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 2078496 6225984 MMAR_1725 Mycobacterium marinum M transcriptional regulatory protein YP_001850029.1 2077795 R 216594 CDS YP_001850030.1 183981739 6225985 2078579..2080000 1 NC_010612.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 2080000 leuC 6225985 leuC Mycobacterium marinum M isopropylmalate isomerase large subunit YP_001850030.1 2078579 D 216594 CDS YP_001850031.1 183981740 6225986 2080025..2080621 1 NC_010612.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 2080621 leuD 6225986 leuD Mycobacterium marinum M isopropylmalate isomerase small subunit YP_001850031.1 2080025 D 216594 CDS YP_001850032.1 183981741 6225987 2080846..2081508 1 NC_010612.1 this protein belongs to the histone like family of prokaryotic DNA-binding proteins which are capable of wrapping DNA to stabilize it, and prevent its denaturation under extreme environmental conditions; DNA-binding protein HU, HupB 2081508 hupB 6225987 hupB Mycobacterium marinum M DNA-binding protein HU, HupB YP_001850032.1 2080846 D 216594 CDS YP_001850033.1 183981742 6225988 complement(2081570..2082508) 1 NC_010612.1 function unknown, hydrolytic enzyme. possibly involved in removal of damaged nucleotide; hydrolase MutT1 2082508 mutT1 6225988 mutT1 Mycobacterium marinum M hydrolase MutT1 YP_001850033.1 2081570 R 216594 CDS YP_001850034.1 183981743 6225989 complement(2082588..2084804) 1 NC_010612.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2084804 ppk 6225989 ppk Mycobacterium marinum M polyphosphate kinase YP_001850034.1 2082588 R 216594 CDS YP_001850035.1 183981744 6225990 complement(2084883..2085536) 1 NC_010612.1 hypothetical protein 2085536 6225990 MMAR_1731 Mycobacterium marinum M hypothetical protein YP_001850035.1 2084883 R 216594 CDS YP_001850036.1 183981745 6225991 2085728..2086735 1 NC_010612.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 2086735 gpsA 6225991 gpsA Mycobacterium marinum M NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_001850036.1 2085728 D 216594 CDS YP_001850037.1 183981746 6225992 2086827..2087948 1 NC_010612.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 2087948 ddl 6225992 ddl Mycobacterium marinum M D-alanyl-alanine synthetase A YP_001850037.1 2086827 D 216594 CDS YP_001850038.1 183981747 6225993 complement(2087945..2088571) 1 NC_010612.1 hypothetical protein 2088571 6225993 MMAR_1734 Mycobacterium marinum M hypothetical protein YP_001850038.1 2087945 R 216594 CDS YP_001850039.1 183981748 6225994 2088737..2089702 1 NC_010612.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 2089702 thiL 6225994 thiL Mycobacterium marinum M thiamine monophosphate kinase YP_001850039.1 2088737 D 216594 CDS YP_001850040.1 183981749 6225995 2089728..2090018 1 NC_010612.1 hypothetical protein 2090018 6225995 MMAR_1736 Mycobacterium marinum M hypothetical protein YP_001850040.1 2089728 D 216594 CDS YP_001850041.1 183981750 6225996 2090015..2090698 1 NC_010612.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2090698 ung 6225996 ung Mycobacterium marinum M uracil-DNA glycosylase YP_001850041.1 2090015 D 216594 CDS YP_001850042.1 183981751 6225997 2090704..2091636 1 NC_010612.1 thought to be involved in fatty acid degradation. FadB and FadA are the alpha and beta subunits of the multifunctional enzyme complex of the fatty acid degradation cycle; oxidoreductase 2091636 6225997 MMAR_1738 Mycobacterium marinum M oxidoreductase YP_001850042.1 2090704 D 216594 CDS YP_001850043.1 183981752 6225998 2091686..2092336 1 NC_010612.1 function unknown; probably involved in cellular metabolism; nitroreductase 2092336 6225998 MMAR_1739 Mycobacterium marinum M nitroreductase YP_001850043.1 2091686 D 216594 CDS YP_001850044.1 183981753 6225999 complement(2092492..2092686) 1 NC_010612.1 required for 70S ribosome assembly; 50S ribosomal protein L28 2092686 rpmB 6225999 rpmB Mycobacterium marinum M 50S ribosomal protein L28 YP_001850044.1 2092492 R 216594 CDS YP_001850045.1 183981754 6226000 2092969..2094663 1 NC_010612.1 hypothetical protein 2094663 6226000 MMAR_1741 Mycobacterium marinum M hypothetical protein YP_001850045.1 2092969 D 216594 CDS YP_001850046.1 183981755 6226001 2094666..2096897 1 NC_010612.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 2096897 recG 6226001 recG Mycobacterium marinum M ATP-dependent DNA helicase RecG YP_001850046.1 2094666 D 216594 CDS YP_001850047.1 183981756 6226002 2096902..2097615 1 NC_010612.1 hypothetical protein 2097615 6226002 MMAR_1743 Mycobacterium marinum M hypothetical protein YP_001850047.1 2096902 D 216594 CDS YP_001850048.1 183981757 6226003 complement(2097620..2098465) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 2098465 6226003 MMAR_1744 Mycobacterium marinum M oxidoreductase YP_001850048.1 2097620 R 216594 CDS YP_001850049.1 183981758 6226004 complement(2098655..2098990) 1 NC_010612.1 hypothetical protein 2098990 6226004 MMAR_1745 Mycobacterium marinum M hypothetical protein YP_001850049.1 2098655 R 216594 CDS YP_001850050.1 183981759 6226005 2099035..2100153 1 NC_010612.1 function unknown, lipolytic enzyme involved in cellular metabolism; lipase/esterase LipN 2100153 lipN 6226005 lipN Mycobacterium marinum M lipase/esterase LipN YP_001850050.1 2099035 D 216594 CDS YP_001850051.1 183981760 6226006 2100340..2101107 1 NC_010612.1 hypothetical protein 2101107 6226006 MMAR_1747 Mycobacterium marinum M hypothetical protein YP_001850051.1 2100340 D 216594 CDS YP_001850052.1 183981761 6226007 2101113..2101751 1 NC_010612.1 integral membrane protein 2101751 6226007 MMAR_1748 Mycobacterium marinum M integral membrane protein YP_001850052.1 2101113 D 216594 CDS YP_001850053.1 183981762 6226008 2101794..2105189 1 NC_010612.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase 2105189 pca 6226008 pca Mycobacterium marinum M pyruvate carboxylase YP_001850053.1 2101794 D 216594 CDS YP_001850054.1 183981763 6226009 2105267..2105740 1 NC_010612.1 thought to cause methylation; methyltransferase 2105740 6226009 MMAR_1750 Mycobacterium marinum M methyltransferase YP_001850054.1 2105267 D 216594 CDS YP_001850055.1 183981764 6226010 2105814..2106287 1 NC_010612.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 2106287 coaD 6226010 coaD Mycobacterium marinum M phosphopantetheine adenylyltransferase YP_001850055.1 2105814 D 216594 CDS YP_001850056.1 183981765 6226011 complement(2106371..2106553) 1 NC_010612.1 hypothetical protein 2106553 6226011 MMAR_1752 Mycobacterium marinum M hypothetical protein YP_001850056.1 2106371 R 216594 CDS YP_001850057.1 183981766 6226012 complement(2106710..2107606) 1 NC_010612.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 2107606 purU 6226012 purU Mycobacterium marinum M formyltetrahydrofolate deformylase YP_001850057.1 2106710 R 216594 CDS YP_001850058.1 183981767 6226013 complement(2107640..2108821) 1 NC_010612.1 hypothetical protein 2108821 6226013 MMAR_1754 Mycobacterium marinum M hypothetical protein YP_001850058.1 2107640 R 216594 CDS YP_001850059.1 183981768 6226014 2109311..2110573 1 NC_010612.1 involved in PGL biosynthesis. in M. tuberculosis H37Rv, the product of the mu orthologue (Rv2962c) catalyzes the transfer of a rhamnosyl residue onto p- hydroxybenzoic acid ethyl ester or phenolphthiocerol dimycocerosates; glycosyl transferase family protein 2110573 6226014 MMAR_1755 Mycobacterium marinum M glycosyl transferase family protein YP_001850059.1 2109311 D 216594 CDS YP_001850060.1 183981769 6226015 2110734..2111531 1 NC_010612.1 hypothetical protein 2111531 6226015 MMAR_1756 Mycobacterium marinum M hypothetical protein YP_001850060.1 2110734 D 216594 CDS YP_001850061.1 183981770 6226016 complement(2111582..2112838) 1 NC_010612.1 hypothetical protein 2112838 6226016 MMAR_1757 Mycobacterium marinum M hypothetical protein YP_001850061.1 2111582 R 216594 CDS YP_001850062.1 183981771 6226017 2113051..2114208 1 NC_010612.1 function unknown; probably involved in cellular metabolism; ketoreductase 2114208 6226017 MMAR_1758 Mycobacterium marinum M ketoreductase YP_001850062.1 2113051 D 216594 CDS YP_001850063.1 183981772 6226018 2115037..2116905 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2116905 fadD29 6226018 fadD29 Mycobacterium marinum M acyl-CoA synthetase YP_001850063.1 2115037 D 216594 CDS YP_001850064.1 183981773 6226019 2116910..2117548 1 NC_010612.1 responsible for the direct conversion of chorismate to p-hydroxybenzoate, the substrate used in the production of glycosylated p-hydroxybenzoic acid methyl esters and structurally related phenolphthiocerol glycolipids. in M. tuberculosis, this is the sole enzymatic source of p- hydroxybenzoic acid; chorismate pyruvate-lyase 2117548 6226019 MMAR_1760 Mycobacterium marinum M chorismate pyruvate-lyase YP_001850064.1 2116910 D 216594 CDS YP_001850065.1 183981774 6226020 2117667..2119775 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2119775 fadD22 6226020 fadD22 Mycobacterium marinum M acyl-CoA synthetase YP_001850065.1 2117667 D 216594 CDS YP_001850066.1 183981775 6226021 2119792..2126106 1 NC_010612.1 polyketide synthase required for the elongation of p-HBAD derivatives to form p-hydroxybenzoate derivatives which are in turn converted to phenolphthiocerols by the ppsA-E locus. this is a key step in the production of phenolic glycolipids; polyketide synthase 2126106 pks15/1 6226021 pks15/1 Mycobacterium marinum M polyketide synthase YP_001850066.1 2119792 D 216594 CDS YP_001850067.1 183981776 6226022 2126521..2127210 1 NC_010612.1 lipoprotein LppX 2127210 lppX 6226022 lppX Mycobacterium marinum M lipoprotein LppX YP_001850067.1 2126521 D 216594 CDS YP_001850068.1 183981777 6226023 complement(2127250..2130000) 1 NC_010612.1 involved in translocation of phthiocerol dimycocerosate (dim) in the cell wall; transmembrane transport protein MmpL7 2130000 mmpL7 6226023 mmpL7 Mycobacterium marinum M transmembrane transport protein MmpL7 YP_001850068.1 2127250 R 216594 CDS YP_001850069.1 183981778 6226024 complement(2130002..2131744) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2131744 fadD28 6226024 fadD28 Mycobacterium marinum M acyl-CoA synthetase YP_001850069.1 2130002 R 216594 CDS YP_001850070.1 183981779 6226025 2132180..2132992 1 NC_010612.1 function unknown but orthologue in M. tuberculosis H37Rv has been shown to catalyze the transfer of a methyl group onto the lipid moiety of phthiotriol dimycocerosates to form dim; methyltransferase 2132992 6226025 MMAR_1766 Mycobacterium marinum M methyltransferase YP_001850070.1 2132180 D 216594 CDS YP_001850071.1 183981780 6226026 2133553..2139852 1 NC_010612.1 catalyzes the elongation of N-fatty acyl-CoA with methylamalonyl-CoA (not malonyl-CoA) as the elongating agent to form mycocerosyl lipids; multifunctional mycocerosic acid synthase membrane-associated Mas 2139852 mas 6226026 mas Mycobacterium marinum M multifunctional mycocerosic acid synthase membrane-associated Mas YP_001850071.1 2133553 D 216594 CDS YP_001850072.1 183981781 6226027 complement(2140056..2141300) 1 NC_010612.1 required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis; acyltransferase PapA5 2141300 papA5 6226027 papA5 Mycobacterium marinum M acyltransferase PapA5 YP_001850072.1 2140056 R 216594 CDS YP_001850073.1 183981782 6226028 complement(2141334..2142155) 1 NC_010612.1 probably involved in active transport of phthiocerol dimycocerosate (dim) across the membrane (export). DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. probably responsible for the translocation of the substrate across the membrane and localization of dim into the cell wall; daunorubicin-DIM-transport integral membrane protein ABC transporter DrrC 2142155 drrC 6226028 drrC Mycobacterium marinum M daunorubicin-DIM-transport integral membrane protein ABC transporter DrrC YP_001850073.1 2141334 R 216594 CDS YP_001850074.1 183981783 6226029 complement(2142161..2143030) 1 NC_010612.1 probably involved in active transport of phthiocerol dimycocerosate (dim) across the membrane (export). DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. probably responsible for the translocation of the substrate across the membrane and localization of dim into the cell wall; daunorubicin-DIM-transport integral membrane protein ABC transporter DrrB 2143030 drrB 6226029 drrB Mycobacterium marinum M daunorubicin-DIM-transport integral membrane protein ABC transporter DrrB YP_001850074.1 2142161 R 216594 CDS YP_001850075.1 183981784 6226030 complement(2143027..2144022) 1 NC_010612.1 probably involved in active transport of antibiotic and phthiocerol dimycocerosate (dim) across the membrane (export). DrrA, DrrB and DrrC may act jointly to confer daunorubicin and doxorubicin resistance by an export mechanism. responsible for energy coupling to the transport system; daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA 2144022 drrA 6226030 drrA Mycobacterium marinum M daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA YP_001850075.1 2143027 R 216594 CDS YP_001850076.1 183981785 6226031 complement(2144033..2148478) 1 NC_010612.1 involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension with Malony CoA (partial reduction, decarboxylation); phenolpthiocerol synthesis type-I polyketide synthase PpsE 2148478 ppsE 6226031 ppsE Mycobacterium marinum M phenolpthiocerol synthesis type-I polyketide synthase PpsE YP_001850076.1 2144033 R 216594 CDS YP_001850077.1 183981786 6226032 complement(2148484..2153904) 1 NC_010612.1 involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension with methylmalony CoA (partial reduction); phenolpthiocerol synthesis type-I polyketide synthase PpsD 2153904 ppsD 6226032 ppsD Mycobacterium marinum M phenolpthiocerol synthesis type-I polyketide synthase PpsD YP_001850077.1 2148484 R 216594 CDS YP_001850078.1 183981787 6226033 complement(2153904..2160509) 1 NC_010612.1 involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension with Malony CoA (complete reduction); phenolpthiocerol synthesis type-I polyketide synthase PpsC 2160509 ppsC 6226033 ppsC Mycobacterium marinum M phenolpthiocerol synthesis type-I polyketide synthase PpsC YP_001850078.1 2153904 R 216594 CDS YP_001850079.1 183981788 6226034 complement(2160509..2165083) 1 NC_010612.1 involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension with Malony CoA (partial reduction); phenolpthiocerol synthesis type-I polyketide synthase PpsB 2165083 ppsB 6226034 ppsB Mycobacterium marinum M phenolpthiocerol synthesis type-I polyketide synthase PpsB YP_001850079.1 2160509 R 216594 CDS YP_001850080.1 183981789 6226035 complement(2165083..2169891) 1 NC_010612.1 involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension of C18 with Malony CoA (partial reduction); phenolpthiocerol synthesis type-I polyketide synthase PpsA 2169891 ppsA 6226035 ppsA Mycobacterium marinum M phenolpthiocerol synthesis type-I polyketide synthase PpsA YP_001850080.1 2165083 R 216594 CDS YP_001850081.1 183981790 6226036 complement(2169888..2171642) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2171642 fadD26 6226036 fadD26 Mycobacterium marinum M acyl-CoA synthetase YP_001850081.1 2169888 R 216594 CDS YP_001850082.1 183981791 6226037 complement(2172321..2173070) 1 NC_010612.1 function unknown however in M. tuberculosis H37Rv TesA interacts with the PpsE protein. PpsE is part of the phenolphthiocerol synthase PKS cluster; thioesterase TesA 2173070 tesA 6226037 tesA Mycobacterium marinum M thioesterase TesA YP_001850082.1 2172321 R 216594 CDS YP_001850083.1 183981792 6226038 complement(2173067..2173291) 1 NC_010612.1 hypothetical protein 2173291 6226038 MMAR_1779 Mycobacterium marinum M hypothetical protein YP_001850083.1 2173067 R 216594 CDS YP_001850084.1 183981793 6226039 2173370..2174113 1 NC_010612.1 function unknown, possibly involved in cell division and chromosome partitioning; hypothetical protein 2174113 6226039 MMAR_1780 Mycobacterium marinum M hypothetical protein YP_001850084.1 2173370 D 216594 CDS YP_001850085.1 183981794 6226040 2174188..2174781 1 NC_010612.1 hypothetical protein 2174781 6226040 MMAR_1781 Mycobacterium marinum M hypothetical protein YP_001850085.1 2174188 D 216594 CDS YP_001850086.1 183981795 6226041 2174784..2175509 1 NC_010612.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2175509 rnc 6226041 rnc Mycobacterium marinum M ribonuclease III YP_001850086.1 2174784 D 216594 CDS YP_001850087.1 183981796 6226042 2175510..2176388 1 NC_010612.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 2176388 fpg 6226042 fpg Mycobacterium marinum M formamidopyrimidine-DNA glycosylase YP_001850087.1 2175510 D 216594 CDS YP_001850088.1 183981797 6226043 2176479..2177171 1 NC_010612.1 function unknown. contains N-term OsmC-like protein domain and C-term AcyP, acylphosphatases domain; hypothetical protein 2177171 6226043 MMAR_1784 Mycobacterium marinum M hypothetical protein YP_001850088.1 2176479 D 216594 CDS YP_001850089.1 183981798 6226044 2177270..2180872 1 NC_010612.1 plays an important role in chromosome structure and partitioning. essential for chromosome partition; chromosome partition protein Smc 2180872 smc 6226044 smc Mycobacterium marinum M chromosome partition protein Smc YP_001850089.1 2177270 D 216594 CDS YP_001850090.1 183981799 6226045 2180932..2182308 1 NC_010612.1 probably involved in the reception and insertion of a subset of proteins at the membrane: possibly membrane receptor for Ffh; cell division protein FtsY 2182308 ftsY 6226045 ftsY Mycobacterium marinum M cell division protein FtsY YP_001850090.1 2180932 D 216594 CDS YP_001850091.1 183981800 6226046 2182452..2183885 1 NC_010612.1 thought to be involved in transport of ammonium across the membrane (export). responsible for the translocation of the substrate across the membrane; ammonium-transport integral membrane protein Amt 2183885 amt 6226046 amt Mycobacterium marinum M ammonium-transport integral membrane protein Amt YP_001850091.1 2182452 D 216594 CDS YP_001850092.1 183981801 6226047 2183882..2184220 1 NC_010612.1 in nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP by GlnD. P-II-UMP allows the deadenylylation of glutamine synthetase (gs), thus activating the enzyme. converserly, in nitrogen excess P-II is deuridylated and promotes the adenylation of gs. P-II indirectly controls the transcription of the gs gene. P-II prevents NR-II catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. when P-II is uridylylated to P-II-UMP, these events are reversed; nitrogen regulatory protein P-II GlnB 2184220 glnB 6226047 glnB Mycobacterium marinum M nitrogen regulatory protein P-II GlnB YP_001850092.1 2183882 D 216594 CDS YP_001850093.1 183981802 6226048 2184314..2186752 1 NC_010612.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; also involved in adenylylating and deadelnylyating GlnK; PII uridylyl-transferase 2186752 glnD 6226048 glnD Mycobacterium marinum M PII uridylyl-transferase YP_001850093.1 2184314 D 216594 CDS YP_001850094.1 183981803 6226049 complement(2186780..2188516) 1 NC_010612.1 hypothetical protein 2188516 6226049 MMAR_1790 Mycobacterium marinum M hypothetical protein YP_001850094.1 2186780 R 216594 CDS YP_001850095.1 183981804 6226050 complement(2188732..2188947) 1 NC_010612.1 hypothetical protein 2188947 6226050 MMAR_1791 Mycobacterium marinum M hypothetical protein YP_001850095.1 2188732 R 216594 CDS YP_001850096.1 183981805 6226051 2189086..2190675 1 NC_010612.1 necessary for efficient export of extra-cytoplasmic proteins. binds to the signal sequence when it emerges from the ribosomes; signal recognition particle protein Ffh 2190675 ffh 6226051 ffh Mycobacterium marinum M signal recognition particle protein Ffh YP_001850096.1 2189086 D 216594 CDS YP_001850097.1 183981806 6226052 2190682..2191773 1 NC_010612.1 hypothetical protein 2191773 6226052 MMAR_1793 Mycobacterium marinum M hypothetical protein YP_001850097.1 2190682 D 216594 CDS YP_001850098.1 183981807 6226053 2191822..2193624 1 NC_010612.1 involved in signal transduction (via phosphorylation). thought to be involved in cell division/differentiation [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 2193624 pknI 6226053 pknI Mycobacterium marinum M Ser/Thr protein kinase YP_001850098.1 2191822 D 216594 CDS YP_001850099.1 183981808 6226054 2193729..2195522 1 NC_010612.1 hydrolizes a specific D-amino acid; D-amino acid aminohydrolase 2195522 6226054 MMAR_1795 Mycobacterium marinum M D-amino acid aminohydrolase YP_001850099.1 2193729 D 216594 CDS YP_001850100.1 183981809 6226055 2195524..2196126 1 NC_010612.1 thought to be involved in transcriptional mechanism; TetR family transcriptional regulator 2196126 6226055 MMAR_1796 Mycobacterium marinum M TetR family transcriptional regulator YP_001850100.1 2195524 D 216594 CDS YP_001850101.1 183981810 6226056 complement(2196146..2197018) 1 NC_010612.1 involved in peptidoglycan synthesis (at final stages). hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine]; D-alanyl-D-alanine carboxypeptidase 2197018 dacB 6226056 dacB Mycobacterium marinum M D-alanyl-D-alanine carboxypeptidase YP_001850101.1 2196146 R 216594 CDS YP_001850102.1 183981811 6226057 2197090..2197509 1 NC_010612.1 hypothetical protein 2197509 6226057 MMAR_1798 Mycobacterium marinum M hypothetical protein YP_001850102.1 2197090 D 216594 CDS YP_001850103.1 183981812 6226058 2197715..2198200 1 NC_010612.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2198200 rpsP 6226058 rpsP Mycobacterium marinum M 30S ribosomal protein S16 YP_001850103.1 2197715 D 216594 CDS YP_001850104.1 183981813 6226059 2198209..2198451 1 NC_010612.1 hypothetical protein 2198451 6226059 MMAR_1800 Mycobacterium marinum M hypothetical protein YP_001850104.1 2198209 D 216594 CDS YP_001850105.1 183981814 6226060 2198476..2199000 1 NC_010612.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2199000 rimM 6226060 rimM Mycobacterium marinum M 16S rRNA-processing protein RimM YP_001850105.1 2198476 D 216594 CDS YP_001850106.1 183981815 6226061 2199010..2199702 1 NC_010612.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2199702 trmD 6226061 trmD Mycobacterium marinum M tRNA (guanine-N(1)-)-methyltransferase YP_001850106.1 2199010 D 216594 CDS YP_001850107.1 183981816 6226062 complement(2199814..2200773) 1 NC_010612.1 alanine rich lipoprotein LppW 2200773 lppW 6226062 lppW Mycobacterium marinum M alanine rich lipoprotein LppW YP_001850107.1 2199814 R 216594 CDS YP_001850108.1 183981817 6226063 2201131..2201472 1 NC_010612.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2201472 rplS 6226063 rplS Mycobacterium marinum M 50S ribosomal protein L19 YP_001850108.1 2201131 D 216594 CDS YP_001850109.1 183981818 6226064 2201584..2202447 1 NC_010612.1 cleavage of N-terminal leader sequences from secreted protein precursors; signal peptidase I LepB 2202447 lepB 6226064 lepB Mycobacterium marinum M signal peptidase I LepB YP_001850109.1 2201584 D 216594 CDS YP_001850110.1 183981819 6226065 2202450..2203169 1 NC_010612.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 2203169 rnhB 6226065 rnhB Mycobacterium marinum M ribonuclease HII YP_001850110.1 2202450 D 216594 CDS YP_001850111.1 183981820 6226066 2203300..2203605 1 NC_010612.1 hypothetical protein 2203605 6226066 MMAR_1807 Mycobacterium marinum M hypothetical protein YP_001850111.1 2203300 D 216594 CDS YP_001850112.1 183981821 6226067 complement(2203611..2204396) 1 NC_010612.1 hypothetical protein 2204396 6226067 MMAR_1808 Mycobacterium marinum M hypothetical protein YP_001850112.1 2203611 R 216594 CDS YP_001850113.1 183981822 6226068 complement(2204474..2205832) 1 NC_010612.1 hypothetical protein 2205832 6226068 MMAR_1809 Mycobacterium marinum M hypothetical protein YP_001850113.1 2204474 R 216594 CDS YP_001850114.1 183981823 6226069 2205950..2206930 1 NC_010612.1 contains WcaG, nucleoside-diphosphate-sugar epimerase domain.; function unknown, possibly involved in galactose metabolism; UDP-glucose 4-epimerase 2206930 galE4 6226069 galE4 Mycobacterium marinum M UDP-glucose 4-epimerase YP_001850114.1 2205950 D 216594 CDS YP_001850115.1 183981824 6226070 2207065..2207886 1 NC_010612.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 2207886 fdhD 6226070 fdhD Mycobacterium marinum M formate dehydrogenase accessory protein YP_001850115.1 2207065 D 216594 CDS YP_001850116.1 183981825 6226071 2208003..2208371 1 NC_010612.1 hypothetical protein 2208371 6226071 MMAR_1812 Mycobacterium marinum M hypothetical protein YP_001850116.1 2208003 D 216594 CDS YP_001850117.1 183981826 6226072 2208371..2209882 1 NC_010612.1 hypothetical protein 2209882 6226072 MMAR_1813 Mycobacterium marinum M hypothetical protein YP_001850117.1 2208371 D 216594 CDS YP_001850118.1 183981827 6226073 2209879..2211054 1 NC_010612.1 hypothetical protein 2211054 6226073 MMAR_1814 Mycobacterium marinum M hypothetical protein YP_001850118.1 2209879 D 216594 CDS YP_001850119.1 183981828 6226074 2211087..2211935 1 NC_010612.1 thought to be involved in intracellular removal of iron from iron-mycobactin complex. mycobactin is an iron- chelating compound involved in the transport of iron from the bacterial environment into the cell cytoplasm; mycobactin utilization protein ViuB 2211935 viuB 6226074 viuB Mycobacterium marinum M mycobactin utilization protein ViuB YP_001850119.1 2211087 D 216594 CDS YP_001850120.1 183981829 6226075 2211959..2213119 1 NC_010612.1 involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C]; L-lactate dehydrogenase (cytochrome) LldD1 2213119 lldD1_1 6226075 lldD1_1 Mycobacterium marinum M L-lactate dehydrogenase (cytochrome) LldD1 YP_001850120.1 2211959 D 216594 CDS YP_001850121.1 183981830 6226076 2213151..2214059 1 NC_010612.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 2214059 xerC 6226076 xerC Mycobacterium marinum M site-specific tyrosine recombinase XerC YP_001850121.1 2213151 D 216594 CDS YP_001850122.1 183981831 6226077 complement(2214081..2214587) 1 NC_010612.1 hypothetical protein 2214587 6226077 MMAR_1818 Mycobacterium marinum M hypothetical protein YP_001850122.1 2214081 R 216594 CDS YP_001850123.1 183981832 6226078 2214892..2215722 1 NC_010612.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 2215722 rpsB 6226078 rpsB Mycobacterium marinum M 30S ribosomal protein S2 YP_001850123.1 2214892 D 216594 CDS YP_001850124.1 183981833 6226079 2215724..2216539 1 NC_010612.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 2216539 tsf 6226079 tsf Mycobacterium marinum M elongation factor Ts YP_001850124.1 2215724 D 216594 CDS YP_001850125.1 183981834 6226080 2216560..2217978 1 NC_010612.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 2217978 amiC 6226080 amiC Mycobacterium marinum M amidase YP_001850125.1 2216560 D 216594 CDS YP_001850126.1 183981835 6226081 complement(2217994..2218413) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 2218413 6226081 MMAR_1822 Mycobacterium marinum M transcriptional regulatory protein YP_001850126.1 2217994 R 216594 CDS YP_001850127.1 183981836 6226082 2218724..2219185 1 NC_010612.1 hypothetical protein 2219185 6226082 MMAR_1823 Mycobacterium marinum M hypothetical protein YP_001850127.1 2218724 D 216594 CDS YP_001850128.1 183981837 6226083 2219304..2220254 1 NC_010612.1 hypothetical protein 2220254 6226083 MMAR_1824 Mycobacterium marinum M hypothetical protein YP_001850128.1 2219304 D 216594 CDS YP_001850129.1 183981838 6226084 complement(2220255..2221055) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 2221055 6226084 MMAR_1825 Mycobacterium marinum M transcriptional regulatory protein YP_001850129.1 2220255 R 216594 CDS YP_001850130.1 183981839 6226085 2221450..2222247 1 NC_010612.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 2222247 pyrH 6226085 pyrH Mycobacterium marinum M uridylate kinase YP_001850130.1 2221450 D 216594 CDS YP_001850131.1 183981840 6226086 2222312..2222869 1 NC_010612.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 2222869 frr 6226086 frr Mycobacterium marinum M ribosome recycling factor YP_001850131.1 2222312 D 216594 CDS YP_001850132.1 183981841 6226087 2222902..2223816 1 NC_010612.1 involved in the phospholipid biosynthesis [catalytic activity: CTP + phosphatidate = pyrophosphate + CDP-diacylglycerol]; integral membrane phosphatidate cytidylyltransferase CdsA 2223816 cdsA 6226087 cdsA Mycobacterium marinum M integral membrane phosphatidate cytidylyltransferase CdsA YP_001850132.1 2222902 D 216594 CDS YP_001850133.1 183981842 6226088 2224183..2229807 1 NC_010612.1 PE-PGRS family protein 2229807 6226088 MMAR_1829 Mycobacterium marinum M PE-PGRS family protein YP_001850133.1 2224183 D 216594 CDS YP_001850134.1 183981843 6226089 2229847..2230941 1 NC_010612.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 2230941 6226089 MMAR_1830 Mycobacterium marinum M ribosomal RNA large subunit methyltransferase N YP_001850134.1 2229847 D 216594 CDS YP_001850135.1 183981844 6226090 2231015..2231536 1 NC_010612.1 despite a weak homology to thioredoxin this cannot serve as a substrate for thioredoxin reductase; furthermore it has no disulfide reducing activity; soluble secreted antigen Mpt53 precursor 2231536 mpt53 6226090 mpt53 Mycobacterium marinum M soluble secreted antigen Mpt53 precursor YP_001850135.1 2231015 D 216594 CDS YP_001850136.1 183981845 6226091 2231550..2232422 1 NC_010612.1 function unknown, possibly involved in transport of mercury across the membrane; integral membrane protein 2232422 6226091 MMAR_1832 Mycobacterium marinum M integral membrane protein YP_001850136.1 2231550 D 216594 CDS YP_001850137.1 183981846 6226092 2232438..2232860 1 NC_010612.1 hypothetical protein 2232860 6226092 MMAR_1833 Mycobacterium marinum M hypothetical protein YP_001850137.1 2232438 D 216594 CDS YP_001850138.1 183981847 6226093 complement(2232872..2233465) 1 NC_010612.1 major secreted immunogenic protein Mpt70 2233465 mpt70 6226093 mpt70 Mycobacterium marinum M major secreted immunogenic protein Mpt70 YP_001850138.1 2232872 R 216594 CDS YP_001850139.1 183981848 6226094 complement(2233553..2235364) 1 NC_010612.1 may be involved in cytochrome-c biogenesis; integral membrane C-type cytochrome biogenesis protein DipZ 2235364 dipZ 6226094 dipZ Mycobacterium marinum M integral membrane C-type cytochrome biogenesis protein DipZ YP_001850139.1 2233553 R 216594 CDS YP_001850140.1 183981849 6226095 2235392..2236600 1 NC_010612.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 2236600 dxr 6226095 dxr Mycobacterium marinum M 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_001850140.1 2235392 D 216594 CDS YP_001850141.1 183981850 6226096 2236620..2237834 1 NC_010612.1 transmembrane protein 2237834 6226096 MMAR_1837 Mycobacterium marinum M transmembrane protein YP_001850141.1 2236620 D 216594 CDS YP_001850142.1 183981851 6226097 2237857..2239020 1 NC_010612.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2239020 ispG 6226097 ispG Mycobacterium marinum M 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_001850142.1 2237857 D 216594 CDS YP_001850143.1 183981852 6226098 2239072..2239926 1 NC_010612.1 hypothetical protein 2239926 6226098 MMAR_1839 Mycobacterium marinum M hypothetical protein YP_001850143.1 2239072 D 216594 CDS YP_001850144.1 183981853 6226099 2240037..2241851 1 NC_010612.1 function unknown, possibly involved in cell wall biosynthesis; penicillin-binding lipoprotein 2241851 6226099 MMAR_1840 Mycobacterium marinum M penicillin-binding lipoprotein YP_001850144.1 2240037 D 216594 CDS YP_001850145.1 183981854 6226100 2241927..2242547 1 NC_010612.1 hypothetical protein 2242547 6226100 MMAR_1841 Mycobacterium marinum M hypothetical protein YP_001850145.1 2241927 D 216594 CDS YP_001850146.1 183981855 6226101 2242652..2243509 1 NC_010612.1 removes the amino-terminal methionine from nascent proteins [catalytic activity: L-methionylpeptide + H(2)O = L-methionine + peptide]; methionine aminopeptidase MapB 2243509 mapB 6226101 mapB Mycobacterium marinum M methionine aminopeptidase MapB YP_001850146.1 2242652 D 216594 CDS YP_001850147.1 183981856 6226102 2243719..2244270 1 NC_010612.1 hypothetical protein 2244270 6226102 MMAR_1843 Mycobacterium marinum M hypothetical protein YP_001850147.1 2243719 D 216594 CDS YP_001850148.1 183981857 6226103 2244403..2245140 1 NC_010612.1 function unknown, probably involved in cellular metabolism; amidotransferase 2245140 6226103 MMAR_1844 Mycobacterium marinum M amidotransferase YP_001850148.1 2244403 D 216594 CDS YP_001850149.1 183981858 6226104 complement(2245209..2246177) 1 NC_010612.1 PPE family protein 2246177 6226104 MMAR_1845 Mycobacterium marinum M PPE family protein YP_001850149.1 2245209 R 216594 CDS YP_001850150.1 183981859 6226105 complement(2246459..2247007) 1 NC_010612.1 hypothetical protein 2247007 6226105 MMAR_1846 Mycobacterium marinum M hypothetical protein YP_001850150.1 2246459 R 216594 CDS YP_001850151.1 183981860 6226106 complement(2247062..2248228) 1 NC_010612.1 PPE family protein 2248228 6226106 MMAR_1847 Mycobacterium marinum M PPE family protein YP_001850151.1 2247062 R 216594 CDS YP_001850152.1 183981861 6226107 complement(2248468..2248899) 1 NC_010612.1 hypothetical protein 2248899 6226107 MMAR_1848 Mycobacterium marinum M hypothetical protein YP_001850152.1 2248468 R 216594 CDS YP_001850153.1 183981862 6226108 complement(2249008..2250264) 1 NC_010612.1 PPE family protein 2250264 6226108 MMAR_1849 Mycobacterium marinum M PPE family protein YP_001850153.1 2249008 R 216594 CDS YP_001850154.1 183981863 6226109 complement(2251077..2253656) 1 NC_010612.1 PE-PGRS family protein 2253656 6226109 MMAR_1850 Mycobacterium marinum M PE-PGRS family protein YP_001850154.1 2251077 R 216594 CDS YP_001850155.1 183981864 6226110 complement(2253993..2256578) 1 NC_010612.1 PE-PGRS family protein 2256578 6226110 MMAR_1851 Mycobacterium marinum M PE-PGRS family protein YP_001850155.1 2253993 R 216594 CDS YP_001850156.1 183981865 6226111 complement(2256806..2259250) 1 NC_010612.1 could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase 2259250 bioF2_3 6226111 bioF2_3 Mycobacterium marinum M 8-amino-7-oxononanoate synthase YP_001850156.1 2256806 R 216594 CDS YP_001850157.1 183981866 6226112 complement(2259311..2259745) 1 NC_010612.1 hypothetical protein 2259745 6226112 MMAR_1853 Mycobacterium marinum M hypothetical protein YP_001850157.1 2259311 R 216594 CDS YP_001850158.1 183981867 6226113 complement(2260030..2261445) 1 NC_010612.1 involved in chorismate biosynthesis; 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase 2261445 aroG_1 6226113 aroG_1 Mycobacterium marinum M 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase YP_001850158.1 2260030 R 216594 CDS YP_001850159.1 183981868 6226114 complement(2262180..2263292) 1 NC_010612.1 hypothetical protein 2263292 6226114 MMAR_1855 Mycobacterium marinum M hypothetical protein YP_001850159.1 2262180 R 216594 CDS YP_001850160.1 183981869 6226115 complement(2263314..2264063) 1 NC_010612.1 hypothetical protein 2264063 6226115 MMAR_1856 Mycobacterium marinum M hypothetical protein YP_001850160.1 2263314 R 216594 CDS YP_001850161.1 183981870 6226116 complement(2264067..2265215) 1 NC_010612.1 HypD is involved in hydrogenase formation. it contains many possible metal binding residues, which may bind to nickel; hydrogenase-forming protein, HypD 2265215 hypD 6226116 hypD Mycobacterium marinum M hydrogenase-forming protein, HypD YP_001850161.1 2264067 R 216594 CDS YP_001850162.1 183981871 6226117 complement(2265227..2265499) 1 NC_010612.1 chaperone function in the formation of hydrogenase; hydrogenase maturation factor, HypC 2265499 hypC 6226117 hypC Mycobacterium marinum M hydrogenase maturation factor, HypC YP_001850162.1 2265227 R 216594 CDS YP_001850163.1 183981872 6226118 complement(2265522..2266634) 1 NC_010612.1 chaperone function in the formation of hydrogenase; hydrogenase maturation factor, HypE 2266634 hypE 6226118 hypE Mycobacterium marinum M hydrogenase maturation factor, HypE YP_001850163.1 2265522 R 216594 CDS YP_001850164.1 183981873 6226119 complement(2266631..2267305) 1 NC_010612.1 putative sugar phosphate isomerase 2267305 6226119 MMAR_1860 Mycobacterium marinum M putative sugar phosphate isomerase YP_001850164.1 2266631 R 216594 CDS YP_001850165.1 183981874 6226120 complement(2267302..2268024) 1 NC_010612.1 hypothetical protein 2268024 6226120 MMAR_1861 Mycobacterium marinum M hypothetical protein YP_001850165.1 2267302 R 216594 CDS YP_001850166.1 183981875 6226121 complement(2268021..2270411) 1 NC_010612.1 HypF participates in the maturation of HupSL and the HupUV proteins; hydrogenase maturation factor, HypF 2270411 hypF 6226121 hypF Mycobacterium marinum M hydrogenase maturation factor, HypF YP_001850166.1 2268021 R 216594 CDS YP_001850167.1 183981876 6226122 complement(2270413..2270676) 1 NC_010612.1 function unknown chaperone role, possibly in hydrogenase formation; HupF/HypC family protein 2270676 6226122 MMAR_1863 Mycobacterium marinum M HupF/HypC family protein YP_001850167.1 2270413 R 216594 CDS YP_001850168.1 183981877 6226123 complement(2270679..2271191) 1 NC_010612.1 metal-dependant hydrogenase maturating endopeptidase; nickel/iron hydrogenase maturation factor, HyaD 2271191 hyaD 6226123 hyaD Mycobacterium marinum M nickel/iron hydrogenase maturation factor, HyaD YP_001850168.1 2270679 R 216594 CDS YP_001850169.1 183981878 6226124 complement(2271314..2272672) 1 NC_010612.1 hypothetical protein 2272672 6226124 MMAR_1865 Mycobacterium marinum M hypothetical protein YP_001850169.1 2271314 R 216594 CDS YP_001850170.1 183981879 6226125 complement(2272669..2273328) 1 NC_010612.1 hypothetical protein 2273328 6226125 MMAR_1866 Mycobacterium marinum M hypothetical protein YP_001850170.1 2272669 R 216594 CDS YP_001850171.1 183981880 6226126 complement(2273325..2273951) 1 NC_010612.1 hypothetical protein 2273951 6226126 MMAR_1867 Mycobacterium marinum M hypothetical protein YP_001850171.1 2273325 R 216594 CDS YP_001850172.1 183981881 6226127 complement(2273948..2274922) 1 NC_010612.1 function unknown, but contains a thioredoxin-like domain; hypothetical protein 2274922 6226127 MMAR_1868 Mycobacterium marinum M hypothetical protein YP_001850172.1 2273948 R 216594 CDS YP_001850173.1 183981882 6226128 complement(2274926..2276725) 1 NC_010612.1 structural subunit of [nife] hydrogenase; nickel/iron-hydrogenase I large subunit, HyaB 2276725 hyaB 6226128 hyaB Mycobacterium marinum M nickel/iron-hydrogenase I large subunit, HyaB YP_001850173.1 2274926 R 216594 CDS YP_001850174.1 183981883 6226129 complement(2276775..2277830) 1 NC_010612.1 small structural subunit for [Ni/Fe] hydrogenase; nickel/iron-hydrogenase I small subunit, HyaA 2277830 hyaA 6226129 hyaA Mycobacterium marinum M nickel/iron-hydrogenase I small subunit, HyaA YP_001850174.1 2276775 R 216594 CDS YP_001850175.1 183981884 6226130 complement(2278150..2278917) 1 NC_010612.1 involved in regulation of expression and maturation of urease and hydrogenase; nickel cation-binding GTPase, HypB 2278917 hypB 6226130 hypB Mycobacterium marinum M nickel cation-binding GTPase, HypB YP_001850175.1 2278150 R 216594 CDS YP_001850176.1 183981885 6226131 complement(2278946..2279338) 1 NC_010612.1 involved in hydrogenase synthesis; hydrogenase expression/synthesis protein, HypA 2279338 hypA 6226131 hypA Mycobacterium marinum M hydrogenase expression/synthesis protein, HypA YP_001850176.1 2278946 R 216594 CDS YP_001850177.1 183981886 6226132 complement(2279373..2280491) 1 NC_010612.1 involved in nickel transport - part of the hydrogenase operon; high-affinity nickel permease, HoxN 2280491 hoxN 6226132 hoxN Mycobacterium marinum M high-affinity nickel permease, HoxN YP_001850177.1 2279373 R 216594 CDS YP_001850178.1 183981887 6226133 2280642..2281136 1 NC_010612.1 role in the regulation of uptake of iron, zinc and other metals; ferric uptake regulation protein FurB-like protein 2281136 6226133 MMAR_1874 Mycobacterium marinum M ferric uptake regulation protein FurB-like protein YP_001850178.1 2280642 D 216594 CDS YP_001850179.1 183981888 6226134 complement(2281143..2282522) 1 NC_010612.1 catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide; mycothione reductase 2282522 mtr 6226134 mtr Mycobacterium marinum M mycothione reductase YP_001850179.1 2281143 R 216594 CDS YP_001850180.1 183981889 6226135 2283063..2286119 1 NC_010612.1 lipid metabolism; long-chain acyl-CoA synthetase 2286119 6226135 MMAR_1876 Mycobacterium marinum M long-chain acyl-CoA synthetase YP_001850180.1 2283063 D 216594 CDS YP_001850181.1 183981890 6226136 complement(2286106..2289042) 1 NC_010612.1 thought to be involved in fatty acid transport; transmembrane transport protein MmpL 2289042 mmpL5_1 6226136 mmpL5_1 Mycobacterium marinum M transmembrane transport protein MmpL YP_001850181.1 2286106 R 216594 CDS YP_001850182.1 183981891 6226137 2289709..2290209 1 NC_010612.1 hypothetical protein 2290209 6226137 MMAR_1878 Mycobacterium marinum M hypothetical protein YP_001850182.1 2289709 D 216594 CDS YP_001850183.1 183981892 6226138 2290230..2291732 1 NC_010612.1 thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane; drug-transport integral membrane protein 2291732 6226138 MMAR_1879 Mycobacterium marinum M drug-transport integral membrane protein YP_001850183.1 2290230 D 216594 CDS YP_001850184.1 183981893 6226139 complement(2291709..2292731) 1 NC_010612.1 hypothetical protein 2292731 6226139 MMAR_1880 Mycobacterium marinum M hypothetical protein YP_001850184.1 2291709 R 216594 CDS YP_001850185.1 183981894 6226140 2292928..2294409 1 NC_010612.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2294409 mqo 6226140 mqo Mycobacterium marinum M malate:quinone oxidoreductase YP_001850185.1 2292928 D 216594 CDS YP_001850186.1 183981895 6226141 2294406..2294876 1 NC_010612.1 function unknown, predicted acyltransferase activity; acyltransferase ElaA 2294876 elaA 6226141 elaA Mycobacterium marinum M acyltransferase ElaA YP_001850186.1 2294406 D 216594 CDS YP_001850187.1 183981896 6226142 2294873..2296723 1 NC_010612.1 function unknown, possibly introduces a magnesium ion into specific substrate/compound; magnesium chelatase 2296723 6226142 MMAR_1883 Mycobacterium marinum M magnesium chelatase YP_001850187.1 2294873 D 216594 CDS YP_001850188.1 183981897 6226143 2296745..2297359 1 NC_010612.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 2297359 cobO 6226143 cobO Mycobacterium marinum M cob(I)yrinic acid a,c-diamide adenosyltransferase YP_001850188.1 2296745 D 216594 CDS YP_001850189.1 183981898 6226144 2297454..2298830 1 NC_010612.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid; cobyrinic acid a,c-diamide synthase 2298830 cobB 6226144 cobB Mycobacterium marinum M cobyrinic acid a,c-diamide synthase YP_001850189.1 2297454 D 216594 CDS YP_001850190.1 183981899 6226145 2298950..2300155 1 NC_010612.1 involved in the biosynthesis of siroheme and cobalamin [catalytic activity: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + sirohydrochlorin]. SAM-dependent methyl transferase that methylates uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. it catalyzes also the conversion of precorrin-2 into siroheme (consisting of an oxidation and fe(2+) chelation); multifunctional enzyme siroheme synthase CysG 2300155 cysG 6226145 cysG Mycobacterium marinum M multifunctional enzyme siroheme synthase CysG YP_001850190.1 2298950 D 216594 CDS YP_001850191.1 183981900 6226146 2300189..2301781 1 NC_010612.1 thought to be involved in transport of undeterminated substrate (possibly drug) across the membrane (export): so responsible for the translocation of the substrate across the membrane; integral membrane efflux protein EfpA 2301781 efpA 6226146 efpA Mycobacterium marinum M integral membrane efflux protein EfpA YP_001850191.1 2300189 D 216594 CDS YP_001850192.1 183981901 6226147 2301888..2303636 1 NC_010612.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 2303636 proS 6226147 proS Mycobacterium marinum M prolyl-tRNA synthetase YP_001850192.1 2301888 D 216594 CDS YP_001850193.1 183981902 6226148 complement(2303649..2304137) 1 NC_010612.1 hypothetical protein 2304137 6226148 MMAR_1889 Mycobacterium marinum M hypothetical protein YP_001850193.1 2303649 R 216594 CDS YP_001850194.1 183981903 6226149 complement(2304134..2304673) 1 NC_010612.1 hypothetical protein 2304673 6226149 MMAR_1890 Mycobacterium marinum M hypothetical protein YP_001850194.1 2304134 R 216594 CDS YP_001850195.1 183981904 6226150 2304889..2305422 1 NC_010612.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 2305422 6226150 MMAR_1891 Mycobacterium marinum M hypothetical protein YP_001850195.1 2304889 D 216594 CDS YP_001850196.1 183981905 6226151 2305419..2306462 1 NC_010612.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 2306462 nusA 6226151 nusA Mycobacterium marinum M transcription elongation factor NusA YP_001850196.1 2305419 D 216594 CDS YP_001850197.1 183981906 6226152 2306548..2306928 1 NC_010612.1 hypothetical protein 2306928 6226152 MMAR_1893 Mycobacterium marinum M hypothetical protein YP_001850197.1 2306548 D 216594 CDS YP_001850198.1 183981907 6226153 2306993..2309836 1 NC_010612.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 2309836 infB 6226153 infB Mycobacterium marinum M translation initiation factor IF-2 YP_001850198.1 2306993 D 216594 CDS YP_001850199.1 183981908 6226154 2309849..2310376 1 NC_010612.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 2310376 rbfA 6226154 rbfA Mycobacterium marinum M ribosome-binding factor A YP_001850199.1 2309849 D 216594 CDS YP_001850200.1 183981909 6226155 2310381..2311355 1 NC_010612.1 hypothetical protein 2311355 6226155 MMAR_1896 Mycobacterium marinum M hypothetical protein YP_001850200.1 2310381 D 216594 CDS YP_001850201.1 183981910 6226156 2311371..2312708 1 NC_010612.1 function unknown, induction by DNA damage; DNA-damage-inducible protein F DinF 2312708 dinF 6226156 dinF Mycobacterium marinum M DNA-damage-inducible protein F DinF YP_001850201.1 2311371 D 216594 CDS YP_001850202.1 183981911 6226157 2312773..2313672 1 NC_010612.1 involved in active transport of SN-glycerol-3- phosphate across the membrane (import). responsible for the translocation of the substrate across the membrane; SN-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA 2313672 ugpA 6226157 ugpA Mycobacterium marinum M SN-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA YP_001850202.1 2312773 D 216594 CDS YP_001850203.1 183981912 6226158 2313672..2314514 1 NC_010612.1 involved in active transport of SN-glycerol-3- phosphate across the membrane (import). responsible for the translocation of the substrate across the membrane; SN-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpE 2314514 ugpE 6226158 ugpE Mycobacterium marinum M SN-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpE YP_001850203.1 2313672 D 216594 CDS YP_001850204.1 183981913 6226159 2314521..2315834 1 NC_010612.1 involved in carbohydrate transport and metabolism; sugar ABC transporter 2315834 6226159 MMAR_1900 Mycobacterium marinum M sugar ABC transporter YP_001850204.1 2314521 D 216594 CDS YP_001850205.1 183981914 6226160 2315827..2316909 1 NC_010612.1 thought to be involved in active transport of sugar across the membrane (import). responsible for energy coupling to the transport system; sugar ABC transporter ATP-binding protein 2316909 6226160 MMAR_1901 Mycobacterium marinum M sugar ABC transporter ATP-binding protein YP_001850205.1 2315827 D 216594 CDS YP_001850206.1 183981915 6226161 complement(2316939..2317883) 1 NC_010612.1 enzyme that catalyse the reduction of disulphides by pyridine nucleotides through an enzyme disulphide and a flavin. in M. tuberculosis it is regulated by SigH. [catalytic activity: NADPH + oxidized thioredoxin = NADP(+) + reduced thioredoxin]; thioredoxin reductase TrxB2 2317883 trxB2_2 6226161 trxB2_2 Mycobacterium marinum M thioredoxin reductase TrxB2 YP_001850206.1 2316939 R 216594 CDS YP_001850207.1 183981916 6226162 complement(2317933..2318682) 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2318682 echA16_2 6226162 echA16_2 Mycobacterium marinum M enoyl-CoA hydratase YP_001850207.1 2317933 R 216594 CDS YP_001850208.1 183981917 6226163 2318976..2320172 1 NC_010612.1 PPE family protein 2320172 6226163 MMAR_1904 Mycobacterium marinum M PPE family protein YP_001850208.1 2318976 D 216594 CDS YP_001850209.1 183981918 6226164 2320305..2321480 1 NC_010612.1 PPE family protein 2321480 6226164 MMAR_1905 Mycobacterium marinum M PPE family protein YP_001850209.1 2320305 D 216594 CDS YP_001850210.1 183981919 6226165 2321518..2321793 1 NC_010612.1 hypothetical protein 2321793 6226165 MMAR_1906 Mycobacterium marinum M hypothetical protein YP_001850210.1 2321518 D 216594 CDS YP_001850211.1 183981920 6226166 2321790..2322335 1 NC_010612.1 hypothetical protein 2322335 6226166 MMAR_1907 Mycobacterium marinum M hypothetical protein YP_001850211.1 2321790 D 216594 CDS YP_001850212.1 183981921 6226167 complement(2322362..2325076) 1 NC_010612.1 function unknown but may be involved in trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway). seems to have additional alpha-glucosidase activity; trehalose or maltose hydrolase 2325076 6226167 MMAR_1908 Mycobacterium marinum M trehalose or maltose hydrolase YP_001850212.1 2322362 R 216594 CDS YP_001850213.1 183981922 6226168 complement(2325073..2325672) 1 NC_010612.1 hypothetical protein 2325672 6226168 MMAR_1909 Mycobacterium marinum M hypothetical protein YP_001850213.1 2325073 R 216594 CDS YP_001850214.1 183981923 6226169 complement(2325720..2327432) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hydrolase 2327432 6226169 MMAR_1910 Mycobacterium marinum M hydrolase YP_001850214.1 2325720 R 216594 CDS YP_001850215.1 183981924 6226170 complement(2327464..2328102) 1 NC_010612.1 hypothetical protein 2328102 6226170 MMAR_1911 Mycobacterium marinum M hypothetical protein YP_001850215.1 2327464 R 216594 CDS YP_001850216.1 183981925 6226171 2328233..2328544 1 NC_010612.1 hypothetical protein 2328544 6226171 MMAR_1912 Mycobacterium marinum M hypothetical protein YP_001850216.1 2328233 D 216594 CDS YP_001850217.1 183981926 6226172 2328535..2330223 1 NC_010612.1 hypothetical protein 2330223 6226172 MMAR_1913 Mycobacterium marinum M hypothetical protein YP_001850217.1 2328535 D 216594 CDS YP_001850218.1 183981927 6226173 2330223..2330795 1 NC_010612.1 lipoprotein LppV 2330795 lppV_1 6226173 lppV_1 Mycobacterium marinum M lipoprotein LppV YP_001850218.1 2330223 D 216594 CDS YP_001850219.1 183981928 6226174 2330886..2331851 1 NC_010612.1 hypothetical protein 2331851 6226174 MMAR_1915 Mycobacterium marinum M hypothetical protein YP_001850219.1 2330886 D 216594 CDS YP_001850220.1 183981929 6226175 2331848..2332531 1 NC_010612.1 phosphopantetheinyl transferase. secondary metabolites biosynthesis, transport, and catabolism. Sfp- type phosphopantetheinyl transferase; phosphopantetheinyl transferase, PptII 2332531 pptII 6226175 pptII Mycobacterium marinum M phosphopantetheinyl transferase, PptII YP_001850220.1 2331848 D 216594 CDS YP_001850221.1 183981930 6226176 2332528..2333433 1 NC_010612.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 2333433 truB 6226176 truB Mycobacterium marinum M tRNA pseudouridine synthase B YP_001850221.1 2332528 D 216594 CDS YP_001850222.1 183981931 6226177 2333540..2334742 1 NC_010612.1 possibly catalyzes the transfer of a great variety of lipids between membranes; lipid-transfer protein 2334742 ltp1 6226177 ltp1 Mycobacterium marinum M lipid-transfer protein YP_001850222.1 2333540 D 216594 CDS YP_001850223.1 183981932 6226178 2334771..2336009 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE21 2336009 fadE21 6226178 fadE21 Mycobacterium marinum M acyl-CoA dehydrogenase FadE21 YP_001850223.1 2334771 D 216594 CDS YP_001850224.1 183981933 6226179 complement(2336026..2336718) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional repressor SirR 2336718 sirR 6226179 sirR Mycobacterium marinum M transcriptional repressor SirR YP_001850224.1 2336026 R 216594 CDS YP_001850225.1 183981934 6226180 2336899..2337873 1 NC_010612.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 2337873 ribF 6226180 ribF Mycobacterium marinum M bifunctional riboflavin kinase/FMN adenylyltransferase YP_001850225.1 2336899 D 216594 CDS YP_001850226.1 183981935 6226181 2337999..2338268 1 NC_010612.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 2338268 rpsO 6226181 rpsO Mycobacterium marinum M 30S ribosomal protein S15 YP_001850226.1 2337999 D 216594 CDS YP_001850227.1 183981936 6226182 2338280..2338813 1 NC_010612.1 lipoprotein LppU 2338813 lppU 6226182 lppU Mycobacterium marinum M lipoprotein LppU YP_001850227.1 2338280 D 216594 CDS YP_001850228.1 183981937 6226183 2338848..2339246 1 NC_010612.1 hypothetical protein 2339246 6226183 MMAR_1924 Mycobacterium marinum M hypothetical protein YP_001850228.1 2338848 D 216594 CDS YP_001850229.1 183981938 6226184 2339617..2341905 1 NC_010612.1 involved in mRNA degradation. hydrolyses single- stranded polyribonucleotides processively in the 3' to 5' direction. involved in the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation [catalytic activity: RNA(n+1) + phosphate = RNA(N) + a nucleoside diphosphate]; polynucleotide phosphorylase/polyadenylase 2341905 gpsI 6226184 gpsI Mycobacterium marinum M polynucleotide phosphorylase/polyadenylase YP_001850229.1 2339617 D 216594 CDS YP_001850230.1 183981939 6226185 2341883..2343199 1 NC_010612.1 function unknown; possibly hydrolyzes peptides and/or proteins; zinc protease PepR 2343199 pepR 6226185 pepR Mycobacterium marinum M zinc protease PepR YP_001850230.1 2341883 D 216594 CDS YP_001850231.1 183981940 6226186 2343204..2344238 1 NC_010612.1 hypothetical protein 2344238 6226186 MMAR_1927 Mycobacterium marinum M hypothetical protein YP_001850231.1 2343204 D 216594 CDS YP_001850232.1 183981941 6226187 complement(2344315..2345430) 1 NC_010612.1 may play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [catalytic activity: L-alanine + H(2)O + NAD(+) = pyruvate + NH(3) + NADH]; secreted L-alanine dehydrogenase Ald (40 kDa antigen) 2345430 ald 6226187 ald Mycobacterium marinum M secreted L-alanine dehydrogenase Ald (40 kDa antigen) YP_001850232.1 2344315 R 216594 CDS YP_001850233.1 183981942 6226188 2345626..2346063 1 NC_010612.1 involved in transcriptional mechanism; Lrp/AsnC family transcriptional regulator 2346063 6226188 MMAR_1929 Mycobacterium marinum M Lrp/AsnC family transcriptional regulator YP_001850233.1 2345626 D 216594 CDS YP_001850234.1 183981943 6226189 2346092..2346556 1 NC_010612.1 hypothetical protein 2346556 6226189 MMAR_1930 Mycobacterium marinum M hypothetical protein YP_001850234.1 2346092 D 216594 CDS YP_001850235.1 183981944 6226190 2346661..2347578 1 NC_010612.1 hypothetical protein 2347578 6226190 MMAR_1931 Mycobacterium marinum M hypothetical protein YP_001850235.1 2346661 D 216594 CDS YP_001850236.1 183981945 6226191 2347584..2349344 1 NC_010612.1 thought to be involved in detoxification reactions following oxidative damage to lipids; short chain dehydrogenase 2349344 ephD_1 6226191 ephD_1 Mycobacterium marinum M short chain dehydrogenase YP_001850236.1 2347584 D 216594 CDS YP_001850237.1 183981946 6226192 2349358..2350440 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 2350440 6226192 MMAR_1933 Mycobacterium marinum M oxidoreductase YP_001850237.1 2349358 D 216594 CDS YP_001850238.1 183981947 6226193 complement(2350446..2351087) 1 NC_010612.1 hypothetical protein 2351087 6226193 MMAR_1934 Mycobacterium marinum M hypothetical protein YP_001850238.1 2350446 R 216594 CDS YP_001850239.1 183981948 6226194 2351211..2352236 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 2352236 6226194 MMAR_1935 Mycobacterium marinum M oxidoreductase YP_001850239.1 2351211 D 216594 CDS YP_001850240.1 183981949 6226195 2352242..2353330 1 NC_010612.1 hypothetical protein 2353330 6226195 MMAR_1936 Mycobacterium marinum M hypothetical protein YP_001850240.1 2352242 D 216594 CDS YP_001850241.1 183981950 6226196 complement(2353337..2354674) 1 NC_010612.1 hypothetical protein 2354674 6226196 MMAR_1937 Mycobacterium marinum M hypothetical protein YP_001850241.1 2353337 R 216594 CDS YP_001850242.1 183981951 6226197 2354778..2355515 1 NC_010612.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 2355515 dapB 6226197 dapB Mycobacterium marinum M dihydrodipicolinate reductase YP_001850242.1 2354778 D 216594 CDS YP_001850243.1 183981952 6226198 2355523..2355987 1 NC_010612.1 hypothetical protein 2355987 6226198 MMAR_1939 Mycobacterium marinum M hypothetical protein YP_001850243.1 2355523 D 216594 CDS YP_001850244.1 183981953 6226199 2355984..2356244 1 NC_010612.1 hypothetical protein 2356244 6226199 MMAR_1940 Mycobacterium marinum M hypothetical protein YP_001850244.1 2355984 D 216594 CDS YP_001850245.1 183981954 6226200 2356244..2356708 1 NC_010612.1 function unknown, contains a multimeric flavodoxin WrbA domain; hypothetical protein 2356708 6226200 MMAR_1941 Mycobacterium marinum M hypothetical protein YP_001850245.1 2356244 D 216594 CDS YP_001850246.1 183981955 6226201 2356705..2357718 1 NC_010612.1 hypothetical protein 2357718 6226201 MMAR_1942 Mycobacterium marinum M hypothetical protein YP_001850246.1 2356705 D 216594 CDS YP_001850247.1 183981956 6226202 2357777..2358646 1 NC_010612.1 hypothetical protein 2358646 6226202 MMAR_1943 Mycobacterium marinum M hypothetical protein YP_001850247.1 2357777 D 216594 CDS YP_001850248.1 183981957 6226203 2358681..2360135 1 NC_010612.1 hypothetical protein 2360135 6226203 MMAR_1944 Mycobacterium marinum M hypothetical protein YP_001850248.1 2358681 D 216594 CDS YP_001850249.1 183981958 6226204 complement(2359920..2361683) 1 NC_010612.1 function unknown, orthologues in mycobacteriophage; hypothetical protein 2361683 6226204 MMAR_1945 Mycobacterium marinum M hypothetical protein YP_001850249.1 2359920 R 216594 CDS YP_001850250.1 183981959 6226205 2361752..2362234 1 NC_010612.1 dehydrogenase 2362234 6226205 MMAR_1946 Mycobacterium marinum M dehydrogenase YP_001850250.1 2361752 D 216594 CDS YP_001850251.1 183981960 6226206 2362393..2363526 1 NC_010612.1 function unknown. may be involved in virulence; PPE family protein 2363526 6226206 MMAR_1947 Mycobacterium marinum M PPE family protein YP_001850251.1 2362393 D 216594 CDS YP_001850252.1 183981961 6226207 2363626..2365173 1 NC_010612.1 function unknown, but involved in lipid degradation; fatty acid-CoA ligase FadD13 2365173 fadD13_1 6226207 fadD13_1 Mycobacterium marinum M fatty acid-CoA ligase FadD13 YP_001850252.1 2363626 D 216594 CDS YP_001850253.1 183981962 6226208 2365472..2366275 1 NC_010612.1 PE family protein 2366275 6226208 MMAR_1949 Mycobacterium marinum M PE family protein YP_001850253.1 2365472 D 216594 CDS YP_001850254.1 183981963 6226209 2366345..2367526 1 NC_010612.1 PPE family protein 2367526 6226209 MMAR_1950 Mycobacterium marinum M PPE family protein YP_001850254.1 2366345 D 216594 CDS YP_001850255.1 183981964 6226210 2367558..2370791 1 NC_010612.1 involved in long-chain fatty acid synthesis (at the first step). carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + orthophosphate + carboxybiotin-carboxyl-carrier protein]; bifunctional protein acetyl-/propionyl-coenzyme A carboxylase alpha chain AccA3 2370791 accA3_1 6226210 accA3_1 Mycobacterium marinum M bifunctional protein acetyl-/propionyl-coenzyme A carboxylase alpha chain AccA3 YP_001850255.1 2367558 D 216594 CDS YP_001850256.1 183981965 6226211 complement(2370808..2371158) 1 NC_010612.1 PE-PGRS family protein 2371158 6226211 MMAR_5563 Mycobacterium marinum M PE-PGRS family protein YP_001850256.1 2370808 R 216594 CDS YP_001850257.1 183981966 6226212 2371280..2372062 1 NC_010612.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 2372062 fabG 6226212 fabG Mycobacterium marinum M 3-ketoacyl-ACP reductase YP_001850257.1 2371280 D 216594 CDS YP_001850258.1 183981967 6226213 2372059..2373252 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE34 2373252 fadE34_1 6226213 fadE34_1 Mycobacterium marinum M acyl-CoA dehydrogenase FadE34 YP_001850258.1 2372059 D 216594 CDS YP_001850259.1 183981968 6226214 2373249..2374352 1 NC_010612.1 function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase FadE18 2374352 fadE18_1 6226214 fadE18_1 Mycobacterium marinum M acyl-CoA dehydrogenase FadE18 YP_001850259.1 2373249 D 216594 CDS YP_001850260.1 183981969 6226215 complement(2374375..2375115) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; alanine rich hydrolase 2375115 6226215 MMAR_1955 Mycobacterium marinum M alanine rich hydrolase YP_001850260.1 2374375 R 216594 CDS YP_001850261.1 183981970 6226216 2375214..2376014 1 NC_010612.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 2376014 thyA 6226216 thyA Mycobacterium marinum M thymidylate synthase YP_001850261.1 2375214 D 216594 CDS YP_001850262.1 183981971 6226217 2376022..2376519 1 NC_010612.1 essential step for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dump to dTMP [catalytic activity: 5,6,7,8- tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH]; dihydrofolate reductase DfrA 2376519 dfrA 6226217 dfrA Mycobacterium marinum M dihydrofolate reductase DfrA YP_001850262.1 2376022 D 216594 CDS YP_001850263.1 183981972 6226218 2376516..2377730 1 NC_010612.1 hypothetical protein 2377730 6226218 MMAR_1958 Mycobacterium marinum M hypothetical protein YP_001850263.1 2376516 D 216594 CDS YP_001850264.1 183981973 6226219 2377730..2379184 1 NC_010612.1 implicated in methylation of DNA. component of type I restriction/modification system. it is possible that the M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of bipartite DNA recognition sequence; type I restriction/modification system DNA methylase HsdM 2379184 hsdM 6226219 hsdM Mycobacterium marinum M type I restriction/modification system DNA methylase HsdM YP_001850264.1 2377730 D 216594 CDS YP_001850265.1 183981974 6226220 2379181..2380266 1 NC_010612.1 implicated in restriction/modification of DNA. component of type I restriction/modification system. it is thought that the M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of bipartite DNA recognition sequence; type I restriction/modification system specificity determinant HsdS (S protein) 2380266 hsdS 6226220 hsdS Mycobacterium marinum M type I restriction/modification system specificity determinant HsdS (S protein) YP_001850265.1 2379181 D 216594 CDS YP_001850266.1 183981975 6226221 2380277..2381029 1 NC_010612.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 2381029 thyX 6226221 thyX Mycobacterium marinum M FAD-dependent thymidylate synthase YP_001850266.1 2380277 D 216594 CDS YP_001850267.1 183981976 6226222 2381147..2382049 1 NC_010612.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2382049 dapA 6226222 dapA Mycobacterium marinum M dihydrodipicolinate synthase YP_001850267.1 2381147 D 216594 CDS YP_001850268.1 183981977 6226223 2382069..2383745 1 NC_010612.1 function unknown, belongs to the metallo-beta- lactamase superfamily; hydrolase 2383745 6226223 MMAR_1963 Mycobacterium marinum M hydrolase YP_001850268.1 2382069 D 216594 CDS YP_001850269.1 183981978 6226224 complement(2383769..2384641) 1 NC_010612.1 function unknown domain identity suggests this is a methylase involved in secondary metabolism (polyketides); O-methyltransferase 2384641 6226224 MMAR_1964 Mycobacterium marinum M O-methyltransferase YP_001850269.1 2383769 R 216594 CDS YP_001850270.1 183981979 6226225 complement(2384645..2385478) 1 NC_010612.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 2385478 fabG 6226225 fabG Mycobacterium marinum M 3-ketoacyl-ACP reductase YP_001850270.1 2384645 R 216594 CDS YP_001850271.1 183981980 6226226 complement(2385478..2385789) 1 NC_010612.1 hypothetical protein 2385789 6226226 MMAR_1966 Mycobacterium marinum M hypothetical protein YP_001850271.1 2385478 R 216594 CDS YP_001850272.1 183981981 6226227 2385969..2388578 1 NC_010612.1 possibly involved in cell division processes; cell division transmembrane protein FtsK 2388578 ftsK 6226227 ftsK Mycobacterium marinum M cell division transmembrane protein FtsK YP_001850272.1 2385969 D 216594 CDS YP_001850273.1 183981982 6226228 complement(2388590..2389114) 1 NC_010612.1 catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; N-acetylglutamate synthase 2389114 6226228 MMAR_1968 Mycobacterium marinum M N-acetylglutamate synthase YP_001850273.1 2388590 R 216594 CDS YP_001850274.1 183981983 6226229 2389199..2389768 1 NC_010612.1 involved in acidic phospholipid biosynthesis. this protein probably catalyzes the committed step to the synthesis of the acidic phospholipids [catalytic activity: CDP-diacylglycerol + glycerol-3-phosphate = CMP + 3-(3- phosphatidyl)-glycerol 1-phosphate]; PGP synthase PgsA3 2389768 pgsA3 6226229 pgsA3 Mycobacterium marinum M PGP synthase PgsA3 YP_001850274.1 2389199 D 216594 CDS YP_001850275.1 183981984 6226230 2389908..2390234 1 NC_010612.1 possibly involved in transcriptional mechanism; transcriptional regulatory protein 2390234 6226230 MMAR_1970 Mycobacterium marinum M transcriptional regulatory protein YP_001850275.1 2389908 D 216594 CDS YP_001850276.1 183981985 6226231 2390393..2391208 1 NC_010612.1 function unknown but domain identity to COG1842, PspA, phage shock protein a (IM30), suppresses sigma54- dependent transcription; hypothetical protein 2391208 6226231 MMAR_1971 Mycobacterium marinum M hypothetical protein YP_001850276.1 2390393 D 216594 CDS YP_001850277.1 183981986 6226232 2391224..2392039 1 NC_010612.1 hypothetical protein 2392039 6226232 MMAR_1972 Mycobacterium marinum M hypothetical protein YP_001850277.1 2391224 D 216594 CDS YP_001850278.1 183981987 6226233 complement(2392048..2392488) 1 NC_010612.1 function unknown but contains a lima, limonene-1,2- epoxide hydrolase domain; hypothetical protein 2392488 6226233 MMAR_1973 Mycobacterium marinum M hypothetical protein YP_001850278.1 2392048 R 216594 CDS YP_001850279.1 183981988 6226234 2392584..2393750 1 NC_010612.1 function unknown, probably involved in cellular metabolism; glycosyl transferase family protein 2393750 6226234 MMAR_1974 Mycobacterium marinum M glycosyl transferase family protein YP_001850279.1 2392584 D 216594 CDS YP_001850280.1 183981989 6226235 2393774..2393980 1 NC_010612.1 hypothetical protein 2393980 6226235 MMAR_1975 Mycobacterium marinum M hypothetical protein YP_001850280.1 2393774 D 216594 CDS YP_001850281.1 183981990 6226236 complement(2393993..2394718) 1 NC_010612.1 hypothetical protein 2394718 6226236 MMAR_1976 Mycobacterium marinum M hypothetical protein YP_001850281.1 2393993 R 216594 CDS YP_001850282.1 183981991 6226237 2394811..2395851 1 NC_010612.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 2395851 recA 6226237 recA Mycobacterium marinum M recombinase A YP_001850282.1 2394811 D 216594 CDS YP_001850283.1 183981992 6226238 2395817..2396338 1 NC_010612.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2396338 recX 6226238 recX Mycobacterium marinum M recombination regulator RecX YP_001850283.1 2395817 D 216594 CDS YP_001850284.1 183981993 6226239 2396413..2398011 1 NC_010612.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 2398011 6226239 MMAR_1979 Mycobacterium marinum M (dimethylallyl)adenosine tRNA methylthiotransferase YP_001850284.1 2396413 D 216594 CDS YP_001850285.1 183981994 6226240 2398008..2398619 1 NC_010612.1 hypothetical protein 2398619 6226240 MMAR_1980 Mycobacterium marinum M hypothetical protein YP_001850285.1 2398008 D 216594 CDS YP_001850286.1 183981995 6226241 complement(2398616..2399965) 1 NC_010612.1 hypothetical protein 2399965 6226241 MMAR_1981 Mycobacterium marinum M hypothetical protein YP_001850286.1 2398616 R 216594 CDS YP_001850287.1 183981996 6226242 complement(2400206..2402011) 1 NC_010612.1 involved in signal transduction (via phosphorylation). thought to be involved in arabinan metabolism, phosphorylating perhaps EmbR [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 2402011 pknH_2 6226242 pknH_2 Mycobacterium marinum M Ser/Thr protein kinase YP_001850287.1 2400206 R 216594 CDS YP_001850288.1 183981997 6226243 2402475..2403374 1 NC_010612.1 hypothetical protein 2403374 6226243 MMAR_1983 Mycobacterium marinum M hypothetical protein YP_001850288.1 2402475 D 216594 CDS YP_001850289.1 183981998 6226244 2403594..2404571 1 NC_010612.1 hypothetical protein 2404571 6226244 MMAR_1984 Mycobacterium marinum M hypothetical protein YP_001850289.1 2403594 D 216594 CDS YP_001850290.1 183981999 6226245 2404618..2405313 1 NC_010612.1 hypothetical protein 2405313 6226245 MMAR_1985 Mycobacterium marinum M hypothetical protein YP_001850290.1 2404618 D 216594 CDS YP_001850291.1 183982000 6226246 2405310..2406254 1 NC_010612.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 2406254 miaA 6226246 miaA Mycobacterium marinum M tRNA delta(2)-isopentenylpyrophosphate transferase YP_001850291.1 2405310 D 216594 CDS YP_001850292.1 183982001 6226247 2406259..2407131 1 NC_010612.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 2407131 dapF 6226247 dapF Mycobacterium marinum M diaminopimelate epimerase YP_001850292.1 2406259 D 216594 CDS YP_001850293.1 183982002 6226248 2407178..2408692 1 NC_010612.1 possibly a GTPase, modulating activity of HflK and HflC proteins; GTP-binding protein HflX 2408692 hflX 6226248 hflX Mycobacterium marinum M GTP-binding protein HflX YP_001850293.1 2407178 D 216594 CDS YP_001850294.1 183982003 6226249 2408836..2409996 1 NC_010612.1 function unknown, but involved in lipid metabolism; acyl-CoA dehydrogenase FadE20 2409996 fadE20 6226249 fadE20 Mycobacterium marinum M acyl-CoA dehydrogenase FadE20 YP_001850294.1 2408836 D 216594 CDS YP_001850295.1 183982004 6226250 complement(2410025..2411206) 1 NC_010612.1 hypothetical protein 2411206 6226250 MMAR_1990 Mycobacterium marinum M hypothetical protein YP_001850295.1 2410025 R 216594 CDS YP_001850296.1 183982005 6226251 2411501..2413801 1 NC_010612.1 hypothetical protein 2413801 6226251 MMAR_1991 Mycobacterium marinum M hypothetical protein YP_001850296.1 2411501 D 216594 CDS YP_001850297.1 183982006 6226252 complement(2413842..2414576) 1 NC_010612.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 2414576 lexA 6226252 lexA Mycobacterium marinum M LexA repressor YP_001850297.1 2413842 R 216594 CDS YP_001850298.1 183982007 6226253 2414884..2415426 1 NC_010612.1 in M. tuberculosis H37Rv thought to be regulated by LexA; hypothetical protein 2415426 6226253 MMAR_1993 Mycobacterium marinum M hypothetical protein YP_001850298.1 2414884 D 216594 CDS YP_001850299.1 183982008 6226254 2415436..2416053 1 NC_010612.1 membrane-associated regulatory protein 2416053 6226254 MMAR_1994 Mycobacterium marinum M membrane-associated regulatory protein YP_001850299.1 2415436 D 216594 CDS YP_001850300.1 183982009 6226255 2416082..2416567 1 NC_010612.1 hypothetical protein 2416567 6226255 MMAR_1995 Mycobacterium marinum M hypothetical protein YP_001850300.1 2416082 D 216594 CDS YP_001850301.1 183982010 6226256 complement(2416577..2417263) 1 NC_010612.1 function unknown but contains identity to an epimerase involved in phenazine biosynthesis; hypothetical protein 2417263 6226256 MMAR_1996 Mycobacterium marinum M hypothetical protein YP_001850301.1 2416577 R 216594 CDS YP_001850302.1 183982011 6226257 complement(2417309..2418334) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hydrolase 2418334 6226257 MMAR_1997 Mycobacterium marinum M hydrolase YP_001850302.1 2417309 R 216594 CDS YP_001850303.1 183982012 6226258 complement(2418383..2419360) 1 NC_010612.1 hypothetical protein 2419360 6226258 MMAR_1998 Mycobacterium marinum M hypothetical protein YP_001850303.1 2418383 R 216594 CDS YP_001850304.1 183982013 6226259 2419604..2420431 1 NC_010612.1 function unknown but contains weak similarity to V8- like Glu-specific endopeptidases involved in amino acid transport and metabolism; hypothetical protein 2420431 6226259 MMAR_1999 Mycobacterium marinum M hypothetical protein YP_001850304.1 2419604 D 216594 CDS YP_001850305.1 183982014 6226260 complement(2420439..2421854) 1 NC_010612.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 2421854 sthA 6226260 sthA Mycobacterium marinum M soluble pyridine nucleotide transhydrogenase YP_001850305.1 2420439 R 216594 CDS YP_001850306.1 183982015 6226261 2421960..2423027 1 NC_010612.1 hypothetical protein 2423027 6226261 MMAR_2001 Mycobacterium marinum M hypothetical protein YP_001850306.1 2421960 D 216594 CDS YP_001850307.1 183982016 6226262 complement(2423029..2423721) 1 NC_010612.1 transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene; iron-dependent repressor and activator IdeR 2423721 ideR 6226262 ideR Mycobacterium marinum M iron-dependent repressor and activator IdeR YP_001850307.1 2423029 R 216594 CDS YP_001850308.1 183982017 6226263 complement(2423873..2424874) 1 NC_010612.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB 2424874 sigB 6226263 sigB Mycobacterium marinum M RNA polymerase sigma factor SigB YP_001850308.1 2423873 R 216594 CDS YP_001850309.1 183982018 6226264 complement(2425009..2425419) 1 NC_010612.1 hypothetical protein 2425419 6226264 MMAR_2004 Mycobacterium marinum M hypothetical protein YP_001850309.1 2425009 R 216594 CDS YP_001850310.1 183982019 6226265 2425474..2425722 1 NC_010612.1 hypothetical protein 2425722 6226265 MMAR_2005 Mycobacterium marinum M hypothetical protein YP_001850310.1 2425474 D 216594 CDS YP_001850311.1 183982020 6226266 complement(2425723..2426697) 1 NC_010612.1 hypothetical protein 2426697 6226266 MMAR_2006 Mycobacterium marinum M hypothetical protein YP_001850311.1 2425723 R 216594 CDS YP_001850312.1 183982021 6226267 complement(2426763..2426948) 1 NC_010612.1 hypothetical protein 2426948 6226267 MMAR_2007 Mycobacterium marinum M hypothetical protein YP_001850312.1 2426763 R 216594 CDS YP_001850313.1 183982022 6226268 2427075..2427455 1 NC_010612.1 hypothetical protein 2427455 6226268 MMAR_2008 Mycobacterium marinum M hypothetical protein YP_001850313.1 2427075 D 216594 CDS YP_001850314.1 183982023 6226269 complement(2427383..2427826) 1 NC_010612.1 function unknown but contains pfam01042 domain, endoribonuclease L-PSP. endoribonuclease active on single- stranded mRNA. inhibits protein synthesis by cleavage of mRNA. previously thought to inhibit protein synthesis initiation. this protein may also be involved I; hypothetical protein 2427826 6226269 MMAR_2009 Mycobacterium marinum M hypothetical protein YP_001850314.1 2427383 R 216594 CDS YP_001850315.1 183982024 6226270 complement(2427932..2429896) 1 NC_010612.1 PE-PGRS family protein 2429896 6226270 MMAR_2010 Mycobacterium marinum M PE-PGRS family protein YP_001850315.1 2427932 R 216594 CDS YP_001850316.1 183982025 6226271 complement(2430106..2431611) 1 NC_010612.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor 2431611 sigA 6226271 sigA Mycobacterium marinum M RNA polymerase sigma factor YP_001850316.1 2430106 R 216594 CDS YP_001850317.1 183982026 6226272 complement(2431790..2432584) 1 NC_010612.1 catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. GTP, UTP and CTP can replace ATP as phosphoryl donor [catalytic activity: (phosphate)(N) + d-glucose = (phosphate)(N-1) + d-glucose 6-phosphate]; polyphosphate glucokinase PpgK 2432584 ppgK 6226272 ppgK Mycobacterium marinum M polyphosphate glucokinase PpgK YP_001850317.1 2431790 R 216594 CDS YP_001850318.1 183982027 6226273 2432706..2433575 1 NC_010612.1 in E. coli, SuhB mutation (SuhB2) enhances the synthesis of sigma(32) and suppresses temperature- sensitive growth of the RpoH15 mutant. may affect some step(S) of protein synthesis by facilitating the function of GroE or other heat shock proteins; extragenic suppressor protein SuhB 2433575 suhB 6226273 suhB Mycobacterium marinum M extragenic suppressor protein SuhB YP_001850318.1 2432706 D 216594 CDS YP_001850319.1 183982028 6226274 complement(2433581..2434234) 1 NC_010612.1 hypothetical protein 2434234 6226274 MMAR_2014 Mycobacterium marinum M hypothetical protein YP_001850319.1 2433581 R 216594 CDS YP_001850320.1 183982029 6226275 2434418..2434720 1 NC_010612.1 hypothetical protein 2434720 6226275 MMAR_2015 Mycobacterium marinum M hypothetical protein YP_001850320.1 2434418 D 216594 CDS YP_001850321.1 183982030 6226276 complement(2434725..2435204) 1 NC_010612.1 hypothetical protein 2435204 6226276 MMAR_2016 Mycobacterium marinum M hypothetical protein YP_001850321.1 2434725 R 216594 CDS YP_001850322.1 183982031 6226277 2435230..2435694 1 NC_010612.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 2435694 dut 6226277 dut Mycobacterium marinum M deoxyuridine 5'-triphosphate nucleotidohydrolase YP_001850322.1 2435230 D 216594 CDS YP_001850323.1 183982032 6226278 2435694..2436437 1 NC_010612.1 hypothetical protein 2436437 6226278 MMAR_2018 Mycobacterium marinum M hypothetical protein YP_001850323.1 2435694 D 216594 CDS YP_001850324.1 183982033 6226279 complement(2436451..2437170) 1 NC_010612.1 hypothetical protein 2437170 6226279 MMAR_2019 Mycobacterium marinum M hypothetical protein YP_001850324.1 2436451 R 216594 CDS YP_001850325.1 183982034 6226280 2437302..2437685 1 NC_010612.1 hypothetical protein 2437685 6226280 MMAR_2020 Mycobacterium marinum M hypothetical protein YP_001850325.1 2437302 D 216594 CDS YP_001850326.1 183982035 6226281 2437713..2438384 1 NC_010612.1 integral membrane alanine and leucine rich protein 2438384 6226281 MMAR_2021 Mycobacterium marinum M integral membrane alanine and leucine rich protein YP_001850326.1 2437713 D 216594 CDS YP_001850327.1 183982036 6226282 complement(2438603..2439265) 1 NC_010612.1 part of a potassium transport system; TRK system potassium uptake protein CeoC 2439265 ceoC 6226282 ceoC Mycobacterium marinum M TRK system potassium uptake protein CeoC YP_001850327.1 2438603 R 216594 CDS YP_001850328.1 183982037 6226283 complement(2439318..2440001) 1 NC_010612.1 part of a potassium transport system; TRK system potassium uptake protein CeoB 2440001 ceoB 6226283 ceoB Mycobacterium marinum M TRK system potassium uptake protein CeoB YP_001850328.1 2439318 R 216594 CDS YP_001850329.1 183982038 6226284 2440134..2442131 1 NC_010612.1 function unknown but domain identity suggests a role in amino acid transport; integral membrane alanine, valine and leucine rich protein 2442131 6226284 MMAR_2024 Mycobacterium marinum M integral membrane alanine, valine and leucine rich protein YP_001850329.1 2440134 D 216594 CDS YP_001850330.1 183982039 6226285 2442128..2443333 1 NC_010612.1 function unknown but domain identity suggests this CDS encodes TrmA, a protein related to tRNA (uracil-5-)- methyltransferases; SAM-dependent methyltransferase 2443333 6226285 MMAR_2025 Mycobacterium marinum M SAM-dependent methyltransferase YP_001850330.1 2442128 D 216594 CDS YP_001850331.1 183982040 6226286 2443458..2444357 1 NC_010612.1 thought to be involved in active transport of unidentified antibiotic across the membrane (export): antibiotic resistance by an export mechanism. responsible for energy coupling to the transport system; antibiotic-transport ATP-binding protein ABC transporter 2444357 6226286 MMAR_2026 Mycobacterium marinum M antibiotic-transport ATP-binding protein ABC transporter YP_001850331.1 2443458 D 216594 CDS YP_001850332.1 183982041 6226287 2444354..2445064 1 NC_010612.1 thought to be involved in active transport of unidentified antibiotic across the membrane (export): antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; antibiotic ABC transporter integral membrane protein 2445064 6226287 MMAR_2027 Mycobacterium marinum M antibiotic ABC transporter integral membrane protein YP_001850332.1 2444354 D 216594 CDS YP_001850333.1 183982042 6226288 2445061..2445825 1 NC_010612.1 thought to be involved in active transport of unidentified antibiotic across the membrane (export): antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; antibiotic ABC transporter integral membrane protein 2445825 6226288 MMAR_2028 Mycobacterium marinum M antibiotic ABC transporter integral membrane protein YP_001850333.1 2445061 D 216594 CDS YP_001850334.1 183982043 6226289 complement(2445831..2447117) 1 NC_010612.1 thought to be involved in transport of arsenical compounds across the membrane (export): arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; arsenic-transport integral membrane protein ArsB1 2447117 arsB1 6226289 arsB1 Mycobacterium marinum M arsenic-transport integral membrane protein ArsB1 YP_001850334.1 2445831 R 216594 CDS YP_001850335.1 183982044 6226290 complement(2447156..2448445) 1 NC_010612.1 thought to be involved in active transport of arsenical compounds across the membrane (export): arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; arsenic-transport integral membrane protein ArsA 2448445 arsA 6226290 arsA Mycobacterium marinum M arsenic-transport integral membrane protein ArsA YP_001850335.1 2447156 R 216594 CDS YP_001850336.1 183982045 6226291 complement(2448501..2448944) 1 NC_010612.1 hypothetical protein 2448944 6226291 MMAR_2031 Mycobacterium marinum M hypothetical protein YP_001850336.1 2448501 R 216594 CDS YP_001850337.1 183982046 6226292 2449148..2451061 1 NC_010612.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 2451061 dxs1 6226292 dxs1 Mycobacterium marinum M 1-deoxy-D-xylulose-5-phosphate synthase YP_001850337.1 2449148 D 216594 CDS YP_001850338.1 183982047 6226293 complement(2451104..2454973) 1 NC_010612.1 PE-PGRS family protein 2454973 6226293 MMAR_2033 Mycobacterium marinum M PE-PGRS family protein YP_001850338.1 2451104 R 216594 CDS YP_001850339.1 183982048 6226295 complement(2456511..2457818) 1 NC_010612.1 hypothetical protein 2457818 6226295 MMAR_2035 Mycobacterium marinum M hypothetical protein YP_001850339.1 2456511 R 216594 CDS YP_001850340.1 183982049 6226296 complement(2457820..2458401) 1 NC_010612.1 hypothetical protein 2458401 6226296 MMAR_2036 Mycobacterium marinum M hypothetical protein YP_001850340.1 2457820 R 216594 CDS YP_001850341.1 183982050 6226297 complement(2458540..2459349) 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2459349 echA15 6226297 echA15 Mycobacterium marinum M enoyl-CoA hydratase YP_001850341.1 2458540 R 216594 CDS YP_001850342.1 183982051 6226298 2459472..2460533 1 NC_010612.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 2460533 hemE 6226298 hemE Mycobacterium marinum M uroporphyrinogen decarboxylase YP_001850342.1 2459472 D 216594 CDS YP_001850343.1 183982052 6226299 2460530..2461897 1 NC_010612.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase 2461897 hemY 6226299 hemY Mycobacterium marinum M protoporphyrinogen oxidase YP_001850343.1 2460530 D 216594 CDS YP_001850344.1 183982053 6226300 2461903..2462598 1 NC_010612.1 function unknown but contains identity to pfam06778, chlorite dismutase. this family contains chlorite dismutase enzymes of bacterial and archaeal origin. this enzyme catalyses the disproportionation of chlorite into chloride and oxygen. note that many family memb; hypothetical protein 2462598 6226300 MMAR_2040 Mycobacterium marinum M hypothetical protein YP_001850344.1 2461903 D 216594 CDS YP_001850345.1 183982054 6226301 2462595..2463344 1 NC_010612.1 methyltransferase 2463344 6226301 MMAR_2041 Mycobacterium marinum M methyltransferase YP_001850345.1 2462595 D 216594 CDS YP_001850346.1 183982055 6226302 complement(2463351..2463791) 1 NC_010612.1 function unknown but contains a SelR domain. these family of reductases are involved in the reduction of methionine sulfoxides in proteins; hypothetical protein 2463791 6226302 MMAR_2042 Mycobacterium marinum M hypothetical protein YP_001850346.1 2463351 R 216594 CDS YP_001850347.1 183982056 6226303 complement(2463788..2465098) 1 NC_010612.1 transmembrane protein 2465098 6226303 MMAR_2043 Mycobacterium marinum M transmembrane protein YP_001850347.1 2463788 R 216594 CDS YP_001850348.1 183982057 6226304 complement(2465118..2466689) 1 NC_010612.1 hypothetical protein 2466689 6226304 MMAR_2044 Mycobacterium marinum M hypothetical protein YP_001850348.1 2465118 R 216594 CDS YP_001850349.1 183982058 6226305 complement(2466738..2467520) 1 NC_010612.1 involved in riboflavin biosynthesis (at the second and third steps). converts 2,5-diamino-6-(ribosylamino)- 4(3H)-pyrimidinone 5'-phosphate into 5-amino-6- (ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate [catalytic activity 1: 2,5-diamino-6-hydroxy-4-(5- phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5- phosphoribosylamino)uracil + NH(3)] [catalytic activity 2: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5- amino-6-(5-phosphoribosylamino)uracil + NADPH]; hypothetical protein 2467520 ribD 6226305 ribD Mycobacterium marinum M hypothetical protein YP_001850349.1 2466738 R 216594 CDS YP_001850350.1 183982059 6226306 2467578..2468654 1 NC_010612.1 hypothetical protein 2468654 6226306 MMAR_2046 Mycobacterium marinum M hypothetical protein YP_001850350.1 2467578 D 216594 CDS YP_001850351.1 183982060 6226307 complement(2468632..2469090) 1 NC_010612.1 hypothetical protein 2469090 6226307 MMAR_5575 Mycobacterium marinum M hypothetical protein YP_001850351.1 2468632 R 216594 CDS YP_001850352.1 183982061 6226308 complement(2469137..2469697) 1 NC_010612.1 hypothetical protein 2469697 6226308 MMAR_2047 Mycobacterium marinum M hypothetical protein YP_001850352.1 2469137 R 216594 CDS YP_001850353.1 183982062 6226309 complement(2469776..2470519) 1 NC_010612.1 function unknown, possibly hydrolyzes peptides and/or proteins in presence of ATP; ATP-dependent protease ATP-binding subunit ClpC2 2470519 clpC2 6226309 clpC2 Mycobacterium marinum M ATP-dependent protease ATP-binding subunit ClpC2 YP_001850353.1 2469776 R 216594 CDS YP_001850354.1 183982063 6226310 2470627..2470950 1 NC_010612.1 hypothetical protein 2470950 6226310 MMAR_2049 Mycobacterium marinum M hypothetical protein YP_001850354.1 2470627 D 216594 CDS YP_001850355.1 183982064 6226311 2471004..2471963 1 NC_010612.1 function unknown but has domain identity with lysophospholipases; hypothetical protein 2471963 6226311 MMAR_2050 Mycobacterium marinum M hypothetical protein YP_001850355.1 2471004 D 216594 CDS YP_001850356.1 183982065 6226312 2471995..2473662 1 NC_010612.1 hypothetical protein 2473662 6226312 MMAR_2051 Mycobacterium marinum M hypothetical protein YP_001850356.1 2471995 D 216594 CDS YP_001850357.1 183982066 6226313 complement(2473640..2475040) 1 NC_010612.1 thought to be involved in transport of amino acid across the membrane; amino acid transporter 2475040 6226313 MMAR_2052 Mycobacterium marinum M amino acid transporter YP_001850357.1 2473640 R 216594 CDS YP_001850358.1 183982067 6226318 complement(2475782..2477995) 1 NC_010612.1 PE-PGRS family protein 2477995 6226318 MMAR_2053 Mycobacterium marinum M PE-PGRS family protein YP_001850358.1 2475782 R 216594 CDS YP_001850359.1 183982068 6226319 complement(2478535..2479350) 1 NC_010612.1 hypothetical protein 2479350 6226319 MMAR_2054 Mycobacterium marinum M hypothetical protein YP_001850359.1 2478535 R 216594 CDS YP_001850360.1 183982069 6226320 complement(2479478..2480995) 1 NC_010612.1 involved in transport of arsenic compounds across the membrane (export): arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; arsenic-transport integral membrane protein ArsC 2480995 arsC 6226320 arsC Mycobacterium marinum M arsenic-transport integral membrane protein ArsC YP_001850360.1 2479478 R 216594 CDS YP_001850361.1 183982070 6226321 complement(2480992..2481369) 1 NC_010612.1 involved in transcriptional mechanism; ArsR family transcriptional regulator 2481369 6226321 MMAR_2056 Mycobacterium marinum M ArsR family transcriptional regulator YP_001850361.1 2480992 R 216594 CDS YP_001850362.1 183982071 6226322 complement(2481449..2481919) 1 NC_010612.1 function unknown, in M. tuberculosis H37Rv this gene induced by cadmium (see hotter et al., 2001); hypothetical protein 2481919 cadI 6226322 cadI Mycobacterium marinum M hypothetical protein YP_001850362.1 2481449 R 216594 CDS YP_001850363.1 183982072 6226323 2482021..2482380 1 NC_010612.1 involved in transcriptional mechanism; ArsR family transcriptional regulator 2482380 6226323 MMAR_2058 Mycobacterium marinum M ArsR family transcriptional regulator YP_001850363.1 2482021 D 216594 CDS YP_001850364.1 183982073 6226324 2482478..2482768 1 NC_010612.1 hypothetical protein 2482768 6226324 MMAR_2059 Mycobacterium marinum M hypothetical protein YP_001850364.1 2482478 D 216594 CDS YP_001850365.1 183982074 6226325 2482811..2483758 1 NC_010612.1 it catalyses the conversion of hydrogen peroxide to water and molecular oxygen and is thus involved in the protection of cells from the toxic effects of peroxides; catalase 2483758 6226325 MMAR_2060 Mycobacterium marinum M catalase YP_001850365.1 2482811 D 216594 CDS YP_001850366.1 183982075 6226326 complement(2483778..2484218) 1 NC_010612.1 function unknown but contains identity with a pfam01740 STAS domain. the STAS (after sulphate transporter and antisigma factor antagonist) domain is found in the C terminal region of sulphate transporters and bacterial antisigma factor antagonists. it has been Sug; hypothetical protein 2484218 6226326 MMAR_2061 Mycobacterium marinum M hypothetical protein YP_001850366.1 2483778 R 216594 CDS YP_001850367.1 183982076 6226327 2484371..2484976 1 NC_010612.1 hypothetical protein 2484976 6226327 MMAR_2062 Mycobacterium marinum M hypothetical protein YP_001850367.1 2484371 D 216594 CDS YP_001850368.1 183982077 6226328 complement(2484987..2485643) 1 NC_010612.1 transmembrane protein DedA 2485643 dedA 6226328 dedA Mycobacterium marinum M transmembrane protein DedA YP_001850368.1 2484987 R 216594 CDS YP_001850369.1 183982078 6226329 2485875..2487512 1 NC_010612.1 function unknown, but involved in lipid degradation; fatty-acid-CoA ligase 2487512 6226329 MMAR_2064 Mycobacterium marinum M fatty-acid-CoA ligase YP_001850369.1 2485875 D 216594 CDS YP_001850370.1 183982079 6226330 complement(2487522..2488151) 1 NC_010612.1 role in resistance to chloramphenicol. modifies the primary (C-3) hydroxyl of the antibiotic; chloramphenicol 3-O-phosphotransferase 2488151 6226330 MMAR_2065 Mycobacterium marinum M chloramphenicol 3-O-phosphotransferase YP_001850370.1 2487522 R 216594 CDS YP_001850371.1 183982080 6226331 complement(2488603..2489106) 1 NC_010612.1 hypothetical protein 2489106 6226331 MMAR_2066 Mycobacterium marinum M hypothetical protein YP_001850371.1 2488603 R 216594 CDS YP_001850372.1 183982081 6226332 2489762..2492080 1 NC_010612.1 PE-PGRS family protein 2492080 6226332 MMAR_2067 Mycobacterium marinum M PE-PGRS family protein YP_001850372.1 2489762 D 216594 CDS YP_001850373.1 183982082 6226333 2492181..2492462 1 NC_010612.1 hypothetical protein 2492462 6226333 MMAR_2068 Mycobacterium marinum M hypothetical protein YP_001850373.1 2492181 D 216594 CDS YP_001850374.1 183982083 6226334 complement(2492496..2493806) 1 NC_010612.1 function unknown but contains phosphoribosyltransferase domain; hypothetical protein 2493806 6226334 MMAR_2069 Mycobacterium marinum M hypothetical protein YP_001850374.1 2492496 R 216594 CDS YP_001850375.1 183982084 6226335 complement(2493906..2495030) 1 NC_010612.1 hypothetical protein 2495030 6226335 MMAR_2070 Mycobacterium marinum M hypothetical protein YP_001850375.1 2493906 R 216594 CDS YP_001850376.1 183982085 6226336 complement(2495093..2496958) 1 NC_010612.1 involved in lipid metabolism; long-chain-fatty-acid-CoA ligase, FadD11 2496958 fadD11_1 6226336 fadD11_1 Mycobacterium marinum M long-chain-fatty-acid-CoA ligase, FadD11 YP_001850376.1 2495093 R 216594 CDS YP_001850377.1 183982086 6226337 2497213..2498466 1 NC_010612.1 hypothetical protein 2498466 6226337 MMAR_2072 Mycobacterium marinum M hypothetical protein YP_001850377.1 2497213 D 216594 CDS YP_001850378.1 183982087 6226338 2498482..2499909 1 NC_010612.1 hypothetical protein 2499909 6226338 MMAR_2073 Mycobacterium marinum M hypothetical protein YP_001850378.1 2498482 D 216594 CDS YP_001850379.1 183982088 6226339 2499913..2500647 1 NC_010612.1 hypothetical protein 2500647 6226339 MMAR_2074 Mycobacterium marinum M hypothetical protein YP_001850379.1 2499913 D 216594 CDS YP_001850380.1 183982089 6226340 2500683..2501915 1 NC_010612.1 hypothetical protein 2501915 6226340 MMAR_2075 Mycobacterium marinum M hypothetical protein YP_001850380.1 2500683 D 216594 CDS YP_001850381.1 183982090 6226341 2501969..2502763 1 NC_010612.1 hypothetical protein 2502763 6226341 MMAR_2076 Mycobacterium marinum M hypothetical protein YP_001850381.1 2501969 D 216594 CDS YP_001850382.1 183982091 6226342 complement(2502760..2503653) 1 NC_010612.1 hypothetical protein 2503653 6226342 MMAR_2077 Mycobacterium marinum M hypothetical protein YP_001850382.1 2502760 R 216594 CDS YP_001850383.1 183982092 6226343 complement(2503783..2504607) 1 NC_010612.1 methylation of unknown substrate; methyltransferase 2504607 6226343 MMAR_2078 Mycobacterium marinum M methyltransferase YP_001850383.1 2503783 R 216594 CDS YP_001850384.1 183982093 6226344 complement(2504797..2506215) 1 NC_010612.1 involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; integral membrane nitrite extrusion protein NarK3 2506215 narK3 6226344 narK3 Mycobacterium marinum M integral membrane nitrite extrusion protein NarK3 YP_001850384.1 2504797 R 216594 CDS YP_001850385.1 183982094 6226345 2506383..2506730 1 NC_010612.1 involved in electron transfer; ferredoxin FdxA 2506730 fdxA_1 6226345 fdxA_1 Mycobacterium marinum M ferredoxin FdxA YP_001850385.1 2506383 D 216594 CDS YP_001850386.1 183982095 6226346 2506740..2507411 1 NC_010612.1 transcriptional regulator 2507411 6226346 MMAR_2081 Mycobacterium marinum M transcriptional regulator YP_001850386.1 2506740 D 216594 CDS YP_001850387.1 183982096 6226347 2507408..2507833 1 NC_010612.1 hypothetical protein 2507833 6226347 MMAR_2082 Mycobacterium marinum M hypothetical protein YP_001850387.1 2507408 D 216594 CDS YP_001850388.1 183982097 6226348 2507846..2508190 1 NC_010612.1 hypothetical protein 2508190 6226348 MMAR_2083 Mycobacterium marinum M hypothetical protein YP_001850388.1 2507846 D 216594 CDS YP_001850389.1 183982098 6226349 2508193..2509137 1 NC_010612.1 function unknown but contains pfam03060 domain, NPD, 2-nitropropane dioxygenase. members of this family catalyse the denitrification of a number of nitroalkanes using either fad or FMN as a cofactor; hypothetical protein 2509137 6226349 MMAR_2084 Mycobacterium marinum M hypothetical protein YP_001850389.1 2508193 D 216594 CDS YP_001850390.1 183982099 6226350 complement(2509170..2509673) 1 NC_010612.1 hypothetical protein 2509673 6226350 MMAR_2085 Mycobacterium marinum M hypothetical protein YP_001850390.1 2509170 R 216594 CDS YP_001850391.1 183982100 6226351 2509753..2510613 1 NC_010612.1 oxidoreductase 2510613 6226351 MMAR_2086 Mycobacterium marinum M oxidoreductase YP_001850391.1 2509753 D 216594 CDS YP_001850392.1 183982101 6226352 2510700..2511323 1 NC_010612.1 hypothetical protein 2511323 6226352 MMAR_2087 Mycobacterium marinum M hypothetical protein YP_001850392.1 2510700 D 216594 CDS YP_001850393.1 183982102 6226353 2511451..2513526 1 NC_010612.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 2513526 thrS 6226353 thrS Mycobacterium marinum M threonyl-tRNA synthetase YP_001850393.1 2511451 D 216594 CDS YP_001850394.1 183982103 6226354 2513529..2514101 1 NC_010612.1 function unknown, but location and domain identity to hydrlases suggests it could be involved in lipid metabolism; hypothetical protein 2514101 6226354 MMAR_2089 Mycobacterium marinum M hypothetical protein YP_001850394.1 2513529 D 216594 CDS YP_001850395.1 183982104 6226355 2514109..2514813 1 NC_010612.1 catalyzes the transfer of a free alcohol (inositol) onto CDP-diacylglycerol. the product of this putative ORF seems be essential to mycobacteria [catalytic activity: CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl 1D- myo-inositol]; pi synthase PgsA1 2514813 pgsA1 6226355 pgsA1 Mycobacterium marinum M pi synthase PgsA1 YP_001850395.1 2514109 D 216594 CDS YP_001850396.1 183982105 6226356 2514810..2515760 1 NC_010612.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 2515760 6226356 MMAR_2091 Mycobacterium marinum M lipid A biosynthesis lauroyl acyltransferase YP_001850396.1 2514810 D 216594 CDS YP_001850397.1 183982106 6226357 2515760..2516884 1 NC_010612.1 involved in the first mannosylation step in phosphatidylinositol mannoside biosynthesis (transfer of mannose residues onto pi, leading to the synthesis of phosphatidylinositol monomannoside); alpha-mannosyltransferase PimA 2516884 pimA 6226357 pimA Mycobacterium marinum M alpha-mannosyltransferase PimA YP_001850397.1 2515760 D 216594 CDS YP_001850398.1 183982107 6226358 2516884..2517951 1 NC_010612.1 function unknown but contains a NUDIX domain; hypothetical protein 2517951 6226358 MMAR_2093 Mycobacterium marinum M hypothetical protein YP_001850398.1 2516884 D 216594 CDS YP_001850399.1 183982108 6226359 2518143..2518991 1 NC_010612.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 2518991 snzP 6226359 snzP Mycobacterium marinum M pyridoxal biosynthesis lyase PdxS YP_001850399.1 2518143 D 216594 CDS YP_001850400.1 183982109 6226360 2519001..2519846 1 NC_010612.1 function unknown, lipolytic enzyme involved in cellular metabolism. can hydrolyze a broad range of acyl- CoA thioesters; acyl-CoA thioesterase II TesB2 2519846 tesB2 6226360 tesB2 Mycobacterium marinum M acyl-CoA thioesterase II TesB2 YP_001850400.1 2519001 D 216594 CDS YP_001850401.1 183982110 6226361 2519854..2520450 1 NC_010612.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 2520450 snoP 6226361 snoP Mycobacterium marinum M glutamine amidotransferase subunit PdxT YP_001850401.1 2519854 D 216594 CDS YP_001850402.1 183982111 6226362 complement(2520477..2522264) 1 NC_010612.1 function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages; PE-PGRS family protein 2522264 6226362 MMAR_2097 Mycobacterium marinum M PE-PGRS family protein YP_001850402.1 2520477 R 216594 CDS YP_001850403.1 183982112 6226363 2522539..2523294 1 NC_010612.1 highly conserved protein; hypothetical protein 2523294 6226363 MMAR_2098 Mycobacterium marinum M hypothetical protein YP_001850403.1 2522539 D 216594 CDS YP_001850404.1 183982113 6226364 complement(2523310..2524527) 1 NC_010612.1 transcriptional regulator 2524527 6226364 MMAR_2099 Mycobacterium marinum M transcriptional regulator YP_001850404.1 2523310 R 216594 CDS YP_001850405.1 183982114 6226365 2524988..2529181 1 NC_010612.1 PE-PGRS family protein 2529181 6226365 MMAR_2100 Mycobacterium marinum M PE-PGRS family protein YP_001850405.1 2524988 D 216594 CDS YP_001850406.1 183982115 6226366 2529363..2529860 1 NC_010612.1 hypothetical protein 2529860 6226366 MMAR_2101 Mycobacterium marinum M hypothetical protein YP_001850406.1 2529363 D 216594 CDS YP_001850407.1 183982116 6226367 2530065..2534225 1 NC_010612.1 PE-PGRS family protein 2534225 6226367 MMAR_2102 Mycobacterium marinum M PE-PGRS family protein YP_001850407.1 2530065 D 216594 CDS YP_001850408.1 183982117 6226368 2534389..2536353 1 NC_010612.1 PE-PGRS family protein 2536353 6226368 MMAR_2103 Mycobacterium marinum M PE-PGRS family protein YP_001850408.1 2534389 D 216594 CDS YP_001850409.1 183982118 6226369 complement(2536366..2537946) 1 NC_010612.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 2537946 speE 6226369 speE Mycobacterium marinum M spermidine synthase YP_001850409.1 2536366 R 216594 CDS YP_001850410.1 183982119 6226370 complement(2537943..2538413) 1 NC_010612.1 hypothetical protein 2538413 6226370 MMAR_2105 Mycobacterium marinum M hypothetical protein YP_001850410.1 2537943 R 216594 CDS YP_001850411.1 183982120 6226371 complement(2538447..2538878) 1 NC_010612.1 function unknown, possible membrane protein; hypothetical protein 2538878 6226371 MMAR_2106 Mycobacterium marinum M hypothetical protein YP_001850411.1 2538447 R 216594 CDS YP_001850412.1 183982121 6226372 complement(2538875..2539387) 1 NC_010612.1 hypothetical protein 2539387 6226372 MMAR_2107 Mycobacterium marinum M hypothetical protein YP_001850412.1 2538875 R 216594 CDS YP_001850413.1 183982122 6226373 complement(2539397..2540005) 1 NC_010612.1 hypothetical protein 2540005 6226373 MMAR_2108 Mycobacterium marinum M hypothetical protein YP_001850413.1 2539397 R 216594 CDS YP_001850414.1 183982123 6226374 2540220..2540774 1 NC_010612.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 2540774 ruvC 6226374 ruvC Mycobacterium marinum M Holliday junction resolvase YP_001850414.1 2540220 D 216594 CDS YP_001850415.1 183982124 6226375 2540771..2541364 1 NC_010612.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 2541364 ruvA 6226375 ruvA Mycobacterium marinum M Holliday junction DNA helicase RuvA YP_001850415.1 2540771 D 216594 CDS YP_001850416.1 183982125 6226376 2541368..2542405 1 NC_010612.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 2542405 ruvB 6226376 ruvB Mycobacterium marinum M Holliday junction DNA helicase RuvB YP_001850416.1 2541368 D 216594 CDS YP_001850417.1 183982126 6226377 complement(2542431..2544164) 1 NC_010612.1 PE-PGRS family protein 2544164 6226377 MMAR_2112 Mycobacterium marinum M PE-PGRS family protein YP_001850417.1 2542431 R 216594 CDS YP_001850418.1 183982127 6226378 complement(2544385..2546025) 1 NC_010612.1 PE-PGRS family protein 2546025 6226378 MMAR_2113 Mycobacterium marinum M PE-PGRS family protein YP_001850418.1 2544385 R 216594 CDS YP_001850419.1 183982128 6226379 2546220..2546606 1 NC_010612.1 function unknown, domain identity membrane protein Cdd COG3759; hypothetical protein 2546606 6226379 MMAR_2114 Mycobacterium marinum M hypothetical protein YP_001850419.1 2546220 D 216594 CDS YP_001850420.1 183982129 6226380 2546696..2547388 1 NC_010612.1 hypothetical protein 2547388 6226380 MMAR_2115 Mycobacterium marinum M hypothetical protein YP_001850420.1 2546696 D 216594 CDS YP_001850421.1 183982130 6226381 complement(2547426..2549558) 1 NC_010612.1 PE-PGRS family protein 2549558 6226381 MMAR_2116 Mycobacterium marinum M PE-PGRS family protein YP_001850421.1 2547426 R 216594 CDS YP_001850422.1 183982131 6226382 complement(2549712..2553236) 1 NC_010612.1 function unknown, but involved in lipid degradation; fatty-acid-CoA ligase FadD9 2553236 fadD9 6226382 fadD9 Mycobacterium marinum M fatty-acid-CoA ligase FadD9 YP_001850422.1 2549712 R 216594 CDS YP_001850423.1 183982132 6226383 complement(2553417..2554757) 1 NC_010612.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2554757 gabT 6226383 gabT Mycobacterium marinum M 4-aminobutyrate aminotransferase YP_001850423.1 2553417 R 216594 CDS YP_001850424.1 183982133 6226384 2554987..2555328 1 NC_010612.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 2555328 yajC 6226384 yajC Mycobacterium marinum M preprotein translocase subunit YajC YP_001850424.1 2554987 D 216594 CDS YP_001850425.1 183982134 6226385 2555440..2557287 1 NC_010612.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 2557287 secD 6226385 secD Mycobacterium marinum M preprotein translocase subunit SecD YP_001850425.1 2555440 D 216594 CDS YP_001850426.1 183982135 6226386 2557292..2558632 1 NC_010612.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 2558632 secF 6226386 secF Mycobacterium marinum M preprotein translocase subunit SecF YP_001850426.1 2557292 D 216594 CDS YP_001850427.1 183982136 6226387 2558638..2560350 1 NC_010612.1 function unknown. possible COG0747, DdpA, ABC-type dipeptide transport system, periplasmic component [amino acid transport and metabolism]; dipeptide ABC transporter periplasmic protein 2560350 6226387 MMAR_2122 Mycobacterium marinum M dipeptide ABC transporter periplasmic protein YP_001850427.1 2558638 D 216594 CDS YP_001850428.1 183982137 6226388 2560347..2560901 1 NC_010612.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 2560901 apt 6226388 apt Mycobacterium marinum M adenine phosphoribosyltransferase YP_001850428.1 2560347 D 216594 CDS YP_001850429.1 183982138 6226389 2560978..2563341 1 NC_010612.1 involved in the metabolism of PPGPP (at the first step). in eubacteria PPGPP (guanosine 3'-diphosphate 5- 'diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. this enzyme catalyzes the formation of PPPGPP which is then hydrolysed to form PPGPP [catalytic activity: ATP + GTP = AMP + guanosine 3'- diphosphate 5-'triphosphate]; GTP pyrophosphokinase RelA 2563341 relA 6226389 relA Mycobacterium marinum M GTP pyrophosphokinase RelA YP_001850429.1 2560978 D 216594 CDS YP_001850430.1 183982139 6226390 complement(2563398..2564285) 1 NC_010612.1 ppiases accelerate the folding of proteins [catalytic activity: cis-trans isomerization of proline imidic peptide bonds in oligopeptides]; peptidyl-prolyl cis-trans isomerase B PpiB 2564285 ppiB 6226390 ppiB Mycobacterium marinum M peptidyl-prolyl cis-trans isomerase B PpiB YP_001850430.1 2563398 R 216594 CDS YP_001850431.1 183982140 6226391 2564426..2565100 1 NC_010612.1 involved in glyoxal pathway. thioesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid [catalytic activity: (S)-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2- hydroxy acid anion]; Zn-dependent glyoxylase 2565100 6226391 MMAR_2126 Mycobacterium marinum M Zn-dependent glyoxylase YP_001850431.1 2564426 D 216594 CDS YP_001850432.1 183982141 6226392 2565097..2566359 1 NC_010612.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2566359 hisS 6226392 hisS Mycobacterium marinum M histidyl-tRNA synthetase YP_001850432.1 2565097 D 216594 CDS YP_001850433.1 183982142 6226393 2566424..2567518 1 NC_010612.1 In M. tuberculosis this CDS is REGULATED BY LexA; 13e12 repeat-containing protein 2567518 6226393 MMAR_2128 Mycobacterium marinum M 13e12 repeat-containing protein YP_001850433.1 2566424 D 216594 CDS YP_001850434.1 183982143 6226394 2567528..2568967 1 NC_010612.1 DNA integration - phage mediated; site-specific integrase 2568967 6226394 MMAR_2129 Mycobacterium marinum M site-specific integrase YP_001850434.1 2567528 D 216594 CDS YP_001850435.1 183982144 6226395 complement(2569173..2570786) 1 NC_010612.1 initiation of DNA replication for an episomal element; replication initiator protein 2570786 6226395 MMAR_2130 Mycobacterium marinum M replication initiator protein YP_001850435.1 2569173 R 216594 CDS YP_001850436.1 183982145 6226396 complement(2570783..2572183) 1 NC_010612.1 possible role in DNA segregation during cell division; DNA segregation ATPase FtsK/SpoIIIE-like protein 2572183 6226396 MMAR_2131 Mycobacterium marinum M DNA segregation ATPase FtsK/SpoIIIE-like protein YP_001850436.1 2570783 R 216594 CDS YP_001850437.1 183982146 6226397 complement(2572281..2572622) 1 NC_010612.1 function unknown, domain homology suggests role in initiation of plasmid replication; hypothetical protein 2572622 6226397 MMAR_2132 Mycobacterium marinum M hypothetical protein YP_001850437.1 2572281 R 216594 CDS YP_001850438.1 183982147 6226398 2572904..2573239 1 NC_010612.1 hypothetical protein 2573239 6226398 MMAR_2133 Mycobacterium marinum M hypothetical protein YP_001850438.1 2572904 D 216594 CDS YP_001850439.1 183982148 6226399 2573226..2574443 1 NC_010612.1 transcriptional regulatory protein 2574443 6226399 MMAR_2134 Mycobacterium marinum M transcriptional regulatory protein YP_001850439.1 2573226 D 216594 CDS YP_001850440.1 183982149 6226400 complement(2575073..2575786) 1 NC_010612.1 metal transport protein 2575786 6226400 MMAR_2136 Mycobacterium marinum M metal transport protein YP_001850440.1 2575073 R 216594 CDS YP_001850441.1 183982150 6226401 2576131..2577120 1 NC_010612.1 function unknown; possibly involved in transport of metal ions across the membrane; metal transport protein 2577120 6226401 MMAR_2137 Mycobacterium marinum M metal transport protein YP_001850441.1 2576131 D 216594 CDS YP_001850442.1 183982151 6226402 2577333..2577755 1 NC_010612.1 function unknown but contains a putative protein-S- isoprenylcysteine methyltransferase domain; membrane-associated methyltransferase 2577755 6226402 MMAR_2138 Mycobacterium marinum M membrane-associated methyltransferase YP_001850442.1 2577333 D 216594 CDS YP_001850443.1 183982152 6226403 2577880..2578320 1 NC_010612.1 involved in transcriptional mechanism. probably ArsR-family; transcriptional regulatory protein 2578320 6226403 MMAR_2139 Mycobacterium marinum M transcriptional regulatory protein YP_001850443.1 2577880 D 216594 CDS YP_001850444.1 183982153 6226404 2578390..2580729 1 NC_010612.1 metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)]; metal cation transporter p-type ATPase 2580729 6226404 MMAR_2140 Mycobacterium marinum M metal cation transporter p-type ATPase YP_001850444.1 2578390 D 216594 CDS YP_001850445.1 183982154 6226405 complement(2580790..2581569) 1 NC_010612.1 hypothetical protein 2581569 6226405 MMAR_2141 Mycobacterium marinum M hypothetical protein YP_001850445.1 2580790 R 216594 CDS YP_001850446.1 183982155 6226406 complement(2582027..2582317) 1 NC_010612.1 hypothetical protein 2582317 6226406 MMAR_2142 Mycobacterium marinum M hypothetical protein YP_001850446.1 2582027 R 216594 CDS YP_001850447.1 183982156 6226407 complement(2582330..2582581) 1 NC_010612.1 hypothetical protein 2582581 6226407 MMAR_2143 Mycobacterium marinum M hypothetical protein YP_001850447.1 2582330 R 216594 CDS YP_001850448.1 183982157 6226408 2582864..2583781 1 NC_010612.1 function unknown; possibly involved in transport of metal ions across the membrane; hypothetical protein 2583781 6226408 MMAR_2144 Mycobacterium marinum M hypothetical protein YP_001850448.1 2582864 D 216594 CDS YP_001850449.1 183982158 6226409 2584200..2585831 1 NC_010612.1 function unknown; contains a possible alkaline phosphatase domain; hypothetical protein 2585831 6226409 MMAR_2145 Mycobacterium marinum M hypothetical protein YP_001850449.1 2584200 D 216594 CDS YP_001850450.1 183982159 6226410 2586069..2586350 1 NC_010612.1 function unknown; hypothetical protein 2586350 6226410 MMAR_2146 Mycobacterium marinum M hypothetical protein YP_001850450.1 2586069 D 216594 CDS YP_001850451.1 183982160 6226411 2586359..2588509 1 NC_010612.1 metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation-transporting p-type ATPase C 2588509 6226411 MMAR_2147 Mycobacterium marinum M metal cation-transporting p-type ATPase C YP_001850451.1 2586359 D 216594 CDS YP_001850452.1 183982161 6226412 2589842..2590870 1 NC_010612.1 May be regulated by LexA; hypothetical protein 2590870 6226412 MMAR_2148 Mycobacterium marinum M hypothetical protein YP_001850452.1 2589842 D 216594 CDS YP_001850453.1 183982162 6226413 complement(2590878..2592461) 1 NC_010612.1 hypothetical protein 2592461 6226413 MMAR_2149 Mycobacterium marinum M hypothetical protein YP_001850453.1 2590878 R 216594 CDS YP_001850454.1 183982163 6226414 complement(2592500..2593345) 1 NC_010612.1 Contains patatin domain. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase.; patatin-like phospholipase catalysing the cleavage of fatty acids from membrane lipids; alpha-beta hydrolase superfamily esterase 2593345 6226414 MMAR_2150 Mycobacterium marinum M alpha-beta hydrolase superfamily esterase YP_001850454.1 2592500 R 216594 CDS YP_001850455.1 183982164 6226415 2593374..2593856 1 NC_010612.1 hypothetical protein 2593856 6226415 MMAR_2151 Mycobacterium marinum M hypothetical protein YP_001850455.1 2593374 D 216594 CDS YP_001850456.1 183982165 6226416 complement(2593868..2594410) 1 NC_010612.1 function unknown. contains Cdd pfam01381, HTH_3, helix-turn-helix of DNA binding proteins; transcriptional regulator 2594410 6226416 MMAR_2152 Mycobacterium marinum M transcriptional regulator YP_001850456.1 2593868 R 216594 CDS YP_001850457.1 183982166 6226417 2594503..2595288 1 NC_010612.1 contains partial (N-terminal) Cdd pfam00596, aldolase_II, class II aldolase and adducin N-terminal domain; class II aldolase/adducin domain-containing protein 2595288 6226417 MMAR_2153 Mycobacterium marinum M class II aldolase/adducin domain-containing protein YP_001850457.1 2594503 D 216594 CDS YP_001850458.1 183982167 6226418 2595326..2596216 1 NC_010612.1 involved in biosynthesis of diaminopimelate and lysine from aspartate semialdehyde (at the first step) [catalytic activity: l-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O]; dihydrodipicolinate synthase DapA 2596216 dapA_1 6226418 dapA_1 Mycobacterium marinum M dihydrodipicolinate synthase DapA YP_001850458.1 2595326 D 216594 CDS YP_001850459.1 183982168 6226419 complement(2596266..2597150) 1 NC_010612.1 membrane glycine rich protein 2597150 6226419 MMAR_2155 Mycobacterium marinum M membrane glycine rich protein YP_001850459.1 2596266 R 216594 CDS YP_001850460.1 183982169 6226420 complement(2597212..2597727) 1 NC_010612.1 hypothetical protein 2597727 6226420 MMAR_2156 Mycobacterium marinum M hypothetical protein YP_001850460.1 2597212 R 216594 CDS YP_001850461.1 183982170 6226421 complement(2597746..2598552) 1 NC_010612.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 2598552 apbA_1 6226421 apbA_1 Mycobacterium marinum M 2-dehydropantoate 2-reductase YP_001850461.1 2597746 R 216594 CDS YP_001850462.1 183982171 6226422 2598725..2600506 1 NC_010612.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2600506 aspS 6226422 aspS Mycobacterium marinum M aspartyl-tRNA synthetase YP_001850462.1 2598725 D 216594 CDS YP_001850463.1 183982172 6226423 2600503..2600937 1 NC_010612.1 function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins; hypothetical protein 2600937 6226423 MMAR_2159 Mycobacterium marinum M hypothetical protein YP_001850463.1 2600503 D 216594 CDS YP_001850464.1 183982173 6226424 2600957..2602015 1 NC_010612.1 transmembrane alanine and valine and leucine rich protein 2602015 6226424 MMAR_2160 Mycobacterium marinum M transmembrane alanine and valine and leucine rich protein YP_001850464.1 2600957 D 216594 CDS YP_001850465.1 183982174 6226425 complement(2602022..2602420) 1 NC_010612.1 hypothetical protein 2602420 6226425 MMAR_2161 Mycobacterium marinum M hypothetical protein YP_001850465.1 2602022 R 216594 CDS YP_001850466.1 183982175 6226426 2602488..2603498 1 NC_010612.1 function unknown, but contains Cdd COG1305, transglutaminase-like enzymes, putative cysteine proteases; hypothetical protein 2603498 6226426 MMAR_2162 Mycobacterium marinum M hypothetical protein YP_001850466.1 2602488 D 216594 CDS YP_001850467.1 183982176 6226427 2603491..2604546 1 NC_010612.1 hypothetical protein 2604546 6226427 MMAR_2163 Mycobacterium marinum M hypothetical protein YP_001850467.1 2603491 D 216594 CDS YP_001850468.1 183982177 6226428 complement(2604570..2607245) 1 NC_010612.1 hypothetical protein 2607245 6226428 MMAR_2164 Mycobacterium marinum M hypothetical protein YP_001850468.1 2604570 R 216594 CDS YP_001850469.1 183982178 6226429 complement(2607291..2610641) 1 NC_010612.1 function unknown; possible proteolytic activity (cysteine protease); transglutaminase family protein 2610641 6226429 MMAR_2165 Mycobacterium marinum M transglutaminase family protein YP_001850469.1 2607291 R 216594 CDS YP_001850470.1 183982179 6226430 complement(2610780..2611913) 1 NC_010612.1 proline and glycine rich transmembrane protein 2611913 6226430 MMAR_2166 Mycobacterium marinum M proline and glycine rich transmembrane protein YP_001850470.1 2610780 R 216594 CDS YP_001850471.1 183982180 6226431 2612104..2613462 1 NC_010612.1 recombination factor protein RarA 2613462 6226431 MMAR_2167 Mycobacterium marinum M recombination factor protein RarA YP_001850471.1 2612104 D 216594 CDS YP_001850472.1 183982181 6226432 complement(2613508..2614260) 1 NC_010612.1 function unknown, thought to be involved in the persistence in the host; hypothetical protein 2614260 6226432 MMAR_2168 Mycobacterium marinum M hypothetical protein YP_001850472.1 2613508 R 216594 CDS YP_001850473.1 183982182 6226433 2614344..2614745 1 NC_010612.1 hypothetical protein 2614745 6226433 MMAR_2169 Mycobacterium marinum M hypothetical protein YP_001850473.1 2614344 D 216594 CDS YP_001850474.1 183982183 6226434 2614864..2617569 1 NC_010612.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 2617569 alaS 6226434 alaS Mycobacterium marinum M alanyl-tRNA synthetase YP_001850474.1 2614864 D 216594 CDS YP_001850475.1 183982184 6226435 2617570..2618082 1 NC_010612.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 2618082 6226435 MMAR_2171 Mycobacterium marinum M Holliday junction resolvase-like protein YP_001850475.1 2617570 D 216594 CDS YP_001850476.1 183982185 6226436 2618075..2619331 1 NC_010612.1 hypothetical protein 2619331 6226436 MMAR_2172 Mycobacterium marinum M hypothetical protein YP_001850476.1 2618075 D 216594 CDS YP_001850477.1 183982186 6226437 2619328..2620161 1 NC_010612.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 2620161 aroE 6226437 aroE Mycobacterium marinum M shikimate 5-dehydrogenase YP_001850477.1 2619328 D 216594 CDS YP_001850478.1 183982187 6226438 2620173..2620616 1 NC_010612.1 hypothetical protein 2620616 6226438 MMAR_2174 Mycobacterium marinum M hypothetical protein YP_001850478.1 2620173 D 216594 CDS YP_001850479.1 183982188 6226439 2620693..2621916 1 NC_010612.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2621916 aroF 6226439 aroF Mycobacterium marinum M chorismate synthase YP_001850479.1 2620693 D 216594 CDS YP_001850480.1 183982189 6226440 2621925..2622479 1 NC_010612.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 2622479 aroK 6226440 aroK Mycobacterium marinum M shikimate kinase YP_001850480.1 2621925 D 216594 CDS YP_001850481.1 183982190 6226441 2622476..2623564 1 NC_010612.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 2623564 aroB 6226441 aroB Mycobacterium marinum M 3-dehydroquinate synthase YP_001850481.1 2622476 D 216594 CDS YP_001850482.1 183982191 6226442 2623561..2624001 1 NC_010612.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 2624001 aroD 6226442 aroD Mycobacterium marinum M 3-dehydroquinate dehydratase YP_001850482.1 2623561 D 216594 CDS YP_001850483.1 183982192 6226443 complement(2623998..2624756) 1 NC_010612.1 transmembrane protein 2624756 6226443 MMAR_2179 Mycobacterium marinum M transmembrane protein YP_001850483.1 2623998 R 216594 CDS YP_001850484.1 183982193 6226444 2624790..2625908 1 NC_010612.1 function unknown, hydrolyses peptides; cytoplasmic peptidase PepQ 2625908 pepQ 6226444 pepQ Mycobacterium marinum M cytoplasmic peptidase PepQ YP_001850484.1 2624790 D 216594 CDS YP_001850485.1 183982194 6226445 2625923..2626486 1 NC_010612.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 2626486 efp 6226445 efp Mycobacterium marinum M elongation factor P YP_001850485.1 2625923 D 216594 CDS YP_001850486.1 183982195 6226446 2626489..2627010 1 NC_010612.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 2627010 nusB 6226446 nusB Mycobacterium marinum M transcription antitermination protein NusB YP_001850486.1 2626489 D 216594 CDS YP_001850487.1 183982196 6226447 2627010..2627417 1 NC_010612.1 hypothetical protein 2627417 6226447 MMAR_2183 Mycobacterium marinum M hypothetical protein YP_001850487.1 2627010 D 216594 CDS YP_001850488.1 183982197 6226448 2627599..2630430 1 NC_010612.1 function unknown. could be an ornithine/arginine/lysine decarboxylase involved in the biosynthesis of spermidine from arginine; amino acid decarboxylase 2630430 6226448 MMAR_2184 Mycobacterium marinum M amino acid decarboxylase YP_001850488.1 2627599 D 216594 CDS YP_001850489.1 183982198 6226449 complement(2630436..2631656) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 2631656 6226449 MMAR_2185 Mycobacterium marinum M oxidoreductase YP_001850489.1 2630436 R 216594 CDS YP_001850490.1 183982199 6226450 complement(2631702..2632274) 1 NC_010612.1 hypothetical protein 2632274 6226450 MMAR_2186 Mycobacterium marinum M hypothetical protein YP_001850490.1 2631702 R 216594 CDS YP_001850491.1 183982200 6226451 complement(2632290..2633495) 1 NC_010612.1 function unknown; beta-lactamase 2633495 6226451 MMAR_2187 Mycobacterium marinum M beta-lactamase YP_001850491.1 2632290 R 216594 CDS YP_001850492.1 183982201 6226452 2633904..2634782 1 NC_010612.1 lipoprotein LprF 2634782 lprF 6226452 lprF Mycobacterium marinum M lipoprotein LprF YP_001850492.1 2633904 D 216594 CDS YP_001850493.1 183982202 6226453 2635049..2636512 1 NC_010612.1 hypothetical protein 2636512 6226453 MMAR_2189 Mycobacterium marinum M hypothetical protein YP_001850493.1 2635049 D 216594 CDS YP_001850494.1 183982203 6226454 2636509..2637690 1 NC_010612.1 chalcone/stilbene synthase 2637690 6226454 MMAR_2190 Mycobacterium marinum M chalcone/stilbene synthase YP_001850494.1 2636509 D 216594 CDS YP_001850495.1 183982204 6226455 2637690..2638784 1 NC_010612.1 involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids; glycolipid sulfotransferase 2638784 6226455 MMAR_2191 Mycobacterium marinum M glycolipid sulfotransferase YP_001850495.1 2637690 D 216594 CDS YP_001850496.1 183982205 6226456 2638784..2639797 1 NC_010612.1 involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids; glycolipid sulfotransferase 2639797 6226456 MMAR_2192 Mycobacterium marinum M glycolipid sulfotransferase YP_001850496.1 2638784 D 216594 CDS YP_001850497.1 183982206 6226457 complement(2639804..2640439) 1 NC_010612.1 NodS-like (sam)-dependent methyltransferase 2640439 6226457 MMAR_2193 Mycobacterium marinum M NodS-like (sam)-dependent methyltransferase YP_001850497.1 2639804 R 216594 CDS YP_001850498.1 183982207 6226458 2640623..2641186 1 NC_010612.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 2641186 pyrR 6226458 pyrR Mycobacterium marinum M bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase YP_001850498.1 2640623 D 216594 CDS YP_001850499.1 183982208 6226459 2641183..2642145 1 NC_010612.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 2642145 pyrB 6226459 pyrB Mycobacterium marinum M aspartate carbamoyltransferase catalytic subunit YP_001850499.1 2641183 D 216594 CDS YP_001850500.1 183982209 6226460 2642142..2643434 1 NC_010612.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 2643434 pyrC 6226460 pyrC Mycobacterium marinum M dihydroorotase YP_001850500.1 2642142 D 216594 CDS YP_001850501.1 183982210 6226461 2643431..2643952 1 NC_010612.1 secreted protein 2643952 6226461 MMAR_2197 Mycobacterium marinum M secreted protein YP_001850501.1 2643431 D 216594 CDS YP_001850502.1 183982211 6226462 2643949..2645076 1 NC_010612.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 2645076 carA 6226462 carA Mycobacterium marinum M carbamoyl phosphate synthase small subunit YP_001850502.1 2643949 D 216594 CDS YP_001850503.1 183982212 6226463 2645096..2648533 1 NC_010612.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 2648533 carB 6226463 carB Mycobacterium marinum M carbamoyl phosphate synthase large subunit YP_001850503.1 2645096 D 216594 CDS YP_001850504.1 183982213 6226464 2648530..2649366 1 NC_010612.1 type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 2649366 pyrF 6226464 pyrF Mycobacterium marinum M orotidine 5'-phosphate decarboxylase YP_001850504.1 2648530 D 216594 CDS YP_001850505.1 183982214 6226465 2650323..2650658 1 NC_010612.1 integration host factor MihF 2650658 mihF 6226465 mihF Mycobacterium marinum M integration host factor MihF YP_001850505.1 2650323 D 216594 CDS YP_001850506.1 183982215 6226466 2650788..2651381 1 NC_010612.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 2651381 gmk 6226466 gmk Mycobacterium marinum M guanylate kinase YP_001850506.1 2650788 D 216594 CDS YP_001850507.1 183982216 6226467 2651468..2651800 1 NC_010612.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 2651800 rpoZ 6226467 rpoZ Mycobacterium marinum M DNA-directed RNA polymerase subunit omega YP_001850507.1 2651468 D 216594 CDS YP_001850508.1 183982217 6226468 2651816..2653057 1 NC_010612.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 2653057 dfp 6226468 dfp Mycobacterium marinum M bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_001850508.1 2651816 D 216594 CDS YP_001850509.1 183982218 6226469 2653186..2654397 1 NC_010612.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 2654397 metK 6226469 metK Mycobacterium marinum M S-adenosylmethionine synthetase YP_001850509.1 2653186 D 216594 CDS YP_001850510.1 183982219 6226470 complement(2654479..2655054) 1 NC_010612.1 hypothetical protein 2655054 6226470 MMAR_2206 Mycobacterium marinum M hypothetical protein YP_001850510.1 2654479 R 216594 CDS YP_001850511.1 183982220 6226471 complement(2655146..2656630) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; monoxygenase 2656630 6226471 MMAR_2207 Mycobacterium marinum M monoxygenase YP_001850511.1 2655146 R 216594 CDS YP_001850512.1 183982221 6226472 complement(2656775..2657746) 1 NC_010612.1 lipase LipH 2657746 lipH 6226472 lipH Mycobacterium marinum M lipase LipH YP_001850512.1 2656775 R 216594 CDS YP_001850513.1 183982222 6226473 complement(2657773..2658747) 1 NC_010612.1 lipase LipI 2658747 lipI 6226473 lipI Mycobacterium marinum M lipase LipI YP_001850513.1 2657773 R 216594 CDS YP_001850514.1 183982223 6226474 2658773..2659483 1 NC_010612.1 membrane protein 2659483 6226474 MMAR_2210 Mycobacterium marinum M membrane protein YP_001850514.1 2658773 D 216594 CDS YP_001850515.1 183982224 6226475 2659594..2661540 1 NC_010612.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 2661540 priA 6226475 priA Mycobacterium marinum M primosome assembly protein PriA YP_001850515.1 2659594 D 216594 CDS YP_001850516.1 183982225 6226476 complement(2661558..2662382) 1 NC_010612.1 causes methylation; methyltransferase 2662382 6226476 MMAR_2212 Mycobacterium marinum M methyltransferase YP_001850516.1 2661558 R 216594 CDS YP_001850517.1 183982226 6226477 2662606..2663088 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 2663088 6226477 MMAR_2213 Mycobacterium marinum M transcriptional regulatory protein YP_001850517.1 2662606 D 216594 CDS YP_001850518.1 183982227 6226478 complement(2663212..2664036) 1 NC_010612.1 causes methylation; methyltransferase 2664036 6226478 MMAR_2214 Mycobacterium marinum M methyltransferase YP_001850518.1 2663212 R 216594 CDS YP_001850519.1 183982228 6226479 2664238..2665176 1 NC_010612.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 2665176 fmt 6226479 fmt Mycobacterium marinum M methionyl-tRNA formyltransferase YP_001850519.1 2664238 D 216594 CDS YP_001850520.1 183982229 6226480 2665173..2666618 1 NC_010612.1 Fmu protein 2666618 fmu 6226480 fmu Mycobacterium marinum M Fmu protein YP_001850520.1 2665173 D 216594 CDS YP_001850521.1 183982230 6226481 2666685..2667374 1 NC_010612.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 2667374 rpe 6226481 rpe Mycobacterium marinum M ribulose-phosphate 3-epimerase YP_001850521.1 2666685 D 216594 CDS YP_001850522.1 183982231 6226482 2667382..2668401 1 NC_010612.1 involved in riboflavin biosynthesis (at the second and third steps). converts 2,5-diamino-6-(ribosylamino)- 4(3H)-pyrimidinone 5'-phosphate into 5-amino-6- (ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate [catalytic activity 1: 2,5-diamino-6-hydroxy-4-(5- phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5- phosphoribosylamino)uracil + NH(3)] [catalytic activity 2: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5- amino-6-(5-phosphoribosylamino)uracil + NADPH]; bifunctional riboflavin biosynthesis protein RibG 2668401 ribG 6226482 ribG Mycobacterium marinum M bifunctional riboflavin biosynthesis protein RibG YP_001850522.1 2667382 D 216594 CDS YP_001850523.1 183982232 6226483 complement(2668406..2669959) 1 NC_010612.1 involved in transport of aminoglycosides and tetracycline across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane; aminoglycosides/tetracycline-transport integral membrane protein 2669959 6226483 MMAR_2219 Mycobacterium marinum M aminoglycosides/tetracycline-transport integral membrane protein YP_001850523.1 2668406 R 216594 CDS YP_001850524.1 183982233 6226484 complement(2669959..2670660) 1 NC_010612.1 lipoprotein LprG 2670660 lprG 6226484 lprG Mycobacterium marinum M lipoprotein LprG YP_001850524.1 2669959 R 216594 CDS YP_001850525.1 183982234 6226485 2670770..2671393 1 NC_010612.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 2671393 ribC 6226485 ribC Mycobacterium marinum M riboflavin synthase subunit alpha YP_001850525.1 2670770 D 216594 CDS YP_001850526.1 183982235 6226486 2671532..2672809 1 NC_010612.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein 2672809 ribA2 6226486 ribA2 Mycobacterium marinum M bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein YP_001850526.1 2671532 D 216594 CDS YP_001850527.1 183982236 6226487 2672806..2673288 1 NC_010612.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 2673288 ribH 6226487 ribH Mycobacterium marinum M 6,7-dimethyl-8-ribityllumazine synthase YP_001850527.1 2672806 D 216594 CDS YP_001850528.1 183982237 6226488 2673285..2673755 1 NC_010612.1 hypothetical protein 2673755 6226488 MMAR_2224 Mycobacterium marinum M hypothetical protein YP_001850528.1 2673285 D 216594 CDS YP_001850529.1 183982238 6226489 2673775..2674428 1 NC_010612.1 lipoprotein LprH 2674428 lprH 6226489 lprH Mycobacterium marinum M lipoprotein LprH YP_001850529.1 2673775 D 216594 CDS YP_001850530.1 183982239 6226490 2674474..2675943 1 NC_010612.1 In M. tuberculosis this CDS is REGULATED BY LexA; 13e12 repeat-containing protein 2675943 6226490 MMAR_2226 Mycobacterium marinum M 13e12 repeat-containing protein YP_001850530.1 2674474 D 216594 CDS YP_001850531.1 183982240 6226491 2675963..2677906 1 NC_010612.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 2677906 uvrC 6226491 uvrC Mycobacterium marinum M excinuclease ABC subunit C YP_001850531.1 2675963 D 216594 CDS YP_001850532.1 183982241 6226492 2677903..2678823 1 NC_010612.1 hypothetical protein 2678823 6226492 MMAR_2228 Mycobacterium marinum M hypothetical protein YP_001850532.1 2677903 D 216594 CDS YP_001850533.1 183982242 6226493 2678820..2679896 1 NC_010612.1 hypothetical protein 2679896 6226493 MMAR_2229 Mycobacterium marinum M hypothetical protein YP_001850533.1 2678820 D 216594 CDS YP_001850534.1 183982243 6226494 2679893..2680870 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein WhiA 2680870 whiA 6226494 whiA Mycobacterium marinum M transcriptional regulatory protein WhiA YP_001850534.1 2679893 D 216594 CDS YP_001850535.1 183982244 6226495 2680973..2682355 1 NC_010612.1 hypothetical protein 2682355 6226495 MMAR_2231 Mycobacterium marinum M hypothetical protein YP_001850535.1 2680973 D 216594 CDS YP_001850536.1 183982245 6226496 complement(2682356..2683639) 1 NC_010612.1 function unknown, but supposed involved in lipid metabolism; esterase LipO 2683639 lipO 6226496 lipO Mycobacterium marinum M esterase LipO YP_001850536.1 2682356 R 216594 CDS YP_001850537.1 183982246 6226497 complement(2683636..2685270) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2685270 fadD12 6226497 fadD12 Mycobacterium marinum M acyl-CoA synthetase YP_001850537.1 2683636 R 216594 CDS YP_001850538.1 183982247 6226498 complement(2685274..2686077) 1 NC_010612.1 hypothetical protein 2686077 6226498 MMAR_2234 Mycobacterium marinum M hypothetical protein YP_001850538.1 2685274 R 216594 CDS YP_001850539.1 183982248 6226499 2686288..2688126 1 NC_010612.1 PE-PGRS family protein 2688126 6226499 MMAR_2235 Mycobacterium marinum M PE-PGRS family protein YP_001850539.1 2686288 D 216594 CDS YP_001850540.1 183982249 6226500 2688330..2690078 1 NC_010612.1 hypothetical protein 2690078 6226500 MMAR_2236 Mycobacterium marinum M hypothetical protein YP_001850540.1 2688330 D 216594 CDS YP_001850541.1 183982250 6226501 2690075..2691496 1 NC_010612.1 function unknown, probably involved in cellular metabolism; dehydrogenase 2691496 6226501 MMAR_2237 Mycobacterium marinum M dehydrogenase YP_001850541.1 2690075 D 216594 CDS YP_001850542.1 183982251 6226502 complement(2691504..2692313) 1 NC_010612.1 hypothetical protein 2692313 6226502 MMAR_2238 Mycobacterium marinum M hypothetical protein YP_001850542.1 2691504 R 216594 CDS YP_001850543.1 183982252 6226503 2692597..2693616 1 NC_010612.1 involved in second phase of glycolysis (first step) [catalytic activity: D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.]; glyceraldehyde 3-phosphate dehydrogenase Gap 2693616 gap 6226503 gap Mycobacterium marinum M glyceraldehyde 3-phosphate dehydrogenase Gap YP_001850543.1 2692597 D 216594 CDS YP_001850544.1 183982253 6226504 2693629..2694879 1 NC_010612.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 2694879 pgk 6226504 pgk Mycobacterium marinum M phosphoglycerate kinase YP_001850544.1 2693629 D 216594 CDS YP_001850545.1 183982254 6226505 2694876..2695661 1 NC_010612.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 2695661 tpiA 6226505 tpiA Mycobacterium marinum M triosephosphate isomerase YP_001850545.1 2694876 D 216594 CDS YP_001850546.1 183982255 6226506 complement(2695706..2698645) 1 NC_010612.1 involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: 4-aminobutanoate + 2- oxoglutarate = succinate semialdehyde + L-glutamate]; hypothetical protein 2698645 gabT_1 6226506 gabT_1 Mycobacterium marinum M hypothetical protein YP_001850546.1 2695706 R 216594 CDS YP_001850547.1 183982256 6226507 complement(2698642..2700030) 1 NC_010612.1 thought to be involved in cationic amino acid transport across the membrane. responsible for the translocation of the substrate across the membrane; cationic amino acid transport integral membrane protein 2700030 6226507 MMAR_2243 Mycobacterium marinum M cationic amino acid transport integral membrane protein YP_001850547.1 2698642 R 216594 CDS YP_001850548.1 183982257 6226508 2700262..2700990 1 NC_010612.1 possibly involved in transcriptional mechanism; GntR family transcriptional regulator 2700990 6226508 MMAR_2244 Mycobacterium marinum M GntR family transcriptional regulator YP_001850548.1 2700262 D 216594 CDS YP_001850549.1 183982258 6226509 complement(2701024..2701512) 1 NC_010612.1 hypothetical protein 2701512 6226509 MMAR_2245 Mycobacterium marinum M hypothetical protein YP_001850549.1 2701024 R 216594 CDS YP_001850550.1 183982259 6226510 complement(2701527..2701760) 1 NC_010612.1 involved in protein export. participates in a early event of protein translocation; preprotein translocase subunit SecG 2701760 secG 6226510 secG Mycobacterium marinum M preprotein translocase subunit SecG YP_001850550.1 2701527 R 216594 CDS YP_001850551.1 183982260 6226511 2701830..2704637 1 NC_010612.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 2704637 ppc 6226511 ppc Mycobacterium marinum M phosphoenolpyruvate carboxylase YP_001850551.1 2701830 D 216594 CDS YP_001850552.1 183982261 6226512 complement(2704661..2705977) 1 NC_010612.1 PE-PGRS family protein 2705977 6226512 MMAR_2248 Mycobacterium marinum M PE-PGRS family protein YP_001850552.1 2704661 R 216594 CDS YP_001850553.1 183982262 6226513 complement(2706073..2706471) 1 NC_010612.1 hypothetical protein 2706471 6226513 MMAR_2249 Mycobacterium marinum M hypothetical protein YP_001850553.1 2706073 R 216594 CDS YP_001850554.1 183982263 6226514 complement(2706521..2707264) 1 NC_010612.1 involved in pentose phosphate pathway. hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. [catalytic activity : 6-phospho-D-glucono-1,5-lactone + H(2)O = 6- phospho-D-gluconate]; 6-phosphogluconolactonase 2707264 devB 6226514 devB Mycobacterium marinum M 6-phosphogluconolactonase YP_001850554.1 2706521 R 216594 CDS YP_001850555.1 183982264 6226515 complement(2707261..2708172) 1 NC_010612.1 may be involved in the functional assembly of glucose 6-phosphate dehydrogenase; OXPP cycle protein OpcA 2708172 opcA 6226515 opcA Mycobacterium marinum M OXPP cycle protein OpcA YP_001850555.1 2707261 R 216594 CDS YP_001850556.1 183982265 6226516 complement(2708275..2709828) 1 NC_010612.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 2709828 zwf2 6226516 zwf2 Mycobacterium marinum M glucose-6-phosphate 1-dehydrogenase YP_001850556.1 2708275 R 216594 CDS YP_001850557.1 183982266 6226517 complement(2709825..2710946) 1 NC_010612.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase 2710946 tal 6226517 tal Mycobacterium marinum M transaldolase YP_001850557.1 2709825 R 216594 CDS YP_001850558.1 183982267 6226518 complement(2710962..2713064) 1 NC_010612.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2713064 tkt 6226518 tkt Mycobacterium marinum M transketolase YP_001850558.1 2710962 R 216594 CDS YP_001850559.1 183982268 6226519 2713352..2714326 1 NC_010612.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 2714326 ctaB 6226519 ctaB Mycobacterium marinum M protoheme IX farnesyltransferase YP_001850559.1 2713352 D 216594 CDS YP_001850560.1 183982269 6226520 complement(2714406..2715773) 1 NC_010612.1 involved in HemE and porphyrin biosynthesis (at the penultimate step). catalyzes the 6-electron oxidation of protoporphyrinogen ix to form protoporphyrin ix [catalytic activity: protoporphyrinogen-IX + O(2) = protoporphyrin-IX + H(2)O(2)]; protoporphyrinogen oxidase, HemY 2715773 hemY_1 6226520 hemY_1 Mycobacterium marinum M protoporphyrinogen oxidase, HemY YP_001850560.1 2714406 R 216594 CDS YP_001850561.1 183982270 6226521 2716209..2719865 1 NC_010612.1 involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway). seems to have additional alpha-glucosidase activity; trehalose-6-phosphate phosphatase OtsB1 2719865 otsB1 6226521 otsB1 Mycobacterium marinum M trehalose-6-phosphate phosphatase OtsB1 YP_001850561.1 2716209 D 216594 CDS YP_001850562.1 183982271 6226522 2719993..2721276 1 NC_010612.1 involved in transcriptional mechanism; transcriptional activator protein 2721276 6226522 MMAR_2258 Mycobacterium marinum M transcriptional activator protein YP_001850562.1 2719993 D 216594 CDS YP_001850563.1 183982272 6226523 complement(2721330..2722340) 1 NC_010612.1 catalyzes the one electron reduction of certain quinones [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone reductase Qor 2722340 qor 6226523 qor Mycobacterium marinum M quinone reductase Qor YP_001850563.1 2721330 R 216594 CDS YP_001850564.1 183982273 6226524 2722339..2723193 1 NC_010612.1 hypothetical protein 2723193 6226524 MMAR_2260 Mycobacterium marinum M hypothetical protein YP_001850564.1 2722339 D 216594 CDS YP_001850565.1 183982274 6226525 complement(2723143..2724099) 1 NC_010612.1 thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; antibiotic ABC transporter transmembrane protein 2724099 6226525 MMAR_2261 Mycobacterium marinum M antibiotic ABC transporter transmembrane protein YP_001850565.1 2723143 R 216594 CDS YP_001850566.1 183982275 6226526 complement(2724143..2724931) 1 NC_010612.1 thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; antibiotic ABC transporter transmembrane protein 2724931 6226526 MMAR_2262 Mycobacterium marinum M antibiotic ABC transporter transmembrane protein YP_001850566.1 2724143 R 216594 CDS YP_001850567.1 183982276 6226527 complement(2724928..2725887) 1 NC_010612.1 thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for energy coupling to the transport system; antibiotic ABC transporter ATP-binding protein 2725887 6226527 MMAR_2263 Mycobacterium marinum M antibiotic ABC transporter ATP-binding protein YP_001850567.1 2724928 R 216594 CDS YP_001850568.1 183982277 6226528 complement(2725884..2727701) 1 NC_010612.1 integral membrane protein 2727701 6226528 MMAR_2264 Mycobacterium marinum M integral membrane protein YP_001850568.1 2725884 R 216594 CDS YP_001850569.1 183982278 6226529 2727782..2728567 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 2728567 6226529 MMAR_2265 Mycobacterium marinum M transcriptional regulatory protein YP_001850569.1 2727782 D 216594 CDS YP_001850570.1 183982279 6226530 2728564..2730009 1 NC_010612.1 hypothetical protein 2730009 6226530 MMAR_2266 Mycobacterium marinum M hypothetical protein YP_001850570.1 2728564 D 216594 CDS YP_001850571.1 183982280 6226531 2730006..2731205 1 NC_010612.1 hypothetical protein 2731205 6226531 MMAR_2267 Mycobacterium marinum M hypothetical protein YP_001850571.1 2730006 D 216594 CDS YP_001850572.1 183982281 6226532 2731202..2731984 1 NC_010612.1 thought to be involved in active transport across the membrane. responsible for energy coupling to the transport system; ABC transporter ATP-binding protein 2731984 6226532 MMAR_2268 Mycobacterium marinum M ABC transporter ATP-binding protein YP_001850572.1 2731202 D 216594 CDS YP_001850573.1 183982282 6226533 2731987..2733240 1 NC_010612.1 catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, l- selenocysteine, and L-selenocystine to produce L-alanine; cysteine desulfurase 2733240 csd 6226533 csd Mycobacterium marinum M cysteine desulfurase YP_001850573.1 2731987 D 216594 CDS YP_001850574.1 183982283 6226534 2733243..2733734 1 NC_010612.1 function unknown, probably involved in cellular metabolism; nitrogen fixation-like protein 2733734 6226534 MMAR_2270 Mycobacterium marinum M nitrogen fixation-like protein YP_001850574.1 2733243 D 216594 CDS YP_001850575.1 183982284 6226535 2733727..2734074 1 NC_010612.1 hypothetical protein 2734074 6226535 MMAR_2271 Mycobacterium marinum M hypothetical protein YP_001850575.1 2733727 D 216594 CDS YP_001850576.1 183982285 6226536 2734258..2735727 1 NC_010612.1 PE-PGRS family protein 2735727 6226536 MMAR_2272 Mycobacterium marinum M PE-PGRS family protein YP_001850576.1 2734258 D 216594 CDS YP_001850577.1 183982286 6226537 complement(2735739..2737568) 1 NC_010612.1 function unknown, but involvement in lipid degradation; acyl-CoA dehydrogenase FadE15 2737568 fadE15 6226537 fadE15 Mycobacterium marinum M acyl-CoA dehydrogenase FadE15 YP_001850577.1 2735739 R 216594 CDS YP_001850578.1 183982287 6226538 complement(2737674..2738771) 1 NC_010612.1 PE-PGRS family protein 2738771 6226538 MMAR_2274 Mycobacterium marinum M PE-PGRS family protein YP_001850578.1 2737674 R 216594 CDS YP_001850579.1 183982288 6226539 2739119..2741098 1 NC_010612.1 cation-transporting ATPase; possibly catalyzes the transport of a cation (possibly cadmium) with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + cation(in) = ADP + phosphate + cation(out)]; cation transporter p-type ATPase D CtpD 2741098 ctpD 6226539 ctpD Mycobacterium marinum M cation transporter p-type ATPase D CtpD YP_001850579.1 2739119 D 216594 CDS YP_001850580.1 183982289 6226540 2741193..2741549 1 NC_010612.1 thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions; thioredoxin TrxA 2741549 trxA 6226540 trxA Mycobacterium marinum M thioredoxin TrxA YP_001850580.1 2741193 D 216594 CDS YP_001850581.1 183982290 6226541 2741606..2741944 1 NC_010612.1 thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions; thioredoxin TrxB1 2741944 trxB1 6226541 trxB1 Mycobacterium marinum M thioredoxin TrxB1 YP_001850581.1 2741606 D 216594 CDS YP_001850582.1 183982291 6226542 2742028..2742837 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2742837 echA12 6226542 echA12 Mycobacterium marinum M enoyl-CoA hydratase YP_001850582.1 2742028 D 216594 CDS YP_001850583.1 183982292 6226543 2742862..2744490 1 NC_010612.1 probable macrolide-transport ATP-binding protein ABC transporter. thought to be involved in active transport of macrolide across the membrane; ABC transporter ATP-binding protein 2744490 6226543 MMAR_2279 Mycobacterium marinum M ABC transporter ATP-binding protein YP_001850583.1 2742862 D 216594 CDS YP_001850584.1 183982293 6226544 2744575..2744766 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 2744766 6226544 MMAR_2280 Mycobacterium marinum M transcriptional regulatory protein YP_001850584.1 2744575 D 216594 CDS YP_001850585.1 183982294 6226545 complement(2744768..2745331) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 2745331 6226545 MMAR_2281 Mycobacterium marinum M transcriptional regulatory protein YP_001850585.1 2744768 R 216594 CDS YP_001850586.1 183982295 6226546 complement(2745341..2748142) 1 NC_010612.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 2748142 acn 6226546 acn Mycobacterium marinum M aconitate hydratase YP_001850586.1 2745341 R 216594 CDS YP_001850587.1 183982296 6226547 2748463..2749014 1 NC_010612.1 hypothetical protein 2749014 6226547 MMAR_2283 Mycobacterium marinum M hypothetical protein YP_001850587.1 2748463 D 216594 CDS YP_001850588.1 183982297 6226548 2749246..2750655 1 NC_010612.1 similar to a hypothetical invasion protein. possibly an exported protein with unusually long signal sequence. NLP/P60 family protein; invasion and intracellular persistence protein, IipA 2750655 iipA 6226548 iipA Mycobacterium marinum M invasion and intracellular persistence protein, IipA YP_001850588.1 2749246 D 216594 CDS YP_001850589.1 183982298 6226549 2750660..2751400 1 NC_010612.1 homology to cell wall-associated hydrolases. possibly an exported protein of the NLP/P60 family; invasion and intracellular persistence protein, IipB 2751400 iipB 6226549 iipB Mycobacterium marinum M invasion and intracellular persistence protein, IipB YP_001850589.1 2750660 D 216594 CDS YP_001850590.1 183982299 6226550 2751599..2752714 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein, MoxR1 2752714 moxR1 6226550 moxR1 Mycobacterium marinum M transcriptional regulatory protein, MoxR1 YP_001850590.1 2751599 D 216594 CDS YP_001850591.1 183982300 6226551 2752729..2753685 1 NC_010612.1 hypothetical protein 2753685 6226551 MMAR_2287 Mycobacterium marinum M hypothetical protein YP_001850591.1 2752729 D 216594 CDS YP_001850592.1 183982301 6226552 2753720..2754727 1 NC_010612.1 hypothetical protein 2754727 6226552 MMAR_2288 Mycobacterium marinum M hypothetical protein YP_001850592.1 2753720 D 216594 CDS YP_001850593.1 183982302 6226553 2754841..2755608 1 NC_010612.1 involved in the fatty acid biosynthesis pathway (first reduction step) (mycolic acid biosynthesis); reduces KasA/KasB products [catalytic activity: (3R)-3- hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl- [acyl-carrier protein] + NADPH]; 3-oxoacyl-ACP reductase 2755608 fabG1 6226553 fabG1 Mycobacterium marinum M 3-oxoacyl-ACP reductase YP_001850593.1 2754841 D 216594 CDS YP_001850594.1 183982303 6226554 2755688..2756497 1 NC_010612.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 2756497 inhA 6226554 inhA Mycobacterium marinum M enoyl-(acyl carrier protein) reductase YP_001850594.1 2755688 D 216594 CDS YP_001850595.1 183982304 6226555 2756504..2757526 1 NC_010612.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 2757526 hemH 6226555 hemH Mycobacterium marinum M ferrochelatase YP_001850595.1 2756504 D 216594 CDS YP_001850596.1 183982305 6226556 complement(2757533..2758525) 1 NC_010612.1 hypothetical protein 2758525 6226556 MMAR_2292 Mycobacterium marinum M hypothetical protein YP_001850596.1 2757533 R 216594 CDS YP_001850597.1 183982306 6226557 2758541..2758975 1 NC_010612.1 function unknown. contains Cdd match to COG1585, COG1585, membrane protein implicated in regulation of membrane protease activity [posttranslational modification, protein turnover, chaperones / intracellular trafficking and secretion]; hypothetical protein 2758975 6226557 MMAR_2293 Mycobacterium marinum M hypothetical protein YP_001850597.1 2758541 D 216594 CDS YP_001850598.1 183982307 6226558 2758997..2760151 1 NC_010612.1 hypothetical protein 2760151 6226558 MMAR_2294 Mycobacterium marinum M hypothetical protein YP_001850598.1 2758997 D 216594 CDS YP_001850599.1 183982308 6226559 2760148..2760504 1 NC_010612.1 hypothetical protein 2760504 6226559 MMAR_2295 Mycobacterium marinum M hypothetical protein YP_001850599.1 2760148 D 216594 CDS YP_001850600.1 183982309 6226560 complement(2760501..2760968) 1 NC_010612.1 hypothetical protein 2760968 6226560 MMAR_2296 Mycobacterium marinum M hypothetical protein YP_001850600.1 2760501 R 216594 CDS YP_001850601.1 183982310 6226561 complement(2761001..2761615) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulator 2761615 6226561 MMAR_2297 Mycobacterium marinum M transcriptional regulator YP_001850601.1 2761001 R 216594 CDS YP_001850602.1 183982311 6226562 2762490..2763233 1 NC_010612.1 contains N-terminal Cdd pfam00072, response_reg, response regulator receiver domain. this domain receives the signal from the sensor partner in bacterial two- component systems. it is usually found N-terminal to a DNA binding effector domain. C-terminal conatins Cdd pfam00486, trans_reg_C, transcriptional regulatory protein, C terminal; two-component regulator receiver domain-containing protein 2763233 6226562 MMAR_2298 Mycobacterium marinum M two-component regulator receiver domain-containing protein YP_001850602.1 2762490 D 216594 CDS YP_001850603.1 183982312 6226563 2763233..2764753 1 NC_010612.1 two-component system response sensor kinase contains Cdd pfam02518, hATPase_C, histidine kinase-, DNA gyrase B-, and Hsp90-like ATPase; Cdd pfam00512, HisKA, his kinase a (phosphoacceptor) domain. dimerisation and phosphoacceptor domain of histidine kinases; two-component regulator - sensor kinase 2764753 6226563 MMAR_2299 Mycobacterium marinum M two-component regulator - sensor kinase YP_001850603.1 2763233 D 216594 CDS YP_001850604.1 183982313 6226564 complement(2764758..2765732) 1 NC_010612.1 hypothetical protein 2765732 6226564 MMAR_2300 Mycobacterium marinum M hypothetical protein YP_001850604.1 2764758 R 216594 CDS YP_001850605.1 183982314 6226565 complement(2765797..2766570) 1 NC_010612.1 conserved membrane protein of unknown function. similar to proteins from many organisms containing Cdd COG0398; uncharacterized conserved protein [function unknown]; hypothetical protein 2766570 6226565 MMAR_2301 Mycobacterium marinum M hypothetical protein YP_001850605.1 2765797 R 216594 CDS YP_001850606.1 183982315 6226566 2766763..2768640 1 NC_010612.1 involved in propionic acid fermentation. catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid- cycle intermediates [catalytic activity: (R)-2-methyl-3- oxopropanoyl-CoA = succinyl- CoA]; methylmalonyl-CoA mutase small subunit, MutA 2768640 mutA 6226566 mutA Mycobacterium marinum M methylmalonyl-CoA mutase small subunit, MutA YP_001850606.1 2766763 D 216594 CDS YP_001850607.1 183982316 6226567 2768646..2770907 1 NC_010612.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 2770907 mutB 6226567 mutB Mycobacterium marinum M methylmalonyl-CoA mutase YP_001850607.1 2768646 D 216594 CDS YP_001850608.1 183982317 6226568 2770975..2771985 1 NC_010612.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 2771985 6226568 MMAR_2304 Mycobacterium marinum M arginine/ornithine transport system ATPase YP_001850608.1 2770975 D 216594 CDS YP_001850609.1 183982318 6226569 2772049..2773335 1 NC_010612.1 function unknown, but supposed involvement in lipid metabolism; esterase LipL 2773335 lipL 6226569 lipL Mycobacterium marinum M esterase LipL YP_001850609.1 2772049 D 216594 CDS YP_001850610.1 183982319 6226570 complement(2773355..2773567) 1 NC_010612.1 function unknown. contains Cdd pfam07311, DUF1458, protein of unknown function (DUF1458). this family consists of several hypothetical bacterial proteins as well as one archaeal sequence. members of this family are typically of around 70 residues in length. the function of this family is unknown; hypothetical protein 2773567 6226570 MMAR_2306 Mycobacterium marinum M hypothetical protein YP_001850610.1 2773355 R 216594 CDS YP_001850611.1 183982320 6226571 complement(2773695..2775599) 1 NC_010612.1 hypothetical protein 2775599 6226571 MMAR_2307 Mycobacterium marinum M hypothetical protein YP_001850611.1 2773695 R 216594 CDS YP_001850612.1 183982321 6226572 complement(2775619..2776110) 1 NC_010612.1 hypothetical protein 2776110 6226572 MMAR_2308 Mycobacterium marinum M hypothetical protein YP_001850612.1 2775619 R 216594 CDS YP_001850613.1 183982322 6226573 2776434..2777690 1 NC_010612.1 involved in lipooligosaccharide biosynthesis [catalytic activity: UDP-glucose + 2 NAD+ + H2O = UDP- glucuronate + 2 NADH]. belongs to UDP-glucose/GDP-mannose dehydrogenase family; UDP-glucose 6-dehydrogenase, UdgL 2777690 udgL 6226573 udgL Mycobacterium marinum M UDP-glucose 6-dehydrogenase, UdgL YP_001850613.1 2776434 D 216594 CDS YP_001850614.1 183982323 6226574 2777687..2778706 1 NC_010612.1 involved in galactofuranosyl biosynthesis: converts UDO-GlcP to UDP-GalP [catalytic activity: UDP- glucopyranose = UDP-galactopyranose]; UDP-glucose 4-epimerase 2778706 galE5 6226574 galE5 Mycobacterium marinum M UDP-glucose 4-epimerase YP_001850614.1 2777687 D 216594 CDS YP_001850615.1 183982324 6226575 2778736..2780229 1 NC_010612.1 contains Cdd pfam00535 glycosyl transferase. diverse family, transferring sugar from UDP-glucose, UDP-N- acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family protein 2780229 6226575 MMAR_2311 Mycobacterium marinum M glycosyl transferase family protein YP_001850615.1 2778736 D 216594 CDS YP_001850616.1 183982325 6226576 2780315..2781247 1 NC_010612.1 contains Cdd COG0451 nucleoside-diphosphate-sugar epimerases [cell envelope biogenesis, outer membrane - carbohydrate transport and metabolism]; nucleoside-diphosphate-sugar epimerase 2781247 6226576 MMAR_2312 Mycobacterium marinum M nucleoside-diphosphate-sugar epimerase YP_001850616.1 2780315 D 216594 CDS YP_001850617.1 183982326 6226577 2781541..2782575 1 NC_010612.1 involved in the final assembly of the M. marinum LOS-IV glycolipid; glycosyltransferase, LosA 2782575 losA 6226577 losA Mycobacterium marinum M glycosyltransferase, LosA YP_001850617.1 2781541 D 216594 CDS YP_001850618.1 183982327 6226578 2782572..2783393 1 NC_010612.1 function unknown; hypothetical protein 2783393 6226578 MMAR_2314 Mycobacterium marinum M hypothetical protein YP_001850618.1 2782572 D 216594 CDS YP_001850619.1 183982328 6226579 2783614..2784486 1 NC_010612.1 methylation of unknown substrate; methyltransferase 2784486 6226579 MMAR_2315 Mycobacterium marinum M methyltransferase YP_001850619.1 2783614 D 216594 CDS YP_001850620.1 183982329 6226580 2784600..2785247 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulator 2785247 6226580 MMAR_2316 Mycobacterium marinum M transcriptional regulator YP_001850620.1 2784600 D 216594 CDS YP_001850621.1 183982330 6226581 2785253..2786098 1 NC_010612.1 O-methyltransferase 2786098 6226581 MMAR_2317 Mycobacterium marinum M O-methyltransferase YP_001850621.1 2785253 D 216594 CDS YP_001850622.1 183982331 6226582 2786359..2787267 1 NC_010612.1 hypothetical protein 2787267 6226582 MMAR_2318 Mycobacterium marinum M hypothetical protein YP_001850622.1 2786359 D 216594 CDS YP_001850623.1 183982332 6226583 complement(2787300..2788937) 1 NC_010612.1 hypothetical protein 2788937 6226583 MMAR_2319 Mycobacterium marinum M hypothetical protein YP_001850623.1 2787300 R 216594 CDS YP_001850624.1 183982333 6226584 complement(2788950..2790098) 1 NC_010612.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 2790098 wecE 6226584 wecE Mycobacterium marinum M TDP-4-oxo-6-deoxy-D-glucose transaminase YP_001850624.1 2788950 R 216594 CDS YP_001850625.1 183982334 6226585 complement(2790240..2790905) 1 NC_010612.1 function unknown but contains left-handed parallel beta-helix, with 4 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[Stav]-X- [Liv]-[gaed]-X). proteins containing hexapeptide repeats are often enzymes showing acyl-transferase activity; acyltransferase 2790905 6226585 MMAR_2321 Mycobacterium marinum M acyltransferase YP_001850625.1 2790240 R 216594 CDS YP_001850626.1 183982335 6226586 complement(2790902..2791537) 1 NC_010612.1 hypothetical protein 2791537 6226586 MMAR_2322 Mycobacterium marinum M hypothetical protein YP_001850626.1 2790902 R 216594 CDS YP_001850627.1 183982336 6226587 complement(2791869..2793755) 1 NC_010612.1 hypothetical protein 2793755 6226587 MMAR_2323 Mycobacterium marinum M hypothetical protein YP_001850627.1 2791869 R 216594 CDS YP_001850628.1 183982337 6226588 2793975..2794268 1 NC_010612.1 hypothetical protein 2794268 6226588 MMAR_2324 Mycobacterium marinum M hypothetical protein YP_001850628.1 2793975 D 216594 CDS YP_001850629.1 183982338 6226589 complement(2794381..2795019) 1 NC_010612.1 hypothetical protein 2795019 6226589 MMAR_2325 Mycobacterium marinum M hypothetical protein YP_001850629.1 2794381 R 216594 CDS YP_001850630.1 183982339 6226590 2795179..2795601 1 NC_010612.1 hypothetical protein 2795601 6226590 MMAR_2326 Mycobacterium marinum M hypothetical protein YP_001850630.1 2795179 D 216594 CDS YP_001850631.1 183982340 6226591 2795598..2797166 1 NC_010612.1 hypothetical protein 2797166 6226591 MMAR_2327 Mycobacterium marinum M hypothetical protein YP_001850631.1 2795598 D 216594 CDS YP_001850632.1 183982341 6226592 complement(2797219..2798496) 1 NC_010612.1 function unknown role in carbohydrate metabolism; putative sugar kinase 2798496 6226592 MMAR_2328 Mycobacterium marinum M putative sugar kinase YP_001850632.1 2797219 R 216594 CDS YP_001850633.1 183982342 6226593 complement(2798468..2799550) 1 NC_010612.1 involved at the second step in the biosynthesis of chorismate within the biosynthesis of aromatic amino acids (the shikimate pathway) [catalytic activity: 7-phospho-3- deoxy-arabino-heptulosonate = 3-dehydroquinate + orthophosphate]; 3-dehydroquinate synthase 2799550 aroB_2 6226593 aroB_2 Mycobacterium marinum M 3-dehydroquinate synthase YP_001850633.1 2798468 R 216594 CDS YP_001850634.1 183982343 6226594 complement(2799547..2800236) 1 NC_010612.1 short chain dehydrogenase 2800236 6226594 MMAR_2330 Mycobacterium marinum M short chain dehydrogenase YP_001850634.1 2799547 R 216594 CDS YP_001850635.1 183982344 6226595 complement(2800374..2801174) 1 NC_010612.1 hypothetical protein 2801174 6226595 MMAR_2331 Mycobacterium marinum M hypothetical protein YP_001850635.1 2800374 R 216594 CDS YP_001850636.1 183982345 6226596 complement(2801343..2803163) 1 NC_010612.1 involved in valine and isoleucine biosynthesis (at the first step) [catalytic activity: 2-acetolactate + CO(2) = 2 pyruvate]; acetolactate synthase large subunit IlvB 2803163 ilvB1_3 6226596 ilvB1_3 Mycobacterium marinum M acetolactate synthase large subunit IlvB YP_001850636.1 2801343 R 216594 CDS YP_001850637.1 183982346 6226597 complement(2803160..2804116) 1 NC_010612.1 function unknown. maybe involved in cell wall biogenesis; glycosyltransferase, WcaA 2804116 wcaA 6226597 wcaA Mycobacterium marinum M glycosyltransferase, WcaA YP_001850637.1 2803160 R 216594 CDS YP_001850638.1 183982347 6226598 complement(2804113..2804850) 1 NC_010612.1 function unknown - may be involved in [cell envelope biogenesis by transfer of nucleotides onto phosphosugars; nucleotidyltransferase 2804850 6226598 MMAR_2334 Mycobacterium marinum M nucleotidyltransferase YP_001850638.1 2804113 R 216594 CDS YP_001850639.1 183982348 6226599 2805067..2806410 1 NC_010612.1 may be involved in regulation of cell wall biogenesis; pyridoxal phosphate-dependent enzyme 2806410 6226599 MMAR_2335 Mycobacterium marinum M pyridoxal phosphate-dependent enzyme YP_001850639.1 2805067 D 216594 CDS YP_001850640.1 183982349 6226600 2806413..2807429 1 NC_010612.1 possibly involved in galactose metabolism [catalytic activity: UDP-glucose = UDP-galactose]; UDP-glucose 4-epimerase 2807429 galE6 6226600 galE6 Mycobacterium marinum M UDP-glucose 4-epimerase YP_001850640.1 2806413 D 216594 CDS YP_001850641.1 183982350 6226601 2807426..2807926 1 NC_010612.1 hypothetical protein 2807926 6226601 MMAR_2337 Mycobacterium marinum M hypothetical protein YP_001850641.1 2807426 D 216594 CDS YP_001850642.1 183982351 6226602 complement(2807893..2809512) 1 NC_010612.1 hypothetical protein 2809512 6226602 MMAR_2338 Mycobacterium marinum M hypothetical protein YP_001850642.1 2807893 R 216594 CDS YP_001850643.1 183982352 6226603 complement(2809852..2810508) 1 NC_010612.1 SAM-dependent methyltransferase 2810508 6226603 MMAR_2339 Mycobacterium marinum M SAM-dependent methyltransferase YP_001850643.1 2809852 R 216594 CDS YP_001850644.1 183982353 6226604 complement(2810562..2816834) 1 NC_010612.1 synthesis of unknown metabolite. single module with the following domains: KS, ATP, ER, KR, ACP; polyketide synthase Pks5 2816834 pks5 6226604 pks5 Mycobacterium marinum M polyketide synthase Pks5 YP_001850644.1 2810562 R 216594 CDS YP_001850645.1 183982354 6226605 2817295..2819052 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2819052 fadD25 6226605 fadD25 Mycobacterium marinum M acyl-CoA synthetase YP_001850645.1 2817295 D 216594 CDS YP_001850646.1 183982355 6226606 complement(2819321..2823694) 1 NC_010612.1 thought to be involved in fatty acid transport; MmpL family transport protein 2823694 6226606 MMAR_2342 Mycobacterium marinum M MmpL family transport protein YP_001850646.1 2819321 R 216594 CDS YP_001850647.1 183982356 6226607 complement(2824080..2825516) 1 NC_010612.1 function unknown. contains a non-ribosomal peptide (Nrp) condensation domain. possibly involved in the synthesis of a hybrid NRP-PKS; hypothetical protein 2825516 6226607 MMAR_2343 Mycobacterium marinum M hypothetical protein YP_001850647.1 2824080 R 216594 CDS YP_001850648.1 183982357 6226608 complement(2825569..2831823) 1 NC_010612.1 function unknown, catalyzes the elongation of N- fatty acyl-CoA with methylamalonyl-CoA. single module with domain structure: KS, ATP, DH, ER, KR, ACP; polyketide synthase 2831823 pks5_1 6226608 pks5_1 Mycobacterium marinum M polyketide synthase YP_001850648.1 2825569 R 216594 CDS YP_001850649.1 183982358 6226609 2832079..2832642 1 NC_010612.1 hypothetical protein 2832642 6226609 MMAR_2345 Mycobacterium marinum M hypothetical protein YP_001850649.1 2832079 D 216594 CDS YP_001850650.1 183982359 6226610 2832775..2833908 1 NC_010612.1 function unknown; identity with NPD, 2-nitropropane dioxygenase. members of this family catalyse the denitrification of a number of nitroalkanes using either fad or FMN as a cofactor; dioxygenase 2833908 6226610 MMAR_2346 Mycobacterium marinum M dioxygenase YP_001850650.1 2832775 D 216594 CDS YP_001850651.1 183982360 6226611 2834185..2834352 1 NC_010612.1 hypothetical protein 2834352 6226611 MMAR_2347 Mycobacterium marinum M hypothetical protein YP_001850651.1 2834185 D 216594 CDS YP_001850652.1 183982361 6226612 2834541..2834774 1 NC_010612.1 hypothetical protein 2834774 6226612 MMAR_2348 Mycobacterium marinum M hypothetical protein YP_001850652.1 2834541 D 216594 CDS YP_001850653.1 183982362 6226613 2835032..2835799 1 NC_010612.1 possibly involved in cell wall arabinogalactan linker formation: uses dTDP-L-rhamnose as substrate to insert the rhamnosyl residue into the cell wall; rhamnosyl transferase WbbL2 2835799 wbbL2 6226613 wbbL2 Mycobacterium marinum M rhamnosyl transferase WbbL2 YP_001850653.1 2835032 D 216594 CDS YP_001850654.1 183982363 6226614 complement(2835845..2836516) 1 NC_010612.1 function unknown, domain identity to UbiG, 2- polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylases; methylase 2836516 6226614 MMAR_2350 Mycobacterium marinum M methylase YP_001850654.1 2835845 R 216594 CDS YP_001850655.1 183982364 6226615 2836618..2837367 1 NC_010612.1 function unknown. contains Cdd pfam00535, glycos_transf_2, glycosyl transferase. diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family protein 2837367 6226615 MMAR_2351 Mycobacterium marinum M glycosyl transferase family protein YP_001850655.1 2836618 D 216594 CDS YP_001850656.1 183982365 6226616 complement(2837485..2838219) 1 NC_010612.1 hypothetical protein 2838219 6226616 MMAR_2352 Mycobacterium marinum M hypothetical protein YP_001850656.1 2837485 R 216594 CDS YP_001850657.1 183982366 6226617 complement(2838244..2839488) 1 NC_010612.1 function unknown. contains Cdd COG1819, glycosyl transferases, related to UDP-glucuronosyltransferase [carbohydrate transport and metabolism / signal transduction mechanisms]; UDP-glycosyltransferase 2839488 6226617 MMAR_2353 Mycobacterium marinum M UDP-glycosyltransferase YP_001850657.1 2838244 R 216594 CDS YP_001850658.1 183982367 6226618 complement(2839552..2840925) 1 NC_010612.1 function unknown. similarity to Cdd pfam03007. uncharacterised protein family (UPF0089). this family of uncharacterised proteins is greatly expanded in mycobacterium tuberculosis. the most conserved region of the proteins contains conserved histidine and aspartate residues suggesting a possible metal binding site suggestive of a protease activity; hypothetical protein 2840925 6226618 MMAR_2354 Mycobacterium marinum M hypothetical protein YP_001850658.1 2839552 R 216594 CDS YP_001850659.1 183982368 6226619 complement(2840940..2842448) 1 NC_010612.1 function unknown. thought to be involved in lipid metabolism; polyketide synthase associated protein PapA3 2842448 papA3 6226619 papA3 Mycobacterium marinum M polyketide synthase associated protein PapA3 YP_001850659.1 2840940 R 216594 CDS YP_001850660.1 183982369 6226620 2843147..2846347 1 NC_010612.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 2846347 ileS 6226620 ileS Mycobacterium marinum M isoleucyl-tRNA synthetase YP_001850660.1 2843147 D 216594 CDS YP_001850661.1 183982370 6226621 complement(2846352..2847404) 1 NC_010612.1 function unknown; hypothetical protein 2847404 6226621 MMAR_2357 Mycobacterium marinum M hypothetical protein YP_001850661.1 2846352 R 216594 CDS YP_001850662.1 183982371 6226622 complement(2847460..2848032) 1 NC_010612.1 function unknown. partial Cdd COG0030, KsgA, dimethyladenosine transferase (rRNA methylation) [translation, ribosomal structure and biogenesis]; hypothetical protein 2848032 6226622 MMAR_2358 Mycobacterium marinum M hypothetical protein YP_001850662.1 2847460 R 216594 CDS YP_001850663.1 183982372 6226623 2848099..2849511 1 NC_010612.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 2849511 dinP_1 6226623 dinP_1 Mycobacterium marinum M DNA polymerase IV YP_001850663.1 2848099 D 216594 CDS YP_001850664.1 183982373 6226624 complement(2849476..2850432) 1 NC_010612.1 conversion of asparagine to aspartate; L-aparaginase AnsA 2850432 ansA 6226624 ansA Mycobacterium marinum M L-aparaginase AnsA YP_001850664.1 2849476 R 216594 CDS YP_001850665.1 183982374 6226625 2850508..2851098 1 NC_010612.1 this protein specifically catalyzes the removal of signal peptides from prolipoproteins [catalytic activity : cleavage of N-terminal leader sequences from membrane prolipoproteins; lipoprotein signal peptidase LspA 2851098 lspA 6226625 lspA Mycobacterium marinum M lipoprotein signal peptidase LspA YP_001850665.1 2850508 D 216594 CDS YP_001850666.1 183982375 6226626 2851113..2852024 1 NC_010612.1 pseudouridine synthase (pseudouridylate synthase) (uracil hydrolyase)[catalytic activity] uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H(2)O; RluA family pseudouridine synthase 2852024 6226626 MMAR_2362 Mycobacterium marinum M RluA family pseudouridine synthase YP_001850666.1 2851113 D 216594 CDS YP_001850667.1 183982376 6226627 complement(2852033..2852803) 1 NC_010612.1 function unknown. contains partial Cdd COG2226, UbiE, methylase involved in ubiquinone/menaquinone biosynthesis; hypothetical protein 2852803 6226627 MMAR_2363 Mycobacterium marinum M hypothetical protein YP_001850667.1 2852033 R 216594 CDS YP_001850668.1 183982377 6226628 complement(2853097..2853732) 1 NC_010612.1 function unknown; lipoprotein, LprL 2853732 lprL 6226628 lprL Mycobacterium marinum M lipoprotein, LprL YP_001850668.1 2853097 R 216594 CDS YP_001850669.1 183982378 6226629 complement(2853816..2854226) 1 NC_010612.1 oxygen transport. this family of HemE binding proteins are found mainly in bacteria; globin family protein 2854226 glbN 6226629 glbN Mycobacterium marinum M globin family protein YP_001850669.1 2853816 R 216594 CDS YP_001850670.1 183982379 6226630 2854465..2855481 1 NC_010612.1 thought to reduce acyl-CoA esters of fatty acids to fatty aldehydes; fatty acyl-CoA reductase 2855481 6226630 MMAR_2366 Mycobacterium marinum M fatty acyl-CoA reductase YP_001850670.1 2854465 D 216594 CDS YP_001850671.1 183982380 6226631 2855486..2856289 1 NC_010612.1 possibly involvement in lipid metabolism; ketoacyl reductase 2856289 6226631 MMAR_2367 Mycobacterium marinum M ketoacyl reductase YP_001850671.1 2855486 D 216594 CDS YP_001850672.1 183982381 6226632 2856409..2856840 1 NC_010612.1 hypothetical protein 2856840 6226632 MMAR_2368 Mycobacterium marinum M hypothetical protein YP_001850672.1 2856409 D 216594 CDS YP_001850673.1 183982382 6226633 2856907..2860449 1 NC_010612.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 2860449 dnaE 6226633 dnaE Mycobacterium marinum M DNA polymerase III subunit alpha YP_001850673.1 2856907 D 216594 CDS YP_001850674.1 183982383 6226634 2860576..2862402 1 NC_010612.1 probably involved in lipid degradation; fatty-acid-CoA ligase FadD11 2862402 fadD11 6226634 fadD11 Mycobacterium marinum M fatty-acid-CoA ligase FadD11 YP_001850674.1 2860576 D 216594 CDS YP_001850675.1 183982384 6226635 2862417..2864291 1 NC_010612.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 2864291 plsB1 6226635 plsB1 Mycobacterium marinum M glycerol-3-phosphate acyltransferase YP_001850675.1 2862417 D 216594 CDS YP_001850676.1 183982385 6226636 complement(2864299..2864529) 1 NC_010612.1 function unknown; hypothetical protein 2864529 6226636 MMAR_2372 Mycobacterium marinum M hypothetical protein YP_001850676.1 2864299 R 216594 CDS YP_001850677.1 183982386 6226637 2864632..2865069 1 NC_010612.1 function unknown. contains Cdd pfam04075, domain of unknown function (DUF385). family of mycobacterium tuberculosis proteins; hypothetical protein 2865069 6226637 MMAR_2373 Mycobacterium marinum M hypothetical protein YP_001850677.1 2864632 D 216594 CDS YP_001850678.1 183982387 6226638 2865103..2866383 1 NC_010612.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 2866383 ilvA 6226638 ilvA Mycobacterium marinum M threonine dehydratase YP_001850678.1 2865103 D 216594 CDS YP_001850679.1 183982388 6226639 complement(2866411..2867055) 1 NC_010612.1 hypothetical protein 2867055 6226639 MMAR_2375 Mycobacterium marinum M hypothetical protein YP_001850679.1 2866411 R 216594 CDS YP_001850680.1 183982389 6226640 2867097..2868422 1 NC_010612.1 involved in transcriptional mechanism; GntR family transcriptional regulator 2868422 6226640 MMAR_2376 Mycobacterium marinum M GntR family transcriptional regulator YP_001850680.1 2867097 D 216594 CDS YP_001850681.1 183982390 6226641 complement(2868435..2870198) 1 NC_010612.1 involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway); maltooligosyltrehalose trehalohydrolase, TreZ 2870198 treZ 6226641 treZ Mycobacterium marinum M maltooligosyltrehalose trehalohydrolase, TreZ YP_001850681.1 2868435 R 216594 CDS YP_001850682.1 183982391 6226642 complement(2870195..2872492) 1 NC_010612.1 involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway); maltooligosyltrehalose synthase TreY 2872492 treY 6226642 treY Mycobacterium marinum M maltooligosyltrehalose synthase TreY YP_001850682.1 2870195 R 216594 CDS YP_001850683.1 183982392 6226643 complement(2872496..2874673) 1 NC_010612.1 possibly involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway); maltooligosyltrehalose synthase TreX 2874673 treX 6226643 treX Mycobacterium marinum M maltooligosyltrehalose synthase TreX YP_001850683.1 2872496 R 216594 CDS YP_001850684.1 183982393 6226644 complement(2874773..2876938) 1 NC_010612.1 hypothetical protein 2876938 6226644 MMAR_2380 Mycobacterium marinum M hypothetical protein YP_001850684.1 2874773 R 216594 CDS YP_001850685.1 183982394 6226645 complement(2877046..2877825) 1 NC_010612.1 possible inv protein, probably exported as has QQAPV repeats at c-terminus; inv protein 2877825 6226645 MMAR_2381 Mycobacterium marinum M inv protein YP_001850685.1 2877046 R 216594 CDS YP_001850686.1 183982395 6226646 complement(2878171..2878614) 1 NC_010612.1 hypothetical protein 2878614 6226646 MMAR_2382 Mycobacterium marinum M hypothetical protein YP_001850686.1 2878171 R 216594 CDS YP_001850687.1 183982396 6226647 2878708..2880021 1 NC_010612.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 2880021 bioA 6226647 bioA Mycobacterium marinum M adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_001850687.1 2878708 D 216594 CDS YP_001850688.1 183982397 6226648 2880028..2881197 1 NC_010612.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 2881197 bioF1 6226648 bioF1 Mycobacterium marinum M 8-amino-7-oxononanoate synthase YP_001850688.1 2880028 D 216594 CDS YP_001850689.1 183982398 6226649 2881194..2881874 1 NC_010612.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 2881874 bioD 6226649 bioD Mycobacterium marinum M dithiobiotin synthetase YP_001850689.1 2881194 D 216594 CDS YP_001850690.1 183982399 6226650 2881876..2882385 1 NC_010612.1 hypothetical protein 2882385 6226650 MMAR_2386 Mycobacterium marinum M hypothetical protein YP_001850690.1 2881876 D 216594 CDS YP_001850691.1 183982400 6226651 2882538..2883587 1 NC_010612.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 2883587 bioB 6226651 bioB Mycobacterium marinum M biotin synthase YP_001850691.1 2882538 D 216594 CDS YP_001850692.1 183982401 6226652 2883603..2883830 1 NC_010612.1 hypothetical protein 2883830 6226652 MMAR_5574 Mycobacterium marinum M hypothetical protein YP_001850692.1 2883603 D 216594 CDS YP_001850693.1 183982402 6226653 2883953..2884525 1 NC_010612.1 hypothetical protein 2884525 6226653 MMAR_2388 Mycobacterium marinum M hypothetical protein YP_001850693.1 2883953 D 216594 CDS YP_001850694.1 183982403 6226654 complement(2884571..2885938) 1 NC_010612.1 hypothetical protein 2885938 6226654 MMAR_2389 Mycobacterium marinum M hypothetical protein YP_001850694.1 2884571 R 216594 CDS YP_001850695.1 183982404 6226655 complement(2886268..2886975) 1 NC_010612.1 function unknown, domain identity to ADP-ribose pyrophosphatases, possible role in nucleotide transport and metabolism; hypothetical protein 2886975 6226655 MMAR_2390 Mycobacterium marinum M hypothetical protein YP_001850695.1 2886268 R 216594 CDS YP_001850696.1 183982405 6226656 2887023..2888081 1 NC_010612.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 2888081 nadA 6226656 nadA Mycobacterium marinum M quinolinate synthetase YP_001850696.1 2887023 D 216594 CDS YP_001850697.1 183982406 6226657 2888078..2889652 1 NC_010612.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2889652 nadB 6226657 nadB Mycobacterium marinum M L-aspartate oxidase YP_001850697.1 2888078 D 216594 CDS YP_001850698.1 183982407 6226658 2889652..2890509 1 NC_010612.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 2890509 nadC 6226658 nadC Mycobacterium marinum M nicotinate-nucleotide pyrophosphorylase YP_001850698.1 2889652 D 216594 CDS YP_001850699.1 183982408 6226659 complement(2890571..2890981) 1 NC_010612.1 hypothetical protein 2890981 6226659 MMAR_2394 Mycobacterium marinum M hypothetical protein YP_001850699.1 2890571 R 216594 CDS YP_001850700.1 183982409 6226660 2891066..2892409 1 NC_010612.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2892409 hisD 6226660 hisD Mycobacterium marinum M histidinol dehydrogenase YP_001850700.1 2891066 D 216594 CDS YP_001850701.1 183982410 6226661 2892406..2893554 1 NC_010612.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2893554 hisC1 6226661 hisC1 Mycobacterium marinum M histidinol-phosphate aminotransferase YP_001850701.1 2892406 D 216594 CDS YP_001850702.1 183982411 6226662 2893551..2894183 1 NC_010612.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 2894183 hisB 6226662 hisB Mycobacterium marinum M imidazoleglycerol-phosphate dehydratase YP_001850702.1 2893551 D 216594 CDS YP_001850703.1 183982412 6226663 2894180..2894812 1 NC_010612.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2894812 hisH 6226663 hisH Mycobacterium marinum M imidazole glycerol phosphate synthase subunit HisH YP_001850703.1 2894180 D 216594 CDS YP_001850704.1 183982413 6226664 2894809..2895558 1 NC_010612.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A 2895558 hisA 6226664 hisA Mycobacterium marinum M phosphoribosyl isomerase A YP_001850704.1 2894809 D 216594 CDS YP_001850705.1 183982414 6226665 2895565..2896377 1 NC_010612.1 involved in inositol phosphate metabolism. it is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. key enzyme of the phosphatidyl inositol signaling pathway [catalytic activity: inositol 1(or 4)-monophosphate + H(2)O = inositol + orthophosphate]; inositol-monophosphatase ImpA 2896377 impA 6226665 impA Mycobacterium marinum M inositol-monophosphatase ImpA YP_001850705.1 2895565 D 216594 CDS YP_001850706.1 183982415 6226666 2896379..2897164 1 NC_010612.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2897164 hisF 6226666 hisF Mycobacterium marinum M imidazole glycerol phosphate synthase subunit HisF YP_001850706.1 2896379 D 216594 CDS YP_001850707.1 183982416 6226667 2897161..2897496 1 NC_010612.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 2897496 hisI 6226667 hisI Mycobacterium marinum M phosphoribosyl-AMP cyclohydrolase YP_001850707.1 2897161 D 216594 CDS YP_001850708.1 183982417 6226668 complement(2897619..2898710) 1 NC_010612.1 function unknown; deacylase 2898710 6226668 MMAR_2403 Mycobacterium marinum M deacylase YP_001850708.1 2897619 R 216594 CDS YP_001850709.1 183982418 6226669 complement(2898715..2899059) 1 NC_010612.1 hypothetical protein 2899059 6226669 MMAR_2404 Mycobacterium marinum M hypothetical protein YP_001850709.1 2898715 R 216594 CDS YP_001850710.1 183982419 6226670 complement(2899081..2901285) 1 NC_010612.1 function unknown, possibly involved in secondary metabolites biosynthesis, transport, and catabolism / inorganic ion transport and metabolism; cyanophycinase CphB 2901285 cphB 6226670 cphB Mycobacterium marinum M cyanophycinase CphB YP_001850710.1 2899081 R 216594 CDS YP_001850711.1 183982420 6226671 complement(2901282..2904017) 1 NC_010612.1 catalyze the formation of cyanophycin which may act to store excess nitrogen; cyanophycin synthetase 2904017 6226671 MMAR_2406 Mycobacterium marinum M cyanophycin synthetase YP_001850711.1 2901282 R 216594 CDS YP_001850712.1 183982421 6226672 2904612..2906105 1 NC_010612.1 thought to be involved in transport of cationic amino acid (especially arginine and ornithine) across the membrane. responsible for the translocation of the substrate across the membrane; cationic amino acid transport integral membrane protein, RocE 2906105 rocE_1 6226672 rocE_1 Mycobacterium marinum M cationic amino acid transport integral membrane protein, RocE YP_001850712.1 2904612 D 216594 CDS YP_001850713.1 183982422 6226673 complement(2906309..2907823) 1 NC_010612.1 involved in signal transduction (via phosphorylation). thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; anchored-membrane serine/threonine-protein kinase PknF 2907823 pknF_1 6226673 pknF_1 Mycobacterium marinum M anchored-membrane serine/threonine-protein kinase PknF YP_001850713.1 2906309 R 216594 CDS YP_001850714.1 183982423 6226674 2908067..2909149 1 NC_010612.1 involved in transport of ions (presumably calcium) across the membrane. responsible for the translocation of the substrate across the membrane; ionic transporter integral membrane protein ChaA 2909149 chaA 6226674 chaA Mycobacterium marinum M ionic transporter integral membrane protein ChaA YP_001850714.1 2908067 D 216594 CDS YP_001850715.1 183982424 6226675 complement(2909174..2909632) 1 NC_010612.1 peroxide detoxification; peroxidoxin BcpB 2909632 bcpB 6226675 bcpB Mycobacterium marinum M peroxidoxin BcpB YP_001850715.1 2909174 R 216594 CDS YP_001850716.1 183982425 6226676 2909683..2911221 1 NC_010612.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 2911221 trpE 6226676 trpE Mycobacterium marinum M anthranilate synthase component I YP_001850716.1 2909683 D 216594 CDS YP_001850717.1 183982426 6226677 2911262..2911909 1 NC_010612.1 hypothetical protein 2911909 6226677 MMAR_2412 Mycobacterium marinum M hypothetical protein YP_001850717.1 2911262 D 216594 CDS YP_001850718.1 183982427 6226678 2911999..2912817 1 NC_010612.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 2912817 trpC 6226678 trpC Mycobacterium marinum M indole-3-glycerol-phosphate synthase YP_001850718.1 2911999 D 216594 CDS YP_001850719.1 183982428 6226679 2912853..2914130 1 NC_010612.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 2914130 trpB 6226679 trpB Mycobacterium marinum M tryptophan synthase subunit beta YP_001850719.1 2912853 D 216594 CDS YP_001850720.1 183982429 6226680 2914133..2914942 1 NC_010612.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 2914942 trpA 6226680 trpA Mycobacterium marinum M tryptophan synthase subunit alpha YP_001850720.1 2914133 D 216594 CDS YP_001850721.1 183982430 6226681 2914939..2917083 1 NC_010612.1 prolipoprotein modification; prolipoprotein diacylglyceryl transferases Lgt 2917083 lgt 6226681 lgt Mycobacterium marinum M prolipoprotein diacylglyceryl transferases Lgt YP_001850721.1 2914939 D 216594 CDS YP_001850722.1 183982431 6226682 2917147..2917542 1 NC_010612.1 hypothetical protein 2917542 6226682 MMAR_2417 Mycobacterium marinum M hypothetical protein YP_001850722.1 2917147 D 216594 CDS YP_001850723.1 183982432 6226683 2917529..2917972 1 NC_010612.1 hypothetical protein 2917972 6226683 MMAR_2418 Mycobacterium marinum M hypothetical protein YP_001850723.1 2917529 D 216594 CDS YP_001850724.1 183982433 6226684 complement(2917994..2918749) 1 NC_010612.1 hydrolysis of cutin; cutinase Cut1 2918749 cut1 6226684 cut1 Mycobacterium marinum M cutinase Cut1 YP_001850724.1 2917994 R 216594 CDS YP_001850725.1 183982434 6226685 2919156..2920574 1 NC_010612.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2920574 pykA 6226685 pykA Mycobacterium marinum M pyruvate kinase YP_001850725.1 2919156 D 216594 CDS YP_001850726.1 183982435 6226686 2920674..2921579 1 NC_010612.1 involved in fatty acid metabolism; acyl-CoA thioesterase II TesB1 2921579 tesB1 6226686 tesB1 Mycobacterium marinum M acyl-CoA thioesterase II TesB1 YP_001850726.1 2920674 D 216594 CDS YP_001850727.1 183982436 6226687 2921705..2923111 1 NC_010612.1 hypothetical protein 2923111 6226687 MMAR_2422 Mycobacterium marinum M hypothetical protein YP_001850727.1 2921705 D 216594 CDS YP_001850728.1 183982437 6226688 complement(2923073..2924767) 1 NC_010612.1 involved in active transport across the membrane of component linked with the assembly of cytochrome: involved in cytochrome biogenesis (aerobic respiration). responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; cytochrome assembly ABC transporter ATP-binding protein CydC 2924767 cydC 6226688 cydC Mycobacterium marinum M cytochrome assembly ABC transporter ATP-binding protein CydC YP_001850728.1 2923073 R 216594 CDS YP_001850729.1 183982438 6226689 complement(2924754..2926352) 1 NC_010612.1 involved in active transport across the membrane of component linked with the assembly of cytochrome: involved in cytochrome biogenesis (aerobic respiration). responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; cytochrome assembly ABC transporter ATP-binding protein CydD 2926352 cydD 6226689 cydD Mycobacterium marinum M cytochrome assembly ABC transporter ATP-binding protein CydD YP_001850729.1 2924754 R 216594 CDS YP_001850730.1 183982439 6226690 complement(2926439..2927479) 1 NC_010612.1 involved in the respiratory chain (at the terminal step): aerobic respiration. cytochrome D terminal oxidase complex is the component of the aerobic respiratory chain that is supposed predominated when cells are grown at low aeration [catalytic activity: ubiquinol-8 + O(2) = ubiquinone-8 + H(2)O]; integral membrane cytochrome D ubiquinol oxidase (subunit II) CydB 2927479 cydB 6226690 cydB Mycobacterium marinum M integral membrane cytochrome D ubiquinol oxidase (subunit II) CydB YP_001850730.1 2926439 R 216594 CDS YP_001850731.1 183982440 6226691 complement(2927527..2928984) 1 NC_010612.1 involved in the respiratory chain (at the terminal step): aerobic respiration. cytochrome D terminal oxidase complex is the component of the aerobic respiratory chain that is supposed predominated when cells are grown at low aeration [catalytic activity: ubiquinol-8 + O(2) = ubiquinone-8 + H(2)O]; integral membrane cytochrome D ubiquinol oxidase (subunit I) CydA 2928984 cydA 6226691 cydA Mycobacterium marinum M integral membrane cytochrome D ubiquinol oxidase (subunit I) CydA YP_001850731.1 2927527 R 216594 CDS YP_001850732.1 183982441 6226692 complement(2929088..2929666) 1 NC_010612.1 hypothetical protein 2929666 6226692 MMAR_2427 Mycobacterium marinum M hypothetical protein YP_001850732.1 2929088 R 216594 CDS YP_001850733.1 183982442 6226693 complement(2929729..2931069) 1 NC_010612.1 involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]; membrane-anchored adenylyl cyclase Cya 2931069 cya 6226693 cya Mycobacterium marinum M membrane-anchored adenylyl cyclase Cya YP_001850733.1 2929729 R 216594 CDS YP_001850734.1 183982443 6226695 2931371..2931988 1 NC_010612.1 sensor part of a two-component regulatory system; two-component system transcriptional regulator 2931988 6226695 MMAR_2429 Mycobacterium marinum M two-component system transcriptional regulator YP_001850734.1 2931371 D 216594 CDS YP_001850735.1 183982444 6226696 complement(2932033..2933235) 1 NC_010612.1 thought to be involved in lipid metabolism; lipid-transfer protein 2933235 6226696 MMAR_2430 Mycobacterium marinum M lipid-transfer protein YP_001850735.1 2932033 R 216594 CDS YP_001850736.1 183982445 6226697 complement(2933235..2933675) 1 NC_010612.1 hypothetical protein 2933675 6226697 MMAR_2431 Mycobacterium marinum M hypothetical protein YP_001850736.1 2933235 R 216594 CDS YP_001850737.1 183982446 6226698 2933779..2936478 1 NC_010612.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 2936478 polA 6226698 polA Mycobacterium marinum M DNA polymerase I YP_001850737.1 2933779 D 216594 CDS YP_001850738.1 183982447 6226699 2936859..2938304 1 NC_010612.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 2938304 rpsA 6226699 rpsA Mycobacterium marinum M 30S ribosomal protein S1 YP_001850738.1 2936859 D 216594 CDS YP_001850739.1 183982448 6226700 2938317..2939543 1 NC_010612.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain; dephospho-CoA kinase/protein folding accessory domain-containing protein 2939543 coaE 6226700 coaE Mycobacterium marinum M dephospho-CoA kinase/protein folding accessory domain-containing protein YP_001850739.1 2938317 D 216594 CDS YP_001850740.1 183982449 6226701 complement(2939661..2940197) 1 NC_010612.1 hypothetical protein 2940197 6226701 MMAR_2435 Mycobacterium marinum M hypothetical protein YP_001850740.1 2939661 R 216594 CDS YP_001850741.1 183982450 6226702 complement(2940260..2940736) 1 NC_010612.1 hypothetical protein 2940736 6226702 MMAR_2436 Mycobacterium marinum M hypothetical protein YP_001850741.1 2940260 R 216594 CDS YP_001850742.1 183982451 6226703 2940886..2943066 1 NC_010612.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 2943066 uvrB 6226703 uvrB Mycobacterium marinum M excinuclease ABC subunit B YP_001850742.1 2940886 D 216594 CDS YP_001850743.1 183982452 6226704 2943103..2944515 1 NC_010612.1 thought to be involved in transport of drug across the membrane (export). drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells); drug efflux membrane protein 2944515 6226704 MMAR_2438 Mycobacterium marinum M drug efflux membrane protein YP_001850743.1 2943103 D 216594 CDS YP_001850744.1 183982453 6226705 complement(2944504..2946219) 1 NC_010612.1 transmembrane protein 2946219 6226705 MMAR_2439 Mycobacterium marinum M transmembrane protein YP_001850744.1 2944504 R 216594 CDS YP_001850745.1 183982454 6226706 2946394..2946834 1 NC_010612.1 function unknown, domain identity to universal stress protein family and to iron-regulated conserved hypothetical protein TB15.3 from M. tuberculosis H37Rv; iron-regulated protein 2946834 6226706 MMAR_2440 Mycobacterium marinum M iron-regulated protein YP_001850745.1 2946394 D 216594 CDS YP_001850746.1 183982455 6226707 2947202..2947594 1 NC_010612.1 hypothetical protein 2947594 6226707 MMAR_2441 Mycobacterium marinum M hypothetical protein YP_001850746.1 2947202 D 216594 CDS YP_001850747.1 183982456 6226708 complement(2947714..2948391) 1 NC_010612.1 hypothetical protein 2948391 6226708 MMAR_2442 Mycobacterium marinum M hypothetical protein YP_001850747.1 2947714 R 216594 CDS YP_001850748.1 183982457 6226709 2948587..2951502 1 NC_010612.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 2951502 uvrA 6226709 uvrA Mycobacterium marinum M excinuclease ABC subunit A YP_001850748.1 2948587 D 216594 CDS YP_001850749.1 183982458 6226710 complement(2951551..2953233) 1 NC_010612.1 involved in signal transduction (via phosphorylation). [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 2953233 6226710 MMAR_2444 Mycobacterium marinum M Ser/Thr protein kinase YP_001850749.1 2951551 R 216594 CDS YP_001850750.1 183982459 6226711 complement(2953226..2953480) 1 NC_010612.1 hypothetical protein 2953480 6226711 MMAR_2445 Mycobacterium marinum M hypothetical protein YP_001850750.1 2953226 R 216594 CDS YP_001850751.1 183982460 6226712 complement(2953617..2955044) 1 NC_010612.1 hypothetical protein 2955044 6226712 MMAR_2446 Mycobacterium marinum M hypothetical protein YP_001850751.1 2953617 R 216594 CDS YP_001850752.1 183982461 6226713 complement(2955106..2958399) 1 NC_010612.1 catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 2958399 lysS 6226713 lysS Mycobacterium marinum M lysyl-tRNA synthetase YP_001850752.1 2955106 R 216594 CDS YP_001850753.1 183982462 6226714 2958937..2959440 1 NC_010612.1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins; initiation factor IF-3 InfC 2959440 infC 6226714 infC Mycobacterium marinum M initiation factor IF-3 InfC YP_001850753.1 2958937 D 216594 CDS YP_001850754.1 183982463 6226715 2959471..2959665 1 NC_010612.1 translation; 50S ribosomal protein L35 2959665 rpmI 6226715 rpmI Mycobacterium marinum M 50S ribosomal protein L35 YP_001850754.1 2959471 D 216594 CDS YP_001850755.1 183982464 6226716 2959736..2960125 1 NC_010612.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 2960125 rplT 6226716 rplT Mycobacterium marinum M 50S ribosomal protein L20 YP_001850755.1 2959736 D 216594 CDS YP_001850756.1 183982465 6226717 2960203..2961030 1 NC_010612.1 rRNA modification; 23S rRNA methyltransferase TsnR 2961030 tsnR 6226717 tsnR Mycobacterium marinum M 23S rRNA methyltransferase TsnR YP_001850756.1 2960203 D 216594 CDS YP_001850757.1 183982466 6226718 complement(2961034..2962074) 1 NC_010612.1 hypothetical protein 2962074 6226718 MMAR_2452 Mycobacterium marinum M hypothetical protein YP_001850757.1 2961034 R 216594 CDS YP_001850758.1 183982467 6226719 2962428..2963369 1 NC_010612.1 PE family protein 2963369 6226719 MMAR_2453 Mycobacterium marinum M PE family protein YP_001850758.1 2962428 D 216594 CDS YP_001850759.1 183982468 6226720 2963444..2964391 1 NC_010612.1 hypothetical protein 2964391 6226720 MMAR_2454 Mycobacterium marinum M hypothetical protein YP_001850759.1 2963444 D 216594 CDS YP_001850760.1 183982469 6226721 2964401..2965183 1 NC_010612.1 transmembrane protein 2965183 6226721 MMAR_2455 Mycobacterium marinum M transmembrane protein YP_001850760.1 2964401 D 216594 CDS YP_001850761.1 183982470 6226722 2965441..2966484 1 NC_010612.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 2966484 pheS 6226722 pheS Mycobacterium marinum M phenylalanyl-tRNA synthetase subunit alpha YP_001850761.1 2965441 D 216594 CDS YP_001850762.1 183982471 6226723 2966484..2968973 1 NC_010612.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 2968973 pheT 6226723 pheT Mycobacterium marinum M phenylalanyl-tRNA synthetase subunit beta YP_001850762.1 2966484 D 216594 CDS YP_001850763.1 183982472 6226724 2969209..2971125 1 NC_010612.1 PE-PGRS family protein 2971125 6226724 MMAR_2458 Mycobacterium marinum M PE-PGRS family protein YP_001850763.1 2969209 D 216594 CDS YP_001850764.1 183982473 6226725 2971419..2973089 1 NC_010612.1 function unknown; PE-PGRS family protein 2973089 6226725 MMAR_2459 Mycobacterium marinum M PE-PGRS family protein YP_001850764.1 2971419 D 216594 CDS YP_001850765.1 183982474 6226726 2973346..2975190 1 NC_010612.1 function unknown; PE-PGRS family protein 2975190 6226726 MMAR_2460 Mycobacterium marinum M PE-PGRS family protein YP_001850765.1 2973346 D 216594 CDS YP_001850766.1 183982475 6226727 2976136..2983359 1 NC_010612.1 PE-PGRS family protein 2983359 6226727 MMAR_2461 Mycobacterium marinum M PE-PGRS family protein YP_001850766.1 2976136 D 216594 CDS YP_001850767.1 183982476 6226728 2983451..2984503 1 NC_010612.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 2984503 argC 6226728 argC Mycobacterium marinum M N-acetyl-gamma-glutamyl-phosphate reductase YP_001850767.1 2983451 D 216594 CDS YP_001850768.1 183982477 6226729 2984576..2985790 1 NC_010612.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 2985790 argJ 6226729 argJ Mycobacterium marinum M bifunctional ornithine acetyltransferase/N-acetylglutamate synthase YP_001850768.1 2984576 D 216594 CDS YP_001850769.1 183982478 6226730 2985787..2986668 1 NC_010612.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 2986668 argB 6226730 argB Mycobacterium marinum M acetylglutamate kinase YP_001850769.1 2985787 D 216594 CDS YP_001850770.1 183982479 6226731 2986665..2987855 1 NC_010612.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 2987855 argD 6226731 argD Mycobacterium marinum M acetylornithine aminotransferase YP_001850770.1 2986665 D 216594 CDS YP_001850771.1 183982480 6226732 2987852..2988778 1 NC_010612.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 2988778 argF 6226732 argF Mycobacterium marinum M ornithine carbamoyltransferase YP_001850771.1 2987852 D 216594 CDS YP_001850772.1 183982481 6226733 2988775..2989275 1 NC_010612.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 2989275 argR 6226733 argR Mycobacterium marinum M arginine repressor YP_001850772.1 2988775 D 216594 CDS YP_001850773.1 183982482 6226734 2989324..2990520 1 NC_010612.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 2990520 argG 6226734 argG Mycobacterium marinum M argininosuccinate synthase YP_001850773.1 2989324 D 216594 CDS YP_001850774.1 183982483 6226735 2990630..2992042 1 NC_010612.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 2992042 argH 6226735 argH Mycobacterium marinum M argininosuccinate lyase YP_001850774.1 2990630 D 216594 CDS YP_001850775.1 183982484 6226736 2992146..2993207 1 NC_010612.1 possibly involved in the biosynthesis of secondary metabolites [catalytic activity: 3 malonyl-CoA + 4- coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2]; chalcone synthase, Pks10 2993207 pks10 6226736 pks10 Mycobacterium marinum M chalcone synthase, Pks10 YP_001850775.1 2992146 D 216594 CDS YP_001850776.1 183982485 6226737 2993342..2999704 1 NC_010612.1 Has some homology to Pks12 required for mycoketide syntehsis; polyketide synthase Pks7 2999704 pks7 6226737 pks7 Mycobacterium marinum M polyketide synthase Pks7 YP_001850776.1 2993342 D 216594 CDS YP_001850777.1 183982486 6226738 2999725..3006069 1 NC_010612.1 function unknown. contains acyl transferase, dehydratase, ketoreductase, and phosphopantetheine attachment site; polyketide synthase 3006069 pks8 6226738 pks8 Mycobacterium marinum M polyketide synthase YP_001850777.1 2999725 D 216594 CDS YP_001850778.1 183982487 6226739 3006075..3009164 1 NC_010612.1 polyketide synthase Pks9 3009164 pks9 6226739 pks9 Mycobacterium marinum M polyketide synthase Pks9 YP_001850778.1 3006075 D 216594 CDS YP_001850779.1 183982488 6226740 3009319..3010380 1 NC_010612.1 possibly involved in the biosynthesis of secondary metabolites [catalytic activity: 3 malonyl-CoA + 4- coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2]; chalcone synthase, Pks11 3010380 pks11_1 6226740 pks11_1 Mycobacterium marinum M chalcone synthase, Pks11 YP_001850779.1 3009319 D 216594 CDS YP_001850780.1 183982489 6226741 complement(3010363..3011664) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 139A3 Cyp139A3 3011664 cyp139A3 6226741 cyp139A3 Mycobacterium marinum M cytochrome P450 139A3 Cyp139A3 YP_001850780.1 3010363 R 216594 CDS YP_001850781.1 183982490 6226742 complement(3011661..3013430) 1 NC_010612.1 thought to be involved in active transport of macrolide across the membrane (export). macrolide antibiotics resistance by an export mechanism. responsible for energy coupling to the transport system; ABC transporter ATP-binding protein 3013430 6226742 MMAR_2476 Mycobacterium marinum M ABC transporter ATP-binding protein YP_001850781.1 3011661 R 216594 CDS YP_001850782.1 183982491 6226743 3014471..3015583 1 NC_010612.1 wide specificity for D-amino acids. also acts on glycine [catalytic activity: a D-amino acid + H2O + O2 = a 2-OXO acid + NH3 + H2O2]; D-amino acid oxidase Aao 3015583 aao_1 6226743 aao_1 Mycobacterium marinum M D-amino acid oxidase Aao YP_001850782.1 3014471 D 216594 CDS YP_001850783.1 183982492 6226744 3015733..3018714 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3018714 6226744 MMAR_2478 Mycobacterium marinum M acyl-CoA synthetase YP_001850783.1 3015733 D 216594 CDS YP_001850784.1 183982493 6226745 3018707..3018940 1 NC_010612.1 hypothetical protein 3018940 6226745 MMAR_2479 Mycobacterium marinum M hypothetical protein YP_001850784.1 3018707 D 216594 CDS YP_001850785.1 183982494 6226746 3019050..3019487 1 NC_010612.1 role in amino acid transport and metabolism; lactoylglutathione lyase, GloA 3019487 gloA 6226746 gloA Mycobacterium marinum M lactoylglutathione lyase, GloA YP_001850785.1 3019050 D 216594 CDS YP_001850786.1 183982495 6226747 complement(3019673..3021718) 1 NC_010612.1 PE-PGRS family protein 3021718 6226747 MMAR_2481 Mycobacterium marinum M PE-PGRS family protein YP_001850786.1 3019673 R 216594 CDS YP_001850787.1 183982496 6226748 complement(3022114..3022737) 1 NC_010612.1 hypothetical protein 3022737 6226748 MMAR_2482 Mycobacterium marinum M hypothetical protein YP_001850787.1 3022114 R 216594 CDS YP_001850788.1 183982497 6226749 complement(3022739..3022981) 1 NC_010612.1 thought to be involved in active transport of undeterminated substrate (possibly drug) across the membrane. responsible for the translocation of the substrate across the membrane; antibiotic resistance ABC transporter efflux protein 3022981 6226749 MMAR_2483 Mycobacterium marinum M antibiotic resistance ABC transporter efflux protein YP_001850788.1 3022739 R 216594 CDS YP_001850789.1 183982498 6226750 complement(3023649..3024272) 1 NC_010612.1 hypothetical protein 3024272 6226750 MMAR_2484 Mycobacterium marinum M hypothetical protein YP_001850789.1 3023649 R 216594 CDS YP_001850790.1 183982499 6226751 complement(3024274..3024954) 1 NC_010612.1 thought to be involved in active transport of undeterminated substrate (possibly drug) across the membrane. responsible for the translocation of the substrate across the membrane; antibiotic resistance ABC transporter efflux protein 3024954 6226751 MMAR_2485 Mycobacterium marinum M antibiotic resistance ABC transporter efflux protein YP_001850790.1 3024274 R 216594 CDS YP_001850791.1 183982500 6226752 complement(3025026..3025790) 1 NC_010612.1 thought to be involved in active transport of undeterminated substrate (possibly drug) across the membrane. responsible for energy coupling to the transport system; antibiotic resistance ABC transporter efflux system, ATP-binding protein 3025790 6226752 MMAR_2486 Mycobacterium marinum M antibiotic resistance ABC transporter efflux system, ATP-binding protein YP_001850791.1 3025026 R 216594 CDS YP_001850792.1 183982501 6226753 3025853..3026464 1 NC_010612.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase 3026464 mpg 6226753 mpg Mycobacterium marinum M 3-methyladenine DNA glycosylase YP_001850792.1 3025853 D 216594 CDS YP_001850793.1 183982502 6226754 3026476..3027768 1 NC_010612.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 3027768 tyrS 6226754 tyrS Mycobacterium marinum M tyrosyl-tRNA synthetase YP_001850793.1 3026476 D 216594 CDS YP_001850794.1 183982503 6226755 3028074..3028364 1 NC_010612.1 hypothetical protein 3028364 6226755 MMAR_5562 Mycobacterium marinum M hypothetical protein YP_001850794.1 3028074 D 216594 CDS YP_001850795.1 183982504 6226756 complement(3028598..3029569) 1 NC_010612.1 transposition of ISMyma06; transposase for ISMyma06 3029569 6226756 MMAR_2489 Mycobacterium marinum M transposase for ISMyma06 YP_001850795.1 3028598 R 216594 CDS YP_001850796.1 183982505 6226757 complement(3029692..3031554) 1 NC_010612.1 PE-PGRS family protein 3031554 6226757 MMAR_2490 Mycobacterium marinum M PE-PGRS family protein YP_001850796.1 3029692 R 216594 CDS YP_001850797.1 183982506 6226758 complement(3031896..3033830) 1 NC_010612.1 hypothetical protein 3033830 6226758 MMAR_2491 Mycobacterium marinum M hypothetical protein YP_001850797.1 3031896 R 216594 CDS YP_001850798.1 183982507 6226759 complement(3034269..3036182) 1 NC_010612.1 PE-PGRS family protein 3036182 6226759 MMAR_2492 Mycobacterium marinum M PE-PGRS family protein YP_001850798.1 3034269 R 216594 CDS YP_001850799.1 183982508 6226760 complement(3036358..3037869) 1 NC_010612.1 hypothetical protein 3037869 6226760 MMAR_2493 Mycobacterium marinum M hypothetical protein YP_001850799.1 3036358 R 216594 CDS YP_001850800.1 183982509 6226761 complement(3037866..3039128) 1 NC_010612.1 function unknown; hypothetical protein 3039128 6226761 MMAR_2494 Mycobacterium marinum M hypothetical protein YP_001850800.1 3037866 R 216594 CDS YP_001850801.1 183982510 6226762 3039688..3040077 1 NC_010612.1 lipoprotein LprJ 3040077 lprJ 6226762 lprJ Mycobacterium marinum M lipoprotein LprJ YP_001850801.1 3039688 D 216594 CDS YP_001850802.1 183982511 6226763 3040138..3040971 1 NC_010612.1 hypothetical protein 3040971 6226763 MMAR_2496 Mycobacterium marinum M hypothetical protein YP_001850802.1 3040138 D 216594 CDS YP_001850803.1 183982512 6226764 3040974..3041984 1 NC_010612.1 function unknown; probably involved in cellular metabolism; phosphatase 3041984 6226764 MMAR_2497 Mycobacterium marinum M phosphatase YP_001850803.1 3040974 D 216594 CDS YP_001850804.1 183982513 6226765 3042009..3042185 1 NC_010612.1 hypothetical protein 3042185 6226765 MMAR_2498 Mycobacterium marinum M hypothetical protein YP_001850804.1 3042009 D 216594 CDS YP_001850805.1 183982514 6226766 3042193..3043038 1 NC_010612.1 has a contact-dependent haemolytic activity; possibly involved in virulence (pore formation); cytotoxin/hemolysin, TlyA 3043038 tlyA 6226766 tlyA Mycobacterium marinum M cytotoxin/hemolysin, TlyA YP_001850805.1 3042193 D 216594 CDS YP_001850806.1 183982515 6226767 3043035..3043958 1 NC_010612.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 3043958 ppnK 6226767 ppnK Mycobacterium marinum M inorganic polyphosphate/ATP-NAD kinase YP_001850806.1 3043035 D 216594 CDS YP_001850807.1 183982516 6226768 3043971..3045716 1 NC_010612.1 involved in recombinational repair of damaged DNA; DNA repair protein RecN 3045716 recN 6226768 recN Mycobacterium marinum M DNA repair protein RecN YP_001850807.1 3043971 D 216594 CDS YP_001850808.1 183982517 6226769 3045882..3047063 1 NC_010612.1 hypothetical protein 3047063 6226769 MMAR_2502 Mycobacterium marinum M hypothetical protein YP_001850808.1 3045882 D 216594 CDS YP_001850809.1 183982518 6226770 3047085..3048038 1 NC_010612.1 hypothetical protein 3048038 6226770 MMAR_2503 Mycobacterium marinum M hypothetical protein YP_001850809.1 3047085 D 216594 CDS YP_001850810.1 183982519 6226771 3048176..3049927 1 NC_010612.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 3049927 pyrG 6226771 pyrG Mycobacterium marinum M CTP synthetase YP_001850810.1 3048176 D 216594 CDS YP_001850811.1 183982520 6226772 3049920..3050543 1 NC_010612.1 NUDIX hydrolases catalyze the hydrolysis of a variety of nucleoside diphosphate derivatives; NUDIX hydrolase 3050543 6226772 MMAR_2505 Mycobacterium marinum M NUDIX hydrolase YP_001850811.1 3049920 D 216594 CDS YP_001850812.1 183982521 6226773 3050540..3051481 1 NC_010612.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 3051481 xerD 6226773 xerD Mycobacterium marinum M site-specific tyrosine recombinase XerD YP_001850812.1 3050540 D 216594 CDS YP_001850813.1 183982522 6226774 complement(3051488..3052240) 1 NC_010612.1 catalyzes the O-methylation [catalytic activity: S- adenosyl-L-methionine + catechol = S-adenosyl-L- homocysteine + guaiacol]; O-methyltransferase 3052240 6226774 MMAR_2507 Mycobacterium marinum M O-methyltransferase YP_001850813.1 3051488 R 216594 CDS YP_001850814.1 183982523 6226775 3052400..3053626 1 NC_010612.1 this is a family of myo-inositol-1-phosphate synthases. inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated to inositol. inositol phosphates play an important role in signal transduction; myo-inositol-1-phosphate synthase 3053626 6226775 MMAR_2508 Mycobacterium marinum M myo-inositol-1-phosphate synthase YP_001850814.1 3052400 D 216594 CDS YP_001850815.1 183982524 6226776 3053623..3054486 1 NC_010612.1 membrane associated. contains Cdd matches to polyprenyltransferase domains; transferase 3054486 6226776 MMAR_2509 Mycobacterium marinum M transferase YP_001850815.1 3053623 D 216594 CDS YP_001850816.1 183982525 6226777 3054486..3055907 1 NC_010612.1 contains Cdd COG1082,sugar phosphate isomerases/epimerases [carbohydrate transport and metabolism; sugar phosphate isomerase/epimerase 3055907 6226777 MMAR_2510 Mycobacterium marinum M sugar phosphate isomerase/epimerase YP_001850816.1 3054486 D 216594 CDS YP_001850817.1 183982526 6226778 3055904..3056755 1 NC_010612.1 contains Cdd COG1099, predicted metal-dependent hydrolases with the TIM-barrel FolD; metal dependent hydrolase 3056755 6226778 MMAR_2511 Mycobacterium marinum M metal dependent hydrolase YP_001850817.1 3055904 D 216594 CDS YP_001850818.1 183982527 6226779 3056752..3057873 1 NC_010612.1 function unknown; closest homologue NP_627450.1 hypothetical (41%ID over 169aa, expect = 3e-24) protein streptomyces coelicolor A3(2) (C-terminal); hypothetical protein 3057873 6226779 MMAR_2512 Mycobacterium marinum M hypothetical protein YP_001850818.1 3056752 D 216594 CDS YP_001850819.1 183982528 6226780 3057870..3059249 1 NC_010612.1 function unknown; hypothetical protein 3059249 6226780 MMAR_2513 Mycobacterium marinum M hypothetical protein YP_001850819.1 3057870 D 216594 CDS YP_001850820.1 183982529 6226781 3059350..3060366 1 NC_010612.1 hypothetical protein 3060366 6226781 MMAR_2514 Mycobacterium marinum M hypothetical protein YP_001850820.1 3059350 D 216594 CDS YP_001850821.1 183982530 6226782 complement(3060387..3061976) 1 NC_010612.1 translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; integral membrane drug efflux protein 3061976 6226782 MMAR_2515 Mycobacterium marinum M integral membrane drug efflux protein YP_001850821.1 3060387 R 216594 CDS YP_001850822.1 183982531 6226783 complement(3062118..3063296) 1 NC_010612.1 PPE family protein 3063296 6226783 MMAR_2516 Mycobacterium marinum M PPE family protein YP_001850822.1 3062118 R 216594 CDS YP_001850823.1 183982532 6226784 complement(3063528..3064841) 1 NC_010612.1 PPE family protein 3064841 6226784 MMAR_2517 Mycobacterium marinum M PPE family protein YP_001850823.1 3063528 R 216594 CDS YP_001850824.1 183982533 6226785 complement(3065269..3073692) 1 NC_010612.1 production of unknown metabolite - contains two modules of: C, a (Phe) , T, E and C, a (arg),T, int te; non-ribosomal peptide synthetase 3073692 6226785 MMAR_2518 Mycobacterium marinum M non-ribosomal peptide synthetase YP_001850824.1 3065269 R 216594 CDS YP_001850825.1 183982534 6226786 complement(3073741..3073971) 1 NC_010612.1 thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins; protein MbtH_2 3073971 mbtH_2 6226786 mbtH_2 Mycobacterium marinum M protein MbtH_2 YP_001850825.1 3073741 R 216594 CDS YP_001850826.1 183982535 6226787 complement(3073992..3075215) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 3075215 6226787 MMAR_2520 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001850826.1 3073992 R 216594 CDS YP_001850827.1 183982536 6226788 complement(3075222..3075644) 1 NC_010612.1 hypothetical protein 3075644 6226788 MMAR_2521 Mycobacterium marinum M hypothetical protein YP_001850827.1 3075222 R 216594 CDS YP_001850828.1 183982537 6226789 3076470..3077132 1 NC_010612.1 hypothetical protein 3077132 6226789 MMAR_2522 Mycobacterium marinum M hypothetical protein YP_001850828.1 3076470 D 216594 CDS YP_001850829.1 183982538 6226790 3077213..3078169 1 NC_010612.1 function unknown, possible role in chromosome partioning; Soj family ATPase 3078169 6226790 MMAR_2523 Mycobacterium marinum M Soj family ATPase YP_001850829.1 3077213 D 216594 CDS YP_001850830.1 183982539 6226791 3078166..3078993 1 NC_010612.1 hypothetical protein 3078993 6226791 MMAR_2524 Mycobacterium marinum M hypothetical protein YP_001850830.1 3078166 D 216594 CDS YP_001850831.1 183982540 6226792 3078993..3079700 1 NC_010612.1 transcriptional regulator 3079700 6226792 MMAR_2525 Mycobacterium marinum M transcriptional regulator YP_001850831.1 3078993 D 216594 CDS YP_001850832.1 183982541 6226793 3079700..3080461 1 NC_010612.1 possible role in ribosome biogenesis and protein translation; pseudouridylate synthase 3080461 6226793 MMAR_2526 Mycobacterium marinum M pseudouridylate synthase YP_001850832.1 3079700 D 216594 CDS YP_001850833.1 183982542 6226794 3080502..3081260 1 NC_010612.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 3081260 cmk 6226794 cmk Mycobacterium marinum M cytidylate kinase YP_001850833.1 3080502 D 216594 CDS YP_001850834.1 183982543 6226795 3081257..3082666 1 NC_010612.1 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 3082666 engA 6226795 engA Mycobacterium marinum M GTP-binding protein EngA YP_001850834.1 3081257 D 216594 CDS YP_001850835.1 183982544 6226799 3084593..3084916 1 NC_010612.1 transposition of ISMyma03; transposase, ISMyma03_aa1 3084916 6226799 MMAR_2531 Mycobacterium marinum M transposase, ISMyma03_aa1 YP_001850835.1 3084593 D 216594 CDS YP_001850836.1 183982545 6226800 3085003..3085866 1 NC_010612.1 transposition of ISMyma03; transposase, ISMyma03_aa2 3085866 6226800 MMAR_2532 Mycobacterium marinum M transposase, ISMyma03_aa2 YP_001850836.1 3085003 D 216594 CDS YP_001850837.1 183982546 6226801 3086295..3086723 1 NC_010612.1 hypothetical protein 3086723 6226801 MMAR_2533 Mycobacterium marinum M hypothetical protein YP_001850837.1 3086295 D 216594 CDS YP_001850838.1 183982547 6226802 complement(3086939..3088153) 1 NC_010612.1 function unknown. possibly a protective antigen involved with the early control of infection; PPE family protein 3088153 6226802 MMAR_2534 Mycobacterium marinum M PPE family protein YP_001850838.1 3086939 R 216594 CDS YP_001850839.1 183982548 6226803 complement(3088681..3089301) 1 NC_010612.1 hypothetical protein 3089301 6226803 MMAR_2535 Mycobacterium marinum M hypothetical protein YP_001850839.1 3088681 R 216594 CDS YP_001850840.1 183982549 6226804 complement(3089369..3091663) 1 NC_010612.1 metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)]; metal cation transporter p-type ATPase 3091663 6226804 MMAR_2536 Mycobacterium marinum M metal cation transporter p-type ATPase YP_001850840.1 3089369 R 216594 CDS YP_001850841.1 183982550 6226805 complement(3091725..3092030) 1 NC_010612.1 hypothetical protein 3092030 6226805 MMAR_2537 Mycobacterium marinum M hypothetical protein YP_001850841.1 3091725 R 216594 CDS YP_001850842.1 183982551 6226806 complement(3092090..3092698) 1 NC_010612.1 hypothetical protein 3092698 6226806 MMAR_2538 Mycobacterium marinum M hypothetical protein YP_001850842.1 3092090 R 216594 CDS YP_001850843.1 183982552 6226807 3092729..3093754 1 NC_010612.1 function unknown, contains six NHL repeats. the NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. it is about 40 residues long and resembles the wd repeat pfam00400. the repeats may have a catalytic activity, proteolysis of one menber has shown that the peptidyl-alpha-hydroxyglycine alpha-amidating lyase (pal) activity is localised to the repeats. one member interacts with the activation domain of tat. this interaction is mediated by the NHL repeats; hypothetical protein 3093754 6226807 MMAR_2539 Mycobacterium marinum M hypothetical protein YP_001850843.1 3092729 D 216594 CDS YP_001850844.1 183982553 6226809 3094179..3094943 1 NC_010612.1 hypothetical protein 3094943 6226809 MMAR_2541 Mycobacterium marinum M hypothetical protein YP_001850844.1 3094179 D 216594 CDS YP_001850845.1 183982554 6226810 complement(3094924..3095475) 1 NC_010612.1 hypothetical protein 3095475 6226810 MMAR_2542 Mycobacterium marinum M hypothetical protein YP_001850845.1 3094924 R 216594 CDS YP_001850846.1 183982555 6226811 3095940..3097043 1 NC_010612.1 hypothetical protein 3097043 6226811 MMAR_2543 Mycobacterium marinum M hypothetical protein YP_001850846.1 3095940 D 216594 CDS YP_001850847.1 183982556 6226813 3097429..3097827 1 NC_010612.1 hypothetical protein 3097827 6226813 MMAR_2545 Mycobacterium marinum M hypothetical protein YP_001850847.1 3097429 D 216594 CDS YP_001850848.1 183982557 6226814 complement(3097923..3098735) 1 NC_010612.1 function unknown; domain identity to carbonic anhydrases. these are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide; hypothetical protein 3098735 6226814 MMAR_2546 Mycobacterium marinum M hypothetical protein YP_001850848.1 3097923 R 216594 CDS YP_001850849.1 183982558 6226815 3098734..3099057 1 NC_010612.1 transposition of ISMyma03; transposase, ISMyma03_aa1 3099057 6226815 MMAR_2547 Mycobacterium marinum M transposase, ISMyma03_aa1 YP_001850849.1 3098734 D 216594 CDS YP_001850850.1 183982559 6226816 3099144..3100007 1 NC_010612.1 transposition of ISMyma03; transposase, ISMyma03_aa2 3100007 6226816 MMAR_2548 Mycobacterium marinum M transposase, ISMyma03_aa2 YP_001850850.1 3099144 D 216594 CDS YP_001850851.1 183982560 6226817 3100047..3100499 1 NC_010612.1 hypothetical protein 3100499 6226817 MMAR_2549 Mycobacterium marinum M hypothetical protein YP_001850851.1 3100047 D 216594 CDS YP_001850852.1 183982561 6226818 3100804..3102099 1 NC_010612.1 transmembrane protein 3102099 6226818 MMAR_2550 Mycobacterium marinum M transmembrane protein YP_001850852.1 3100804 D 216594 CDS YP_001850853.1 183982562 6226819 3102387..3104339 1 NC_010612.1 PE-PGRS family protein 3104339 6226819 MMAR_2551 Mycobacterium marinum M PE-PGRS family protein YP_001850853.1 3102387 D 216594 CDS YP_001850854.1 183982563 6226820 complement(3104422..3105213) 1 NC_010612.1 this CDS encodes a 3-oxo-5-alpha-steroid 4- dehydrogenase. this family consists of 3-oxo-5-alpha- steroid 4-dehydrogenases. also known as steroid 5-alpha- reductase, the reaction catalysed by this enzyme is: 3-oxo- 5-alpha-steroid + acceptor <=> 3; hypothetical protein 3105213 6226820 MMAR_2552 Mycobacterium marinum M hypothetical protein YP_001850854.1 3104422 R 216594 CDS YP_001850855.1 183982564 6226821 complement(3105433..3105702) 1 NC_010612.1 hypothetical protein 3105702 6226821 MMAR_2553 Mycobacterium marinum M hypothetical protein YP_001850855.1 3105433 R 216594 CDS YP_001850856.1 183982565 6226822 complement(3105762..3106097) 1 NC_010612.1 hypothetical protein 3106097 6226822 MMAR_2554 Mycobacterium marinum M hypothetical protein YP_001850856.1 3105762 R 216594 CDS YP_001850857.1 183982566 6226823 complement(3106285..3106929) 1 NC_010612.1 hypothetical protein 3106929 6226823 MMAR_2555 Mycobacterium marinum M hypothetical protein YP_001850857.1 3106285 R 216594 CDS YP_001850858.1 183982567 6226825 3107269..3108420 1 NC_010612.1 function unknown role in carbohydrate transport and metabolism; aldose 1-epimerase 3108420 6226825 MMAR_2557 Mycobacterium marinum M aldose 1-epimerase YP_001850858.1 3107269 D 216594 CDS YP_001850859.1 183982568 6226826 complement(3108381..3109187) 1 NC_010612.1 hypothetical protein 3109187 6226826 MMAR_2558 Mycobacterium marinum M hypothetical protein YP_001850859.1 3108381 R 216594 CDS YP_001850860.1 183982569 6226827 complement(3109248..3110270) 1 NC_010612.1 oxidoreductase 3110270 6226827 MMAR_2559 Mycobacterium marinum M oxidoreductase YP_001850860.1 3109248 R 216594 CDS YP_001850861.1 183982570 6226828 complement(3110279..3111091) 1 NC_010612.1 involved in transcriptional mechanism; GntR family transcriptional regulator 3111091 6226828 MMAR_2560 Mycobacterium marinum M GntR family transcriptional regulator YP_001850861.1 3110279 R 216594 CDS YP_001850862.1 183982571 6226829 3111267..3111593 1 NC_010612.1 hypothetical protein 3111593 6226829 MMAR_2561 Mycobacterium marinum M hypothetical protein YP_001850862.1 3111267 D 216594 CDS YP_001850863.1 183982572 6226830 complement(3111583..3112524) 1 NC_010612.1 hypothetical protein 3112524 6226830 MMAR_2562 Mycobacterium marinum M hypothetical protein YP_001850863.1 3111583 R 216594 CDS YP_001850864.1 183982573 6226831 complement(3112579..3112974) 1 NC_010612.1 function unknown but may be involved in inhibition of protein synthesis by cleavage of mRNA; translation initiation inhibitor 3112974 6226831 MMAR_2563 Mycobacterium marinum M translation initiation inhibitor YP_001850864.1 3112579 R 216594 CDS YP_001850865.1 183982574 6226832 3113519..3114505 1 NC_010612.1 involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of; polyprenyl synthetase IdsB 3114505 idsB 6226832 idsB Mycobacterium marinum M polyprenyl synthetase IdsB YP_001850865.1 3113519 D 216594 CDS YP_001850866.1 183982575 6226833 3114505..3115860 1 NC_010612.1 hypothetical protein 3115860 6226833 MMAR_2565 Mycobacterium marinum M hypothetical protein YP_001850866.1 3114505 D 216594 CDS YP_001850867.1 183982576 6226834 complement(3115902..3116774) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hydrolase 3116774 6226834 MMAR_2566 Mycobacterium marinum M hydrolase YP_001850867.1 3115902 R 216594 CDS YP_001850868.1 183982577 6226835 3116960..3117268 1 NC_010612.1 hypothetical protein 3117268 6226835 MMAR_2567 Mycobacterium marinum M hypothetical protein YP_001850868.1 3116960 D 216594 CDS YP_001850869.1 183982578 6226836 complement(3117473..3119989) 1 NC_010612.1 the members of this family catalyse the formation of glucose 1-phosphate from one of the following polyglucoses; glycogen, starch, glucan or maltodextrin; carbohydrate phosphorylase 3119989 6226836 MMAR_2568 Mycobacterium marinum M carbohydrate phosphorylase YP_001850869.1 3117473 R 216594 CDS YP_001850870.1 183982579 6226837 complement(3120125..3120802) 1 NC_010612.1 function unknown but contains signal peptide; hypothetical protein 3120802 6226837 MMAR_2569 Mycobacterium marinum M hypothetical protein YP_001850870.1 3120125 R 216594 CDS YP_001850871.1 183982580 6226838 3121055..3122041 1 NC_010612.1 function unknown but domain identity with penicillin V acylase and related amidases; hydrolase/amidase 3122041 6226838 MMAR_2570 Mycobacterium marinum M hydrolase/amidase YP_001850871.1 3121055 D 216594 CDS YP_001850872.1 183982581 6226839 3122210..3123766 1 NC_010612.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinate-semialdehyde dehydrogenase 3123766 gabD2 6226839 gabD2 Mycobacterium marinum M succinate-semialdehyde dehydrogenase YP_001850872.1 3122210 D 216594 CDS YP_001850873.1 183982582 6226840 complement(3123770..3124957) 1 NC_010612.1 function unknown but contains signal peptide and domain identity with periplasmic component of the tol biopolymer transport system; hypothetical protein 3124957 6226840 MMAR_2572 Mycobacterium marinum M hypothetical protein YP_001850873.1 3123770 R 216594 CDS YP_001850874.1 183982583 6226841 complement(3125259..3126119) 1 NC_010612.1 hypothetical protein 3126119 6226841 MMAR_2573 Mycobacterium marinum M hypothetical protein YP_001850874.1 3125259 R 216594 CDS YP_001850875.1 183982584 6226842 3126382..3127893 1 NC_010612.1 involved in active transport of unknown sugars across the membrane. responsible for the translocation of the substrate across the membrane; sugar transporter 3127893 6226842 MMAR_2574 Mycobacterium marinum M sugar transporter YP_001850875.1 3126382 D 216594 CDS YP_001850876.1 183982585 6226843 3128024..3129445 1 NC_010612.1 function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages; PE-PGRS family protein 3129445 6226843 MMAR_2575 Mycobacterium marinum M PE-PGRS family protein YP_001850876.1 3128024 D 216594 CDS YP_001850877.1 183982586 6226844 complement(3129490..3132819) 1 NC_010612.1 involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase transcriptional regulatory protein PknK 3132819 pknK 6226844 pknK Mycobacterium marinum M serine/threonine-protein kinase transcriptional regulatory protein PknK YP_001850877.1 3129490 R 216594 CDS YP_001850878.1 183982587 6226845 complement(3132920..3133291) 1 NC_010612.1 hypothetical protein 3133291 6226845 MMAR_2577 Mycobacterium marinum M hypothetical protein YP_001850878.1 3132920 R 216594 CDS YP_001850879.1 183982588 6226846 3133636..3136092 1 NC_010612.1 metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation transporter p-type ATPase a, CtpF 3136092 6226846 MMAR_2578 Mycobacterium marinum M metal cation transporter p-type ATPase a, CtpF YP_001850879.1 3133636 D 216594 CDS YP_001850880.1 183982589 6226847 3136089..3137456 1 NC_010612.1 thought to be involved in transport amino acids across the membrane; amino acid transporter PotE 3137456 potE 6226847 potE Mycobacterium marinum M amino acid transporter PotE YP_001850880.1 3136089 D 216594 CDS YP_001850881.1 183982590 6226848 3137549..3138286 1 NC_010612.1 hypothetical protein 3138286 6226848 MMAR_2580 Mycobacterium marinum M hypothetical protein YP_001850881.1 3137549 D 216594 CDS YP_001850882.1 183982591 6226849 3138515..3140341 1 NC_010612.1 involved in signal transduction (via phosphorylation). thought to be involved in membrane transport [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 3140341 pknE 6226849 pknE Mycobacterium marinum M Ser/Thr protein kinase YP_001850882.1 3138515 D 216594 CDS YP_001850883.1 183982592 6226850 3140411..3141766 1 NC_010612.1 hypothetical protein 3141766 6226850 MMAR_2582 Mycobacterium marinum M hypothetical protein YP_001850883.1 3140411 D 216594 CDS YP_001850884.1 183982593 6226851 complement(3141776..3143272) 1 NC_010612.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 3143272 6226851 MMAR_2583 Mycobacterium marinum M potassium/proton antiporter YP_001850884.1 3141776 R 216594 CDS YP_001850885.1 183982594 6226852 3143519..3144241 1 NC_010612.1 part of a potassium transport system; TRK system potassium uptake protein CeoC1 3144241 ceoC1 6226852 ceoC1 Mycobacterium marinum M TRK system potassium uptake protein CeoC1 YP_001850885.1 3143519 D 216594 CDS YP_001850886.1 183982595 6226853 3144311..3146674 1 NC_010612.1 function unknown but may play a role in protein translation; transcriptional accessory protein Tex 3146674 tex 6226853 tex Mycobacterium marinum M transcriptional accessory protein Tex YP_001850886.1 3144311 D 216594 CDS YP_001850887.1 183982596 6226854 3146890..3148359 1 NC_010612.1 function unknown but contains signal peptide; hypothetical protein 3148359 6226854 MMAR_2586 Mycobacterium marinum M hypothetical protein YP_001850887.1 3146890 D 216594 CDS YP_001850888.1 183982597 6226855 complement(3148368..3149492) 1 NC_010612.1 transfer of electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation; NADH dehydrogenase Ndh1 3149492 ndh1 6226855 ndh1 Mycobacterium marinum M NADH dehydrogenase Ndh1 YP_001850888.1 3148368 R 216594 CDS YP_001850889.1 183982598 6226856 complement(3149489..3150376) 1 NC_010612.1 hypothetical protein 3150376 6226856 MMAR_2588 Mycobacterium marinum M hypothetical protein YP_001850889.1 3149489 R 216594 CDS YP_001850890.1 183982599 6226857 complement(3150640..3151332) 1 NC_010612.1 involved in the synthesis of decaprenyl diphosphate, a molecule which has a central role in the biosynthesis of most features of the mycobacterial cell wall. adds seven more isoprene units to omega,E, Z- farnesyl diphosphate and releases decaprenyl diphosphate; Z-decaprenyl diphosphate synthase 3151332 6226857 MMAR_2589 Mycobacterium marinum M Z-decaprenyl diphosphate synthase YP_001850890.1 3150640 R 216594 CDS YP_001850891.1 183982600 6226858 complement(3151815..3152681) 1 NC_010612.1 hypothetical protein 3152681 6226858 MMAR_2590 Mycobacterium marinum M hypothetical protein YP_001850891.1 3151815 R 216594 CDS YP_001850892.1 183982601 6226859 3153310..3159585 1 NC_010612.1 PPE family protein 3159585 6226859 MMAR_2591 Mycobacterium marinum M PPE family protein YP_001850892.1 3153310 D 216594 CDS YP_001850893.1 183982602 6226860 complement(3159606..3160442) 1 NC_010612.1 short chain dehydrogenase 3160442 6226860 MMAR_2592 Mycobacterium marinum M short chain dehydrogenase YP_001850893.1 3159606 R 216594 CDS YP_001850894.1 183982603 6226861 3160614..3161909 1 NC_010612.1 H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane; divalent cation-transport integral membrane protein 3161909 6226861 MMAR_2593 Mycobacterium marinum M divalent cation-transport integral membrane protein YP_001850894.1 3160614 D 216594 CDS YP_001850895.1 183982604 6226862 complement(3161925..3162683) 1 NC_010612.1 hypothetical protein 3162683 6226862 MMAR_2594 Mycobacterium marinum M hypothetical protein YP_001850895.1 3161925 R 216594 CDS YP_001850896.1 183982605 6226863 complement(3162734..3163861) 1 NC_010612.1 hypothetical protein 3163861 6226863 MMAR_2595 Mycobacterium marinum M hypothetical protein YP_001850896.1 3162734 R 216594 CDS YP_001850897.1 183982606 6226864 3164212..3165732 1 NC_010612.1 PE-PGRS family protein 3165732 6226864 MMAR_2596 Mycobacterium marinum M PE-PGRS family protein YP_001850897.1 3164212 D 216594 CDS YP_001850898.1 183982607 6226865 complement(3165755..3167263) 1 NC_010612.1 function unknown, but involved in lipid degradation; fatty-acid-CoA ligase FadD13 3167263 fadD13 6226865 fadD13 Mycobacterium marinum M fatty-acid-CoA ligase FadD13 YP_001850898.1 3165755 R 216594 CDS YP_001850899.1 183982608 6226866 complement(3167302..3168720) 1 NC_010612.1 hypothetical protein 3168720 6226866 MMAR_2598 Mycobacterium marinum M hypothetical protein YP_001850899.1 3167302 R 216594 CDS YP_001850900.1 183982609 6226867 complement(3168717..3170156) 1 NC_010612.1 hypothetical protein 3170156 6226867 MMAR_2599 Mycobacterium marinum M hypothetical protein YP_001850900.1 3168717 R 216594 CDS YP_001850901.1 183982610 6226868 complement(3170153..3171001) 1 NC_010612.1 possibly involved in detoxification reactions following oxidative damage to lipids; short-chain dehydrogenase 3171001 6226868 MMAR_2600 Mycobacterium marinum M short-chain dehydrogenase YP_001850901.1 3170153 R 216594 CDS YP_001850902.1 183982611 6226869 3171104..3172390 1 NC_010612.1 domain: regulator of polyketide synthase expression; hypothetical protein 3172390 6226869 MMAR_2601 Mycobacterium marinum M hypothetical protein YP_001850902.1 3171104 D 216594 CDS YP_001850903.1 183982612 6226870 3172514..3172981 1 NC_010612.1 hypothetical protein 3172981 6226870 MMAR_2602 Mycobacterium marinum M hypothetical protein YP_001850903.1 3172514 D 216594 CDS YP_001850904.1 183982613 6226871 3172985..3173368 1 NC_010612.1 hypothetical protein 3173368 6226871 MMAR_2603 Mycobacterium marinum M hypothetical protein YP_001850904.1 3172985 D 216594 CDS YP_001850905.1 183982614 6226872 3173588..3175048 1 NC_010612.1 involved in transport of unknown substrate across the membrane; hypothetical protein 3175048 6226872 MMAR_2604 Mycobacterium marinum M hypothetical protein YP_001850905.1 3173588 D 216594 CDS YP_001850906.1 183982615 6226873 3175058..3177280 1 NC_010612.1 function unknown; probably involved in cellular metabolism; anaerobic dehydrogenase 3177280 6226873 MMAR_2605 Mycobacterium marinum M anaerobic dehydrogenase YP_001850906.1 3175058 D 216594 CDS YP_001850907.1 183982616 6226874 3177417..3178847 1 NC_010612.1 involved in signal transduction (via phosphorylation). thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr-protein kinase 3178847 pknF_3 6226874 pknF_3 Mycobacterium marinum M Ser/Thr-protein kinase YP_001850907.1 3177417 D 216594 CDS YP_001850908.1 183982617 6226875 complement(3178876..3179223) 1 NC_010612.1 hypothetical protein 3179223 6226875 MMAR_2607 Mycobacterium marinum M hypothetical protein YP_001850908.1 3178876 R 216594 CDS YP_001850909.1 183982618 6226876 3179536..3181482 1 NC_010612.1 catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine; tyramine oxidase 3181482 tynA 6226876 tynA Mycobacterium marinum M tyramine oxidase YP_001850909.1 3179536 D 216594 CDS YP_001850910.1 183982619 6226877 3181483..3183132 1 NC_010612.1 function unknown. possibly transporter involved in transport of undeterminated substrate (possibly cationic amino acids) across the membrane: so responsible for the translocation of the substrate across the membrane; hypothetical protein 3183132 6226877 MMAR_2609 Mycobacterium marinum M hypothetical protein YP_001850910.1 3181483 D 216594 CDS YP_001850911.1 183982620 6226878 3183157..3184602 1 NC_010612.1 interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]. this family of dehydrogenases act on aldehyde substrates. members use NADP as a cofactor; aldehyde dehydrogenase 3184602 6226878 MMAR_2610 Mycobacterium marinum M aldehyde dehydrogenase YP_001850911.1 3183157 D 216594 CDS YP_001850912.1 183982621 6226879 complement(3184660..3185985) 1 NC_010612.1 hypothetical protein 3185985 6226879 MMAR_2611 Mycobacterium marinum M hypothetical protein YP_001850912.1 3184660 R 216594 CDS YP_001850913.1 183982622 6226880 3186126..3188759 1 NC_010612.1 thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 3188759 6226880 MMAR_2612 Mycobacterium marinum M transmembrane ABC transporter ATP-binding protein YP_001850913.1 3186126 D 216594 CDS YP_001850914.1 183982623 6226881 complement(3188793..3189308) 1 NC_010612.1 hypothetical protein 3189308 6226881 MMAR_2613 Mycobacterium marinum M hypothetical protein YP_001850914.1 3188793 R 216594 CDS YP_001850915.1 183982624 6226882 complement(3189379..3190320) 1 NC_010612.1 function unknown but some domain identity with Zn- dependent proteases; hypothetical protein 3190320 6226882 MMAR_2614 Mycobacterium marinum M hypothetical protein YP_001850915.1 3189379 R 216594 CDS YP_001850916.1 183982625 6226883 complement(3190465..3190995) 1 NC_010612.1 acetyltransferase 3190995 6226883 MMAR_2615 Mycobacterium marinum M acetyltransferase YP_001850916.1 3190465 R 216594 CDS YP_001850917.1 183982626 6226884 3191218..3192864 1 NC_010612.1 function unknown but domain identity suggests this CDS is Acs-like, acyl-coenzyme A synthetases/AMP-(fatty) acid ligases involved in lipid metabolism; hypothetical protein 3192864 6226884 MMAR_2616 Mycobacterium marinum M hypothetical protein YP_001850917.1 3191218 D 216594 CDS YP_001850918.1 183982627 6226885 3192851..3193624 1 NC_010612.1 domain identity suggests this CDS encodes an AraD- like, ribulose-5-phosphate 4-epimerase. this enzyme and related epimerases and aldolases are involved in carbohydrate transport and metabolism; ribulose-5-phosphate 4-epimerase, AraD 3193624 araD 6226885 araD Mycobacterium marinum M ribulose-5-phosphate 4-epimerase, AraD YP_001850918.1 3192851 D 216594 CDS YP_001850919.1 183982628 6226886 3193672..3194940 1 NC_010612.1 function unknown role in cellular metabolism; amidohydrolase 3194940 6226886 MMAR_2618 Mycobacterium marinum M amidohydrolase YP_001850919.1 3193672 D 216594 CDS YP_001850920.1 183982629 6226887 3195109..3196080 1 NC_010612.1 transposase for ISMyma06 3196080 6226887 MMAR_2619 Mycobacterium marinum M transposase for ISMyma06 YP_001850920.1 3195109 D 216594 CDS YP_001850921.1 183982630 6226888 complement(3196077..3196493) 1 NC_010612.1 function unknown but domain identity suggests it may be a signal-transduction protein; hypothetical protein 3196493 6226888 MMAR_2620 Mycobacterium marinum M hypothetical protein YP_001850921.1 3196077 R 216594 CDS YP_001850922.1 183982631 6226889 3196661..3197611 1 NC_010612.1 function unknown, lipolytic enzyme probably involved in cellular metabolism; esterase/lipase 3197611 6226889 MMAR_2621 Mycobacterium marinum M esterase/lipase YP_001850922.1 3196661 D 216594 CDS YP_001850923.1 183982632 6226890 complement(3197608..3199587) 1 NC_010612.1 function unknown; involved in cellular metabolism; flavin-binding monooxygenase 3199587 6226890 MMAR_2622 Mycobacterium marinum M flavin-binding monooxygenase YP_001850923.1 3197608 R 216594 CDS YP_001850924.1 183982633 6226891 3199828..3200625 1 NC_010612.1 function unknown, probably involved in cellular metabolism; short-chain dehydrogenase 3200625 6226891 MMAR_2623 Mycobacterium marinum M short-chain dehydrogenase YP_001850924.1 3199828 D 216594 CDS YP_001850925.1 183982634 6226892 3200685..3201362 1 NC_010612.1 hypothetical protein 3201362 6226892 MMAR_2624 Mycobacterium marinum M hypothetical protein YP_001850925.1 3200685 D 216594 CDS YP_001850926.1 183982635 6226893 complement(3201387..3202979) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3202979 fadD1 6226893 fadD1 Mycobacterium marinum M acyl-CoA synthetase YP_001850926.1 3201387 R 216594 CDS YP_001850927.1 183982636 6226894 3203406..3205136 1 NC_010612.1 hypothetical protein 3205136 6226894 MMAR_2626 Mycobacterium marinum M hypothetical protein YP_001850927.1 3203406 D 216594 CDS YP_001850928.1 183982637 6226895 3205581..3206810 1 NC_010612.1 function unknown; probably involved in cellular metabolism; hypothetical protein 3206810 6226895 MMAR_2627 Mycobacterium marinum M hypothetical protein YP_001850928.1 3205581 D 216594 CDS YP_001850929.1 183982638 6226896 3206855..3207853 1 NC_010612.1 hypothetical protein 3207853 6226896 MMAR_2628 Mycobacterium marinum M hypothetical protein YP_001850929.1 3206855 D 216594 CDS YP_001850930.1 183982639 6226897 complement(3208470..3209621) 1 NC_010612.1 glycosyl transferase family protein 3209621 6226897 MMAR_2629 Mycobacterium marinum M glycosyl transferase family protein YP_001850930.1 3208470 R 216594 CDS YP_001850931.1 183982640 6226898 complement(3209724..3210593) 1 NC_010612.1 function unknown but contains signal peptide; hypothetical protein 3210593 6226898 MMAR_2630 Mycobacterium marinum M hypothetical protein YP_001850931.1 3209724 R 216594 CDS YP_001850932.1 183982641 6226899 complement(3210646..3211818) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 143A3 Cyp143A3 3211818 cyp143A3 6226899 cyp143A3 Mycobacterium marinum M cytochrome P450 143A3 Cyp143A3 YP_001850932.1 3210646 R 216594 CDS YP_001850933.1 183982642 6226900 complement(3211980..3212600) 1 NC_010612.1 function unknown - contains signal peptide; hypothetical protein 3212600 6226900 MMAR_2632 Mycobacterium marinum M hypothetical protein YP_001850933.1 3211980 R 216594 CDS YP_001850934.1 183982643 6226901 3212830..3213723 1 NC_010612.1 short-chain type dehydrogenase/reductase 3213723 6226901 MMAR_2633 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001850934.1 3212830 D 216594 CDS YP_001850935.1 183982644 6226902 3214051..3215445 1 NC_010612.1 hypothetical protein 3215445 6226902 MMAR_2634 Mycobacterium marinum M hypothetical protein YP_001850935.1 3214051 D 216594 CDS YP_001850936.1 183982645 6226903 3215591..3216376 1 NC_010612.1 hypothetical protein 3216376 6226903 MMAR_2635 Mycobacterium marinum M hypothetical protein YP_001850936.1 3215591 D 216594 CDS YP_001850937.1 183982646 6226904 3216376..3216759 1 NC_010612.1 hypothetical protein 3216759 6226904 MMAR_2636 Mycobacterium marinum M hypothetical protein YP_001850937.1 3216376 D 216594 CDS YP_001850938.1 183982647 6226905 complement(3216799..3217257) 1 NC_010612.1 hypothetical protein 3217257 6226905 MMAR_2637 Mycobacterium marinum M hypothetical protein YP_001850938.1 3216799 R 216594 CDS YP_001850939.1 183982648 6226906 3217556..3218185 1 NC_010612.1 involved in transcriptional mechanism; AcrR family transcriptional regulator 3218185 6226906 MMAR_2638 Mycobacterium marinum M AcrR family transcriptional regulator YP_001850939.1 3217556 D 216594 CDS YP_001850940.1 183982649 6226907 complement(3218299..3218946) 1 NC_010612.1 hypothetical protein 3218946 6226907 MMAR_2639 Mycobacterium marinum M hypothetical protein YP_001850940.1 3218299 R 216594 CDS YP_001850941.1 183982650 6226908 3219058..3219711 1 NC_010612.1 could cause methylation of unknown substrate; methyltransferase 3219711 6226908 MMAR_2640 Mycobacterium marinum M methyltransferase YP_001850941.1 3219058 D 216594 CDS YP_001850942.1 183982651 6226909 complement(3219778..3220152) 1 NC_010612.1 thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions; thioredoxin TrxB1 3220152 trxB1_1 6226909 trxB1_1 Mycobacterium marinum M thioredoxin TrxB1 YP_001850942.1 3219778 R 216594 CDS YP_001850943.1 183982652 6226910 3220288..3220557 1 NC_010612.1 hypothetical protein 3220557 6226910 MMAR_2642 Mycobacterium marinum M hypothetical protein YP_001850943.1 3220288 D 216594 CDS YP_001850944.1 183982653 6226911 3220591..3221016 1 NC_010612.1 hypothetical protein 3221016 6226911 MMAR_2643 Mycobacterium marinum M hypothetical protein YP_001850944.1 3220591 D 216594 CDS YP_001850945.1 183982654 6226912 3221071..3221433 1 NC_010612.1 hypothetical protein 3221433 6226912 MMAR_2644 Mycobacterium marinum M hypothetical protein YP_001850945.1 3221071 D 216594 CDS YP_001850946.1 183982655 6226913 3221630..3223507 1 NC_010612.1 function unknown. has fibronectin-binding activity (could thus mediate bacterial attachment to host cells). thought to be expressed during infection; PE-PGRS family protein 3223507 6226913 MMAR_2645 Mycobacterium marinum M PE-PGRS family protein YP_001850946.1 3221630 D 216594 CDS YP_001850947.1 183982656 6226914 3223666..3224907 1 NC_010612.1 hypothetical protein 3224907 6226914 MMAR_2646 Mycobacterium marinum M hypothetical protein YP_001850947.1 3223666 D 216594 CDS YP_001850948.1 183982657 6226915 3224975..3226180 1 NC_010612.1 function unknown but contains aminopeptidase domain identity; hypothetical protein 3226180 6226915 MMAR_2647 Mycobacterium marinum M hypothetical protein YP_001850948.1 3224975 D 216594 CDS YP_001850949.1 183982658 6226916 3226177..3227463 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 3227463 6226916 MMAR_2648 Mycobacterium marinum M oxidoreductase YP_001850949.1 3226177 D 216594 CDS YP_001850950.1 183982659 6226917 3227572..3228936 1 NC_010612.1 hypothetical protein 3228936 6226917 MMAR_2649 Mycobacterium marinum M hypothetical protein YP_001850950.1 3227572 D 216594 CDS YP_001850951.1 183982660 6226918 3229779..3231065 1 NC_010612.1 PPE family protein 3231065 6226918 MMAR_2650 Mycobacterium marinum M PPE family protein YP_001850951.1 3229779 D 216594 CDS YP_001850952.1 183982661 6226919 complement(3231405..3231959) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 3231959 6226919 MMAR_2651 Mycobacterium marinum M transcriptional regulatory protein YP_001850952.1 3231405 R 216594 CDS YP_001850953.1 183982662 6226922 3233144..3234358 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 144A4 Cyp144A4 3234358 cyp144A4 6226922 cyp144A4 Mycobacterium marinum M cytochrome P450 144A4 Cyp144A4 YP_001850953.1 3233144 D 216594 CDS YP_001850954.1 183982663 6226923 complement(3234414..3235013) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 3235013 6226923 MMAR_2655 Mycobacterium marinum M transcriptional regulatory protein YP_001850954.1 3234414 R 216594 CDS YP_001850955.1 183982664 6226924 3235425..3241781 1 NC_010612.1 PE-PGRS family protein 3241781 6226924 MMAR_2656 Mycobacterium marinum M PE-PGRS family protein YP_001850955.1 3235425 D 216594 CDS YP_001850956.1 183982665 6226925 complement(3241796..3242368) 1 NC_010612.1 function unknown but this protein family are hydrolase enzymes; isochorismatase family protein 3242368 6226925 MMAR_2657 Mycobacterium marinum M isochorismatase family protein YP_001850956.1 3241796 R 216594 CDS YP_001850957.1 183982666 6226926 complement(3242602..3243051) 1 NC_010612.1 hypothetical protein 3243051 6226926 MMAR_2659 Mycobacterium marinum M hypothetical protein YP_001850957.1 3242602 R 216594 CDS YP_001850958.1 183982667 6226927 complement(3243270..3245102) 1 NC_010612.1 hypothetical protein 3245102 6226927 MMAR_2660 Mycobacterium marinum M hypothetical protein YP_001850958.1 3243270 R 216594 CDS YP_001850959.1 183982668 6226928 3245328..3245891 1 NC_010612.1 hypothetical protein 3245891 6226928 MMAR_2661 Mycobacterium marinum M hypothetical protein YP_001850959.1 3245328 D 216594 CDS YP_001850960.1 183982669 6226929 3246229..3246486 1 NC_010612.1 hypothetical protein 3246486 6226929 MMAR_2662 Mycobacterium marinum M hypothetical protein YP_001850960.1 3246229 D 216594 CDS YP_001850961.1 183982670 6226930 complement(3246594..3248765) 1 NC_010612.1 transfers a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan; 4-alpha-glucanotransferase 3248765 malQ 6226930 malQ Mycobacterium marinum M 4-alpha-glucanotransferase YP_001850961.1 3246594 R 216594 CDS YP_001850962.1 183982671 6226931 3249090..3250613 1 NC_010612.1 hypothetical protein 3250613 6226931 MMAR_2664 Mycobacterium marinum M hypothetical protein YP_001850962.1 3249090 D 216594 CDS YP_001850963.1 183982672 6226932 3250610..3254776 1 NC_010612.1 function unknown but has multiple FtsK/SpoIIIE protein domains. this domain contains a putative ATP binding P-loop motif and is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE; FtsK/SpoIIIE family protein 3254776 6226932 MMAR_2665 Mycobacterium marinum M FtsK/SpoIIIE family protein YP_001850963.1 3250610 D 216594 CDS YP_001850964.1 183982673 6226933 complement(3254808..3255983) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 143A4 Cyp143A4 3255983 cyp143A4 6226933 cyp143A4 Mycobacterium marinum M cytochrome P450 143A4 Cyp143A4 YP_001850964.1 3254808 R 216594 CDS YP_001850965.1 183982674 6226934 3256246..3256440 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin 3256440 6226934 MMAR_2667 Mycobacterium marinum M ferredoxin YP_001850965.1 3256246 D 216594 CDS YP_001850966.1 183982675 6226935 3256637..3256828 1 NC_010612.1 hypothetical protein 3256828 6226935 MMAR_2668 Mycobacterium marinum M hypothetical protein YP_001850966.1 3256637 D 216594 CDS YP_001850967.1 183982676 6226936 3256977..3258233 1 NC_010612.1 PPE family protein 3258233 6226936 MMAR_2669 Mycobacterium marinum M PPE family protein YP_001850967.1 3256977 D 216594 CDS YP_001850968.1 183982677 6226937 3258432..3258731 1 NC_010612.1 PE family protein 3258731 6226937 MMAR_2670 Mycobacterium marinum M PE family protein YP_001850968.1 3258432 D 216594 CDS YP_001850969.1 183982678 6226938 3258743..3259969 1 NC_010612.1 PPE family protein 3259969 6226938 MMAR_2671 Mycobacterium marinum M PPE family protein YP_001850969.1 3258743 D 216594 CDS YP_001850970.1 183982679 6226939 3260043..3260363 1 NC_010612.1 hypothetical protein 3260363 6226939 MMAR_2672 Mycobacterium marinum M hypothetical protein YP_001850970.1 3260043 D 216594 CDS YP_001850971.1 183982680 6226940 3260928..3261227 1 NC_010612.1 PE family protein 3261227 6226940 MMAR_2673 Mycobacterium marinum M PE family protein YP_001850971.1 3260928 D 216594 CDS YP_001850972.1 183982681 6226941 3261571..3261867 1 NC_010612.1 EsaT-6 like protein EsxM 3261867 esxM 6226941 esxM Mycobacterium marinum M EsaT-6 like protein EsxM YP_001850972.1 3261571 D 216594 CDS YP_001850973.1 183982682 6226942 3261919..3262203 1 NC_010612.1 EsaT-6 like protein EsxN 3262203 esxN 6226942 esxN Mycobacterium marinum M EsaT-6 like protein EsxN YP_001850973.1 3261919 D 216594 CDS YP_001850974.1 183982683 6226943 3262292..3263194 1 NC_010612.1 hypothetical protein 3263194 6226943 MMAR_2676 Mycobacterium marinum M hypothetical protein YP_001850974.1 3262292 D 216594 CDS YP_001850975.1 183982684 6226944 3263480..3264991 1 NC_010612.1 hypothetical protein 3264991 6226944 MMAR_2677 Mycobacterium marinum M hypothetical protein YP_001850975.1 3263480 D 216594 CDS YP_001850976.1 183982685 6226945 3264969..3266711 1 NC_010612.1 function unknown proteolytic activity but subtilases are a family of serine proteases that can play a role in posttranslational modification; proline rich membrane-anchored mycosin MycP5 3266711 mycP5 6226945 mycP5 Mycobacterium marinum M proline rich membrane-anchored mycosin MycP5 YP_001850976.1 3264969 D 216594 CDS YP_001850977.1 183982686 6226946 3266708..3267919 1 NC_010612.1 hypothetical protein 3267919 6226946 MMAR_2679 Mycobacterium marinum M hypothetical protein YP_001850977.1 3266708 D 216594 CDS YP_001850978.1 183982687 6226947 3267916..3269748 1 NC_010612.1 function unknown, but domain identity to aaa, ATPase family proteins that have been associated with chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes; hypothetical protein 3269748 6226947 MMAR_2680 Mycobacterium marinum M hypothetical protein YP_001850978.1 3267916 D 216594 CDS YP_001850979.1 183982688 6226948 3270649..3271917 1 NC_010612.1 PPE family protein 3271917 6226948 MMAR_2681 Mycobacterium marinum M PPE family protein YP_001850979.1 3270649 D 216594 CDS YP_001850980.1 183982689 6226949 3272013..3273242 1 NC_010612.1 PPE family protein 3273242 6226949 MMAR_2682 Mycobacterium marinum M PPE family protein YP_001850980.1 3272013 D 216594 CDS YP_001850981.1 183982690 6226950 3274083..3275243 1 NC_010612.1 PPE family protein 3275243 6226950 MMAR_2683 Mycobacterium marinum M PPE family protein YP_001850981.1 3274083 D 216594 CDS YP_001850982.1 183982691 6226951 3276328..3277608 1 NC_010612.1 PPE family protein 3277608 6226951 MMAR_2684 Mycobacterium marinum M PPE family protein YP_001850982.1 3276328 D 216594 CDS YP_001850983.1 183982692 6226952 3277695..3279101 1 NC_010612.1 PPE family protein 3279101 6226952 MMAR_2685 Mycobacterium marinum M PPE family protein YP_001850983.1 3277695 D 216594 CDS YP_001850984.1 183982693 6226953 3279402..3279722 1 NC_010612.1 hypothetical protein 3279722 6226953 MMAR_2686 Mycobacterium marinum M hypothetical protein YP_001850984.1 3279402 D 216594 CDS YP_001850985.1 183982694 6226954 3279930..3280658 1 NC_010612.1 thought to be involved in Mg2+ transport (import). may act as an accessory protein for MgtB so mediating magnesium influx into the cytosol [catalytic activity: ATP + H(2)O + mg(2+)(out) = ADP + phosphate + mg(2+)(in)]; Mg2+ transport p-type ATPase C MgtC 3280658 mgtC 6226954 mgtC Mycobacterium marinum M Mg2+ transport p-type ATPase C MgtC YP_001850985.1 3279930 D 216594 CDS YP_001850986.1 183982695 6226955 complement(3280660..3281859) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; NADH dehydrogenase 3281859 6226955 MMAR_2688 Mycobacterium marinum M NADH dehydrogenase YP_001850986.1 3280660 R 216594 CDS YP_001850987.1 183982696 6226956 complement(3281856..3282017) 1 NC_010612.1 function unknown - weak domain identity with lipase/esterase proteins; hypothetical protein 3282017 6226956 MMAR_2689 Mycobacterium marinum M hypothetical protein YP_001850987.1 3281856 R 216594 CDS YP_001850988.1 183982697 6226957 complement(3282019..3282354) 1 NC_010612.1 function unknown - weak domain identity with lipase/esterase proteins; hypothetical protein 3282354 6226957 MMAR_2690 Mycobacterium marinum M hypothetical protein YP_001850988.1 3282019 R 216594 CDS YP_001850989.1 183982698 6226958 3282658..3283566 1 NC_010612.1 involved in lipid desaturation; membrane-bound C-5 sterol desaturase Erg3 3283566 erg3 6226958 erg3 Mycobacterium marinum M membrane-bound C-5 sterol desaturase Erg3 YP_001850989.1 3282658 D 216594 CDS YP_001850990.1 183982699 6226959 3283687..3284355 1 NC_010612.1 hypothetical protein 3284355 6226959 MMAR_2692 Mycobacterium marinum M hypothetical protein YP_001850990.1 3283687 D 216594 CDS YP_001850991.1 183982700 6226960 3284547..3285047 1 NC_010612.1 hypothetical protein 3285047 6226960 MMAR_2693 Mycobacterium marinum M hypothetical protein YP_001850991.1 3284547 D 216594 CDS YP_001850992.1 183982701 6226961 3285083..3286525 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hypothetical protein 3286525 6226961 MMAR_2694 Mycobacterium marinum M hypothetical protein YP_001850992.1 3285083 D 216594 CDS YP_001850993.1 183982702 6226962 complement(3286571..3289252) 1 NC_010612.1 PE-PGRS family protein 3289252 6226962 MMAR_2695 Mycobacterium marinum M PE-PGRS family protein YP_001850993.1 3286571 R 216594 CDS YP_001850994.1 183982703 6226963 complement(3289819..3291738) 1 NC_010612.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; drug-transport transmembrane ABC transporter ATP-binding protein 3291738 6226963 MMAR_2696 Mycobacterium marinum M drug-transport transmembrane ABC transporter ATP-binding protein YP_001850994.1 3289819 R 216594 CDS YP_001850995.1 183982704 6226964 3291842..3293494 1 NC_010612.1 valine and isoleucine biosynthesis (first step) [catalytic activity : 2-acetolactate + CO(2) = 2 pyruvate]; hypothetical protein 3293494 ilvG 6226964 ilvG Mycobacterium marinum M hypothetical protein YP_001850995.1 3291842 D 216594 CDS YP_001850996.1 183982705 6226965 3293525..3295945 1 NC_010612.1 SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 3295945 secA2 6226965 secA2 Mycobacterium marinum M preprotein translocase subunit SecA YP_001850996.1 3293525 D 216594 CDS YP_001850997.1 183982706 6226966 3296067..3296696 1 NC_010612.1 thought to be involved in cardiolipin biosynthesis; generates cardiolipin from phosphatidylglycerol and CDP- diacylglycerol [catalytic activity : may be: phosphatidylglycerol + phosphatidylglycerol -> cardiolipin + glycerol, or: CDP-diacylglycerol + glycerol 3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate]; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 3296696 pgsA2 6226966 pgsA2 Mycobacterium marinum M CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_001850997.1 3296067 D 216594 CDS YP_001850998.1 183982707 6226967 3296689..3297609 1 NC_010612.1 hypothetical protein 3297609 6226967 MMAR_2700 Mycobacterium marinum M hypothetical protein YP_001850998.1 3296689 D 216594 CDS YP_001850999.1 183982708 6226968 3297671..3298003 1 NC_010612.1 hypothetical protein 3298003 6226968 MMAR_2701 Mycobacterium marinum M hypothetical protein YP_001850999.1 3297671 D 216594 CDS YP_001851000.1 183982709 6226969 3298157..3298918 1 NC_010612.1 hypothetical protein 3298918 6226969 MMAR_2702 Mycobacterium marinum M hypothetical protein YP_001851000.1 3298157 D 216594 CDS YP_001851001.1 183982710 6226970 3298953..3299357 1 NC_010612.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3299357 gcvH 6226970 gcvH Mycobacterium marinum M glycine cleavage system protein H YP_001851001.1 3298953 D 216594 CDS YP_001851002.1 183982711 6226971 3299615..3300103 1 NC_010612.1 function unknown but contains an FHA domain. these domains are involved in nuclear signalling domain and may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine; hypothetical protein 3300103 6226971 MMAR_2704 Mycobacterium marinum M hypothetical protein YP_001851002.1 3299615 D 216594 CDS YP_001851003.1 183982712 6226972 3300100..3300855 1 NC_010612.1 function unknown but high N-terminal domain identity with the MerR helix-turn-helix transcription regulator; putative regulatory protein 3300855 6226972 MMAR_2705 Mycobacterium marinum M putative regulatory protein YP_001851003.1 3300100 D 216594 CDS YP_001851004.1 183982713 6226973 3300996..3301490 1 NC_010612.1 hypothetical protein 3301490 6226973 MMAR_2706 Mycobacterium marinum M hypothetical protein YP_001851004.1 3300996 D 216594 CDS YP_001851005.1 183982714 6226974 3301702..3302400 1 NC_010612.1 function unknown but contains MerR helix-turn-helix transcription regulatory domain; regulatory protein 3302400 6226974 MMAR_2707 Mycobacterium marinum M regulatory protein YP_001851005.1 3301702 D 216594 CDS YP_001851006.1 183982715 6226975 3302763..3305600 1 NC_010612.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 3305600 gcvB 6226975 gcvB Mycobacterium marinum M glycine dehydrogenase YP_001851006.1 3302763 D 216594 CDS YP_001851007.1 183982716 6226976 complement(3305630..3307195) 1 NC_010612.1 PE-PGRS family protein 3307195 6226976 MMAR_2709 Mycobacterium marinum M PE-PGRS family protein YP_001851007.1 3305630 R 216594 CDS YP_001851008.1 183982717 6226977 complement(3307475..3308347) 1 NC_010612.1 may act on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds [catalytic activity: 1-haloalkane + H(2)O, a primary alcohol + halide]; haloalkane dehalogenase 3308347 6226977 MMAR_2710 Mycobacterium marinum M haloalkane dehalogenase YP_001851008.1 3307475 R 216594 CDS YP_001851009.1 183982718 6226978 3308397..3309263 1 NC_010612.1 hydrolase 3309263 6226978 MMAR_2711 Mycobacterium marinum M hydrolase YP_001851009.1 3308397 D 216594 CDS YP_001851010.1 183982719 6226979 complement(3309293..3311500) 1 NC_010612.1 function unknown but weak C-term identity with vWA domain (von willebrand factor type a domain). this domain is found in extracellular proteins, like integrins, and mediates adhesion; hypothetical protein 3311500 6226979 MMAR_2712 Mycobacterium marinum M hypothetical protein YP_001851010.1 3309293 R 216594 CDS YP_001851011.1 183982720 6226980 complement(3311551..3313746) 1 NC_010612.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 3313746 glcB 6226980 glcB Mycobacterium marinum M malate synthase G YP_001851011.1 3311551 R 216594 CDS YP_001851012.1 183982721 6226982 complement(3315825..3316877) 1 NC_010612.1 hypothetical protein 3316877 6226982 MMAR_2715 Mycobacterium marinum M hypothetical protein YP_001851012.1 3315825 R 216594 CDS YP_001851013.1 183982722 6226983 complement(3316874..3318256) 1 NC_010612.1 function unknown - however contains domain identity with TlyC - representative of hemolysins and related proteins containing Cbs domains. Cbs domains are small intracellular modules of unknown function. they are mostly found in 2 or four copies within a protein; hypothetical protein 3318256 6226983 MMAR_2716 Mycobacterium marinum M hypothetical protein YP_001851013.1 3316874 R 216594 CDS YP_001851014.1 183982723 6226984 complement(3318451..3319887) 1 NC_010612.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 3319887 guaB1 6226984 guaB1 Mycobacterium marinum M inosine 5-monophosphate dehydrogenase YP_001851014.1 3318451 R 216594 CDS YP_001851015.1 183982724 6226985 complement(3319919..3321370) 1 NC_010612.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 3321370 gnd1 6226985 gnd1 Mycobacterium marinum M 6-phosphogluconate dehydrogenase YP_001851015.1 3319919 R 216594 CDS YP_001851016.1 183982725 6226986 complement(3321480..3322430) 1 NC_010612.1 function unknown but significant domain identity with HtpX, Zn-dependent protease with chaperone function; hypothetical protein 3322430 6226986 MMAR_2719 Mycobacterium marinum M hypothetical protein YP_001851016.1 3321480 R 216594 CDS YP_001851017.1 183982726 6226987 complement(3322445..3322861) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 3322861 6226987 MMAR_2720 Mycobacterium marinum M transcriptional regulatory protein YP_001851017.1 3322445 R 216594 CDS YP_001851018.1 183982727 6226988 3323288..3323728 1 NC_010612.1 function unknown but domain identity suggests possibly involved in aromatic compound catabolism; hypothetical protein 3323728 6226988 MMAR_2721 Mycobacterium marinum M hypothetical protein YP_001851018.1 3323288 D 216594 CDS YP_001851019.1 183982728 6226989 3323725..3324090 1 NC_010612.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 3324090 ureA 6226989 ureA Mycobacterium marinum M urease subunit gamma YP_001851019.1 3323725 D 216594 CDS YP_001851020.1 183982729 6226990 3324087..3324398 1 NC_010612.1 involved in the conversion of UreA to NH3 [catalytic activity: UreA + H2O = CO2 + 2 NH3]; urease subunit beta UreB 3324398 ureB 6226990 ureB Mycobacterium marinum M urease subunit beta UreB YP_001851020.1 3324087 D 216594 CDS YP_001851021.1 183982730 6226991 3324398..3326131 1 NC_010612.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 3326131 ureC 6226991 ureC Mycobacterium marinum M urease subunit alpha YP_001851021.1 3324398 D 216594 CDS YP_001851022.1 183982731 6226992 3326131..3326766 1 NC_010612.1 required for the insertion of the nickel ion at the active site of the urease protein; urease accessory protein UreF 3326766 ureF 6226992 ureF Mycobacterium marinum M urease accessory protein UreF YP_001851022.1 3326131 D 216594 CDS YP_001851023.1 183982732 6226993 3326777..3327448 1 NC_010612.1 UreG is required for functional incorporation of the urease nickel metallocenter. it is not known whether UreG binds GTP or some other nucleotide; urease accessory protein UreG 3327448 ureG 6226993 ureG Mycobacterium marinum M urease accessory protein UreG YP_001851023.1 3326777 D 216594 CDS YP_001851024.1 183982733 6226994 3327448..3328092 1 NC_010612.1 UreD is involved in activation of the urease enzyme via the UreD-UreF-UreG-urease complex and is required for urease nickel metallocenter assembly; urease accessory protein UreD 3328092 ureD 6226994 ureD Mycobacterium marinum M urease accessory protein UreD YP_001851024.1 3327448 D 216594 CDS YP_001851025.1 183982734 6226995 complement(3328163..3329548) 1 NC_010612.1 transfer of electrons from NADH to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation; NADH dehydrogenase Ndh 3329548 ndh 6226995 ndh Mycobacterium marinum M NADH dehydrogenase Ndh YP_001851025.1 3328163 R 216594 CDS YP_001851026.1 183982735 6226996 complement(3329712..3330635) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 3330635 6226996 MMAR_2729 Mycobacterium marinum M oxidoreductase YP_001851026.1 3329712 R 216594 CDS YP_001851027.1 183982736 6226997 complement(3330686..3331363) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; short chain dehydrogenase 3331363 6226997 MMAR_2730 Mycobacterium marinum M short chain dehydrogenase YP_001851027.1 3330686 R 216594 CDS YP_001851028.1 183982737 6226998 3331650..3332414 1 NC_010612.1 involved in the active transport of molybdenum into the cell across the membrane (import). part of the binding- protein-dependent transport system ModABC; molybdate-binding lipoprotein ModA 3332414 modA 6226998 modA Mycobacterium marinum M molybdate-binding lipoprotein ModA YP_001851028.1 3331650 D 216594 CDS YP_001851029.1 183982738 6226999 3332424..3333218 1 NC_010612.1 part of the binding-protein-dependent transport system ModABC for molybdenum; responsible for the translocation of the substrate across the membrane; molybdenum-transport integral membrane protein ABC transporter ModB 3333218 modB 6226999 modB Mycobacterium marinum M molybdenum-transport integral membrane protein ABC transporter ModB YP_001851029.1 3332424 D 216594 CDS YP_001851030.1 183982739 6227000 complement(3333231..3334064) 1 NC_010612.1 function unknown, but possible involved in lipid metabolism; O-methyltransferase Omt 3334064 omt 6227000 omt Mycobacterium marinum M O-methyltransferase Omt YP_001851030.1 3333231 R 216594 CDS YP_001851031.1 183982740 6227001 3334254..3335711 1 NC_010612.1 function unknown but shows high identity with sulfide-quinone reductase from chlorobium tepidum; hypothetical protein 3335711 6227001 MMAR_2734 Mycobacterium marinum M hypothetical protein YP_001851031.1 3334254 D 216594 CDS YP_001851032.1 183982741 6227002 3335708..3335908 1 NC_010612.1 hypothetical protein 3335908 6227002 MMAR_2735 Mycobacterium marinum M hypothetical protein YP_001851032.1 3335708 D 216594 CDS YP_001851033.1 183982742 6227003 3335972..3337213 1 NC_010612.1 part of the binding-protein-dependent transport system ModABC for molybdenum; responsible for energy coupling to the transport system; molybdenum-transport ABC transporter ATP-binding protein ModC 3337213 modC 6227003 modC Mycobacterium marinum M molybdenum-transport ABC transporter ATP-binding protein ModC YP_001851033.1 3335972 D 216594 CDS YP_001851034.1 183982743 6227004 3337300..3338304 1 NC_010612.1 function unknown could mediate bacterial attachment to host cells; alanine and proline rich secreted protein Apa 3338304 apa 6227004 apa Mycobacterium marinum M alanine and proline rich secreted protein Apa YP_001851034.1 3337300 D 216594 CDS YP_001851035.1 183982744 6227005 3338460..3338756 1 NC_010612.1 hypothetical protein 3338756 6227005 MMAR_2738 Mycobacterium marinum M hypothetical protein YP_001851035.1 3338460 D 216594 CDS YP_001851036.1 183982745 6227006 3338849..3339850 1 NC_010612.1 catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD; alcohol dehydrogenase AdhA 3339850 adhA 6227006 adhA Mycobacterium marinum M alcohol dehydrogenase AdhA YP_001851036.1 3338849 D 216594 CDS YP_001851037.1 183982746 6227007 complement(3339857..3340621) 1 NC_010612.1 hypothetical protein 3340621 6227007 MMAR_2740 Mycobacterium marinum M hypothetical protein YP_001851037.1 3339857 R 216594 CDS YP_001851038.1 183982747 6227008 complement(3340918..3341592) 1 NC_010612.1 hypothetical protein 3341592 6227008 MMAR_2741 Mycobacterium marinum M hypothetical protein YP_001851038.1 3340918 R 216594 CDS YP_001851039.1 183982748 6227009 complement(3341817..3344219) 1 NC_010612.1 bacterial enzyme that splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-p and/or acetyl-P and glyeraldehyde-3-p; putative phosphoketolase 3344219 xfp 6227009 xfp Mycobacterium marinum M putative phosphoketolase YP_001851039.1 3341817 R 216594 CDS YP_001851040.1 183982749 6227010 complement(3344265..3345122) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; short chain dehydrogenase 3345122 6227010 MMAR_2743 Mycobacterium marinum M short chain dehydrogenase YP_001851040.1 3344265 R 216594 CDS YP_001851041.1 183982750 6227011 3345230..3345775 1 NC_010612.1 function unknown but contains acetyltransferase domain identity; acetyltransferase 3345775 6227011 MMAR_2744 Mycobacterium marinum M acetyltransferase YP_001851041.1 3345230 D 216594 CDS YP_001851042.1 183982751 6227012 3345884..3348322 1 NC_010612.1 function unknown, but possible involvement in lipid metabolism; acyl-CoA transferase/dehydratase 3348322 6227012 MMAR_2745 Mycobacterium marinum M acyl-CoA transferase/dehydratase YP_001851042.1 3345884 D 216594 CDS YP_001851043.1 183982752 6227013 3348408..3349892 1 NC_010612.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3349892 6227013 MMAR_2746 Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001851043.1 3348408 D 216594 CDS YP_001851044.1 183982753 6227014 3350005..3352113 1 NC_010612.1 function unknown but contains nucleoside- diphosphate-sugar epimerase domain identity - a domain associated with cell envelope biogenesis, carbohydrate transport and metabolism; hypothetical protein 3352113 6227014 MMAR_2747 Mycobacterium marinum M hypothetical protein YP_001851044.1 3350005 D 216594 CDS YP_001851045.1 183982754 6227015 complement(3352215..3352661) 1 NC_010612.1 hypothetical protein 3352661 6227015 MMAR_2748 Mycobacterium marinum M hypothetical protein YP_001851045.1 3352215 R 216594 CDS YP_001851046.1 183982755 6227016 complement(3352785..3353117) 1 NC_010612.1 hypothetical protein 3353117 6227016 MMAR_2749 Mycobacterium marinum M hypothetical protein YP_001851046.1 3352785 R 216594 CDS YP_001851047.1 183982756 6227017 complement(3353120..3353509) 1 NC_010612.1 hypothetical protein 3353509 6227017 MMAR_2750 Mycobacterium marinum M hypothetical protein YP_001851047.1 3353120 R 216594 CDS YP_001851048.1 183982757 6227018 complement(3353614..3355938) 1 NC_010612.1 function unknown but probably plays a role in posttranslational protein modification, turnover and chaperone functions; Lon, ATP-dependent Lon protease 3355938 lon 6227018 lon Mycobacterium marinum M Lon, ATP-dependent Lon protease YP_001851048.1 3353614 R 216594 CDS YP_001851049.1 183982758 6227019 complement(3356060..3357304) 1 NC_010612.1 involved in respiration; catalyzes conversion of lactate into pyruvate [catalytic activity: (S)-lactate + 2 ferricytochrome C = pyruvate + 2 ferrocytochrome C]; L-lactate dehydrogenase (cytochrome) LldD2 3357304 lldD2 6227019 lldD2 Mycobacterium marinum M L-lactate dehydrogenase (cytochrome) LldD2 YP_001851049.1 3356060 R 216594 CDS YP_001851050.1 183982759 6227020 complement(3357465..3358754) 1 NC_010612.1 involved in trehalose biosynthesis (protective effect). converts maltose to trehalose. mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)- linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway); trehalose synthase TreS 3358754 treS_1 6227020 treS_1 Mycobacterium marinum M trehalose synthase TreS YP_001851050.1 3357465 R 216594 CDS YP_001851051.1 183982760 6227021 complement(3358783..3359319) 1 NC_010612.1 involved in oxidative stress response; alkyl hydroperoxide reductase D protein AhpD 3359319 ahpD 6227021 ahpD Mycobacterium marinum M alkyl hydroperoxide reductase D protein AhpD YP_001851051.1 3358783 R 216594 CDS YP_001851052.1 183982761 6227022 complement(3359360..3359947) 1 NC_010612.1 involved in oxidative stress response; alkyl hydroperoxide reductase C protein AhpC 3359947 ahpC 6227022 ahpC Mycobacterium marinum M alkyl hydroperoxide reductase C protein AhpC YP_001851052.1 3359360 R 216594 CDS YP_001851053.1 183982762 6227023 3360045..3361004 1 NC_010612.1 hydrogen peroxide-inducible genes activator, OxyR 3361004 oxyR 6227023 oxyR Mycobacterium marinum M hydrogen peroxide-inducible genes activator, OxyR YP_001851053.1 3360045 D 216594 CDS YP_001851054.1 183982763 6227024 3361039..3361752 1 NC_010612.1 hypothetical protein 3361752 6227024 MMAR_2757 Mycobacterium marinum M hypothetical protein YP_001851054.1 3361039 D 216594 CDS YP_001851055.1 183982764 6227025 3361749..3362192 1 NC_010612.1 hypothetical protein 3362192 6227025 MMAR_2758 Mycobacterium marinum M hypothetical protein YP_001851055.1 3361749 D 216594 CDS YP_001851056.1 183982765 6227026 3362202..3362960 1 NC_010612.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_6 3362960 echA8_6 6227026 echA8_6 Mycobacterium marinum M enoyl-CoA hydratase, EchA8_6 YP_001851056.1 3362202 D 216594 CDS YP_001851057.1 183982766 6227027 complement(3362991..3363167) 1 NC_010612.1 function unknown but like upstream ORF, contains bacterioferritin-associated ferredoxin domain; hypothetical protein 3363167 6227027 MMAR_2760 Mycobacterium marinum M hypothetical protein YP_001851057.1 3362991 R 216594 CDS YP_001851058.1 183982767 6227028 3363475..3363954 1 NC_010612.1 involved in iron storage (may perform analogous functions in iron detoxification and storage as that of animal ferritins); ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited; bacterioferritin BfrA 3363954 bfrA 6227028 bfrA Mycobacterium marinum M bacterioferritin BfrA YP_001851058.1 3363475 D 216594 CDS YP_001851059.1 183982768 6227029 3364396..3364890 1 NC_010612.1 hypothetical protein 3364890 6227029 MMAR_2762 Mycobacterium marinum M hypothetical protein YP_001851059.1 3364396 D 216594 CDS YP_001851060.1 183982769 6227030 3364930..3366291 1 NC_010612.1 involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate]; glutamine synthetase 3366291 glnA3 6227030 glnA3 Mycobacterium marinum M glutamine synthetase YP_001851060.1 3364930 D 216594 CDS YP_001851061.1 183982770 6227031 3366295..3367449 1 NC_010612.1 hypothetical protein 3367449 6227031 MMAR_2764 Mycobacterium marinum M hypothetical protein YP_001851061.1 3366295 D 216594 CDS YP_001851062.1 183982771 6227032 3367446..3368852 1 NC_010612.1 function unknown; involved in cellular metabolism; amidase 3368852 6227032 MMAR_2765 Mycobacterium marinum M amidase YP_001851062.1 3367446 D 216594 CDS YP_001851063.1 183982772 6227033 3369477..3373943 1 NC_010612.1 involved in lipid metabolism. single module of C, a (Phe or trp), T, C domains; non-ribosomal peptide synthetase 3373943 6227033 MMAR_2766 Mycobacterium marinum M non-ribosomal peptide synthetase YP_001851063.1 3369477 D 216594 CDS YP_001851064.1 183982773 6227034 complement(3374015..3374473) 1 NC_010612.1 hypothetical protein 3374473 6227034 MMAR_2767 Mycobacterium marinum M hypothetical protein YP_001851064.1 3374015 R 216594 CDS YP_001851065.1 183982774 6227035 complement(3374577..3375893) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 140A5 Cyp140A5 3375893 cyp140A5 6227035 cyp140A5 Mycobacterium marinum M cytochrome P450 140A5 Cyp140A5 YP_001851065.1 3374577 R 216594 CDS YP_001851066.1 183982775 6227036 complement(3376004..3376426) 1 NC_010612.1 lipoprotein LppE 3376426 lppE 6227036 lppE Mycobacterium marinum M lipoprotein LppE YP_001851066.1 3376004 R 216594 CDS YP_001851067.1 183982776 6227037 complement(3376468..3377301) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; short chain dehydrogenase 3377301 6227037 MMAR_2770 Mycobacterium marinum M short chain dehydrogenase YP_001851067.1 3376468 R 216594 CDS YP_001851068.1 183982777 6227038 complement(3377316..3377750) 1 NC_010612.1 hypothetical protein 3377750 6227038 MMAR_2771 Mycobacterium marinum M hypothetical protein YP_001851068.1 3377316 R 216594 CDS YP_001851069.1 183982778 6227039 complement(3377830..3378243) 1 NC_010612.1 thought to promote the resuscitation and growth of dormant, nongrowing cell. could also stimulate the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis; resuscitation-promoting factor-like protein 3378243 6227039 MMAR_2772 Mycobacterium marinum M resuscitation-promoting factor-like protein YP_001851069.1 3377830 R 216594 CDS YP_001851070.1 183982779 6227040 complement(3378362..3378970) 1 NC_010612.1 catalyzes the interconversion of chorismate to prephenate; chorismate mutase 3378970 6227040 MMAR_2773 Mycobacterium marinum M chorismate mutase YP_001851070.1 3378362 R 216594 CDS YP_001851071.1 183982780 6227041 complement(3378987..3379832) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 3379832 6227041 MMAR_2774 Mycobacterium marinum M oxidoreductase YP_001851071.1 3378987 R 216594 CDS YP_001851072.1 183982781 6227042 complement(3379912..3380919) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 3380919 6227042 MMAR_2775 Mycobacterium marinum M oxidoreductase YP_001851072.1 3379912 R 216594 CDS YP_001851073.1 183982782 6227043 3381042..3381632 1 NC_010612.1 hypothetical protein 3381632 6227043 MMAR_2776 Mycobacterium marinum M hypothetical protein YP_001851073.1 3381042 D 216594 CDS YP_001851074.1 183982783 6227044 complement(3381716..3382693) 1 NC_010612.1 involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity; secreted antigen 85-B FbpB 3382693 fbpB 6227044 fbpB Mycobacterium marinum M secreted antigen 85-B FbpB YP_001851074.1 3381716 R 216594 CDS YP_001851075.1 183982784 6227045 complement(3382784..3383335) 1 NC_010612.1 hypothetical protein 3383335 6227045 MMAR_2778 Mycobacterium marinum M hypothetical protein YP_001851075.1 3382784 R 216594 CDS YP_001851076.1 183982785 6227046 3383408..3384550 1 NC_010612.1 hypothetical protein 3384550 6227046 MMAR_2779 Mycobacterium marinum M hypothetical protein YP_001851076.1 3383408 D 216594 CDS YP_001851077.1 183982786 6227047 complement(3384570..3385241) 1 NC_010612.1 hypothetical protein 3385241 6227047 MMAR_2780 Mycobacterium marinum M hypothetical protein YP_001851077.1 3384570 R 216594 CDS YP_001851078.1 183982787 6227048 complement(3385416..3386000) 1 NC_010612.1 function unknown but some similarity with YceI-like family proteins. in E. coli YceI is a base-induced periplasmic protein. its function has not yet been characterised; hypothetical protein 3386000 6227048 MMAR_2781 Mycobacterium marinum M hypothetical protein YP_001851078.1 3385416 R 216594 CDS YP_001851079.1 183982788 6227049 complement(3385997..3387010) 1 NC_010612.1 generates aldehyde or ketone from alcohol [catalytic activity: alcohol + NADP(+) = aldehyde or ketone + NADPH]; NADP-dependent alcohol dehydrogenase AdhC 3387010 adhC 6227049 adhC Mycobacterium marinum M NADP-dependent alcohol dehydrogenase AdhC YP_001851079.1 3385997 R 216594 CDS YP_001851080.1 183982789 6227050 complement(3387035..3388321) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 125A6 Cyp125A6 3388321 cyp125A6 6227050 cyp125A6 Mycobacterium marinum M cytochrome P450 125A6 Cyp125A6 YP_001851080.1 3387035 R 216594 CDS YP_001851081.1 183982790 6227051 3388775..3389179 1 NC_010612.1 hypothetical protein 3389179 6227051 MMAR_2784 Mycobacterium marinum M hypothetical protein YP_001851081.1 3388775 D 216594 CDS YP_001851082.1 183982791 6227052 3389197..3389490 1 NC_010612.1 hypothetical protein 3389490 6227052 MMAR_2785 Mycobacterium marinum M hypothetical protein YP_001851082.1 3389197 D 216594 CDS YP_001851083.1 183982792 6227053 3389564..3389782 1 NC_010612.1 hypothetical protein 3389782 6227053 MMAR_2786 Mycobacterium marinum M hypothetical protein YP_001851083.1 3389564 D 216594 CDS YP_001851084.1 183982793 6227054 complement(3389833..3390960) 1 NC_010612.1 hypothetical protein 3390960 6227054 MMAR_2787 Mycobacterium marinum M hypothetical protein YP_001851084.1 3389833 R 216594 CDS YP_001851085.1 183982794 6227055 complement(3391110..3391571) 1 NC_010612.1 hypothetical protein 3391571 6227055 MMAR_2788 Mycobacterium marinum M hypothetical protein YP_001851085.1 3391110 R 216594 CDS YP_001851086.1 183982795 6227056 3391871..3393802 1 NC_010612.1 function unknown; involved in cellular metabolism; monooxygenase 3393802 6227056 MMAR_2789 Mycobacterium marinum M monooxygenase YP_001851086.1 3391871 D 216594 CDS YP_001851087.1 183982796 6227057 3393813..3394838 1 NC_010612.1 function unknown, probably involved in cellular metabolism; dehydrogenase 3394838 6227057 MMAR_2790 Mycobacterium marinum M dehydrogenase YP_001851087.1 3393813 D 216594 CDS YP_001851088.1 183982797 6227058 complement(3394828..3395739) 1 NC_010612.1 function unknown but significant domain identity with O-Methyltransferases involved in polyketide biosynthesis; hypothetical protein 3395739 6227058 MMAR_2791 Mycobacterium marinum M hypothetical protein YP_001851088.1 3394828 R 216594 CDS YP_001851089.1 183982798 6227059 complement(3395781..3396212) 1 NC_010612.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 3396212 6227059 MMAR_2792 Mycobacterium marinum M D-tyrosyl-tRNA(Tyr) deacylase YP_001851089.1 3395781 R 216594 CDS YP_001851090.1 183982799 6227060 3396509..3396835 1 NC_010612.1 hypothetical protein 3396835 6227060 MMAR_2793 Mycobacterium marinum M hypothetical protein YP_001851090.1 3396509 D 216594 CDS YP_001851091.1 183982800 6227061 complement(3396832..3397326) 1 NC_010612.1 Truncated wrt to orthologues, missing last 12aa - potential pseudogene; function unknown but contains predicted phosphatase domain; lipoprotein LppD 3397326 lppD 6227061 lppD Mycobacterium marinum M lipoprotein LppD YP_001851091.1 3396832 R 216594 CDS YP_001851092.1 183982801 6227062 3397556..3397861 1 NC_010612.1 PE-PGRS family protein 3397861 6227062 MMAR_2795 Mycobacterium marinum M PE-PGRS family protein YP_001851092.1 3397556 D 216594 CDS YP_001851093.1 183982802 6227063 3397978..3399255 1 NC_010612.1 CinA is the first gene in the competence-inducible (cin) operon, and is thought to be specifically required at some stage in the process of transformation; competence damage-inducible protein A 3399255 cinA 6227063 cinA Mycobacterium marinum M competence damage-inducible protein A YP_001851093.1 3397978 D 216594 CDS YP_001851094.1 183982803 6227064 complement(3399351..3400610) 1 NC_010612.1 transport of sialic acid across the membrane. responsible for the translocation of the substrate across the membrane; sialic acid-transport integral membrane protein NanT 3400610 nanT 6227064 nanT Mycobacterium marinum M sialic acid-transport integral membrane protein NanT YP_001851094.1 3399351 R 216594 CDS YP_001851095.1 183982804 6227065 3400686..3401753 1 NC_010612.1 amidohydrolase 3401753 6227065 MMAR_2798 Mycobacterium marinum M amidohydrolase YP_001851095.1 3400686 D 216594 CDS YP_001851096.1 183982805 6227066 3401770..3402171 1 NC_010612.1 hypothetical protein 3402171 6227066 MMAR_2799 Mycobacterium marinum M hypothetical protein YP_001851096.1 3401770 D 216594 CDS YP_001851097.1 183982806 6227067 3402456..3402896 1 NC_010612.1 hypothetical protein 3402896 6227067 MMAR_2800 Mycobacterium marinum M hypothetical protein YP_001851097.1 3402456 D 216594 CDS YP_001851098.1 183982807 6227068 complement(3402911..3403894) 1 NC_010612.1 wide specificity for D-amino acids. also acts on glycine [catalytic activity: a D-amino acid + H2O + O2 = a 2-OXO acid + NH3 + H2O2]; D-amino acid oxidase Aao 3403894 aao 6227068 aao Mycobacterium marinum M D-amino acid oxidase Aao YP_001851098.1 3402911 R 216594 CDS YP_001851099.1 183982808 6227069 complement(3403907..3404425) 1 NC_010612.1 hypothetical protein 3404425 6227069 MMAR_2802 Mycobacterium marinum M hypothetical protein YP_001851099.1 3403907 R 216594 CDS YP_001851100.1 183982809 6227070 complement(3404426..3404851) 1 NC_010612.1 hypothetical protein 3404851 6227070 MMAR_2803 Mycobacterium marinum M hypothetical protein YP_001851100.1 3404426 R 216594 CDS YP_001851101.1 183982810 6227071 complement(3404839..3405564) 1 NC_010612.1 hypothetical protein 3405564 6227071 MMAR_2804 Mycobacterium marinum M hypothetical protein YP_001851101.1 3404839 R 216594 CDS YP_001851102.1 183982811 6227072 complement(3405988..3406425) 1 NC_010612.1 hypothetical protein 3406425 6227072 MMAR_2805 Mycobacterium marinum M hypothetical protein YP_001851102.1 3405988 R 216594 CDS YP_001851103.1 183982812 6227073 complement(3406422..3407663) 1 NC_010612.1 PPE family protein 3407663 6227073 MMAR_2806 Mycobacterium marinum M PPE family protein YP_001851103.1 3406422 R 216594 CDS YP_001851104.1 183982813 6227076 complement(3408518..3409150) 1 NC_010612.1 hypothetical protein 3409150 6227076 MMAR_2809 Mycobacterium marinum M hypothetical protein YP_001851104.1 3408518 R 216594 CDS YP_001851105.1 183982814 6227077 3409293..3410231 1 NC_010612.1 function unknown; contains putative metal-dependent hydrolase domain; hypothetical protein 3410231 6227077 MMAR_2810 Mycobacterium marinum M hypothetical protein YP_001851105.1 3409293 D 216594 CDS YP_001851106.1 183982815 6227078 3410231..3411364 1 NC_010612.1 hypothetical protein 3411364 6227078 MMAR_2811 Mycobacterium marinum M hypothetical protein YP_001851106.1 3410231 D 216594 CDS YP_001851107.1 183982816 6227079 complement(3411751..3412350) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 3412350 6227079 MMAR_2812 Mycobacterium marinum M TetR family transcriptional regulator YP_001851107.1 3411751 R 216594 CDS YP_001851108.1 183982817 6227080 3412465..3414045 1 NC_010612.1 function unknown, probably involved in cellular metabolism; dehydrogenase 3414045 6227080 MMAR_2813 Mycobacterium marinum M dehydrogenase YP_001851108.1 3412465 D 216594 CDS YP_001851109.1 183982818 6227081 complement(3414096..3415100) 1 NC_010612.1 thought to be involved in fatty acid degradation. FadB and FadA are the alpha and beta subunits of the multifunctional enzyme complex of the fatty acid degradation cycle; oxidoreductase FadB5 3415100 fadB5 6227081 fadB5 Mycobacterium marinum M oxidoreductase FadB5 YP_001851109.1 3414096 R 216594 CDS YP_001851110.1 183982819 6227082 complement(3415143..3415571) 1 NC_010612.1 hypothetical protein 3415571 6227082 MMAR_2815 Mycobacterium marinum M hypothetical protein YP_001851110.1 3415143 R 216594 CDS YP_001851111.1 183982820 6227083 complement(3415568..3415894) 1 NC_010612.1 involved in transcriptional regulation; ArsR-type repressor 3415894 6227083 MMAR_2816 Mycobacterium marinum M ArsR-type repressor YP_001851111.1 3415568 R 216594 CDS YP_001851112.1 183982821 6227084 complement(3415953..3416804) 1 NC_010612.1 hypothetical protein 3416804 6227084 MMAR_2817 Mycobacterium marinum M hypothetical protein YP_001851112.1 3415953 R 216594 CDS YP_001851113.1 183982822 6227085 complement(3416816..3417079) 1 NC_010612.1 hypothetical protein 3417079 6227085 MMAR_2818 Mycobacterium marinum M hypothetical protein YP_001851113.1 3416816 R 216594 CDS YP_001851114.1 183982823 6227086 3417126..3417848 1 NC_010612.1 hypothetical protein 3417848 6227086 MMAR_2819 Mycobacterium marinum M hypothetical protein YP_001851114.1 3417126 D 216594 CDS YP_001851115.1 183982824 6227087 complement(3417855..3418223) 1 NC_010612.1 hypothetical protein 3418223 6227087 MMAR_2820 Mycobacterium marinum M hypothetical protein YP_001851115.1 3417855 R 216594 CDS YP_001851116.1 183982825 6227088 3418358..3420646 1 NC_010612.1 involved in glyoxylate bypass, an alternative to the tricarboxylic acid cycle [catalytic activity: isocitrate = succinate + glyoxylate]; isocitrate lyase AceAb 3420646 aceAb 6227088 aceAb Mycobacterium marinum M isocitrate lyase AceAb YP_001851116.1 3418358 D 216594 CDS YP_001851117.1 183982826 6227089 complement(3420742..3423807) 1 NC_010612.1 PPE family protein 3423807 6227089 MMAR_2822 Mycobacterium marinum M PPE family protein YP_001851117.1 3420742 R 216594 CDS YP_001851118.1 183982827 6227090 3424577..3424987 1 NC_010612.1 PE-PGRS family protein 3424987 6227090 MMAR_2823 Mycobacterium marinum M PE-PGRS family protein YP_001851118.1 3424577 D 216594 CDS YP_001851119.1 183982828 6227091 3425132..3426295 1 NC_010612.1 monooxygenase 3426295 6227091 MMAR_2824 Mycobacterium marinum M monooxygenase YP_001851119.1 3425132 D 216594 CDS YP_001851120.1 183982829 6227092 complement(3426346..3426813) 1 NC_010612.1 hypothetical protein 3426813 6227092 MMAR_2825 Mycobacterium marinum M hypothetical protein YP_001851120.1 3426346 R 216594 CDS YP_001851121.1 183982830 6227093 3426951..3427775 1 NC_010612.1 hypothetical protein 3427775 6227093 MMAR_2826 Mycobacterium marinum M hypothetical protein YP_001851121.1 3426951 D 216594 CDS YP_001851122.1 183982831 6227094 3427940..3429235 1 NC_010612.1 lipoprotein 3429235 6227094 MMAR_2827 Mycobacterium marinum M lipoprotein YP_001851122.1 3427940 D 216594 CDS YP_001851123.1 183982832 6227095 3429357..3430640 1 NC_010612.1 function unknown, lipolytic enzyme probably involved in cellular metabolism; lipase LipD 3430640 lipD 6227095 lipD Mycobacterium marinum M lipase LipD YP_001851123.1 3429357 D 216594 CDS YP_001851124.1 183982833 6227096 complement(3430661..3431482) 1 NC_010612.1 hypothetical protein 3431482 6227096 MMAR_2829 Mycobacterium marinum M hypothetical protein YP_001851124.1 3430661 R 216594 CDS YP_001851125.1 183982834 6227097 complement(3431629..3434247) 1 NC_010612.1 hypothetical protein 3434247 6227097 MMAR_2830 Mycobacterium marinum M hypothetical protein YP_001851125.1 3431629 R 216594 CDS YP_001851126.1 183982835 6227098 complement(3434946..3435488) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulator 3435488 6227098 MMAR_2831 Mycobacterium marinum M transcriptional regulator YP_001851126.1 3434946 R 216594 CDS YP_001851127.1 183982836 6227099 complement(3435697..3437703) 1 NC_010612.1 hypothetical protein 3437703 6227099 MMAR_2832 Mycobacterium marinum M hypothetical protein YP_001851127.1 3435697 R 216594 CDS YP_001851128.1 183982837 6227100 complement(3437706..3438329) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 3438329 6227100 MMAR_2833 Mycobacterium marinum M TetR family transcriptional regulator YP_001851128.1 3437706 R 216594 CDS YP_001851129.1 183982838 6227101 complement(3438882..3439304) 1 NC_010612.1 hypothetical protein 3439304 6227101 MMAR_2834 Mycobacterium marinum M hypothetical protein YP_001851129.1 3438882 R 216594 CDS YP_001851130.1 183982839 6227102 3439417..3441291 1 NC_010612.1 activates fatty acids by binding to coenzyme A; putative fatty-acid--CoA ligase 3441291 fadD31 6227102 fadD31 Mycobacterium marinum M putative fatty-acid--CoA ligase YP_001851130.1 3439417 D 216594 CDS YP_001851131.1 183982840 6227103 complement(3441295..3443157) 1 NC_010612.1 phosphotransferase 3443157 6227103 MMAR_2836 Mycobacterium marinum M phosphotransferase YP_001851131.1 3441295 R 216594 CDS YP_001851132.1 183982841 6227104 complement(3443238..3443843) 1 NC_010612.1 hypothetical protein 3443843 6227104 MMAR_2837 Mycobacterium marinum M hypothetical protein YP_001851132.1 3443238 R 216594 CDS YP_001851133.1 183982842 6227105 complement(3443934..3444467) 1 NC_010612.1 hypothetical protein 3444467 6227105 MMAR_2838 Mycobacterium marinum M hypothetical protein YP_001851133.1 3443934 R 216594 CDS YP_001851134.1 183982843 6227106 complement(3444526..3445005) 1 NC_010612.1 16 kDa immunogenic extracellular protein): function unknown; immunogenic protein Mpt63 3445005 6227106 MMAR_2839 Mycobacterium marinum M immunogenic protein Mpt63 YP_001851134.1 3444526 R 216594 CDS YP_001851135.1 183982844 6227107 3445237..3447564 1 NC_010612.1 thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]; arylsulfatase AtsD_2 3447564 atsD_2 6227107 atsD_2 Mycobacterium marinum M arylsulfatase AtsD_2 YP_001851135.1 3445237 D 216594 CDS YP_001851136.1 183982845 6227108 3447659..3448420 1 NC_010612.1 hypothetical protein 3448420 6227108 MMAR_2841 Mycobacterium marinum M hypothetical protein YP_001851136.1 3447659 D 216594 CDS YP_001851137.1 183982846 6227109 complement(3448457..3449314) 1 NC_010612.1 function unknown - domain identity suggests Na+- dependant transporter; hypothetical protein 3449314 6227109 MMAR_2842 Mycobacterium marinum M hypothetical protein YP_001851137.1 3448457 R 216594 CDS YP_001851138.1 183982847 6227110 complement(3449384..3450382) 1 NC_010612.1 hypothetical protein 3450382 6227110 MMAR_2843 Mycobacterium marinum M hypothetical protein YP_001851138.1 3449384 R 216594 CDS YP_001851139.1 183982848 6227111 3450733..3452121 1 NC_010612.1 catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway.; hydroxydechloroatrazine ethylaminohydrolase 3452121 6227111 MMAR_2844 Mycobacterium marinum M hydroxydechloroatrazine ethylaminohydrolase YP_001851139.1 3450733 D 216594 CDS YP_001851140.1 183982849 6227112 complement(3452542..3453237) 1 NC_010612.1 alkyl hydroperoxidase; catalyze the reduction of hydrogen peroxide to water and the reduction of alkyl hydroperoxides to the corresponding alcohols; peroxiredoxin 3453237 ahpC_1 6227112 ahpC_1 Mycobacterium marinum M peroxiredoxin YP_001851140.1 3452542 R 216594 CDS YP_001851141.1 183982850 6227113 3453451..3454920 1 NC_010612.1 function unknown: involved in carbohydrate transport and metabolism; alpha-L-fucosidase 3454920 6227113 MMAR_2846 Mycobacterium marinum M alpha-L-fucosidase YP_001851141.1 3453451 D 216594 CDS YP_001851142.1 183982851 6227114 3454991..3455404 1 NC_010612.1 hypothetical protein 3455404 6227114 MMAR_2847 Mycobacterium marinum M hypothetical protein YP_001851142.1 3454991 D 216594 CDS YP_001851143.1 183982852 6227115 3455501..3456274 1 NC_010612.1 hypothetical protein 3456274 6227115 MMAR_2848 Mycobacterium marinum M hypothetical protein YP_001851143.1 3455501 D 216594 CDS YP_001851144.1 183982853 6227116 complement(3456322..3457089) 1 NC_010612.1 function unknown; probably involved in cellular metabolism; short chain dehydrogenase 3457089 6227116 MMAR_2849 Mycobacterium marinum M short chain dehydrogenase YP_001851144.1 3456322 R 216594 CDS YP_001851145.1 183982854 6227117 3457137..3457622 1 NC_010612.1 hypothetical protein 3457622 6227117 MMAR_2850 Mycobacterium marinum M hypothetical protein YP_001851145.1 3457137 D 216594 CDS YP_001851146.1 183982855 6227118 3457654..3458508 1 NC_010612.1 function unknown but has weak indentity with hydrolase domains; hypothetical protein 3458508 6227118 MMAR_2851 Mycobacterium marinum M hypothetical protein YP_001851146.1 3457654 D 216594 CDS YP_001851147.1 183982856 6227119 complement(3458539..3459099) 1 NC_010612.1 function unknown but contains dihydrofolate reductase domain; hypothetical protein 3459099 6227119 MMAR_2852 Mycobacterium marinum M hypothetical protein YP_001851147.1 3458539 R 216594 CDS YP_001851148.1 183982857 6227120 3459197..3459661 1 NC_010612.1 hypothetical protein 3459661 6227120 MMAR_2853 Mycobacterium marinum M hypothetical protein YP_001851148.1 3459197 D 216594 CDS YP_001851149.1 183982858 6227121 complement(3459718..3460461) 1 NC_010612.1 hypothetical protein 3460461 6227121 MMAR_2854 Mycobacterium marinum M hypothetical protein YP_001851149.1 3459718 R 216594 CDS YP_001851150.1 183982859 6227122 complement(3460480..3461430) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 3461430 6227122 MMAR_2855 Mycobacterium marinum M transcriptional regulatory protein YP_001851150.1 3460480 R 216594 CDS YP_001851151.1 183982860 6227123 complement(3461592..3463013) 1 NC_010612.1 Short-chain fatty acids transporter 3463013 6227123 MMAR_2857 Mycobacterium marinum M Short-chain fatty acids transporter YP_001851151.1 3461592 R 216594 CDS YP_001851152.1 183982861 6227124 complement(3463010..3463210) 1 NC_010612.1 hypothetical protein 3463210 6227124 MMAR_5580 Mycobacterium marinum M hypothetical protein YP_001851152.1 3463010 R 216594 CDS YP_001851153.1 183982862 6227125 3463454..3463849 1 NC_010612.1 hypothetical protein 3463849 6227125 MMAR_2858 Mycobacterium marinum M hypothetical protein YP_001851153.1 3463454 D 216594 CDS YP_001851154.1 183982863 6227126 3463887..3465056 1 NC_010612.1 function unknown but domain identity with Fe-S oxidoreductases; oxidoreductase 3465056 6227126 MMAR_2859 Mycobacterium marinum M oxidoreductase YP_001851154.1 3463887 D 216594 CDS YP_001851155.1 183982864 6227127 3465144..3465641 1 NC_010612.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 3465641 tpx 6227127 tpx Mycobacterium marinum M thiol peroxidase YP_001851155.1 3465144 D 216594 CDS YP_001851156.1 183982865 6227128 complement(3465663..3466751) 1 NC_010612.1 function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase FadE18 3466751 fadE18 6227128 fadE18 Mycobacterium marinum M acyl-CoA dehydrogenase FadE18 YP_001851156.1 3465663 R 216594 CDS YP_001851157.1 183982866 6227129 complement(3466753..3467982) 1 NC_010612.1 function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase FadE17 3467982 fadE17 6227129 fadE17 Mycobacterium marinum M acyl-CoA dehydrogenase FadE17 YP_001851157.1 3466753 R 216594 CDS YP_001851158.1 183982867 6227130 complement(3468000..3468950) 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3468950 echA13 6227130 echA13 Mycobacterium marinum M enoyl-CoA hydratase YP_001851158.1 3468000 R 216594 CDS YP_001851159.1 183982868 6227131 3469186..3470322 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxygenase 3470322 6227131 MMAR_2864 Mycobacterium marinum M oxygenase YP_001851159.1 3469186 D 216594 CDS YP_001851160.1 183982869 6227132 3470350..3472869 1 NC_010612.1 function unknown, may be involved in electron transfer; oxygenase 3472869 6227132 MMAR_2865 Mycobacterium marinum M oxygenase YP_001851160.1 3470350 D 216594 CDS YP_001851161.1 183982870 6227133 3472881..3473939 1 NC_010612.1 this enzyme acts on epoxides (alkene oxides, oxiranes) and Arene oxides. plays a role in xenobiotic metabolism by degrading potential toxic epoxides. also determines steady-state levels of physiological mediators; epoxide hydrolase EphB 3473939 ephB 6227133 ephB Mycobacterium marinum M epoxide hydrolase EphB YP_001851161.1 3472881 D 216594 CDS YP_001851162.1 183982871 6227134 3473936..3474469 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreducatse 3474469 6227134 MMAR_2867 Mycobacterium marinum M oxidoreducatse YP_001851162.1 3473936 D 216594 CDS YP_001851163.1 183982872 6227135 3474466..3475563 1 NC_010612.1 involved in riboflavin biosynthesis [catalytic activity : GTP + 3 H(2)O = formate + 2,5-diamino-6-hydroxy- 4-(5-phosphoribosylamino)pyrimidine + diphosphate]; riboflavin biosynthesis protein RibA1 3475563 ribA1 6227135 ribA1 Mycobacterium marinum M riboflavin biosynthesis protein RibA1 YP_001851163.1 3474466 D 216594 CDS YP_001851164.1 183982873 6227136 3475567..3476337 1 NC_010612.1 function unknown, probably involved in cellular metabolism; short-chain type dehydrogenase/reductase 3476337 6227136 MMAR_2869 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001851164.1 3475567 D 216594 CDS YP_001851165.1 183982874 6227137 complement(3476356..3477165) 1 NC_010612.1 hypothetical protein 3477165 6227137 MMAR_2870 Mycobacterium marinum M hypothetical protein YP_001851165.1 3476356 R 216594 CDS YP_001851166.1 183982875 6227138 3477414..3477764 1 NC_010612.1 hypothetical protein 3477764 6227138 MMAR_2871 Mycobacterium marinum M hypothetical protein YP_001851166.1 3477414 D 216594 CDS YP_001851167.1 183982876 6227139 3478149..3478463 1 NC_010612.1 maybe required for the translocation of the substrate across the membrane; multidrug-transport integral membrane protein Mmr-like protein 3478463 6227139 MMAR_2872 Mycobacterium marinum M multidrug-transport integral membrane protein Mmr-like protein YP_001851167.1 3478149 D 216594 CDS YP_001851168.1 183982877 6227140 complement(3478785..3479987) 1 NC_010612.1 involved in transcriptional mechanism; repression of the Mce3 operon. could also have a regulatory action on the Mce2 operon; TetR family transcriptional regulator 3479987 mce3R 6227140 mce3R Mycobacterium marinum M TetR family transcriptional regulator YP_001851168.1 3478785 R 216594 CDS YP_001851169.1 183982878 6227141 3480470..3480889 1 NC_010612.1 hypothetical protein 3480889 6227141 MMAR_2874 Mycobacterium marinum M hypothetical protein YP_001851169.1 3480470 D 216594 CDS YP_001851170.1 183982879 6227142 3480886..3482409 1 NC_010612.1 thought to oxidize a wide variety of aliphatic and aromatic aldehydes; aldehyde dehydrogenase 3482409 6227142 MMAR_2875 Mycobacterium marinum M aldehyde dehydrogenase YP_001851170.1 3480886 D 216594 CDS YP_001851171.1 183982880 6227143 complement(3482412..3483599) 1 NC_010612.1 function unknown but weak domain identity with two- component response regulators; putative regulatory protein 3483599 6227143 MMAR_2876 Mycobacterium marinum M putative regulatory protein YP_001851171.1 3482412 R 216594 CDS YP_001851172.1 183982881 6227144 3483725..3485008 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 278A1 Cyp278A1 3485008 cyp278A1 6227144 cyp278A1 Mycobacterium marinum M cytochrome P450 278A1 Cyp278A1 YP_001851172.1 3483725 D 216594 CDS YP_001851173.1 183982882 6227145 3485005..3485421 1 NC_010612.1 function unknown, domain identity with ketosteroid isomerase-related proteins; hypothetical protein 3485421 6227145 MMAR_2878 Mycobacterium marinum M hypothetical protein YP_001851173.1 3485005 D 216594 CDS YP_001851174.1 183982883 6227146 3485418..3485612 1 NC_010612.1 ferredoxin 3485612 6227146 MMAR_2879 Mycobacterium marinum M ferredoxin YP_001851174.1 3485418 D 216594 CDS YP_001851175.1 183982884 6227147 3485922..3486770 1 NC_010612.1 integral membrane protein YrbE3A 3486770 yrbE3A 6227147 yrbE3A Mycobacterium marinum M integral membrane protein YrbE3A YP_001851175.1 3485922 D 216594 CDS YP_001851176.1 183982885 6227148 3486780..3487634 1 NC_010612.1 function unknown, but probably part of Mce3 operon and member of YrbE family; integral membrane protein, YrbE3B 3487634 yrbE3B 6227148 yrbE3B Mycobacterium marinum M integral membrane protein, YrbE3B YP_001851176.1 3486780 D 216594 CDS YP_001851177.1 183982886 6227149 3487639..3489024 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3A 3489024 mce3A 6227149 mce3A Mycobacterium marinum M MCE-family protein Mce3A YP_001851177.1 3487639 D 216594 CDS YP_001851178.1 183982887 6227150 3489100..3490128 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3B 3490128 mce3B 6227150 mce3B Mycobacterium marinum M MCE-family protein Mce3B YP_001851178.1 3489100 D 216594 CDS YP_001851179.1 183982888 6227151 3490125..3491408 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3C 3491408 mce3C 6227151 mce3C Mycobacterium marinum M MCE-family protein Mce3C YP_001851179.1 3490125 D 216594 CDS YP_001851180.1 183982889 6227152 3491405..3492688 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3D 3492688 mce3D 6227152 mce3D Mycobacterium marinum M MCE-family protein Mce3D YP_001851180.1 3491405 D 216594 CDS YP_001851181.1 183982890 6227153 3492688..3493857 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE family lipoprotein LprM 3493857 lprM 6227153 lprM Mycobacterium marinum M MCE family lipoprotein LprM YP_001851181.1 3492688 D 216594 CDS YP_001851182.1 183982891 6227154 3493858..3495321 1 NC_010612.1 function unknown, but thought involved in host cell invasion; MCE-family protein Mce3F 3495321 mce3F 6227154 mce3F Mycobacterium marinum M MCE-family protein Mce3F YP_001851182.1 3493858 D 216594 CDS YP_001851183.1 183982892 6227155 3495365..3495928 1 NC_010612.1 Mce associated membrane protein 3495928 6227155 MMAR_2888 Mycobacterium marinum M Mce associated membrane protein YP_001851183.1 3495365 D 216594 CDS YP_001851184.1 183982893 6227156 3495925..3496497 1 NC_010612.1 Mce associated membrane protein 3496497 6227156 MMAR_2889 Mycobacterium marinum M Mce associated membrane protein YP_001851184.1 3495925 D 216594 CDS YP_001851185.1 183982894 6227157 3496559..3497224 1 NC_010612.1 hypothetical protein 3497224 6227157 MMAR_2890 Mycobacterium marinum M hypothetical protein YP_001851185.1 3496559 D 216594 CDS YP_001851186.1 183982895 6227158 complement(3497305..3497673) 1 NC_010612.1 hypothetical protein 3497673 6227158 MMAR_2891 Mycobacterium marinum M hypothetical protein YP_001851186.1 3497305 R 216594 CDS YP_001851187.1 183982896 6227159 complement(3497766..3498176) 1 NC_010612.1 hypothetical protein 3498176 6227159 MMAR_2892 Mycobacterium marinum M hypothetical protein YP_001851187.1 3497766 R 216594 CDS YP_001851188.1 183982897 6227160 complement(3498254..3498532) 1 NC_010612.1 hypothetical protein 3498532 6227160 MMAR_2893 Mycobacterium marinum M hypothetical protein YP_001851188.1 3498254 R 216594 CDS YP_001851189.1 183982898 6227161 complement(3498706..3499398) 1 NC_010612.1 PE family protein 3499398 6227161 MMAR_2894 Mycobacterium marinum M PE family protein YP_001851189.1 3498706 R 216594 CDS YP_001851190.1 183982899 6227162 3500872..3502071 1 NC_010612.1 PPE family protein 3502071 6227162 MMAR_2895 Mycobacterium marinum M PPE family protein YP_001851190.1 3500872 D 216594 CDS YP_001851191.1 183982900 6227163 3502651..3503553 1 NC_010612.1 function unknown - possible role in cell-wall biogenesis; nucleoside-diphosphate-sugar epimerase WcaG-like protein 3503553 6227163 MMAR_2896 Mycobacterium marinum M nucleoside-diphosphate-sugar epimerase WcaG-like protein YP_001851191.1 3502651 D 216594 CDS YP_001851192.1 183982901 6227164 3503732..3504550 1 NC_010612.1 function unknown: some similarity to pMUM CDS, hypothetical protein MUP016c; hypothetical protein 3504550 6227164 MMAR_2897 Mycobacterium marinum M hypothetical protein YP_001851192.1 3503732 D 216594 CDS YP_001851193.1 183982902 6227165 3504547..3505284 1 NC_010612.1 function unknown; some similarity to MUP015c from pMUM001; hypothetical protein 3505284 6227165 MMAR_2898 Mycobacterium marinum M hypothetical protein YP_001851193.1 3504547 D 216594 CDS YP_001851194.1 183982903 6227166 complement(3505396..3505662) 1 NC_010612.1 hypothetical protein 3505662 6227166 MMAR_2899 Mycobacterium marinum M hypothetical protein YP_001851194.1 3505396 R 216594 CDS YP_001851195.1 183982904 6227167 complement(3505822..3506082) 1 NC_010612.1 this protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; iron-regulated elongation factor Tu Tuf-like protein 3506082 6227167 MMAR_2900 Mycobacterium marinum M iron-regulated elongation factor Tu Tuf-like protein YP_001851195.1 3505822 R 216594 CDS YP_001851196.1 183982905 6227168 3506156..3506524 1 NC_010612.1 hypothetical protein 3506524 6227168 MMAR_2901 Mycobacterium marinum M hypothetical protein YP_001851196.1 3506156 D 216594 CDS YP_001851197.1 183982906 6227169 complement(3506556..3507389) 1 NC_010612.1 possibly hydrolyzes specific sugar (hydrolyzation of glycosidic bond) and could be involved in exopolysaccharide biosynthesis/degradation. could also have a lytic activity against cell walls; beta-1,3-glucanase 3507389 6227169 MMAR_2902 Mycobacterium marinum M beta-1,3-glucanase YP_001851197.1 3506556 R 216594 CDS YP_001851198.1 183982907 6227170 complement(3507458..3508471) 1 NC_010612.1 NADP-dependent oxidoreductase 3508471 6227170 MMAR_2903 Mycobacterium marinum M NADP-dependent oxidoreductase YP_001851198.1 3507458 R 216594 CDS YP_001851199.1 183982908 6227171 3508570..3509427 1 NC_010612.1 O-methyltransferase 3509427 6227171 MMAR_2904 Mycobacterium marinum M O-methyltransferase YP_001851199.1 3508570 D 216594 CDS YP_001851200.1 183982909 6227172 3509697..3509957 1 NC_010612.1 hypothetical protein 3509957 6227172 MMAR_2905 Mycobacterium marinum M hypothetical protein YP_001851200.1 3509697 D 216594 CDS YP_001851201.1 183982910 6227173 3510060..3511106 1 NC_010612.1 function unknown but some domain identity with Zn- dependent proteases; hypothetical protein 3511106 6227173 MMAR_2906 Mycobacterium marinum M hypothetical protein YP_001851201.1 3510060 D 216594 CDS YP_001851202.1 183982911 6227174 complement(3511116..3512270) 1 NC_010612.1 function unknown; contains serine proteinase inhibitors (serpin) domain homology; hypothetical protein 3512270 6227174 MMAR_2907 Mycobacterium marinum M hypothetical protein YP_001851202.1 3511116 R 216594 CDS YP_001851203.1 183982912 6227175 complement(3512283..3512978) 1 NC_010612.1 hydrolysis of cutin (a polyester that forms the structure of plant cuticle); cutinase 3512978 6227175 MMAR_2908 Mycobacterium marinum M cutinase YP_001851203.1 3512283 R 216594 CDS YP_001851204.1 183982913 6227177 3513567..3513797 1 NC_010612.1 hypothetical protein 3513797 6227177 MMAR_2910 Mycobacterium marinum M hypothetical protein YP_001851204.1 3513567 D 216594 CDS YP_001851205.1 183982914 6227178 3513841..3514191 1 NC_010612.1 hypothetical protein 3514191 6227178 MMAR_2911 Mycobacterium marinum M hypothetical protein YP_001851205.1 3513841 D 216594 CDS YP_001851206.1 183982915 6227179 3514344..3515207 1 NC_010612.1 hydrolase or acyltransferase 3515207 6227179 MMAR_2912 Mycobacterium marinum M hydrolase or acyltransferase YP_001851206.1 3514344 D 216594 CDS YP_001851207.1 183982916 6227180 3515567..3517363 1 NC_010612.1 high-affinity uptake of glycine betaine. supposed responsible for the translocation of the substrate across the membrane; glycine betaine transport integral membrane protein BetP 3517363 betP 6227180 betP Mycobacterium marinum M glycine betaine transport integral membrane protein BetP YP_001851207.1 3515567 D 216594 CDS YP_001851208.1 183982917 6227181 complement(3517457..3519688) 1 NC_010612.1 multifunctional enzyme, exhibiting both a catalase, a broad-spectrum peroxidase, and a peroxynitritase activities. may play a role in the intracellular survival of mycobacteria within macrophages; protection against reactive oxygen and nitrogen intermediates produced by phagocytic cells. seems regulated by SigB [catalytic activity: 2 H(2)O(2) = O(2) + 2 H(2)O]; catalase-peroxidase-peroxynitritase T KatG 3519688 katG 6227181 katG Mycobacterium marinum M catalase-peroxidase-peroxynitritase T KatG YP_001851208.1 3517457 R 216594 CDS YP_001851209.1 183982918 6227182 complement(3519725..3520141) 1 NC_010612.1 acts as a global negative controlling element, employing fe(2+) as a cofactor to bind the operator of the repressed genes. seems to regulate transcription of KatG gene; ferric uptake regulation protein FurA 3520141 furA 6227182 furA Mycobacterium marinum M ferric uptake regulation protein FurA YP_001851209.1 3519725 R 216594 CDS YP_001851210.1 183982919 6227183 3520507..3520956 1 NC_010612.1 hypothetical protein 3520956 6227183 MMAR_2916 Mycobacterium marinum M hypothetical protein YP_001851210.1 3520507 D 216594 CDS YP_001851211.1 183982920 6227184 3521124..3521993 1 NC_010612.1 hypothetical protein 3521993 6227184 MMAR_2917 Mycobacterium marinum M hypothetical protein YP_001851211.1 3521124 D 216594 CDS YP_001851212.1 183982921 6227185 complement(3522027..3522881) 1 NC_010612.1 may be a sulfotransferase involved in the formation of thiosulfate [catalytic activity: thiosulfate + cyanide = sulfite + thiocyanate]; thiosulfate sulfotransferase 3522881 6227185 MMAR_2918 Mycobacterium marinum M thiosulfate sulfotransferase YP_001851212.1 3522027 R 216594 CDS YP_001851213.1 183982922 6227186 complement(3523014..3523709) 1 NC_010612.1 hypothetical protein 3523709 6227186 MMAR_2919 Mycobacterium marinum M hypothetical protein YP_001851213.1 3523014 R 216594 CDS YP_001851214.1 183982923 6227187 3523957..3524820 1 NC_010612.1 adds the distal cyclopropane ring to alpha-meroacid in mycolic acid biosynthesis. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase; methoxy mycolic acid synthase 2 MmaA2 3524820 mmaA2_1 6227187 mmaA2_1 Mycobacterium marinum M methoxy mycolic acid synthase 2 MmaA2 YP_001851214.1 3523957 D 216594 CDS YP_001851215.1 183982924 6227188 3525354..3525632 1 NC_010612.1 hypothetical protein 3525632 6227188 MMAR_2921 Mycobacterium marinum M hypothetical protein YP_001851215.1 3525354 D 216594 CDS YP_001851216.1 183982925 6227189 3525739..3526422 1 NC_010612.1 methylation of unknown substrate; O-methyltransferase 3526422 6227189 MMAR_2922 Mycobacterium marinum M O-methyltransferase YP_001851216.1 3525739 D 216594 CDS YP_001851217.1 183982926 6227190 complement(3526403..3527455) 1 NC_010612.1 hypothetical protein 3527455 6227190 MMAR_2923 Mycobacterium marinum M hypothetical protein YP_001851217.1 3526403 R 216594 CDS YP_001851218.1 183982927 6227191 complement(3527466..3528224) 1 NC_010612.1 methylation of unknown substrate; SAM-dependent methyltransferase 3528224 6227191 MMAR_2924 Mycobacterium marinum M SAM-dependent methyltransferase YP_001851218.1 3527466 R 216594 CDS YP_001851219.1 183982928 6227192 complement(3528218..3529477) 1 NC_010612.1 glycosyltransferase 3529477 6227192 MMAR_2925 Mycobacterium marinum M glycosyltransferase YP_001851219.1 3528218 R 216594 CDS YP_001851220.1 183982929 6227193 complement(3529642..3530742) 1 NC_010612.1 function unknown; possible role in deamination [amino acid transport and metabolism]; glycine/D-amino acid oxidase 3530742 6227193 MMAR_2926 Mycobacterium marinum M glycine/D-amino acid oxidase YP_001851220.1 3529642 R 216594 CDS YP_001851221.1 183982930 6227194 complement(3530907..3531320) 1 NC_010612.1 function unknown; contains a putative glyoxalase domain; hypothetical protein 3531320 6227194 MMAR_2927 Mycobacterium marinum M hypothetical protein YP_001851221.1 3530907 R 216594 CDS YP_001851222.1 183982931 6227195 3531548..3532876 1 NC_010612.1 PPE family protein 3532876 6227195 MMAR_2928 Mycobacterium marinum M PPE family protein YP_001851222.1 3531548 D 216594 CDS YP_001851223.1 183982932 6227196 3533230..3533553 1 NC_010612.1 hypothetical protein 3533553 6227196 MMAR_2929 Mycobacterium marinum M hypothetical protein YP_001851223.1 3533230 D 216594 CDS YP_001851224.1 183982933 6227197 complement(3533667..3534935) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 147G1 Cyp147G1 3534935 cyp147G1 6227197 cyp147G1 Mycobacterium marinum M cytochrome P450 147G1 Cyp147G1 YP_001851224.1 3533667 R 216594 CDS YP_001851225.1 183982934 6227198 complement(3534978..3536381) 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. probably the reductase required for cytochrome P-450 function; ferredoxin reductase 3536381 6227198 MMAR_2931 Mycobacterium marinum M ferredoxin reductase YP_001851225.1 3534978 R 216594 CDS YP_001851226.1 183982935 6227199 complement(3536378..3536593) 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. probably the reductase required for cytochrome P-450 function; ferredoxin reductase FdxD 3536593 6227199 MMAR_2932 Mycobacterium marinum M ferredoxin reductase FdxD YP_001851226.1 3536378 R 216594 CDS YP_001851227.1 183982936 6227200 3536853..3538514 1 NC_010612.1 PE-PGRS family protein 3538514 6227200 MMAR_2933 Mycobacterium marinum M PE-PGRS family protein YP_001851227.1 3536853 D 216594 CDS YP_001851228.1 183982937 6227201 complement(3538558..3539199) 1 NC_010612.1 hydrolysis of cutin; cutinase Cfp21 3539199 cfp21 6227201 cfp21 Mycobacterium marinum M cutinase Cfp21 YP_001851228.1 3538558 R 216594 CDS YP_001851229.1 183982938 6227202 complement(3539304..3540569) 1 NC_010612.1 hypothetical protein 3540569 6227202 MMAR_2935 Mycobacterium marinum M hypothetical protein YP_001851229.1 3539304 R 216594 CDS YP_001851230.1 183982939 6227203 3540903..3544445 1 NC_010612.1 function unknown, but involved in lipid degradation; fatty-acid-CoA ligase FadD9 3544445 fadD9_1 6227203 fadD9_1 Mycobacterium marinum M fatty-acid-CoA ligase FadD9 YP_001851230.1 3540903 D 216594 CDS YP_001851231.1 183982940 6227204 complement(3544485..3545033) 1 NC_010612.1 hypothetical protein 3545033 6227204 MMAR_2937 Mycobacterium marinum M hypothetical protein YP_001851231.1 3544485 R 216594 CDS YP_001851232.1 183982941 6227205 complement(3545143..3545772) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; nitroreductase 3545772 6227205 MMAR_2938 Mycobacterium marinum M nitroreductase YP_001851232.1 3545143 R 216594 CDS YP_001851233.1 183982942 6227206 3545896..3546441 1 NC_010612.1 possibly involved in transcriptional mechanism; transcriptional regulatory protein 3546441 6227206 MMAR_2939 Mycobacterium marinum M transcriptional regulatory protein YP_001851233.1 3545896 D 216594 CDS YP_001851234.1 183982943 6227207 3546441..3547604 1 NC_010612.1 hypothetical protein 3547604 6227207 MMAR_2940 Mycobacterium marinum M hypothetical protein YP_001851234.1 3546441 D 216594 CDS YP_001851235.1 183982944 6227208 3547745..3549709 1 NC_010612.1 involved in signal transduction (via phosphorylation). thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; membrane-anchored serine/threonine-protein kinase 3549709 6227208 MMAR_2941 Mycobacterium marinum M membrane-anchored serine/threonine-protein kinase YP_001851235.1 3547745 D 216594 CDS YP_001851236.1 183982945 6227209 complement(3549917..3550579) 1 NC_010612.1 function unknown; hypothetical protein 3550579 6227209 MMAR_2942 Mycobacterium marinum M hypothetical protein YP_001851236.1 3549917 R 216594 CDS YP_001851237.1 183982946 6227210 3550668..3551246 1 NC_010612.1 hypothetical protein 3551246 6227210 MMAR_2943 Mycobacterium marinum M hypothetical protein YP_001851237.1 3550668 D 216594 CDS YP_001851238.1 183982947 6227211 complement(3551272..3552981) 1 NC_010612.1 PPE family protein 3552981 6227211 MMAR_2944 Mycobacterium marinum M PPE family protein YP_001851238.1 3551272 R 216594 CDS YP_001851239.1 183982948 6227212 3553803..3554792 1 NC_010612.1 amino acid transport and metabolism; 1-aminocyclopropane-1-carboxylate deaminase 3554792 6227212 MMAR_2945 Mycobacterium marinum M 1-aminocyclopropane-1-carboxylate deaminase YP_001851239.1 3553803 D 216594 CDS YP_001851240.1 183982949 6227213 complement(3555064..3555534) 1 NC_010612.1 hypothetical protein 3555534 6227213 MMAR_2946 Mycobacterium marinum M hypothetical protein YP_001851240.1 3555064 R 216594 CDS YP_001851241.1 183982950 6227214 3555707..3559648 1 NC_010612.1 possibly has helicase activity; HrpA-like helicase 3559648 6227214 MMAR_2947 Mycobacterium marinum M HrpA-like helicase YP_001851241.1 3555707 D 216594 CDS YP_001851242.1 183982951 6227215 3559764..3562364 1 NC_010612.1 PE-PGRS family protein 3562364 6227215 MMAR_2948 Mycobacterium marinum M PE-PGRS family protein YP_001851242.1 3559764 D 216594 CDS YP_001851243.1 183982952 6227216 complement(3562424..3562981) 1 NC_010612.1 function unknown. secreted protein; hypothetical protein 3562981 6227216 MMAR_2949 Mycobacterium marinum M hypothetical protein YP_001851243.1 3562424 R 216594 CDS YP_001851244.1 183982953 6227217 3563583..3564554 1 NC_010612.1 thought to be involved in fatty acid degradation. FadB and FadA are the alpha and beta subunits of the multifunctional enzyme complex of the fatty acid degradation cycle; oxidoreductase 3564554 6227217 MMAR_2950 Mycobacterium marinum M oxidoreductase YP_001851244.1 3563583 D 216594 CDS YP_001851245.1 183982954 6227218 3564747..3565175 1 NC_010612.1 contains a C-term cellobiohydrolase a (1,4- beta-cellobiosidase a) domain and a N-term cellulose- binding domain (CBD) domain. the CBD is found either at the N-term or at the C-term of endoglucanases, cellobiohydrolases (exoglucanases), or xylanases; chitinase/cellulase 3565175 6227218 MMAR_2951 Mycobacterium marinum M chitinase/cellulase YP_001851245.1 3564747 D 216594 CDS YP_001851246.1 183982955 6227219 3565421..3566230 1 NC_010612.1 hypothetical protein 3566230 6227219 MMAR_2952 Mycobacterium marinum M hypothetical protein YP_001851246.1 3565421 D 216594 CDS YP_001851247.1 183982956 6227220 complement(3566323..3567150) 1 NC_010612.1 function unknown. possible secreted protein; hypothetical protein 3567150 6227220 MMAR_2953 Mycobacterium marinum M hypothetical protein YP_001851247.1 3566323 R 216594 CDS YP_001851248.1 183982957 6227221 complement(3567479..3569164) 1 NC_010612.1 function unknown; probably involved in cellular metabolism, probably electron-transfer-linked; dehydrogenase fad flavoprotein GMC oxidoreductase 3569164 6227221 MMAR_2954 Mycobacterium marinum M dehydrogenase fad flavoprotein GMC oxidoreductase YP_001851248.1 3567479 R 216594 CDS YP_001851249.1 183982958 6227222 3569463..3569714 1 NC_010612.1 hypothetical protein 3569714 6227222 MMAR_2955 Mycobacterium marinum M hypothetical protein YP_001851249.1 3569463 D 216594 CDS YP_001851250.1 183982959 6227223 3569704..3570015 1 NC_010612.1 function unknown but in E. coli PemK is a growth inhibitor known to bind to the promoter region of the PEM operon, auto-regulating synthesis; PemK-like protein 3570015 6227223 MMAR_2956 Mycobacterium marinum M PemK-like protein YP_001851250.1 3569704 D 216594 CDS YP_001851251.1 183982960 6227225 3571158..3573353 1 NC_010612.1 macrophage infection protein, MimD 3573353 mimD 6227225 mimD Mycobacterium marinum M macrophage infection protein, MimD YP_001851251.1 3571158 D 216594 CDS YP_001851252.1 183982961 6227226 complement(3573899..3574927) 1 NC_010612.1 function unknown; probably involved in cellular metabolism; Zn-dependent alcohol dehydrogenase 3574927 6227226 MMAR_2959 Mycobacterium marinum M Zn-dependent alcohol dehydrogenase YP_001851252.1 3573899 R 216594 CDS YP_001851253.1 183982962 6227227 3575004..3575603 1 NC_010612.1 function unknown, belongs AcrR family of transcriptional regulators; transcriptional regulatory protein 3575603 6227227 MMAR_2960 Mycobacterium marinum M transcriptional regulatory protein YP_001851253.1 3575004 D 216594 CDS YP_001851254.1 183982963 6227228 3575624..3575956 1 NC_010612.1 hypothetical protein 3575956 6227228 MMAR_2961 Mycobacterium marinum M hypothetical protein YP_001851254.1 3575624 D 216594 CDS YP_001851255.1 183982964 6227229 complement(3576003..3579239) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 3579239 6227229 MMAR_2962 Mycobacterium marinum M transcriptional regulatory protein YP_001851255.1 3576003 R 216594 CDS YP_001851256.1 183982965 6227230 3579465..3581297 1 NC_010612.1 function unknown role in cellular metabolism. contains predicted signal peptide sequence; oxidoreductase 3581297 6227230 MMAR_2963 Mycobacterium marinum M oxidoreductase YP_001851256.1 3579465 D 216594 CDS YP_001851257.1 183982966 6227231 3581248..3584406 1 NC_010612.1 function unknown, but probably involved in sugar or lipid transport. contains a C-term patatin-like phospholipase domain. the patatin family consists of various patatin glycoproteins from plants. the patatin protein accounts for up to 40% of the total soluble protein in potato tubers. patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. this predicted protein also contains multiple membrane-spanning domains and a beta-barrel structure, characteristic of pore-forming membrane proteins; transmembrane transport protein 3584406 6227231 MMAR_2964 Mycobacterium marinum M transmembrane transport protein YP_001851257.1 3581248 D 216594 CDS YP_001851258.1 183982967 6227232 3584821..3585843 1 NC_010612.1 involved in NAD metabolism [coenzyme metabolism]; ATPase/kinase, NadR 3585843 nadR 6227232 nadR Mycobacterium marinum M ATPase/kinase, NadR YP_001851258.1 3584821 D 216594 CDS YP_001851259.1 183982968 6227233 3585953..3587632 1 NC_010612.1 translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; integral membrane drug efflux protein 3587632 6227233 MMAR_2966 Mycobacterium marinum M integral membrane drug efflux protein YP_001851259.1 3585953 D 216594 CDS YP_001851260.1 183982969 6227234 3587686..3588222 1 NC_010612.1 hypothetical protein 3588222 6227234 MMAR_2967 Mycobacterium marinum M hypothetical protein YP_001851260.1 3587686 D 216594 CDS YP_001851261.1 183982970 6227235 3588249..3588974 1 NC_010612.1 hypothetical protein 3588974 6227235 MMAR_2968 Mycobacterium marinum M hypothetical protein YP_001851261.1 3588249 D 216594 CDS YP_001851262.1 183982971 6227236 3589577..3591604 1 NC_010612.1 PE-PGRS family protein 3591604 6227236 MMAR_2969 Mycobacterium marinum M PE-PGRS family protein YP_001851262.1 3589577 D 216594 CDS YP_001851263.1 183982972 6227237 complement(3591944..3593773) 1 NC_010612.1 PE-PGRS family protein 3593773 6227237 MMAR_2970 Mycobacterium marinum M PE-PGRS family protein YP_001851263.1 3591944 R 216594 CDS YP_001851264.1 183982973 6227238 complement(3594195..3595016) 1 NC_010612.1 methylation of unknown substrate; O-methyltransferase 3595016 6227238 MMAR_2971 Mycobacterium marinum M O-methyltransferase YP_001851264.1 3594195 R 216594 CDS YP_001851265.1 183982974 6227239 3595313..3596377 1 NC_010612.1 function unknown but contains a sugar isomerase N- term domain and N and C-term predicted beta-barrels; putative sugar transport protein 3596377 6227239 MMAR_2972 Mycobacterium marinum M putative sugar transport protein YP_001851265.1 3595313 D 216594 CDS YP_001851266.1 183982975 6227240 3596523..3597854 1 NC_010612.1 function unknown; PE-PGRS family protein 3597854 6227240 MMAR_2973 Mycobacterium marinum M PE-PGRS family protein YP_001851266.1 3596523 D 216594 CDS YP_001851267.1 183982976 6227241 complement(3597910..3598743) 1 NC_010612.1 could possibly oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3- hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase 3598743 6227241 MMAR_2974 Mycobacterium marinum M enoyl-CoA hydratase YP_001851267.1 3597910 R 216594 CDS YP_001851268.1 183982977 6227242 complement(3598740..3600152) 1 NC_010612.1 function unknown; hypothetical protein 3600152 6227242 MMAR_2975 Mycobacterium marinum M hypothetical protein YP_001851268.1 3598740 R 216594 CDS YP_001851269.1 183982978 6227243 3600432..3601874 1 NC_010612.1 function unknown; contains a putative flavoprotein domain; hypothetical protein 3601874 6227243 MMAR_2976 Mycobacterium marinum M hypothetical protein YP_001851269.1 3600432 D 216594 CDS YP_001851270.1 183982979 6227244 3601884..3602636 1 NC_010612.1 function unknown; possible role in cleavage of unknown acyl-ACP substrate; acyl-ACP thioesterase, FatA 3602636 fatA 6227244 fatA Mycobacterium marinum M acyl-ACP thioesterase, FatA YP_001851270.1 3601884 D 216594 CDS YP_001851271.1 183982980 6227245 3603061..3604482 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 135B6 Cyp135B6 3604482 cyp135B6 6227245 cyp135B6 Mycobacterium marinum M cytochrome P450 135B6 Cyp135B6 YP_001851271.1 3603061 D 216594 CDS YP_001851272.1 183982981 6227246 3604789..3605397 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 3605397 6227246 MMAR_2979 Mycobacterium marinum M TetR family transcriptional regulator YP_001851272.1 3604789 D 216594 CDS YP_001851273.1 183982982 6227247 3605418..3606500 1 NC_010612.1 function unknown; contains flavin-utilizing monoxygenase domain; hypothetical protein 3606500 6227247 MMAR_2980 Mycobacterium marinum M hypothetical protein YP_001851273.1 3605418 D 216594 CDS YP_001851274.1 183982983 6227248 3606541..3607323 1 NC_010612.1 function unknown; thought to be involved in lipid biosynthesis [catalytic activity: androstan-3-alpha,17- beta-diol + NAD+ = 17-beta-hydroxyandrostan-3-one + NADH]; 20-beta-hydroxysteroid dehydrogenase 3607323 fabG3_1 6227248 fabG3_1 Mycobacterium marinum M 20-beta-hydroxysteroid dehydrogenase YP_001851274.1 3606541 D 216594 CDS YP_001851275.1 183982984 6227249 3607311..3608681 1 NC_010612.1 hypothetical protein 3608681 6227249 MMAR_2982 Mycobacterium marinum M hypothetical protein YP_001851275.1 3607311 D 216594 CDS YP_001851276.1 183982985 6227250 3608847..3609758 1 NC_010612.1 function unknown; contains two universal stress protein family domains. the universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general 'stress endurance' activity; hypothetical protein 3609758 6227250 MMAR_2983 Mycobacterium marinum M hypothetical protein YP_001851276.1 3608847 D 216594 CDS YP_001851277.1 183982986 6227251 complement(3610187..3610858) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 3610858 6227251 MMAR_2984 Mycobacterium marinum M TetR family transcriptional regulator YP_001851277.1 3610187 R 216594 CDS YP_001851278.1 183982987 6227252 3610941..3612113 1 NC_010612.1 involved in the degradation of biphenyl [catalytic activity: biphenyl-2,3-diol + O(2) = 2-hydroxy-6-OXO-6- phenylhexa-2,4-dienoate + H(2)O]; 2,3-dihydroxybiphenyl-1,2-dioxygenase BphC 3612113 bphC_1 6227252 bphC_1 Mycobacterium marinum M 2,3-dihydroxybiphenyl-1,2-dioxygenase BphC YP_001851278.1 3610941 D 216594 CDS YP_001851279.1 183982988 6227253 3612110..3613048 1 NC_010612.1 isomerizes HHDD (2-hydroxy-hept-2,4-diene-1,7- dioate) to ohed (2-OXO-hept-3-ene-1,7-dioate); 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 3613048 6227253 MMAR_2986 Mycobacterium marinum M 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase YP_001851279.1 3612110 D 216594 CDS YP_001851280.1 183982989 6227254 3613045..3614589 1 NC_010612.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 3614589 mhpA 6227254 mhpA Mycobacterium marinum M 3-(3-hydroxyphenyl)propionate hydroxylase YP_001851280.1 3613045 D 216594 CDS YP_001851281.1 183982990 6227255 3614654..3615127 1 NC_010612.1 acetyltransferase 3615127 6227255 MMAR_2988 Mycobacterium marinum M acetyltransferase YP_001851281.1 3614654 D 216594 CDS YP_001851282.1 183982991 6227256 3615342..3615575 1 NC_010612.1 hypothetical protein 3615575 6227256 MMAR_2989 Mycobacterium marinum M hypothetical protein YP_001851282.1 3615342 D 216594 CDS YP_001851283.1 183982992 6227257 complement(3615717..3616115) 1 NC_010612.1 involved in transcriptional regulation (repression) of heat shock proteins E.G. DnaK, GrpE, DnaJ. binds to three inverted repeats (IR1-IR3) in the promoter region of the DnaK operon. induction: by heat shock; heat shock protein transcriptional repressor HspR_2 3616115 hspR_2 6227257 hspR_2 Mycobacterium marinum M heat shock protein transcriptional repressor HspR_2 YP_001851283.1 3615717 R 216594 CDS YP_001851284.1 183982993 6227258 3616260..3616709 1 NC_010612.1 function unknown. may be involved in a chaperoning process; molecular chaperone 3616709 6227258 MMAR_2991 Mycobacterium marinum M molecular chaperone YP_001851284.1 3616260 D 216594 CDS YP_001851285.1 183982994 6227259 3617137..3617865 1 NC_010612.1 involved in the biosynthesis of tetrahydrofolate (at the first step) [catalytic activity: GTP + 2 H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)DiHYD ro pteridine triphosphate]; GTP cyclohydrolase I FolE 3617865 folE_1 6227259 folE_1 Mycobacterium marinum M GTP cyclohydrolase I FolE YP_001851285.1 3617137 D 216594 CDS YP_001851286.1 183982995 6227260 complement(3617900..3618787) 1 NC_010612.1 hypothetical protein 3618787 6227260 MMAR_2993 Mycobacterium marinum M hypothetical protein YP_001851286.1 3617900 R 216594 CDS YP_001851287.1 183982996 6227261 complement(3618804..3619148) 1 NC_010612.1 involved in electron transfer; ferredoxin FdxA_2 3619148 fdxA_2 6227261 fdxA_2 Mycobacterium marinum M ferredoxin FdxA_2 YP_001851287.1 3618804 R 216594 CDS YP_001851288.1 183982997 6227262 complement(3619238..3620122) 1 NC_010612.1 function unknown. possibly involved in signal transduction mechanisms; hypothetical protein 3620122 6227262 MMAR_2995 Mycobacterium marinum M hypothetical protein YP_001851288.1 3619238 R 216594 CDS YP_001851289.1 183982998 6227263 complement(3620291..3620557) 1 NC_010612.1 hypothetical protein 3620557 6227263 MMAR_2996 Mycobacterium marinum M hypothetical protein YP_001851289.1 3620291 R 216594 CDS YP_001851290.1 183982999 6227264 complement(3620554..3621168) 1 NC_010612.1 the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released; alternative RNA polymerase sigma factor 3621168 6227264 MMAR_2997 Mycobacterium marinum M alternative RNA polymerase sigma factor YP_001851290.1 3620554 R 216594 CDS YP_001851291.1 183983000 6227265 complement(3621188..3622255) 1 NC_010612.1 function unknown. possibly involved in lipid metabolism; hypothetical protein 3622255 6227265 MMAR_2998 Mycobacterium marinum M hypothetical protein YP_001851291.1 3621188 R 216594 CDS YP_001851292.1 183983001 6227266 complement(3622427..3622951) 1 NC_010612.1 hypothetical protein 3622951 6227266 MMAR_2999 Mycobacterium marinum M hypothetical protein YP_001851292.1 3622427 R 216594 CDS YP_001851293.1 183983002 6227267 3623110..3623301 1 NC_010612.1 hypothetical protein 3623301 6227267 MMAR_5570 Mycobacterium marinum M hypothetical protein YP_001851293.1 3623110 D 216594 CDS YP_001851294.1 183983003 6227268 complement(3623357..3623647) 1 NC_010612.1 EsaT-6 family protein 3623647 esxR 6227268 esxR Mycobacterium marinum M EsaT-6 family protein YP_001851294.1 3623357 R 216594 CDS YP_001851295.1 183983004 6227269 complement(3623683..3623976) 1 NC_010612.1 EsaT-6 like protein EsxG 3623976 esxG_1 6227269 esxG_1 Mycobacterium marinum M EsaT-6 like protein EsxG YP_001851295.1 3623683 R 216594 CDS YP_001851296.1 183983005 6227270 complement(3624013..3625299) 1 NC_010612.1 PPE family protein 3625299 6227270 MMAR_3002 Mycobacterium marinum M PPE family protein YP_001851296.1 3624013 R 216594 CDS YP_001851297.1 183983006 6227271 complement(3625310..3625615) 1 NC_010612.1 PE family protein 3625615 6227271 MMAR_3003 Mycobacterium marinum M PE family protein YP_001851297.1 3625310 R 216594 CDS YP_001851298.1 183983007 6227272 complement(3626054..3627250) 1 NC_010612.1 PPE family protein 3627250 6227272 MMAR_3005 Mycobacterium marinum M PPE family protein YP_001851298.1 3626054 R 216594 CDS YP_001851299.1 183983008 6227273 complement(3627728..3628918) 1 NC_010612.1 PPE family protein 3628918 6227273 MMAR_3006 Mycobacterium marinum M PPE family protein YP_001851299.1 3627728 R 216594 CDS YP_001851300.1 183983009 6227274 complement(3629592..3630425) 1 NC_010612.1 hypothetical protein 3630425 6227274 MMAR_3007 Mycobacterium marinum M hypothetical protein YP_001851300.1 3629592 R 216594 CDS YP_001851301.1 183983010 6227275 complement(3630635..3632554) 1 NC_010612.1 PE-PGRS family protein 3632554 6227275 MMAR_3008 Mycobacterium marinum M PE-PGRS family protein YP_001851301.1 3630635 R 216594 CDS YP_001851302.1 183983011 6227276 complement(3632717..3633682) 1 NC_010612.1 hypothetical protein 3633682 6227276 MMAR_3010 Mycobacterium marinum M hypothetical protein YP_001851302.1 3632717 R 216594 CDS YP_001851303.1 183983012 6227277 complement(3633785..3634855) 1 NC_010612.1 thought to be involved in active transport of sugar across the membrane (import). responsible for energy coupling to the transport system; sugar-transport ATP-binding protein ABC transporter 3634855 6227277 MMAR_3011 Mycobacterium marinum M sugar-transport ATP-binding protein ABC transporter YP_001851303.1 3633785 R 216594 CDS YP_001851304.1 183983013 6227278 complement(3634861..3635703) 1 NC_010612.1 sugar ABC transporter 3635703 6227278 MMAR_3012 Mycobacterium marinum M sugar ABC transporter YP_001851304.1 3634861 R 216594 CDS YP_001851305.1 183983014 6227279 complement(3635690..3636643) 1 NC_010612.1 thought to be involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane; sugar ABC transporter integral membrane protein 3636643 6227279 MMAR_3013 Mycobacterium marinum M sugar ABC transporter integral membrane protein YP_001851305.1 3635690 R 216594 CDS YP_001851306.1 183983015 6227280 complement(3636640..3637956) 1 NC_010612.1 sugar-binding lipoprotein 3637956 6227280 MMAR_3014 Mycobacterium marinum M sugar-binding lipoprotein YP_001851306.1 3636640 R 216594 CDS YP_001851307.1 183983016 6227281 complement(3638038..3638835) 1 NC_010612.1 hypothetical protein 3638835 6227281 MMAR_3015 Mycobacterium marinum M hypothetical protein YP_001851307.1 3638038 R 216594 CDS YP_001851308.1 183983017 6227282 complement(3638835..3639395) 1 NC_010612.1 converts amides such as nicotinamide to corresponding acid; pyrazinamidase/nicotinamidase, PncA 3639395 pncA 6227282 pncA Mycobacterium marinum M pyrazinamidase/nicotinamidase, PncA YP_001851308.1 3638835 R 216594 CDS YP_001851309.1 183983018 6227283 3639491..3640306 1 NC_010612.1 hypothetical protein 3640306 6227283 MMAR_3017 Mycobacterium marinum M hypothetical protein YP_001851309.1 3639491 D 216594 CDS YP_001851310.1 183983019 6227284 complement(3640303..3640818) 1 NC_010612.1 function unknown, in general gluconate kinase catalyzes the phosphoryl transfer from ATP to gluconate. the resulting product gluconate-6-phosphate is an important precursor of gluconate metabolism; gluconate kinase 3640818 6227284 MMAR_3018 Mycobacterium marinum M gluconate kinase YP_001851310.1 3640303 R 216594 CDS YP_001851311.1 183983020 6227285 complement(3640815..3642815) 1 NC_010612.1 hypothetical protein 3642815 6227285 MMAR_3019 Mycobacterium marinum M hypothetical protein YP_001851311.1 3640815 R 216594 CDS YP_001851312.1 183983021 6227286 complement(3642821..3644326) 1 NC_010612.1 converts unknown esters to corresponding free acid and alcohol; carboxylesterase, LipT 3644326 lipT 6227286 lipT Mycobacterium marinum M carboxylesterase, LipT YP_001851312.1 3642821 R 216594 CDS YP_001851313.1 183983022 6227287 3644405..3645085 1 NC_010612.1 lipoprotein LppI 3645085 lppI 6227287 lppI Mycobacterium marinum M lipoprotein LppI YP_001851313.1 3644405 D 216594 CDS YP_001851314.1 183983023 6227288 3645417..3645734 1 NC_010612.1 hypothetical protein 3645734 6227288 MMAR_3022 Mycobacterium marinum M hypothetical protein YP_001851314.1 3645417 D 216594 CDS YP_001851315.1 183983024 6227289 3645738..3646601 1 NC_010612.1 hypothetical protein 3646601 6227289 MMAR_3023 Mycobacterium marinum M hypothetical protein YP_001851315.1 3645738 D 216594 CDS YP_001851316.1 183983025 6227290 complement(3646743..3649403) 1 NC_010612.1 hypothetical protein 3649403 6227290 MMAR_3024 Mycobacterium marinum M hypothetical protein YP_001851316.1 3646743 R 216594 CDS YP_001851317.1 183983026 6227291 complement(3649476..3662039) 1 NC_010612.1 required for mycoketide synthesis; polyketide synthase 3662039 pks12 6227291 pks12 Mycobacterium marinum M polyketide synthase YP_001851317.1 3649476 R 216594 CDS YP_001851318.1 183983027 6227292 complement(3662370..3662600) 1 NC_010612.1 hypothetical protein 3662600 6227292 MMAR_3026 Mycobacterium marinum M hypothetical protein YP_001851318.1 3662370 R 216594 CDS YP_001851319.1 183983028 6227293 3662916..3663221 1 NC_010612.1 hypothetical protein 3663221 6227293 MMAR_3027 Mycobacterium marinum M hypothetical protein YP_001851319.1 3662916 D 216594 CDS YP_001851320.1 183983029 6227294 complement(3663242..3664048) 1 NC_010612.1 transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates in mycobacterium tuberculosis; polyprenol-monophosphomannose synthase, Ppm1B 3664048 ppm1B 6227294 ppm1B Mycobacterium marinum M polyprenol-monophosphomannose synthase, Ppm1B YP_001851320.1 3663242 R 216594 CDS YP_001851321.1 183983030 6227295 complement(3664074..3666188) 1 NC_010612.1 transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates in mycobacterium tuberculosis; polyprenol-monophosphomannose synthase, Ppm1A 3666188 ppm1A 6227295 ppm1A Mycobacterium marinum M polyprenol-monophosphomannose synthase, Ppm1A YP_001851321.1 3664074 R 216594 CDS YP_001851322.1 183983031 6227296 complement(3666181..3667785) 1 NC_010612.1 domain identity with predicted metal-dependent hydrolases with the TIM-barrel folds; hypothetical protein 3667785 6227296 MMAR_3030 Mycobacterium marinum M hypothetical protein YP_001851322.1 3666181 R 216594 CDS YP_001851323.1 183983032 6227297 complement(3667816..3668448) 1 NC_010612.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 3668448 fxsA 6227297 fxsA Mycobacterium marinum M FxsA protein YP_001851323.1 3667816 R 216594 CDS YP_001851324.1 183983033 6227298 3668449..3669231 1 NC_010612.1 domain identity with dienelactone hydrolases; hypothetical protein 3669231 6227298 MMAR_3032 Mycobacterium marinum M hypothetical protein YP_001851324.1 3668449 D 216594 CDS YP_001851325.1 183983034 6227299 3669449..3671083 1 NC_010612.1 hypothetical protein 3671083 6227299 MMAR_3033 Mycobacterium marinum M hypothetical protein YP_001851325.1 3669449 D 216594 CDS YP_001851326.1 183983035 6227300 complement(3671108..3672799) 1 NC_010612.1 transmembrane protein 3672799 6227300 MMAR_3034 Mycobacterium marinum M transmembrane protein YP_001851326.1 3671108 R 216594 CDS YP_001851327.1 183983036 6227301 complement(3672840..3673718) 1 NC_010612.1 function unknown. domain identity to ThiJ-like intracellular proteases/amidases; hypothetical protein 3673718 6227301 MMAR_3035 Mycobacterium marinum M hypothetical protein YP_001851327.1 3672840 R 216594 CDS YP_001851328.1 183983037 6227302 complement(3673729..3674118) 1 NC_010612.1 hypothetical protein 3674118 6227302 MMAR_3036 Mycobacterium marinum M hypothetical protein YP_001851328.1 3673729 R 216594 CDS YP_001851329.1 183983038 6227303 complement(3674223..3677795) 1 NC_010612.1 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; cobaltochelatase subunit CobN 3677795 cobN 6227303 cobN Mycobacterium marinum M cobaltochelatase subunit CobN YP_001851329.1 3674223 R 216594 CDS YP_001851330.1 183983039 6227304 complement(3677788..3678009) 1 NC_010612.1 hypothetical protein 3678009 6227304 MMAR_3038 Mycobacterium marinum M hypothetical protein YP_001851330.1 3677788 R 216594 CDS YP_001851331.1 183983040 6227305 complement(3678056..3679597) 1 NC_010612.1 membrane-bound oxidoreductase 3679597 6227305 MMAR_3039 Mycobacterium marinum M membrane-bound oxidoreductase YP_001851331.1 3678056 R 216594 CDS YP_001851332.1 183983041 6227306 3679760..3680587 1 NC_010612.1 cellular metabolism; short chain dehydrogenase 3680587 6227306 MMAR_3040 Mycobacterium marinum M short chain dehydrogenase YP_001851332.1 3679760 D 216594 CDS YP_001851333.1 183983042 6227307 3680584..3681480 1 NC_010612.1 hypothetical protein 3681480 6227307 MMAR_3041 Mycobacterium marinum M hypothetical protein YP_001851333.1 3680584 D 216594 CDS YP_001851334.1 183983043 6227308 complement(3681566..3682312) 1 NC_010612.1 function unknown. contains adenylate cyclase domain; hypothetical protein 3682312 6227308 MMAR_3042 Mycobacterium marinum M hypothetical protein YP_001851334.1 3681566 R 216594 CDS YP_001851335.1 183983044 6227309 3682421..3685648 1 NC_010612.1 adenylate cyclase 3685648 6227309 MMAR_3043 Mycobacterium marinum M adenylate cyclase YP_001851335.1 3682421 D 216594 CDS YP_001851336.1 183983045 6227310 3685734..3686843 1 NC_010612.1 cobalamin biosynthesis protein 3686843 6227310 MMAR_3044 Mycobacterium marinum M cobalamin biosynthesis protein YP_001851336.1 3685734 D 216594 CDS YP_001851337.1 183983046 6227311 3686861..3687487 1 NC_010612.1 catalyzes the interconversion of precorrin-8X and hydrogenobyrinate; precorrin-8X methylmutase 3687487 cobH 6227311 cobH Mycobacterium marinum M precorrin-8X methylmutase YP_001851337.1 3686861 D 216594 CDS YP_001851338.1 183983047 6227312 3687484..3688953 1 NC_010612.1 involved in cobalamin biosynthesis; bifunctional cobalamin adenosyltransferase CobI/precorrin-3B C(17)-methyltransferase CobJ 3688953 cobI 6227312 cobI Mycobacterium marinum M bifunctional cobalamin adenosyltransferase CobI/precorrin-3B C(17)-methyltransferase CobJ YP_001851338.1 3687484 D 216594 CDS YP_001851339.1 183983048 6227313 complement(3688950..3690176) 1 NC_010612.1 hypothetical protein 3690176 6227313 MMAR_3047 Mycobacterium marinum M hypothetical protein YP_001851339.1 3688950 R 216594 CDS YP_001851340.1 183983049 6227314 complement(3690209..3693205) 1 NC_010612.1 thought to be involved in fatty acid transport; transmembrane transport protein MmpL 3693205 mmpL5_5 6227314 mmpL5_5 Mycobacterium marinum M transmembrane transport protein MmpL YP_001851340.1 3690209 R 216594 CDS YP_001851341.1 183983050 6227315 complement(3693202..3693633) 1 NC_010612.1 membrane transporter 3693633 mmpS4_1 6227315 mmpS4_1 Mycobacterium marinum M membrane transporter YP_001851341.1 3693202 R 216594 CDS YP_001851342.1 183983051 6227316 complement(3693985..3694920) 1 NC_010612.1 hydrolyses beta-lactams to generate corresponding beta-amino acid [catalytic activity: a beta-lactam + H(2)O = a substituted beta-amino acid]; class a beta-lactamase, BlaC 3694920 blaC 6227316 blaC Mycobacterium marinum M class a beta-lactamase, BlaC YP_001851342.1 3693985 R 216594 CDS YP_001851343.1 183983052 6227317 3695056..3695610 1 NC_010612.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigC 3695610 sigC 6227317 sigC Mycobacterium marinum M RNA polymerase sigma factor SigC YP_001851343.1 3695056 D 216594 CDS YP_001851344.1 183983053 6227318 complement(3695616..3696344) 1 NC_010612.1 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; cobalt-precorrin-6x reductase 3696344 cobK 6227318 cobK Mycobacterium marinum M cobalt-precorrin-6x reductase YP_001851344.1 3695616 R 216594 CDS YP_001851345.1 183983054 6227319 complement(3696341..3697090) 1 NC_010612.1 involved in cobalamin biosynthesis; precorrin-4 C11-methyltransferase, CobM 3697090 cobM 6227319 cobM Mycobacterium marinum M precorrin-4 C11-methyltransferase, CobM YP_001851345.1 3696341 R 216594 CDS YP_001851346.1 183983055 6227320 complement(3697087..3698259) 1 NC_010612.1 precorrin-6y methyltransferase, CobL 3698259 cobL 6227320 cobL Mycobacterium marinum M precorrin-6y methyltransferase, CobL YP_001851346.1 3697087 R 216594 CDS YP_001851347.1 183983056 6227321 complement(3698256..3699005) 1 NC_010612.1 short chain dehydrogenase 3699005 6227321 MMAR_3055 Mycobacterium marinum M short chain dehydrogenase YP_001851347.1 3698256 R 216594 CDS YP_001851348.1 183983057 6227322 3699041..3699451 1 NC_010612.1 hypothetical protein 3699451 6227322 MMAR_3056 Mycobacterium marinum M hypothetical protein YP_001851348.1 3699041 D 216594 CDS YP_001851349.1 183983058 6227324 complement(3699989..3701458) 1 NC_010612.1 hypothetical protein 3701458 6227324 MMAR_3058 Mycobacterium marinum M hypothetical protein YP_001851349.1 3699989 R 216594 CDS YP_001851350.1 183983059 6227325 complement(3701809..3702639) 1 NC_010612.1 hypothetical protein 3702639 6227325 MMAR_3059 Mycobacterium marinum M hypothetical protein YP_001851350.1 3701809 R 216594 CDS YP_001851351.1 183983060 6227326 complement(3702636..3703472) 1 NC_010612.1 hypothetical protein 3703472 6227326 MMAR_3060 Mycobacterium marinum M hypothetical protein YP_001851351.1 3702636 R 216594 CDS YP_001851352.1 183983061 6227327 complement(3703472..3705814) 1 NC_010612.1 hypothetical protein 3705814 6227327 MMAR_3061 Mycobacterium marinum M hypothetical protein YP_001851352.1 3703472 R 216594 CDS YP_001851353.1 183983062 6227329 3706957..3707499 1 NC_010612.1 hypothetical protein 3707499 6227329 MMAR_3063 Mycobacterium marinum M hypothetical protein YP_001851353.1 3706957 D 216594 CDS YP_001851354.1 183983063 6227330 3707486..3708001 1 NC_010612.1 hypothetical protein 3708001 6227330 MMAR_3064 Mycobacterium marinum M hypothetical protein YP_001851354.1 3707486 D 216594 CDS YP_001851355.1 183983064 6227331 3708649..3709188 1 NC_010612.1 hypothetical protein 3709188 6227331 MMAR_3065 Mycobacterium marinum M hypothetical protein YP_001851355.1 3708649 D 216594 CDS YP_001851356.1 183983065 6227332 3709178..3711334 1 NC_010612.1 hypothetical protein 3711334 6227332 MMAR_3066 Mycobacterium marinum M hypothetical protein YP_001851356.1 3709178 D 216594 CDS YP_001851357.1 183983066 6227333 3711331..3712299 1 NC_010612.1 hypothetical protein 3712299 6227333 MMAR_3067 Mycobacterium marinum M hypothetical protein YP_001851357.1 3711331 D 216594 CDS YP_001851358.1 183983067 6227334 complement(3712396..3715758) 1 NC_010612.1 hypothetical protein 3715758 6227334 MMAR_3068 Mycobacterium marinum M hypothetical protein YP_001851358.1 3712396 R 216594 CDS YP_001851359.1 183983068 6227335 complement(3715751..3716446) 1 NC_010612.1 hypothetical protein 3716446 6227335 MMAR_3069 Mycobacterium marinum M hypothetical protein YP_001851359.1 3715751 R 216594 CDS YP_001851360.1 183983069 6227336 complement(3716443..3717888) 1 NC_010612.1 hypothetical protein 3717888 6227336 MMAR_3070 Mycobacterium marinum M hypothetical protein YP_001851360.1 3716443 R 216594 CDS YP_001851361.1 183983070 6227337 complement(3718588..3718851) 1 NC_010612.1 hypothetical protein 3718851 6227337 MMAR_3071 Mycobacterium marinum M hypothetical protein YP_001851361.1 3718588 R 216594 CDS YP_001851362.1 183983071 6227338 complement(3718858..3721434) 1 NC_010612.1 hypothetical protein 3721434 6227338 MMAR_3072 Mycobacterium marinum M hypothetical protein YP_001851362.1 3718858 R 216594 CDS YP_001851363.1 183983072 6227339 3721551..3722114 1 NC_010612.1 hypothetical protein 3722114 6227339 MMAR_3073 Mycobacterium marinum M hypothetical protein YP_001851363.1 3721551 D 216594 CDS YP_001851364.1 183983073 6227340 complement(3722140..3724383) 1 NC_010612.1 hypothetical protein 3724383 6227340 MMAR_3074 Mycobacterium marinum M hypothetical protein YP_001851364.1 3722140 R 216594 CDS YP_001851365.1 183983074 6227341 complement(3724420..3725547) 1 NC_010612.1 hydrolysis of peptide bonds; dipeptidase PepE 3725547 pepE 6227341 pepE Mycobacterium marinum M dipeptidase PepE YP_001851365.1 3724420 R 216594 CDS YP_001851366.1 183983075 6227342 3725671..3726627 1 NC_010612.1 involved in DNA metabolism; 5'-3' exonuclease 3726627 6227342 MMAR_3076 Mycobacterium marinum M 5'-3' exonuclease YP_001851366.1 3725671 D 216594 CDS YP_001851367.1 183983076 6227343 complement(3726640..3727404) 1 NC_010612.1 hypothetical protein 3727404 6227343 MMAR_3077 Mycobacterium marinum M hypothetical protein YP_001851367.1 3726640 R 216594 CDS YP_001851368.1 183983077 6227344 complement(3727511..3730267) 1 NC_010612.1 DNA helicase activity; ATP-dependent DNA helicase HelY 3730267 helY 6227344 helY Mycobacterium marinum M ATP-dependent DNA helicase HelY YP_001851368.1 3727511 R 216594 CDS YP_001851369.1 183983078 6227345 complement(3730355..3731308) 1 NC_010612.1 involved in proteins export: required for correct localization of precursor proteins bearing signal peptides with the twin arginine conserved motif S/T-R-R-X-F-L-K. this sec-independent pathway is termed tat for twin- arginine translocation system; sec-independent protein translocase transmembrane protein TatC 3731308 tatC 6227345 tatC Mycobacterium marinum M sec-independent protein translocase transmembrane protein TatC YP_001851369.1 3730355 R 216594 CDS YP_001851370.1 183983079 6227346 complement(3731351..3731617) 1 NC_010612.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 3731617 tatA 6227346 tatA Mycobacterium marinum M twin arginine translocase protein A YP_001851370.1 3731351 R 216594 CDS YP_001851371.1 183983080 6227347 complement(3731744..3732712) 1 NC_010612.1 hypothetical protein 3732712 6227347 MMAR_3081 Mycobacterium marinum M hypothetical protein YP_001851371.1 3731744 R 216594 CDS YP_001851372.1 183983081 6227348 complement(3732762..3733760) 1 NC_010612.1 contains domain homology to transcriptional regulators; hypothetical protein 3733760 6227348 MMAR_3082 Mycobacterium marinum M hypothetical protein YP_001851372.1 3732762 R 216594 CDS YP_001851373.1 183983082 6227349 complement(3733814..3735172) 1 NC_010612.1 hypothetical protein 3735172 6227349 MMAR_3083 Mycobacterium marinum M hypothetical protein YP_001851373.1 3733814 R 216594 CDS YP_001851374.1 183983083 6227350 complement(3735230..3736033) 1 NC_010612.1 protein degradation; proteasome PrcA 3736033 prcA 6227350 prcA Mycobacterium marinum M proteasome PrcA YP_001851374.1 3735230 R 216594 CDS YP_001851375.1 183983084 6227351 complement(3736030..3736899) 1 NC_010612.1 protein degradation; proteasome PrcB 3736899 prcB 6227351 prcB Mycobacterium marinum M proteasome PrcB YP_001851375.1 3736030 R 216594 CDS YP_001851376.1 183983085 6227352 complement(3736896..3737090) 1 NC_010612.1 hypothetical protein 3737090 6227352 MMAR_3086 Mycobacterium marinum M hypothetical protein YP_001851376.1 3736896 R 216594 CDS YP_001851377.1 183983086 6227353 complement(3737262..3738770) 1 NC_010612.1 hypothetical protein 3738770 6227353 MMAR_3087 Mycobacterium marinum M hypothetical protein YP_001851377.1 3737262 R 216594 CDS YP_001851378.1 183983087 6227354 3739067..3740341 1 NC_010612.1 hypothetical protein 3740341 6227354 MMAR_3088 Mycobacterium marinum M hypothetical protein YP_001851378.1 3739067 D 216594 CDS YP_001851379.1 183983088 6227355 3740382..3741566 1 NC_010612.1 integral membrane protein 3741566 6227355 MMAR_3089 Mycobacterium marinum M integral membrane protein YP_001851379.1 3740382 D 216594 CDS YP_001851380.1 183983089 6227356 3741538..3742200 1 NC_010612.1 hypothetical protein 3742200 6227356 MMAR_3090 Mycobacterium marinum M hypothetical protein YP_001851380.1 3741538 D 216594 CDS YP_001851381.1 183983090 6227357 complement(3742222..3744051) 1 NC_010612.1 ATPase 3744051 6227357 MMAR_3091 Mycobacterium marinum M ATPase YP_001851381.1 3742222 R 216594 CDS YP_001851382.1 183983091 6227358 3744367..3745008 1 NC_010612.1 lipoprotein LppK 3745008 lppK 6227358 lppK Mycobacterium marinum M lipoprotein LppK YP_001851382.1 3744367 D 216594 CDS YP_001851383.1 183983092 6227359 3745017..3745319 1 NC_010612.1 hypothetical protein 3745319 6227359 MMAR_3093 Mycobacterium marinum M hypothetical protein YP_001851383.1 3745017 D 216594 CDS YP_001851384.1 183983093 6227360 complement(3745332..3746174) 1 NC_010612.1 involved in transfer of methyl group (from S- adenosyl-L-methionine to a substrate); RNA methyltransferase 3746174 6227360 MMAR_3094 Mycobacterium marinum M RNA methyltransferase YP_001851384.1 3745332 R 216594 CDS YP_001851385.1 183983094 6227361 3746248..3747129 1 NC_010612.1 has significant domain identity to RecB family exonucleases; hypothetical protein 3747129 6227361 MMAR_3095 Mycobacterium marinum M hypothetical protein YP_001851385.1 3746248 D 216594 CDS YP_001851386.1 183983095 6227362 3747126..3747905 1 NC_010612.1 hypothetical protein 3747905 6227362 MMAR_3096 Mycobacterium marinum M hypothetical protein YP_001851386.1 3747126 D 216594 CDS YP_001851387.1 183983096 6227363 complement(3747926..3764707) 1 NC_010612.1 Nrp of 5 modules. domain structure (C, a, T) X 5, ending in a te domain. metabolite produced unknown; non-ribosomal peptide synthetase 3764707 6227363 MMAR_3097 Mycobacterium marinum M non-ribosomal peptide synthetase YP_001851387.1 3747926 R 216594 CDS YP_001851388.1 183983097 6227364 complement(3764826..3772826) 1 NC_010612.1 a single module PKS, with the following domain structure when linked with U/S and D/S ORFs: (KS, ATProp, DH, ER, KR, ACP); polyketide synthase 3772826 6227364 MMAR_3098 Mycobacterium marinum M polyketide synthase YP_001851388.1 3764826 R 216594 CDS YP_001851389.1 183983098 6227365 complement(3772823..3781318) 1 NC_010612.1 production of unknown metabolite. this CDS encodes a single NRP and PKS module with domain structure: (KS, Ata, DH, ER, KR, ACP); polyketide synthase and peptide synthetase 3781318 6227365 MMAR_3099 Mycobacterium marinum M polyketide synthase and peptide synthetase YP_001851389.1 3772823 R 216594 CDS YP_001851390.1 183983099 6227366 3781744..3783345 1 NC_010612.1 translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; integral membrane drug efflux protein, ErmB 3783345 ermB_1 6227366 ermB_1 Mycobacterium marinum M integral membrane drug efflux protein, ErmB YP_001851390.1 3781744 D 216594 CDS YP_001851391.1 183983100 6227367 complement(3783385..3784764) 1 NC_010612.1 Enables the enzymatic reduction of mercuric ions to elemental mercury; mercuric reductase 3784764 lpd_1 6227367 lpd_1 Mycobacterium marinum M mercuric reductase YP_001851391.1 3783385 R 216594 CDS YP_001851392.1 183983101 6227368 complement(3784761..3785243) 1 NC_010612.1 hypothetical protein 3785243 6227368 MMAR_3102 Mycobacterium marinum M hypothetical protein YP_001851392.1 3784761 R 216594 CDS YP_001851393.1 183983102 6227369 complement(3785360..3786220) 1 NC_010612.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 3786220 hisG 6227369 hisG Mycobacterium marinum M ATP phosphoribosyltransferase YP_001851393.1 3785360 R 216594 CDS YP_001851394.1 183983103 6227370 complement(3786217..3786498) 1 NC_010612.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase 3786498 hisE 6227370 hisE Mycobacterium marinum M phosphoribosyl-ATP pyrophosphatase YP_001851394.1 3786217 R 216594 CDS YP_001851395.1 183983104 6227371 complement(3786617..3788968) 1 NC_010612.1 PE-PGRS family protein 3788968 6227371 MMAR_3105 Mycobacterium marinum M PE-PGRS family protein YP_001851395.1 3786617 R 216594 CDS YP_001851396.1 183983105 6227372 3789361..3790800 1 NC_010612.1 PPE family protein 3790800 6227372 MMAR_3106 Mycobacterium marinum M PPE family protein YP_001851396.1 3789361 D 216594 CDS YP_001851397.1 183983106 6227373 3791355..3792233 1 NC_010612.1 hypothetical protein 3792233 6227373 MMAR_3107 Mycobacterium marinum M hypothetical protein YP_001851397.1 3791355 D 216594 CDS YP_001851398.1 183983107 6227374 complement(3792283..3793488) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; FAD-dependent oxidoreductase 3793488 6227374 MMAR_3108 Mycobacterium marinum M FAD-dependent oxidoreductase YP_001851398.1 3792283 R 216594 CDS YP_001851399.1 183983108 6227375 complement(3793528..3794409) 1 NC_010612.1 short chain dehydrogenase 3794409 6227375 MMAR_3109 Mycobacterium marinum M short chain dehydrogenase YP_001851399.1 3793528 R 216594 CDS YP_001851400.1 183983109 6227376 complement(3794433..3795668) 1 NC_010612.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 3795668 mshC 6227376 mshC Mycobacterium marinum M cysteinyl-tRNA synthetase YP_001851400.1 3794433 R 216594 CDS YP_001851401.1 183983110 6227377 3795871..3797487 1 NC_010612.1 involved in 4-aminobutyrate (GabA) degradation pathway [catalytic activity: succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H]; succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 3797487 gabD1_1 6227377 gabD1_1 Mycobacterium marinum M succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 YP_001851401.1 3795871 D 216594 CDS YP_001851402.1 183983111 6227378 complement(3797516..3798307) 1 NC_010612.1 may help control the pool of 3'-PHOSPHOADENOSIDE 5'- phosphosulfate, or its use in sulfite synthesis (by similarity); monophosphatase CysQ 3798307 cysQ 6227378 cysQ Mycobacterium marinum M monophosphatase CysQ YP_001851402.1 3797516 R 216594 CDS YP_001851403.1 183983112 6227379 complement(3798419..3799234) 1 NC_010612.1 hypothetical protein 3799234 6227379 MMAR_3113 Mycobacterium marinum M hypothetical protein YP_001851403.1 3798419 R 216594 CDS YP_001851404.1 183983113 6227380 complement(3799218..3799805) 1 NC_010612.1 hypothetical protein 3799805 6227380 MMAR_3114 Mycobacterium marinum M hypothetical protein YP_001851404.1 3799218 R 216594 CDS YP_001851405.1 183983114 6227381 complement(3799894..3800640) 1 NC_010612.1 hypothetical protein 3800640 6227381 MMAR_3115 Mycobacterium marinum M hypothetical protein YP_001851405.1 3799894 R 216594 CDS YP_001851406.1 183983115 6227382 complement(3800637..3801485) 1 NC_010612.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 3801485 6227382 MMAR_3116 Mycobacterium marinum M undecaprenyl pyrophosphate phosphatase YP_001851406.1 3800637 R 216594 CDS YP_001851407.1 183983116 6227383 complement(3801529..3801831) 1 NC_010612.1 hypothetical protein 3801831 6227383 MMAR_3117 Mycobacterium marinum M hypothetical protein YP_001851407.1 3801529 R 216594 CDS YP_001851408.1 183983117 6227384 3801942..3803012 1 NC_010612.1 lipoprotein LppL 3803012 lppL 6227384 lppL Mycobacterium marinum M lipoprotein LppL YP_001851408.1 3801942 D 216594 CDS YP_001851409.1 183983118 6227385 3803009..3803272 1 NC_010612.1 hypothetical protein 3803272 6227385 MMAR_3119 Mycobacterium marinum M hypothetical protein YP_001851409.1 3803009 D 216594 CDS YP_001851410.1 183983119 6227386 3803305..3804387 1 NC_010612.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 3804387 pyrD 6227386 pyrD Mycobacterium marinum M dihydroorotate dehydrogenase 2 YP_001851410.1 3803305 D 216594 CDS YP_001851411.1 183983120 6227387 complement(3804399..3805787) 1 NC_010612.1 hypothetical protein 3805787 6227387 MMAR_3121 Mycobacterium marinum M hypothetical protein YP_001851411.1 3804399 R 216594 CDS YP_001851412.1 183983121 6227388 complement(3805913..3806440) 1 NC_010612.1 function unknown but contains bacterial/archael phosphatidylethanolamine-binding (PEBP) domain; hypothetical protein 3806440 6227388 MMAR_3122 Mycobacterium marinum M hypothetical protein YP_001851412.1 3805913 R 216594 CDS YP_001851413.1 183983122 6227389 complement(3806467..3807822) 1 NC_010612.1 function unknown - but has domain identity with cetylornithine deacetylase/succinyl-diaminopimelate desuccinylase and related deacylases [amino acid transport and metabolism]; hypothetical protein 3807822 6227389 MMAR_3123 Mycobacterium marinum M hypothetical protein YP_001851413.1 3806467 R 216594 CDS YP_001851414.1 183983123 6227391 complement(3808039..3809685) 1 NC_010612.1 site-specific integration of bacteriophage DNA; integrase 3809685 6227391 MMAR_3124 Mycobacterium marinum M integrase YP_001851414.1 3808039 R 216594 CDS YP_001851415.1 183983124 6227392 complement(3809872..3811377) 1 NC_010612.1 function unknown, signficant identity with putative plasmid replication initiator protein [streptomyces coelicolor A3(2)]; hypothetical protein 3811377 6227392 MMAR_3125 Mycobacterium marinum M hypothetical protein YP_001851415.1 3809872 R 216594 CDS YP_001851416.1 183983125 6227393 complement(3811374..3812807) 1 NC_010612.1 possible role in phage DNA replication. the FtsK/SpoIIIE family contains a putative ATP binding P-loop motif. it is found in the FtsK cell division protein from E. coli and the stage III sporulation protein E SpoIIIE, which has roles in regulation of prespore specific gene expression in B. subtilis. a mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification. the SpoIIIE protein is implicated in intercellular chromosomal DNA transfer; FtsK/SpoIIIE family protein 3812807 6227393 MMAR_3126 Mycobacterium marinum M FtsK/SpoIIIE family protein YP_001851416.1 3811374 R 216594 CDS YP_001851417.1 183983126 6227394 complement(3812897..3813241) 1 NC_010612.1 putative regulatory protein 3813241 6227394 MMAR_3127 Mycobacterium marinum M putative regulatory protein YP_001851417.1 3812897 R 216594 CDS YP_001851418.1 183983127 6227395 3813481..3814299 1 NC_010612.1 hypothetical protein 3814299 6227395 MMAR_3128 Mycobacterium marinum M hypothetical protein YP_001851418.1 3813481 D 216594 CDS YP_001851419.1 183983128 6227396 3814305..3814772 1 NC_010612.1 may be an ADP-ribose pyrophosphatase - involved DNA replication, recombination, and repair; hypothetical protein 3814772 6227396 MMAR_3129 Mycobacterium marinum M hypothetical protein YP_001851419.1 3814305 D 216594 CDS YP_001851420.1 183983129 6227397 complement(3814783..3815319) 1 NC_010612.1 hydrolase 3815319 6227397 MMAR_3130 Mycobacterium marinum M hydrolase YP_001851420.1 3814783 R 216594 CDS YP_001851421.1 183983130 6227399 complement(3816292..3817437) 1 NC_010612.1 function unknown, reaction: catalysis of the alpha,beta dehydrogenation of the corresponding trans- enoyl-CoA; acyl-CoA dehydrogenase 3817437 6227399 MMAR_3132 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001851421.1 3816292 R 216594 CDS YP_001851422.1 183983131 6227400 complement(3817480..3819093) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 3819093 fadD14_1 6227400 fadD14_1 Mycobacterium marinum M long-chain-fatty-acid--CoA ligase YP_001851422.1 3817480 R 216594 CDS YP_001851423.1 183983132 6227401 complement(3819120..3819773) 1 NC_010612.1 function unknown, contains a transglutaminase/protease-like domain; transglutaminases are enzymes that establish covalent links between proteins; hypothetical protein 3819773 6227401 MMAR_3134 Mycobacterium marinum M hypothetical protein YP_001851423.1 3819120 R 216594 CDS YP_001851424.1 183983133 6227402 complement(3819770..3821227) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 136B2 Cyp136B2 3821227 cyp136B2 6227402 cyp136B2 Mycobacterium marinum M cytochrome P450 136B2 Cyp136B2 YP_001851424.1 3819770 R 216594 CDS YP_001851425.1 183983134 6227403 complement(3821343..3822878) 1 NC_010612.1 function unknown; probably involved in cellular metabolism; monooxygenase 3822878 6227403 MMAR_3136 Mycobacterium marinum M monooxygenase YP_001851425.1 3821343 R 216594 CDS YP_001851426.1 183983135 6227404 complement(3822940..3823905) 1 NC_010612.1 function unknown role in lipid metabolism; esterase/lipase 3823905 6227404 MMAR_3137 Mycobacterium marinum M esterase/lipase YP_001851426.1 3822940 R 216594 CDS YP_001851427.1 183983136 6227405 complement(3823902..3825419) 1 NC_010612.1 function unknown; probably involved in cellular metabolism; monooxygenase 3825419 6227405 MMAR_3138 Mycobacterium marinum M monooxygenase YP_001851427.1 3823902 R 216594 CDS YP_001851428.1 183983137 6227406 complement(3825467..3826966) 1 NC_010612.1 function unknown; involved in cellular metabolism; monooxygenase 3826966 6227406 MMAR_3139 Mycobacterium marinum M monooxygenase YP_001851428.1 3825467 R 216594 CDS YP_001851429.1 183983138 6227407 complement(3826963..3827886) 1 NC_010612.1 hypothetical protein 3827886 6227407 MMAR_3140 Mycobacterium marinum M hypothetical protein YP_001851429.1 3826963 R 216594 CDS YP_001851430.1 183983139 6227408 complement(3827888..3828754) 1 NC_010612.1 short-chain membrane-associated dehydrogenase 3828754 6227408 MMAR_3141 Mycobacterium marinum M short-chain membrane-associated dehydrogenase YP_001851430.1 3827888 R 216594 CDS YP_001851431.1 183983140 6227409 3828875..3829516 1 NC_010612.1 could be involved in transcriptional mechanism; TetR family transcriptional regulator 3829516 6227409 MMAR_3142 Mycobacterium marinum M TetR family transcriptional regulator YP_001851431.1 3828875 D 216594 CDS YP_001851432.1 183983141 6227410 complement(3829683..3830552) 1 NC_010612.1 function unknown; contains hydrolase domain; hypothetical protein 3830552 6227410 MMAR_3143 Mycobacterium marinum M hypothetical protein YP_001851432.1 3829683 R 216594 CDS YP_001851433.1 183983142 6227411 3830626..3831315 1 NC_010612.1 could be involved in transcriptional mechanism; AcrR family transcriptional regulator 3831315 6227411 MMAR_3144 Mycobacterium marinum M AcrR family transcriptional regulator YP_001851433.1 3830626 D 216594 CDS YP_001851434.1 183983143 6227412 complement(3831478..3831786) 1 NC_010612.1 hypothetical protein 3831786 6227412 MMAR_3145 Mycobacterium marinum M hypothetical protein YP_001851434.1 3831478 R 216594 CDS YP_001851435.1 183983144 6227413 3831823..3832107 1 NC_010612.1 hypothetical protein 3832107 6227413 MMAR_3146 Mycobacterium marinum M hypothetical protein YP_001851435.1 3831823 D 216594 CDS YP_001851436.1 183983145 6227414 complement(3832443..3833525) 1 NC_010612.1 hypothetical protein 3833525 6227414 MMAR_3147 Mycobacterium marinum M hypothetical protein YP_001851436.1 3832443 R 216594 CDS YP_001851437.1 183983146 6227415 complement(3833522..3834316) 1 NC_010612.1 transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa2 3834316 6227415 MMAR_3148 Mycobacterium marinum M transposase, ISMyma01_aa2 YP_001851437.1 3833522 R 216594 CDS YP_001851438.1 183983147 6227416 complement(3834358..3834639) 1 NC_010612.1 transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa1 3834639 6227416 MMAR_3149 Mycobacterium marinum M transposase, ISMyma01_aa1 YP_001851438.1 3834358 R 216594 CDS YP_001851439.1 183983148 6227417 complement(3835065..3836171) 1 NC_010612.1 thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]; zinc-containing alcohol dehydrogenase NAD- dependent 3836171 6227417 MMAR_3150 Mycobacterium marinum M zinc-containing alcohol dehydrogenase NAD- dependent YP_001851439.1 3835065 R 216594 CDS YP_001851440.1 183983149 6227418 complement(3836218..3837846) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 3837846 6227418 MMAR_3151 Mycobacterium marinum M long-chain-fatty-acid--CoA ligase YP_001851440.1 3836218 R 216594 CDS YP_001851441.1 183983150 6227419 complement(3837883..3838305) 1 NC_010612.1 hypothetical protein 3838305 6227419 MMAR_3152 Mycobacterium marinum M hypothetical protein YP_001851441.1 3837883 R 216594 CDS YP_001851442.1 183983151 6227420 complement(3838555..3839757) 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin reductase 3839757 6227420 MMAR_3153 Mycobacterium marinum M ferredoxin reductase YP_001851442.1 3838555 R 216594 CDS YP_001851443.1 183983152 6227421 complement(3839754..3841145) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 153A16 Cyp153A16 3841145 cyp153A16 6227421 cyp153A16 Mycobacterium marinum M cytochrome P450 153A16 Cyp153A16 YP_001851443.1 3839754 R 216594 CDS YP_001851444.1 183983153 6227422 complement(3841166..3841486) 1 NC_010612.1 involved in electron transfer and energy coupling reactions. probably part of an operon including the P450 and ferrodoxin reductase gene products; ferredoxin 3841486 6227422 MMAR_3155 Mycobacterium marinum M ferredoxin YP_001851444.1 3841166 R 216594 CDS YP_001851445.1 183983154 6227423 3841604..3842614 1 NC_010612.1 involved in transcriptional mechanism; AraC/XylS family transcriptional regulator 3842614 6227423 MMAR_3156 Mycobacterium marinum M AraC/XylS family transcriptional regulator YP_001851445.1 3841604 D 216594 CDS YP_001851446.1 183983155 6227425 complement(3843257..3843874) 1 NC_010612.1 probably involved in a transcriptional mechanism; TetR family transcriptional regulator 3843874 6227425 MMAR_3158 Mycobacterium marinum M TetR family transcriptional regulator YP_001851446.1 3843257 R 216594 CDS YP_001851447.1 183983156 6227426 complement(3843928..3844839) 1 NC_010612.1 function unknown; contains predicted hydrolase or acyltransferase domain (alpha/beta hydrolase superfamily; hydrolase 3844839 6227426 MMAR_3159 Mycobacterium marinum M hydrolase YP_001851447.1 3843928 R 216594 CDS YP_001851448.1 183983157 6227427 complement(3844839..3845282) 1 NC_010612.1 function unknown; hypothetical protein 3845282 6227427 MMAR_3160 Mycobacterium marinum M hypothetical protein YP_001851448.1 3844839 R 216594 CDS YP_001851449.1 183983158 6227428 complement(3845330..3845944) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 3845944 6227428 MMAR_3161 Mycobacterium marinum M transcriptional regulatory protein YP_001851449.1 3845330 R 216594 CDS YP_001851450.1 183983159 6227429 3846064..3846498 1 NC_010612.1 function unknown but contains domain identity with acetyl-CoA acetyltransferase domain, thus possible involvement in lipid metabolism; hypothetical protein 3846498 6227429 MMAR_3162 Mycobacterium marinum M hypothetical protein YP_001851450.1 3846064 D 216594 CDS YP_001851451.1 183983160 6227430 3846495..3847667 1 NC_010612.1 Zn-dependent alcohol dehydrogenase 3847667 6227430 MMAR_3163 Mycobacterium marinum M Zn-dependent alcohol dehydrogenase YP_001851451.1 3846495 D 216594 CDS YP_001851452.1 183983161 6227431 3847630..3848208 1 NC_010612.1 hypothetical protein 3848208 6227431 MMAR_3164 Mycobacterium marinum M hypothetical protein YP_001851452.1 3847630 D 216594 CDS YP_001851453.1 183983162 6227432 complement(3848464..3848727) 1 NC_010612.1 hypothetical protein 3848727 6227432 MMAR_3165 Mycobacterium marinum M hypothetical protein YP_001851453.1 3848464 R 216594 CDS YP_001851454.1 183983163 6227433 3849153..3849587 1 NC_010612.1 function unknown; contains DNA-binding domain; hypothetical protein 3849587 6227433 MMAR_3166 Mycobacterium marinum M hypothetical protein YP_001851454.1 3849153 D 216594 CDS YP_001851455.1 183983164 6227436 3852426..3852671 1 NC_010612.1 hypothetical protein 3852671 6227436 MMAR_5567 Mycobacterium marinum M hypothetical protein YP_001851455.1 3852426 D 216594 CDS YP_001851456.1 183983165 6227437 complement(3852808..3853623) 1 NC_010612.1 orthologue in M. tuberculosis H37Rv has been shown to catalyze the transfer of a methyl group onto the lipid moiety of phthiotriol dimycocerosates to form dim; methyltransferase 3853623 6227437 MMAR_3170 Mycobacterium marinum M methyltransferase YP_001851456.1 3852808 R 216594 CDS YP_001851457.1 183983166 6227439 complement(3854135..3854365) 1 NC_010612.1 hypothetical protein 3854365 6227439 MMAR_5571 Mycobacterium marinum M hypothetical protein YP_001851457.1 3854135 R 216594 CDS YP_001851458.1 183983167 6227441 complement(3855233..3855463) 1 NC_010612.1 thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins; protein MbtH 3855463 mbtH 6227441 mbtH Mycobacterium marinum M protein MbtH YP_001851458.1 3855233 R 216594 CDS YP_001851459.1 183983168 6227442 complement(3855755..3858613) 1 NC_010612.1 function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL 3858613 mmpL4_5 6227442 mmpL4_5 Mycobacterium marinum M transmembrane transport protein MmpL YP_001851459.1 3855755 R 216594 CDS YP_001851460.1 183983169 6227443 complement(3858610..3859008) 1 NC_010612.1 membrane protein MmpS4 3859008 mmpS4 6227443 mmpS4 Mycobacterium marinum M membrane protein MmpS4 YP_001851460.1 3858610 R 216594 CDS YP_001851461.1 183983170 6227444 complement(3859153..3879816) 1 NC_010612.1 production of unknown peptide. contains 5 predicted modules of domain organiszation:Amt, CAMT, cat, cat, CAMT int te. the 'A' domain substrates have not been accurately predicted but probably Phe, Thr or ala); non-ribosomal peptide synthetase 3879816 6227444 MMAR_3176 Mycobacterium marinum M non-ribosomal peptide synthetase YP_001851461.1 3859153 R 216594 CDS YP_001851462.1 183983171 6227445 complement(3879856..3880305) 1 NC_010612.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 3880305 panD_2 6227445 panD_2 Mycobacterium marinum M aspartate alpha-decarboxylase YP_001851462.1 3879856 R 216594 CDS YP_001851463.1 183983172 6227449 3882359..3883300 1 NC_010612.1 function unknown but contains lysophospholipase domain; hypothetical protein 3883300 6227449 MMAR_3182 Mycobacterium marinum M hypothetical protein YP_001851463.1 3882359 D 216594 CDS YP_001851464.1 183983173 6227450 3883446..3884012 1 NC_010612.1 hypothetical protein 3884012 6227450 MMAR_3183 Mycobacterium marinum M hypothetical protein YP_001851464.1 3883446 D 216594 CDS YP_001851465.1 183983174 6227451 complement(3884113..3884514) 1 NC_010612.1 hypothetical protein 3884514 6227451 MMAR_3184 Mycobacterium marinum M hypothetical protein YP_001851465.1 3884113 R 216594 CDS YP_001851466.1 183983175 6227452 complement(3884599..3885393) 1 NC_010612.1 function unknown but corresponds to antigen 84 of mycobacterium tuberculosis (Wag31) (see hermans et al., 1995). predicted to contain significant amount of coiled coil structure; secreted antigen Wag31 3885393 wag31 6227452 wag31 Mycobacterium marinum M secreted antigen Wag31 YP_001851466.1 3884599 R 216594 CDS YP_001851467.1 183983176 6227453 complement(3885650..3885937) 1 NC_010612.1 hypothetical protein 3885937 6227453 MMAR_3186 Mycobacterium marinum M hypothetical protein YP_001851467.1 3885650 R 216594 CDS YP_001851468.1 183983177 6227454 complement(3886118..3886789) 1 NC_010612.1 hypothetical protein 3886789 6227454 MMAR_3187 Mycobacterium marinum M hypothetical protein YP_001851468.1 3886118 R 216594 CDS YP_001851469.1 183983178 6227455 complement(3886854..3887639) 1 NC_010612.1 hypothetical protein 3887639 6227455 MMAR_3188 Mycobacterium marinum M hypothetical protein YP_001851469.1 3886854 R 216594 CDS YP_001851470.1 183983179 6227456 complement(3887636..3888424) 1 NC_010612.1 membrane protein YfiH 3888424 yfiH 6227456 yfiH Mycobacterium marinum M membrane protein YfiH YP_001851470.1 3887636 R 216594 CDS YP_001851471.1 183983180 6227457 complement(3888435..3889595) 1 NC_010612.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 3889595 ftsZ 6227457 ftsZ Mycobacterium marinum M cell division protein FtsZ YP_001851471.1 3888435 R 216594 CDS YP_001851472.1 183983181 6227458 complement(3889845..3890801) 1 NC_010612.1 this protein may be involved in septum formation (by similarity); cell division protein FtsQ 3890801 ftsQ 6227458 ftsQ Mycobacterium marinum M cell division protein FtsQ YP_001851472.1 3889845 R 216594 CDS YP_001851473.1 183983182 6227459 complement(3890798..3892264) 1 NC_010612.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 3892264 murC 6227459 murC Mycobacterium marinum M UDP-N-acetylmuramate--L-alanine ligase YP_001851473.1 3890798 R 216594 CDS YP_001851474.1 183983183 6227460 complement(3892261..3893460) 1 NC_010612.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 3893460 murG 6227460 murG Mycobacterium marinum M undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_001851474.1 3892261 R 216594 CDS YP_001851475.1 183983184 6227461 complement(3893457..3895088) 1 NC_010612.1 function unknown function in cell division; FtsW-like protein FtsW 3895088 ftsW 6227461 ftsW Mycobacterium marinum M FtsW-like protein FtsW YP_001851475.1 3893457 R 216594 CDS YP_001851476.1 183983185 6227462 complement(3895095..3896561) 1 NC_010612.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 3896561 murD 6227462 murD Mycobacterium marinum M UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_001851476.1 3895095 R 216594 CDS YP_001851477.1 183983186 6227463 complement(3896563..3897642) 1 NC_010612.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 3897642 mraY 6227463 mraY Mycobacterium marinum M phospho-N-acetylmuramoyl-pentapeptide- transferase YP_001851477.1 3896563 R 216594 CDS YP_001851478.1 183983187 6227464 complement(3897639..3899216) 1 NC_010612.1 involved in cell wall formation; peptidoglycan biosynthesis; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase MurF 3899216 murF 6227464 murF Mycobacterium marinum M UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase MurF YP_001851478.1 3897639 R 216594 CDS YP_001851479.1 183983188 6227465 complement(3899213..3900778) 1 NC_010612.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 3900778 murE 6227465 murE Mycobacterium marinum M UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_001851479.1 3899213 R 216594 CDS YP_001851480.1 183983189 6227466 complement(3901182..3902975) 1 NC_010612.1 PE-PGRS family protein 3902975 6227466 MMAR_3199 Mycobacterium marinum M PE-PGRS family protein YP_001851480.1 3901182 R 216594 CDS YP_001851481.1 183983190 6227467 complement(3903227..3905302) 1 NC_010612.1 involved in peptidoglycan biosynthesis; penicillin-binding membrane protein PbpB 3905302 pbpB 6227467 pbpB Mycobacterium marinum M penicillin-binding membrane protein PbpB YP_001851481.1 3903227 R 216594 CDS YP_001851482.1 183983191 6227468 complement(3905299..3906576) 1 NC_010612.1 proline rich membrane protein 3906576 6227468 MMAR_3201 Mycobacterium marinum M proline rich membrane protein YP_001851482.1 3905299 R 216594 CDS YP_001851483.1 183983192 6227469 complement(3906573..3907610) 1 NC_010612.1 S-adenosyl-methyltransferase MraW 3907610 mraW 6227469 mraW Mycobacterium marinum M S-adenosyl-methyltransferase MraW YP_001851483.1 3906573 R 216594 CDS YP_001851484.1 183983193 6227470 complement(3907762..3908217) 1 NC_010612.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 3908217 6227470 MMAR_3203 Mycobacterium marinum M cell division protein MraZ YP_001851484.1 3907762 R 216594 CDS YP_001851485.1 183983194 6227471 complement(3908602..3909006) 1 NC_010612.1 hypothetical protein 3909006 6227471 MMAR_3204 Mycobacterium marinum M hypothetical protein YP_001851485.1 3908602 R 216594 CDS YP_001851486.1 183983195 6227472 3909309..3909947 1 NC_010612.1 function unknown but contains acyl-CoA N- acyltransferase superfamily domain; hypothetical protein 3909947 6227472 MMAR_3205 Mycobacterium marinum M hypothetical protein YP_001851486.1 3909309 D 216594 CDS YP_001851487.1 183983196 6227473 3910016..3910744 1 NC_010612.1 lipoprotein LppM 3910744 lppM 6227473 lppM Mycobacterium marinum M lipoprotein LppM YP_001851487.1 3910016 D 216594 CDS YP_001851488.1 183983197 6227474 complement(3910790..3911686) 1 NC_010612.1 hypothetical protein 3911686 6227474 MMAR_3207 Mycobacterium marinum M hypothetical protein YP_001851488.1 3910790 R 216594 CDS YP_001851489.1 183983198 6227475 3912008..3913030 1 NC_010612.1 involved in lipid biosynthesis; geranylgeranyl pyrophosphate synthase 3913030 idsA2 6227475 idsA2 Mycobacterium marinum M geranylgeranyl pyrophosphate synthase YP_001851489.1 3912008 D 216594 CDS YP_001851490.1 183983199 6227476 3913035..3914615 1 NC_010612.1 hypothetical protein 3914615 6227476 MMAR_3209 Mycobacterium marinum M hypothetical protein YP_001851490.1 3913035 D 216594 CDS YP_001851491.1 183983200 6227477 complement(3914653..3915057) 1 NC_010612.1 regulatory protein 3915057 6227477 MMAR_3210 Mycobacterium marinum M regulatory protein YP_001851491.1 3914653 R 216594 CDS YP_001851492.1 183983201 6227478 3915148..3916443 1 NC_010612.1 involved in signal transduction (via phosphorylation); Ser/Thr protein kinase 3916443 pknL 6227478 pknL Mycobacterium marinum M Ser/Thr protein kinase YP_001851492.1 3915148 D 216594 CDS YP_001851493.1 183983202 6227479 complement(3916508..3917545) 1 NC_010612.1 involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (IPP, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths; polyprenyl synthetase IdsB_2 3917545 idsB_2 6227479 idsB_2 Mycobacterium marinum M polyprenyl synthetase IdsB_2 YP_001851493.1 3916508 R 216594 CDS YP_001851494.1 183983203 6227480 complement(3917562..3918728) 1 NC_010612.1 part of the mevalonate pathway for isoprenoid synthesis: conversion: acetyl-CoA + H(2)O + acetoacetyl- CoA <=> (S)-3-hydroxy-3-methylglutaryl-CoA + CoA; hydroxymethylglutaryl-coenzyme A synthase, PksG 3918728 pksG 6227480 pksG Mycobacterium marinum M hydroxymethylglutaryl-coenzyme A synthase, PksG YP_001851494.1 3917562 R 216594 CDS YP_001851495.1 183983204 6227481 complement(3918774..3919829) 1 NC_010612.1 HMGR is a tightly regulated enzyme, which catalyzes the synthesis of coenzyme A and mevalonate in isoprenoid synthesis. in mammals, this is the rate limiting committed step in cholesterol biosynthesis. bacteria, such as pseudomonas mevalonii, which rely solely on mevalonate for their carbon source, catalyze the reverse reaction, using an NAD-dependent HMGR to deacetylate mevalonate into 3- hydroxy-3-methylglutaryl-CoA; hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase 3919829 6227481 MMAR_3214 Mycobacterium marinum M hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase YP_001851495.1 3918774 R 216594 CDS YP_001851496.1 183983205 6227482 complement(3919853..3920965) 1 NC_010612.1 part of the mevalonate pathway for isoprenoid synthesis. possible regulatory role in mevalonate metabolism. converts (R)-5-phosphomevalonate to (R)-5- diphosphomevalonate; phosphomevalonate kinase 3920965 6227482 MMAR_3215 Mycobacterium marinum M phosphomevalonate kinase YP_001851496.1 3919853 R 216594 CDS YP_001851497.1 183983206 6227483 complement(3920962..3921972) 1 NC_010612.1 key enzyme in isoprenoid synthesis. converts (R)-5- diphosphomevalonate to phosphate + isopentenyl diphosphate + CO(2); diphosphomevalonate decarboxylase 3921972 6227483 MMAR_3216 Mycobacterium marinum M diphosphomevalonate decarboxylase YP_001851497.1 3920962 R 216594 CDS YP_001851498.1 183983207 6227484 complement(3921969..3922967) 1 NC_010612.1 converts (R)-mevalonate to (R)-5-phosphomevalonate (ATP dependant); mevalonate kinase, Erg12 3922967 erg12 6227484 erg12 Mycobacterium marinum M mevalonate kinase, Erg12 YP_001851498.1 3921969 R 216594 CDS YP_001851499.1 183983208 6227485 complement(3922982..3923506) 1 NC_010612.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3923506 idi 6227485 idi Mycobacterium marinum M isopentenyl-diphosphate delta-isomerase YP_001851499.1 3922982 R 216594 CDS YP_001851500.1 183983209 6227486 complement(3923702..3924739) 1 NC_010612.1 involved in biosynthesis of membrane ether-linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. catalyzes the consecutive condensation of homoallylic diphosphate of isopentenyl diphosphates (IPP, C5) with allylic diphosphates to synthesize prenyl diphosphates of various chain lengths; polyprenyl synthetase IdsB 3924739 idsB_1 6227486 idsB_1 Mycobacterium marinum M polyprenyl synthetase IdsB YP_001851500.1 3923702 R 216594 CDS YP_001851501.1 183983210 6227487 3925352..3926368 1 NC_010612.1 function unknown but possibly involved in catalysis of cyclisation cascades involving polyisoprene substrates; terpene cyclase 3926368 6227487 MMAR_3220 Mycobacterium marinum M terpene cyclase YP_001851501.1 3925352 D 216594 CDS YP_001851502.1 183983211 6227488 3926695..3927738 1 NC_010612.1 involved in fatty acid biosynthesis. catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl- acp. kas III catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. possesses both acetoacetyl-acp synthase and acetyl transacylase activities [catalytic activity: acyl- [acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]]; 3-oxoacyl-ACP synthase 3927738 fabH_1 6227488 fabH_1 Mycobacterium marinum M 3-oxoacyl-ACP synthase YP_001851502.1 3926695 D 216594 CDS YP_001851503.1 183983212 6227489 complement(3927931..3929319) 1 NC_010612.1 involved in chorismate biosynthesis; 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase 3929319 aroG 6227489 aroG Mycobacterium marinum M 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase YP_001851503.1 3927931 R 216594 CDS YP_001851504.1 183983213 6227490 complement(3929368..3929847) 1 NC_010612.1 hypothetical protein 3929847 6227490 MMAR_3223 Mycobacterium marinum M hypothetical protein YP_001851504.1 3929368 R 216594 CDS YP_001851505.1 183983214 6227491 complement(3929857..3930723) 1 NC_010612.1 hypothetical protein 3930723 6227491 MMAR_3224 Mycobacterium marinum M hypothetical protein YP_001851505.1 3929857 R 216594 CDS YP_001851506.1 183983215 6227492 3930815..3932098 1 NC_010612.1 hypothetical protein 3932098 6227492 MMAR_3225 Mycobacterium marinum M hypothetical protein YP_001851506.1 3930815 D 216594 CDS YP_001851507.1 183983216 6227493 complement(3932099..3932830) 1 NC_010612.1 transfer of fatty acyl groups; 1-acylglycerol-3-phosphate O-acyltransferase 3932830 6227493 MMAR_3226 Mycobacterium marinum M 1-acylglycerol-3-phosphate O-acyltransferase YP_001851507.1 3932099 R 216594 CDS YP_001851508.1 183983217 6227494 complement(3932918..3933307) 1 NC_010612.1 hypothetical protein 3933307 6227494 MMAR_3227 Mycobacterium marinum M hypothetical protein YP_001851508.1 3932918 R 216594 CDS YP_001851509.1 183983218 6227495 complement(3933304..3934503) 1 NC_010612.1 function unknown but domain identity suggests it is an anion-transporting ATPase; hypothetical protein 3934503 6227495 MMAR_3228 Mycobacterium marinum M hypothetical protein YP_001851509.1 3933304 R 216594 CDS YP_001851510.1 183983219 6227496 complement(3934575..3935009) 1 NC_010612.1 hypothetical protein 3935009 6227496 MMAR_3229 Mycobacterium marinum M hypothetical protein YP_001851510.1 3934575 R 216594 CDS YP_001851511.1 183983220 6227497 complement(3935106..3935495) 1 NC_010612.1 hypothetical protein 3935495 6227497 MMAR_3230 Mycobacterium marinum M hypothetical protein YP_001851511.1 3935106 R 216594 CDS YP_001851512.1 183983221 6227498 3935705..3937507 1 NC_010612.1 function unknown, but involved in lipid metabolism; long-chain-fatty-acid-CoA ligase FadD15 3937507 fadD15 6227498 fadD15 Mycobacterium marinum M long-chain-fatty-acid-CoA ligase FadD15 YP_001851512.1 3935705 D 216594 CDS YP_001851513.1 183983222 6227499 complement(3937803..3938960) 1 NC_010612.1 glycosyltransferase 3938960 6227499 MMAR_3232 Mycobacterium marinum M glycosyltransferase YP_001851513.1 3937803 R 216594 CDS YP_001851514.1 183983223 6227500 complement(3939032..3939889) 1 NC_010612.1 hypothetical protein 3939889 6227500 MMAR_3233 Mycobacterium marinum M hypothetical protein YP_001851514.1 3939032 R 216594 CDS YP_001851515.1 183983224 6227501 complement(3939903..3941063) 1 NC_010612.1 hypothetical protein 3941063 6227501 MMAR_3234 Mycobacterium marinum M hypothetical protein YP_001851515.1 3939903 R 216594 CDS YP_001851516.1 183983225 6227502 complement(3941238..3941492) 1 NC_010612.1 hypothetical protein 3941492 6227502 MMAR_5560 Mycobacterium marinum M hypothetical protein YP_001851516.1 3941238 R 216594 CDS YP_001851517.1 183983226 6227503 3941645..3943669 1 NC_010612.1 contains 3'-5'exonuclease domain; hypothetical protein 3943669 6227503 MMAR_3235 Mycobacterium marinum M hypothetical protein YP_001851517.1 3941645 D 216594 CDS YP_001851518.1 183983227 6227504 complement(3943544..3944647) 1 NC_010612.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 3944647 trpD 6227504 trpD Mycobacterium marinum M anthranilate phosphoribosyltransferase YP_001851518.1 3943544 R 216594 CDS YP_001851519.1 183983228 6227505 3944798..3945409 1 NC_010612.1 thought to be involved in aerobic respiration; cytochrome C oxidase (subunit III) CtaE 3945409 ctaE 6227505 ctaE Mycobacterium marinum M cytochrome C oxidase (subunit III) CtaE YP_001851519.1 3944798 D 216594 CDS YP_001851520.1 183983229 6227506 3945462..3946367 1 NC_010612.1 plays a role in aerobic respiration; ubiquinol-cytochrome C reductase QcrC 3946367 qcrC 6227506 qcrC Mycobacterium marinum M ubiquinol-cytochrome C reductase QcrC YP_001851520.1 3945462 D 216594 CDS YP_001851521.1 183983230 6227507 3946364..3947548 1 NC_010612.1 role in respiration; Rieske iron-sulfur protein QcrA 3947548 qcrA 6227507 qcrA Mycobacterium marinum M Rieske iron-sulfur protein QcrA YP_001851521.1 3946364 D 216594 CDS YP_001851522.1 183983231 6227508 3947545..3949230 1 NC_010612.1 role in respiration; ubiquinol-cytochrome C reductase QcrB 3949230 qcrB 6227508 qcrB Mycobacterium marinum M ubiquinol-cytochrome C reductase QcrB YP_001851522.1 3947545 D 216594 CDS YP_001851523.1 183983232 6227509 complement(3949676..3950314) 1 NC_010612.1 transmembrane protein 3950314 6227509 MMAR_3241 Mycobacterium marinum M transmembrane protein YP_001851523.1 3949676 R 216594 CDS YP_001851524.1 183983233 6227510 complement(3950314..3951261) 1 NC_010612.1 membrane protein MmpS3 3951261 mmpS3 6227510 mmpS3 Mycobacterium marinum M membrane protein MmpS3 YP_001851524.1 3950314 R 216594 CDS YP_001851525.1 183983234 6227511 complement(3951444..3951863) 1 NC_010612.1 integral membrane protein 3951863 6227511 MMAR_3243 Mycobacterium marinum M integral membrane protein YP_001851525.1 3951444 R 216594 CDS YP_001851526.1 183983235 6227512 complement(3951872..3952975) 1 NC_010612.1 involved in aerobic respiration. subunit I and II form the functional core of the enzyme complex. electrons originating in cytochrome C are transferred via HemE a and cu(a) to the binuclear center formed by HemE A3 and cu(B) (by similarity); transmembrane cytochrome C oxidase (subunit II) CtaC 3952975 ctaC 6227512 ctaC Mycobacterium marinum M transmembrane cytochrome C oxidase (subunit II) CtaC YP_001851526.1 3951872 R 216594 CDS YP_001851527.1 183983236 6227513 3953372..3955366 1 NC_010612.1 asparagine biosynthesis; asparagine synthetase AsnB 3955366 asnB 6227513 asnB Mycobacterium marinum M asparagine synthetase AsnB YP_001851527.1 3953372 D 216594 CDS YP_001851528.1 183983237 6227514 complement(3955379..3956353) 1 NC_010612.1 phosphorylation of carbohydrates; carbohydrate kinase CbhK 3956353 cbhK 6227514 cbhK Mycobacterium marinum M carbohydrate kinase CbhK YP_001851528.1 3955379 R 216594 CDS YP_001851529.1 183983238 6227515 3956545..3957234 1 NC_010612.1 hypothetical protein 3957234 6227515 MMAR_3247 Mycobacterium marinum M hypothetical protein YP_001851529.1 3956545 D 216594 CDS YP_001851530.1 183983239 6227516 complement(3957275..3957631) 1 NC_010612.1 function unknown but domain identity shows similarity to the HesB gene (function unknown) but which is expressed only under nitrogen fixation conditions; hypothetical protein 3957631 6227516 MMAR_3248 Mycobacterium marinum M hypothetical protein YP_001851530.1 3957275 R 216594 CDS YP_001851531.1 183983240 6227517 complement(3957717..3958862) 1 NC_010612.1 function unknown role in carbohydrate transport and metabolism; glycerate kinase 3958862 6227517 MMAR_3249 Mycobacterium marinum M glycerate kinase YP_001851531.1 3957717 R 216594 CDS YP_001851532.1 183983241 6227518 3958955..3959659 1 NC_010612.1 transmembrane protein 3959659 6227518 MMAR_3250 Mycobacterium marinum M transmembrane protein YP_001851532.1 3958955 D 216594 CDS YP_001851533.1 183983242 6227519 3959688..3960248 1 NC_010612.1 involved in cobalamin biosynthesis; bifunctional cobalamin biosynthesis protein CobU 3960248 cobU 6227519 cobU Mycobacterium marinum M bifunctional cobalamin biosynthesis protein CobU YP_001851533.1 3959688 D 216594 CDS YP_001851534.1 183983243 6227520 3960245..3961321 1 NC_010612.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 3961321 cobT 6227520 cobT Mycobacterium marinum M nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_001851534.1 3960245 D 216594 CDS YP_001851535.1 183983244 6227521 3961318..3962076 1 NC_010612.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 3962076 cobS 6227521 cobS Mycobacterium marinum M cobalamin synthase YP_001851535.1 3961318 D 216594 CDS YP_001851536.1 183983245 6227522 3962266..3963762 1 NC_010612.1 function unknown but domain identity with chloride channel superfamily; hypothetical protein 3963762 6227522 MMAR_3254 Mycobacterium marinum M hypothetical protein YP_001851536.1 3962266 D 216594 CDS YP_001851537.1 183983246 6227523 complement(3963754..3964860) 1 NC_010612.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 3964860 ilvE 6227523 ilvE Mycobacterium marinum M branched-chain amino acid aminotransferase YP_001851537.1 3963754 R 216594 CDS YP_001851538.1 183983247 6227524 complement(3964915..3966018) 1 NC_010612.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 3966018 gcvT 6227524 gcvT Mycobacterium marinum M glycine cleavage system aminomethyltransferase T YP_001851538.1 3964915 R 216594 CDS YP_001851539.1 183983248 6227525 3966063..3967208 1 NC_010612.1 adenylate cyclase 3967208 6227525 MMAR_3257 Mycobacterium marinum M adenylate cyclase YP_001851539.1 3966063 D 216594 CDS YP_001851540.1 183983249 6227526 3967220..3968779 1 NC_010612.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 3968779 pepB 6227526 pepB Mycobacterium marinum M leucyl aminopeptidase YP_001851540.1 3967220 D 216594 CDS YP_001851541.1 183983250 6227527 complement(3969244..3971028) 1 NC_010612.1 thought to be involved in detoxification reactions following oxidative damage to lipids; short chain dehydrogenase 3971028 ephD 6227527 ephD Mycobacterium marinum M short chain dehydrogenase YP_001851541.1 3969244 R 216594 CDS YP_001851542.1 183983251 6227528 3971257..3973023 1 NC_010612.1 involved in tricarboxylic acid cycle; converts 2- oxoglutarate to succinyl-CoA and CO2; dihydrolipoamide acetyltransferase 3973023 sucB 6227528 sucB Mycobacterium marinum M dihydrolipoamide acetyltransferase YP_001851542.1 3971257 D 216594 CDS YP_001851543.1 183983252 6227529 3973028..3973939 1 NC_010612.1 function unknown but domain identity with NAD dependent sugar epimerases; hypothetical protein 3973939 6227529 MMAR_3261 Mycobacterium marinum M hypothetical protein YP_001851543.1 3973028 D 216594 CDS YP_001851544.1 183983253 6227530 complement(3974086..3974850) 1 NC_010612.1 function unknown role in substrate movement; integral membrane protein ABC transporter 3974850 6227530 MMAR_3262 Mycobacterium marinum M integral membrane protein ABC transporter YP_001851544.1 3974086 R 216594 CDS YP_001851545.1 183983254 6227531 complement(3974940..3975905) 1 NC_010612.1 probably involved in active transport of substrate across the membrane (export). responsible for energy coupling to the transport system; ABC transporter ATP-binding protein 3975905 6227531 MMAR_3263 Mycobacterium marinum M ABC transporter ATP-binding protein YP_001851545.1 3974940 R 216594 CDS YP_001851546.1 183983255 6227532 complement(3976045..3978954) 1 NC_010612.1 thought to be involved in fatty acid transport; MmpL family transport protein 3978954 6227532 MMAR_3264 Mycobacterium marinum M MmpL family transport protein YP_001851546.1 3976045 R 216594 CDS YP_001851547.1 183983256 6227533 complement(3979389..3979619) 1 NC_010612.1 MbtH-like protein 3979619 6227533 MMAR_3265 Mycobacterium marinum M MbtH-like protein YP_001851547.1 3979389 R 216594 CDS YP_001851548.1 183983257 6227534 complement(3979902..3982811) 1 NC_010612.1 thought to be involved in fatty acid transport; MmpL family transport protein 3982811 6227534 MMAR_3266 Mycobacterium marinum M MmpL family transport protein YP_001851548.1 3979902 R 216594 CDS YP_001851549.1 183983258 6227535 complement(3982808..3983197) 1 NC_010612.1 transmembrane protein 3983197 6227535 MMAR_3267 Mycobacterium marinum M transmembrane protein YP_001851549.1 3982808 R 216594 CDS YP_001851550.1 183983259 6227536 3984467..4014043 1 NC_010612.1 involved in lipid metabolism. nine ext. modules, each module with predicted domain structure of C,a,T, domains ending in an integral te domain; non-ribosomal peptide synthetase 4014043 6227536 MMAR_3268 Mycobacterium marinum M non-ribosomal peptide synthetase YP_001851550.1 3984467 D 216594 CDS YP_001851551.1 183983260 6227538 4017092..4023604 1 NC_010612.1 synthesis of unknown metabolite. predicted structure: two extension modules, each with C, a & T domains. possible Thr & arg substrate; non-ribosomal peptide synthetase 4023604 6227538 MMAR_3270 Mycobacterium marinum M non-ribosomal peptide synthetase YP_001851551.1 4017092 D 216594 CDS YP_001851552.1 183983261 6227539 4023706..4037001 1 NC_010612.1 synthesis of unknown peptide - four predicted extension modules, each with domain structure C, a & T. final extension module End with an integral te domain. predicted, respective substrate specificity for each module: ThrE, Orn-D, arg, ThrE; non-ribosomal peptide synthetase 4037001 6227539 MMAR_3271 Mycobacterium marinum M non-ribosomal peptide synthetase YP_001851552.1 4023706 D 216594 CDS YP_001851553.1 183983262 6227540 complement(4037157..4038782) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 4038782 6227540 MMAR_3272 Mycobacterium marinum M long-chain-fatty-acid--CoA ligase YP_001851553.1 4037157 R 216594 CDS YP_001851554.1 183983263 6227541 complement(4039155..4039451) 1 NC_010612.1 function unknown; contains a phosphopantetheine attachment site, thus probably plays a role in this Nrp operon, perhaps for synthesis of a NRP/PKS fusion; hypothetical protein 4039451 6227541 MMAR_3273 Mycobacterium marinum M hypothetical protein YP_001851554.1 4039155 R 216594 CDS YP_001851555.1 183983264 6227542 4040050..4040277 1 NC_010612.1 hypothetical protein 4040277 6227542 MMAR_3274 Mycobacterium marinum M hypothetical protein YP_001851555.1 4040050 D 216594 CDS YP_001851556.1 183983265 6227543 complement(4040385..4040921) 1 NC_010612.1 hypothetical protein 4040921 6227543 MMAR_3275 Mycobacterium marinum M hypothetical protein YP_001851556.1 4040385 R 216594 CDS YP_001851557.1 183983266 6227544 4041056..4041709 1 NC_010612.1 the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released; alternative RNA polymerase sigma factor 4041709 6227544 MMAR_3276 Mycobacterium marinum M alternative RNA polymerase sigma factor YP_001851557.1 4041056 D 216594 CDS YP_001851558.1 183983267 6227545 4041699..4041983 1 NC_010612.1 hypothetical protein 4041983 6227545 MMAR_3277 Mycobacterium marinum M hypothetical protein YP_001851558.1 4041699 D 216594 CDS YP_001851559.1 183983268 6227546 4042510..4043262 1 NC_010612.1 multimeric flavodoxin WrbA 4043262 wrbA 6227546 wrbA Mycobacterium marinum M multimeric flavodoxin WrbA YP_001851559.1 4042510 D 216594 CDS YP_001851560.1 183983269 6227547 4043295..4044134 1 NC_010612.1 hypothetical protein 4044134 6227547 MMAR_3279 Mycobacterium marinum M hypothetical protein YP_001851560.1 4043295 D 216594 CDS YP_001851561.1 183983270 6227548 4044166..4044825 1 NC_010612.1 function unknown, may have methyltransferase activity; hypothetical protein 4044825 6227548 MMAR_3280 Mycobacterium marinum M hypothetical protein YP_001851561.1 4044166 D 216594 CDS YP_001851562.1 183983271 6227549 4044825..4046501 1 NC_010612.1 involved in valine and isoleucine biosynthesis (at the first step) [catalytic activity: 2-acetolactate + CO(2) = 2 pyruvate]; acetolactate synthase large subunit IlvB 4046501 ilvB1_2 6227549 ilvB1_2 Mycobacterium marinum M acetolactate synthase large subunit IlvB YP_001851562.1 4044825 D 216594 CDS YP_001851563.1 183983272 6227550 complement(4046526..4046918) 1 NC_010612.1 hypothetical protein 4046918 6227550 MMAR_3282 Mycobacterium marinum M hypothetical protein YP_001851563.1 4046526 R 216594 CDS YP_001851564.1 183983273 6227551 complement(4047002..4049158) 1 NC_010612.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; drug-transport transmembrane ABC transporter ATP-binding protein 4049158 6227551 MMAR_3283 Mycobacterium marinum M drug-transport transmembrane ABC transporter ATP-binding protein YP_001851564.1 4047002 R 216594 CDS YP_001851565.1 183983274 6227552 complement(4049331..4051172) 1 NC_010612.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; drug-transport transmembrane ABC transporter ATP-binding protein 4051172 6227552 MMAR_3284 Mycobacterium marinum M drug-transport transmembrane ABC transporter ATP-binding protein YP_001851565.1 4049331 R 216594 CDS YP_001851566.1 183983275 6227553 4051333..4052058 1 NC_010612.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 4052058 lipB 6227553 lipB Mycobacterium marinum M lipoate-protein ligase B YP_001851566.1 4051333 D 216594 CDS YP_001851567.1 183983276 6227554 4052055..4053029 1 NC_010612.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 4053029 lipA 6227554 lipA Mycobacterium marinum M lipoyl synthase YP_001851567.1 4052055 D 216594 CDS YP_001851568.1 183983277 6227555 4053056..4053808 1 NC_010612.1 transmembrane protein 4053808 6227555 MMAR_3287 Mycobacterium marinum M transmembrane protein YP_001851568.1 4053056 D 216594 CDS YP_001851569.1 183983278 6227556 complement(4053858..4054280) 1 NC_010612.1 hypothetical protein 4054280 6227556 MMAR_3288 Mycobacterium marinum M hypothetical protein YP_001851569.1 4053858 R 216594 CDS YP_001851570.1 183983279 6227557 4054523..4055959 1 NC_010612.1 involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate]; glutamine synthetase GlnA1 4055959 glnA1 6227557 glnA1 Mycobacterium marinum M glutamine synthetase GlnA1 YP_001851570.1 4054523 D 216594 CDS YP_001851571.1 183983280 6227558 4056223..4058403 1 NC_010612.1 function unknown. has fibronectin-binding activity (could thus mediate bacterial attachment to host cells). thought to be expressed during infection; PE-PGRS family protein 4058403 6227558 MMAR_3290 Mycobacterium marinum M PE-PGRS family protein YP_001851571.1 4056223 D 216594 CDS YP_001851572.1 183983281 6227559 complement(4058448..4059308) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hypothetical protein 4059308 6227559 MMAR_3291 Mycobacterium marinum M hypothetical protein YP_001851572.1 4058448 R 216594 CDS YP_001851573.1 183983282 6227560 complement(4059305..4059943) 1 NC_010612.1 hypothetical protein 4059943 6227560 MMAR_3292 Mycobacterium marinum M hypothetical protein YP_001851573.1 4059305 R 216594 CDS YP_001851574.1 183983283 6227561 complement(4059957..4062944) 1 NC_010612.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 4062944 glnE 6227561 glnE Mycobacterium marinum M bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_001851574.1 4059957 R 216594 CDS YP_001851575.1 183983284 6227562 complement(4063015..4064355) 1 NC_010612.1 involved in glutamine biosynthesis [catalytic activity: ATP + L-glutamate + NH(3) = ADP + glutamine + orthophosphate]; glutamine synthetase 4064355 glnA2 6227562 glnA2 Mycobacterium marinum M glutamine synthetase YP_001851575.1 4063015 R 216594 CDS YP_001851576.1 183983285 6227563 complement(4064445..4066025) 1 NC_010612.1 function unknown; thought to hydrolyze peptides and/or proteins; exported protease 4066025 6227563 MMAR_3295 Mycobacterium marinum M exported protease YP_001851576.1 4064445 R 216594 CDS YP_001851577.1 183983286 6227564 complement(4066074..4067807) 1 NC_010612.1 cytochrome C oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. electrons originating in cytochrome C are transferred via the copper a center of subunit 2 and HemE a of subunit 1 to the bimetallic center formed by HemE A3 and copper B [catalytic activity: 4 ferrocytochrome C + O(2) = 2 H(2)O + 4 ferricytochrome C]; cytochrome C oxidase polypeptide I CtaD 4067807 ctaD_1 6227564 ctaD_1 Mycobacterium marinum M cytochrome C oxidase polypeptide I CtaD YP_001851577.1 4066074 R 216594 CDS YP_001851578.1 183983287 6227565 complement(4067951..4069507) 1 NC_010612.1 function unknown; thought to hydrolyze peptides and/or proteins; exported protease 4069507 6227565 MMAR_3297 Mycobacterium marinum M exported protease YP_001851578.1 4067951 R 216594 CDS YP_001851579.1 183983288 6227566 complement(4069567..4070958) 1 NC_010612.1 hypothetical protein 4070958 6227566 MMAR_3298 Mycobacterium marinum M hypothetical protein YP_001851579.1 4069567 R 216594 CDS YP_001851580.1 183983289 6227567 4071106..4071999 1 NC_010612.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 4071999 panB 6227567 panB Mycobacterium marinum M 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_001851580.1 4071106 D 216594 CDS YP_001851581.1 183983290 6227568 complement(4072007..4072519) 1 NC_010612.1 hypothetical protein 4072519 6227568 MMAR_3300 Mycobacterium marinum M hypothetical protein YP_001851581.1 4072007 R 216594 CDS YP_001851582.1 183983291 6227569 4072592..4074184 1 NC_010612.1 hypothetical protein 4074184 6227569 MMAR_3301 Mycobacterium marinum M hypothetical protein YP_001851582.1 4072592 D 216594 CDS YP_001851583.1 183983292 6227570 4074778..4075587 1 NC_010612.1 hypothetical protein 4075587 6227570 MMAR_3302 Mycobacterium marinum M hypothetical protein YP_001851583.1 4074778 D 216594 CDS YP_001851584.1 183983293 6227571 complement(4075650..4078139) 1 NC_010612.1 function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages; PE-PGRS family protein 4078139 6227571 MMAR_3303 Mycobacterium marinum M PE-PGRS family protein YP_001851584.1 4075650 R 216594 CDS YP_001851585.1 183983294 6227573 complement(4079095..4080219) 1 NC_010612.1 bifunctional RNase H/acid phosphatase 4080219 6227573 MMAR_3304 Mycobacterium marinum M bifunctional RNase H/acid phosphatase YP_001851585.1 4079095 R 216594 CDS YP_001851586.1 183983295 6227574 complement(4080216..4080953) 1 NC_010612.1 hypothetical protein 4080953 6227574 MMAR_3305 Mycobacterium marinum M hypothetical protein YP_001851586.1 4080216 R 216594 CDS YP_001851587.1 183983296 6227575 complement(4080976..4082112) 1 NC_010612.1 hypothetical protein 4082112 6227575 MMAR_3306 Mycobacterium marinum M hypothetical protein YP_001851587.1 4080976 R 216594 CDS YP_001851588.1 183983297 6227576 complement(4082109..4083161) 1 NC_010612.1 involved in cobalamin biosynthesis; hypothetical protein 4083161 cobC 6227576 cobC Mycobacterium marinum M hypothetical protein YP_001851588.1 4082109 R 216594 CDS YP_001851589.1 183983298 6227577 4083439..4084071 1 NC_010612.1 hypothetical protein 4084071 6227577 MMAR_3308 Mycobacterium marinum M hypothetical protein YP_001851589.1 4083439 D 216594 CDS YP_001851590.1 183983299 6227578 4084064..4084558 1 NC_010612.1 involved in signal transduction (via dephosphorylation). can dephosphorylated in vitro the phosphotyrosine residue of myelin basic protein (MBP) at ph 7.0 [catalytic activity: protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate; phosphotyrosine protein phosphatase PtpA 4084558 ptpA 6227578 ptpA Mycobacterium marinum M phosphotyrosine protein phosphatase PtpA YP_001851590.1 4084064 D 216594 CDS YP_001851591.1 183983300 6227579 4084558..4085382 1 NC_010612.1 function unknown: may be involved in the ability to survive in macrophages; transmembrane protein 4085382 6227579 MMAR_3310 Mycobacterium marinum M transmembrane protein YP_001851591.1 4084558 D 216594 CDS YP_001851592.1 183983301 6227580 complement(4085364..4086305) 1 NC_010612.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group; cobalamin biosynthesis protein 4086305 cobD 6227580 cobD Mycobacterium marinum M cobalamin biosynthesis protein YP_001851592.1 4085364 R 216594 CDS YP_001851593.1 183983302 6227581 4086419..4087234 1 NC_010612.1 hypothetical protein 4087234 6227581 MMAR_3312 Mycobacterium marinum M hypothetical protein YP_001851593.1 4086419 D 216594 CDS YP_001851594.1 183983303 6227582 complement(4087255..4088184) 1 NC_010612.1 function unknown; possibly involved in transport of metal ions across the membrane; hypothetical protein 4088184 6227582 MMAR_3313 Mycobacterium marinum M hypothetical protein YP_001851594.1 4087255 R 216594 CDS YP_001851595.1 183983304 6227583 complement(4088273..4089397) 1 NC_010612.1 function unknown; contains high domain identity with epoxide hydrolases. they comprise a group of functionally related enzymes that catalyse the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. in animals, the major interest in eh is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three- membered ring system and the strong polarisation of the C-- O bonds. this is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. this family is often found in conjunction with pfam00561; hydrolase 4089397 6227583 MMAR_3314 Mycobacterium marinum M hydrolase YP_001851595.1 4088273 R 216594 CDS YP_001851596.1 183983305 6227584 4089537..4090943 1 NC_010612.1 transposition of ISMyma07; transposase for ISMyma07 4090943 6227584 MMAR_3315 Mycobacterium marinum M transposase for ISMyma07 YP_001851596.1 4089537 D 216594 CDS YP_001851597.1 183983306 6227585 4091225..4094122 1 NC_010612.1 PE-PGRS family protein 4094122 6227585 MMAR_3316 Mycobacterium marinum M PE-PGRS family protein YP_001851597.1 4091225 D 216594 CDS YP_001851598.1 183983307 6227586 4094242..4095648 1 NC_010612.1 transposition of ISMyma07; transposase for ISMyma07 4095648 6227586 MMAR_3317 Mycobacterium marinum M transposase for ISMyma07 YP_001851598.1 4094242 D 216594 CDS YP_001851599.1 183983308 6227587 complement(4095830..4096024) 1 NC_010612.1 hypothetical protein 4096024 6227587 MMAR_3318 Mycobacterium marinum M hypothetical protein YP_001851599.1 4095830 R 216594 CDS YP_001851600.1 183983309 6227588 complement(4096159..4097169) 1 NC_010612.1 function unknown; probably involved in cellular metabolism; dehydrogenase 4097169 6227588 MMAR_3319 Mycobacterium marinum M dehydrogenase YP_001851600.1 4096159 R 216594 CDS YP_001851601.1 183983310 6227589 complement(4097273..4098307) 1 NC_010612.1 involved in transcriptional mechanism; AraC/XylS family transcriptional regulator 4098307 6227589 MMAR_3320 Mycobacterium marinum M AraC/XylS family transcriptional regulator YP_001851601.1 4097273 R 216594 CDS YP_001851602.1 183983311 6227590 complement(4098380..4099801) 1 NC_010612.1 function unknown; contains a putative glyoxylase domain; hypothetical protein 4099801 6227590 MMAR_3321 Mycobacterium marinum M hypothetical protein YP_001851602.1 4098380 R 216594 CDS YP_001851603.1 183983312 6227591 complement(4099812..4100825) 1 NC_010612.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component (beta subunit) 4100825 6227591 MMAR_3322 Mycobacterium marinum M pyruvate dehydrogenase E1 component (beta subunit) YP_001851603.1 4099812 R 216594 CDS YP_001851604.1 183983313 6227592 complement(4100822..4101883) 1 NC_010612.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component (alpha subunit) 4101883 6227592 MMAR_3323 Mycobacterium marinum M pyruvate dehydrogenase E1 component (alpha subunit) YP_001851604.1 4100822 R 216594 CDS YP_001851605.1 183983314 6227593 complement(4101943..4102944) 1 NC_010612.1 function unknown; nucleoside-diphosphate-sugar epimerase 4102944 6227593 MMAR_3324 Mycobacterium marinum M nucleoside-diphosphate-sugar epimerase YP_001851605.1 4101943 R 216594 CDS YP_001851606.1 183983315 6227594 4103313..4103873 1 NC_010612.1 hypothetical protein 4103873 6227594 MMAR_3325 Mycobacterium marinum M hypothetical protein YP_001851606.1 4103313 D 216594 CDS YP_001851607.1 183983316 6227595 4104294..4106909 1 NC_010612.1 PE-PGRS family protein 4106909 6227595 MMAR_3326 Mycobacterium marinum M PE-PGRS family protein YP_001851607.1 4104294 D 216594 CDS YP_001851608.1 183983317 6227596 4107086..4107646 1 NC_010612.1 hypothetical protein 4107646 6227596 MMAR_3327 Mycobacterium marinum M hypothetical protein YP_001851608.1 4107086 D 216594 CDS YP_001851609.1 183983318 6227597 4107646..4108728 1 NC_010612.1 oxido-reduction; zinc-dependent alcohol dehydrogenase AdhE2 4108728 adhE2_1 6227597 adhE2_1 Mycobacterium marinum M zinc-dependent alcohol dehydrogenase AdhE2 YP_001851609.1 4107646 D 216594 CDS YP_001851610.1 183983319 6227598 4108765..4110237 1 NC_010612.1 hypothetical protein 4110237 6227598 MMAR_3329 Mycobacterium marinum M hypothetical protein YP_001851610.1 4108765 D 216594 CDS YP_001851611.1 183983320 6227599 4110234..4111784 1 NC_010612.1 hypothetical protein 4111784 6227599 MMAR_3330 Mycobacterium marinum M hypothetical protein YP_001851611.1 4110234 D 216594 CDS YP_001851612.1 183983321 6227601 complement(4111923..4112384) 1 NC_010612.1 detoxification of organic peroxides; peroxiredoxin AhpE 4112384 ahpE 6227601 ahpE Mycobacterium marinum M peroxiredoxin AhpE YP_001851612.1 4111923 R 216594 CDS YP_001851613.1 183983322 6227602 complement(4112384..4112830) 1 NC_010612.1 hypothetical protein 4112830 6227602 MMAR_3332 Mycobacterium marinum M hypothetical protein YP_001851613.1 4112384 R 216594 CDS YP_001851614.1 183983323 6227603 complement(4112887..4113489) 1 NC_010612.1 N-term truncated (missing first 69aa) compared to M. tuberculosis; hypothetical protein 4113489 6227603 MMAR_3333 Mycobacterium marinum M hypothetical protein YP_001851614.1 4112887 R 216594 CDS YP_001851615.1 183983324 6227604 4113674..4116463 1 NC_010612.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 4116463 aceE 6227604 aceE Mycobacterium marinum M pyruvate dehydrogenase subunit E1 YP_001851615.1 4113674 D 216594 CDS YP_001851616.1 183983325 6227605 4116597..4117907 1 NC_010612.1 hypothetical protein 4117907 6227605 MMAR_3335 Mycobacterium marinum M hypothetical protein YP_001851616.1 4116597 D 216594 CDS YP_001851617.1 183983326 6227606 4118069..4118977 1 NC_010612.1 catalyzes malonyl-CoA-acp transacylase (McaT) activity using holo-AcpM as substrate for transacylation [catalytic activity: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]; malonyl CoA-acyl carrier protein transacylase FabD 4118977 fabD 6227606 fabD Mycobacterium marinum M malonyl CoA-acyl carrier protein transacylase FabD YP_001851617.1 4118069 D 216594 CDS YP_001851618.1 183983327 6227607 4119050..4119397 1 NC_010612.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 4119397 acpP 6227607 acpP Mycobacterium marinum M acyl carrier protein YP_001851618.1 4119050 D 216594 CDS YP_001851619.1 183983328 6227608 4119394..4120644 1 NC_010612.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 4120644 kasA 6227608 kasA Mycobacterium marinum M 3-oxoacyl-(acyl carrier protein) synthase II YP_001851619.1 4119394 D 216594 CDS YP_001851620.1 183983329 6227609 4120726..4121979 1 NC_010612.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 4121979 kasB 6227609 kasB Mycobacterium marinum M 3-oxoacyl-(acyl carrier protein) synthase II YP_001851620.1 4120726 D 216594 CDS YP_001851621.1 183983330 6227610 4122017..4123438 1 NC_010612.1 involved in fatty acid biosynthesis (mycolic acids synthesis) [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl- CoA]; acetyl/propionyl CoA carboxylase subunit beta 4123438 accD6 6227610 accD6 Mycobacterium marinum M acetyl/propionyl CoA carboxylase subunit beta YP_001851621.1 4122017 D 216594 CDS YP_001851622.1 183983331 6227611 4123564..4124451 1 NC_010612.1 hypothetical protein 4124451 6227611 MMAR_3341 Mycobacterium marinum M hypothetical protein YP_001851622.1 4123564 D 216594 CDS YP_001851623.1 183983332 6227612 complement(4124532..4126067) 1 NC_010612.1 involved in aerobic respiration and oxydation of glycerol. reduces an acceptor and generates glycerone phosphate from SN-glycerol 3-phosphate. possibly play a role in metabolism of riboflavin, fad,FMN [catalytic activity: SN-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor]; glycerol-3-phosphate dehydrogenase 4126067 glpD1 6227612 glpD1 Mycobacterium marinum M glycerol-3-phosphate dehydrogenase YP_001851623.1 4124532 R 216594 CDS YP_001851624.1 183983333 6227613 complement(4126067..4126636) 1 NC_010612.1 possibly involved in transcriptional regulation; transcriptional regulatory protein 4126636 6227613 MMAR_3343 Mycobacterium marinum M transcriptional regulatory protein YP_001851624.1 4126067 R 216594 CDS YP_001851625.1 183983334 6227614 4126684..4128264 1 NC_010612.1 electron acceptor; flavoprotein 4128264 6227614 MMAR_3344 Mycobacterium marinum M flavoprotein YP_001851625.1 4126684 D 216594 CDS YP_001851626.1 183983335 6227615 4128261..4129223 1 NC_010612.1 involved in the biosynthesis of phosphatidylinositol mannosides (PIMs); the enzyme from Mycobacterium tuberculosis can phosphorylate a variety of amphipathic lipids; diacylglycerol kinase 4129223 6227615 MMAR_3345 Mycobacterium marinum M diacylglycerol kinase YP_001851626.1 4128261 D 216594 CDS YP_001851627.1 183983336 6227616 4129346..4129864 1 NC_010612.1 hypothetical protein 4129864 6227616 MMAR_3346 Mycobacterium marinum M hypothetical protein YP_001851627.1 4129346 D 216594 CDS YP_001851628.1 183983337 6227617 complement(4129870..4130382) 1 NC_010612.1 hypothetical protein 4130382 6227617 MMAR_3347 Mycobacterium marinum M hypothetical protein YP_001851628.1 4129870 R 216594 CDS YP_001851629.1 183983338 6227618 complement(4130536..4131354) 1 NC_010612.1 hypothetical protein 4131354 6227618 MMAR_3348 Mycobacterium marinum M hypothetical protein YP_001851629.1 4130536 R 216594 CDS YP_001851630.1 183983339 6227619 complement(4131367..4132437) 1 NC_010612.1 possibly involved in transcriptional regulation; transcriptional regulatory protein 4132437 6227619 MMAR_3349 Mycobacterium marinum M transcriptional regulatory protein YP_001851630.1 4131367 R 216594 CDS YP_001851631.1 183983340 6227620 4132568..4133653 1 NC_010612.1 oxido-reduction; zinc-dependent alcohol dehydrogenase AdhE2 4133653 adhE2 6227620 adhE2 Mycobacterium marinum M zinc-dependent alcohol dehydrogenase AdhE2 YP_001851631.1 4132568 D 216594 CDS YP_001851632.1 183983341 6227621 4133653..4134276 1 NC_010612.1 hypothetical protein 4134276 6227621 MMAR_3351 Mycobacterium marinum M hypothetical protein YP_001851632.1 4133653 D 216594 CDS YP_001851633.1 183983342 6227622 complement(4134439..4135836) 1 NC_010612.1 transposition of insertion sequence element ISMyma02; transposase for insertion sequence ISMyma02 4135836 6227622 MMAR_3352 Mycobacterium marinum M transposase for insertion sequence ISMyma02 YP_001851633.1 4134439 R 216594 CDS YP_001851634.1 183983343 6227623 complement(4136022..4136771) 1 NC_010612.1 function unknown; hypothetical protein 4136771 6227623 MMAR_3353 Mycobacterium marinum M hypothetical protein YP_001851634.1 4136022 R 216594 CDS YP_001851635.1 183983344 6227624 complement(4136768..4138216) 1 NC_010612.1 Predicted to be involved in lipoprotein acylation; apolipoprotein n-acyltransferase, Lnt 4138216 lnt 6227624 lnt Mycobacterium marinum M apolipoprotein n-acyltransferase, Lnt YP_001851635.1 4136768 R 216594 CDS YP_001851636.1 183983345 6227625 4138353..4139306 1 NC_010612.1 oxidoreduction; short chain dehydrogenase 4139306 6227625 MMAR_3355 Mycobacterium marinum M short chain dehydrogenase YP_001851636.1 4138353 D 216594 CDS YP_001851637.1 183983346 6227626 4139308..4140414 1 NC_010612.1 hypothetical protein 4140414 6227626 MMAR_3356 Mycobacterium marinum M hypothetical protein YP_001851637.1 4139308 D 216594 CDS YP_001851638.1 183983347 6227627 4140509..4140865 1 NC_010612.1 function unknown; hypothetical protein 4140865 6227627 MMAR_3357 Mycobacterium marinum M hypothetical protein YP_001851638.1 4140509 D 216594 CDS YP_001851639.1 183983348 6227628 complement(4140889..4142826) 1 NC_010612.1 hypothetical protein 4142826 6227628 MMAR_3358 Mycobacterium marinum M hypothetical protein YP_001851639.1 4140889 R 216594 CDS YP_001851640.1 183983349 6227629 complement(4142958..4144043) 1 NC_010612.1 hypothetical protein 4144043 6227629 MMAR_3359 Mycobacterium marinum M hypothetical protein YP_001851640.1 4142958 R 216594 CDS YP_001851641.1 183983350 6227630 4144258..4144596 1 NC_010612.1 transmembrane protein, MmpS5_2 4144596 mmpS5_2 6227630 mmpS5_2 Mycobacterium marinum M transmembrane protein, MmpS5_2 YP_001851641.1 4144258 D 216594 CDS YP_001851642.1 183983351 6227631 4144702..4146003 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 124A1, Cyp124A1 4146003 cyp124A1 6227631 cyp124A1 Mycobacterium marinum M cytochrome P450 124A1, Cyp124A1 YP_001851642.1 4144702 D 216594 CDS YP_001851643.1 183983352 6227632 4146037..4147410 1 NC_010612.1 possibly catalyzes the oxidative deamination: oxidize on primary amines, and perhaps on secondary and tertiary amines [catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RchO + NH(3) + H(2)O(2)]. must have important function in metabolism. supposed involved in stationary- phase survival; flavin-containing monoamine oxidase AofH 4147410 aofH_1 6227632 aofH_1 Mycobacterium marinum M flavin-containing monoamine oxidase AofH YP_001851643.1 4146037 D 216594 CDS YP_001851644.1 183983353 6227633 complement(4147419..4148045) 1 NC_010612.1 hypothetical protein 4148045 6227633 MMAR_3363 Mycobacterium marinum M hypothetical protein YP_001851644.1 4147419 R 216594 CDS YP_001851645.1 183983354 6227634 complement(4148139..4149326) 1 NC_010612.1 function unknown; hypothetical protein 4149326 6227634 MMAR_3364 Mycobacterium marinum M hypothetical protein YP_001851645.1 4148139 R 216594 CDS YP_001851646.1 183983355 6227635 4149514..4150071 1 NC_010612.1 hypothetical protein 4150071 6227635 MMAR_3365 Mycobacterium marinum M hypothetical protein YP_001851646.1 4149514 D 216594 CDS YP_001851647.1 183983356 6227636 4150140..4150673 1 NC_010612.1 lipoprotein LppN 4150673 lppN 6227636 lppN Mycobacterium marinum M lipoprotein LppN YP_001851647.1 4150140 D 216594 CDS YP_001851648.1 183983357 6227637 4150670..4151068 1 NC_010612.1 hypothetical protein 4151068 6227637 MMAR_3367 Mycobacterium marinum M hypothetical protein YP_001851648.1 4150670 D 216594 CDS YP_001851649.1 183983358 6227638 4151267..4151644 1 NC_010612.1 transmembrane protein 4151644 6227638 MMAR_3368 Mycobacterium marinum M transmembrane protein YP_001851649.1 4151267 D 216594 CDS YP_001851650.1 183983359 6227639 4151641..4151976 1 NC_010612.1 function unknown; transmembrane protein 4151976 6227639 MMAR_3369 Mycobacterium marinum M transmembrane protein YP_001851650.1 4151641 D 216594 CDS YP_001851651.1 183983360 6227640 complement(4152000..4152734) 1 NC_010612.1 function unknown, in general, cation channels are transport proteins responsible for the movement of cations through the membrane; ion transport protein 4152734 6227640 MMAR_3370 Mycobacterium marinum M ion transport protein YP_001851651.1 4152000 R 216594 CDS YP_001851652.1 183983361 6227641 complement(4152886..4153596) 1 NC_010612.1 function unknown; predicted hydrolase (had superfamily) domain; hypothetical protein 4153596 6227641 MMAR_3371 Mycobacterium marinum M hypothetical protein YP_001851652.1 4152886 R 216594 CDS YP_001851653.1 183983362 6227642 4153682..4153963 1 NC_010612.1 transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa1 4153963 6227642 MMAR_3372 Mycobacterium marinum M transposase, ISMyma01_aa1 YP_001851653.1 4153682 D 216594 CDS YP_001851654.1 183983363 6227643 4154005..4154799 1 NC_010612.1 transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa2 4154799 6227643 MMAR_3373 Mycobacterium marinum M transposase, ISMyma01_aa2 YP_001851654.1 4154005 D 216594 CDS YP_001851655.1 183983364 6227644 complement(4154960..4155430) 1 NC_010612.1 hypothetical protein 4155430 6227644 MMAR_3374 Mycobacterium marinum M hypothetical protein YP_001851655.1 4154960 R 216594 CDS YP_001851656.1 183983365 6227645 complement(4155454..4156461) 1 NC_010612.1 hypothetical protein 4156461 6227645 MMAR_3375 Mycobacterium marinum M hypothetical protein YP_001851656.1 4155454 R 216594 CDS YP_001851657.1 183983366 6227646 complement(4157159..4157638) 1 NC_010612.1 contains PTPS, 6-pyruvoyl tetrahydropterin synthase domain. 6-pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6- pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. the functional enzyme is a hexamer of identical subunits; 6-pyruvoyl tetrahydrobiopterin synthase 4157638 6227646 MMAR_3376 Mycobacterium marinum M 6-pyruvoyl tetrahydrobiopterin synthase YP_001851657.1 4157159 R 216594 CDS YP_001851658.1 183983367 6227647 complement(4158033..4158188) 1 NC_010612.1 hypothetical protein 4158188 6227647 MMAR_3377 Mycobacterium marinum M hypothetical protein YP_001851658.1 4158033 R 216594 CDS YP_001851659.1 183983368 6227648 complement(4158378..4159550) 1 NC_010612.1 PPE family protein 4159550 6227648 MMAR_3378 Mycobacterium marinum M PPE family protein YP_001851659.1 4158378 R 216594 CDS YP_001851660.1 183983369 6227649 complement(4159597..4160790) 1 NC_010612.1 PPE family protein 4160790 6227649 MMAR_3379 Mycobacterium marinum M PPE family protein YP_001851660.1 4159597 R 216594 CDS YP_001851661.1 183983370 6227651 complement(4161654..4161866) 1 NC_010612.1 transposition of an insertion sequence; transposase ISMyma01_aa1-like protein 4161866 6227651 MMAR_3380 Mycobacterium marinum M transposase ISMyma01_aa1-like protein YP_001851661.1 4161654 R 216594 CDS YP_001851662.1 183983371 6227652 complement(4162042..4163643) 1 NC_010612.1 hypothetical protein 4163643 6227652 MMAR_3381 Mycobacterium marinum M hypothetical protein YP_001851662.1 4162042 R 216594 CDS YP_001851663.1 183983372 6227653 complement(4163700..4164473) 1 NC_010612.1 hypothetical protein 4164473 6227653 MMAR_3382 Mycobacterium marinum M hypothetical protein YP_001851663.1 4163700 R 216594 CDS YP_001851664.1 183983373 6227654 4165091..4165882 1 NC_010612.1 FabG-like dehydrogenase 4165882 6227654 MMAR_3383 Mycobacterium marinum M FabG-like dehydrogenase YP_001851664.1 4165091 D 216594 CDS YP_001851665.1 183983374 6227655 4165983..4167638 1 NC_010612.1 function unknown but contains identity with hydroxylase domain; hydroxylase 4167638 6227655 MMAR_3384 Mycobacterium marinum M hydroxylase YP_001851665.1 4165983 D 216594 CDS YP_001851666.1 183983375 6227656 4167635..4168903 1 NC_010612.1 hypothetical protein 4168903 6227656 MMAR_3385 Mycobacterium marinum M hypothetical protein YP_001851666.1 4167635 D 216594 CDS YP_001851667.1 183983376 6227657 4169863..4170456 1 NC_010612.1 Involved in synthesis of cell wall components that are required to inhibit phagosome maturation; Phagosome maturation inhibitor, PmiA 4170456 pmiA 6227657 pmiA Mycobacterium marinum M Phagosome maturation inhibitor, PmiA YP_001851667.1 4169863 D 216594 CDS YP_001851668.1 183983377 6227658 complement(4170703..4171899) 1 NC_010612.1 domain identity with beta-lactamase class C and other penicillin binding proteins; hypothetical protein 4171899 6227658 MMAR_3387 Mycobacterium marinum M hypothetical protein YP_001851668.1 4170703 R 216594 CDS YP_001851669.1 183983378 6227659 complement(4171896..4173374) 1 NC_010612.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; biotin carboxylase-like protein 4173374 6227659 MMAR_3388 Mycobacterium marinum M biotin carboxylase-like protein YP_001851669.1 4171896 R 216594 CDS YP_001851670.1 183983379 6227660 4173681..4175528 1 NC_010612.1 function unknown role in lipid metabolism; fatty-acid-CoA ligase 4175528 6227660 MMAR_3389 Mycobacterium marinum M fatty-acid-CoA ligase YP_001851670.1 4173681 D 216594 CDS YP_001851671.1 183983380 6227661 4175571..4176503 1 NC_010612.1 hydrolase 4176503 6227661 MMAR_3390 Mycobacterium marinum M hydrolase YP_001851671.1 4175571 D 216594 CDS YP_001851672.1 183983381 6227662 4176762..4178063 1 NC_010612.1 hypothetical protein 4178063 6227662 MMAR_3391 Mycobacterium marinum M hypothetical protein YP_001851672.1 4176762 D 216594 CDS YP_001851673.1 183983382 6227663 4178221..4178733 1 NC_010612.1 hypothetical protein 4178733 6227663 MMAR_3392 Mycobacterium marinum M hypothetical protein YP_001851673.1 4178221 D 216594 CDS YP_001851674.1 183983383 6227664 4178898..4179551 1 NC_010612.1 methyltransferase 4179551 6227664 MMAR_3393 Mycobacterium marinum M methyltransferase YP_001851674.1 4178898 D 216594 CDS YP_001851675.1 183983384 6227665 4179781..4181016 1 NC_010612.1 function unknown; probably involved in cellular metabolism; hypothetical protein 4181016 6227665 MMAR_3394 Mycobacterium marinum M hypothetical protein YP_001851675.1 4179781 D 216594 CDS YP_001851676.1 183983385 6227666 4181044..4181703 1 NC_010612.1 methyltransferase (methylase) 4181703 6227666 MMAR_3395 Mycobacterium marinum M methyltransferase (methylase) YP_001851676.1 4181044 D 216594 CDS YP_001851677.1 183983386 6227667 complement(4181725..4182126) 1 NC_010612.1 hypothetical protein 4182126 6227667 MMAR_3396 Mycobacterium marinum M hypothetical protein YP_001851677.1 4181725 R 216594 CDS YP_001851678.1 183983387 6227668 4182222..4182818 1 NC_010612.1 putative regulatory protein 4182818 6227668 MMAR_3397 Mycobacterium marinum M putative regulatory protein YP_001851678.1 4182222 D 216594 CDS YP_001851679.1 183983388 6227669 4182921..4184789 1 NC_010612.1 involved in signal transduction (via phosphorylation). thought to regulate phosphate transport. can phosphorylate the peptide substrate myelin basic protein (MBP) at serine and threonine residues. can be autophosphorylated on threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 4184789 6227669 MMAR_3398 Mycobacterium marinum M Ser/Thr protein kinase YP_001851679.1 4182921 D 216594 CDS YP_001851680.1 183983389 6227670 complement(4184882..4186258) 1 NC_010612.1 function unknown, possibly involved in cell wall biosynthesis. contains a putative beta-lactamase domain; hypothetical protein 4186258 6227670 MMAR_3399 Mycobacterium marinum M hypothetical protein YP_001851680.1 4184882 R 216594 CDS YP_001851681.1 183983390 6227671 4187433..4189922 1 NC_010612.1 PE-PGRS family protein 4189922 6227671 MMAR_3400 Mycobacterium marinum M PE-PGRS family protein YP_001851681.1 4187433 D 216594 CDS YP_001851682.1 183983391 6227672 4190040..4190795 1 NC_010612.1 metabolism of malonate; maleate cis-trans isomerase 4190795 6227672 MMAR_3401 Mycobacterium marinum M maleate cis-trans isomerase YP_001851682.1 4190040 D 216594 CDS YP_001851683.1 183983392 6227673 complement(4190882..4192330) 1 NC_010612.1 function unknown; member of the mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins; PE-PGRS family protein 4192330 6227673 MMAR_3402 Mycobacterium marinum M PE-PGRS family protein YP_001851683.1 4190882 R 216594 CDS YP_001851684.1 183983393 6227674 4192705..4194105 1 NC_010612.1 hypothetical protein 4194105 6227674 MMAR_3403 Mycobacterium marinum M hypothetical protein YP_001851684.1 4192705 D 216594 CDS YP_001851685.1 183983394 6227675 4194345..4199147 1 NC_010612.1 function unknown; contains a N-term serine/threonine protein kinases, catalytic domain and two C-term WD40 domains. WD40 domains are found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the wd dipeptide at its c-terminus and is 40 residues long, hence the name WD40; putative regulatory protein 4199147 6227675 MMAR_3405 Mycobacterium marinum M putative regulatory protein YP_001851685.1 4194345 D 216594 CDS YP_001851686.1 183983395 6227676 complement(4199425..4200816) 1 NC_010612.1 hypothetical protein 4200816 6227676 MMAR_3406 Mycobacterium marinum M hypothetical protein YP_001851686.1 4199425 R 216594 CDS YP_001851687.1 183983396 6227677 4200926..4202611 1 NC_010612.1 unknown function; putative glutamate synthase (NADPH) small subunit 4202611 gltD_1 6227677 gltD_1 Mycobacterium marinum M putative glutamate synthase (NADPH) small subunit YP_001851687.1 4200926 D 216594 CDS YP_001851688.1 183983397 6227678 4202608..4206189 1 NC_010612.1 function unknown; probably involved in cellular metabolism; pyruvate ferredoxin/flavodoxin oxidoreductase family protein 4206189 6227678 MMAR_3408 Mycobacterium marinum M pyruvate ferredoxin/flavodoxin oxidoreductase family protein YP_001851688.1 4202608 D 216594 CDS YP_001851689.1 183983398 6227679 4206189..4207199 1 NC_010612.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 4207199 6227679 MMAR_3409 Mycobacterium marinum M dihydroorotate dehydrogenase 2 YP_001851689.1 4206189 D 216594 CDS YP_001851690.1 183983399 6227680 4207227..4209632 1 NC_010612.1 role in pyruvate metabolism. reaction: ATP + pyruvate + H(2)O <=> AMP + phosphoenolpyruvate + phosphate; pyruvate dikinase 4209632 6227680 MMAR_3410 Mycobacterium marinum M pyruvate dikinase YP_001851690.1 4207227 D 216594 CDS YP_001851691.1 183983400 6227681 complement(4209643..4210776) 1 NC_010612.1 involved in glycolysis; converts sugar-1-P to sugar- 1,6-P [catalytic activity: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate]; 6-phosphofructokinase 4210776 pfkA_1 6227681 pfkA_1 Mycobacterium marinum M 6-phosphofructokinase YP_001851691.1 4209643 R 216594 CDS YP_001851692.1 183983401 6227682 complement(4210872..4211396) 1 NC_010612.1 hypothetical protein 4211396 6227682 MMAR_3412 Mycobacterium marinum M hypothetical protein YP_001851692.1 4210872 R 216594 CDS YP_001851693.1 183983402 6227683 4211498..4212883 1 NC_010612.1 function unknown; probably involved in cellular metabolism; oxidoreductase 4212883 6227683 MMAR_3413 Mycobacterium marinum M oxidoreductase YP_001851693.1 4211498 D 216594 CDS YP_001851694.1 183983403 6227684 complement(4212946..4213455) 1 NC_010612.1 hypothetical protein 4213455 6227684 MMAR_3414 Mycobacterium marinum M hypothetical protein YP_001851694.1 4212946 R 216594 CDS YP_001851695.1 183983404 6227685 4214400..4216019 1 NC_010612.1 involved in phosphate transport; phosphate-transport permease PitB 4216019 pitB 6227685 pitB Mycobacterium marinum M phosphate-transport permease PitB YP_001851695.1 4214400 D 216594 CDS YP_001851696.1 183983405 6227686 4216439..4218106 1 NC_010612.1 generates nitrite from ammonia using oxidized ferredoxin [catalytic activity: ammonia + H(2)O + oh(-) + 3 oxidized ferredoxin = nitrite + 3 reduced ferredoxin]. the sulfite reductases catalyze the reduction of sulfite to sulfide, one step in the biosynthesis of sulfur- containing amino acids and cofactors; ferredoxin-dependent nitrite/sulfite reductase NirA 4218106 nirA 6227686 nirA Mycobacterium marinum M ferredoxin-dependent nitrite/sulfite reductase NirA YP_001851696.1 4216439 D 216594 CDS YP_001851697.1 183983406 6227687 4218136..4218870 1 NC_010612.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 4218870 cysH_1 6227687 cysH_1 Mycobacterium marinum M phosphoadenosine phosphosulfate reductase YP_001851697.1 4218136 D 216594 CDS YP_001851698.1 183983407 6227688 4218867..4219586 1 NC_010612.1 hypothetical protein 4219586 6227688 MMAR_3418 Mycobacterium marinum M hypothetical protein YP_001851698.1 4218867 D 216594 CDS YP_001851699.1 183983408 6227689 complement(4219607..4220545) 1 NC_010612.1 LysR family transcriptional regulator 4220545 6227689 MMAR_3419 Mycobacterium marinum M LysR family transcriptional regulator YP_001851699.1 4219607 R 216594 CDS YP_001851700.1 183983409 6227690 4220632..4221996 1 NC_010612.1 generates oxidized ferredoxin from ferredoxin [catalytic activity: reduced ferredoxin + NADP(+) = oxidized ferredoxin + NADPH]; NADPH:adrenodoxin oxidoreductase FprA 4221996 fprA 6227690 fprA Mycobacterium marinum M NADPH:adrenodoxin oxidoreductase FprA YP_001851700.1 4220632 D 216594 CDS YP_001851701.1 183983410 6227691 4222019..4222345 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin FdxC 4222345 fdxC_1 6227691 fdxC_1 Mycobacterium marinum M ferredoxin FdxC YP_001851701.1 4222019 D 216594 CDS YP_001851702.1 183983411 6227692 4222810..4223601 1 NC_010612.1 hypothetical protein 4223601 6227692 MMAR_3422 Mycobacterium marinum M hypothetical protein YP_001851702.1 4222810 D 216594 CDS YP_001851703.1 183983412 6227693 complement(4224055..4224648) 1 NC_010612.1 function unknown. possibly involved in transcriptional mechanism; putative transcriptional regulatory protein 4224648 6227693 MMAR_3423 Mycobacterium marinum M putative transcriptional regulatory protein YP_001851703.1 4224055 R 216594 CDS YP_001851704.1 183983413 6227694 complement(4224833..4226197) 1 NC_010612.1 PE-PGRS family protein 4226197 6227694 MMAR_3424 Mycobacterium marinum M PE-PGRS family protein YP_001851704.1 4224833 R 216594 CDS YP_001851705.1 183983414 6227695 4226483..4227715 1 NC_010612.1 hypothetical protein 4227715 6227695 MMAR_3425 Mycobacterium marinum M hypothetical protein YP_001851705.1 4226483 D 216594 CDS YP_001851706.1 183983415 6227696 complement(4227724..4228542) 1 NC_010612.1 function unknown; contains putative acyltransferase domain; hypothetical protein 4228542 6227696 MMAR_3426 Mycobacterium marinum M hypothetical protein YP_001851706.1 4227724 R 216594 CDS YP_001851707.1 183983416 6227697 complement(4228833..4230482) 1 NC_010612.1 PE family protein 4230482 6227697 MMAR_3427 Mycobacterium marinum M PE family protein YP_001851707.1 4228833 R 216594 CDS YP_001851708.1 183983417 6227698 complement(4230917..4231288) 1 NC_010612.1 function unknown but contains zinc binding domain found at the N-terminus of the ClpX protein. ClpX is an ATPase which functions both as a substrate specificity component of the ClpXP protease and as a molecular chaperone; hypothetical protein 4231288 6227698 MMAR_3428 Mycobacterium marinum M hypothetical protein YP_001851708.1 4230917 R 216594 CDS YP_001851709.1 183983418 6227699 4231408..4232670 1 NC_010612.1 hydrolysis of lipids (bound ester); membrane-bound esterase LipM 4232670 lipM 6227699 lipM Mycobacterium marinum M membrane-bound esterase LipM YP_001851709.1 4231408 D 216594 CDS YP_001851710.1 183983419 6227700 4232667..4233668 1 NC_010612.1 hypothetical protein 4233668 6227700 MMAR_3430 Mycobacterium marinum M hypothetical protein YP_001851710.1 4232667 D 216594 CDS YP_001851711.1 183983420 6227701 4233857..4235197 1 NC_010612.1 hypothetical protein 4235197 6227701 MMAR_3431 Mycobacterium marinum M hypothetical protein YP_001851711.1 4233857 D 216594 CDS YP_001851712.1 183983421 6227702 complement(4235208..4236179) 1 NC_010612.1 transposition of of ISMyma04; transposase for ISMyma04 4236179 6227702 MMAR_3432 Mycobacterium marinum M transposase for ISMyma04 YP_001851712.1 4235208 R 216594 CDS YP_001851713.1 183983422 6227703 4236369..4237517 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 4237517 6227703 MMAR_3433 Mycobacterium marinum M oxidoreductase YP_001851713.1 4236369 D 216594 CDS YP_001851714.1 183983423 6227704 complement(4237523..4238215) 1 NC_010612.1 hypothetical protein 4238215 6227704 MMAR_3434 Mycobacterium marinum M hypothetical protein YP_001851714.1 4237523 R 216594 CDS YP_001851715.1 183983424 6227705 complement(4238360..4238800) 1 NC_010612.1 hypothetical protein 4238800 6227705 MMAR_3435 Mycobacterium marinum M hypothetical protein YP_001851715.1 4238360 R 216594 CDS YP_001851716.1 183983425 6227706 4239246..4240394 1 NC_010612.1 hypothetical protein 4240394 6227706 MMAR_3436 Mycobacterium marinum M hypothetical protein YP_001851716.1 4239246 D 216594 CDS YP_001851717.1 183983426 6227707 4240490..4242082 1 NC_010612.1 possibly involved in transport of Na+/H+ across the membrane; integral membrane transport protein YjcE 4242082 yjcE 6227707 yjcE Mycobacterium marinum M integral membrane transport protein YjcE YP_001851717.1 4240490 D 216594 CDS YP_001851718.1 183983427 6227708 4242145..4242795 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 4242795 6227708 MMAR_3438 Mycobacterium marinum M TetR family transcriptional regulator YP_001851718.1 4242145 D 216594 CDS YP_001851719.1 183983428 6227709 4242788..4244314 1 NC_010612.1 function unknown but contains identity with hydroxylase domain; hydroxylase 4244314 6227709 MMAR_3439 Mycobacterium marinum M hydroxylase YP_001851719.1 4242788 D 216594 CDS YP_001851720.1 183983429 6227710 4244398..4245264 1 NC_010612.1 function unknown but contains oxidoreductase domain; hypothetical protein 4245264 6227710 MMAR_3440 Mycobacterium marinum M hypothetical protein YP_001851720.1 4244398 D 216594 CDS YP_001851721.1 183983430 6227711 4245261..4245995 1 NC_010612.1 hypothetical protein 4245995 6227711 MMAR_3441 Mycobacterium marinum M hypothetical protein YP_001851721.1 4245261 D 216594 CDS YP_001851722.1 183983431 6227712 complement(4245989..4246327) 1 NC_010612.1 hypothetical protein 4246327 6227712 MMAR_3442 Mycobacterium marinum M hypothetical protein YP_001851722.1 4245989 R 216594 CDS YP_001851723.1 183983432 6227713 4247252..4248427 1 NC_010612.1 PPE family protein 4248427 6227713 MMAR_3443 Mycobacterium marinum M PPE family protein YP_001851723.1 4247252 D 216594 CDS YP_001851724.1 183983433 6227714 4248742..4249917 1 NC_010612.1 PPE family protein 4249917 6227714 MMAR_3444 Mycobacterium marinum M PPE family protein YP_001851724.1 4248742 D 216594 CDS YP_001851725.1 183983434 6227715 complement(4249993..4250787) 1 NC_010612.1 involved in phospholipid biosynthesis [catalytic activity: CDP-diacylglycerol + H(2)O = CMP + phosphatidate]; CDP-diacylglycerol pyrophosphatase 4250787 cdh 6227715 cdh Mycobacterium marinum M CDP-diacylglycerol pyrophosphatase YP_001851725.1 4249993 R 216594 CDS YP_001851726.1 183983435 6227716 complement(4250998..4251597) 1 NC_010612.1 hypothetical protein 4251597 6227716 MMAR_3446 Mycobacterium marinum M hypothetical protein YP_001851726.1 4250998 R 216594 CDS YP_001851727.1 183983436 6227717 complement(4251594..4252094) 1 NC_010612.1 hypothetical protein 4252094 6227717 MMAR_3447 Mycobacterium marinum M hypothetical protein YP_001851727.1 4251594 R 216594 CDS YP_001851728.1 183983437 6227718 4252100..4253434 1 NC_010612.1 hypothetical protein 4253434 6227718 MMAR_3448 Mycobacterium marinum M hypothetical protein YP_001851728.1 4252100 D 216594 CDS YP_001851729.1 183983438 6227719 4253481..4254482 1 NC_010612.1 hydrolase 4254482 6227719 MMAR_3449 Mycobacterium marinum M hydrolase YP_001851729.1 4253481 D 216594 CDS YP_001851730.1 183983439 6227720 complement(4254554..4254853) 1 NC_010612.1 hypothetical protein 4254853 6227720 MMAR_3450 Mycobacterium marinum M hypothetical protein YP_001851730.1 4254554 R 216594 CDS YP_001851731.1 183983440 6227721 4255276..4256142 1 NC_010612.1 hypothetical protein 4256142 6227721 MMAR_3451 Mycobacterium marinum M hypothetical protein YP_001851731.1 4255276 D 216594 CDS YP_001851732.1 183983441 6227722 4256405..4257484 1 NC_010612.1 hypothetical protein 4257484 6227722 MMAR_3452 Mycobacterium marinum M hypothetical protein YP_001851732.1 4256405 D 216594 CDS YP_001851733.1 183983442 6227723 4257552..4258751 1 NC_010612.1 aminotransferase 4258751 6227723 MMAR_3453 Mycobacterium marinum M aminotransferase YP_001851733.1 4257552 D 216594 CDS YP_001851734.1 183983443 6227724 complement(4258755..4259300) 1 NC_010612.1 putative regulatory protein 4259300 6227724 MMAR_3454 Mycobacterium marinum M putative regulatory protein YP_001851734.1 4258755 R 216594 CDS YP_001851735.1 183983444 6227725 4259409..4260281 1 NC_010612.1 hypothetical protein 4260281 6227725 MMAR_3455 Mycobacterium marinum M hypothetical protein YP_001851735.1 4259409 D 216594 CDS YP_001851736.1 183983445 6227726 complement(4260300..4261028) 1 NC_010612.1 could help control the pool of 3'-PHOSPHOADENOSIDE 5'-phosphosulfate, or its use in sulfite synthesis (by similarity); monophosphatase CysQ 4261028 cysQ_1 6227726 cysQ_1 Mycobacterium marinum M monophosphatase CysQ YP_001851736.1 4260300 R 216594 CDS YP_001851737.1 183983446 6227727 complement(4261130..4262308) 1 NC_010612.1 hypothetical protein 4262308 6227727 MMAR_3457 Mycobacterium marinum M hypothetical protein YP_001851737.1 4261130 R 216594 CDS YP_001851738.1 183983447 6227731 complement(4263984..4265408) 1 NC_010612.1 hypothetical protein 4265408 6227731 MMAR_3461 Mycobacterium marinum M hypothetical protein YP_001851738.1 4263984 R 216594 CDS YP_001851739.1 183983448 6227734 4267703..4267882 1 NC_010612.1 potential pseudogene; transposase 4267882 6227734 MMAR_3464 Mycobacterium marinum M transposase YP_001851739.1 4267703 D 216594 CDS YP_001851740.1 183983449 6227735 complement(4268538..4269680) 1 NC_010612.1 PPE family protein 4269680 6227735 MMAR_3465 Mycobacterium marinum M PPE family protein YP_001851740.1 4268538 R 216594 CDS YP_001851741.1 183983450 6227736 4270650..4271339 1 NC_010612.1 PPE family protein 4271339 6227736 MMAR_3466 Mycobacterium marinum M PPE family protein YP_001851741.1 4270650 D 216594 CDS YP_001851742.1 183983451 6227737 complement(4271575..4273302) 1 NC_010612.1 PE family protein 4273302 6227737 MMAR_3467 Mycobacterium marinum M PE family protein YP_001851742.1 4271575 R 216594 CDS YP_001851743.1 183983452 6227738 4273856..4274392 1 NC_010612.1 hypothetical protein 4274392 6227738 MMAR_3468 Mycobacterium marinum M hypothetical protein YP_001851743.1 4273856 D 216594 CDS YP_001851744.1 183983453 6227740 complement(4275073..4275858) 1 NC_010612.1 short chain membrane-associated dehydrogenase 4275858 6227740 MMAR_3470 Mycobacterium marinum M short chain membrane-associated dehydrogenase YP_001851744.1 4275073 R 216594 CDS YP_001851745.1 183983454 6227741 complement(4275868..4276302) 1 NC_010612.1 hypothetical protein 4276302 6227741 MMAR_3471 Mycobacterium marinum M hypothetical protein YP_001851745.1 4275868 R 216594 CDS YP_001851746.1 183983455 6227742 4276737..4277630 1 NC_010612.1 may act on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds [catalytic activity: 1-haloalkane + H(2)O, a primary alcohol + halide]; haloalkane dehalogenase 4277630 6227742 MMAR_3472 Mycobacterium marinum M haloalkane dehalogenase YP_001851746.1 4276737 D 216594 CDS YP_001851747.1 183983456 6227743 complement(4277637..4278530) 1 NC_010612.1 initiates the elongation in type II fatty acid synthase systems. elongation of fatty acids in the type II systems occurs by claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA; ketoacyl-acyl carrier protein synthase III 4278530 6227743 MMAR_3473 Mycobacterium marinum M ketoacyl-acyl carrier protein synthase III YP_001851747.1 4277637 R 216594 CDS YP_001851748.1 183983457 6227744 complement(4278514..4279614) 1 NC_010612.1 initiates the elongation in type II fatty acid synthase systems. elongation of fatty acids in the type II systems occurs by claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA; ketoacyl-acyl carrier protein synthase III 4279614 6227744 MMAR_3474 Mycobacterium marinum M ketoacyl-acyl carrier protein synthase III YP_001851748.1 4278514 R 216594 CDS YP_001851749.1 183983458 6227745 complement(4279643..4280632) 1 NC_010612.1 hypothetical protein 4280632 6227745 MMAR_3475 Mycobacterium marinum M hypothetical protein YP_001851749.1 4279643 R 216594 CDS YP_001851750.1 183983459 6227746 complement(4280736..4282184) 1 NC_010612.1 hypothetical protein 4282184 6227746 MMAR_3476 Mycobacterium marinum M hypothetical protein YP_001851750.1 4280736 R 216594 CDS YP_001851751.1 183983460 6227747 complement(4282316..4283212) 1 NC_010612.1 function unknown; contains universal stress protein UspA domain - possible nucleotide-binding protein invloved in signal transduction mechanism; hypothetical protein 4283212 6227747 MMAR_3477 Mycobacterium marinum M hypothetical protein YP_001851751.1 4282316 R 216594 CDS YP_001851752.1 183983461 6227748 4283515..4284330 1 NC_010612.1 function unknown. contains universal stress protein UspA domain - possible nucleotide-binding protein involved in signal transduction mechanisms; hypothetical protein 4284330 6227748 MMAR_3478 Mycobacterium marinum M hypothetical protein YP_001851752.1 4283515 D 216594 CDS YP_001851753.1 183983462 6227749 complement(4284352..4286001) 1 NC_010612.1 sensor part of a two-component regulatory system; two-component sensor histidine kinase 4286001 6227749 MMAR_3479 Mycobacterium marinum M two-component sensor histidine kinase YP_001851753.1 4284352 R 216594 CDS YP_001851754.1 183983463 6227750 complement(4286242..4286895) 1 NC_010612.1 regulator part of a two-component regulatory system; two-component transcriptional regulatory protein 4286895 6227750 MMAR_3480 Mycobacterium marinum M two-component transcriptional regulatory protein YP_001851754.1 4286242 R 216594 CDS YP_001851755.1 183983464 6227751 complement(4287104..4287868) 1 NC_010612.1 function unknown. could play a role in in the phosphorelay of the two-component regulatory system; hypothetical protein 4287868 6227751 MMAR_3481 Mycobacterium marinum M hypothetical protein YP_001851755.1 4287104 R 216594 CDS YP_001851756.1 183983465 6227752 complement(4288010..4288981) 1 NC_010612.1 phosphofructokinase and related sugar kinases play an important role in the predominant pathway for fructose utilisation; phosphofructokinase, PfkB 4288981 pfkB_1 6227752 pfkB_1 Mycobacterium marinum M phosphofructokinase, PfkB YP_001851756.1 4288010 R 216594 CDS YP_001851757.1 183983466 6227753 complement(4289010..4291052) 1 NC_010612.1 function unknown but contains N-term phosphoribosyltransferase domain and C-term eythromycin esterase; hypothetical protein 4291052 6227753 MMAR_3483 Mycobacterium marinum M hypothetical protein YP_001851757.1 4289010 R 216594 CDS YP_001851758.1 183983467 6227754 complement(4291071..4291502) 1 NC_010612.1 thought to be involved in the initiation step of translation at high temperature. bound to 30S ribosomal subunit. possibly a molecular chaperone. in M. tuberculosis H37Rv seems to be regulated positively by SigE and negatively by HspR; heat shock protein HspX 4291502 hspX_1 6227754 hspX_1 Mycobacterium marinum M heat shock protein HspX YP_001851758.1 4291071 R 216594 CDS YP_001851759.1 183983468 6227755 complement(4291698..4292024) 1 NC_010612.1 hypothetical protein 4292024 6227755 MMAR_3485 Mycobacterium marinum M hypothetical protein YP_001851759.1 4291698 R 216594 CDS YP_001851760.1 183983469 6227756 complement(4292151..4292423) 1 NC_010612.1 hypothetical protein 4292423 6227756 MMAR_3486 Mycobacterium marinum M hypothetical protein YP_001851760.1 4292151 R 216594 CDS YP_001851761.1 183983470 6227757 complement(4292633..4293613) 1 NC_010612.1 hypothetical protein 4293613 6227757 MMAR_3487 Mycobacterium marinum M hypothetical protein YP_001851761.1 4292633 R 216594 CDS YP_001851762.1 183983471 6227758 4293932..4295731 1 NC_010612.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4295731 acs_1 6227758 acs_1 Mycobacterium marinum M acetyl-CoA synthetase YP_001851762.1 4293932 D 216594 CDS YP_001851763.1 183983472 6227759 4295731..4296735 1 NC_010612.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component (alpha subunit) 4296735 6227759 MMAR_3489 Mycobacterium marinum M pyruvate dehydrogenase E1 component (alpha subunit) YP_001851763.1 4295731 D 216594 CDS YP_001851764.1 183983473 6227760 4296732..4297709 1 NC_010612.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component (beta subunit) 4297709 6227760 MMAR_3490 Mycobacterium marinum M pyruvate dehydrogenase E1 component (beta subunit) YP_001851764.1 4296732 D 216594 CDS YP_001851765.1 183983474 6227761 4297706..4298947 1 NC_010612.1 involved in tricarboxylic acid cycle; converts 2- oxoglutarate to succinyl-CoA and CO2; branched-chain alpha-keto acid dehydrogenase subunit E2 4298947 6227761 MMAR_3491 Mycobacterium marinum M branched-chain alpha-keto acid dehydrogenase subunit E2 YP_001851765.1 4297706 D 216594 CDS YP_001851766.1 183983475 6227762 4298955..4299212 1 NC_010612.1 function unknown; may act as an acyl carrier protein; hypothetical protein 4299212 6227762 MMAR_3492 Mycobacterium marinum M hypothetical protein YP_001851766.1 4298955 D 216594 CDS YP_001851767.1 183983476 6227763 4299314..4299733 1 NC_010612.1 hypothetical protein 4299733 6227763 MMAR_3493 Mycobacterium marinum M hypothetical protein YP_001851767.1 4299314 D 216594 CDS YP_001851768.1 183983477 6227764 4299906..4301507 1 NC_010612.1 function unknown; PE-PGRS family protein 4301507 6227764 MMAR_3494 Mycobacterium marinum M PE-PGRS family protein YP_001851768.1 4299906 D 216594 CDS YP_001851769.1 183983478 6227765 4301767..4302186 1 NC_010612.1 hypothetical protein 4302186 6227765 MMAR_3495 Mycobacterium marinum M hypothetical protein YP_001851769.1 4301767 D 216594 CDS YP_001851770.1 183983479 6227766 complement(4302197..4302670) 1 NC_010612.1 function unknown: homology to ,Fe-hydrogenase maturation factor; hypothetical protein 4302670 6227766 MMAR_3496 Mycobacterium marinum M hypothetical protein YP_001851770.1 4302197 R 216594 CDS YP_001851771.1 183983480 6227767 complement(4302667..4303959) 1 NC_010612.1 function unknown role in energy production and conversion; coenzyme F420-reducing hydrogenase subunit alpha 4303959 6227767 MMAR_3497 Mycobacterium marinum M coenzyme F420-reducing hydrogenase subunit alpha YP_001851771.1 4302667 R 216594 CDS YP_001851772.1 183983481 6227768 complement(4303959..4304714) 1 NC_010612.1 coenzyme F420-reducing hydrogenase subunit gamma 4304714 6227768 MMAR_3498 Mycobacterium marinum M coenzyme F420-reducing hydrogenase subunit gamma YP_001851772.1 4303959 R 216594 CDS YP_001851773.1 183983482 6227769 complement(4304715..4305572) 1 NC_010612.1 function unknown; involved in electron transfer; flavodoxin oxidoreductase 4305572 6227769 MMAR_3499 Mycobacterium marinum M flavodoxin oxidoreductase YP_001851773.1 4304715 R 216594 CDS YP_001851774.1 183983483 6227770 complement(4305565..4306695) 1 NC_010612.1 electron transfer; ferredoxin 4306695 6227770 MMAR_3500 Mycobacterium marinum M ferredoxin YP_001851774.1 4305565 R 216594 CDS YP_001851775.1 183983484 6227771 complement(4306787..4307368) 1 NC_010612.1 hypothetical protein 4307368 6227771 MMAR_3501 Mycobacterium marinum M hypothetical protein YP_001851775.1 4306787 R 216594 CDS YP_001851776.1 183983485 6227772 complement(4307430..4308431) 1 NC_010612.1 hypothetical protein 4308431 6227772 MMAR_3502 Mycobacterium marinum M hypothetical protein YP_001851776.1 4307430 R 216594 CDS YP_001851777.1 183983486 6227773 complement(4308580..4310913) 1 NC_010612.1 metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)]; metal cation transporter p-type ATPase 4310913 6227773 MMAR_3503 Mycobacterium marinum M metal cation transporter p-type ATPase YP_001851777.1 4308580 R 216594 CDS YP_001851778.1 183983487 6227774 complement(4311086..4311457) 1 NC_010612.1 hypothetical protein 4311457 6227774 MMAR_3504 Mycobacterium marinum M hypothetical protein YP_001851778.1 4311086 R 216594 CDS YP_001851779.1 183983488 6227775 4311592..4312929 1 NC_010612.1 function unknown; probably involved in cellular metabolism; hydrolase 4312929 6227775 MMAR_3505 Mycobacterium marinum M hydrolase YP_001851779.1 4311592 D 216594 CDS YP_001851780.1 183983489 6227776 complement(4312975..4313838) 1 NC_010612.1 hypothetical protein 4313838 6227776 MMAR_3506 Mycobacterium marinum M hypothetical protein YP_001851780.1 4312975 R 216594 CDS YP_001851781.1 183983490 6227777 4313967..4314866 1 NC_010612.1 involved in transcriptional mechanism; IclR family transcriptional regulator 4314866 6227777 MMAR_3507 Mycobacterium marinum M IclR family transcriptional regulator YP_001851781.1 4313967 D 216594 CDS YP_001851782.1 183983491 6227778 4315033..4315539 1 NC_010612.1 hypothetical protein 4315539 6227778 MMAR_3508 Mycobacterium marinum M hypothetical protein YP_001851782.1 4315033 D 216594 CDS YP_001851783.1 183983492 6227779 complement(4315576..4316289) 1 NC_010612.1 short-chain alcohol dehydrogenase 4316289 6227779 MMAR_3509 Mycobacterium marinum M short-chain alcohol dehydrogenase YP_001851783.1 4315576 R 216594 CDS YP_001851784.1 183983493 6227780 4316466..4317242 1 NC_010612.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_5 4317242 echA8_5 6227780 echA8_5 Mycobacterium marinum M enoyl-CoA hydratase, EchA8_5 YP_001851784.1 4316466 D 216594 CDS YP_001851785.1 183983494 6227781 4317227..4318393 1 NC_010612.1 acyl-CoA dehydrogenase 4318393 6227781 MMAR_3511 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001851785.1 4317227 D 216594 CDS YP_001851786.1 183983495 6227782 4318390..4319418 1 NC_010612.1 acyl-CoA dehydrogenase 4319418 6227782 MMAR_3512 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001851786.1 4318390 D 216594 CDS YP_001851787.1 183983496 6227783 complement(4319432..4320247) 1 NC_010612.1 cellular metabolism; oxidoreductase 4320247 6227783 MMAR_3513 Mycobacterium marinum M oxidoreductase YP_001851787.1 4319432 R 216594 CDS YP_001851788.1 183983497 6227784 complement(4320298..4321074) 1 NC_010612.1 function unknown, probably involved in cellular metabolism, possibly electron transfer; oxidoreductase 4321074 6227784 MMAR_3514 Mycobacterium marinum M oxidoreductase YP_001851788.1 4320298 R 216594 CDS YP_001851789.1 183983498 6227785 complement(4321262..4323406) 1 NC_010612.1 possibly involved in trehalose biosynthesis (protective effect). mycobacteria can produce trehalose from glucose 6-phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway); maltooligosyltrehalose synthase TreX 4323406 treX_1 6227785 treX_1 Mycobacterium marinum M maltooligosyltrehalose synthase TreX YP_001851789.1 4321262 R 216594 CDS YP_001851790.1 183983499 6227786 4323616..4324836 1 NC_010612.1 thought to be involved in fatty acid metabolism. generates octanol and oxidized rubredoxin from octane and reduced rubredoxin. also hydroxylates fatty acids in the omega-position [catalytic activity: octane + reduced rubredoxin + (O)2 = 1-octanol + oxidized rubredoxin + H(2)O]; transmembrane alkane 1-monooxygenase AlkB 4324836 alkB_1 6227786 alkB_1 Mycobacterium marinum M transmembrane alkane 1-monooxygenase AlkB YP_001851790.1 4323616 D 216594 CDS YP_001851791.1 183983500 6227787 4324833..4325003 1 NC_010612.1 involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase; rubredoxin RubA 4325003 rubA_1 6227787 rubA_1 Mycobacterium marinum M rubredoxin RubA YP_001851791.1 4324833 D 216594 CDS YP_001851792.1 183983501 6227788 4325005..4325190 1 NC_010612.1 involved in the hydrocarbon hydroxylating system to convert conversion of dodecane to lauric acid, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase; rubredoxin RubB 4325190 rubB_1 6227788 rubB_1 Mycobacterium marinum M rubredoxin RubB YP_001851792.1 4325005 D 216594 CDS YP_001851793.1 183983502 6227789 4325401..4326039 1 NC_010612.1 probably involved in a transcriptional mechanism; TetR family transcriptional regulator 4326039 6227789 MMAR_3519 Mycobacterium marinum M TetR family transcriptional regulator YP_001851793.1 4325401 D 216594 CDS YP_001851794.1 183983503 6227790 4326156..4327127 1 NC_010612.1 hypothetical protein 4327127 6227790 MMAR_3520 Mycobacterium marinum M hypothetical protein YP_001851794.1 4326156 D 216594 CDS YP_001851795.1 183983504 6227791 complement(4327128..4329074) 1 NC_010612.1 molecular chaperone; heat shock protein 90 4329074 htpG 6227791 htpG Mycobacterium marinum M heat shock protein 90 YP_001851795.1 4327128 R 216594 CDS YP_001851796.1 183983505 6227792 4329202..4331913 1 NC_010612.1 involved in transcriptional mechanism; LuxR family transcriptional regulator 4331913 6227792 MMAR_3522 Mycobacterium marinum M LuxR family transcriptional regulator YP_001851796.1 4329202 D 216594 CDS YP_001851797.1 183983506 6227793 complement(4331941..4332723) 1 NC_010612.1 hypothetical protein 4332723 6227793 MMAR_3523 Mycobacterium marinum M hypothetical protein YP_001851797.1 4331941 R 216594 CDS YP_001851798.1 183983507 6227794 4332888..4334096 1 NC_010612.1 hypothetical protein 4334096 6227794 MMAR_3524 Mycobacterium marinum M hypothetical protein YP_001851798.1 4332888 D 216594 CDS YP_001851799.1 183983508 6227795 complement(4334121..4334870) 1 NC_010612.1 function unknown but has domain identity to UbiE, a methylase involved in ubiquinone/menaquinone biosynthesis; methylase 4334870 6227795 MMAR_3525 Mycobacterium marinum M methylase YP_001851799.1 4334121 R 216594 CDS YP_001851800.1 183983509 6227796 4335037..4336086 1 NC_010612.1 function unknown but contains metal-dependant hydrolase domain identity; hypothetical protein 4336086 6227796 MMAR_3526 Mycobacterium marinum M hypothetical protein YP_001851800.1 4335037 D 216594 CDS YP_001851801.1 183983510 6227797 complement(4336116..4336409) 1 NC_010612.1 hypothetical protein 4336409 6227797 MMAR_3527 Mycobacterium marinum M hypothetical protein YP_001851801.1 4336116 R 216594 CDS YP_001851802.1 183983511 6227798 complement(4336543..4337091) 1 NC_010612.1 hypothetical protein 4337091 6227798 MMAR_3528 Mycobacterium marinum M hypothetical protein YP_001851802.1 4336543 R 216594 CDS YP_001851803.1 183983512 6227799 4337253..4338263 1 NC_010612.1 function unknown; probably involved in cellular metabolism; dehydrogenase 4338263 6227799 MMAR_3529 Mycobacterium marinum M dehydrogenase YP_001851803.1 4337253 D 216594 CDS YP_001851804.1 183983513 6227800 complement(4338315..4338743) 1 NC_010612.1 hypothetical protein 4338743 6227800 MMAR_3530 Mycobacterium marinum M hypothetical protein YP_001851804.1 4338315 R 216594 CDS YP_001851805.1 183983514 6227803 complement(4340680..4341315) 1 NC_010612.1 methyltransferase (methylase) 4341315 6227803 MMAR_3533 Mycobacterium marinum M methyltransferase (methylase) YP_001851805.1 4340680 R 216594 CDS YP_001851806.1 183983515 6227804 complement(4341312..4342244) 1 NC_010612.1 function unknown but high domain identity with O- Methyltransferases involved in polyketide biosynthesis; O-methyltransferase 4342244 6227804 MMAR_3534 Mycobacterium marinum M O-methyltransferase YP_001851806.1 4341312 R 216594 CDS YP_001851807.1 183983516 6227805 4342358..4342774 1 NC_010612.1 hypothetical protein 4342774 6227805 MMAR_3535 Mycobacterium marinum M hypothetical protein YP_001851807.1 4342358 D 216594 CDS YP_001851808.1 183983517 6227806 4342854..4343696 1 NC_010612.1 function unknown, but high domain identity with epimerases and phenazine biosynthesis-like protein, PhzC/PhzF which is involved in dimerisation of two 2,3- dihydro-3-oxo-anthranilic acid molecules to create Pca by P. fluorescens; hypothetical protein 4343696 6227806 MMAR_3536 Mycobacterium marinum M hypothetical protein YP_001851808.1 4342854 D 216594 CDS YP_001851809.1 183983518 6227807 complement(4343930..4345261) 1 NC_010612.1 hypothetical protein 4345261 6227807 MMAR_3537 Mycobacterium marinum M hypothetical protein YP_001851809.1 4343930 R 216594 CDS YP_001851810.1 183983519 6227808 complement(4345254..4347428) 1 NC_010612.1 hypothetical protein 4347428 6227808 MMAR_3538 Mycobacterium marinum M hypothetical protein YP_001851810.1 4345254 R 216594 CDS YP_001851811.1 183983520 6227809 4347509..4348291 1 NC_010612.1 function unknown but has ribonuclease I domain identity; hypothetical protein 4348291 6227809 MMAR_3539 Mycobacterium marinum M hypothetical protein YP_001851811.1 4347509 D 216594 CDS YP_001851812.1 183983521 6227810 4348831..4349457 1 NC_010612.1 hypothetical protein 4349457 6227810 MMAR_3540 Mycobacterium marinum M hypothetical protein YP_001851812.1 4348831 D 216594 CDS YP_001851813.1 183983522 6227811 4349511..4350230 1 NC_010612.1 conserved membrane protein of unknown function. similar to proteins from many organisms containing Cdd COG0398; uncharacterized conserved protein [function unknown]; hypothetical protein 4350230 6227811 MMAR_3541 Mycobacterium marinum M hypothetical protein YP_001851813.1 4349511 D 216594 CDS YP_001851814.1 183983523 6227812 4350333..4351463 1 NC_010612.1 function unknown but domain identity with mechanosensitive ion channels; hypothetical protein 4351463 6227812 MMAR_3542 Mycobacterium marinum M hypothetical protein YP_001851814.1 4350333 D 216594 CDS YP_001851815.1 183983524 6227813 complement(4351515..4354466) 1 NC_010612.1 function unknown but contains multiple functional domains including vWA domain (von willebrand factor (vWF) type a domain; found in extracellular proteins, like integrins, and mediates adhesion. also contains a vault protein inter-alpha-trypsin domain; hypothetical protein 4354466 6227813 MMAR_3543 Mycobacterium marinum M hypothetical protein YP_001851815.1 4351515 R 216594 CDS YP_001851816.1 183983525 6227814 4354531..4355313 1 NC_010612.1 hypothetical protein 4355313 6227814 MMAR_3544 Mycobacterium marinum M hypothetical protein YP_001851816.1 4354531 D 216594 CDS YP_001851817.1 183983526 6227815 4355362..4356501 1 NC_010612.1 involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB; transcriptional regulatory protein EmbR 4356501 embR_1 6227815 embR_1 Mycobacterium marinum M transcriptional regulatory protein EmbR YP_001851817.1 4355362 D 216594 CDS YP_001851818.1 183983527 6227816 complement(4356585..4358570) 1 NC_010612.1 PPE family protein 4358570 6227816 MMAR_3546 Mycobacterium marinum M PPE family protein YP_001851818.1 4356585 R 216594 CDS YP_001851819.1 183983528 6227817 4359376..4362492 1 NC_010612.1 involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]. N-term resembles PknK from MTB; serine/threonine-protein kinase transcriptional regulatory protein 4362492 6227817 MMAR_3547 Mycobacterium marinum M serine/threonine-protein kinase transcriptional regulatory protein YP_001851819.1 4359376 D 216594 CDS YP_001851820.1 183983529 6227818 4363068..4363862 1 NC_010612.1 hypothetical protein 4363862 6227818 MMAR_3548 Mycobacterium marinum M hypothetical protein YP_001851820.1 4363068 D 216594 CDS YP_001851821.1 183983530 6227819 4364261..4366438 1 NC_010612.1 function unknown but contains glutamine synthetase catalytic domain; hypothetical protein 4366438 6227819 MMAR_3549 Mycobacterium marinum M hypothetical protein YP_001851821.1 4364261 D 216594 CDS YP_001851822.1 183983531 6227820 complement(4366707..4367987) 1 NC_010612.1 PE-PGRS family protein 4367987 6227820 MMAR_3550 Mycobacterium marinum M PE-PGRS family protein YP_001851822.1 4366707 R 216594 CDS YP_001851823.1 183983532 6227821 4368447..4369025 1 NC_010612.1 proline, glycine, valine-rich secreted protein 4369025 6227821 MMAR_3551 Mycobacterium marinum M proline, glycine, valine-rich secreted protein YP_001851823.1 4368447 D 216594 CDS YP_001851824.1 183983533 6227822 complement(4369026..4369964) 1 NC_010612.1 hypothetical protein 4369964 6227822 MMAR_3552 Mycobacterium marinum M hypothetical protein YP_001851824.1 4369026 R 216594 CDS YP_001851825.1 183983534 6227823 4370312..4371070 1 NC_010612.1 function unknown, probably involved in cellular metabolism; alanine rich hydrolase 4371070 6227823 MMAR_3553 Mycobacterium marinum M alanine rich hydrolase YP_001851825.1 4370312 D 216594 CDS YP_001851826.1 183983535 6227824 complement(4371087..4372862) 1 NC_010612.1 function unknown. possibly transporter involved in transport of undeterminated substrate (possibly cationic amino acids) across the membrane: so responsible for the translocation of the substrate across the membrane; hypothetical protein 4372862 6227824 MMAR_3554 Mycobacterium marinum M hypothetical protein YP_001851826.1 4371087 R 216594 CDS YP_001851827.1 183983536 6227825 complement(4372946..4374163) 1 NC_010612.1 function unknown, high domain identity with saccharopine dehydrogenase. this family comprises three structural domains that can not be separated in the linear sequence. in some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate; saccharopine dehydrogenase 4374163 6227825 MMAR_3555 Mycobacterium marinum M saccharopine dehydrogenase YP_001851827.1 4372946 R 216594 CDS YP_001851828.1 183983537 6227826 complement(4374453..4375943) 1 NC_010612.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 4375943 6227826 MMAR_3556 Mycobacterium marinum M gamma-aminobutyraldehyde dehydrogenase YP_001851828.1 4374453 R 216594 CDS YP_001851829.1 183983538 6227827 4376065..4376580 1 NC_010612.1 involved in transcriptional mechanism; Lrp/AsnC family transcriptional regulator 4376580 6227827 MMAR_3557 Mycobacterium marinum M Lrp/AsnC family transcriptional regulator YP_001851829.1 4376065 D 216594 CDS YP_001851830.1 183983539 6227828 4376577..4377932 1 NC_010612.1 function unknown, high domain identity with BioA, aminotransferase [coenzyme metabolism]; hypothetical protein 4377932 6227828 MMAR_3558 Mycobacterium marinum M hypothetical protein YP_001851830.1 4376577 D 216594 CDS YP_001851831.1 183983540 6227829 complement(4378030..4378860) 1 NC_010612.1 function unknown - possible oxidoreducatse; hypothetical protein 4378860 6227829 MMAR_3559 Mycobacterium marinum M hypothetical protein YP_001851831.1 4378030 R 216594 CDS YP_001851832.1 183983541 6227830 complement(4378965..4379531) 1 NC_010612.1 possibly involved in transcriptional mechanism; transcriptional regulatory protein 4379531 6227830 MMAR_3560 Mycobacterium marinum M transcriptional regulatory protein YP_001851832.1 4378965 R 216594 CDS YP_001851833.1 183983542 6227831 4379646..4380491 1 NC_010612.1 function unknown, probably involved in cellular metabolism; short chain dehydrogenase 4380491 6227831 MMAR_3561 Mycobacterium marinum M short chain dehydrogenase YP_001851833.1 4379646 D 216594 CDS YP_001851834.1 183983543 6227832 4380522..4380950 1 NC_010612.1 hypothetical protein 4380950 6227832 MMAR_3562 Mycobacterium marinum M hypothetical protein YP_001851834.1 4380522 D 216594 CDS YP_001851835.1 183983544 6227833 complement(4380947..4381375) 1 NC_010612.1 rifampin ADP-ribosyl transferase 4381375 6227833 MMAR_3563 Mycobacterium marinum M rifampin ADP-ribosyl transferase YP_001851835.1 4380947 R 216594 CDS YP_001851836.1 183983545 6227834 complement(4381377..4382534) 1 NC_010612.1 catalyzes the one electron reduction of certain quinones [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone reductase, Qor 4382534 qor_1 6227834 qor_1 Mycobacterium marinum M quinone reductase, Qor YP_001851836.1 4381377 R 216594 CDS YP_001851837.1 183983546 6227835 4382638..4384074 1 NC_010612.1 hydrolyzes a monocarboxylic acid amide and generates a monocarboxylate [catalytic activity: a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)]; amidase 4384074 amiC_1 6227835 amiC_1 Mycobacterium marinum M amidase YP_001851837.1 4382638 D 216594 CDS YP_001851838.1 183983547 6227836 complement(4384117..4385682) 1 NC_010612.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB 4385682 plcB 6227836 plcB Mycobacterium marinum M membrane-associated phospholipase C2 PlcB YP_001851838.1 4384117 R 216594 CDS YP_001851839.1 183983548 6227837 4386332..4387381 1 NC_010612.1 hypothetical protein 4387381 6227837 MMAR_3568 Mycobacterium marinum M hypothetical protein YP_001851839.1 4386332 D 216594 CDS YP_001851840.1 183983549 6227838 complement(4387565..4387840) 1 NC_010612.1 hypothetical protein 4387840 6227838 MMAR_3569 Mycobacterium marinum M hypothetical protein YP_001851840.1 4387565 R 216594 CDS YP_001851841.1 183983550 6227839 4388079..4390853 1 NC_010612.1 PE-PGRS family protein 4390853 6227839 MMAR_3570 Mycobacterium marinum M PE-PGRS family protein YP_001851841.1 4388079 D 216594 CDS YP_001851842.1 183983551 6227840 4390998..4391291 1 NC_010612.1 hypothetical protein 4391291 6227840 MMAR_3571 Mycobacterium marinum M hypothetical protein YP_001851842.1 4390998 D 216594 CDS YP_001851843.1 183983552 6227841 4391295..4392200 1 NC_010612.1 hypothetical protein 4392200 6227841 MMAR_3572 Mycobacterium marinum M hypothetical protein YP_001851843.1 4391295 D 216594 CDS YP_001851844.1 183983553 6227842 4392197..4393141 1 NC_010612.1 hypothetical protein 4393141 6227842 MMAR_3573 Mycobacterium marinum M hypothetical protein YP_001851844.1 4392197 D 216594 CDS YP_001851845.1 183983554 6227843 complement(4394055..4394789) 1 NC_010612.1 hypothetical protein 4394789 6227843 MMAR_3574 Mycobacterium marinum M hypothetical protein YP_001851845.1 4394055 R 216594 CDS YP_001851846.1 183983555 6227844 complement(4395197..4396084) 1 NC_010612.1 function unknown; contains two OpuBC, periplasmic glycine betaine/choline-binding (LipO)protein domains of an ABC-type transport system (osmoprotectant binding protein); hypothetical protein 4396084 6227844 MMAR_3575 Mycobacterium marinum M hypothetical protein YP_001851846.1 4395197 R 216594 CDS YP_001851847.1 183983556 6227845 complement(4396088..4396873) 1 NC_010612.1 function unknown; domain identity with lactoylglutathione lyase; hypothetical protein 4396873 6227845 MMAR_3576 Mycobacterium marinum M hypothetical protein YP_001851847.1 4396088 R 216594 CDS YP_001851848.1 183983557 6227846 complement(4397066..4398097) 1 NC_010612.1 hypothetical protein 4398097 6227846 MMAR_3577 Mycobacterium marinum M hypothetical protein YP_001851848.1 4397066 R 216594 CDS YP_001851849.1 183983558 6227847 4399046..4400137 1 NC_010612.1 PPE family protein 4400137 6227847 MMAR_3578 Mycobacterium marinum M PPE family protein YP_001851849.1 4399046 D 216594 CDS YP_001851850.1 183983559 6227848 4400260..4400547 1 NC_010612.1 EsaT-6 like protein EsxK 4400547 esxK 6227848 esxK Mycobacterium marinum M EsaT-6 like protein EsxK YP_001851850.1 4400260 D 216594 CDS YP_001851851.1 183983560 6227849 4400665..4400949 1 NC_010612.1 EsaT-6 like protein EsxN_6 4400949 esxN_6 6227849 esxN_6 Mycobacterium marinum M EsaT-6 like protein EsxN_6 YP_001851851.1 4400665 D 216594 CDS YP_001851852.1 183983561 6227850 4401186..4403237 1 NC_010612.1 PE-PGRS family protein 4403237 6227850 MMAR_3581 Mycobacterium marinum M PE-PGRS family protein YP_001851852.1 4401186 D 216594 CDS YP_001851853.1 183983562 6227851 4403573..4403839 1 NC_010612.1 hypothetical protein 4403839 6227851 MMAR_3582 Mycobacterium marinum M hypothetical protein YP_001851853.1 4403573 D 216594 CDS YP_001851854.1 183983563 6227852 4404177..4404794 1 NC_010612.1 hypothetical protein 4404794 6227852 MMAR_3583 Mycobacterium marinum M hypothetical protein YP_001851854.1 4404177 D 216594 CDS YP_001851855.1 183983564 6227853 4404924..4405448 1 NC_010612.1 DNA integration. this sequence contains a DNA breaking-rejoining catalytic core found in phage integrase genes; phage-related integrase 4405448 6227853 MMAR_3584 Mycobacterium marinum M phage-related integrase YP_001851855.1 4404924 D 216594 CDS YP_001851856.1 183983565 6227854 4405461..4405673 1 NC_010612.1 phage-related integrase 4405673 6227854 MMAR_3585 Mycobacterium marinum M phage-related integrase YP_001851856.1 4405461 D 216594 CDS YP_001851857.1 183983566 6227855 4406071..4406700 1 NC_010612.1 hypothetical protein 4406700 6227855 MMAR_3586 Mycobacterium marinum M hypothetical protein YP_001851857.1 4406071 D 216594 CDS YP_001851858.1 183983567 6227856 4406697..4407458 1 NC_010612.1 hypothetical protein 4407458 6227856 MMAR_3587 Mycobacterium marinum M hypothetical protein YP_001851858.1 4406697 D 216594 CDS YP_001851859.1 183983568 6227857 4407496..4408092 1 NC_010612.1 hypothetical protein 4408092 6227857 MMAR_3588 Mycobacterium marinum M hypothetical protein YP_001851859.1 4407496 D 216594 CDS YP_001851860.1 183983569 6227860 complement(4409457..4409717) 1 NC_010612.1 hypothetical protein 4409717 6227860 MMAR_3591 Mycobacterium marinum M hypothetical protein YP_001851860.1 4409457 R 216594 CDS YP_001851861.1 183983570 6227861 complement(4409714..4409872) 1 NC_010612.1 hypothetical protein 4409872 6227861 MMAR_3592 Mycobacterium marinum M hypothetical protein YP_001851861.1 4409714 R 216594 CDS YP_001851862.1 183983571 6227862 4410127..4410423 1 NC_010612.1 hypothetical protein 4410423 6227862 MMAR_3593 Mycobacterium marinum M hypothetical protein YP_001851862.1 4410127 D 216594 CDS YP_001851863.1 183983572 6227863 4410875..4411483 1 NC_010612.1 hypothetical protein 4411483 6227863 MMAR_3594 Mycobacterium marinum M hypothetical protein YP_001851863.1 4410875 D 216594 CDS YP_001851864.1 183983573 6227864 4411480..4412331 1 NC_010612.1 hypothetical protein 4412331 6227864 MMAR_3595 Mycobacterium marinum M hypothetical protein YP_001851864.1 4411480 D 216594 CDS YP_001851865.1 183983574 6227865 4412684..4414411 1 NC_010612.1 hypothetical protein 4414411 6227865 MMAR_3596 Mycobacterium marinum M hypothetical protein YP_001851865.1 4412684 D 216594 CDS YP_001851866.1 183983575 6227866 4414512..4416110 1 NC_010612.1 may be part of a phage restriction modification system; ATP-dependent OLD family endonuclease 4416110 6227866 MMAR_3597 Mycobacterium marinum M ATP-dependent OLD family endonuclease YP_001851866.1 4414512 D 216594 CDS YP_001851867.1 183983576 6227867 4416097..4417131 1 NC_010612.1 may be involved in phage replication; helicase 4417131 6227867 MMAR_3598 Mycobacterium marinum M helicase YP_001851867.1 4416097 D 216594 CDS YP_001851868.1 183983577 6227868 complement(4417219..4420227) 1 NC_010612.1 involved in chromosome structure and partitioning. essential for chromosome partition. part of phage replication machinery; chromosome partition ATPase protein 4420227 6227868 MMAR_3599 Mycobacterium marinum M chromosome partition ATPase protein YP_001851868.1 4417219 R 216594 CDS YP_001851869.1 183983578 6227869 complement(4420224..4421456) 1 NC_010612.1 part of phage replication machinery; DNA repair exonuclease 4421456 6227869 MMAR_3600 Mycobacterium marinum M DNA repair exonuclease YP_001851869.1 4420224 R 216594 CDS YP_001851870.1 183983579 6227870 complement(4421453..4423267) 1 NC_010612.1 function unknown; may have ATPase activity; hypothetical protein 4423267 6227870 MMAR_3601 Mycobacterium marinum M hypothetical protein YP_001851870.1 4421453 R 216594 CDS YP_001851871.1 183983580 6227871 complement(4423281..4424261) 1 NC_010612.1 hypothetical protein 4424261 6227871 MMAR_3602 Mycobacterium marinum M hypothetical protein YP_001851871.1 4423281 R 216594 CDS YP_001851872.1 183983581 6227872 4424424..4424756 1 NC_010612.1 part of a plasmid or prophage maintenance system for killing segregants. weak identity with a putative killer suppression protein HigA from Methylococcus capsulatus str. Bath; killer suppression protein 4424756 6227872 MMAR_3603 Mycobacterium marinum M killer suppression protein YP_001851872.1 4424424 D 216594 CDS YP_001851873.1 183983582 6227873 4424778..4425872 1 NC_010612.1 ensures cells expressing the corresponding protein toxin are not killed; plasmid maintenance system antidote protein 4425872 6227873 MMAR_3604 Mycobacterium marinum M plasmid maintenance system antidote protein YP_001851873.1 4424778 D 216594 CDS YP_001851874.1 183983583 6227874 complement(4426055..4428859) 1 NC_010612.1 probably involved in phage replication. may play a role in DNA helix relaxation; ATP-dependent exoDNAse 4428859 6227874 MMAR_3605 Mycobacterium marinum M ATP-dependent exoDNAse YP_001851874.1 4426055 R 216594 CDS YP_001851875.1 183983584 6227875 4429273..4429479 1 NC_010612.1 hypothetical protein 4429479 6227875 MMAR_3606 Mycobacterium marinum M hypothetical protein YP_001851875.1 4429273 D 216594 CDS YP_001851876.1 183983585 6227876 4429513..4430775 1 NC_010612.1 DNA integration. this sequence contains a DNA breaking-rejoining catalytic core found in phage integrase genes; phage integrase 4430775 6227876 MMAR_3607 Mycobacterium marinum M phage integrase YP_001851876.1 4429513 D 216594 CDS YP_001851877.1 183983586 6227878 4431723..4432574 1 NC_010612.1 hypothetical protein 4432574 6227878 MMAR_3608 Mycobacterium marinum M hypothetical protein YP_001851877.1 4431723 D 216594 CDS YP_001851878.1 183983587 6227879 4432844..4433185 1 NC_010612.1 function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL4 4433185 mmpL4 6227879 mmpL4 Mycobacterium marinum M transmembrane transport protein MmpL4 YP_001851878.1 4432844 D 216594 CDS YP_001851879.1 183983588 6227880 4433559..4433993 1 NC_010612.1 hypothetical protein 4433993 6227880 MMAR_3610 Mycobacterium marinum M hypothetical protein YP_001851879.1 4433559 D 216594 CDS YP_001851880.1 183983589 6227881 complement(4434096..4434647) 1 NC_010612.1 hypothetical protein 4434647 6227881 MMAR_3611 Mycobacterium marinum M hypothetical protein YP_001851880.1 4434096 R 216594 CDS YP_001851881.1 183983590 6227882 4434864..4437476 1 NC_010612.1 metal cation-transporting ATPase; possibly catalyzes the transport of a undeterminated metal cation with the hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation transporter p-type ATPase a 4437476 6227882 MMAR_3612 Mycobacterium marinum M metal cation transporter p-type ATPase a YP_001851881.1 4434864 D 216594 CDS YP_001851882.1 183983591 6227883 complement(4437473..4437775) 1 NC_010612.1 hypothetical protein 4437775 6227883 MMAR_5561 Mycobacterium marinum M hypothetical protein YP_001851882.1 4437473 R 216594 CDS YP_001851883.1 183983592 6227884 complement(4437949..4438731) 1 NC_010612.1 hypothetical protein 4438731 6227884 MMAR_3613 Mycobacterium marinum M hypothetical protein YP_001851883.1 4437949 R 216594 CDS YP_001851884.1 183983593 6227885 complement(4438728..4439582) 1 NC_010612.1 hypothetical protein 4439582 6227885 MMAR_3614 Mycobacterium marinum M hypothetical protein YP_001851884.1 4438728 R 216594 CDS YP_001851885.1 183983594 6227886 complement(4439623..4440996) 1 NC_010612.1 hypothetical protein 4440996 6227886 MMAR_3615 Mycobacterium marinum M hypothetical protein YP_001851885.1 4439623 R 216594 CDS YP_001851886.1 183983595 6227887 complement(4440993..4442510) 1 NC_010612.1 hypothetical protein 4442510 6227887 MMAR_3616 Mycobacterium marinum M hypothetical protein YP_001851886.1 4440993 R 216594 CDS YP_001851887.1 183983596 6227888 4442545..4443417 1 NC_010612.1 thought to be involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane; sugar-transport integral membrane protein ABC transporter UspA 4443417 uspA 6227888 uspA Mycobacterium marinum M sugar-transport integral membrane protein ABC transporter UspA YP_001851887.1 4442545 D 216594 CDS YP_001851888.1 183983597 6227889 4443404..4444243 1 NC_010612.1 thought to be involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane; sugar-transport integral membrane protein ABC transporter UspB 4444243 uspB 6227889 uspB Mycobacterium marinum M sugar-transport integral membrane protein ABC transporter UspB YP_001851888.1 4443404 D 216594 CDS YP_001851889.1 183983598 6227890 4444240..4445568 1 NC_010612.1 thought to be involved in active transport of sugar across the membrane (import); periplasmic sugar-binding lipoprotein UspC 4445568 uspC 6227890 uspC Mycobacterium marinum M periplasmic sugar-binding lipoprotein UspC YP_001851889.1 4444240 D 216594 CDS YP_001851890.1 183983599 6227891 complement(4445599..4446471) 1 NC_010612.1 hypothetical protein 4446471 6227891 MMAR_3620 Mycobacterium marinum M hypothetical protein YP_001851890.1 4445599 R 216594 CDS YP_001851891.1 183983600 6227892 complement(4446468..4447937) 1 NC_010612.1 thought to be involved in transport of cationic amino acid (especially arginine and ornithine) across the membrane. responsible for the translocation of the substrate across the membrane; cationic amino acid transport integral membrane protein RocE 4447937 rocE 6227892 rocE Mycobacterium marinum M cationic amino acid transport integral membrane protein RocE YP_001851891.1 4446468 R 216594 CDS YP_001851892.1 183983601 6227893 complement(4447967..4449211) 1 NC_010612.1 involved in arginine metabolism [catalytic activity: L-ornithine + a 2-OXO acid = L-glutamate 5- semialdehyde + an L-amino acid]; ornithine aminotransferase RocD1 and RocD2 4449211 rocD 6227893 rocD Mycobacterium marinum M ornithine aminotransferase RocD1 and RocD2 YP_001851892.1 4447967 R 216594 CDS YP_001851893.1 183983602 6227894 complement(4449208..4450083) 1 NC_010612.1 hypothetical protein 4450083 6227894 MMAR_3623 Mycobacterium marinum M hypothetical protein YP_001851893.1 4449208 R 216594 CDS YP_001851894.1 183983603 6227895 4450207..4450659 1 NC_010612.1 involved in transcriptional mechanism; AsnC family transcriptional regulator 4450659 6227895 MMAR_3624 Mycobacterium marinum M AsnC family transcriptional regulator YP_001851894.1 4450207 D 216594 CDS YP_001851895.1 183983604 6227896 complement(4450656..4451516) 1 NC_010612.1 hypothetical protein 4451516 6227896 MMAR_3625 Mycobacterium marinum M hypothetical protein YP_001851895.1 4450656 R 216594 CDS YP_001851896.1 183983605 6227897 complement(4451513..4453585) 1 NC_010612.1 probably involved in active transport accross the membrane. thought to be responsible for energy coupling to the transport system and the translocation of the substrate across the membrane; transmembrane ATP-binding protein ABC transorter 4453585 6227897 MMAR_3626 Mycobacterium marinum M transmembrane ATP-binding protein ABC transorter YP_001851896.1 4451513 R 216594 CDS YP_001851897.1 183983606 6227898 4453704..4454180 1 NC_010612.1 hypothetical protein 4454180 6227898 MMAR_3627 Mycobacterium marinum M hypothetical protein YP_001851897.1 4453704 D 216594 CDS YP_001851898.1 183983607 6227899 4454347..4456866 1 NC_010612.1 thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 4456866 6227899 MMAR_3628 Mycobacterium marinum M transmembrane ABC transporter ATP-binding protein YP_001851898.1 4454347 D 216594 CDS YP_001851899.1 183983608 6227900 complement(4456839..4457999) 1 NC_010612.1 hypothetical protein 4457999 6227900 MMAR_3629 Mycobacterium marinum M hypothetical protein YP_001851899.1 4456839 R 216594 CDS YP_001851900.1 183983609 6227901 complement(4457996..4458730) 1 NC_010612.1 membrane protein 4458730 6227901 MMAR_3630 Mycobacterium marinum M membrane protein YP_001851900.1 4457996 R 216594 CDS YP_001851901.1 183983610 6227902 4458856..4460799 1 NC_010612.1 function unknown, but seems involved in metabolism of small branched-chain fatty acids and macrolide antibiotic production. catalyses the alpha, beta- dehydrogenetion of acyl-CoA esters and transfer electrons to ETF, the electron transfer protein; acyl-CoA dehydrogenase 4460799 6227902 MMAR_3631 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001851901.1 4458856 D 216594 CDS YP_001851902.1 183983611 6227903 complement(4460906..4462546) 1 NC_010612.1 tryptophan halogenase catalyses the chlorination of tryptophan to form 7-chlorotryptophan. this is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. tryptophan halogenase is NADH-dependent; tryptophan halogenase 4462546 6227903 MMAR_3632 Mycobacterium marinum M tryptophan halogenase YP_001851902.1 4460906 R 216594 CDS YP_001851903.1 183983612 6227904 complement(4462552..4462680) 1 NC_010612.1 hypothetical protein 4462680 6227904 MMAR_5573 Mycobacterium marinum M hypothetical protein YP_001851903.1 4462552 R 216594 CDS YP_001851904.1 183983613 6227905 4463193..4472699 1 NC_010612.1 function unknown but contains 3 modules for the potential synthesis of a tripeptide; peptide synthetase Nrp (peptide synthase) 4472699 6227905 MMAR_3633 Mycobacterium marinum M peptide synthetase Nrp (peptide synthase) YP_001851904.1 4463193 D 216594 CDS YP_001851905.1 183983614 6227906 4472719..4473276 1 NC_010612.1 function unknown; probably involved in cellular metabolism; oxidase 4473276 6227906 MMAR_3634 Mycobacterium marinum M oxidase YP_001851905.1 4472719 D 216594 CDS YP_001851906.1 183983615 6227907 4473351..4474646 1 NC_010612.1 probably involved in transport of undeterminated substrate (possibly cations Na/H) across the membrane. thought to be responsible for the translocation of the substrate across the membrane; integral membrane ion antiporter 4474646 6227907 MMAR_3635 Mycobacterium marinum M integral membrane ion antiporter YP_001851906.1 4473351 D 216594 CDS YP_001851907.1 183983616 6227908 4474722..4475495 1 NC_010612.1 function unknown but has domain identity to UbiE, a methylase involved in ubiquinone/menaquinone biosynthesis; methylase 4475495 6227908 MMAR_3636 Mycobacterium marinum M methylase YP_001851907.1 4474722 D 216594 CDS YP_001851908.1 183983617 6227909 complement(4475790..4477313) 1 NC_010612.1 involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; integral membrane nitrite extrusion protein NarK1 4477313 narK1 6227909 narK1 Mycobacterium marinum M integral membrane nitrite extrusion protein NarK1 YP_001851908.1 4475790 R 216594 CDS YP_001851909.1 183983618 6227910 complement(4477537..4478040) 1 NC_010612.1 lipoprotein LppP 4478040 lppP 6227910 lppP Mycobacterium marinum M lipoprotein LppP YP_001851909.1 4477537 R 216594 CDS YP_001851910.1 183983619 6227911 4478460..4482668 1 NC_010612.1 decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors [catalytic activity: formate + NAD(+) = CO(2) + NADH]; formate dehydrogenase H FdhF 4482668 fdhF 6227911 fdhF Mycobacterium marinum M formate dehydrogenase H FdhF YP_001851910.1 4478460 D 216594 CDS YP_001851911.1 183983620 6227912 4482993..4484921 1 NC_010612.1 thought to play an essential roles in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'- cyclic AMP + pyrophosphate]; adenylate cyclase 4484921 6227912 MMAR_3640 Mycobacterium marinum M adenylate cyclase YP_001851911.1 4482993 D 216594 CDS YP_001851912.1 183983621 6227913 4485827..4487188 1 NC_010612.1 PPE family protein 4487188 6227913 MMAR_3641 Mycobacterium marinum M PPE family protein YP_001851912.1 4485827 D 216594 CDS YP_001851913.1 183983622 6227914 complement(4487502..4489058) 1 NC_010612.1 thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane; integral membrane transport protein 4489058 6227914 MMAR_3642 Mycobacterium marinum M integral membrane transport protein YP_001851913.1 4487502 R 216594 CDS YP_001851914.1 183983623 6227915 4489474..4491120 1 NC_010612.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 4491120 mez 6227915 mez Mycobacterium marinum M malate dehydrogenase YP_001851914.1 4489474 D 216594 CDS YP_001851915.1 183983624 6227916 4491428..4491844 1 NC_010612.1 hypothetical protein 4491844 6227916 MMAR_3644 Mycobacterium marinum M hypothetical protein YP_001851915.1 4491428 D 216594 CDS YP_001851916.1 183983625 6227917 4491841..4492773 1 NC_010612.1 involved in cysteine biosynthesis [catalytic activity: O3-acetyl-L-serine + H(2)S = L-cysteine + acetate]; cysteine synthase a CysK1 4492773 cysK1 6227917 cysK1 Mycobacterium marinum M cysteine synthase a CysK1 YP_001851916.1 4491841 D 216594 CDS YP_001851917.1 183983626 6227918 4492770..4493462 1 NC_010612.1 involved in cysteine biosynthesis [catalytic activity: acetyl-CoA + L-serine = CoA + O-acetyl-L- serine]; serine acetyltransferase CysE 4493462 cysE 6227918 cysE Mycobacterium marinum M serine acetyltransferase CysE YP_001851917.1 4492770 D 216594 CDS YP_001851918.1 183983627 6227919 4493473..4493901 1 NC_010612.1 thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions; thioredoxin ThiX 4493901 thiX 6227919 thiX Mycobacterium marinum M thioredoxin ThiX YP_001851918.1 4493473 D 216594 CDS YP_001851919.1 183983628 6227920 4493929..4494381 1 NC_010612.1 function unknown, contains N-term signal peptide indicative of secreted protein; hypothetical protein 4494381 6227920 MMAR_3648 Mycobacterium marinum M hypothetical protein YP_001851919.1 4493929 D 216594 CDS YP_001851920.1 183983629 6227922 4494748..4494993 1 NC_010612.1 hypothetical protein 4494993 6227922 MMAR_3649 Mycobacterium marinum M hypothetical protein YP_001851920.1 4494748 D 216594 CDS YP_001851921.1 183983630 6227923 complement(4495008..4496978) 1 NC_010612.1 synthesizes RNA primers at the replication forks; DNA primase 4496978 dnaG 6227923 dnaG Mycobacterium marinum M DNA primase YP_001851921.1 4495008 R 216594 CDS YP_001851922.1 183983631 6227924 complement(4497020..4498390) 1 NC_010612.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 4498390 dgt 6227924 dgt Mycobacterium marinum M deoxyguanosinetriphosphate triphosphohydrolase-like protein YP_001851922.1 4497020 R 216594 CDS YP_001851923.1 183983632 6227925 4498441..4500429 1 NC_010612.1 hypothetical protein 4500429 6227925 MMAR_3652 Mycobacterium marinum M hypothetical protein YP_001851923.1 4498441 D 216594 CDS YP_001851924.1 183983633 6227926 complement(4500638..4500922) 1 NC_010612.1 EsaT-6 like protein EsxN_3 4500922 esxN_3 6227926 esxN_3 Mycobacterium marinum M EsaT-6 like protein EsxN_3 YP_001851924.1 4500638 R 216594 CDS YP_001851925.1 183983634 6227927 complement(4500985..4501281) 1 NC_010612.1 EsaT-6 like protein EsxP_2 4501281 esxP_2 6227927 esxP_2 Mycobacterium marinum M EsaT-6 like protein EsxP_2 YP_001851925.1 4500985 R 216594 CDS YP_001851926.1 183983635 6227928 complement(4501414..4501731) 1 NC_010612.1 hypothetical protein 4501731 6227928 MMAR_3655 Mycobacterium marinum M hypothetical protein YP_001851926.1 4501414 R 216594 CDS YP_001851927.1 183983636 6227929 complement(4502018..4503568) 1 NC_010612.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB 4503568 plcB_5 6227929 plcB_5 Mycobacterium marinum M membrane-associated phospholipase C2 PlcB YP_001851927.1 4502018 R 216594 CDS YP_001851928.1 183983637 6227930 complement(4503965..4505527) 1 NC_010612.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB 4505527 plcB_4 6227930 plcB_4 Mycobacterium marinum M membrane-associated phospholipase C2 PlcB YP_001851928.1 4503965 R 216594 CDS YP_001851929.1 183983638 6227931 4506113..4506901 1 NC_010612.1 hypothetical protein 4506901 6227931 MMAR_3658 Mycobacterium marinum M hypothetical protein YP_001851929.1 4506113 D 216594 CDS YP_001851930.1 183983639 6227932 complement(4507101..4507385) 1 NC_010612.1 EsaT-6 like protein EsxN_4 4507385 esxN_4 6227932 esxN_4 Mycobacterium marinum M EsaT-6 like protein EsxN_4 YP_001851930.1 4507101 R 216594 CDS YP_001851931.1 183983640 6227933 complement(4507400..4507696) 1 NC_010612.1 EsaT-6 like protein EsxP_3 4507696 esxP_3 6227933 esxP_3 Mycobacterium marinum M EsaT-6 like protein EsxP_3 YP_001851931.1 4507400 R 216594 CDS YP_001851932.1 183983641 6227934 complement(4507776..4508939) 1 NC_010612.1 PPE family protein 4508939 6227934 MMAR_3661 Mycobacterium marinum M PPE family protein YP_001851932.1 4507776 R 216594 CDS YP_001851933.1 183983642 6227935 complement(4509214..4509498) 1 NC_010612.1 EsaT-6 like protein EsxN_5 4509498 esxN_5 6227935 esxN_5 Mycobacterium marinum M EsaT-6 like protein EsxN_5 YP_001851933.1 4509214 R 216594 CDS YP_001851934.1 183983643 6227936 complement(4509513..4509809) 1 NC_010612.1 EsaT-6 like protein EsxP_4 4509809 esxP_4 6227936 esxP_4 Mycobacterium marinum M EsaT-6 like protein EsxP_4 YP_001851934.1 4509513 R 216594 CDS YP_001851935.1 183983644 6227937 complement(4509889..4511055) 1 NC_010612.1 PPE family protein 4511055 6227937 MMAR_3664 Mycobacterium marinum M PPE family protein YP_001851935.1 4509889 R 216594 CDS YP_001851936.1 183983645 6227938 complement(4511619..4513529) 1 NC_010612.1 PPE family protein 4513529 6227938 MMAR_3665 Mycobacterium marinum M PPE family protein YP_001851936.1 4511619 R 216594 CDS YP_001851937.1 183983646 6227939 complement(4513819..4515744) 1 NC_010612.1 PPE family protein 4515744 6227939 MMAR_3666 Mycobacterium marinum M PPE family protein YP_001851937.1 4513819 R 216594 CDS YP_001851938.1 183983647 6227940 complement(4515981..4517372) 1 NC_010612.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase 4517372 glyS 6227940 glyS Mycobacterium marinum M glycyl-tRNA synthetase YP_001851938.1 4515981 R 216594 CDS YP_001851939.1 183983648 6227941 4517566..4517961 1 NC_010612.1 involved in transcriptional mechanism; ArsR family transcriptional regulator 4517961 6227941 MMAR_3668 Mycobacterium marinum M ArsR family transcriptional regulator YP_001851939.1 4517566 D 216594 CDS YP_001851940.1 183983649 6227942 4517958..4518371 1 NC_010612.1 acts as a global negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes; Zinc uptake regulation protein Zur 4518371 zur 6227942 zur Mycobacterium marinum M Zinc uptake regulation protein Zur YP_001851940.1 4517958 D 216594 CDS YP_001851941.1 183983650 6227943 complement(4518368..4518808) 1 NC_010612.1 hypothetical protein 4518808 6227943 MMAR_3670 Mycobacterium marinum M hypothetical protein YP_001851941.1 4518368 R 216594 CDS YP_001851942.1 183983651 6227944 complement(4518808..4519698) 1 NC_010612.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 4519698 6227944 MMAR_3671 Mycobacterium marinum M undecaprenyl pyrophosphate synthase YP_001851942.1 4518808 R 216594 CDS YP_001851943.1 183983652 6227945 complement(4519691..4520488) 1 NC_010612.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 4520488 recO 6227945 recO Mycobacterium marinum M DNA repair protein RecO YP_001851943.1 4519691 R 216594 CDS YP_001851944.1 183983653 6227946 4520550..4522049 1 NC_010612.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 4522049 amiA2 6227946 amiA2 Mycobacterium marinum M amidase YP_001851944.1 4520550 D 216594 CDS YP_001851945.1 183983654 6227947 complement(4522046..4522948) 1 NC_010612.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 4522948 era 6227947 era Mycobacterium marinum M GTP-binding protein Era YP_001851945.1 4522046 R 216594 CDS YP_001851946.1 183983655 6227948 complement(4522938..4523168) 1 NC_010612.1 hypothetical protein 4523168 6227948 MMAR_3675 Mycobacterium marinum M hypothetical protein YP_001851946.1 4522938 R 216594 CDS YP_001851947.1 183983656 6227949 complement(4523137..4524459) 1 NC_010612.1 hypothetical protein 4524459 6227949 MMAR_3676 Mycobacterium marinum M hypothetical protein YP_001851947.1 4523137 R 216594 CDS YP_001851948.1 183983657 6227950 complement(4524456..4524992) 1 NC_010612.1 putative metalloprotease 4524992 6227950 MMAR_3677 Mycobacterium marinum M putative metalloprotease YP_001851948.1 4524456 R 216594 CDS YP_001851949.1 183983658 6227951 complement(4525011..4526069) 1 NC_010612.1 PhoH-like protein PhoH1 4526069 phoH1 6227951 phoH1 Mycobacterium marinum M PhoH-like protein PhoH1 YP_001851949.1 4525011 R 216594 CDS YP_001851950.1 183983659 6227952 complement(4526137..4526835) 1 NC_010612.1 function unknown but contains tetracycline repressor-like C-terminal superfamily domain; putative regulatory protein 4526835 6227952 MMAR_3679 Mycobacterium marinum M putative regulatory protein YP_001851950.1 4526137 R 216594 CDS YP_001851951.1 183983660 6227953 4526863..4527759 1 NC_010612.1 function unknown but contains alpha/beta-hydrolase superfamily domain; hypothetical protein 4527759 6227953 MMAR_3680 Mycobacterium marinum M hypothetical protein YP_001851951.1 4526863 D 216594 CDS YP_001851952.1 183983661 6227954 4527847..4528386 1 NC_010612.1 hypothetical protein 4528386 6227954 MMAR_3681 Mycobacterium marinum M hypothetical protein YP_001851952.1 4527847 D 216594 CDS YP_001851953.1 183983662 6227955 complement(4528409..4529170) 1 NC_010612.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 4529170 6227955 MMAR_3682 Mycobacterium marinum M 16S ribosomal RNA methyltransferase RsmE YP_001851953.1 4528409 R 216594 CDS YP_001851954.1 183983663 6227956 complement(4529199..4530335) 1 NC_010612.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 4530335 dnaJ2 6227956 dnaJ2 Mycobacterium marinum M chaperone protein DnaJ YP_001851954.1 4529199 R 216594 CDS YP_001851955.1 183983664 6227957 complement(4530410..4531441) 1 NC_010612.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 4531441 hrcA 6227957 hrcA Mycobacterium marinum M heat-inducible transcription repressor YP_001851955.1 4530410 R 216594 CDS YP_001851956.1 183983665 6227958 4531714..4532028 1 NC_010612.1 hypothetical protein 4532028 6227958 MMAR_3685 Mycobacterium marinum M hypothetical protein YP_001851956.1 4531714 D 216594 CDS YP_001851957.1 183983666 6227959 4532123..4532722 1 NC_010612.1 function unknown but contains identity with antioxidant defence protein Ahp; hypothetical protein 4532722 6227959 MMAR_3686 Mycobacterium marinum M hypothetical protein YP_001851957.1 4532123 D 216594 CDS YP_001851958.1 183983667 6227960 4532719..4533618 1 NC_010612.1 the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. belongs to the sigma-70 factor family, ECF subfamily; alternative RNA polymerase sigma factor SigJ-like protein 4533618 6227960 MMAR_3687 Mycobacterium marinum M alternative RNA polymerase sigma factor SigJ-like protein YP_001851958.1 4532719 D 216594 CDS YP_001851959.1 183983668 6227961 complement(4533656..4534165) 1 NC_010612.1 function not known (putative secreted protein); may play a role in the development of protective immune responses; low molecular weight antigen Cfp2 4534165 cfp2 6227961 cfp2 Mycobacterium marinum M low molecular weight antigen Cfp2 YP_001851959.1 4533656 R 216594 CDS YP_001851960.1 183983669 6227962 complement(4534449..4537940) 1 NC_010612.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. this peptide synthase forms amide bound between the carboxylic acid of salicylate and the alpha-amino group of serine (serine/threonine ligation); phenyloxazoline synthase MbtB 4537940 mbtB 6227962 mbtB Mycobacterium marinum M phenyloxazoline synthase MbtB YP_001851960.1 4534449 R 216594 CDS YP_001851961.1 183983670 6227963 complement(4537976..4542514) 1 NC_010612.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. activates amino acid residues that are incorporated into mycobactin (ligation); non-ribosomal peptide synthetase MbtF 4542514 mbtF 6227963 mbtF Mycobacterium marinum M non-ribosomal peptide synthetase MbtF YP_001851961.1 4537976 R 216594 CDS YP_001851962.1 183983671 6227964 complement(4542511..4547523) 1 NC_010612.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. probably activates the two lysine residues that are incorporated into mycobactin (lysine ligation); non-ribosomal peptide synthetase MbtE 4547523 mbtE 6227964 mbtE Mycobacterium marinum M non-ribosomal peptide synthetase MbtE YP_001851962.1 4542511 R 216594 CDS YP_001851963.1 183983672 6227965 4547798..4548403 1 NC_010612.1 function unknown but contains acyl-CoA N- acetyltransferase superfamily domain; hypothetical protein 4548403 6227965 MMAR_3692 Mycobacterium marinum M hypothetical protein YP_001851963.1 4547798 D 216594 CDS YP_001851964.1 183983673 6227966 4548513..4549271 1 NC_010612.1 may be required for the addition of the terminal aa in this Nrp operon; thioesterase 4549271 6227966 MMAR_3693 Mycobacterium marinum M thioesterase YP_001851964.1 4548513 D 216594 CDS YP_001851965.1 183983674 6227967 4549268..4550587 1 NC_010612.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins; polyketide synthase MbtC 4550587 mbtC 6227967 mbtC Mycobacterium marinum M polyketide synthase MbtC YP_001851965.1 4549268 D 216594 CDS YP_001851966.1 183983675 6227968 4550584..4553658 1 NC_010612.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins; polyketide synthase MbtD 4553658 mbtD 6227968 mbtD Mycobacterium marinum M polyketide synthase MbtD YP_001851966.1 4550584 D 216594 CDS YP_001851967.1 183983676 6227969 complement(4553663..4553878) 1 NC_010612.1 thought to be involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins; hypothetical protein 4553878 mbtH_1 6227969 mbtH_1 Mycobacterium marinum M hypothetical protein YP_001851967.1 4553663 R 216594 CDS YP_001851968.1 183983677 6227970 complement(4553859..4555268) 1 NC_010612.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. this hydroxylase is possibly required for N-hydroxylation of the two lysine residues at some stage during mycobactin assembly [catalytic activity: L-lysine + O(2) = N6-hydroxy- L-lysine + H(2)O. no information can be found if this enzyme is NADPH dependent or independent]; lysine-N-oxygenase MbtG 4555268 mbtG 6227970 mbtG Mycobacterium marinum M lysine-N-oxygenase MbtG YP_001851968.1 4553859 R 216594 CDS YP_001851969.1 183983678 6227971 4555360..4557012 1 NC_010612.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins (initiation step of mycobactin chain growth). activates the mycobactin ACP in two half-reactions: activates salicylic acid as acyladenylate (adenylation step) + transfers activated salicylate to the MbtA ACP as a thioester (arylation step); bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 4557012 mbtA 6227971 mbtA Mycobacterium marinum M bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase YP_001851969.1 4555360 D 216594 CDS YP_001851970.1 183983679 6227972 4557131..4558126 1 NC_010612.1 involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. possibly required for N-hydroxylation of the two lysine residues at some stage during mycobactin assembly; acetyl hydrolase MbtJ 4558126 mbtJ 6227972 mbtJ Mycobacterium marinum M acetyl hydrolase MbtJ YP_001851970.1 4557131 D 216594 CDS YP_001851971.1 183983680 6227973 4558128..4558988 1 NC_010612.1 short-chain membrane-associated dehydrogenase 4558988 6227973 MMAR_3700 Mycobacterium marinum M short-chain membrane-associated dehydrogenase YP_001851971.1 4558128 D 216594 CDS YP_001851972.1 183983681 6227974 4559020..4559940 1 NC_010612.1 function unknown but contains ferritin/ribonucleotide reductase-like superfamily domain; putative reductase 4559940 6227974 MMAR_3701 Mycobacterium marinum M putative reductase YP_001851972.1 4559020 D 216594 CDS YP_001851973.1 183983682 6227975 4559937..4561448 1 NC_010612.1 function unknown; involved in cellular metabolism; flavin-binding monooxygenase 4561448 6227975 MMAR_3702 Mycobacterium marinum M flavin-binding monooxygenase YP_001851973.1 4559937 D 216594 CDS YP_001851974.1 183983683 6227976 4561445..4562407 1 NC_010612.1 function unknown. possibly involved in transcriptional mechanism; putative transcriptional regulator 4562407 6227976 MMAR_3703 Mycobacterium marinum M putative transcriptional regulator YP_001851974.1 4561445 D 216594 CDS YP_001851975.1 183983684 6227977 complement(4562439..4563455) 1 NC_010612.1 catalyzes the principal conversion of saturated fatty acids to unsaturated fatty acids. thought to convert stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons delta-9 and delta-10 of the acyl chain [catalytic activity: stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + a + 2 H2O]; acyl-[acyl-carrier protein] desaturase DesA1 4563455 desA1_1 6227977 desA1_1 Mycobacterium marinum M acyl-[acyl-carrier protein] desaturase DesA1 YP_001851975.1 4562439 R 216594 CDS YP_001851976.1 183983685 6227978 complement(4563525..4564328) 1 NC_010612.1 hypothetical protein 4564328 6227978 MMAR_3705 Mycobacterium marinum M hypothetical protein YP_001851976.1 4563525 R 216594 CDS YP_001851977.1 183983686 6227979 complement(4564529..4565887) 1 NC_010612.1 catalyzes conversion of chorismate to salicylate, in mycobactin siderophore construction; requires Mg(2+) for function; salicylate synthase MbtI 4565887 mbtI 6227979 mbtI Mycobacterium marinum M salicylate synthase MbtI YP_001851977.1 4564529 R 216594 CDS YP_001851978.1 183983687 6227980 4566280..4566489 1 NC_010612.1 hypothetical protein 4566489 6227980 MMAR_3707 Mycobacterium marinum M hypothetical protein YP_001851978.1 4566280 D 216594 CDS YP_001851979.1 183983688 6227981 4566779..4568014 1 NC_010612.1 membrane permease 4568014 6227981 MMAR_3708 Mycobacterium marinum M membrane permease YP_001851979.1 4566779 D 216594 CDS YP_001851980.1 183983689 6227982 complement(4568026..4569198) 1 NC_010612.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4569198 hemN 6227982 hemN Mycobacterium marinum M coproporphyrinogen III oxidase YP_001851980.1 4568026 R 216594 CDS YP_001851981.1 183983690 6227983 4569636..4571303 1 NC_010612.1 generates nitrite from ammonia using oxidized ferredoxin [catalytic activity: ammonia + H(2)O + oh(-) + 3 oxidized ferredoxin = nitrite + 3 reduced ferredoxin]. can also act as a sulphite reductase. the sulfite reductases catalyze the reduction of sulfite to sulfide, one step in the biosynthesis of sulfur-containing amino acids and cofactors. this appears to be the only intact nitrite reductase in M. ulcerans; ferredoxin-dependent nitrite/sulfite reductase NirA 4571303 nirA_2 6227983 nirA_2 Mycobacterium marinum M ferredoxin-dependent nitrite/sulfite reductase NirA YP_001851981.1 4569636 D 216594 CDS YP_001851982.1 183983691 6227984 4571300..4572049 1 NC_010612.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 4572049 cysH 6227984 cysH Mycobacterium marinum M phosphoadenosine phosphosulfate reductase YP_001851982.1 4571300 D 216594 CDS YP_001851983.1 183983692 6227985 4572046..4572759 1 NC_010612.1 function unknown but contains a chelatase superfamily domain. given the presence of other heme- associated CDS in this region and the presence of a chelatase superfamily domain, this CDS may encode a ferrochelatase, catalyzing the last step in HemE biosynthesis; hypothetical protein 4572759 6227985 MMAR_3712 Mycobacterium marinum M hypothetical protein YP_001851983.1 4572046 D 216594 CDS YP_001851984.1 183983693 6227986 4572774..4574714 1 NC_010612.1 plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione [catalytic activity: 5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid]; gamma-glutamyltranspeptidase 4574714 ggtB 6227986 ggtB Mycobacterium marinum M gamma-glutamyltranspeptidase YP_001851984.1 4572774 D 216594 CDS YP_001851985.1 183983694 6227987 4574806..4576809 1 NC_010612.1 function unknown but domain identity suggests a role in transporting oligopeptides as signals across the membrane; hypothetical protein 4576809 6227987 MMAR_3714 Mycobacterium marinum M hypothetical protein YP_001851985.1 4574806 D 216594 CDS YP_001851986.1 183983695 6227988 complement(4576838..4577947) 1 NC_010612.1 involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import). responsible for energy coupling to the transport system; sulfate-transport ABC transporter ATP-binding protein CysA1 4577947 cysA1 6227988 cysA1 Mycobacterium marinum M sulfate-transport ABC transporter ATP-binding protein CysA1 YP_001851986.1 4576838 R 216594 CDS YP_001851987.1 183983696 6227989 complement(4577944..4578762) 1 NC_010612.1 involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import). responsible for the translocation of the substrate across the membrane; sulfate-transport integral membrane protein ABC transporter CysW 4578762 cysW 6227989 cysW Mycobacterium marinum M sulfate-transport integral membrane protein ABC transporter CysW YP_001851987.1 4577944 R 216594 CDS YP_001851988.1 183983697 6227990 complement(4578759..4579661) 1 NC_010612.1 involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import). responsible for the translocation of the substrate across the membrane; sulfate-transport integral membrane protein ABC transporter CysT 4579661 cysT 6227990 cysT Mycobacterium marinum M sulfate-transport integral membrane protein ABC transporter CysT YP_001851988.1 4578759 R 216594 CDS YP_001851989.1 183983698 6227991 complement(4579658..4580707) 1 NC_010612.1 involved in the active transport across the membrane of multiple sulfur-containing compounds, including sulfate and thiosulfate (import); sulfate-binding lipoprotein SubI 4580707 subI 6227991 subI Mycobacterium marinum M sulfate-binding lipoprotein SubI YP_001851989.1 4579658 R 216594 CDS YP_001851990.1 183983699 6227992 complement(4581057..4581251) 1 NC_010612.1 hypothetical protein 4581251 6227992 MMAR_3719 Mycobacterium marinum M hypothetical protein YP_001851990.1 4581057 R 216594 CDS YP_001851991.1 183983700 6227993 4581387..4582565 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hypothetical protein 4582565 6227993 MMAR_3720 Mycobacterium marinum M hypothetical protein YP_001851991.1 4581387 D 216594 CDS YP_001851992.1 183983701 6227994 4582636..4584702 1 NC_010612.1 glycosyl hydrolase 4584702 6227994 MMAR_3721 Mycobacterium marinum M glycosyl hydrolase YP_001851992.1 4582636 D 216594 CDS YP_001851993.1 183983702 6227995 complement(4584720..4585493) 1 NC_010612.1 lipoprotein LppR 4585493 lppR 6227995 lppR Mycobacterium marinum M lipoprotein LppR YP_001851993.1 4584720 R 216594 CDS YP_001851994.1 183983703 6227996 complement(4585493..4586236) 1 NC_010612.1 lipoprotein LppR 4586236 lppR_1 6227996 lppR_1 Mycobacterium marinum M lipoprotein LppR YP_001851994.1 4585493 R 216594 CDS YP_001851995.1 183983704 6227997 complement(4586239..4588155) 1 NC_010612.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 4588155 lepA 6227997 lepA Mycobacterium marinum M GTP-binding protein LepA YP_001851995.1 4586239 R 216594 CDS YP_001851996.1 183983705 6227998 4588189..4588791 1 NC_010612.1 function unknown but domain identity with plasmid maintenance toxin superfamily; hypothetical protein 4588791 6227998 MMAR_3725 Mycobacterium marinum M hypothetical protein YP_001851996.1 4588189 D 216594 CDS YP_001851997.1 183983706 6227999 complement(4588833..4589261) 1 NC_010612.1 function unknown but contains 2 Cbs domains; transcriptional regulator 4589261 6227999 MMAR_3726 Mycobacterium marinum M transcriptional regulator YP_001851997.1 4588833 R 216594 CDS YP_001851998.1 183983707 6228000 4589487..4590326 1 NC_010612.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 4590326 6228000 MMAR_3727 Mycobacterium marinum M ribonuclease Z YP_001851998.1 4589487 D 216594 CDS YP_001851999.1 183983708 6228001 4590489..4592093 1 NC_010612.1 PE-PGRS family protein 4592093 6228001 MMAR_3728 Mycobacterium marinum M PE-PGRS family protein YP_001851999.1 4590489 D 216594 CDS YP_001852000.1 183983709 6228002 4592197..4593624 1 NC_010612.1 PE-PGRS family protein 4593624 6228002 MMAR_3729 Mycobacterium marinum M PE-PGRS family protein YP_001852000.1 4592197 D 216594 CDS YP_001852001.1 183983710 6228003 complement(4593629..4594468) 1 NC_010612.1 function unknown but based on domain identity it may cross-link proteins through an acyl-transfer reaction between the gamma-carboxamide group of peptide-bound glutamine and the epsilon-amino group of peptide-bound lysine; putative transglutaminase-like protein 4594468 6228003 MMAR_3730 Mycobacterium marinum M putative transglutaminase-like protein YP_001852001.1 4593629 R 216594 CDS YP_001852002.1 183983711 6228004 complement(4594468..4595445) 1 NC_010612.1 hypothetical protein 4595445 6228004 MMAR_3731 Mycobacterium marinum M hypothetical protein YP_001852002.1 4594468 R 216594 CDS YP_001852003.1 183983712 6228005 complement(4595445..4597118) 1 NC_010612.1 function unknown but contains two glutathione synthetase ATP-binding superfamily domain-like sequences; hypothetical protein 4597118 6228005 MMAR_3732 Mycobacterium marinum M hypothetical protein YP_001852003.1 4595445 R 216594 CDS YP_001852004.1 183983713 6228006 4597257..4597520 1 NC_010612.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 4597520 rpsT 6228006 rpsT Mycobacterium marinum M 30S ribosomal protein S20 YP_001852004.1 4597257 D 216594 CDS YP_001852005.1 183983714 6228007 complement(4597593..4598570) 1 NC_010612.1 possible role in DNA replication. two superfamily domains detected. N-term contains P-loop nucleoside triphosphate hydrolase. C-term contains DNA polymerase III, delta subunit; hypothetical protein 4598570 holA 6228007 holA Mycobacterium marinum M hypothetical protein YP_001852005.1 4597593 R 216594 CDS YP_001852006.1 183983715 6228008 complement(4598583..4600148) 1 NC_010612.1 function unknown, predicted membrane metal-binding protein; membrane metal-binding protein ComEC 4600148 comEC 6228008 comEC Mycobacterium marinum M membrane metal-binding protein ComEC YP_001852006.1 4598583 R 216594 CDS YP_001852007.1 183983716 6228009 complement(4600166..4601041) 1 NC_010612.1 function unknown but domain identity suggests ComEA. a family of DNA uptake protein and related DNA- binding proteins involved in DNA replication, recombination, and repair; membrane protein ComEA 4601041 comEA 6228009 comEA Mycobacterium marinum M membrane protein ComEA YP_001852007.1 4600166 R 216594 CDS YP_001852008.1 183983717 6228010 4601296..4602462 1 NC_010612.1 function unknown, but probable involvement in lipid metabolism; acyl-CoA dehydrogenase FadE17 4602462 fadE17_1 6228010 fadE17_1 Mycobacterium marinum M acyl-CoA dehydrogenase FadE17 YP_001852008.1 4601296 D 216594 CDS YP_001852009.1 183983718 6228011 4602470..4603588 1 NC_010612.1 function unknown, but supposed involvement in lipid metabolism; acyl-CoA dehydrogenase FadE18 4603588 fadE18_2 6228011 fadE18_2 Mycobacterium marinum M acyl-CoA dehydrogenase FadE18 YP_001852009.1 4602470 D 216594 CDS YP_001852010.1 183983719 6228012 4603844..4604944 1 NC_010612.1 function unknown but contains FAD/NAD(P)-binding superfamily domain; hypothetical protein 4604944 6228012 MMAR_3739 Mycobacterium marinum M hypothetical protein YP_001852010.1 4603844 D 216594 CDS YP_001852011.1 183983720 6228013 complement(4605167..4606360) 1 NC_010612.1 supposed involved in intracellular survival. possibly associated with the cell surface and secreted; hypothetical protein 4606360 eis 6228013 eis Mycobacterium marinum M hypothetical protein YP_001852011.1 4605167 R 216594 CDS YP_001852012.1 183983721 6228014 4606490..4607539 1 NC_010612.1 function unknown but contains superfamily NAD(P)- binding Rossmann-fold domains; hypothetical protein 4607539 6228014 MMAR_3741 Mycobacterium marinum M hypothetical protein YP_001852012.1 4606490 D 216594 CDS YP_001852013.1 183983722 6228015 4607542..4608318 1 NC_010612.1 hypothetical protein 4608318 6228015 MMAR_3742 Mycobacterium marinum M hypothetical protein YP_001852013.1 4607542 D 216594 CDS YP_001852014.1 183983723 6228016 4608634..4609077 1 NC_010612.1 membrane protein MmpS5 4609077 mmpS5_1 6228016 mmpS5_1 Mycobacterium marinum M membrane protein MmpS5 YP_001852014.1 4608634 D 216594 CDS YP_001852015.1 183983724 6228017 4609074..4611995 1 NC_010612.1 function unknown. thought to be involved in lipid transport; transmembrane transport protein MmpL 4611995 mmpL4_1 6228017 mmpL4_1 Mycobacterium marinum M transmembrane transport protein MmpL YP_001852015.1 4609074 D 216594 CDS YP_001852016.1 183983725 6228018 complement(4612031..4612876) 1 NC_010612.1 function unknown, contains DegV-like superfamily domain; hypothetical protein 4612876 6228018 MMAR_3745 Mycobacterium marinum M hypothetical protein YP_001852016.1 4612031 R 216594 CDS YP_001852017.1 183983726 6228019 complement(4612880..4613635) 1 NC_010612.1 function unknown but contains esterase/acetylhydrolase superfamily domain; hypothetical protein 4613635 6228019 MMAR_3746 Mycobacterium marinum M hypothetical protein YP_001852017.1 4612880 R 216594 CDS YP_001852018.1 183983727 6228020 complement(4613625..4614299) 1 NC_010612.1 involved in glycolysis [catalytic activity: 2- phosphoglycerate + 2,3-diphosphoglycerate = 3- phosphoglycerate + 2,3-diphosphoglycerate]; phosphoglycerate mutase 4614299 gpm_1 6228020 gpm_1 Mycobacterium marinum M phosphoglycerate mutase YP_001852018.1 4613625 R 216594 CDS YP_001852019.1 183983728 6228021 complement(4614296..4614685) 1 NC_010612.1 hypothetical protein 4614685 6228021 MMAR_3748 Mycobacterium marinum M hypothetical protein YP_001852019.1 4614296 R 216594 CDS YP_001852020.1 183983729 6228022 complement(4614682..4615329) 1 NC_010612.1 involved in NAD biosynthesis; catalyzes the reversible adenylation of nicotinate mononucleotide [catalytic activity: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD(+)]; nicotinate-nucleotide adenylyltransferase NadD 4615329 nadD 6228022 nadD Mycobacterium marinum M nicotinate-nucleotide adenylyltransferase NadD YP_001852020.1 4614682 R 216594 CDS YP_001852021.1 183983730 6228023 4615565..4616602 1 NC_010612.1 hypothetical protein 4616602 6228023 MMAR_3750 Mycobacterium marinum M hypothetical protein YP_001852021.1 4615565 D 216594 CDS YP_001852022.1 183983731 6228024 complement(4616613..4618052) 1 NC_010612.1 function unknown but contains a von willebrand factor type a conserved domain; hypothetical protein 4618052 6228024 MMAR_3751 Mycobacterium marinum M hypothetical protein YP_001852022.1 4616613 R 216594 CDS YP_001852023.1 183983732 6228025 complement(4618066..4618941) 1 NC_010612.1 function unknown but contains aaa ATPase domain containing von willebrand factor type a (vWA) domain; hypothetical protein 4618941 6228025 MMAR_3752 Mycobacterium marinum M hypothetical protein YP_001852023.1 4618066 R 216594 CDS YP_001852024.1 183983733 6228026 complement(4618975..4620246) 1 NC_010612.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 4620246 proA 6228026 proA Mycobacterium marinum M gamma-glutamyl phosphate reductase YP_001852024.1 4618975 R 216594 CDS YP_001852025.1 183983734 6228027 complement(4620338..4621732) 1 NC_010612.1 hypothetical protein 4621732 6228027 MMAR_3754 Mycobacterium marinum M hypothetical protein YP_001852025.1 4620338 R 216594 CDS YP_001852026.1 183983735 6228028 complement(4621729..4623921) 1 NC_010612.1 generates 3,'5'-cyclic (A/G)mp and diphosphate (or pyrophosphate) from (A/G)tp; adenylate or guanylate cyclase 4623921 6228028 MMAR_3755 Mycobacterium marinum M adenylate or guanylate cyclase YP_001852026.1 4621729 R 216594 CDS YP_001852027.1 183983736 6228029 complement(4624087..4625487) 1 NC_010612.1 function unknown but domain identity suggests that it may be a mechanosensitive (ms) ion channel protein with a C-term putative cyclic nucleotide (camp or cGMP) binding domain; hypothetical protein 4625487 6228029 MMAR_3756 Mycobacterium marinum M hypothetical protein YP_001852027.1 4624087 R 216594 CDS YP_001852028.1 183983737 6228030 complement(4625484..4627643) 1 NC_010612.1 generates 3,'5'-cyclic (A/G)mp and diphosphate (or pyrophosphate) from (A/G)tp; adenylate or guanylate cyclase 4627643 6228030 MMAR_3757 Mycobacterium marinum M adenylate or guanylate cyclase YP_001852028.1 4625484 R 216594 CDS YP_001852029.1 183983738 6228031 4628393..4630975 1 NC_010612.1 PE-PGRS family protein 4630975 6228031 MMAR_3758 Mycobacterium marinum M PE-PGRS family protein YP_001852029.1 4628393 D 216594 CDS YP_001852030.1 183983739 6228032 complement(4631088..4633130) 1 NC_010612.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 4633130 nadE 6228032 nadE Mycobacterium marinum M NAD synthetase YP_001852030.1 4631088 R 216594 CDS YP_001852031.1 183983740 6228033 4633422..4634291 1 NC_010612.1 function unknown, involved in transcriptional mechanism; Sir2-like regulatory protein 4634291 6228033 MMAR_3760 Mycobacterium marinum M Sir2-like regulatory protein YP_001852031.1 4633422 D 216594 CDS YP_001852032.1 183983741 6228034 complement(4634378..4635637) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 268A2 Cyp268A2 4635637 cyp268A2 6228034 cyp268A2 Mycobacterium marinum M cytochrome P450 268A2 Cyp268A2 YP_001852032.1 4634378 R 216594 CDS YP_001852033.1 183983742 6228035 4635766..4636404 1 NC_010612.1 function unknown. possibly involved in transcriptional mechanism; AcrR family transcriptional regulator 4636404 6228035 MMAR_3762 Mycobacterium marinum M AcrR family transcriptional regulator YP_001852033.1 4635766 D 216594 CDS YP_001852034.1 183983743 6228036 complement(4636475..4641919) 1 NC_010612.1 PE-PGRS family protein 4641919 6228036 MMAR_3763 Mycobacterium marinum M PE-PGRS family protein YP_001852034.1 4636475 R 216594 CDS YP_001852035.1 183983744 6228037 complement(4642271..4643377) 1 NC_010612.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 4643377 proB 6228037 proB Mycobacterium marinum M gamma-glutamyl kinase YP_001852035.1 4642271 R 216594 CDS YP_001852036.1 183983745 6228038 complement(4643377..4644816) 1 NC_010612.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 4644816 obgE 6228038 obgE Mycobacterium marinum M GTPase ObgE YP_001852036.1 4643377 R 216594 CDS YP_001852037.1 183983746 6228039 complement(4644920..4645186) 1 NC_010612.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 4645186 rpmA 6228039 rpmA Mycobacterium marinum M 50S ribosomal protein L27 YP_001852037.1 4644920 R 216594 CDS YP_001852038.1 183983747 6228040 complement(4645204..4645515) 1 NC_010612.1 involved in translation mechanisms; 50S ribosomal protein L21 4645515 rplU 6228040 rplU Mycobacterium marinum M 50S ribosomal protein L21 YP_001852038.1 4645204 R 216594 CDS YP_001852039.1 183983748 6228041 complement(4645788..4648841) 1 NC_010612.1 thought to be involved in several cellular process; ribonuclease E Rne 4648841 rne 6228041 rne Mycobacterium marinum M ribonuclease E Rne YP_001852039.1 4645788 R 216594 CDS YP_001852040.1 183983749 6228042 complement(4649168..4649578) 1 NC_010612.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 4649578 ndk 6228042 ndk Mycobacterium marinum M nucleoside diphosphate kinase YP_001852040.1 4649168 R 216594 CDS YP_001852041.1 183983750 6228043 complement(4649642..4650046) 1 NC_010612.1 hypothetical protein 4650046 6228043 MMAR_3770 Mycobacterium marinum M hypothetical protein YP_001852041.1 4649642 R 216594 CDS YP_001852042.1 183983751 6228044 complement(4650043..4651497) 1 NC_010612.1 conversion of folates to polyglutamate derivatives. bacteria require folate for the biosynthesis of glycine, methionine, formyl-met-tRNA, thymidylates, purines, and pantothenate [catalytic activity: ATP + {tetrahydrofolyl- [Glu]}(N) + L-glutamate = ADP + phosphate + {tetrahydrofolyl-[Glu]}(n+1)]; folylpolyglutamate synthase protein FolC 4651497 folC 6228044 folC Mycobacterium marinum M folylpolyglutamate synthase protein FolC YP_001852042.1 4650043 R 216594 CDS YP_001852043.1 183983752 6228045 complement(4651494..4654154) 1 NC_010612.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 4654154 valS 6228045 valS Mycobacterium marinum M valyl-tRNA synthetase YP_001852043.1 4651494 R 216594 CDS YP_001852044.1 183983753 6228046 complement(4654229..4654858) 1 NC_010612.1 function unknown but N-term contains a bulb-type mannose-specific lectin and C-term contains a LysM, a putative peptidoglycan-binding domain; hypothetical protein 4654858 6228046 MMAR_3773 Mycobacterium marinum M hypothetical protein YP_001852044.1 4654229 R 216594 CDS YP_001852045.1 183983754 6228047 complement(4654936..4655532) 1 NC_010612.1 hypothetical protein 4655532 6228047 MMAR_3774 Mycobacterium marinum M hypothetical protein YP_001852045.1 4654936 R 216594 CDS YP_001852046.1 183983755 6228048 complement(4655640..4656896) 1 NC_010612.1 function unknown but contains potential saccharopine-like dehydrogenase domain; hypothetical protein 4656896 6228048 MMAR_3775 Mycobacterium marinum M hypothetical protein YP_001852046.1 4655640 R 216594 CDS YP_001852047.1 183983756 6228049 complement(4657063..4657794) 1 NC_010612.1 thought to promote the resuscitation and growth of dormant, nongrowing cells. could also stimulate the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis; resuscitation-promoting factor RpfE 4657794 rpfE 6228049 rpfE Mycobacterium marinum M resuscitation-promoting factor RpfE YP_001852047.1 4657063 R 216594 CDS YP_001852048.1 183983757 6228051 complement(4659014..4659874) 1 NC_010612.1 flavin-dependent oxidoreductase 4659874 6228051 MMAR_3778 Mycobacterium marinum M flavin-dependent oxidoreductase YP_001852048.1 4659014 R 216594 CDS YP_001852049.1 183983758 6228052 complement(4659984..4668914) 1 NC_010612.1 production of unknown peptide. Predict 3 modules with domain structure (C-A-M-T, C-A-T, C); non-ribosomal peptide synthetase 4668914 6228052 MMAR_3779 Mycobacterium marinum M non-ribosomal peptide synthetase YP_001852049.1 4659984 R 216594 CDS YP_001852050.1 183983759 6228053 complement(4669337..4670821) 1 NC_010612.1 monooxygenase 4670821 6228053 MMAR_3780 Mycobacterium marinum M monooxygenase YP_001852050.1 4669337 R 216594 CDS YP_001852051.1 183983760 6228055 complement(4671921..4673126) 1 NC_010612.1 Single copy element; transposition of an insertion sequence (IS110 family); transposase 4673126 6228055 MMAR_3782 Mycobacterium marinum M transposase YP_001852051.1 4671921 R 216594 CDS YP_001852052.1 183983761 6228057 complement(4674145..4674966) 1 NC_010612.1 Single copy element; transposition of an ISMyma01-like element; transposase, ISMyma01_aa2-like protein 4674966 6228057 MMAR_3784 Mycobacterium marinum M transposase, ISMyma01_aa2-like protein YP_001852052.1 4674145 R 216594 CDS YP_001852053.1 183983762 6228058 complement(4674996..4675283) 1 NC_010612.1 transposition of an ISMyma01-like element; transposase, ISMyma01_aa1-like protein 4675283 6228058 MMAR_3785 Mycobacterium marinum M transposase, ISMyma01_aa1-like protein YP_001852053.1 4674996 R 216594 CDS YP_001852054.1 183983763 6228059 4675406..4676575 1 NC_010612.1 Single copy element; transposition of an IS3 family insertion sequence; transposase 4676575 6228059 MMAR_3786 Mycobacterium marinum M transposase YP_001852054.1 4675406 D 216594 CDS YP_001852055.1 183983764 6228060 4676588..4676863 1 NC_010612.1 hypothetical protein 4676863 6228060 MMAR_3787 Mycobacterium marinum M hypothetical protein YP_001852055.1 4676588 D 216594 CDS YP_001852056.1 183983765 6228062 complement(4677602..4678402) 1 NC_010612.1 function unknown but this protein family are hydrolase enzymes - isochorismatase is an enzyme that catalyzes the conversion of isochorismate to 2,3- dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond; isochorismatase family protein 4678402 6228062 MMAR_3790 Mycobacterium marinum M isochorismatase family protein YP_001852056.1 4677602 R 216594 CDS YP_001852057.1 183983766 6228064 4679594..4680643 1 NC_010612.1 single copy element; transposition of an IS110 family insertion sequence; transposase 4680643 6228064 MMAR_3792 Mycobacterium marinum M transposase YP_001852057.1 4679594 D 216594 CDS YP_001852058.1 183983767 6228065 complement(4680623..4680955) 1 NC_010612.1 single copy element. maybe a partial IS as C-term subunit tranposase is absent.; transposition of an insertion sequence; transposase 4680955 6228065 MMAR_3793 Mycobacterium marinum M transposase YP_001852058.1 4680623 R 216594 CDS YP_001852059.1 183983768 6228066 complement(4681054..4681728) 1 NC_010612.1 transcriptional regulatory protein 4681728 6228066 MMAR_3794 Mycobacterium marinum M transcriptional regulatory protein YP_001852059.1 4681054 R 216594 CDS YP_001852060.1 183983769 6228067 complement(4681990..4683639) 1 NC_010612.1 thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]; adenylate cyclase 4683639 6228067 MMAR_3795 Mycobacterium marinum M adenylate cyclase YP_001852060.1 4681990 R 216594 CDS YP_001852061.1 183983770 6228068 4685825..4691278 1 NC_010612.1 polyketide synthase involved in lipid synthesis. single extension module, domain arrangement: KS, Ata, DH, KR, ACP; type I modular polyketide synthase 4691278 6228068 MMAR_3796 Mycobacterium marinum M type I modular polyketide synthase YP_001852061.1 4685825 D 216594 CDS YP_001852062.1 183983771 6228069 4691294..4696897 1 NC_010612.1 polyketide synthase involved in lipid synthesis. single extension module, domain arrangement: KS, ATP, DH, KR, ACP; type I modular polyketide synthase 4696897 6228069 MMAR_3797 Mycobacterium marinum M type I modular polyketide synthase YP_001852062.1 4691294 D 216594 CDS YP_001852063.1 183983772 6228070 4696935..4713422 1 NC_010612.1 polyketide synthase involved in lipid synthesis. three extension modules, domain arrangement: KS, Ata, DH, ER, KR, ACP; KS ATP, KR, ACP; KS ATP, DH, KR, ACP; type I modular polyketide synthase 4713422 6228070 MMAR_3798 Mycobacterium marinum M type I modular polyketide synthase YP_001852063.1 4696935 D 216594 CDS YP_001852064.1 183983773 6228071 4713412..4719519 1 NC_010612.1 polyketide synthase involved in lipid synthesis. single extension module, domain arrangement: KS, Ata, DH, KR, ACP; type I modular polyketide synthase 4719519 6228071 MMAR_3799 Mycobacterium marinum M type I modular polyketide synthase YP_001852064.1 4713412 D 216594 CDS YP_001852065.1 183983774 6228072 4719544..4720494 1 NC_010612.1 function unknown role, perhaps as an acyltransferase or condensase in prodction of secondary metabolite from this locus. this locus is predicted to produce a Nrp:PKS fusion. the PKS product is an apolar hexaketide; beta-ketoacyl synthase-like protein 4720494 6228072 MMAR_3800 Mycobacterium marinum M beta-ketoacyl synthase-like protein YP_001852065.1 4719544 D 216594 CDS YP_001852066.1 183983775 6228073 complement(4720902..4721507) 1 NC_010612.1 MobA; links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide; involved in molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein A 4721507 mobA 6228073 mobA Mycobacterium marinum M molybdopterin-guanine dinucleotide biosynthesis protein A YP_001852066.1 4720902 R 216594 CDS YP_001852067.1 183983776 6228074 complement(4721509..4722600) 1 NC_010612.1 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; 2-oxoglutarate ferredoxin oxidoreductase subunit beta 4722600 porB 6228074 porB Mycobacterium marinum M 2-oxoglutarate ferredoxin oxidoreductase subunit beta YP_001852067.1 4721509 R 216594 CDS YP_001852068.1 183983777 6228075 complement(4722649..4724610) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; pyruvate:ferredoxin oxidoreductase, PorA, alpha subunit 4724610 porA 6228075 porA Mycobacterium marinum M pyruvate:ferredoxin oxidoreductase, PorA, alpha subunit YP_001852068.1 4722649 R 216594 CDS YP_001852069.1 183983778 6228076 complement(4724943..4726241) 1 NC_010612.1 thought to be involved in transport of undeterminated substrate (possibly sugar) across the membrane. responsible for the translocation of the substrate across the membrane; integral membrane transport protein 4726241 6228076 MMAR_3804 Mycobacterium marinum M integral membrane transport protein YP_001852069.1 4724943 R 216594 CDS YP_001852070.1 183983779 6228077 complement(4726251..4727531) 1 NC_010612.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 4727531 clpX 6228077 clpX Mycobacterium marinum M ATP-dependent protease ATP-binding subunit ClpX YP_001852070.1 4726251 R 216594 CDS YP_001852071.1 183983780 6228078 4728257..4729831 1 NC_010612.1 thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane; integral membrane transport protein 4729831 6228078 MMAR_3806 Mycobacterium marinum M integral membrane transport protein YP_001852071.1 4728257 D 216594 CDS YP_001852072.1 183983781 6228079 complement(4729888..4730523) 1 NC_010612.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 4730523 clpP2 6228079 clpP2 Mycobacterium marinum M ATP-dependent Clp protease proteolytic subunit YP_001852072.1 4729888 R 216594 CDS YP_001852073.1 183983782 6228080 complement(4730520..4731116) 1 NC_010612.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 4731116 clpP 6228080 clpP Mycobacterium marinum M ATP-dependent Clp protease proteolytic subunit YP_001852073.1 4730520 R 216594 CDS YP_001852074.1 183983783 6228081 complement(4731239..4732693) 1 NC_010612.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 4732693 tig 6228081 tig Mycobacterium marinum M trigger factor YP_001852074.1 4731239 R 216594 CDS YP_001852075.1 183983784 6228084 4733075..4734259 1 NC_010612.1 function unknown, lipolytic enzyme involved in cellular metabolism; esterase/lipase LipP 4734259 lipP 6228084 lipP Mycobacterium marinum M esterase/lipase LipP YP_001852075.1 4733075 D 216594 CDS YP_001852076.1 183983785 6228085 complement(4734343..4734702) 1 NC_010612.1 hypothetical protein 4734702 6228085 MMAR_3811 Mycobacterium marinum M hypothetical protein YP_001852076.1 4734343 R 216594 CDS YP_001852077.1 183983786 6228086 complement(4734830..4735636) 1 NC_010612.1 hydrolyses DNA (this enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents); formamidopyrimidine-DNA glycosylase 4735636 6228086 MMAR_3812 Mycobacterium marinum M formamidopyrimidine-DNA glycosylase YP_001852077.1 4734830 R 216594 CDS YP_001852078.1 183983787 6228087 complement(4735645..4736124) 1 NC_010612.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 4736124 rpiB 6228087 rpiB Mycobacterium marinum M ribose-5-phosphate isomerase B YP_001852078.1 4735645 R 216594 CDS YP_001852079.1 183983788 6228088 complement(4736210..4737580) 1 NC_010612.1 involved in the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the inner membrane. responsible for the translocation of the substrate across the membrane; C4-dicarboxylate-transport transmembrane protein DctA 4737580 dctA 6228088 dctA Mycobacterium marinum M C4-dicarboxylate-transport transmembrane protein DctA YP_001852079.1 4736210 R 216594 CDS YP_001852080.1 183983789 6228089 complement(4737712..4738335) 1 NC_010612.1 function unknown but contains a DSBA-like thioredoxin domain; hypothetical protein 4738335 6228089 MMAR_3815 Mycobacterium marinum M hypothetical protein YP_001852080.1 4737712 R 216594 CDS YP_001852081.1 183983790 6228090 complement(4738436..4740154) 1 NC_010612.1 PE-PGRS family protein 4740154 6228090 MMAR_3816 Mycobacterium marinum M PE-PGRS family protein YP_001852081.1 4738436 R 216594 CDS YP_001852082.1 183983791 6228091 4740430..4743009 1 NC_010612.1 aminopeptidase with broad substrate specificity to several peptides (could preferentially cleave leucine, arginine and lysine in peptide-bond-containing substrates); aminopeptidase N PepN 4743009 pepN 6228091 pepN Mycobacterium marinum M aminopeptidase N PepN YP_001852082.1 4740430 D 216594 CDS YP_001852083.1 183983792 6228092 complement(4743046..4743549) 1 NC_010612.1 hypothetical protein 4743549 6228092 MMAR_3818 Mycobacterium marinum M hypothetical protein YP_001852083.1 4743046 R 216594 CDS YP_001852084.1 183983793 6228093 complement(4743500..4743742) 1 NC_010612.1 hypothetical protein 4743742 6228093 MMAR_3819 Mycobacterium marinum M hypothetical protein YP_001852084.1 4743500 R 216594 CDS YP_001852085.1 183983794 6228094 complement(4743835..4744476) 1 NC_010612.1 function unknown but contains McrA, restriction endonuclease domain; hypothetical protein 4744476 6228094 MMAR_3820 Mycobacterium marinum M hypothetical protein YP_001852085.1 4743835 R 216594 CDS YP_001852086.1 183983795 6228095 4744630..4745016 1 NC_010612.1 oxygen carrier, involved in oxygen transport; globin (oxygen-binding protein) GlbO 4745016 glbO 6228095 glbO Mycobacterium marinum M globin (oxygen-binding protein) GlbO YP_001852086.1 4744630 D 216594 CDS YP_001852087.1 183983796 6228096 4745016..4746593 1 NC_010612.1 involved in sugar metabolism (hydrolysis of terminal, non-reducing 1,4-linked d-glucose residues with release of d-glucose); alpha-glucosidase AglA 4746593 aglA 6228096 aglA Mycobacterium marinum M alpha-glucosidase AglA YP_001852087.1 4745016 D 216594 CDS YP_001852088.1 183983797 6228097 4746806..4748362 1 NC_010612.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB 4748362 plcB_1 6228097 plcB_1 Mycobacterium marinum M membrane-associated phospholipase C2 PlcB YP_001852088.1 4746806 D 216594 CDS YP_001852089.1 183983798 6228098 complement(4748390..4750129) 1 NC_010612.1 involved in cholesterol metabolism [catalytic activity: cholesterol + O(2) = cholest-4-en-3-one + H(2)O(2)]; cholesterol oxidase ChoD 4750129 choD_1 6228098 choD_1 Mycobacterium marinum M cholesterol oxidase ChoD YP_001852089.1 4748390 R 216594 CDS YP_001852090.1 183983799 6228099 complement(4750213..4751748) 1 NC_010612.1 thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane; drug-transport integral membrane protein 4751748 6228099 MMAR_3825 Mycobacterium marinum M drug-transport integral membrane protein YP_001852090.1 4750213 R 216594 CDS YP_001852091.1 183983800 6228100 complement(4751745..4753934) 1 NC_010612.1 involved in biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (MoaD); hypothetical protein 4753934 moeY_1 6228100 moeY_1 Mycobacterium marinum M hypothetical protein YP_001852091.1 4751745 R 216594 CDS YP_001852092.1 183983801 6228101 complement(4754446..4755108) 1 NC_010612.1 hypothetical protein 4755108 6228101 MMAR_3827 Mycobacterium marinum M hypothetical protein YP_001852092.1 4754446 R 216594 CDS YP_001852093.1 183983802 6228102 complement(4755105..4755521) 1 NC_010612.1 function unknown but some identity with thioesterase domains; hypothetical protein 4755521 6228102 MMAR_3828 Mycobacterium marinum M hypothetical protein YP_001852093.1 4755105 R 216594 CDS YP_001852094.1 183983803 6228103 complement(4755518..4760356) 1 NC_010612.1 catabolic GlutDH involved in the utilization of glutamate and other amino acids of the glutamate family. generates 2-oxoglutarate from L-glutamate [catalytic activity: L-glutamate + H(2)O + NAD(+) = 2-oxoglutarate + NH(3) + NADH]; NAD-dependent glutamate dehydrogenase Gdh 4760356 gdh 6228103 gdh Mycobacterium marinum M NAD-dependent glutamate dehydrogenase Gdh YP_001852094.1 4755518 R 216594 CDS YP_001852095.1 183983804 6228104 complement(4760517..4762193) 1 NC_010612.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 4762193 6228104 MMAR_3830 Mycobacterium marinum M putative ABC transporter ATP-binding protein YP_001852095.1 4760517 R 216594 CDS YP_001852096.1 183983805 6228105 complement(4762261..4762779) 1 NC_010612.1 function unknown but may play a role in DNA replication, recombination, and repair; hypothetical protein 4762779 6228105 MMAR_3831 Mycobacterium marinum M hypothetical protein YP_001852096.1 4762261 R 216594 CDS YP_001852097.1 183983806 6228106 4763392..4764321 1 NC_010612.1 involved in lipid desaturation; membrane-bound C-5 sterol desaturase 4764321 erg3_2 6228106 erg3_2 Mycobacterium marinum M membrane-bound C-5 sterol desaturase YP_001852097.1 4763392 D 216594 CDS YP_001852098.1 183983807 6228107 complement(4764379..4766745) 1 NC_010612.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 4766745 plsB2 6228107 plsB2 Mycobacterium marinum M glycerol-3-phosphate acyltransferase YP_001852098.1 4764379 R 216594 CDS YP_001852099.1 183983808 6228108 complement(4766742..4768697) 1 NC_010612.1 N-terminus: could be generate serine and phosphate from phosphoserine; may catalyze the last step in the biosynthesis of serine from carbohydrates (the reaction mechanism could be proceed via the formation of a phosphoryl-enzyme intermediates) [catalytic activity 1: phosphoserine + H(2)O = serine + phosphate]. mid-section: involved in phospholipid biosynthesis (at the second step); converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position [catalytic activity 2: acyl-CoA + 1-acyl-SN- glycerol 3-phosphate = CoA + 1,2-diacyl-SN-glycerol 3- phosphate]. c-terminus: contains tola protein domain homology. may serve to anchor this protein in the cm; bifunctional transmembrane phospholipid biosynthesis enzyme PlsC 4768697 plsC 6228108 plsC Mycobacterium marinum M bifunctional transmembrane phospholipid biosynthesis enzyme PlsC YP_001852099.1 4766742 R 216594 CDS YP_001852100.1 183983809 6228109 complement(4768694..4770157) 1 NC_010612.1 function unknown but N-term contains a CoA- dependanant acyltransferase domain; hypothetical protein 4770157 6228109 MMAR_3835 Mycobacterium marinum M hypothetical protein YP_001852100.1 4768694 R 216594 CDS YP_001852101.1 183983810 6228110 complement(4770390..4771637) 1 NC_010612.1 function unknown, lipolytic enzyme involved in cellular metabolism; carboxylesterase LipQ 4771637 lipQ 6228110 lipQ Mycobacterium marinum M carboxylesterase LipQ YP_001852101.1 4770390 R 216594 CDS YP_001852102.1 183983811 6228112 4772150..4772857 1 NC_010612.1 hydrolyzes cutin; cutinase 4772857 6228112 MMAR_3837 Mycobacterium marinum M cutinase YP_001852102.1 4772150 D 216594 CDS YP_001852103.1 183983812 6228113 complement(4772989..4773300) 1 NC_010612.1 hypothetical protein 4773300 6228113 MMAR_5558 Mycobacterium marinum M hypothetical protein YP_001852103.1 4772989 R 216594 CDS YP_001852104.1 183983813 6228114 complement(4773503..4774978) 1 NC_010612.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation; cobyric acid synthase 4774978 cobQ1 6228114 cobQ1 Mycobacterium marinum M cobyric acid synthase YP_001852104.1 4773503 R 216594 CDS YP_001852105.1 183983814 6228115 4775745..4776089 1 NC_010612.1 hypothetical protein 4776089 6228115 MMAR_3839 Mycobacterium marinum M hypothetical protein YP_001852105.1 4775745 D 216594 CDS YP_001852106.1 183983815 6228116 4776401..4776763 1 NC_010612.1 hypothetical protein 4776763 6228116 MMAR_3840 Mycobacterium marinum M hypothetical protein YP_001852106.1 4776401 D 216594 CDS YP_001852107.1 183983816 6228117 complement(4776782..4777651) 1 NC_010612.1 involved in mycolic acids modification. catalyzes unusual S-adenosyl-methionine-dependent transformation of a cis-olefin mycolic acid into a secondary alcohol. catalyzes introduction of a hydroxyl group at the distal position on mycolic acid chains to produce the hydroxyl mycolate. mycolic acids represent a major constituent of the mycobacterial cell wall complex. methyl transfer results in formation of a secondary hydroxy group with an adjacent methyl branch; olefinic mycolic acid methyl transferase; methoxy mycolic acid synthase 5 MmaA5 4777651 mmaA5 6228117 mmaA5 Mycobacterium marinum M methoxy mycolic acid synthase 5 MmaA5 YP_001852107.1 4776782 R 216594 CDS YP_001852108.1 183983817 6228118 complement(4777970..4779139) 1 NC_010612.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; branched-chain alpha-keto acid dehydrogenase subunit E2 4779139 pdhC 6228118 pdhC Mycobacterium marinum M branched-chain alpha-keto acid dehydrogenase subunit E2 YP_001852108.1 4777970 R 216594 CDS YP_001852109.1 183983818 6228119 complement(4779136..4780182) 1 NC_010612.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component subunit PdhB 4780182 pdhB 6228119 pdhB Mycobacterium marinum M pyruvate dehydrogenase E1 component subunit PdhB YP_001852109.1 4779136 R 216594 CDS YP_001852110.1 183983819 6228120 complement(4780193..4781284) 1 NC_010612.1 involved in energy metabolism. the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA & CO(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) & lipoamide dehydrogenase (E3) [catalytic activity: acetyl-CoA + dihydrolipoamide = CoA + s- acetyldihydrolipoamide]; pyruvate dehydrogenase E1 component subunit PdhA 4781284 pdhA 6228120 pdhA Mycobacterium marinum M pyruvate dehydrogenase E1 component subunit PdhA YP_001852110.1 4780193 R 216594 CDS YP_001852111.1 183983820 6228121 complement(4781625..4782446) 1 NC_010612.1 interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate]; citrate (pro-3S)-lyase subunit beta 4782446 citE 6228121 citE Mycobacterium marinum M citrate (pro-3S)-lyase subunit beta YP_001852111.1 4781625 R 216594 CDS YP_001852112.1 183983821 6228122 complement(4782443..4782949) 1 NC_010612.1 function unknown but contains a central MaoC, acyl dehydratase domain; hypothetical protein 4782949 6228122 MMAR_3846 Mycobacterium marinum M hypothetical protein YP_001852112.1 4782443 R 216594 CDS YP_001852113.1 183983822 6228123 complement(4782946..4784112) 1 NC_010612.1 function unknown, but seems involved in metabolism of small branched-chain fatty acids and macrolide antibiotic production. catalyses the alpha, beta- dehydrogenetion of acyl-CoA esters and transfer electrons to ETF, the electron transfer protein; acyl-CoA dehydrogenase FadE19 4784112 fadE19 6228123 fadE19 Mycobacterium marinum M acyl-CoA dehydrogenase FadE19 YP_001852113.1 4782946 R 216594 CDS YP_001852114.1 183983823 6228124 complement(4784119..4786128) 1 NC_010612.1 this protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. involved in the first step of long-chain fatty acid synthesis [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + phosphate + carboxybiotin-carboxyl-carrier protein]; acetyl-/propionyl-coenzyme A carboxylase alpha chain AccA1 4786128 accA1 6228124 accA1 Mycobacterium marinum M acetyl-/propionyl-coenzyme A carboxylase alpha chain AccA1 YP_001852114.1 4784119 R 216594 CDS YP_001852115.1 183983824 6228125 complement(4786132..4787712) 1 NC_010612.1 involved in fatty acid metabolism; acetyl-/propionyl-CoA carboxylase subunit beta 4787712 accD1 6228125 accD1 Mycobacterium marinum M acetyl-/propionyl-CoA carboxylase subunit beta YP_001852115.1 4786132 R 216594 CDS YP_001852116.1 183983825 6228126 complement(4787709..4788356) 1 NC_010612.1 involved in various degradation and synthesis [catalytic activity: succinyl-CoA + a 3-OXO acid = succinate + a 3-OXO-acyl-CoA]; succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta ScoB 4788356 scoB 6228126 scoB Mycobacterium marinum M succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta ScoB YP_001852116.1 4787709 R 216594 CDS YP_001852117.1 183983826 6228127 complement(4788459..4789205) 1 NC_010612.1 involved in fatty acid degradation/synthesis [catalytic activity: succinyl-CoA + a 3-OXO acid = succinate + a 3-OXO-acyl-CoA]; succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha ScoA 4789205 scoA 6228127 scoA Mycobacterium marinum M succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha ScoA YP_001852117.1 4788459 R 216594 CDS YP_001852118.1 183983827 6228128 complement(4789326..4790969) 1 NC_010612.1 function unknown, but involved in lipid degradation; AMP-binding protein 4790969 fadD35 6228128 fadD35 Mycobacterium marinum M AMP-binding protein YP_001852118.1 4789326 R 216594 CDS YP_001852119.1 183983828 6228129 4791074..4791709 1 NC_010612.1 involved in transcriptional mechanism; putative regulatory protein 4791709 6228129 MMAR_3853 Mycobacterium marinum M putative regulatory protein YP_001852119.1 4791074 D 216594 CDS YP_001852120.1 183983829 6228130 4791940..4792731 1 NC_010612.1 proline rich membrane protein 4792731 6228130 MMAR_3854 Mycobacterium marinum M proline rich membrane protein YP_001852120.1 4791940 D 216594 CDS YP_001852121.1 183983830 6228131 complement(4792728..4794056) 1 NC_010612.1 integral membrane leucine and alanine rich protein 4794056 6228131 MMAR_3855 Mycobacterium marinum M integral membrane leucine and alanine rich protein YP_001852121.1 4792728 R 216594 CDS YP_001852122.1 183983831 6228132 4794152..4794958 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 4794958 6228132 MMAR_3856 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001852122.1 4794152 D 216594 CDS YP_001852123.1 183983832 6228133 4795064..4796035 1 NC_010612.1 transposition of ISMyma04; transposase for ISMyma04 4796035 6228133 MMAR_3857 Mycobacterium marinum M transposase for ISMyma04 YP_001852123.1 4795064 D 216594 CDS YP_001852124.1 183983833 6228134 complement(4796053..4797660) 1 NC_010612.1 function unknown but contains ATPase domain; hypothetical protein 4797660 6228134 MMAR_3858 Mycobacterium marinum M hypothetical protein YP_001852124.1 4796053 R 216594 CDS YP_001852125.1 183983834 6228135 4797775..4798422 1 NC_010612.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4798422 orn 6228135 orn Mycobacterium marinum M oligoribonuclease YP_001852125.1 4797775 D 216594 CDS YP_001852126.1 183983835 6228137 complement(4798608..4799309) 1 NC_010612.1 hypothetical protein 4799309 6228137 MMAR_3860 Mycobacterium marinum M hypothetical protein YP_001852126.1 4798608 R 216594 CDS YP_001852127.1 183983836 6228138 complement(4799442..4800062) 1 NC_010612.1 involved in transcriptional mechanism; putative regulatory protein 4800062 6228138 MMAR_3861 Mycobacterium marinum M putative regulatory protein YP_001852127.1 4799442 R 216594 CDS YP_001852128.1 183983837 6228139 4800360..4801229 1 NC_010612.1 function unknown, YrbE family protein that is similar to Ttg2B-like ABC-type transport system involved in resistance to organic solvents, permease component; YrbE family protein, YrbE5A 4801229 yrbE5A 6228139 yrbE5A Mycobacterium marinum M YrbE family protein, YrbE5A YP_001852128.1 4800360 D 216594 CDS YP_001852129.1 183983838 6228140 4801231..4802094 1 NC_010612.1 function unknown but similar to Ttg2B-like ABC-type transport system involved in resistance to organic solvents, permease component; integral ABC-type transport protein 4802094 6228140 MMAR_3863 Mycobacterium marinum M integral ABC-type transport protein YP_001852129.1 4801231 D 216594 CDS YP_001852130.1 183983839 6228141 4802118..4803650 1 NC_010612.1 this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria; Mce protein, Mce5A 4803650 mce5A 6228141 mce5A Mycobacterium marinum M Mce protein, Mce5A YP_001852130.1 4802118 D 216594 CDS YP_001852131.1 183983840 6228142 4803647..4804702 1 NC_010612.1 this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria; Mce family protein, Mce5B 4804702 mce5B 6228142 mce5B Mycobacterium marinum M Mce family protein, Mce5B YP_001852131.1 4803647 D 216594 CDS YP_001852132.1 183983841 6228143 4804695..4805750 1 NC_010612.1 this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria; Mce family protein, Mce5C 4805750 mce5C 6228143 mce5C Mycobacterium marinum M Mce family protein, Mce5C YP_001852132.1 4804695 D 216594 CDS YP_001852133.1 183983842 6228144 4805747..4806862 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce5D 4806862 mce5D 6228144 mce5D Mycobacterium marinum M MCE-family protein Mce5D YP_001852133.1 4805747 D 216594 CDS YP_001852134.1 183983843 6228145 4806862..4808067 1 NC_010612.1 this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria; Mce family protein, Mce5E 4808067 mce5E 6228145 mce5E Mycobacterium marinum M Mce family protein, Mce5E YP_001852134.1 4806862 D 216594 CDS YP_001852135.1 183983844 6228146 4808064..4809314 1 NC_010612.1 this family of proteins contains the Mce (mycobacterial cell entry) proteins from mycobacterium tuberculosis. the archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. this family contains proteins of unknown function from other bacteria; Mce family protein Mce5F 4809314 mce5F 6228146 mce5F Mycobacterium marinum M Mce family protein Mce5F YP_001852135.1 4808064 D 216594 CDS YP_001852136.1 183983845 6228147 4809342..4810055 1 NC_010612.1 hypothetical protein 4810055 6228147 MMAR_3870 Mycobacterium marinum M hypothetical protein YP_001852136.1 4809342 D 216594 CDS YP_001852137.1 183983846 6228148 4810074..4810853 1 NC_010612.1 hypothetical protein 4810853 6228148 MMAR_3871 Mycobacterium marinum M hypothetical protein YP_001852137.1 4810074 D 216594 CDS YP_001852138.1 183983847 6228149 complement(4810855..4812054) 1 NC_010612.1 lipoprotein LppS 4812054 lppS 6228149 lppS Mycobacterium marinum M lipoprotein LppS YP_001852138.1 4810855 R 216594 CDS YP_001852139.1 183983848 6228150 4812058..4812195 1 NC_010612.1 hypothetical protein 4812195 6228150 MMAR_5557 Mycobacterium marinum M hypothetical protein YP_001852139.1 4812058 D 216594 CDS YP_001852140.1 183983849 6228152 4812550..4812897 1 NC_010612.1 hypothetical protein 4812897 6228152 MMAR_3873 Mycobacterium marinum M hypothetical protein YP_001852140.1 4812550 D 216594 CDS YP_001852141.1 183983850 6228153 4812894..4813187 1 NC_010612.1 hypothetical protein 4813187 6228153 MMAR_3874 Mycobacterium marinum M hypothetical protein YP_001852141.1 4812894 D 216594 CDS YP_001852142.1 183983851 6228154 4813205..4814056 1 NC_010612.1 member of the mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins; PE-PGRS family protein 4814056 6228154 MMAR_3875 Mycobacterium marinum M PE-PGRS family protein YP_001852142.1 4813205 D 216594 CDS YP_001852143.1 183983852 6228155 complement(4814152..4814427) 1 NC_010612.1 hypothetical protein 4814427 6228155 MMAR_3876 Mycobacterium marinum M hypothetical protein YP_001852143.1 4814152 R 216594 CDS YP_001852144.1 183983853 6228156 complement(4814444..4814854) 1 NC_010612.1 hypothetical protein 4814854 6228156 MMAR_3877 Mycobacterium marinum M hypothetical protein YP_001852144.1 4814444 R 216594 CDS YP_001852145.1 183983854 6228157 complement(4815193..4816152) 1 NC_010612.1 hypothetical protein 4816152 6228157 MMAR_3878 Mycobacterium marinum M hypothetical protein YP_001852145.1 4815193 R 216594 CDS YP_001852146.1 183983855 6228158 complement(4816364..4817587) 1 NC_010612.1 hypothetical protein 4817587 6228158 MMAR_3879 Mycobacterium marinum M hypothetical protein YP_001852146.1 4816364 R 216594 CDS YP_001852147.1 183983856 6228159 complement(4817587..4817814) 1 NC_010612.1 hypothetical protein 4817814 6228159 MMAR_3880 Mycobacterium marinum M hypothetical protein YP_001852147.1 4817587 R 216594 CDS YP_001852148.1 183983857 6228160 complement(4818132..4818419) 1 NC_010612.1 hypothetical protein 4818419 6228160 MMAR_3881 Mycobacterium marinum M hypothetical protein YP_001852148.1 4818132 R 216594 CDS YP_001852149.1 183983858 6228161 complement(4818419..4822000) 1 NC_010612.1 bacteriophage membrane protein 4822000 6228161 MMAR_3882 Mycobacterium marinum M bacteriophage membrane protein YP_001852149.1 4818419 R 216594 CDS YP_001852150.1 183983859 6228162 complement(4821997..4823682) 1 NC_010612.1 bacteriophage membrane protein 4823682 6228162 MMAR_3883 Mycobacterium marinum M bacteriophage membrane protein YP_001852150.1 4821997 R 216594 CDS YP_001852151.1 183983860 6228163 complement(4823794..4824150) 1 NC_010612.1 hypothetical protein 4824150 6228163 MMAR_3884 Mycobacterium marinum M hypothetical protein YP_001852151.1 4823794 R 216594 CDS YP_001852152.1 183983861 6228164 complement(4824230..4825093) 1 NC_010612.1 hypothetical protein 4825093 6228164 MMAR_3885 Mycobacterium marinum M hypothetical protein YP_001852152.1 4824230 R 216594 CDS YP_001852153.1 183983862 6228165 complement(4825093..4830081) 1 NC_010612.1 bacteriophage-like membrane protein 4830081 6228165 MMAR_3886 Mycobacterium marinum M bacteriophage-like membrane protein YP_001852153.1 4825093 R 216594 CDS YP_001852154.1 183983863 6228166 complement(4830368..4831090) 1 NC_010612.1 hypothetical protein 4831090 6228166 MMAR_3887 Mycobacterium marinum M hypothetical protein YP_001852154.1 4830368 R 216594 CDS YP_001852155.1 183983864 6228167 complement(4831130..4831993) 1 NC_010612.1 function unknown; contains a fibronectin type 3 domain; hypothetical protein 4831993 6228167 MMAR_3888 Mycobacterium marinum M hypothetical protein YP_001852155.1 4831130 R 216594 CDS YP_001852156.1 183983865 6228168 complement(4831994..4832227) 1 NC_010612.1 hypothetical protein 4832227 6228168 MMAR_3889 Mycobacterium marinum M hypothetical protein YP_001852156.1 4831994 R 216594 CDS YP_001852157.1 183983866 6228169 complement(4832247..4832675) 1 NC_010612.1 hypothetical protein 4832675 6228169 MMAR_3890 Mycobacterium marinum M hypothetical protein YP_001852157.1 4832247 R 216594 CDS YP_001852158.1 183983867 6228170 complement(4832707..4833141) 1 NC_010612.1 phage-like protein 4833141 6228170 MMAR_3891 Mycobacterium marinum M phage-like protein YP_001852158.1 4832707 R 216594 CDS YP_001852159.1 183983868 6228171 complement(4833147..4833554) 1 NC_010612.1 phage-like protein 4833554 6228171 MMAR_3892 Mycobacterium marinum M phage-like protein YP_001852159.1 4833147 R 216594 CDS YP_001852160.1 183983869 6228172 complement(4833547..4833954) 1 NC_010612.1 hypothetical protein 4833954 6228172 MMAR_3893 Mycobacterium marinum M hypothetical protein YP_001852160.1 4833547 R 216594 CDS YP_001852161.1 183983870 6228173 complement(4833961..4834392) 1 NC_010612.1 hypothetical protein 4834392 6228173 MMAR_3894 Mycobacterium marinum M hypothetical protein YP_001852161.1 4833961 R 216594 CDS YP_001852162.1 183983871 6228174 complement(4834389..4834706) 1 NC_010612.1 phage-like protein 4834706 6228174 MMAR_3895 Mycobacterium marinum M phage-like protein YP_001852162.1 4834389 R 216594 CDS YP_001852163.1 183983872 6228175 complement(4834730..4835791) 1 NC_010612.1 may be involved in phage capsid construction; phage structural protein 4835791 6228175 MMAR_3896 Mycobacterium marinum M phage structural protein YP_001852163.1 4834730 R 216594 CDS YP_001852164.1 183983873 6228176 complement(4835806..4836516) 1 NC_010612.1 phage-like protein 4836516 6228176 MMAR_3897 Mycobacterium marinum M phage-like protein YP_001852164.1 4835806 R 216594 CDS YP_001852165.1 183983874 6228177 complement(4836534..4837244) 1 NC_010612.1 hypothetical protein 4837244 6228177 MMAR_3898 Mycobacterium marinum M hypothetical protein YP_001852165.1 4836534 R 216594 CDS YP_001852166.1 183983875 6228178 complement(4837346..4838563) 1 NC_010612.1 hypothetical protein 4838563 6228178 MMAR_3899 Mycobacterium marinum M hypothetical protein YP_001852166.1 4837346 R 216594 CDS YP_001852167.1 183983876 6228179 complement(4838547..4840118) 1 NC_010612.1 hypothetical protein 4840118 6228179 MMAR_3900 Mycobacterium marinum M hypothetical protein YP_001852167.1 4838547 R 216594 CDS YP_001852168.1 183983877 6228180 complement(4840132..4841805) 1 NC_010612.1 function unknown - possible role in phage replication; phage terminase-like large subunit protein 4841805 6228180 MMAR_3901 Mycobacterium marinum M phage terminase-like large subunit protein YP_001852168.1 4840132 R 216594 CDS YP_001852169.1 183983878 6228181 complement(4841812..4842288) 1 NC_010612.1 hypothetical protein 4842288 6228181 MMAR_3902 Mycobacterium marinum M hypothetical protein YP_001852169.1 4841812 R 216594 CDS YP_001852170.1 183983879 6228182 complement(4842522..4843199) 1 NC_010612.1 hypothetical protein 4843199 6228182 MMAR_3903 Mycobacterium marinum M hypothetical protein YP_001852170.1 4842522 R 216594 CDS YP_001852171.1 183983880 6228183 complement(4843231..4843587) 1 NC_010612.1 hypothetical protein 4843587 6228183 MMAR_3904 Mycobacterium marinum M hypothetical protein YP_001852171.1 4843231 R 216594 CDS YP_001852172.1 183983881 6228184 complement(4843587..4843814) 1 NC_010612.1 hypothetical protein 4843814 6228184 MMAR_3905 Mycobacterium marinum M hypothetical protein YP_001852172.1 4843587 R 216594 CDS YP_001852173.1 183983882 6228185 complement(4843840..4844403) 1 NC_010612.1 hypothetical protein 4844403 6228185 MMAR_3906 Mycobacterium marinum M hypothetical protein YP_001852173.1 4843840 R 216594 CDS YP_001852174.1 183983883 6228186 4844802..4845194 1 NC_010612.1 hypothetical protein 4845194 6228186 MMAR_3908 Mycobacterium marinum M hypothetical protein YP_001852174.1 4844802 D 216594 CDS YP_001852175.1 183983884 6228187 complement(4845196..4845762) 1 NC_010612.1 hypothetical protein 4845762 6228187 MMAR_3909 Mycobacterium marinum M hypothetical protein YP_001852175.1 4845196 R 216594 CDS YP_001852176.1 183983885 6228188 complement(4845782..4846069) 1 NC_010612.1 hypothetical protein 4846069 6228188 MMAR_3910 Mycobacterium marinum M hypothetical protein YP_001852176.1 4845782 R 216594 CDS YP_001852177.1 183983886 6228189 complement(4846099..4846251) 1 NC_010612.1 hypothetical protein 4846251 6228189 MMAR_3911 Mycobacterium marinum M hypothetical protein YP_001852177.1 4846099 R 216594 CDS YP_001852178.1 183983887 6228190 complement(4847507..4848031) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 4848031 6228190 MMAR_3912 Mycobacterium marinum M transcriptional regulatory protein YP_001852178.1 4847507 R 216594 CDS YP_001852179.1 183983888 6228191 complement(4848674..4849135) 1 NC_010612.1 hypothetical protein 4849135 6228191 MMAR_3913 Mycobacterium marinum M hypothetical protein YP_001852179.1 4848674 R 216594 CDS YP_001852180.1 183983889 6228192 complement(4849132..4849374) 1 NC_010612.1 hypothetical protein 4849374 6228192 MMAR_3914 Mycobacterium marinum M hypothetical protein YP_001852180.1 4849132 R 216594 CDS YP_001852181.1 183983890 6228193 complement(4849371..4849610) 1 NC_010612.1 hypothetical protein 4849610 6228193 MMAR_3915 Mycobacterium marinum M hypothetical protein YP_001852181.1 4849371 R 216594 CDS YP_001852182.1 183983891 6228194 complement(4849603..4850187) 1 NC_010612.1 hypothetical protein 4850187 6228194 MMAR_3916 Mycobacterium marinum M hypothetical protein YP_001852182.1 4849603 R 216594 CDS YP_001852183.1 183983892 6228195 complement(4850180..4851325) 1 NC_010612.1 hypothetical protein 4851325 6228195 MMAR_3917 Mycobacterium marinum M hypothetical protein YP_001852183.1 4850180 R 216594 CDS YP_001852184.1 183983893 6228196 complement(4851643..4851963) 1 NC_010612.1 hypothetical protein 4851963 6228196 MMAR_3919 Mycobacterium marinum M hypothetical protein YP_001852184.1 4851643 R 216594 CDS YP_001852185.1 183983894 6228197 complement(4852346..4853221) 1 NC_010612.1 function unknown; possible role in phage DNA restriction modification system; phage DNA methylase 4853221 6228197 MMAR_3921 Mycobacterium marinum M phage DNA methylase YP_001852185.1 4852346 R 216594 CDS YP_001852186.1 183983895 6228198 complement(4853403..4854230) 1 NC_010612.1 function unknown; homology suggests possible regulatory protein; hypothetical protein 4854230 6228198 MMAR_3923 Mycobacterium marinum M hypothetical protein YP_001852186.1 4853403 R 216594 CDS YP_001852187.1 183983896 6228199 complement(4854227..4854529) 1 NC_010612.1 hypothetical protein 4854529 6228199 MMAR_3924 Mycobacterium marinum M hypothetical protein YP_001852187.1 4854227 R 216594 CDS YP_001852188.1 183983897 6228200 complement(4854529..4854801) 1 NC_010612.1 hypothetical protein 4854801 6228200 MMAR_3925 Mycobacterium marinum M hypothetical protein YP_001852188.1 4854529 R 216594 CDS YP_001852189.1 183983898 6228201 complement(4854804..4855946) 1 NC_010612.1 probably involved in phage genome replication. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. this DNA polymerase also exhibits 3' to 5' exonuclease activity. the beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA [catalytic activity: N deoxynucleoside triphosphate = N diphosphate + {DNA}n]; DNA polymerase III (beta chain) DnaN 4855946 dnaN_1 6228201 dnaN_1 Mycobacterium marinum M DNA polymerase III (beta chain) DnaN YP_001852189.1 4854804 R 216594 CDS YP_001852190.1 183983899 6228202 complement(4856155..4857282) 1 NC_010612.1 Possible role in phage replication. Domain identity with rect family. The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, Erf and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways; RecT-family phage protein 4857282 6228202 MMAR_3927 Mycobacterium marinum M RecT-family phage protein YP_001852190.1 4856155 R 216594 CDS YP_001852191.1 183983900 6228203 complement(4857279..4857779) 1 NC_010612.1 hypothetical protein 4857779 6228203 MMAR_3928 Mycobacterium marinum M hypothetical protein YP_001852191.1 4857279 R 216594 CDS YP_001852192.1 183983901 6228204 complement(4857776..4858855) 1 NC_010612.1 hypothetical protein 4858855 6228204 MMAR_3929 Mycobacterium marinum M hypothetical protein YP_001852192.1 4857776 R 216594 CDS YP_001852193.1 183983902 6228205 complement(4858852..4859082) 1 NC_010612.1 putative regulatory protein 4859082 6228205 MMAR_3930 Mycobacterium marinum M putative regulatory protein YP_001852193.1 4858852 R 216594 CDS YP_001852194.1 183983903 6228206 complement(4859240..4859638) 1 NC_010612.1 hypothetical protein 4859638 6228206 MMAR_3931 Mycobacterium marinum M hypothetical protein YP_001852194.1 4859240 R 216594 CDS YP_001852195.1 183983904 6228207 complement(4859635..4859967) 1 NC_010612.1 hypothetical protein 4859967 6228207 MMAR_3932 Mycobacterium marinum M hypothetical protein YP_001852195.1 4859635 R 216594 CDS YP_001852196.1 183983905 6228208 complement(4859967..4860353) 1 NC_010612.1 hypothetical protein 4860353 6228208 MMAR_3933 Mycobacterium marinum M hypothetical protein YP_001852196.1 4859967 R 216594 CDS YP_001852197.1 183983906 6228209 complement(4860350..4860610) 1 NC_010612.1 hypothetical protein 4860610 6228209 MMAR_3934 Mycobacterium marinum M hypothetical protein YP_001852197.1 4860350 R 216594 CDS YP_001852198.1 183983907 6228210 complement(4860673..4861086) 1 NC_010612.1 hypothetical protein 4861086 6228210 MMAR_3935 Mycobacterium marinum M hypothetical protein YP_001852198.1 4860673 R 216594 CDS YP_001852199.1 183983908 6228211 complement(4861083..4861307) 1 NC_010612.1 hypothetical protein 4861307 6228211 MMAR_3936 Mycobacterium marinum M hypothetical protein YP_001852199.1 4861083 R 216594 CDS YP_001852200.1 183983909 6228212 complement(4861304..4861588) 1 NC_010612.1 hypothetical protein 4861588 6228212 MMAR_3937 Mycobacterium marinum M hypothetical protein YP_001852200.1 4861304 R 216594 CDS YP_001852201.1 183983910 6228213 complement(4861585..4861776) 1 NC_010612.1 hypothetical protein 4861776 6228213 MMAR_3938 Mycobacterium marinum M hypothetical protein YP_001852201.1 4861585 R 216594 CDS YP_001852202.1 183983911 6228214 complement(4861773..4862048) 1 NC_010612.1 hypothetical protein 4862048 6228214 MMAR_3939 Mycobacterium marinum M hypothetical protein YP_001852202.1 4861773 R 216594 CDS YP_001852203.1 183983912 6228215 complement(4862045..4862623) 1 NC_010612.1 hypothetical protein 4862623 6228215 MMAR_3940 Mycobacterium marinum M hypothetical protein YP_001852203.1 4862045 R 216594 CDS YP_001852204.1 183983913 6228216 complement(4862620..4862955) 1 NC_010612.1 hypothetical protein 4862955 6228216 MMAR_3941 Mycobacterium marinum M hypothetical protein YP_001852204.1 4862620 R 216594 CDS YP_001852205.1 183983914 6228217 complement(4862952..4863188) 1 NC_010612.1 hypothetical protein 4863188 6228217 MMAR_3942 Mycobacterium marinum M hypothetical protein YP_001852205.1 4862952 R 216594 CDS YP_001852206.1 183983915 6228218 complement(4863185..4864207) 1 NC_010612.1 function unknown; putative role in regulation of transcription; phage antirepressor protein 4864207 6228218 MMAR_3943 Mycobacterium marinum M phage antirepressor protein YP_001852206.1 4863185 R 216594 CDS YP_001852207.1 183983916 6228219 complement(4864204..4864434) 1 NC_010612.1 hypothetical protein 4864434 6228219 MMAR_3944 Mycobacterium marinum M hypothetical protein YP_001852207.1 4864204 R 216594 CDS YP_001852208.1 183983917 6228220 complement(4864431..4864736) 1 NC_010612.1 hypothetical protein 4864736 6228220 MMAR_3945 Mycobacterium marinum M hypothetical protein YP_001852208.1 4864431 R 216594 CDS YP_001852209.1 183983918 6228221 4864904..4865470 1 NC_010612.1 hypothetical protein 4865470 6228221 MMAR_3946 Mycobacterium marinum M hypothetical protein YP_001852209.1 4864904 D 216594 CDS YP_001852210.1 183983919 6228222 4865692..4866378 1 NC_010612.1 contains a DNA binding domain. possibly involved in transcriptional mechanism; transcriptional regulatory protein 4866378 6228222 MMAR_3947 Mycobacterium marinum M transcriptional regulatory protein YP_001852210.1 4865692 D 216594 CDS YP_001852211.1 183983920 6228223 complement(4866349..4867146) 1 NC_010612.1 hydrolase 4867146 6228223 MMAR_3948 Mycobacterium marinum M hydrolase YP_001852211.1 4866349 R 216594 CDS YP_001852212.1 183983921 6228224 4867181..4867864 1 NC_010612.1 phage membrane protein 4867864 6228224 MMAR_3949 Mycobacterium marinum M phage membrane protein YP_001852212.1 4867181 D 216594 CDS YP_001852213.1 183983922 6228225 complement(4867853..4869109) 1 NC_010612.1 integration of phage genome into host chromosome; phage-related integrase 4869109 6228225 MMAR_3950 Mycobacterium marinum M phage-related integrase YP_001852213.1 4867853 R 216594 CDS YP_001852214.1 183983923 6228226 complement(4869106..4869477) 1 NC_010612.1 hypothetical protein 4869477 6228226 MMAR_3951 Mycobacterium marinum M hypothetical protein YP_001852214.1 4869106 R 216594 CDS YP_001852215.1 183983924 6228227 complement(4869671..4870252) 1 NC_010612.1 hypothetical protein 4870252 6228227 MMAR_3952 Mycobacterium marinum M hypothetical protein YP_001852215.1 4869671 R 216594 CDS YP_001852216.1 183983925 6228228 4870328..4871212 1 NC_010612.1 function unknown but domain identity suggests PlsC, phosphate acyltransferase. these enzymes function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2- acylglycerolphosphoethanolamine acyltransferase activities; hypothetical protein 4871212 6228228 MMAR_3953 Mycobacterium marinum M hypothetical protein YP_001852216.1 4870328 D 216594 CDS YP_001852217.1 183983926 6228229 4871405..4873144 1 NC_010612.1 hypothetical protein 4873144 6228229 MMAR_3954 Mycobacterium marinum M hypothetical protein YP_001852217.1 4871405 D 216594 CDS YP_001852218.1 183983927 6228230 complement(4873256..4873483) 1 NC_010612.1 hypothetical protein 4873483 6228230 MMAR_3955 Mycobacterium marinum M hypothetical protein YP_001852218.1 4873256 R 216594 CDS YP_001852219.1 183983928 6228231 4873591..4874064 1 NC_010612.1 putative antioxidant protein; bacterioferritin comigratory protein Bcp 4874064 bcp 6228231 bcp Mycobacterium marinum M bacterioferritin comigratory protein Bcp YP_001852219.1 4873591 D 216594 CDS YP_001852220.1 183983929 6228232 complement(4874065..4875390) 1 NC_010612.1 deacetylates acetylornithine and hydrolyses N- acetylmethionine; hypothetical protein 4875390 argE 6228232 argE Mycobacterium marinum M hypothetical protein YP_001852220.1 4874065 R 216594 CDS YP_001852221.1 183983930 6228233 4875433..4876575 1 NC_010612.1 involved in unknown signal transduction mechanism; two-component sensor kinase 4876575 6228233 MMAR_3958 Mycobacterium marinum M two-component sensor kinase YP_001852221.1 4875433 D 216594 CDS YP_001852222.1 183983931 6228234 4876572..4877228 1 NC_010612.1 regulator part of the two-component regulatory system; two-component transcriptional regulatory protein 4877228 6228234 MMAR_3959 Mycobacterium marinum M two-component transcriptional regulatory protein YP_001852222.1 4876572 D 216594 CDS YP_001852223.1 183983932 6228235 4877290..4879155 1 NC_010612.1 hypothetical protein 4879155 6228235 MMAR_3960 Mycobacterium marinum M hypothetical protein YP_001852223.1 4877290 D 216594 CDS YP_001852224.1 183983933 6228236 complement(4879229..4879621) 1 NC_010612.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 4879621 acpS 6228236 acpS Mycobacterium marinum M 4'-phosphopantetheinyl transferase YP_001852224.1 4879229 R 216594 CDS YP_001852225.1 183983934 6228237 complement(4879650..4888862) 1 NC_010612.1 involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH; fatty acid synthase Fas 4888862 fas 6228237 fas Mycobacterium marinum M fatty acid synthase Fas YP_001852225.1 4879650 R 216594 CDS YP_001852226.1 183983935 6228238 complement(4889374..4890096) 1 NC_010612.1 hypothetical protein 4890096 6228238 MMAR_3963 Mycobacterium marinum M hypothetical protein YP_001852226.1 4889374 R 216594 CDS YP_001852227.1 183983936 6228239 4890338..4891480 1 NC_010612.1 may act to bind either a ubiquinol or plastoquinol anion, transferring an electron to the 2Fe-2S cluster, then releasing the electron to a cytochrome C or cytochrome F haem iron; ring-hydroxylating dioxygenase, large terminal subunit 4891480 6228239 MMAR_3964 Mycobacterium marinum M ring-hydroxylating dioxygenase, large terminal subunit YP_001852227.1 4890338 D 216594 CDS YP_001852228.1 183983937 6228240 4891606..4893096 1 NC_010612.1 thought to oxidize a wide variety of aliphatic and aromatic aldehydes; NAD-dependent aldehyde dehydrogenase 4893096 6228240 MMAR_3965 Mycobacterium marinum M NAD-dependent aldehyde dehydrogenase YP_001852228.1 4891606 D 216594 CDS YP_001852229.1 183983938 6228241 complement(4893068..4893514) 1 NC_010612.1 function unknown role in lipid metabolism; contains a thioesterase/thiol ester dehydratase-isomerase superfamily domain; acyl dehydratase MaoC 4893514 maoC 6228241 maoC Mycobacterium marinum M acyl dehydratase MaoC YP_001852229.1 4893068 R 216594 CDS YP_001852230.1 183983939 6228242 complement(4893511..4894047) 1 NC_010612.1 function unknown but like D/S ORF it contains a thioesterase/thiol ester dehydrase-isomerase superfmaily domain; hypothetical protein 4894047 6228242 MMAR_3967 Mycobacterium marinum M hypothetical protein YP_001852230.1 4893511 R 216594 CDS YP_001852231.1 183983940 6228243 complement(4894053..4894712) 1 NC_010612.1 hypothetical protein 4894712 6228243 MMAR_3968 Mycobacterium marinum M hypothetical protein YP_001852231.1 4894053 R 216594 CDS YP_001852232.1 183983941 6228244 4895206..4896417 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 269A1 Cyp269A1 4896417 cyp269A1 6228244 cyp269A1 Mycobacterium marinum M cytochrome P450 269A1 Cyp269A1 YP_001852232.1 4895206 D 216594 CDS YP_001852233.1 183983942 6228245 4896448..4898133 1 NC_010612.1 function unknown, possibly involved in transport of drug across the membrane. contains AraJ, arabinose efflux permease domain identity; hypothetical protein 4898133 6228245 MMAR_3970 Mycobacterium marinum M hypothetical protein YP_001852233.1 4896448 D 216594 CDS YP_001852234.1 183983943 6228246 complement(4898412..4899539) 1 NC_010612.1 function unknown, probably involved in cellular metabolism. contains domain identity to phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases; oxidoreductase 4899539 6228246 MMAR_3971 Mycobacterium marinum M oxidoreductase YP_001852234.1 4898412 R 216594 CDS YP_001852235.1 183983944 6228247 complement(4899821..4902985) 1 NC_010612.1 contains an NRP-like adenylation domain; non-ribosomal peptide synthetase 4902985 6228247 MMAR_3972 Mycobacterium marinum M non-ribosomal peptide synthetase YP_001852235.1 4899821 R 216594 CDS YP_001852236.1 183983945 6228248 complement(4904038..4904229) 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin FdxD 4904229 fdxD_1 6228248 fdxD_1 Mycobacterium marinum M ferredoxin FdxD YP_001852236.1 4904038 R 216594 CDS YP_001852237.1 183983946 6228249 complement(4904247..4906652) 1 NC_010612.1 function unknown but contains acyl-CoA transferases/carnitine dehydratase domain homology; acyl-CoA transferase 4906652 6228249 MMAR_3974 Mycobacterium marinum M acyl-CoA transferase YP_001852237.1 4904247 R 216594 CDS YP_001852238.1 183983947 6228250 4906750..4907571 1 NC_010612.1 involved in transcriptional mechanism; FadR family transcriptional regulator 4907571 6228250 MMAR_3975 Mycobacterium marinum M FadR family transcriptional regulator YP_001852238.1 4906750 D 216594 CDS YP_001852239.1 183983948 6228251 4908243..4909571 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 138A4 Cyp138A4 4909571 cyp138A4 6228251 cyp138A4 Mycobacterium marinum M cytochrome P450 138A4 Cyp138A4 YP_001852239.1 4908243 D 216594 CDS YP_001852240.1 183983949 6228252 4909661..4911160 1 NC_010612.1 thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane; drug-transport integral membrane protein 4911160 6228252 MMAR_3977 Mycobacterium marinum M drug-transport integral membrane protein YP_001852240.1 4909661 D 216594 CDS YP_001852241.1 183983950 6228253 complement(4911283..4912131) 1 NC_010612.1 coenzyme F420-dependent oxidoreductase 4912131 6228253 MMAR_3978 Mycobacterium marinum M coenzyme F420-dependent oxidoreductase YP_001852241.1 4911283 R 216594 CDS YP_001852242.1 183983951 6228254 4912215..4913270 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 4913270 6228254 MMAR_3979 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001852242.1 4912215 D 216594 CDS YP_001852243.1 183983952 6228255 4913267..4914376 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 4914376 6228255 MMAR_3980 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001852243.1 4913267 D 216594 CDS YP_001852244.1 183983953 6228256 4914380..4915537 1 NC_010612.1 function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase FadE17 4915537 fadE17_2 6228256 fadE17_2 Mycobacterium marinum M acyl-CoA dehydrogenase FadE17 YP_001852244.1 4914380 D 216594 CDS YP_001852245.1 183983954 6228257 4915534..4916469 1 NC_010612.1 function unknown role in lipid metabolism; acyl-CoA dehydrogenase 4916469 6228257 MMAR_3982 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001852245.1 4915534 D 216594 CDS YP_001852246.1 183983955 6228258 4916466..4917959 1 NC_010612.1 function unknown, but involved in lipid degradation; fatty-acid-CoA ligase 4917959 6228258 MMAR_3983 Mycobacterium marinum M fatty-acid-CoA ligase YP_001852246.1 4916466 D 216594 CDS YP_001852247.1 183983956 6228259 4918164..4919948 1 NC_010612.1 PPE family protein 4919948 6228259 MMAR_3984 Mycobacterium marinum M PPE family protein YP_001852247.1 4918164 D 216594 CDS YP_001852248.1 183983957 6228260 4920249..4920617 1 NC_010612.1 hypothetical protein 4920617 6228260 MMAR_3985 Mycobacterium marinum M hypothetical protein YP_001852248.1 4920249 D 216594 CDS YP_001852249.1 183983958 6228261 4920837..4921313 1 NC_010612.1 function unknown but contains a ricin-type beta- trefoil domain; hypothetical protein 4921313 6228261 MMAR_3986 Mycobacterium marinum M hypothetical protein YP_001852249.1 4920837 D 216594 CDS YP_001852250.1 183983959 6228262 4921480..4922499 1 NC_010612.1 function unknown. possibly involved in transcriptional mechanism; putative transcriptional regulatory protein 4922499 6228262 MMAR_3987 Mycobacterium marinum M putative transcriptional regulatory protein YP_001852250.1 4921480 D 216594 CDS YP_001852251.1 183983960 6228263 4922571..4923776 1 NC_010612.1 metal-dependent hydrolase 4923776 6228263 MMAR_3988 Mycobacterium marinum M metal-dependent hydrolase YP_001852251.1 4922571 D 216594 CDS YP_001852252.1 183983961 6228264 complement(4923912..4925726) 1 NC_010612.1 PPE family protein 4925726 6228264 MMAR_3989 Mycobacterium marinum M PPE family protein YP_001852252.1 4923912 R 216594 CDS YP_001852253.1 183983962 6228265 complement(4925723..4926034) 1 NC_010612.1 PE-PGRS family protein 4926034 6228265 MMAR_3990 Mycobacterium marinum M PE-PGRS family protein YP_001852253.1 4925723 R 216594 CDS YP_001852254.1 183983963 6228266 4927214..4929175 1 NC_010612.1 may be involved in regulation of SigG; regulator of sigma subunit, anti-anti-sigma factor RsbU 4929175 rsbU 6228266 rsbU Mycobacterium marinum M regulator of sigma subunit, anti-anti-sigma factor RsbU YP_001852254.1 4927214 D 216594 CDS YP_001852255.1 183983964 6228267 complement(4929188..4930423) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 4930423 6228267 MMAR_3992 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001852255.1 4929188 R 216594 CDS YP_001852256.1 183983965 6228268 complement(4930420..4931580) 1 NC_010612.1 function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase 4931580 6228268 MMAR_3993 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001852256.1 4930420 R 216594 CDS YP_001852257.1 183983966 6228269 4931749..4932573 1 NC_010612.1 hypothetical protein 4932573 6228269 MMAR_3994 Mycobacterium marinum M hypothetical protein YP_001852257.1 4931749 D 216594 CDS YP_001852258.1 183983967 6228270 4932570..4933232 1 NC_010612.1 hypothetical protein 4933232 6228270 MMAR_3995 Mycobacterium marinum M hypothetical protein YP_001852258.1 4932570 D 216594 CDS YP_001852259.1 183983968 6228271 4933516..4934742 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 187A4 Cyp187A4 4934742 cyp187A4 6228271 cyp187A4 Mycobacterium marinum M cytochrome P450 187A4 Cyp187A4 YP_001852259.1 4933516 D 216594 CDS YP_001852260.1 183983969 6228272 4934739..4935893 1 NC_010612.1 thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]; zinc-containing alcohol dehydrogenase NAD dependent AdhB 4935893 adhB_1 6228272 adhB_1 Mycobacterium marinum M zinc-containing alcohol dehydrogenase NAD dependent AdhB YP_001852260.1 4934739 D 216594 CDS YP_001852261.1 183983970 6228273 complement(4935923..4936750) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; short chain dehydrogenase 4936750 6228273 MMAR_3998 Mycobacterium marinum M short chain dehydrogenase YP_001852261.1 4935923 R 216594 CDS YP_001852262.1 183983971 6228274 complement(4936856..4938088) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 108B4 Cyp108B4 4938088 cyp108B4 6228274 cyp108B4 Mycobacterium marinum M cytochrome P450 108B4 Cyp108B4 YP_001852262.1 4936856 R 216594 CDS YP_001852263.1 183983972 6228275 4938279..4939775 1 NC_010612.1 key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA.]; propionyl-CoA carboxylase beta chain 4 AccD4_2 4939775 accD4_2 6228275 accD4_2 Mycobacterium marinum M propionyl-CoA carboxylase beta chain 4 AccD4_2 YP_001852263.1 4938279 D 216594 CDS YP_001852264.1 183983973 6228276 complement(4939765..4940421) 1 NC_010612.1 dehydrogenase/decarboxylase protein 4940421 6228276 MMAR_4001 Mycobacterium marinum M dehydrogenase/decarboxylase protein YP_001852264.1 4939765 R 216594 CDS YP_001852265.1 183983974 6228277 complement(4940442..4941335) 1 NC_010612.1 function unknown; contains full length of an uncharacterized homolog of a gamma-carboxymuconolactone decarboxylase subunit; dehydrogenase/decarboxylase protein 4941335 6228277 MMAR_4002 Mycobacterium marinum M dehydrogenase/decarboxylase protein YP_001852265.1 4940442 R 216594 CDS YP_001852266.1 183983975 6228278 complement(4941498..4942544) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 4942544 6228278 MMAR_4003 Mycobacterium marinum M oxidoreductase YP_001852266.1 4941498 R 216594 CDS YP_001852267.1 183983976 6228279 complement(4942541..4942924) 1 NC_010612.1 function unknown but contains a Ntf2-like superfmaily domain; hypothetical protein 4942924 6228279 MMAR_4004 Mycobacterium marinum M hypothetical protein YP_001852267.1 4942541 R 216594 CDS YP_001852268.1 183983977 6228280 complement(4942921..4943157) 1 NC_010612.1 hypothetical protein 4943157 6228280 MMAR_4005 Mycobacterium marinum M hypothetical protein YP_001852268.1 4942921 R 216594 CDS YP_001852269.1 183983978 6228281 4943288..4943905 1 NC_010612.1 function unknown but contains thioesterase/thiol ester dehydrase-isomerase superfmaily domain; hypothetical protein 4943905 6228281 MMAR_4006 Mycobacterium marinum M hypothetical protein YP_001852269.1 4943288 D 216594 CDS YP_001852270.1 183983979 6228282 4943993..4945636 1 NC_010612.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase 4945636 fadD19_2 6228282 fadD19_2 Mycobacterium marinum M acyl-CoA synthetase YP_001852270.1 4943993 D 216594 CDS YP_001852271.1 183983980 6228283 4945715..4946929 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 187A5 Cyp187A5 4946929 cyp187A5 6228283 cyp187A5 Mycobacterium marinum M cytochrome P450 187A5 Cyp187A5 YP_001852271.1 4945715 D 216594 CDS YP_001852272.1 183983981 6228284 4946938..4948152 1 NC_010612.1 dehydratase 4948152 6228284 MMAR_4009 Mycobacterium marinum M dehydratase YP_001852272.1 4946938 D 216594 CDS YP_001852273.1 183983982 6228285 complement(4948174..4949355) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 4949355 6228285 MMAR_4010 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001852273.1 4948174 R 216594 CDS YP_001852274.1 183983983 6228286 complement(4949370..4950434) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 4950434 6228286 MMAR_4011 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001852274.1 4949370 R 216594 CDS YP_001852275.1 183983984 6228287 complement(4950431..4951267) 1 NC_010612.1 metal-dependent hydrolase 4951267 6228287 MMAR_4012 Mycobacterium marinum M metal-dependent hydrolase YP_001852275.1 4950431 R 216594 CDS YP_001852276.1 183983985 6228288 complement(4951264..4952904) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase 4952904 6228288 MMAR_4013 Mycobacterium marinum M acyl-CoA synthetase YP_001852276.1 4951264 R 216594 CDS YP_001852277.1 183983986 6228289 complement(4952918..4954123) 1 NC_010612.1 metal-dependent hydrolase 4954123 6228289 MMAR_4014 Mycobacterium marinum M metal-dependent hydrolase YP_001852277.1 4952918 R 216594 CDS YP_001852278.1 183983987 6228290 complement(4954152..4954988) 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 4954988 echA12_1 6228290 echA12_1 Mycobacterium marinum M enoyl-CoA hydratase YP_001852278.1 4954152 R 216594 CDS YP_001852279.1 183983988 6228292 complement(4956085..4956729) 1 NC_010612.1 hypothetical protein 4956729 6228292 MMAR_4017 Mycobacterium marinum M hypothetical protein YP_001852279.1 4956085 R 216594 CDS YP_001852280.1 183983989 6228293 4956950..4957279 1 NC_010612.1 hypothetical protein 4957279 6228293 MMAR_4018 Mycobacterium marinum M hypothetical protein YP_001852280.1 4956950 D 216594 CDS YP_001852281.1 183983990 6228294 4957684..4958487 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 4958487 6228294 MMAR_4019 Mycobacterium marinum M transcriptional regulatory protein YP_001852281.1 4957684 D 216594 CDS YP_001852282.1 183983991 6228295 complement(4958500..4959396) 1 NC_010612.1 oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA4_2 4959396 echA4_2 6228295 echA4_2 Mycobacterium marinum M enoyl-CoA hydratase, EchA4_2 YP_001852282.1 4958500 R 216594 CDS YP_001852283.1 183983992 6228296 complement(4959393..4960067) 1 NC_010612.1 hypothetical protein 4960067 6228296 MMAR_4021 Mycobacterium marinum M hypothetical protein YP_001852283.1 4959393 R 216594 CDS YP_001852284.1 183983993 6228297 4960187..4961005 1 NC_010612.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase EchA10 4961005 echA10_1 6228297 echA10_1 Mycobacterium marinum M enoyl-CoA hydratase EchA10 YP_001852284.1 4960187 D 216594 CDS YP_001852285.1 183983994 6228298 4961008..4961820 1 NC_010612.1 oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase EchA11 4961820 echA11_1 6228298 echA11_1 Mycobacterium marinum M enoyl-CoA hydratase EchA11 YP_001852285.1 4961008 D 216594 CDS YP_001852286.1 183983995 6228299 4961817..4962626 1 NC_010612.1 oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase EchA16 4962626 echA16_1 6228299 echA16_1 Mycobacterium marinum M enoyl-CoA hydratase EchA16 YP_001852286.1 4961817 D 216594 CDS YP_001852287.1 183983996 6228300 4962626..4964107 1 NC_010612.1 function unknown, but supposed involvement in lipid degradation; long-chain fatty-acid CoA ligase 4964107 6228300 MMAR_4025 Mycobacterium marinum M long-chain fatty-acid CoA ligase YP_001852287.1 4962626 D 216594 CDS YP_001852288.1 183983997 6228301 4964097..4965695 1 NC_010612.1 involved in lipid degradation; fatty-acid-CoA ligase FadD35 4965695 fadD35_1 6228301 fadD35_1 Mycobacterium marinum M fatty-acid-CoA ligase FadD35 YP_001852288.1 4964097 D 216594 CDS YP_001852289.1 183983998 6228302 4965688..4967214 1 NC_010612.1 function unknown, but involved in lipid degradation; fatty-acid-CoA ligase 4967214 6228302 MMAR_4027 Mycobacterium marinum M fatty-acid-CoA ligase YP_001852289.1 4965688 D 216594 CDS YP_001852290.1 183983999 6228303 complement(4967531..4967896) 1 NC_010612.1 hypothetical protein 4967896 6228303 MMAR_4028 Mycobacterium marinum M hypothetical protein YP_001852290.1 4967531 R 216594 CDS YP_001852291.1 183984000 6228304 complement(4968097..4968810) 1 NC_010612.1 possibly involved in transcriptional mechanism; GntR family transcriptional regulator 4968810 6228304 MMAR_4029 Mycobacterium marinum M GntR family transcriptional regulator YP_001852291.1 4968097 R 216594 CDS YP_001852292.1 183984001 6228305 complement(4968824..4970017) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 4970017 6228305 MMAR_4030 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001852292.1 4968824 R 216594 CDS YP_001852293.1 183984002 6228306 complement(4970014..4971243) 1 NC_010612.1 function unknown, but supposed involvement in lipid degradation; acyl-CoA transferase/carnitine dehydratase 4971243 6228306 MMAR_4031 Mycobacterium marinum M acyl-CoA transferase/carnitine dehydratase YP_001852293.1 4970014 R 216594 CDS YP_001852294.1 183984003 6228307 complement(4971246..4972469) 1 NC_010612.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 4972469 6228307 MMAR_4032 Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001852294.1 4971246 R 216594 CDS YP_001852295.1 183984004 6228308 complement(4972466..4973212) 1 NC_010612.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 4973212 fabG 6228308 fabG Mycobacterium marinum M 3-ketoacyl-ACP reductase YP_001852295.1 4972466 R 216594 CDS YP_001852296.1 183984005 6228309 4973331..4974494 1 NC_010612.1 function unknown, but involved in lipid metabolism [catalytic activity: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF]; acyl-CoA dehydrogenase FadE 4974494 fadE 6228309 fadE Mycobacterium marinum M acyl-CoA dehydrogenase FadE YP_001852296.1 4973331 D 216594 CDS YP_001852297.1 183984006 6228310 complement(4974497..4975564) 1 NC_010612.1 function unknown but contains a protein-kinase superfamily domain; hypothetical protein 4975564 6228310 MMAR_4035 Mycobacterium marinum M hypothetical protein YP_001852297.1 4974497 R 216594 CDS YP_001852298.1 183984007 6228311 complement(4975618..4977357) 1 NC_010612.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 4977357 6228311 MMAR_4036 Mycobacterium marinum M transmembrane ABC transporter ATP-binding protein YP_001852298.1 4975618 R 216594 CDS YP_001852299.1 183984008 6228312 complement(4977354..4979978) 1 NC_010612.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 4979978 6228312 MMAR_4037 Mycobacterium marinum M transmembrane ABC transporter ATP-binding protein YP_001852299.1 4977354 R 216594 CDS YP_001852300.1 183984009 6228314 4980715..4981107 1 NC_010612.1 lipoprotein LprD 4981107 lprD 6228314 lprD Mycobacterium marinum M lipoprotein LprD YP_001852300.1 4980715 D 216594 CDS YP_001852301.1 183984010 6228315 4981104..4981466 1 NC_010612.1 hypothetical protein 4981466 6228315 MMAR_4039 Mycobacterium marinum M hypothetical protein YP_001852301.1 4981104 D 216594 CDS YP_001852302.1 183984011 6228316 complement(4981491..4982102) 1 NC_010612.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 4982102 6228316 MMAR_4040 Mycobacterium marinum M putative deoxyribonucleotide triphosphate pyrophosphatase YP_001852302.1 4981491 R 216594 CDS YP_001852303.1 183984012 6228317 complement(4982258..4982800) 1 NC_010612.1 hypothetical protein 4982800 6228317 MMAR_4041 Mycobacterium marinum M hypothetical protein YP_001852303.1 4982258 R 216594 CDS YP_001852304.1 183984013 6228318 complement(4983081..4983911) 1 NC_010612.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 4983911 rph 6228318 rph Mycobacterium marinum M ribonuclease PH YP_001852304.1 4983081 R 216594 CDS YP_001852305.1 183984014 6228319 complement(4983962..4984729) 1 NC_010612.1 metal-dependent hydrolase 4984729 6228319 MMAR_4043 Mycobacterium marinum M metal-dependent hydrolase YP_001852305.1 4983962 R 216594 CDS YP_001852306.1 183984015 6228320 complement(4984735..4984914) 1 NC_010612.1 hypothetical protein 4984914 6228320 MMAR_4044 Mycobacterium marinum M hypothetical protein YP_001852306.1 4984735 R 216594 CDS YP_001852307.1 183984016 6228321 4985113..4985844 1 NC_010612.1 hypothetical protein 4985844 6228321 MMAR_4045 Mycobacterium marinum M hypothetical protein YP_001852307.1 4985113 D 216594 CDS YP_001852308.1 183984017 6228322 complement(4986111..4988438) 1 NC_010612.1 involved in energy metabolism; contributes to acetyl-CoA production as part of pyruvate dehydrogenase complex [catalytic activity: pyruvate + lipoamide = S- acetyl-dihydro-lipoamide + CO(2)]; pyruvate dehydrogenase E1 component AceE 4988438 aceE_1 6228322 aceE_1 Mycobacterium marinum M pyruvate dehydrogenase E1 component AceE YP_001852308.1 4986111 R 216594 CDS YP_001852309.1 183984018 6228323 4988577..4989065 1 NC_010612.1 involved in transcriptional mechanism; Lrp/AsnC family transcriptional regulator 4989065 6228323 MMAR_4047 Mycobacterium marinum M Lrp/AsnC family transcriptional regulator YP_001852309.1 4988577 D 216594 CDS YP_001852310.1 183984019 6228324 4989432..4989932 1 NC_010612.1 hypothetical protein 4989932 6228324 MMAR_4048 Mycobacterium marinum M hypothetical protein YP_001852310.1 4989432 D 216594 CDS YP_001852311.1 183984020 6228325 4990695..4991462 1 NC_010612.1 integral membrane protein YrbE3A 4991462 yrbE3A_1 6228325 yrbE3A_1 Mycobacterium marinum M integral membrane protein YrbE3A YP_001852311.1 4990695 D 216594 CDS YP_001852312.1 183984021 6228326 4991459..4992313 1 NC_010612.1 integral membrane protein YrbE3B 4992313 yrbE3B_1 6228326 yrbE3B_1 Mycobacterium marinum M integral membrane protein YrbE3B YP_001852312.1 4991459 D 216594 CDS YP_001852313.1 183984022 6228327 4992318..4993778 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3A 4993778 mce3A_1 6228327 mce3A_1 Mycobacterium marinum M MCE-family protein Mce3A YP_001852313.1 4992318 D 216594 CDS YP_001852314.1 183984023 6228328 4993858..4994889 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3B 4994889 mce3B_1 6228328 mce3B_1 Mycobacterium marinum M MCE-family protein Mce3B YP_001852314.1 4993858 D 216594 CDS YP_001852315.1 183984024 6228329 4994886..4996202 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein, Mce3C 4996202 mce3C_1 6228329 mce3C_1 Mycobacterium marinum M MCE-family protein, Mce3C YP_001852315.1 4994886 D 216594 CDS YP_001852316.1 183984025 6228330 4996199..4997545 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce3D 4997545 mce3D_1 6228330 mce3D_1 Mycobacterium marinum M MCE-family protein Mce3D YP_001852316.1 4996199 D 216594 CDS YP_001852317.1 183984026 6228331 4997542..4998687 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE family lipoprotein LprM 4998687 lprM_1 6228331 lprM_1 Mycobacterium marinum M MCE family lipoprotein LprM YP_001852317.1 4997542 D 216594 CDS YP_001852318.1 183984027 6228332 4998689..5000146 1 NC_010612.1 function unknown, but thought involved in host cell invasion; MCE-family protein Mce3F 5000146 mce3F_1 6228332 mce3F_1 Mycobacterium marinum M MCE-family protein Mce3F YP_001852318.1 4998689 D 216594 CDS YP_001852319.1 183984028 6228333 5000143..5000856 1 NC_010612.1 Mce associated membrane protein 5000856 6228333 MMAR_4057 Mycobacterium marinum M Mce associated membrane protein YP_001852319.1 5000143 D 216594 CDS YP_001852320.1 183984029 6228334 complement(5000899..5001714) 1 NC_010612.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 5001714 murI 6228334 murI Mycobacterium marinum M glutamate racemase YP_001852320.1 5000899 R 216594 CDS YP_001852321.1 183984030 6228335 complement(5001711..5002379) 1 NC_010612.1 function unknown; contains a C-term rhomboid-family domain. these proteins contain three strongly conserved histidines in the putative transmembrane regions that may be involved in peptidase functions; integral membrane protein 5002379 6228335 MMAR_4059 Mycobacterium marinum M integral membrane protein YP_001852321.1 5001711 R 216594 CDS YP_001852322.1 183984031 6228336 5002902..5003201 1 NC_010612.1 hypothetical protein 5003201 6228336 MMAR_4060 Mycobacterium marinum M hypothetical protein YP_001852322.1 5002902 D 216594 CDS YP_001852323.1 183984032 6228337 5003202..5004212 1 NC_010612.1 hypothetical protein 5004212 6228337 MMAR_4061 Mycobacterium marinum M hypothetical protein YP_001852323.1 5003202 D 216594 CDS YP_001852324.1 183984033 6228338 5004217..5004636 1 NC_010612.1 function unknown; contains signal peptide; hypothetical protein 5004636 6228338 MMAR_4062 Mycobacterium marinum M hypothetical protein YP_001852324.1 5004217 D 216594 CDS YP_001852325.1 183984034 6228339 complement(5004830..5005102) 1 NC_010612.1 putative antigen Cfp10A 5005102 cfp10A 6228339 cfp10A Mycobacterium marinum M putative antigen Cfp10A YP_001852325.1 5004830 R 216594 CDS YP_001852326.1 183984035 6228340 complement(5005124..5005537) 1 NC_010612.1 function unknown but domain identity suggests this CDS encodes a metal-dependent protease of the Pad1/Jab1 superfamily; hypothetical protein 5005537 6228340 MMAR_4064 Mycobacterium marinum M hypothetical protein YP_001852326.1 5005124 R 216594 CDS YP_001852327.1 183984036 6228341 complement(5005539..5006627) 1 NC_010612.1 function unknown, probable role in amino acid hydrolysis; L-aminopeptidase/D-esterase DmpA 5006627 dmpA 6228341 dmpA Mycobacterium marinum M L-aminopeptidase/D-esterase DmpA YP_001852327.1 5005539 R 216594 CDS YP_001852328.1 183984037 6228342 complement(5006624..5007211) 1 NC_010612.1 hypothetical protein 5007211 6228342 MMAR_4066 Mycobacterium marinum M hypothetical protein YP_001852328.1 5006624 R 216594 CDS YP_001852329.1 183984038 6228343 complement(5007236..5007541) 1 NC_010612.1 function unknown but contains a ClpS domain suggesting a function related to ATP-dependent protein degradation; hypothetical protein 5007541 6228343 MMAR_4067 Mycobacterium marinum M hypothetical protein YP_001852329.1 5007236 R 216594 CDS YP_001852330.1 183984039 6228344 5007607..5008923 1 NC_010612.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 5008923 pncB 6228344 pncB Mycobacterium marinum M nicotinate phosphoribosyltransferase YP_001852330.1 5007607 D 216594 CDS YP_001852331.1 183984040 6228345 5008959..5010980 1 NC_010612.1 probable helicase involved in DNA repair and perhaps also replication; ATP-dependent helicase DinG 5010980 dinG 6228345 dinG Mycobacterium marinum M ATP-dependent helicase DinG YP_001852331.1 5008959 D 216594 CDS YP_001852332.1 183984041 6228346 complement(5010977..5013568) 1 NC_010612.1 catalytic activity : {(1,4)-alpha-D-glucosyl}(N) + phosphate = {(1,4)-alpha-D-glucosyl}(N-1) + alpha-D- glucose 1-phosphate; glycogen phosphorylase GlgP 5013568 glgP 6228346 glgP Mycobacterium marinum M glycogen phosphorylase GlgP YP_001852332.1 5010977 R 216594 CDS YP_001852333.1 183984042 6228347 5013758..5015845 1 NC_010612.1 function unknown, may be involved in polysaccharide degradation; glycosidase 5015845 6228347 MMAR_4071 Mycobacterium marinum M glycosidase YP_001852333.1 5013758 D 216594 CDS YP_001852334.1 183984043 6228348 5015852..5018047 1 NC_010612.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 5018047 glgB 6228348 glgB Mycobacterium marinum M glycogen branching protein YP_001852334.1 5015852 D 216594 CDS YP_001852335.1 183984044 6228349 complement(5018058..5019029) 1 NC_010612.1 transposition of ISMyma04; transposase for ISMyma04 5019029 6228349 MMAR_4073 Mycobacterium marinum M transposase for ISMyma04 YP_001852335.1 5018058 R 216594 CDS YP_001852336.1 183984045 6228350 complement(5019205..5020119) 1 NC_010612.1 thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions; thioredoxin 5020119 6228350 MMAR_4074 Mycobacterium marinum M thioredoxin YP_001852336.1 5019205 R 216594 CDS YP_001852337.1 183984046 6228351 complement(5020297..5021478) 1 NC_010612.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 5021478 fadA4 6228351 fadA4 Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001852337.1 5020297 R 216594 CDS YP_001852338.1 183984047 6228352 5021561..5022028 1 NC_010612.1 glyoxalase I (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway; glyoxalase GloA 5022028 gloA_1 6228352 gloA_1 Mycobacterium marinum M glyoxalase GloA YP_001852338.1 5021561 D 216594 CDS YP_001852339.1 183984048 6228353 complement(5022341..5023012) 1 NC_010612.1 function unknown but contains a predicted nuclease domain of the RecB family; hypothetical protein 5023012 6228353 MMAR_4077 Mycobacterium marinum M hypothetical protein YP_001852339.1 5022341 R 216594 CDS YP_001852340.1 183984049 6228354 5023058..5024710 1 NC_010612.1 thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]; adenylate cyclase 5024710 6228354 MMAR_4078 Mycobacterium marinum M adenylate cyclase YP_001852340.1 5023058 D 216594 CDS YP_001852341.1 183984050 6228355 5024855..5026459 1 NC_010612.1 thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]; adenylate cyclase 5026459 6228355 MMAR_4079 Mycobacterium marinum M adenylate cyclase YP_001852341.1 5024855 D 216594 CDS YP_001852342.1 183984051 6228356 5026591..5028210 1 NC_010612.1 thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]; adenylate cyclase 5028210 6228356 MMAR_4080 Mycobacterium marinum M adenylate cyclase YP_001852342.1 5026591 D 216594 CDS YP_001852343.1 183984052 6228357 5028263..5029780 1 NC_010612.1 involved in damage reversal and in base excision repair. the methylated Ada protein acts as a positive regulator of its own synthesis, as well as that of other proteins. the transcription-activating function of the Ada protein resides in its N-terminus. repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. this is a suicide reaction: the enzyme is irreversibly inactivated. can also repair O-4- methylthymine [catalytic activity: DNA (containing 6-O- methylguanine) + [protein]-L-cysteine = DNA (without 6-O- methylguanine) + protein S-methyl-L-cysteine]; Ada regulatory protein AlkA 5029780 alkA 6228357 alkA Mycobacterium marinum M Ada regulatory protein AlkA YP_001852343.1 5028263 D 216594 CDS YP_001852344.1 183984053 6228358 5029777..5030295 1 NC_010612.1 repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. this is a suicide reaction: the enzyme is irreversibly inactivated [catalytic activity : DNA (containing 6-O-methylguanine) + [protein]-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.]; methylated-DNA--protein-cysteine methyltransferase Ogt 5030295 ogt 6228358 ogt Mycobacterium marinum M methylated-DNA--protein-cysteine methyltransferase Ogt YP_001852344.1 5029777 D 216594 CDS YP_001852345.1 183984054 6228362 complement(5035745..5036998) 1 NC_010612.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 5036998 murA 6228362 murA Mycobacterium marinum M UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_001852345.1 5035745 R 216594 CDS YP_001852346.1 183984055 6228363 5037069..5037662 1 NC_010612.1 these proteins convert inactive cobalamins to AdoCbl for 1,2-propanediol degradation; cobalamin adenosyltransferase 5037662 6228363 MMAR_4084 Mycobacterium marinum M cobalamin adenosyltransferase YP_001852346.1 5037069 D 216594 CDS YP_001852347.1 183984056 6228364 complement(5037753..5038196) 1 NC_010612.1 hypothetical protein 5038196 6228364 MMAR_4085 Mycobacterium marinum M hypothetical protein YP_001852347.1 5037753 R 216594 CDS YP_001852348.1 183984057 6228365 complement(5038204..5038569) 1 NC_010612.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 5038569 atpC 6228365 atpC Mycobacterium marinum M F0F1 ATP synthase subunit epsilon YP_001852348.1 5038204 R 216594 CDS YP_001852349.1 183984058 6228366 complement(5038606..5040057) 1 NC_010612.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 5040057 atpD 6228366 atpD Mycobacterium marinum M F0F1 ATP synthase subunit beta YP_001852349.1 5038606 R 216594 CDS YP_001852350.1 183984059 6228367 complement(5040086..5041000) 1 NC_010612.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 5041000 atpG 6228367 atpG Mycobacterium marinum M F0F1 ATP synthase subunit gamma YP_001852350.1 5040086 R 216594 CDS YP_001852351.1 183984060 6228368 complement(5041019..5042668) 1 NC_010612.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 5042668 atpA 6228368 atpA Mycobacterium marinum M F0F1 ATP synthase subunit alpha YP_001852351.1 5041019 R 216594 CDS YP_001852352.1 183984061 6228369 complement(5042730..5044067) 1 NC_010612.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 5044067 atpH 6228369 atpH Mycobacterium marinum M F0F1 ATP synthase subunit delta YP_001852352.1 5042730 R 216594 CDS YP_001852353.1 183984062 6228370 complement(5044074..5044586) 1 NC_010612.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 5044586 atpF 6228370 atpF Mycobacterium marinum M F0F1 ATP synthase subunit B YP_001852353.1 5044074 R 216594 CDS YP_001852354.1 183984063 6228371 complement(5044628..5044873) 1 NC_010612.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 5044873 atpE 6228371 atpE Mycobacterium marinum M F0F1 ATP synthase subunit C YP_001852354.1 5044628 R 216594 CDS YP_001852355.1 183984064 6228372 complement(5044964..5045716) 1 NC_010612.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 5045716 atpB 6228372 atpB Mycobacterium marinum M F0F1 ATP synthase subunit A YP_001852355.1 5044964 R 216594 CDS YP_001852356.1 183984065 6228373 complement(5045709..5046209) 1 NC_010612.1 hypothetical protein 5046209 6228373 MMAR_4094 Mycobacterium marinum M hypothetical protein YP_001852356.1 5045709 R 216594 CDS YP_001852357.1 183984066 6228374 complement(5046460..5047638) 1 NC_010612.1 catalysis of the first step of the lipid cycle reactions in the biosynthesis of cell wall peptidoglycan; undecapaprenyl-phosphate alpha-N- acetylglucosaminyltransferase Rfe 5047638 rfe 6228374 rfe Mycobacterium marinum M undecapaprenyl-phosphate alpha-N- acetylglucosaminyltransferase Rfe YP_001852357.1 5046460 R 216594 CDS YP_001852358.1 183984067 6228375 complement(5047720..5048370) 1 NC_010612.1 function unknown but contains YrdC domain. this domain has been shown to preferentially bind to dsRNA; hypothetical protein 5048370 6228375 MMAR_4096 Mycobacterium marinum M hypothetical protein YP_001852358.1 5047720 R 216594 CDS YP_001852359.1 183984068 6228376 complement(5048423..5049271) 1 NC_010612.1 function unknown but may have S-adenosyl-methionine- dependent methyltransferase activity; modification methylase HemK 5049271 hemK 6228376 hemK Mycobacterium marinum M modification methylase HemK YP_001852359.1 5048423 R 216594 CDS YP_001852360.1 183984069 6228377 complement(5049268..5050341) 1 NC_010612.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 5050341 prfA 6228377 prfA Mycobacterium marinum M peptide chain release factor 1 YP_001852360.1 5049268 R 216594 CDS YP_001852361.1 183984070 6228378 complement(5050429..5050674) 1 NC_010612.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 5050674 rpmE 6228378 rpmE Mycobacterium marinum M 50S ribosomal protein L31 YP_001852361.1 5050429 R 216594 CDS YP_001852362.1 183984071 6228379 complement(5050866..5052731) 1 NC_010612.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 5052731 rho 6228379 rho Mycobacterium marinum M transcription termination factor Rho YP_001852362.1 5050866 R 216594 CDS YP_001852363.1 183984072 6228380 complement(5052998..5053942) 1 NC_010612.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 5053942 thrB 6228380 thrB Mycobacterium marinum M homoserine kinase YP_001852363.1 5052998 R 216594 CDS YP_001852364.1 183984073 6228381 complement(5053998..5055080) 1 NC_010612.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 5055080 thrC 6228381 thrC Mycobacterium marinum M threonine synthase YP_001852364.1 5053998 R 216594 CDS YP_001852365.1 183984074 6228382 complement(5055077..5056402) 1 NC_010612.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 5056402 thrA 6228382 thrA Mycobacterium marinum M homoserine dehydrogenase YP_001852365.1 5055077 R 216594 CDS YP_001852366.1 183984075 6228383 complement(5056406..5057824) 1 NC_010612.1 involved in biosynthesis of lysine (last step) [catalytic activity : meso-2,6-diaminoheptanedioate = L- lysine + CO(2)]; diaminopimelate decarboxylase LysA 5057824 lysA 6228383 lysA Mycobacterium marinum M diaminopimelate decarboxylase LysA YP_001852366.1 5056406 R 216594 CDS YP_001852367.1 183984076 6228384 complement(5057821..5059473) 1 NC_010612.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 5059473 argS 6228384 argS Mycobacterium marinum M arginyl-tRNA synthetase YP_001852367.1 5057821 R 216594 CDS YP_001852368.1 183984077 6228386 5059968..5061524 1 NC_010612.1 transposition of ISMyma05; transposase for ISMyma05 5061524 6228386 MMAR_4106 Mycobacterium marinum M transposase for ISMyma05 YP_001852368.1 5059968 D 216594 CDS YP_001852369.1 183984078 6228387 5062415..5062711 1 NC_010612.1 hypothetical protein 5062711 6228387 MMAR_4107 Mycobacterium marinum M hypothetical protein YP_001852369.1 5062415 D 216594 CDS YP_001852370.1 183984079 6228389 5063642..5063917 1 NC_010612.1 hypothetical protein 5063917 6228389 MMAR_5576 Mycobacterium marinum M hypothetical protein YP_001852370.1 5063642 D 216594 CDS YP_001852371.1 183984080 6228390 complement(5064070..5064588) 1 NC_010612.1 PE-PGRS family protein 5064588 6228390 MMAR_4109 Mycobacterium marinum M PE-PGRS family protein YP_001852371.1 5064070 R 216594 CDS YP_001852372.1 183984081 6228391 5065092..5067761 1 NC_010612.1 this family of dehydrogenases act on aldehyde substrates. members use NADP as a cofactor; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 5067761 6228391 MMAR_4110 Mycobacterium marinum M bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_001852372.1 5065092 D 216594 CDS YP_001852373.1 183984082 6228392 complement(5067727..5068134) 1 NC_010612.1 pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate; pyridoxamine 5'-phosphate oxidase 5068134 6228392 MMAR_4111 Mycobacterium marinum M pyridoxamine 5'-phosphate oxidase YP_001852373.1 5067727 R 216594 CDS YP_001852374.1 183984083 6228393 complement(5068200..5068559) 1 NC_010612.1 function unknown but contains YCII-related protein domain; hypothetical protein 5068559 6228393 MMAR_4112 Mycobacterium marinum M hypothetical protein YP_001852374.1 5068200 R 216594 CDS YP_001852375.1 183984084 6228394 complement(5068552..5069424) 1 NC_010612.1 catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide; haloalkane dehalogenase 5069424 dhaA 6228394 dhaA Mycobacterium marinum M haloalkane dehalogenase YP_001852375.1 5068552 R 216594 CDS YP_001852376.1 183984085 6228395 complement(5069475..5071265) 1 NC_010612.1 cleaves xaa-pro-releasing N-terminal dipeptides; peptidase S15 5071265 6228395 MMAR_5521 Mycobacterium marinum M peptidase S15 YP_001852376.1 5069475 R 216594 CDS YP_001852377.1 183984086 6228396 5071407..5072054 1 NC_010612.1 function unknown but belongs to the TetR family of bacterial transcriptional regulatory proteins; putative regulatory protein 5072054 6228396 MMAR_4115 Mycobacterium marinum M putative regulatory protein YP_001852377.1 5071407 D 216594 CDS YP_001852378.1 183984087 6228397 complement(5072064..5072576) 1 NC_010612.1 PE-PGRS family protein 5072576 6228397 MMAR_4116 Mycobacterium marinum M PE-PGRS family protein YP_001852378.1 5072064 R 216594 CDS YP_001852379.1 183984088 6228398 complement(5072707..5073612) 1 NC_010612.1 function unknown, belongs to the LysR family of transcriptional regulators; putative regulatory protein 5073612 6228398 MMAR_4117 Mycobacterium marinum M putative regulatory protein YP_001852379.1 5072707 R 216594 CDS YP_001852380.1 183984089 6228399 5073703..5075031 1 NC_010612.1 function unknown role in transport. belongs to the DMT superfamily; membrane permease 5075031 6228399 MMAR_4118 Mycobacterium marinum M membrane permease YP_001852380.1 5073703 D 216594 CDS YP_001852381.1 183984090 6228400 5074916..5075560 1 NC_010612.1 hypothetical protein 5075560 6228400 MMAR_4119 Mycobacterium marinum M hypothetical protein YP_001852381.1 5074916 D 216594 CDS YP_001852382.1 183984091 6228401 5075758..5077341 1 NC_010612.1 thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]; adenylate cyclase 5077341 6228401 MMAR_4120 Mycobacterium marinum M adenylate cyclase YP_001852382.1 5075758 D 216594 CDS YP_001852383.1 183984092 6228402 5077507..5077848 1 NC_010612.1 hypothetical protein 5077848 6228402 MMAR_4121 Mycobacterium marinum M hypothetical protein YP_001852383.1 5077507 D 216594 CDS YP_001852384.1 183984093 6228403 5078080..5079558 1 NC_010612.1 hypothetical protein 5079558 6228403 MMAR_4122 Mycobacterium marinum M hypothetical protein YP_001852384.1 5078080 D 216594 CDS YP_001852385.1 183984094 6228404 complement(5079599..5080225) 1 NC_010612.1 hypothetical protein 5080225 6228404 MMAR_4123 Mycobacterium marinum M hypothetical protein YP_001852385.1 5079599 R 216594 CDS YP_001852386.1 183984095 6228405 complement(5080318..5080845) 1 NC_010612.1 hypothetical protein 5080845 6228405 MMAR_4124 Mycobacterium marinum M hypothetical protein YP_001852386.1 5080318 R 216594 CDS YP_001852387.1 183984096 6228406 complement(5080996..5081532) 1 NC_010612.1 NUDIX hydrolases catalyze the hydrolysis of a variety of nucleoside diphoshate derivatives; NUDIX hydrolase 5081532 6228406 MMAR_4125 Mycobacterium marinum M NUDIX hydrolase YP_001852387.1 5080996 R 216594 CDS YP_001852388.1 183984097 6228407 5081791..5083542 1 NC_010612.1 function unknown but contains TrkA domain. this domain is found in a wide variety of proteins. these protein include potassium channels P31069, phosphoesterases Q59027, and various other transporters. this domain binds to NAD; putative transport protein 5083542 6228407 MMAR_4126 Mycobacterium marinum M putative transport protein YP_001852388.1 5081791 D 216594 CDS YP_001852389.1 183984098 6228408 complement(5083551..5084954) 1 NC_010612.1 PE-PGRS family protein 5084954 6228408 MMAR_4127 Mycobacterium marinum M PE-PGRS family protein YP_001852389.1 5083551 R 216594 CDS YP_001852390.1 183984099 6228409 complement(5085052..5085939) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; flavin-dependent oxidoreductase 5085939 6228409 MMAR_4128 Mycobacterium marinum M flavin-dependent oxidoreductase YP_001852390.1 5085052 R 216594 CDS YP_001852391.1 183984100 6228410 5085979..5086392 1 NC_010612.1 catalyzes the first step of the glyoxal pathway; glyoxalase GloA 5086392 gloA_2 6228410 gloA_2 Mycobacterium marinum M glyoxalase GloA YP_001852391.1 5085979 D 216594 CDS YP_001852392.1 183984101 6228411 5086485..5086874 1 NC_010612.1 function unknown but contains glyoxalase/bleomycin resistance protein/Dihydroxybiphenyl dioxygenase superfamily domain; hypothetical protein 5086874 6228411 MMAR_4130 Mycobacterium marinum M hypothetical protein YP_001852392.1 5086485 D 216594 CDS YP_001852393.1 183984102 6228412 complement(5086871..5087356) 1 NC_010612.1 putative transcriptional regulatory protein 5087356 6228412 MMAR_4131 Mycobacterium marinum M putative transcriptional regulatory protein YP_001852393.1 5086871 R 216594 CDS YP_001852394.1 183984103 6228413 complement(5087450..5089300) 1 NC_010612.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase 5089300 cysN 6228413 cysN Mycobacterium marinum M bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase YP_001852394.1 5087450 R 216594 CDS YP_001852395.1 183984104 6228414 complement(5089300..5090232) 1 NC_010612.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 5090232 cysD 6228414 cysD Mycobacterium marinum M sulfate adenylyltransferase subunit 2 YP_001852395.1 5089300 R 216594 CDS YP_001852396.1 183984105 6228415 5090420..5090854 1 NC_010612.1 function unknown, contains a thioesterase superfamily domain; hypothetical protein 5090854 6228415 MMAR_4134 Mycobacterium marinum M hypothetical protein YP_001852396.1 5090420 D 216594 CDS YP_001852397.1 183984106 6228416 complement(5090862..5091353) 1 NC_010612.1 domain identity to carbonic anhydrases. these are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide; carbonic anhydrase 5091353 6228416 MMAR_4135 Mycobacterium marinum M carbonic anhydrase YP_001852397.1 5090862 R 216594 CDS YP_001852398.1 183984107 6228417 5091676..5092653 1 NC_010612.1 involved in active transport of oligopeptide across the membrane (import). responsible for the translocation of the substrate across the membrane; oligopeptide-transport integral membrane protein ABC transporter OppB 5092653 oppB 6228417 oppB Mycobacterium marinum M oligopeptide-transport integral membrane protein ABC transporter OppB YP_001852398.1 5091676 D 216594 CDS YP_001852399.1 183984108 6228418 5092650..5093543 1 NC_010612.1 involved in active transport of oligopeptide across the membrane (import). responsible for the translocation of the substrate across the membrane; oligopeptide-transport integral membrane protein ABC transporter OppC 5093543 oppC 6228418 oppC Mycobacterium marinum M oligopeptide-transport integral membrane protein ABC transporter OppC YP_001852399.1 5092650 D 216594 CDS YP_001852400.1 183984109 6228419 5093540..5095378 1 NC_010612.1 involved in active transport of oligopeptide across the membrane (import). responsible for energy coupling to the transport system; oligopeptide-transport ATP-binding protein ABC transporter OppD 5095378 oppD 6228419 oppD Mycobacterium marinum M oligopeptide-transport ATP-binding protein ABC transporter OppD YP_001852400.1 5093540 D 216594 CDS YP_001852401.1 183984110 6228420 5095368..5097116 1 NC_010612.1 involved in active transport of oligopeptide across the membrane (import). this protein is a component of the oligopeptide permease, a binding protein-dependent transport system; it binds peptides up to five amino acids long with high affinity; periplasmic oligopeptide-binding lipoprotein OppA 5097116 oppA 6228420 oppA Mycobacterium marinum M periplasmic oligopeptide-binding lipoprotein OppA YP_001852401.1 5095368 D 216594 CDS YP_001852402.1 183984111 6228421 complement(5097103..5098353) 1 NC_010612.1 function unknown but contains alpha/beta-hydrolase superfamily domain; hydrolase 5098353 6228421 MMAR_4140 Mycobacterium marinum M hydrolase YP_001852402.1 5097103 R 216594 CDS YP_001852403.1 183984112 6228422 complement(5098443..5100032) 1 NC_010612.1 function unknown, probably involved in cellular metabolism, probably electron-transfer-linked; dehydrogenase fad flavoprotein GMC oxidoreductase 5100032 6228422 MMAR_4141 Mycobacterium marinum M dehydrogenase fad flavoprotein GMC oxidoreductase YP_001852403.1 5098443 R 216594 CDS YP_001852404.1 183984113 6228423 complement(5100082..5102712) 1 NC_010612.1 function unknown, contains P-loop containing nucleoside triphosphate hydrolase superfamily domain; hydrolase 5102712 6228423 MMAR_4142 Mycobacterium marinum M hydrolase YP_001852404.1 5100082 R 216594 CDS YP_001852405.1 183984114 6228424 complement(5102709..5103860) 1 NC_010612.1 function unknown: possible role in DNA replication, recombination, and repair; DNA repair exonuclease SbcD 5103860 sbcD 6228424 sbcD Mycobacterium marinum M DNA repair exonuclease SbcD YP_001852405.1 5102709 R 216594 CDS YP_001852406.1 183984115 6228425 5104146..5104649 1 NC_010612.1 function unknown, possible role in signal transduction; phosphohistidine phosphatase SixA 5104649 sixA 6228425 sixA Mycobacterium marinum M phosphohistidine phosphatase SixA YP_001852406.1 5104146 D 216594 CDS YP_001852407.1 183984116 6228426 complement(5104709..5105287) 1 NC_010612.1 lipoprotein LprC 5105287 lprC 6228426 lprC Mycobacterium marinum M lipoprotein LprC YP_001852407.1 5104709 R 216594 CDS YP_001852408.1 183984117 6228427 complement(5105284..5105841) 1 NC_010612.1 lipoprotein LprB 5105841 lprB 6228427 lprB Mycobacterium marinum M lipoprotein LprB YP_001852408.1 5105284 R 216594 CDS YP_001852409.1 183984118 6228428 5105989..5107728 1 NC_010612.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 5107728 6228428 MMAR_4147 Mycobacterium marinum M transmembrane ABC transporter ATP-binding protein YP_001852409.1 5105989 D 216594 CDS YP_001852410.1 183984119 6228429 5107725..5109647 1 NC_010612.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 5109647 6228429 MMAR_4148 Mycobacterium marinum M transmembrane ABC transporter ATP-binding protein YP_001852410.1 5107725 D 216594 CDS YP_001852411.1 183984120 6228430 complement(5109713..5111515) 1 NC_010612.1 PE-PGRS family protein 5111515 6228430 MMAR_4149 Mycobacterium marinum M PE-PGRS family protein YP_001852411.1 5109713 R 216594 CDS YP_001852412.1 183984121 6228431 5112236..5112568 1 NC_010612.1 hypothetical protein 5112568 6228431 MMAR_4150 Mycobacterium marinum M hypothetical protein YP_001852412.1 5112236 D 216594 CDS YP_001852413.1 183984122 6228432 5112800..5113132 1 NC_010612.1 hypothetical protein 5113132 6228432 MMAR_4151 Mycobacterium marinum M hypothetical protein YP_001852413.1 5112800 D 216594 CDS YP_001852414.1 183984123 6228433 5113372..5114112 1 NC_010612.1 lipoprotein LprA 5114112 lprA 6228433 lprA Mycobacterium marinum M lipoprotein LprA YP_001852414.1 5113372 D 216594 CDS YP_001852415.1 183984124 6228434 5114196..5114564 1 NC_010612.1 hypothetical protein 5114564 6228434 MMAR_4153 Mycobacterium marinum M hypothetical protein YP_001852415.1 5114196 D 216594 CDS YP_001852416.1 183984125 6228435 5114708..5115418 1 NC_010612.1 hypothetical protein 5115418 6228435 MMAR_4154 Mycobacterium marinum M hypothetical protein YP_001852416.1 5114708 D 216594 CDS YP_001852417.1 183984126 6228436 5115755..5116915 1 NC_010612.1 involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB; transcriptional regulatory protein EmbR 5116915 embR 6228436 embR Mycobacterium marinum M transcriptional regulatory protein EmbR YP_001852417.1 5115755 D 216594 CDS YP_001852418.1 183984127 6228437 5117268..5119058 1 NC_010612.1 involved in signal transduction (via phosphorylation). in M. tuberculosis thought to be involved in arabinan metabolism, phosphorylating perhaps EmbR [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 5119058 pknH 6228437 pknH Mycobacterium marinum M Ser/Thr protein kinase YP_001852418.1 5117268 D 216594 CDS YP_001852419.1 183984128 6228438 complement(5119449..5120351) 1 NC_010612.1 LuxR family transcriptional regulator 5120351 6228438 MMAR_4157 Mycobacterium marinum M LuxR family transcriptional regulator YP_001852419.1 5119449 R 216594 CDS YP_001852420.1 183984129 6228439 5120457..5121305 1 NC_010612.1 interconversion of acetate and oxaloacetate from citrate [catalytic activity: citrate = acetate + oxaloacetate]; citrate (pro-3S)-lyase subunit beta 5121305 citE_1 6228439 citE_1 Mycobacterium marinum M citrate (pro-3S)-lyase subunit beta YP_001852420.1 5120457 D 216594 CDS YP_001852421.1 183984130 6228440 5121293..5121820 1 NC_010612.1 dehydratase 5121820 6228440 MMAR_4159 Mycobacterium marinum M dehydratase YP_001852421.1 5121293 D 216594 CDS YP_001852422.1 183984131 6228441 5121820..5123157 1 NC_010612.1 could be implicated in several pathways involving acetyl-CoA. E.G. acetyl-CoA hydrolase from yeast catalyses the formation of acetate from acetyl-CoA, CoA transferase (CAT1) produces succinyl-CoA, and acetate-CoA transferase utilizes acyl-CoA and acetate to form acetyl-CoA; acetyl-CoA hydrolase/transferase 5123157 6228441 MMAR_4160 Mycobacterium marinum M acetyl-CoA hydrolase/transferase YP_001852422.1 5121820 D 216594 CDS YP_001852423.1 183984132 6228442 5123175..5124350 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE3 5124350 fadE3 6228442 fadE3 Mycobacterium marinum M acyl-CoA dehydrogenase FadE3 YP_001852423.1 5123175 D 216594 CDS YP_001852424.1 183984133 6228443 complement(5124382..5125290) 1 NC_010612.1 hydrolyses glycerophosphodiesters such as glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol, and bis(glycerophosphoglycerol); glycerolphosphodiesterase GdpD 5125290 gdpD 6228443 gdpD Mycobacterium marinum M glycerolphosphodiesterase GdpD YP_001852424.1 5124382 R 216594 CDS YP_001852425.1 183984134 6228444 complement(5125483..5125908) 1 NC_010612.1 hypothetical protein 5125908 6228444 MMAR_4163 Mycobacterium marinum M hypothetical protein YP_001852425.1 5125483 R 216594 CDS YP_001852426.1 183984135 6228445 5125980..5126612 1 NC_010612.1 hypothetical protein 5126612 6228445 MMAR_4164 Mycobacterium marinum M hypothetical protein YP_001852426.1 5125980 D 216594 CDS YP_001852427.1 183984136 6228446 complement(5126681..5127100) 1 NC_010612.1 glyoxalase I (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway; glyoxalase GloA 5127100 gloA_3 6228446 gloA_3 Mycobacterium marinum M glyoxalase GloA YP_001852427.1 5126681 R 216594 CDS YP_001852428.1 183984137 6228447 5128562..5129731 1 NC_010612.1 ESX-1 secretion-associated protein A, EspA 5129731 espA 6228447 espA Mycobacterium marinum M ESX-1 secretion-associated protein A, EspA YP_001852428.1 5128562 D 216594 CDS YP_001852429.1 183984138 6228448 5129792..5130103 1 NC_010612.1 hypothetical protein 5130103 6228448 MMAR_4167 Mycobacterium marinum M hypothetical protein YP_001852429.1 5129792 D 216594 CDS YP_001852430.1 183984139 6228449 5130117..5130788 1 NC_010612.1 hypothetical protein 5130788 6228449 MMAR_4168 Mycobacterium marinum M hypothetical protein YP_001852430.1 5130117 D 216594 CDS YP_001852431.1 183984140 6228450 5130970..5132823 1 NC_010612.1 involved in signal transduction (via phosphorylation) [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 5132823 pknH_1 6228450 pknH_1 Mycobacterium marinum M Ser/Thr protein kinase YP_001852431.1 5130970 D 216594 CDS YP_001852432.1 183984141 6228451 5132869..5135241 1 NC_010612.1 thought to be involved in active transport of undeterminated substrate (possibly lipooligosaccharide) across the membrane. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; transmembrane ABC transporter ATP-binding protein 5135241 6228451 MMAR_4170 Mycobacterium marinum M transmembrane ABC transporter ATP-binding protein YP_001852432.1 5132869 D 216594 CDS YP_001852433.1 183984142 6228452 5135676..5137679 1 NC_010612.1 involved in signal transduction (via phosphorylation). [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 5137679 6228452 MMAR_4171 Mycobacterium marinum M Ser/Thr protein kinase YP_001852433.1 5135676 D 216594 CDS YP_001852434.1 183984143 6228453 complement(5137691..5138278) 1 NC_010612.1 function unknown. seems to be expressed during macrophage infection; hypothetical protein 5138278 6228453 MMAR_4172 Mycobacterium marinum M hypothetical protein YP_001852434.1 5137691 R 216594 CDS YP_001852435.1 183984144 6228454 complement(5138569..5139750) 1 NC_010612.1 possibly involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]; adenylate cyclase 5139750 6228454 MMAR_4173 Mycobacterium marinum M adenylate cyclase YP_001852435.1 5138569 R 216594 CDS YP_001852436.1 183984145 6228455 5139850..5141337 1 NC_010612.1 involved in signal transduction (via phosphorylation). thought to be involved in membrane transport. phosphorylates the peptide substrate myelin basic protein (MBP) at serine and threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; anchored-membrane serine/threonine-protein kinase PknF 5141337 pknF 6228455 pknF Mycobacterium marinum M anchored-membrane serine/threonine-protein kinase PknF YP_001852436.1 5139850 D 216594 CDS YP_001852437.1 183984146 6228456 5141334..5141867 1 NC_010612.1 hypothetical protein 5141867 6228456 MMAR_4175 Mycobacterium marinum M hypothetical protein YP_001852437.1 5141334 D 216594 CDS YP_001852438.1 183984147 6228457 complement(5141881..5143269) 1 NC_010612.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 5143269 amiB2 6228457 amiB2 Mycobacterium marinum M amidase YP_001852438.1 5141881 R 216594 CDS YP_001852439.1 183984148 6228458 5143372..5143800 1 NC_010612.1 Hit-like protein 5143800 6228458 MMAR_4177 Mycobacterium marinum M Hit-like protein YP_001852439.1 5143372 D 216594 CDS YP_001852440.1 183984149 6228459 5143811..5144263 1 NC_010612.1 hypothetical protein 5144263 6228459 MMAR_4178 Mycobacterium marinum M hypothetical protein YP_001852440.1 5143811 D 216594 CDS YP_001852441.1 183984150 6228460 complement(5144272..5145315) 1 NC_010612.1 monooxygenase 5145315 6228460 MMAR_4179 Mycobacterium marinum M monooxygenase YP_001852441.1 5144272 R 216594 CDS YP_001852442.1 183984151 6228461 complement(5145362..5146498) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hypothetical protein 5146498 6228461 MMAR_4180 Mycobacterium marinum M hypothetical protein YP_001852442.1 5145362 R 216594 CDS YP_001852443.1 183984152 6228462 complement(5146502..5147329) 1 NC_010612.1 hypothetical protein 5147329 6228462 MMAR_4181 Mycobacterium marinum M hypothetical protein YP_001852443.1 5146502 R 216594 CDS YP_001852444.1 183984153 6228463 5147401..5148654 1 NC_010612.1 thought to be involved in transport of undeterminated substrate (possibly macrolide) across the membrane (export). responsible for the translocation of the undeterminated substrate across the membrane; hypothetical protein 5148654 6228463 MMAR_4182 Mycobacterium marinum M hypothetical protein YP_001852444.1 5147401 D 216594 CDS YP_001852445.1 183984154 6228464 5148712..5150079 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 5150079 6228464 MMAR_4183 Mycobacterium marinum M oxidoreductase YP_001852445.1 5148712 D 216594 CDS YP_001852446.1 183984155 6228465 5150285..5151526 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 130A4 Cyp130A4 5151526 cyp130A4 6228465 cyp130A4 Mycobacterium marinum M cytochrome P450 130A4 Cyp130A4 YP_001852446.1 5150285 D 216594 CDS YP_001852447.1 183984156 6228466 5151526..5152107 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 5152107 6228466 MMAR_4185 Mycobacterium marinum M transcriptional regulatory protein YP_001852447.1 5151526 D 216594 CDS YP_001852448.1 183984157 6228467 5152623..5154674 1 NC_010612.1 PE-PGRS family protein 5154674 6228467 MMAR_4186 Mycobacterium marinum M PE-PGRS family protein YP_001852448.1 5152623 D 216594 CDS YP_001852449.1 183984158 6228468 complement(5154828..5154980) 1 NC_010612.1 hypothetical protein 5154980 6228468 MMAR_5552 Mycobacterium marinum M hypothetical protein YP_001852449.1 5154828 R 216594 CDS YP_001852450.1 183984159 6228469 5155313..5156086 1 NC_010612.1 PPE family protein 5156086 6228469 MMAR_4187 Mycobacterium marinum M PPE family protein YP_001852450.1 5155313 D 216594 CDS YP_001852451.1 183984160 6228470 complement(5156177..5157319) 1 NC_010612.1 catalyzes the acylation of the mycaminose sugar during midecamycin biosynthesis; integral membrane acyltransferase 5157319 6228470 MMAR_4188 Mycobacterium marinum M integral membrane acyltransferase YP_001852451.1 5156177 R 216594 CDS YP_001852452.1 183984161 6228471 complement(5157316..5159031) 1 NC_010612.1 has a helix-destabilizing activity; cold-shock DEAD-box protein, DeaD 5159031 deaD 6228471 deaD Mycobacterium marinum M cold-shock DEAD-box protein, DeaD YP_001852452.1 5157316 R 216594 CDS YP_001852453.1 183984162 6228472 5159599..5160195 1 NC_010612.1 lipoprotein LprE 5160195 lprE 6228472 lprE Mycobacterium marinum M lipoprotein LprE YP_001852453.1 5159599 D 216594 CDS YP_001852454.1 183984163 6228473 5160269..5163685 1 NC_010612.1 hypothetical protein 5163685 6228473 MMAR_4191 Mycobacterium marinum M hypothetical protein YP_001852454.1 5160269 D 216594 CDS YP_001852455.1 183984164 6228474 complement(5163694..5165574) 1 NC_010612.1 thought to be involved in transport of drug across the membrane (export): drug resistance by an export mechanism (conferes resistance to toxic compounds by removing them for the cells). responsible for the translocation of the substrate across the membrane; drug-transport integral membrane protein 5165574 6228474 MMAR_4192 Mycobacterium marinum M drug-transport integral membrane protein YP_001852455.1 5163694 R 216594 CDS YP_001852456.1 183984165 6228475 5165787..5166545 1 NC_010612.1 hypothetical protein 5166545 6228475 MMAR_4193 Mycobacterium marinum M hypothetical protein YP_001852456.1 5165787 D 216594 CDS YP_001852457.1 183984166 6228476 5166708..5170463 1 NC_010612.1 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase 5170463 kgd 6228476 kgd Mycobacterium marinum M alpha-ketoglutarate decarboxylase YP_001852457.1 5166708 D 216594 CDS YP_001852458.1 183984167 6228477 5170620..5171453 1 NC_010612.1 function unknown, supposed involved in cellular metabolism; short-chain type dehydrogenase/reductase 5171453 6228477 MMAR_4195 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001852458.1 5170620 D 216594 CDS YP_001852459.1 183984168 6228478 complement(5171490..5172341) 1 NC_010612.1 lipoprotein LpqZ 5172341 lpqZ 6228478 lpqZ Mycobacterium marinum M lipoprotein LpqZ YP_001852459.1 5171490 R 216594 CDS YP_001852460.1 183984169 6228479 complement(5172353..5173567) 1 NC_010612.1 catalizes the oxidative decarboxylation of malate into pyruvate, important for a wide range of metabolic pathways [catalytic activity: (S)-malate + NAD(+) = pyruvate + CO(2) + NADH]; [NAD] dependent malate oxidoreductase Mez 5173567 mez_1 6228479 mez_1 Mycobacterium marinum M [NAD] dependent malate oxidoreductase Mez YP_001852460.1 5172353 R 216594 CDS YP_001852461.1 183984170 6228480 complement(5173726..5174715) 1 NC_010612.1 catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase 5174715 mdh 6228480 mdh Mycobacterium marinum M malate dehydrogenase YP_001852461.1 5173726 R 216594 CDS YP_001852462.1 183984171 6228481 5174899..5175999 1 NC_010612.1 thought to be involved in transport of magnesium and cobalt ions across the membrane. responsible for the translocation of the substrate across the membrane; magnesium and cobalt transport transmembrane protein CorA 5175999 corA 6228481 corA Mycobacterium marinum M magnesium and cobalt transport transmembrane protein CorA YP_001852462.1 5174899 D 216594 CDS YP_001852463.1 183984172 6228482 complement(5176004..5177149) 1 NC_010612.1 catalyzes oxidation of glucose-6-phosphate to 6- phosphogluconolactone using coenzyme F420 (an *-hydroxy-5- deazaflavin derivative) as the electron acceptor; F420-dependent glucose-6-phosphate dehydrogenase Fgd2 5177149 fgd2 6228482 fgd2 Mycobacterium marinum M F420-dependent glucose-6-phosphate dehydrogenase Fgd2 YP_001852463.1 5176004 R 216594 CDS YP_001852464.1 183984173 6228483 complement(5177391..5178836) 1 NC_010612.1 involved in 4-aminobutyrate (GabA) degradation pathway. transporter for GabA. responsible for the translocation of the substrate across the membrane; GabA permease GabP 5178836 gabP_1 6228483 gabP_1 Mycobacterium marinum M GabA permease GabP YP_001852464.1 5177391 R 216594 CDS YP_001852465.1 183984174 6228484 complement(5179118..5179711) 1 NC_010612.1 hypothetical protein 5179711 6228484 MMAR_4202 Mycobacterium marinum M hypothetical protein YP_001852465.1 5179118 R 216594 CDS YP_001852466.1 183984175 6228485 complement(5179708..5180895) 1 NC_010612.1 involved in active transport of sugar across the membrane (import). responsible for energy coupling to the transport system; sugar-transport ATP-binding protein ABC transporter SugC 5180895 sugC 6228485 sugC Mycobacterium marinum M sugar-transport ATP-binding protein ABC transporter SugC YP_001852466.1 5179708 R 216594 CDS YP_001852467.1 183984176 6228486 complement(5180900..5181730) 1 NC_010612.1 involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane; sugar-transport integral membrane protein ABC transporter SugB 5181730 sugB 6228486 sugB Mycobacterium marinum M sugar-transport integral membrane protein ABC transporter SugB YP_001852467.1 5180900 R 216594 CDS YP_001852468.1 183984177 6228487 complement(5181741..5182649) 1 NC_010612.1 involved in active transport of sugar across the membrane (import). responsible for the translocation of the substrate across the membrane; sugar-transport integral membrane protein ABC transporter SugA 5182649 sugA 6228487 sugA Mycobacterium marinum M sugar-transport integral membrane protein ABC transporter SugA YP_001852468.1 5181741 R 216594 CDS YP_001852469.1 183984178 6228488 complement(5182646..5184082) 1 NC_010612.1 thought to be involved in active transport of sugar across the membrane (import); sugar-binding lipoprotein LpqY 5184082 lpqY 6228488 lpqY Mycobacterium marinum M sugar-binding lipoprotein LpqY YP_001852469.1 5182646 R 216594 CDS YP_001852470.1 183984179 6228489 complement(5184093..5184620) 1 NC_010612.1 hypothetical protein 5184620 6228489 MMAR_4207 Mycobacterium marinum M hypothetical protein YP_001852470.1 5184093 R 216594 CDS YP_001852471.1 183984180 6228490 5184862..5185530 1 NC_010612.1 proline and glycine rich transmembrane protein 5185530 6228490 MMAR_4208 Mycobacterium marinum M proline and glycine rich transmembrane protein YP_001852471.1 5184862 D 216594 CDS YP_001852472.1 183984181 6228491 5185630..5186937 1 NC_010612.1 thought to be involved in Mg2+ transport. responsible for the translocation of the substrate across the membrane; transport transmembrane protein 5186937 6228491 MMAR_4209 Mycobacterium marinum M transport transmembrane protein YP_001852472.1 5185630 D 216594 CDS YP_001852473.1 183984182 6228492 5186934..5187464 1 NC_010612.1 hypothetical protein 5187464 6228492 MMAR_4210 Mycobacterium marinum M hypothetical protein YP_001852473.1 5186934 D 216594 CDS YP_001852474.1 183984183 6228493 5187583..5188956 1 NC_010612.1 membrane protein 5188956 6228493 MMAR_4211 Mycobacterium marinum M membrane protein YP_001852474.1 5187583 D 216594 CDS YP_001852475.1 183984184 6228494 5189008..5190168 1 NC_010612.1 function unknown: thought to be an ATP-binding protein; Mrp-related protein Mrp 5190168 mrp 6228494 mrp Mycobacterium marinum M Mrp-related protein Mrp YP_001852475.1 5189008 D 216594 CDS YP_001852476.1 183984185 6228495 complement(5190184..5190549) 1 NC_010612.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 5190549 tatB 6228495 tatB Mycobacterium marinum M sec-independent translocase YP_001852476.1 5190184 R 216594 CDS YP_001852477.1 183984186 6228496 complement(5190576..5192090) 1 NC_010612.1 possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residue); serine protease HtrA (DegP protein) 5192090 htrA 6228496 htrA Mycobacterium marinum M serine protease HtrA (DegP protein) YP_001852477.1 5190576 R 216594 CDS YP_001852478.1 183984187 6228497 complement(5192262..5192666) 1 NC_010612.1 hypothetical protein 5192666 6228497 MMAR_4215 Mycobacterium marinum M hypothetical protein YP_001852478.1 5192262 R 216594 CDS YP_001852479.1 183984188 6228498 complement(5192812..5193579) 1 NC_010612.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE 5193579 sigE 6228498 sigE Mycobacterium marinum M RNA polymerase sigma factor SigE YP_001852479.1 5192812 R 216594 CDS YP_001852480.1 183984189 6228499 5193802..5194476 1 NC_010612.1 function unknown, involved in cellular metabolism; methyltransferase 5194476 6228499 MMAR_4217 Mycobacterium marinum M methyltransferase YP_001852480.1 5193802 D 216594 CDS YP_001852481.1 183984190 6228500 complement(5194539..5196725) 1 NC_010612.1 PPE family protein 5196725 6228500 MMAR_4218 Mycobacterium marinum M PPE family protein YP_001852481.1 5194539 R 216594 CDS YP_001852482.1 183984191 6228501 5196932..5197570 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulator 5197570 6228501 MMAR_4219 Mycobacterium marinum M transcriptional regulator YP_001852482.1 5196932 D 216594 CDS YP_001852483.1 183984192 6228502 5197560..5198507 1 NC_010612.1 thought to be involved in active transport of antibiotic across the membrane (export): unidentified antibiotic resistance by an export mechanism. responsible for energy coupling to the transport system; antibiotic ABC transporter ATP-binding protein 5198507 6228502 MMAR_4220 Mycobacterium marinum M antibiotic ABC transporter ATP-binding protein YP_001852483.1 5197560 D 216594 CDS YP_001852484.1 183984193 6228503 5198504..5200147 1 NC_010612.1 thought to be involved in active transport of tetronasin across the membrane (export): tetronasin resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; tetronasin-transport integral membrane protein ABC transporter 5200147 6228503 MMAR_4221 Mycobacterium marinum M tetronasin-transport integral membrane protein ABC transporter YP_001852484.1 5198504 D 216594 CDS YP_001852485.1 183984194 6228504 5200176..5200850 1 NC_010612.1 integral membrane protein 5200850 6228504 MMAR_4222 Mycobacterium marinum M integral membrane protein YP_001852485.1 5200176 D 216594 CDS YP_001852486.1 183984195 6228505 5201063..5202871 1 NC_010612.1 PE-PGRS family protein 5202871 6228505 MMAR_4223 Mycobacterium marinum M PE-PGRS family protein YP_001852486.1 5201063 D 216594 CDS YP_001852487.1 183984196 6228506 5203115..5204911 1 NC_010612.1 PE-PGRS family protein 5204911 6228506 MMAR_4224 Mycobacterium marinum M PE-PGRS family protein YP_001852487.1 5203115 D 216594 CDS YP_001852488.1 183984197 6228507 complement(5205003..5206217) 1 NC_010612.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 5206217 glgC 6228507 glgC Mycobacterium marinum M glucose-1-phosphate adenylyltransferase YP_001852488.1 5205003 R 216594 CDS YP_001852489.1 183984198 6228508 5206427..5207590 1 NC_010612.1 function unknown; probably involved in cellular metabolism; glycosyl transferase family protein 5207590 6228508 MMAR_4226 Mycobacterium marinum M glycosyl transferase family protein YP_001852489.1 5206427 D 216594 CDS YP_001852490.1 183984199 6228509 complement(5207613..5207948) 1 NC_010612.1 hypothetical protein 5207948 6228509 MMAR_4227 Mycobacterium marinum M hypothetical protein YP_001852490.1 5207613 R 216594 CDS YP_001852491.1 183984200 6228510 complement(5207945..5208523) 1 NC_010612.1 involved in base excision repair. hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions; DNA-3-methyladenine glycosylase I TagA 5208523 tagA 6228510 tagA Mycobacterium marinum M DNA-3-methyladenine glycosylase I TagA YP_001852491.1 5207945 R 216594 CDS YP_001852492.1 183984201 6228511 complement(5208520..5208891) 1 NC_010612.1 hypothetical protein 5208891 6228511 MMAR_4229 Mycobacterium marinum M hypothetical protein YP_001852492.1 5208520 R 216594 CDS YP_001852493.1 183984202 6228512 complement(5208940..5209923) 1 NC_010612.1 putative glucosyl-3-phosphoglycerate synthase 5209923 6228512 MMAR_4230 Mycobacterium marinum M putative glucosyl-3-phosphoglycerate synthase YP_001852493.1 5208940 R 216594 CDS YP_001852494.1 183984203 6228513 complement(5209920..5210795) 1 NC_010612.1 involved in dihydrofolate biosynthesis [catalytic activity : 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate]; dihydropteroate synthase 2 FolP2 5210795 folP2 6228513 folP2 Mycobacterium marinum M dihydropteroate synthase 2 FolP2 YP_001852494.1 5209920 R 216594 CDS YP_001852495.1 183984204 6228514 complement(5210885..5212666) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization; long-chain-acyl-CoA synthetase 5212666 fadD6 6228514 fadD6 Mycobacterium marinum M long-chain-acyl-CoA synthetase YP_001852495.1 5210885 R 216594 CDS YP_001852496.1 183984205 6228515 complement(5212737..5213300) 1 NC_010612.1 hypothetical protein 5213300 6228515 MMAR_4233 Mycobacterium marinum M hypothetical protein YP_001852496.1 5212737 R 216594 CDS YP_001852497.1 183984206 6228516 5213388..5215532 1 NC_010612.1 hypothetical protein 5215532 6228516 MMAR_4234 Mycobacterium marinum M hypothetical protein YP_001852497.1 5213388 D 216594 CDS YP_001852498.1 183984207 6228517 complement(5215560..5216624) 1 NC_010612.1 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase 5216624 dapE 6228517 dapE Mycobacterium marinum M succinyl-diaminopimelate desuccinylase YP_001852498.1 5215560 R 216594 CDS YP_001852499.1 183984208 6228518 5216747..5217691 1 NC_010612.1 function unknown, probably involved in cellular metabolism; transferase 5217691 6228518 MMAR_4236 Mycobacterium marinum M transferase YP_001852499.1 5216747 D 216594 CDS YP_001852500.1 183984209 6228519 complement(5217746..5218246) 1 NC_010612.1 putative regulatory protein 5218246 6228519 MMAR_4237 Mycobacterium marinum M putative regulatory protein YP_001852500.1 5217746 R 216594 CDS YP_001852501.1 183984210 6228520 complement(5219131..5220414) 1 NC_010612.1 integral membrane transport protein 5220414 6228520 MMAR_4238 Mycobacterium marinum M integral membrane transport protein YP_001852501.1 5219131 R 216594 CDS YP_001852502.1 183984211 6228521 5221070..5221477 1 NC_010612.1 hypothetical protein 5221477 6228521 MMAR_4239 Mycobacterium marinum M hypothetical protein YP_001852502.1 5221070 D 216594 CDS YP_001852503.1 183984212 6228522 complement(5221634..5222815) 1 NC_010612.1 PPE family protein 5222815 6228522 MMAR_4240 Mycobacterium marinum M PPE family protein YP_001852503.1 5221634 R 216594 CDS YP_001852504.1 183984213 6228523 complement(5222855..5223154) 1 NC_010612.1 PPE family protein 5223154 6228523 MMAR_4241 Mycobacterium marinum M PPE family protein YP_001852504.1 5222855 R 216594 CDS YP_001852505.1 183984214 6228524 5223901..5225166 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 5225166 6228524 MMAR_4242 Mycobacterium marinum M transcriptional regulatory protein YP_001852505.1 5223901 D 216594 CDS YP_001852506.1 183984215 6228525 complement(5225169..5226587) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 5226587 fadD36 6228525 fadD36 Mycobacterium marinum M acyl-CoA synthetase YP_001852506.1 5225169 R 216594 CDS YP_001852507.1 183984216 6228526 complement(5226632..5227456) 1 NC_010612.1 hypothetical protein 5227456 6228526 MMAR_4244 Mycobacterium marinum M hypothetical protein YP_001852507.1 5226632 R 216594 CDS YP_001852508.1 183984217 6228527 complement(5227460..5228368) 1 NC_010612.1 hypothetical protein 5228368 6228527 MMAR_4245 Mycobacterium marinum M hypothetical protein YP_001852508.1 5227460 R 216594 CDS YP_001852509.1 183984218 6228528 complement(5228550..5230016) 1 NC_010612.1 oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; NAD-dependent aldehyde dehydrogenase AldA 5230016 aldA_1 6228528 aldA_1 Mycobacterium marinum M NAD-dependent aldehyde dehydrogenase AldA YP_001852509.1 5228550 R 216594 CDS YP_001852510.1 183984219 6228529 5230296..5230844 1 NC_010612.1 hypothetical protein 5230844 6228529 MMAR_4247 Mycobacterium marinum M hypothetical protein YP_001852510.1 5230296 D 216594 CDS YP_001852511.1 183984220 6228530 5230844..5231272 1 NC_010612.1 hypothetical protein 5231272 6228530 MMAR_4248 Mycobacterium marinum M hypothetical protein YP_001852511.1 5230844 D 216594 CDS YP_001852512.1 183984221 6228531 5231269..5231724 1 NC_010612.1 hypothetical protein 5231724 6228531 MMAR_4249 Mycobacterium marinum M hypothetical protein YP_001852512.1 5231269 D 216594 CDS YP_001852513.1 183984222 6228532 5231721..5232890 1 NC_010612.1 lipid-transfer protein 5232890 ltp2 6228532 ltp2 Mycobacterium marinum M lipid-transfer protein YP_001852513.1 5231721 D 216594 CDS YP_001852514.1 183984223 6228533 5232898..5233527 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulator 5233527 6228533 MMAR_4251 Mycobacterium marinum M transcriptional regulator YP_001852514.1 5232898 D 216594 CDS YP_001852515.1 183984224 6228534 complement(5233554..5234513) 1 NC_010612.1 oxidizes proline to glutamate for use as a carbon and nitrogen source [catalytic activity: L-proline + acceptor + H2O = (S)-1-pyrroline-5-carboxylate + reduced acceptor]; proline dehydrogenase, PutA 5234513 putA 6228534 putA Mycobacterium marinum M proline dehydrogenase, PutA YP_001852515.1 5233554 R 216594 CDS YP_001852516.1 183984225 6228535 complement(5234513..5236144) 1 NC_010612.1 involved in the arginase pathway [catalytic activity: 1-pyrroline-5-carboxylate + NAD(+) + H(2)O = L- glutamate + NADH]; pyrroline-5-carboxylate dehydrogenase, RocA 5236144 rocA 6228535 rocA Mycobacterium marinum M pyrroline-5-carboxylate dehydrogenase, RocA YP_001852516.1 5234513 R 216594 CDS YP_001852517.1 183984226 6228536 5236229..5237827 1 NC_010612.1 may be a regulatory protein; hypothetical protein 5237827 6228536 MMAR_4254 Mycobacterium marinum M hypothetical protein YP_001852517.1 5236229 D 216594 CDS YP_001852518.1 183984227 6228537 5237915..5238718 1 NC_010612.1 hypothetical protein 5238718 6228537 MMAR_4255 Mycobacterium marinum M hypothetical protein YP_001852518.1 5237915 D 216594 CDS YP_001852519.1 183984228 6228538 5238770..5238982 1 NC_010612.1 hypothetical protein 5238982 6228538 MMAR_4256 Mycobacterium marinum M hypothetical protein YP_001852519.1 5238770 D 216594 CDS YP_001852520.1 183984229 6228539 5239082..5239369 1 NC_010612.1 hypothetical protein 5239369 6228539 MMAR_5553 Mycobacterium marinum M hypothetical protein YP_001852520.1 5239082 D 216594 CDS YP_001852521.1 183984230 6228540 5239483..5240952 1 NC_010612.1 involved in secretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; nitrite extrusion protein, NarK3_3 5240952 narK3_3 6228540 narK3_3 Mycobacterium marinum M nitrite extrusion protein, NarK3_3 YP_001852521.1 5239483 D 216594 CDS YP_001852522.1 183984231 6228541 5241011..5241811 1 NC_010612.1 could help control the pool of 3'-PHOSPHOADENOSIDE 5'-phosphosulfate, or its use in sulfite synthesis (by similarity); monophosphatase CysQ-like protein 5241811 6228541 MMAR_4258 Mycobacterium marinum M monophosphatase CysQ-like protein YP_001852522.1 5241011 D 216594 CDS YP_001852523.1 183984232 6228542 5242294..5242998 1 NC_010612.1 ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity [catalytic activity 1: ATP + sulfate = diphosphate + adenylylsulfate] and APS kinase catalyzes the synthesis of activated sulfate [catalytic activity 2: ATP + adenylylsulfate = ADP + 3'- phosphoadenylylsulfate]. first and second steps in the sulfate activation pathway. these reactions occurs early in the reductive branch of the cysteine biosynthetic pathway; bifunctional enzyme CysN/CysC-like: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase 5242998 6228542 MMAR_4259 Mycobacterium marinum M bifunctional enzyme CysN/CysC-like: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase YP_001852523.1 5242294 D 216594 CDS YP_001852524.1 183984233 6228543 5243079..5244002 1 NC_010612.1 involved in sulfation: activity towards typical ceramide glycolipids and trehalose glycolipids; glycolipid sulfotransferase 5244002 6228543 MMAR_4260 Mycobacterium marinum M glycolipid sulfotransferase YP_001852524.1 5243079 D 216594 CDS YP_001852525.1 183984234 6228544 5243989..5245071 1 NC_010612.1 hypothetical protein 5245071 6228544 MMAR_4261 Mycobacterium marinum M hypothetical protein YP_001852525.1 5243989 D 216594 CDS YP_001852526.1 183984235 6228545 5245082..5246461 1 NC_010612.1 function unknown - possible Na+/H+ antiporter; hypothetical protein 5246461 6228545 MMAR_4262 Mycobacterium marinum M hypothetical protein YP_001852526.1 5245082 D 216594 CDS YP_001852527.1 183984236 6228546 5246555..5247820 1 NC_010612.1 ATP sulfurylase; ATPS; converts ATP and sulfate to 5'phosphosulfate and pyrophosphate; in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction; the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms; sulfate adenylyltransferase 5247820 sat 6228546 sat Mycobacterium marinum M sulfate adenylyltransferase YP_001852527.1 5246555 D 216594 CDS YP_001852528.1 183984237 6228547 5247817..5248128 1 NC_010612.1 hypothetical protein 5248128 6228547 MMAR_4264 Mycobacterium marinum M hypothetical protein YP_001852528.1 5247817 D 216594 CDS YP_001852529.1 183984238 6228548 complement(5248292..5249704) 1 NC_010612.1 involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; integral membrane nitrite extrusion protein NarK3_4 5249704 narK3_4 6228548 narK3_4 Mycobacterium marinum M integral membrane nitrite extrusion protein NarK3_4 YP_001852529.1 5248292 R 216594 CDS YP_001852530.1 183984239 6228549 complement(5250659..5252017) 1 NC_010612.1 PPE family protein 5252017 6228549 MMAR_4266 Mycobacterium marinum M PPE family protein YP_001852530.1 5250659 R 216594 CDS YP_001852531.1 183984240 6228550 complement(5252744..5253088) 1 NC_010612.1 involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. responsible for the translocation of the substrate across the membrane; integral membrane nitrite extrusion protein NarK3 5253088 narK3_1 6228550 narK3_1 Mycobacterium marinum M integral membrane nitrite extrusion protein NarK3 YP_001852531.1 5252744 R 216594 CDS YP_001852532.1 183984241 6228551 5253610..5254803 1 NC_010612.1 PPE family protein 5254803 6228551 MMAR_4268 Mycobacterium marinum M PPE family protein YP_001852532.1 5253610 D 216594 CDS YP_001852533.1 183984242 6228552 5254885..5256084 1 NC_010612.1 PPE family protein 5256084 6228552 MMAR_4269 Mycobacterium marinum M PPE family protein YP_001852533.1 5254885 D 216594 CDS YP_001852534.1 183984243 6228553 5256511..5258523 1 NC_010612.1 PE-PGRS family protein 5258523 6228553 MMAR_4270 Mycobacterium marinum M PE-PGRS family protein YP_001852534.1 5256511 D 216594 CDS YP_001852535.1 183984244 6228554 complement(5258558..5260069) 1 NC_010612.1 hypothetical protein 5260069 6228554 MMAR_4271 Mycobacterium marinum M hypothetical protein YP_001852535.1 5258558 R 216594 CDS YP_001852536.1 183984245 6228555 5260391..5263210 1 NC_010612.1 hypothetical protein 5263210 6228555 MMAR_4272 Mycobacterium marinum M hypothetical protein YP_001852536.1 5260391 D 216594 CDS YP_001852537.1 183984246 6228556 complement(5263274..5264371) 1 NC_010612.1 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase 5264371 6228556 MMAR_4273 Mycobacterium marinum M N-succinyldiaminopimelate aminotransferase YP_001852537.1 5263274 R 216594 CDS YP_001852538.1 183984247 6228557 complement(5264401..5264727) 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin FdxC 5264727 fdxC 6228557 fdxC Mycobacterium marinum M ferredoxin FdxC YP_001852538.1 5264401 R 216594 CDS YP_001852539.1 183984248 6228558 5264941..5265507 1 NC_010612.1 hypothetical protein 5265507 6228558 MMAR_4275 Mycobacterium marinum M hypothetical protein YP_001852539.1 5264941 D 216594 CDS YP_001852540.1 183984249 6228559 5265507..5267531 1 NC_010612.1 catalyzes the NADP-dependent reduction of 2,4- dienoyl-CoA to yield trans-2- enoyl-CoA [catalytic activity: TRANS-2,3-didehydroacyl-CoA + NADP(+) = trans, TRANS-2,3,4,5-tetradehydroacyl-CoA + NADPH]; NADPH dependent 2,4-dienoyl-CoA reductase FadH 5267531 fadH 6228559 fadH Mycobacterium marinum M NADPH dependent 2,4-dienoyl-CoA reductase FadH YP_001852540.1 5265507 D 216594 CDS YP_001852541.1 183984250 6228560 5267743..5268075 1 NC_010612.1 TB8.4; function unknown function (secreted protein); putative antigen 5268075 6228560 MMAR_4277 Mycobacterium marinum M putative antigen YP_001852541.1 5267743 D 216594 CDS YP_001852542.1 183984251 6228561 complement(5268285..5270984) 1 NC_010612.1 PE-PGRS family protein 5270984 6228561 MMAR_4278 Mycobacterium marinum M PE-PGRS family protein YP_001852542.1 5268285 R 216594 CDS YP_001852543.1 183984252 6228562 complement(5271556..5274126) 1 NC_010612.1 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; FO synthase 5274126 fbiC 6228562 fbiC Mycobacterium marinum M FO synthase YP_001852543.1 5271556 R 216594 CDS YP_001852544.1 183984253 6228563 5274331..5275197 1 NC_010612.1 PE family protein 5275197 6228563 MMAR_4280 Mycobacterium marinum M PE family protein YP_001852544.1 5274331 D 216594 CDS YP_001852545.1 183984254 6228564 complement(5275227..5275586) 1 NC_010612.1 function unknown -possibly a transmembrane protein; hypothetical protein 5275586 6228564 MMAR_4281 Mycobacterium marinum M hypothetical protein YP_001852545.1 5275227 R 216594 CDS YP_001852546.1 183984255 6228565 complement(5275797..5276702) 1 NC_010612.1 involved in mycothiol biosynthesis. 1-D-myo- inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins)is converted to 1-D-myo-inosityl-2-amino-2- deoxy-alpha-D-glucopyranoside (GlcN-Ins) by this enzyme. seems to possesse weak mycothiol conjugate ami; N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB 5276702 mshB 6228565 mshB Mycobacterium marinum M N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB YP_001852546.1 5275797 R 216594 CDS YP_001852547.1 183984256 6228566 5276876..5277499 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 5277499 6228566 MMAR_4284 Mycobacterium marinum M transcriptional regulatory protein YP_001852547.1 5276876 D 216594 CDS YP_001852548.1 183984257 6228568 complement(5278846..5281047) 1 NC_010612.1 PE-PGRS family protein 5281047 6228568 MMAR_4287 Mycobacterium marinum M PE-PGRS family protein YP_001852548.1 5278846 R 216594 CDS YP_001852549.1 183984258 6228569 complement(5281258..5283165) 1 NC_010612.1 lipoprotein LpqW 5283165 lpqW 6228569 lpqW Mycobacterium marinum M lipoprotein LpqW YP_001852549.1 5281258 R 216594 CDS YP_001852550.1 183984259 6228570 complement(5283263..5285149) 1 NC_010612.1 function unknown, probably interacts with the ribosomes in a GTP dependent manner; GTP-binding translation elongation factor TypA 5285149 typA 6228570 typA Mycobacterium marinum M GTP-binding translation elongation factor TypA YP_001852550.1 5283263 R 216594 CDS YP_001852551.1 183984260 6228571 complement(5285401..5285991) 1 NC_010612.1 involved in the go system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool. 8-OXO-dGTP is inserted opposite da and dc residues of template DNA with almost equal efficiency thus leading to at to Gc transversions. mutt specifically degrades 8-OXO-dGTP to the monophosphate; mutator protein MutT2 5285991 mutT2 6228571 mutT2 Mycobacterium marinum M mutator protein MutT2 YP_001852551.1 5285401 R 216594 CDS YP_001852552.1 183984261 6228572 5286050..5286361 1 NC_010612.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase 5286361 phhB 6228572 phhB Mycobacterium marinum M pterin-4-alpha-carbinolamine dehydratase YP_001852552.1 5286050 D 216594 CDS YP_001852553.1 183984262 6228573 complement(5286387..5287655) 1 NC_010612.1 involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis; mannosyltransferase 5287655 pimE 6228573 pimE Mycobacterium marinum M mannosyltransferase YP_001852553.1 5286387 R 216594 CDS YP_001852554.1 183984263 6228574 5287797..5288423 1 NC_010612.1 hypothetical protein 5288423 6228574 MMAR_4293 Mycobacterium marinum M hypothetical protein YP_001852554.1 5287797 D 216594 CDS YP_001852555.1 183984264 6228575 5288473..5289672 1 NC_010612.1 hypothetical protein 5289672 6228575 MMAR_4294 Mycobacterium marinum M hypothetical protein YP_001852555.1 5288473 D 216594 CDS YP_001852556.1 183984265 6228576 complement(5289704..5289850) 1 NC_010612.1 hypothetical protein 5289850 6228576 MMAR_4295 Mycobacterium marinum M hypothetical protein YP_001852556.1 5289704 R 216594 CDS YP_001852557.1 183984266 6228577 complement(5289875..5290453) 1 NC_010612.1 hypothetical protein 5290453 6228577 MMAR_4296 Mycobacterium marinum M hypothetical protein YP_001852557.1 5289875 R 216594 CDS YP_001852558.1 183984267 6228578 complement(5290527..5290715) 1 NC_010612.1 hypothetical protein 5290715 6228578 MMAR_4297 Mycobacterium marinum M hypothetical protein YP_001852558.1 5290527 R 216594 CDS YP_001852559.1 183984268 6228579 complement(5290738..5291181) 1 NC_010612.1 hypothetical protein 5291181 6228579 MMAR_4298 Mycobacterium marinum M hypothetical protein YP_001852559.1 5290738 R 216594 CDS YP_001852560.1 183984269 6228580 5291238..5291753 1 NC_010612.1 hypothetical protein 5291753 6228580 MMAR_4299 Mycobacterium marinum M hypothetical protein YP_001852560.1 5291238 D 216594 CDS YP_001852561.1 183984270 6228581 5291768..5292604 1 NC_010612.1 function unknown, but supposed involved in lipid metabolism; O-methyltransferase Omt_2 5292604 omt_2 6228581 omt_2 Mycobacterium marinum M O-methyltransferase Omt_2 YP_001852561.1 5291768 D 216594 CDS YP_001852562.1 183984271 6228582 complement(5292614..5292979) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 5292979 6228582 MMAR_4301 Mycobacterium marinum M transcriptional regulatory protein YP_001852562.1 5292614 R 216594 CDS YP_001852563.1 183984272 6228583 5293038..5293754 1 NC_010612.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 5293754 6228583 MMAR_4302 Mycobacterium marinum M NAD-dependent deacetylase YP_001852563.1 5293038 D 216594 CDS YP_001852564.1 183984273 6228584 complement(5293862..5294500) 1 NC_010612.1 hypothetical protein 5294500 6228584 MMAR_4303 Mycobacterium marinum M hypothetical protein YP_001852564.1 5293862 R 216594 CDS YP_001852565.1 183984274 6228585 complement(5294497..5295195) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 5295195 6228585 MMAR_4304 Mycobacterium marinum M TetR family transcriptional regulator YP_001852565.1 5294497 R 216594 CDS YP_001852566.1 183984275 6228586 complement(5295197..5297539) 1 NC_010612.1 function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL13 5297539 mmpL13 6228586 mmpL13 Mycobacterium marinum M transmembrane transport protein MmpL13 YP_001852566.1 5295197 R 216594 CDS YP_001852567.1 183984276 6228587 5297897..5298052 1 NC_010612.1 hypothetical protein 5298052 6228587 MMAR_4306 Mycobacterium marinum M hypothetical protein YP_001852567.1 5297897 D 216594 CDS YP_001852568.1 183984277 6228588 complement(5298189..5298950) 1 NC_010612.1 function unknown, supposed involved in cellular metabolism; short-chain type dehydrogenase/reductase 5298950 6228588 MMAR_4307 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001852568.1 5298189 R 216594 CDS YP_001852569.1 183984278 6228589 complement(5299008..5300105) 1 NC_010612.1 required for bile acid synthesis and for catabolism of branched-chain fatty acids; alpha-methylacyl-CoA racemase Mcr 5300105 mcr 6228589 mcr Mycobacterium marinum M alpha-methylacyl-CoA racemase Mcr YP_001852569.1 5299008 R 216594 CDS YP_001852570.1 183984279 6228590 5300259..5301062 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 5301062 echA10 6228590 echA10 Mycobacterium marinum M enoyl-CoA hydratase YP_001852570.1 5300259 D 216594 CDS YP_001852571.1 183984280 6228591 5301135..5302526 1 NC_010612.1 oxidoreductase 5302526 6228591 MMAR_4310 Mycobacterium marinum M oxidoreductase YP_001852571.1 5301135 D 216594 CDS YP_001852572.1 183984281 6228592 complement(5302532..5303251) 1 NC_010612.1 integral membrane protein 5303251 6228592 MMAR_4311 Mycobacterium marinum M integral membrane protein YP_001852572.1 5302532 R 216594 CDS YP_001852573.1 183984282 6228593 complement(5303248..5304396) 1 NC_010612.1 hypothetical protein 5304396 6228593 MMAR_4312 Mycobacterium marinum M hypothetical protein YP_001852573.1 5303248 R 216594 CDS YP_001852574.1 183984283 6228594 5304583..5305632 1 NC_010612.1 ortholog of pks10; possibly involved in the biosynthesis of secondary metabolites [catalytic activity: 3 malonyl-CoA + 4- coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2]; chalcone synthase 5305632 6228594 MMAR_4313 Mycobacterium marinum M chalcone synthase YP_001852574.1 5304583 D 216594 CDS YP_001852575.1 183984284 6228595 5305626..5306135 1 NC_010612.1 hypothetical protein 5306135 6228595 MMAR_4314 Mycobacterium marinum M hypothetical protein YP_001852575.1 5305626 D 216594 CDS YP_001852576.1 183984285 6228596 5306132..5307148 1 NC_010612.1 function unknown; probably involved in cellular metabolism; oxidoreductase 5307148 6228596 MMAR_4315 Mycobacterium marinum M oxidoreductase YP_001852576.1 5306132 D 216594 CDS YP_001852577.1 183984286 6228597 complement(5307272..5313196) 1 NC_010612.1 PE-PGRS family protein 5313196 6228597 MMAR_4316 Mycobacterium marinum M PE-PGRS family protein YP_001852577.1 5307272 R 216594 CDS YP_001852578.1 183984287 6228598 complement(5313624..5314427) 1 NC_010612.1 oxidize fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA1 5314427 echA1_1 6228598 echA1_1 Mycobacterium marinum M enoyl-CoA hydratase, EchA1 YP_001852578.1 5313624 R 216594 CDS YP_001852579.1 183984288 6228599 complement(5314424..5315572) 1 NC_010612.1 function unknown, but involved in lipid degradation [catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl- CoA]; acetyl-CoA acetyltransferase 5315572 fadA6_3 6228599 fadA6_3 Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001852579.1 5314424 R 216594 CDS YP_001852580.1 183984289 6228600 5316112..5317977 1 NC_010612.1 PPE family protein 5317977 6228600 MMAR_4319 Mycobacterium marinum M PPE family protein YP_001852580.1 5316112 D 216594 CDS YP_001852581.1 183984290 6228601 5318444..5321764 1 NC_010612.1 PPE family protein 5321764 6228601 MMAR_4320 Mycobacterium marinum M PPE family protein YP_001852581.1 5318444 D 216594 CDS YP_001852582.1 183984291 6228602 complement(5321829..5323595) 1 NC_010612.1 PE family protein 5323595 6228602 MMAR_4321 Mycobacterium marinum M PE family protein YP_001852582.1 5321829 R 216594 CDS YP_001852583.1 183984292 6228603 complement(5324094..5325587) 1 NC_010612.1 oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; NAD dependent aldehyde dehydrogenase 5325587 aldA_2 6228603 aldA_2 Mycobacterium marinum M NAD dependent aldehyde dehydrogenase YP_001852583.1 5324094 R 216594 CDS YP_001852584.1 183984293 6228604 complement(5326176..5327018) 1 NC_010612.1 single copy element; transposition of an IS110 family element; transposase 5327018 6228604 MMAR_4323 Mycobacterium marinum M transposase YP_001852584.1 5326176 R 216594 CDS YP_001852585.1 183984294 6228605 5327429..5327668 1 NC_010612.1 hypothetical protein 5327668 6228605 MMAR_5543 Mycobacterium marinum M hypothetical protein YP_001852585.1 5327429 D 216594 CDS YP_001852586.1 183984295 6228606 complement(5328392..5329561) 1 NC_010612.1 PPE family protein 5329561 6228606 MMAR_4324 Mycobacterium marinum M PPE family protein YP_001852586.1 5328392 R 216594 CDS YP_001852587.1 183984296 6228607 5330081..5331355 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 5331355 6228607 MMAR_4325 Mycobacterium marinum M TetR family transcriptional regulator YP_001852587.1 5330081 D 216594 CDS YP_001852588.1 183984297 6228608 5331460..5332302 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 5332302 6228608 MMAR_4326 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001852588.1 5331460 D 216594 CDS YP_001852589.1 183984298 6228609 5332319..5332969 1 NC_010612.1 function unknown, contains NADH-flavin reductase domain; hypothetical protein 5332969 6228609 MMAR_4327 Mycobacterium marinum M hypothetical protein YP_001852589.1 5332319 D 216594 CDS YP_001852590.1 183984299 6228610 5333386..5335677 1 NC_010612.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 5335677 metE 6228610 metE Mycobacterium marinum M 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase YP_001852590.1 5333386 D 216594 CDS YP_001852591.1 183984300 6228611 complement(5335755..5337488) 1 NC_010612.1 hypothetical protein 5337488 6228611 MMAR_4329 Mycobacterium marinum M hypothetical protein YP_001852591.1 5335755 R 216594 CDS YP_001852592.1 183984301 6228612 complement(5337548..5338057) 1 NC_010612.1 hypothetical protein 5338057 6228612 MMAR_4330 Mycobacterium marinum M hypothetical protein YP_001852592.1 5337548 R 216594 CDS YP_001852593.1 183984302 6228613 5338125..5339795 1 NC_010612.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 5339795 ppdK 6228613 ppdK Mycobacterium marinum M pyruvate phosphate dikinase YP_001852593.1 5338125 D 216594 CDS YP_001852594.1 183984303 6228614 5339792..5340397 1 NC_010612.1 hypothetical protein 5340397 6228614 MMAR_4332 Mycobacterium marinum M hypothetical protein YP_001852594.1 5339792 D 216594 CDS YP_001852595.1 183984304 6228615 complement(5340404..5341645) 1 NC_010612.1 hypothetical protein 5341645 6228615 MMAR_4333 Mycobacterium marinum M hypothetical protein YP_001852595.1 5340404 R 216594 CDS YP_001852596.1 183984305 6228616 complement(5341650..5342555) 1 NC_010612.1 thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol]; epoxide hydrolase EphC 5342555 ephC 6228616 ephC Mycobacterium marinum M epoxide hydrolase EphC YP_001852596.1 5341650 R 216594 CDS YP_001852597.1 183984306 6228617 5343109..5343696 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 5343696 6228617 MMAR_4335 Mycobacterium marinum M TetR family transcriptional regulator YP_001852597.1 5343109 D 216594 CDS YP_001852598.1 183984307 6228618 complement(5343699..5344175) 1 NC_010612.1 hypothetical protein 5344175 6228618 MMAR_4336 Mycobacterium marinum M hypothetical protein YP_001852598.1 5343699 R 216594 CDS YP_001852599.1 183984308 6228619 5344302..5345177 1 NC_010612.1 supposed involved in detoxification reactions; peroxidase BpoB 5345177 bpoB 6228619 bpoB Mycobacterium marinum M peroxidase BpoB YP_001852599.1 5344302 D 216594 CDS YP_001852600.1 183984309 6228620 complement(5345174..5346196) 1 NC_010612.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; 6-phosphogluconate dehydrogenase 5346196 gnd2 6228620 gnd2 Mycobacterium marinum M 6-phosphogluconate dehydrogenase YP_001852600.1 5345174 R 216594 CDS YP_001852601.1 183984310 6228621 complement(5346211..5347620) 1 NC_010612.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 5347620 zwf1 6228621 zwf1 Mycobacterium marinum M glucose-6-phosphate 1-dehydrogenase YP_001852601.1 5346211 R 216594 CDS YP_001852602.1 183984311 6228622 5347775..5348599 1 NC_010612.1 hypothetical protein 5348599 6228622 MMAR_4340 Mycobacterium marinum M hypothetical protein YP_001852602.1 5347775 D 216594 CDS YP_001852603.1 183984312 6228623 5348632..5348811 1 NC_010612.1 hypothetical protein 5348811 6228623 MMAR_4341 Mycobacterium marinum M hypothetical protein YP_001852603.1 5348632 D 216594 CDS YP_001852604.1 183984313 6228624 5348793..5349494 1 NC_010612.1 hypothetical protein 5349494 6228624 MMAR_4342 Mycobacterium marinum M hypothetical protein YP_001852604.1 5348793 D 216594 CDS YP_001852605.1 183984314 6228625 complement(5349591..5349920) 1 NC_010612.1 hypothetical protein 5349920 6228625 MMAR_4343 Mycobacterium marinum M hypothetical protein YP_001852605.1 5349591 R 216594 CDS YP_001852606.1 183984315 6228626 complement(5349996..5350514) 1 NC_010612.1 hypothetical protein 5350514 6228626 MMAR_4344 Mycobacterium marinum M hypothetical protein YP_001852606.1 5349996 R 216594 CDS YP_001852607.1 183984316 6228627 complement(5350829..5351389) 1 NC_010612.1 hypothetical protein 5351389 6228627 MMAR_4345 Mycobacterium marinum M hypothetical protein YP_001852607.1 5350829 R 216594 CDS YP_001852608.1 183984317 6228628 complement(5351761..5352753) 1 NC_010612.1 PPE family protein 5352753 6228628 MMAR_4346 Mycobacterium marinum M PPE family protein YP_001852608.1 5351761 R 216594 CDS YP_001852609.1 183984318 6228629 5353161..5354540 1 NC_010612.1 hypothetical protein 5354540 6228629 MMAR_4347 Mycobacterium marinum M hypothetical protein YP_001852609.1 5353161 D 216594 CDS YP_001852610.1 183984319 6228630 5354543..5354881 1 NC_010612.1 hypothetical protein 5354881 6228630 MMAR_4348 Mycobacterium marinum M hypothetical protein YP_001852610.1 5354543 D 216594 CDS YP_001852611.1 183984320 6228631 5354958..5355272 1 NC_010612.1 hypothetical protein 5355272 6228631 MMAR_4349 Mycobacterium marinum M hypothetical protein YP_001852611.1 5354958 D 216594 CDS YP_001852612.1 183984321 6228632 5355391..5355990 1 NC_010612.1 hypothetical protein 5355990 6228632 MMAR_4350 Mycobacterium marinum M hypothetical protein YP_001852612.1 5355391 D 216594 CDS YP_001852613.1 183984322 6228633 5355965..5357995 1 NC_010612.1 hypothetical protein 5357995 6228633 MMAR_4351 Mycobacterium marinum M hypothetical protein YP_001852613.1 5355965 D 216594 CDS YP_001852614.1 183984323 6228634 complement(5358011..5358793) 1 NC_010612.1 hypothetical protein 5358793 6228634 MMAR_4352 Mycobacterium marinum M hypothetical protein YP_001852614.1 5358011 R 216594 CDS YP_001852615.1 183984324 6228635 complement(5359248..5360348) 1 NC_010612.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 5360348 6228635 MMAR_4353 Mycobacterium marinum M GTP-dependent nucleic acid-binding protein EngD YP_001852615.1 5359248 R 216594 CDS YP_001852616.1 183984325 6228636 5360481..5361698 1 NC_010612.1 hypothetical protein 5361698 6228636 MMAR_4354 Mycobacterium marinum M hypothetical protein YP_001852616.1 5360481 D 216594 CDS YP_001852617.1 183984326 6228637 complement(5361720..5362718) 1 NC_010612.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 5362718 ispH 6228637 ispH Mycobacterium marinum M 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_001852617.1 5361720 R 216594 CDS YP_001852618.1 183984327 6228638 5362828..5363445 1 NC_010612.1 hypothetical protein 5363445 6228638 MMAR_4356 Mycobacterium marinum M hypothetical protein YP_001852618.1 5362828 D 216594 CDS YP_001852619.1 183984328 6228639 5363442..5364689 1 NC_010612.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 5364689 xseA 6228639 xseA Mycobacterium marinum M exodeoxyribonuclease VII large subunit YP_001852619.1 5363442 D 216594 CDS YP_001852620.1 183984329 6228640 5364679..5364927 1 NC_010612.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 5364927 xseB 6228640 xseB Mycobacterium marinum M exodeoxyribonuclease VII small subunit YP_001852620.1 5364679 D 216594 CDS YP_001852621.1 183984330 6228641 5364982..5366076 1 NC_010612.1 function unknown, probably involved in cellular metabolism; cholesterol dehydrogenase 5366076 6228641 MMAR_4359 Mycobacterium marinum M cholesterol dehydrogenase YP_001852621.1 5364982 D 216594 CDS YP_001852622.1 183984331 6228642 5366256..5366513 1 NC_010612.1 hypothetical protein 5366513 6228642 MMAR_4360 Mycobacterium marinum M hypothetical protein YP_001852622.1 5366256 D 216594 CDS YP_001852623.1 183984332 6228643 complement(5366608..5367009) 1 NC_010612.1 hypothetical protein 5367009 6228643 MMAR_4361 Mycobacterium marinum M hypothetical protein YP_001852623.1 5366608 R 216594 CDS YP_001852624.1 183984333 6228644 5367700..5369265 1 NC_010612.1 PE-PGRS family protein 5369265 6228644 MMAR_4362 Mycobacterium marinum M PE-PGRS family protein YP_001852624.1 5367700 D 216594 CDS YP_001852625.1 183984334 6228645 complement(5369535..5371124) 1 NC_010612.1 function unknown; possible carboxylesterase type B (lipid metabolism) domain; carboxylesterase 5371124 6228645 MMAR_4363 Mycobacterium marinum M carboxylesterase YP_001852625.1 5369535 R 216594 CDS YP_001852626.1 183984335 6228646 5371313..5372470 1 NC_010612.1 hypothetical protein 5372470 6228646 MMAR_4364 Mycobacterium marinum M hypothetical protein YP_001852626.1 5371313 D 216594 CDS YP_001852627.1 183984336 6228647 complement(5372448..5373248) 1 NC_010612.1 hypothetical protein 5373248 6228647 MMAR_4365 Mycobacterium marinum M hypothetical protein YP_001852627.1 5372448 R 216594 CDS YP_001852628.1 183984337 6228648 complement(5373276..5373923) 1 NC_010612.1 hypothetical protein 5373923 6228648 MMAR_4366 Mycobacterium marinum M hypothetical protein YP_001852628.1 5373276 R 216594 CDS YP_001852629.1 183984338 6228649 5373992..5375080 1 NC_010612.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 5375080 glpX 6228649 glpX Mycobacterium marinum M fructose 1,6-bisphosphatase II YP_001852629.1 5373992 D 216594 CDS YP_001852630.1 183984339 6228650 5375118..5376548 1 NC_010612.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 5376548 fumC 6228650 fumC Mycobacterium marinum M fumarate hydratase YP_001852630.1 5375118 D 216594 CDS YP_001852631.1 183984340 6228651 5376645..5377625 1 NC_010612.1 membrane glycine and proline rich protein 5377625 6228651 MMAR_4369 Mycobacterium marinum M membrane glycine and proline rich protein YP_001852631.1 5376645 D 216594 CDS YP_001852632.1 183984341 6228652 complement(5377655..5379163) 1 NC_010612.1 hypothetical protein 5379163 6228652 MMAR_4370 Mycobacterium marinum M hypothetical protein YP_001852632.1 5377655 R 216594 CDS YP_001852633.1 183984342 6228653 complement(5379156..5380031) 1 NC_010612.1 probably involved in carbohydrate degradation. may hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non- carbohydrate moiety; glycosyl hydrolase 5380031 6228653 MMAR_4371 Mycobacterium marinum M glycosyl hydrolase YP_001852633.1 5379156 R 216594 CDS YP_001852634.1 183984343 6228654 complement(5380103..5381404) 1 NC_010612.1 PhoH-like protein PhoH2 5381404 phoH2 6228654 phoH2 Mycobacterium marinum M PhoH-like protein PhoH2 YP_001852634.1 5380103 R 216594 CDS YP_001852635.1 183984344 6228655 complement(5381401..5381700) 1 NC_010612.1 hypothetical protein 5381700 6228655 MMAR_4373 Mycobacterium marinum M hypothetical protein YP_001852635.1 5381401 R 216594 CDS YP_001852636.1 183984345 6228656 complement(5381719..5382546) 1 NC_010612.1 thought to catalyze the principal conversion of saturated fatty acids to unsaturated fatty acids. thought to convert stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons delta-9 and delta-10 of the acyl chain [catalytic activity: stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + a + 2 H2O]; acyl-[acyl-carrier protein] desaturase DesA2 5382546 desA2 6228656 desA2 Mycobacterium marinum M acyl-[acyl-carrier protein] desaturase DesA2 YP_001852636.1 5381719 R 216594 CDS YP_001852637.1 183984346 6228657 complement(5382603..5383883) 1 NC_010612.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 5383883 glyA 6228657 glyA Mycobacterium marinum M serine hydroxymethyltransferase YP_001852637.1 5382603 R 216594 CDS YP_001852638.1 183984347 6228658 5384045..5384983 1 NC_010612.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 5384983 coaA 6228658 coaA Mycobacterium marinum M pantothenate kinase YP_001852638.1 5384045 D 216594 CDS YP_001852639.1 183984348 6228659 complement(5385034..5386563) 1 NC_010612.1 PE-PGRS family protein 5386563 6228659 MMAR_4377 Mycobacterium marinum M PE-PGRS family protein YP_001852639.1 5385034 R 216594 CDS YP_001852640.1 183984349 6228660 complement(5386769..5387182) 1 NC_010612.1 hypothetical protein 5387182 6228660 MMAR_4378 Mycobacterium marinum M hypothetical protein YP_001852640.1 5386769 R 216594 CDS YP_001852641.1 183984350 6228661 complement(5387372..5388742) 1 NC_010612.1 hypothetical protein 5388742 6228661 MMAR_4379 Mycobacterium marinum M hypothetical protein YP_001852641.1 5387372 R 216594 CDS YP_001852642.1 183984351 6228662 complement(5388981..5389769) 1 NC_010612.1 catalyzes the first committed step in the synthesis of decaprenyl diphosphate, a molecule which has a central role in the biosynthesis of most features of the mycobacterial cell wall. adds one isoprene unit to omega,E- geranyl diphosphate. in mycobacterium; short (C15) chain Z-isoprenyl diphosphate synthase, UppS 5389769 uppS 6228662 uppS Mycobacterium marinum M short (C15) chain Z-isoprenyl diphosphate synthase, UppS YP_001852642.1 5388981 R 216594 CDS YP_001852643.1 183984352 6228663 5389916..5390656 1 NC_010612.1 potential role involved in virulence; hemolysin-like protein 5390656 6228663 MMAR_4381 Mycobacterium marinum M hemolysin-like protein YP_001852643.1 5389916 D 216594 CDS YP_001852644.1 183984353 6228664 complement(5390681..5391064) 1 NC_010612.1 hypothetical protein 5391064 6228664 MMAR_4382 Mycobacterium marinum M hypothetical protein YP_001852644.1 5390681 R 216594 CDS YP_001852645.1 183984354 6228665 complement(5391078..5393102) 1 NC_010612.1 transmembrane protein 5393102 6228665 MMAR_4383 Mycobacterium marinum M transmembrane protein YP_001852645.1 5391078 R 216594 CDS YP_001852646.1 183984355 6228666 complement(5393089..5393388) 1 NC_010612.1 hypothetical protein 5393388 6228666 MMAR_4384 Mycobacterium marinum M hypothetical protein YP_001852646.1 5393089 R 216594 CDS YP_001852647.1 183984356 6228667 complement(5393385..5394257) 1 NC_010612.1 mycothiol-dependent detoxification enzyme, involved in mycothiol biosynthesis; mycothiol conjugate amidase Mca 5394257 mca 6228667 mca Mycobacterium marinum M mycothiol conjugate amidase Mca YP_001852647.1 5393385 R 216594 CDS YP_001852648.1 183984357 6228668 5394399..5394833 1 NC_010612.1 hypothetical protein 5394833 6228668 MMAR_4386 Mycobacterium marinum M hypothetical protein YP_001852648.1 5394399 D 216594 CDS YP_001852649.1 183984358 6228669 5395065..5395559 1 NC_010612.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 5395559 greA 6228669 greA Mycobacterium marinum M transcription elongation factor GreA YP_001852649.1 5395065 D 216594 CDS YP_001852650.1 183984359 6228670 complement(5395642..5396808) 1 NC_010612.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 5396808 metB 6228670 metB Mycobacterium marinum M cystathionine gamma-synthase YP_001852650.1 5395642 R 216594 CDS YP_001852651.1 183984360 6228671 complement(5396908..5397711) 1 NC_010612.1 proline-rich antigen, Pra 5397711 pra 6228671 pra Mycobacterium marinum M proline-rich antigen, Pra YP_001852651.1 5396908 R 216594 CDS YP_001852652.1 183984361 6228672 complement(5397907..5399301) 1 NC_010612.1 thought to be involved in homocysteine transulfuration [catalytic activity: L-serine + L- homocysteine = cystathionine + H2O]; cystathionine beta-synthase 5399301 cbs 6228672 cbs Mycobacterium marinum M cystathionine beta-synthase YP_001852652.1 5397907 R 216594 CDS YP_001852653.1 183984362 6228673 complement(5399360..5400427) 1 NC_010612.1 hydrolyses lipids; lipase LipU 5400427 lipU 6228673 lipU Mycobacterium marinum M lipase LipU YP_001852653.1 5399360 R 216594 CDS YP_001852654.1 183984363 6228674 5400673..5401632 1 NC_010612.1 hypothetical protein 5401632 6228674 MMAR_4392 Mycobacterium marinum M hypothetical protein YP_001852654.1 5400673 D 216594 CDS YP_001852655.1 183984364 6228675 5401710..5402942 1 NC_010612.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 5402942 fadA3 6228675 fadA3 Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001852655.1 5401710 D 216594 CDS YP_001852656.1 183984365 6228676 complement(5403121..5403963) 1 NC_010612.1 hypothetical protein 5403963 6228676 MMAR_4394 Mycobacterium marinum M hypothetical protein YP_001852656.1 5403121 R 216594 CDS YP_001852657.1 183984366 6228677 5404211..5405248 1 NC_010612.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase 5405248 echA9 6228677 echA9 Mycobacterium marinum M 3-hydroxyisobutyryl-CoA hydrolase YP_001852657.1 5404211 D 216594 CDS YP_001852658.1 183984367 6228678 5405260..5406033 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 5406033 echA8 6228678 echA8 Mycobacterium marinum M enoyl-CoA hydratase YP_001852658.1 5405260 D 216594 CDS YP_001852659.1 183984368 6228679 5406045..5407790 1 NC_010612.1 hypothetical protein 5407790 6228679 MMAR_4397 Mycobacterium marinum M hypothetical protein YP_001852659.1 5406045 D 216594 CDS YP_001852660.1 183984369 6228680 5408042..5410774 1 NC_010612.1 PE-PGRS family protein 5410774 6228680 MMAR_4398 Mycobacterium marinum M PE-PGRS family protein YP_001852660.1 5408042 D 216594 CDS YP_001852661.1 183984370 6228681 5410995..5413727 1 NC_010612.1 PE-PGRS family protein 5413727 6228681 MMAR_4399 Mycobacterium marinum M PE-PGRS family protein YP_001852661.1 5410995 D 216594 CDS YP_001852662.1 183984371 6228682 complement(5413760..5414143) 1 NC_010612.1 hypothetical protein 5414143 6228682 MMAR_4400 Mycobacterium marinum M hypothetical protein YP_001852662.1 5413760 R 216594 CDS YP_001852663.1 183984372 6228683 complement(5414143..5414637) 1 NC_010612.1 hypothetical protein 5414637 6228683 MMAR_4401 Mycobacterium marinum M hypothetical protein YP_001852663.1 5414143 R 216594 CDS YP_001852664.1 183984373 6228684 5414843..5415310 1 NC_010612.1 lipoprotein LpqV 5415310 lpqV 6228684 lpqV Mycobacterium marinum M lipoprotein LpqV YP_001852664.1 5414843 D 216594 CDS YP_001852665.1 183984374 6228685 5415413..5416477 1 NC_010612.1 hypothetical protein 5416477 6228685 MMAR_4403 Mycobacterium marinum M hypothetical protein YP_001852665.1 5415413 D 216594 CDS YP_001852666.1 183984375 6228686 complement(5416478..5417347) 1 NC_010612.1 hypothetical protein 5417347 6228686 MMAR_4404 Mycobacterium marinum M hypothetical protein YP_001852666.1 5416478 R 216594 CDS YP_001852667.1 183984376 6228687 complement(5417371..5418243) 1 NC_010612.1 hypothetical protein 5418243 6228687 MMAR_4405 Mycobacterium marinum M hypothetical protein YP_001852667.1 5417371 R 216594 CDS YP_001852668.1 183984377 6228688 complement(5418276..5418749) 1 NC_010612.1 hypothetical protein 5418749 6228688 MMAR_4406 Mycobacterium marinum M hypothetical protein YP_001852668.1 5418276 R 216594 CDS YP_001852669.1 183984378 6228689 complement(5418899..5421412) 1 NC_010612.1 PE-PGRS family protein 5421412 6228689 MMAR_4407 Mycobacterium marinum M PE-PGRS family protein YP_001852669.1 5418899 R 216594 CDS YP_001852670.1 183984379 6228690 complement(5421973..5422854) 1 NC_010612.1 hypothetical protein 5422854 6228690 MMAR_4408 Mycobacterium marinum M hypothetical protein YP_001852670.1 5421973 R 216594 CDS YP_001852671.1 183984380 6228691 complement(5422847..5423743) 1 NC_010612.1 acid phosphatase 5423743 6228691 MMAR_4409 Mycobacterium marinum M acid phosphatase YP_001852671.1 5422847 R 216594 CDS YP_001852672.1 183984381 6228692 complement(5423744..5425294) 1 NC_010612.1 thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]; arylsulfatase, AslA 5425294 aslA 6228692 aslA Mycobacterium marinum M arylsulfatase, AslA YP_001852672.1 5423744 R 216594 CDS YP_001852673.1 183984382 6228693 complement(5425406..5426464) 1 NC_010612.1 hypothetical protein 5426464 6228693 MMAR_4411 Mycobacterium marinum M hypothetical protein YP_001852673.1 5425406 R 216594 CDS YP_001852674.1 183984383 6228694 complement(5426572..5428203) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 5428203 fadD14 6228694 fadD14 Mycobacterium marinum M long-chain-fatty-acid--CoA ligase YP_001852674.1 5426572 R 216594 CDS YP_001852675.1 183984384 6228695 complement(5428325..5429524) 1 NC_010612.1 hypothetical protein 5429524 6228695 MMAR_4413 Mycobacterium marinum M hypothetical protein YP_001852675.1 5428325 R 216594 CDS YP_001852676.1 183984385 6228696 complement(5429919..5430704) 1 NC_010612.1 hypothetical protein 5430704 6228696 MMAR_4414 Mycobacterium marinum M hypothetical protein YP_001852676.1 5429919 R 216594 CDS YP_001852677.1 183984386 6228697 5430837..5431349 1 NC_010612.1 function unknown; contains a FMN-binding split barrel domain. possible role in the electron-transfer pathway. the FMN-binding split barrel is related to the ferredoxin reductase-like FAD-binding domain. flavodoxins are an example of a group of proteins with a tightly bound flavin mononucleotide (FMN) that mediate electron transfer at low redox potential; hypothetical protein 5431349 6228697 MMAR_4415 Mycobacterium marinum M hypothetical protein YP_001852677.1 5430837 D 216594 CDS YP_001852678.1 183984387 6228698 complement(5431369..5432955) 1 NC_010612.1 hypothetical protein 5432955 6228698 MMAR_4416 Mycobacterium marinum M hypothetical protein YP_001852678.1 5431369 R 216594 CDS YP_001852679.1 183984388 6228699 complement(5433015..5433791) 1 NC_010612.1 hypothetical protein 5433791 6228699 MMAR_4417 Mycobacterium marinum M hypothetical protein YP_001852679.1 5433015 R 216594 CDS YP_001852680.1 183984389 6228700 complement(5433875..5434498) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 5434498 6228700 MMAR_4418 Mycobacterium marinum M transcriptional regulatory protein YP_001852680.1 5433875 R 216594 CDS YP_001852681.1 183984390 6228701 5434560..5435363 1 NC_010612.1 hypothetical protein 5435363 6228701 MMAR_4419 Mycobacterium marinum M hypothetical protein YP_001852681.1 5434560 D 216594 CDS YP_001852682.1 183984391 6228702 5435560..5438004 1 NC_010612.1 the glycine cleavage system catalyzes the degradation of glycine [catalytic activity: (6S)- tetrahydrofolate + s-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein]; aminomethyltransferase GcvT_2 5438004 gcvT_2 6228702 gcvT_2 Mycobacterium marinum M aminomethyltransferase GcvT_2 YP_001852682.1 5435560 D 216594 CDS YP_001852683.1 183984392 6228703 5438011..5439153 1 NC_010612.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 5439153 solA 6228703 solA Mycobacterium marinum M N-methyltryptophan oxidase YP_001852683.1 5438011 D 216594 CDS YP_001852684.1 183984393 6228704 5439150..5440298 1 NC_010612.1 function unknown; involved in cellular metabolism; dioxygenase 5440298 6228704 MMAR_4422 Mycobacterium marinum M dioxygenase YP_001852684.1 5439150 D 216594 CDS YP_001852685.1 183984394 6228705 5440310..5441140 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 5441140 6228705 MMAR_4423 Mycobacterium marinum M transcriptional regulatory protein YP_001852685.1 5440310 D 216594 CDS YP_001852686.1 183984395 6228706 5441306..5442022 1 NC_010612.1 hypothetical protein 5442022 6228706 MMAR_4424 Mycobacterium marinum M hypothetical protein YP_001852686.1 5441306 D 216594 CDS YP_001852687.1 183984396 6228707 complement(5442125..5442868) 1 NC_010612.1 function unknown but has domain identity to UbiE, a methylase involved in ubiquinone/menaquinone biosynthesis; methylase 5442868 6228707 MMAR_4425 Mycobacterium marinum M methylase YP_001852687.1 5442125 R 216594 CDS YP_001852688.1 183984397 6228708 complement(5442929..5443999) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 5443999 6228708 MMAR_4426 Mycobacterium marinum M transcriptional regulatory protein YP_001852688.1 5442929 R 216594 CDS YP_001852689.1 183984398 6228709 5444274..5445830 1 NC_010612.1 function unknown; probably involved in cellular metabolism, probably electron-transfer-linked; dehydrogenase fad flavoprotein GMC oxidoreductase 5445830 6228709 MMAR_4427 Mycobacterium marinum M dehydrogenase fad flavoprotein GMC oxidoreductase YP_001852689.1 5444274 D 216594 CDS YP_001852690.1 183984399 6228710 complement(5445832..5446710) 1 NC_010612.1 may act on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds [catalytic activity: 1-haloalkane + H(2)O, a primary alcohol + halide]; haloalkane dehalogenase 5446710 6228710 MMAR_4428 Mycobacterium marinum M haloalkane dehalogenase YP_001852690.1 5445832 R 216594 CDS YP_001852691.1 183984400 6228711 complement(5447124..5449940) 1 NC_010612.1 thought to be involved in fatty acid transport; transmembrane transport protein MmpL 5449940 6228711 MMAR_4429 Mycobacterium marinum M transmembrane transport protein MmpL YP_001852691.1 5447124 R 216594 CDS YP_001852692.1 183984401 6228712 complement(5450494..5451864) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 138B1 Cyp138B1 5451864 cyp138B1 6228712 cyp138B1 Mycobacterium marinum M cytochrome P450 138B1 Cyp138B1 YP_001852692.1 5450494 R 216594 CDS YP_001852693.1 183984402 6228713 complement(5451898..5452848) 1 NC_010612.1 hypothetical protein 5452848 6228713 MMAR_4431 Mycobacterium marinum M hypothetical protein YP_001852693.1 5451898 R 216594 CDS YP_001852694.1 183984403 6228714 complement(5452871..5453572) 1 NC_010612.1 hypothetical protein 5453572 6228714 MMAR_4432 Mycobacterium marinum M hypothetical protein YP_001852694.1 5452871 R 216594 CDS YP_001852695.1 183984404 6228715 complement(5453621..5454790) 1 NC_010612.1 function unknown; domain identity suggests BtaA, s- adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase - with a potential role in methylation during lipid biosynthesis; methylase 5454790 6228715 MMAR_4433 Mycobacterium marinum M methylase YP_001852695.1 5453621 R 216594 CDS YP_001852696.1 183984405 6228716 5455068..5455553 1 NC_010612.1 hypothetical protein 5455553 6228716 MMAR_4434 Mycobacterium marinum M hypothetical protein YP_001852696.1 5455068 D 216594 CDS YP_001852697.1 183984406 6228717 complement(5456235..5456615) 1 NC_010612.1 hypothetical protein 5456615 6228717 MMAR_4435 Mycobacterium marinum M hypothetical protein YP_001852697.1 5456235 R 216594 CDS YP_001852698.1 183984407 6228718 5456700..5457338 1 NC_010612.1 hypothetical protein 5457338 6228718 MMAR_4436 Mycobacterium marinum M hypothetical protein YP_001852698.1 5456700 D 216594 CDS YP_001852699.1 183984408 6228719 5457504..5458208 1 NC_010612.1 hypothetical protein 5458208 6228719 MMAR_4437 Mycobacterium marinum M hypothetical protein YP_001852699.1 5457504 D 216594 CDS YP_001852700.1 183984409 6228720 complement(5458337..5459869) 1 NC_010612.1 hypothetical protein 5459869 6228720 MMAR_4438 Mycobacterium marinum M hypothetical protein YP_001852700.1 5458337 R 216594 CDS YP_001852701.1 183984410 6228721 complement(5460261..5460929) 1 NC_010612.1 hypothetical protein 5460929 6228721 MMAR_4439 Mycobacterium marinum M hypothetical protein YP_001852701.1 5460261 R 216594 CDS YP_001852702.1 183984411 6228722 complement(5460926..5461981) 1 NC_010612.1 hypothetical protein 5461981 6228722 MMAR_4440 Mycobacterium marinum M hypothetical protein YP_001852702.1 5460926 R 216594 CDS YP_001852703.1 183984412 6228723 5462196..5462510 1 NC_010612.1 hypothetical protein 5462510 6228723 MMAR_4441 Mycobacterium marinum M hypothetical protein YP_001852703.1 5462196 D 216594 CDS YP_001852704.1 183984413 6228724 complement(5462521..5463915) 1 NC_010612.1 integration of phage genome into host DNA; prophage integrase 5463915 6228724 MMAR_4442 Mycobacterium marinum M prophage integrase YP_001852704.1 5462521 R 216594 CDS YP_001852705.1 183984414 6228725 complement(5464024..5464686) 1 NC_010612.1 phage DNA recombination function; site-specific recombinase 5464686 6228725 MMAR_4443 Mycobacterium marinum M site-specific recombinase YP_001852705.1 5464024 R 216594 CDS YP_001852706.1 183984415 6228726 complement(5464697..5465899) 1 NC_010612.1 hypothetical protein 5465899 6228726 MMAR_4444 Mycobacterium marinum M hypothetical protein YP_001852706.1 5464697 R 216594 CDS YP_001852707.1 183984416 6228727 complement(5465896..5466138) 1 NC_010612.1 hypothetical protein 5466138 6228727 MMAR_4445 Mycobacterium marinum M hypothetical protein YP_001852707.1 5465896 R 216594 CDS YP_001852708.1 183984417 6228728 complement(5466465..5466848) 1 NC_010612.1 hypothetical protein 5466848 6228728 MMAR_4446 Mycobacterium marinum M hypothetical protein YP_001852708.1 5466465 R 216594 CDS YP_001852709.1 183984418 6228729 complement(5467159..5467785) 1 NC_010612.1 hypothetical protein 5467785 6228729 MMAR_4447 Mycobacterium marinum M hypothetical protein YP_001852709.1 5467159 R 216594 CDS YP_001852710.1 183984419 6228730 5468224..5469375 1 NC_010612.1 hypothetical protein 5469375 6228730 MMAR_4448 Mycobacterium marinum M hypothetical protein YP_001852710.1 5468224 D 216594 CDS YP_001852711.1 183984420 6228731 5469388..5469633 1 NC_010612.1 hypothetical protein 5469633 6228731 MMAR_4449 Mycobacterium marinum M hypothetical protein YP_001852711.1 5469388 D 216594 CDS YP_001852712.1 183984421 6228732 complement(5469703..5470605) 1 NC_010612.1 hypothetical protein 5470605 6228732 MMAR_4450 Mycobacterium marinum M hypothetical protein YP_001852712.1 5469703 R 216594 CDS YP_001852713.1 183984422 6228734 5471205..5472029 1 NC_010612.1 PE family protein 5472029 6228734 MMAR_4451 Mycobacterium marinum M PE family protein YP_001852713.1 5471205 D 216594 CDS YP_001852714.1 183984423 6228735 5472099..5473271 1 NC_010612.1 PPE family protein 5473271 6228735 MMAR_4452 Mycobacterium marinum M PPE family protein YP_001852714.1 5472099 D 216594 CDS YP_001852715.1 183984424 6228736 5473419..5473715 1 NC_010612.1 EsaT-6 like protein EsxP 5473715 esxP 6228736 esxP Mycobacterium marinum M EsaT-6 like protein EsxP YP_001852715.1 5473419 D 216594 CDS YP_001852716.1 183984425 6228737 5473754..5474038 1 NC_010612.1 EsaT-6 like protein EsxN 5474038 esxN_1 6228737 esxN_1 Mycobacterium marinum M EsaT-6 like protein EsxN YP_001852716.1 5473754 D 216594 CDS YP_001852717.1 183984426 6228738 5474308..5475072 1 NC_010612.1 sensor part of the two-component regulatory system TrcS/TrcR. involved in transcriptional autoactivation: TrcR activates its own expression by interacting with the AT-rich sequence of the TrcR promoter; two-component transcriptional regulator TrcR 5475072 trcR 6228738 trcR Mycobacterium marinum M two-component transcriptional regulator TrcR YP_001852717.1 5474308 D 216594 CDS YP_001852718.1 183984427 6228739 5475080..5476624 1 NC_010612.1 sensor part of the two-component regulatory system TrcS/TrcR; two-component sensor histidine kinase TrcS 5476624 trcS 6228739 trcS Mycobacterium marinum M two-component sensor histidine kinase TrcS YP_001852718.1 5475080 D 216594 CDS YP_001852719.1 183984428 6228740 5476662..5477402 1 NC_010612.1 function unknown, possibly involved in amino acid transport and metabolism; hydantoin racemase 5477402 6228740 MMAR_4457 Mycobacterium marinum M hydantoin racemase YP_001852719.1 5476662 D 216594 CDS YP_001852720.1 183984429 6228741 complement(5477489..5477782) 1 NC_010612.1 hypothetical protein 5477782 6228741 MMAR_4458 Mycobacterium marinum M hypothetical protein YP_001852720.1 5477489 R 216594 CDS YP_001852721.1 183984430 6228742 complement(5477886..5478833) 1 NC_010612.1 function unknown; identity to GppA, exopolyphosphatase [nucleotide transport and metabolism / inorganic ion transport and metabolism]; hypothetical protein 5478833 6228742 MMAR_4459 Mycobacterium marinum M hypothetical protein YP_001852721.1 5477886 R 216594 CDS YP_001852722.1 183984431 6228743 complement(5478853..5479344) 1 NC_010612.1 hypothetical protein 5479344 6228743 MMAR_4460 Mycobacterium marinum M hypothetical protein YP_001852722.1 5478853 R 216594 CDS YP_001852723.1 183984432 6228744 complement(5479337..5480038) 1 NC_010612.1 hypothetical protein 5480038 6228744 MMAR_4461 Mycobacterium marinum M hypothetical protein YP_001852723.1 5479337 R 216594 CDS YP_001852724.1 183984433 6228745 complement(5480072..5481358) 1 NC_010612.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 5481358 eno 6228745 eno Mycobacterium marinum M phosphopyruvate hydratase YP_001852724.1 5480072 R 216594 CDS YP_001852725.1 183984434 6228746 complement(5481439..5482170) 1 NC_010612.1 lipoprotein LpqU 5482170 lpqU 6228746 lpqU Mycobacterium marinum M lipoprotein LpqU YP_001852725.1 5481439 R 216594 CDS YP_001852726.1 183984435 6228747 complement(5482525..5483625) 1 NC_010612.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 5483625 6228747 MMAR_4464 Mycobacterium marinum M nucleoside triphosphate pyrophosphohydrolase YP_001852726.1 5482525 R 216594 CDS YP_001852727.1 183984436 6228748 complement(5483622..5487290) 1 NC_010612.1 involved in nucleotide excision repair. necessary for strand-specific repair. a lesion in the template strand blocks the RNA polymerase complex (RNAP). the RNAP- DNA-RNA complex is specifically recognized by TrcF which releases RNAP and the truncated transcript; the TcrF may replace RNAP at the lesion site and then recruit the UvrA/B/C repair system; transcription-repair coupling factor Mfd (TrcF) 5487290 mfd 6228748 mfd Mycobacterium marinum M transcription-repair coupling factor Mfd (TrcF) YP_001852727.1 5483622 R 216594 CDS YP_001852728.1 183984437 6228749 complement(5487357..5487986) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 5487986 6228749 MMAR_4466 Mycobacterium marinum M TetR family transcriptional regulator YP_001852728.1 5487357 R 216594 CDS YP_001852729.1 183984438 6228751 5488427..5489905 1 NC_010612.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 5489905 glmU 6228751 glmU Mycobacterium marinum M bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_001852729.1 5488427 D 216594 CDS YP_001852730.1 183984439 6228752 5490018..5490998 1 NC_010612.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 5490998 prsA 6228752 prsA Mycobacterium marinum M ribose-phosphate pyrophosphokinase YP_001852730.1 5490018 D 216594 CDS YP_001852731.1 183984440 6228753 5490999..5491367 1 NC_010612.1 arsenate reductase 5491367 6228753 MMAR_4469 Mycobacterium marinum M arsenate reductase YP_001852731.1 5490999 D 216594 CDS YP_001852732.1 183984441 6228754 5491364..5492020 1 NC_010612.1 lipoprotein LpqT 5492020 lpqT 6228754 lpqT Mycobacterium marinum M lipoprotein LpqT YP_001852732.1 5491364 D 216594 CDS YP_001852733.1 183984442 6228756 5493105..5493749 1 NC_010612.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25/general stress protein Ctc 5493749 rplY 6228756 rplY Mycobacterium marinum M 50S ribosomal protein L25/general stress protein Ctc YP_001852733.1 5493105 D 216594 CDS YP_001852734.1 183984443 6228757 5493762..5494337 1 NC_010612.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 5494337 pth 6228757 pth Mycobacterium marinum M peptidyl-tRNA hydrolase YP_001852734.1 5493762 D 216594 CDS YP_001852735.1 183984444 6228758 complement(5494351..5495259) 1 NC_010612.1 hypothetical protein 5495259 6228758 MMAR_4474 Mycobacterium marinum M hypothetical protein YP_001852735.1 5494351 R 216594 CDS YP_001852736.1 183984445 6228759 5495603..5497123 1 NC_010612.1 PE-PGRS family protein 5497123 6228759 MMAR_4475 Mycobacterium marinum M PE-PGRS family protein YP_001852736.1 5495603 D 216594 CDS YP_001852737.1 183984446 6228760 complement(5497211..5498845) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 5498845 pks16 6228760 pks16 Mycobacterium marinum M long-chain-fatty-acid--CoA ligase YP_001852737.1 5497211 R 216594 CDS YP_001852738.1 183984447 6228761 complement(5499211..5500134) 1 NC_010612.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 5500134 ispE 6228761 ispE Mycobacterium marinum M 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_001852738.1 5499211 R 216594 CDS YP_001852739.1 183984448 6228762 complement(5500232..5501056) 1 NC_010612.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 5501056 ksgA 6228762 ksgA Mycobacterium marinum M dimethyladenosine transferase YP_001852739.1 5500232 R 216594 CDS YP_001852740.1 183984449 6228763 complement(5501161..5502249) 1 NC_010612.1 thought to promote the resuscitation and growth of dormant, nongrowing cell. could also stimulates the growth of several other high G+C Gram+ organisms, E.G. mycobacterium avium, mycobacterium bovis (BCG), mycobacterium kansasii, mycobacterium smegmatis; resuscitation-promoting factor RpfB 5502249 rpfB 6228763 rpfB Mycobacterium marinum M resuscitation-promoting factor RpfB YP_001852740.1 5501161 R 216594 CDS YP_001852741.1 183984450 6228764 complement(5502459..5503307) 1 NC_010612.1 DNAse involved in proteins export. this sec- independent pathway is termed tat for twin-arginine translocation system. this system mainly transports proteins with bound cofactors that require folding prior to export (by similarity); deoxyribonuclease TatD 5503307 tatD 6228764 tatD Mycobacterium marinum M deoxyribonuclease TatD YP_001852741.1 5502459 R 216594 CDS YP_001852742.1 183984451 6228765 5503341..5504897 1 NC_010612.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 5504897 metS 6228765 metS Mycobacterium marinum M methionyl-tRNA synthetase YP_001852742.1 5503341 D 216594 CDS YP_001852743.1 183984452 6228766 5505172..5505858 1 NC_010612.1 function unknown but may be involved in RNA methylation; methyltransferase 5505858 6228766 MMAR_4482 Mycobacterium marinum M methyltransferase YP_001852743.1 5505172 D 216594 CDS YP_001852744.1 183984453 6228767 complement(5505905..5507278) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 135B3 Cyp135B3 5507278 cyp135B3 6228767 cyp135B3 Mycobacterium marinum M cytochrome P450 135B3 Cyp135B3 YP_001852744.1 5505905 R 216594 CDS YP_001852745.1 183984454 6228768 5508477..5509043 1 NC_010612.1 involved in cysteine biosynthesis [catalytic activity: acetyl-CoA + L-serine = CoA + O-acetyl-L- serine]; serine acetyltransferase CysE 5509043 cysE_1 6228768 cysE_1 Mycobacterium marinum M serine acetyltransferase CysE YP_001852745.1 5508477 D 216594 CDS YP_001852746.1 183984455 6228769 complement(5509111..5510814) 1 NC_010612.1 hypothetical protein 5510814 6228769 MMAR_4485 Mycobacterium marinum M hypothetical protein YP_001852746.1 5509111 R 216594 CDS YP_001852747.1 183984456 6228770 5511312..5512496 1 NC_010612.1 function unknown, probably involved in cellular metabolism; dehydrogenase 5512496 6228770 MMAR_4486 Mycobacterium marinum M dehydrogenase YP_001852747.1 5511312 D 216594 CDS YP_001852748.1 183984457 6228771 5512493..5513398 1 NC_010612.1 the sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released; alternative RNA polymerase sigma factor 5513398 6228771 MMAR_4487 Mycobacterium marinum M alternative RNA polymerase sigma factor YP_001852748.1 5512493 D 216594 CDS YP_001852749.1 183984458 6228772 5513460..5514773 1 NC_010612.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; aminodeoxychorismate synthase component I 5514773 pabD 6228772 pabD Mycobacterium marinum M aminodeoxychorismate synthase component I YP_001852749.1 5513460 D 216594 CDS YP_001852750.1 183984459 6228773 5514880..5516226 1 NC_010612.1 hypothetical protein 5516226 6228773 MMAR_4489 Mycobacterium marinum M hypothetical protein YP_001852750.1 5514880 D 216594 CDS YP_001852751.1 183984460 6228774 complement(5516234..5517088) 1 NC_010612.1 hypothetical protein 5517088 6228774 MMAR_4490 Mycobacterium marinum M hypothetical protein YP_001852751.1 5516234 R 216594 CDS YP_001852752.1 183984461 6228775 5517114..5518670 1 NC_010612.1 hypothetical protein 5518670 6228775 MMAR_4491 Mycobacterium marinum M hypothetical protein YP_001852752.1 5517114 D 216594 CDS YP_001852753.1 183984462 6228776 complement(5518667..5519875) 1 NC_010612.1 catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 5519875 arcA 6228776 arcA Mycobacterium marinum M arginine deiminase YP_001852753.1 5518667 R 216594 CDS YP_001852754.1 183984463 6228777 5519934..5520551 1 NC_010612.1 hypothetical protein 5520551 6228777 MMAR_4493 Mycobacterium marinum M hypothetical protein YP_001852754.1 5519934 D 216594 CDS YP_001852755.1 183984464 6228778 complement(5520577..5521230) 1 NC_010612.1 hypothetical protein 5521230 6228778 MMAR_4494 Mycobacterium marinum M hypothetical protein YP_001852755.1 5520577 R 216594 CDS YP_001852756.1 183984465 6228779 complement(5521258..5521935) 1 NC_010612.1 hypothetical protein 5521935 6228779 MMAR_4495 Mycobacterium marinum M hypothetical protein YP_001852756.1 5521258 R 216594 CDS YP_001852757.1 183984466 6228780 complement(5522008..5522958) 1 NC_010612.1 hypothetical protein 5522958 6228780 MMAR_4496 Mycobacterium marinum M hypothetical protein YP_001852757.1 5522008 R 216594 CDS YP_001852758.1 183984467 6228781 5523173..5523919 1 NC_010612.1 thought to cause methylation; methyltransferase 5523919 6228781 MMAR_4497 Mycobacterium marinum M methyltransferase YP_001852758.1 5523173 D 216594 CDS YP_001852759.1 183984468 6228782 complement(5523955..5524206) 1 NC_010612.1 hypothetical protein 5524206 6228782 MMAR_4498 Mycobacterium marinum M hypothetical protein YP_001852759.1 5523955 R 216594 CDS YP_001852760.1 183984469 6228783 complement(5524321..5525115) 1 NC_010612.1 hypothetical protein 5525115 6228783 MMAR_4499 Mycobacterium marinum M hypothetical protein YP_001852760.1 5524321 R 216594 CDS YP_001852761.1 183984470 6228784 5525226..5525762 1 NC_010612.1 hypothetical protein 5525762 6228784 MMAR_4500 Mycobacterium marinum M hypothetical protein YP_001852761.1 5525226 D 216594 CDS YP_001852762.1 183984471 6228785 5526073..5527245 1 NC_010612.1 PPE family protein 5527245 6228785 MMAR_4501 Mycobacterium marinum M PPE family protein YP_001852762.1 5526073 D 216594 CDS YP_001852763.1 183984472 6228786 5527434..5528300 1 NC_010612.1 function unknown, possibly involved in cell envelope biogenesis, outer membrane; teichoic acid biosynthesis protein 5528300 6228786 MMAR_4502 Mycobacterium marinum M teichoic acid biosynthesis protein YP_001852763.1 5527434 D 216594 CDS YP_001852764.1 183984473 6228787 5528317..5529822 1 NC_010612.1 function unknown, possibly involved in lipopolysaccharide synthesis; hypothetical protein 5529822 6228787 MMAR_4503 Mycobacterium marinum M hypothetical protein YP_001852764.1 5528317 D 216594 CDS YP_001852765.1 183984474 6228788 5529837..5531312 1 NC_010612.1 function unknown, possible membrane protein involved in the export of O-antigen and teichoic acid; hypothetical protein 5531312 6228788 MMAR_4504 Mycobacterium marinum M hypothetical protein YP_001852765.1 5529837 D 216594 CDS YP_001852766.1 183984475 6228789 5531309..5533300 1 NC_010612.1 probably involved in cell wall synthesis; glycosyltransferase 5533300 6228789 MMAR_4505 Mycobacterium marinum M glycosyltransferase YP_001852766.1 5531309 D 216594 CDS YP_001852767.1 183984476 6228790 5533297..5534352 1 NC_010612.1 function unknown, contains RfaG, glycosyltransferase domain. may be involved in cell envelope biogenesis, outer membrane; hypothetical protein 5534352 6228790 MMAR_4506 Mycobacterium marinum M hypothetical protein YP_001852767.1 5533297 D 216594 CDS YP_001852768.1 183984477 6228791 complement(5534367..5535326) 1 NC_010612.1 hypothetical protein 5535326 6228791 MMAR_4507 Mycobacterium marinum M hypothetical protein YP_001852768.1 5534367 R 216594 CDS YP_001852769.1 183984478 6228792 complement(5535361..5537322) 1 NC_010612.1 hypothetical protein 5537322 6228792 MMAR_4508 Mycobacterium marinum M hypothetical protein YP_001852769.1 5535361 R 216594 CDS YP_001852770.1 183984479 6228793 5537759..5538718 1 NC_010612.1 hypothetical protein 5538718 6228793 MMAR_4509 Mycobacterium marinum M hypothetical protein YP_001852770.1 5537759 D 216594 CDS YP_001852771.1 183984480 6228794 complement(5538698..5539495) 1 NC_010612.1 hypothetical protein 5539495 6228794 MMAR_4510 Mycobacterium marinum M hypothetical protein YP_001852771.1 5538698 R 216594 CDS YP_001852772.1 183984481 6228795 complement(5539596..5540261) 1 NC_010612.1 hypothetical protein 5540261 6228795 MMAR_4511 Mycobacterium marinum M hypothetical protein YP_001852772.1 5539596 R 216594 CDS YP_001852773.1 183984482 6228796 5540420..5541178 1 NC_010612.1 function unknown; hydrolytic enzyme probably involved in cellular metabolism; amidohydrolase 5541178 6228796 MMAR_4512 Mycobacterium marinum M amidohydrolase YP_001852773.1 5540420 D 216594 CDS YP_001852774.1 183984483 6228797 complement(5541157..5541918) 1 NC_010612.1 hypothetical protein 5541918 6228797 MMAR_4513 Mycobacterium marinum M hypothetical protein YP_001852774.1 5541157 R 216594 CDS YP_001852775.1 183984484 6228798 complement(5542012..5543133) 1 NC_010612.1 function unknown; probably involved in cellular metabolism; glycosyl transferase family protein 5543133 6228798 MMAR_4514 Mycobacterium marinum M glycosyl transferase family protein YP_001852775.1 5542012 R 216594 CDS YP_001852776.1 183984485 6228799 complement(5543130..5544605) 1 NC_010612.1 hypothetical protein 5544605 6228799 MMAR_4515 Mycobacterium marinum M hypothetical protein YP_001852776.1 5543130 R 216594 CDS YP_001852777.1 183984486 6228800 complement(5544602..5545987) 1 NC_010612.1 function unknown, possibly involved in cell envelope biogenesis, outer membrane; hypothetical protein 5545987 6228800 MMAR_4516 Mycobacterium marinum M hypothetical protein YP_001852777.1 5544602 R 216594 CDS YP_001852778.1 183984487 6228801 5546323..5547105 1 NC_010612.1 hypothetical protein 5547105 6228801 MMAR_4517 Mycobacterium marinum M hypothetical protein YP_001852778.1 5546323 D 216594 CDS YP_001852779.1 183984488 6228803 complement(5547340..5548518) 1 NC_010612.1 hypothetical protein 5548518 6228803 MMAR_4518 Mycobacterium marinum M hypothetical protein YP_001852779.1 5547340 R 216594 CDS YP_001852780.1 183984489 6228804 complement(5548725..5549378) 1 NC_010612.1 this enzyme acetylates the N-terminal alanine of ribosomal protein S5 [catalytic activity: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N- acetyl-L-alanine]; ribosomal-protein-alanine acetyltransferase RimJ 5549378 rimJ 6228804 rimJ Mycobacterium marinum M ribosomal-protein-alanine acetyltransferase RimJ YP_001852780.1 5548725 R 216594 CDS YP_001852781.1 183984490 6228805 complement(5549401..5550690) 1 NC_010612.1 involved in molybdenum cofactor biosynthesis: involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes; molybdopterin biosynthesis protein MoeA1 5550690 moeA1 6228805 moeA1 Mycobacterium marinum M molybdopterin biosynthesis protein MoeA1 YP_001852781.1 5549401 R 216594 CDS YP_001852782.1 183984491 6228806 complement(5550742..5551659) 1 NC_010612.1 may play a role in stationary phase survival [catalytic activity: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose]; UTP--glucose-1-phosphate uridylyltransferase GalU 5551659 galU 6228806 galU Mycobacterium marinum M UTP--glucose-1-phosphate uridylyltransferase GalU YP_001852782.1 5550742 R 216594 CDS YP_001852783.1 183984492 6228807 5551737..5552330 1 NC_010612.1 hypothetical protein 5552330 6228807 MMAR_4522 Mycobacterium marinum M hypothetical protein YP_001852783.1 5551737 D 216594 CDS YP_001852784.1 183984493 6228808 5552405..5552740 1 NC_010612.1 putative serine rich protein 5552740 6228808 MMAR_4523 Mycobacterium marinum M putative serine rich protein YP_001852784.1 5552405 D 216594 CDS YP_001852785.1 183984494 6228809 5552807..5553466 1 NC_010612.1 hypothetical protein 5553466 6228809 MMAR_4524 Mycobacterium marinum M hypothetical protein YP_001852785.1 5552807 D 216594 CDS YP_001852786.1 183984495 6228810 5553543..5553998 1 NC_010612.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 5553998 mscL 6228810 mscL Mycobacterium marinum M large-conductance mechanosensitive channel YP_001852786.1 5553543 D 216594 CDS YP_001852787.1 183984496 6228811 complement(5554018..5554563) 1 NC_010612.1 thought to be involved in molybdopterin biosynthesis. catalyzes the dehydratation of 4A- hydroxytetrahydropterins [catalytic activity: (6R)-6-(L- erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro -4 A- hydroxypterin = (6R)-6-(L-erythro-1,2- dihydroxypropyl)- 7,8-dihydro-6H-pterin + H(2)O.]; pterin-4-alpha-carbinolamine dehydratase MoaB2 5554563 moaB2 6228811 moaB2 Mycobacterium marinum M pterin-4-alpha-carbinolamine dehydratase MoaB2 YP_001852787.1 5554018 R 216594 CDS YP_001852788.1 183984497 6228812 complement(5554560..5555999) 1 NC_010612.1 function unknown, possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residues); serine protease PepD 5555999 pepD 6228812 pepD Mycobacterium marinum M serine protease PepD YP_001852788.1 5554560 R 216594 CDS YP_001852789.1 183984498 6228813 complement(5556099..5557634) 1 NC_010612.1 sensor part of a two-component regulatory system (supposed MprAB system); two-component sensor kinase MprB 5557634 mprB 6228813 mprB Mycobacterium marinum M two-component sensor kinase MprB YP_001852789.1 5556099 R 216594 CDS YP_001852790.1 183984499 6228814 complement(5557634..5558332) 1 NC_010612.1 regulator part of a two-component regulatory system (supposed MprAB system); two component response transcriptional regulatory protein MprA 5558332 mprA 6228814 mprA Mycobacterium marinum M two component response transcriptional regulatory protein MprA YP_001852790.1 5557634 R 216594 CDS YP_001852791.1 183984500 6228815 complement(5558599..5558772) 1 NC_010612.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 5558772 rpmF 6228815 rpmF Mycobacterium marinum M 50S ribosomal protein L32 YP_001852791.1 5558599 R 216594 CDS YP_001852792.1 183984501 6228816 5559038..5560750 1 NC_010612.1 hypothetical protein 5560750 6228816 MMAR_4531 Mycobacterium marinum M hypothetical protein YP_001852792.1 5559038 D 216594 CDS YP_001852793.1 183984502 6228817 5560747..5561895 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE13 5561895 fadE13 6228817 fadE13 Mycobacterium marinum M acyl-CoA dehydrogenase FadE13 YP_001852793.1 5560747 D 216594 CDS YP_001852794.1 183984503 6228818 5561945..5563540 1 NC_010612.1 involved in fatty acid metabolism; acetyl-/propionyl-CoA carboxylase subunit beta 5563540 accD2 6228818 accD2 Mycobacterium marinum M acetyl-/propionyl-CoA carboxylase subunit beta YP_001852794.1 5561945 D 216594 CDS YP_001852795.1 183984504 6228819 5563540..5565528 1 NC_010612.1 this protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. involved in the first step of long-chain fatty acid synthesis [catalytic activity: ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + phosphate + carboxybiotin-carboxyl-carrier protein]; acetyl-/propionyl-coenzyme A carboxylase alpha chain, AccA2 5565528 accA2 6228819 accA2 Mycobacterium marinum M acetyl-/propionyl-coenzyme A carboxylase alpha chain, AccA2 YP_001852795.1 5563540 D 216594 CDS YP_001852796.1 183984505 6228820 5565528..5566694 1 NC_010612.1 function unknown, but involved in lipid metabolism; acyl-CoA dehydrogenase FadE12 5566694 fadE12 6228820 fadE12 Mycobacterium marinum M acyl-CoA dehydrogenase FadE12 YP_001852796.1 5565528 D 216594 CDS YP_001852797.1 183984506 6228821 5566705..5567478 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 5567478 echA7 6228821 echA7 Mycobacterium marinum M enoyl-CoA hydratase YP_001852797.1 5566705 D 216594 CDS YP_001852798.1 183984507 6228822 5567529..5567792 1 NC_010612.1 PE-PGRS family protein 5567792 6228822 MMAR_4537 Mycobacterium marinum M PE-PGRS family protein YP_001852798.1 5567529 D 216594 CDS YP_001852799.1 183984508 6228823 5567853..5568041 1 NC_010612.1 hypothetical protein 5568041 6228823 MMAR_4538 Mycobacterium marinum M hypothetical protein YP_001852799.1 5567853 D 216594 CDS YP_001852800.1 183984509 6228824 5568148..5568750 1 NC_010612.1 hypothetical protein 5568750 6228824 MMAR_4539 Mycobacterium marinum M hypothetical protein YP_001852800.1 5568148 D 216594 CDS YP_001852801.1 183984510 6228825 complement(5568778..5570775) 1 NC_010612.1 hypothetical protein 5570775 6228825 MMAR_4540 Mycobacterium marinum M hypothetical protein YP_001852801.1 5568778 R 216594 CDS YP_001852802.1 183984511 6228826 complement(5570768..5572159) 1 NC_010612.1 chelation, introducing a magnesium ion into specific substrate; magnesium chelatase 5572159 6228826 MMAR_4541 Mycobacterium marinum M magnesium chelatase YP_001852802.1 5570768 R 216594 CDS YP_001852803.1 183984512 6228827 complement(5572239..5573810) 1 NC_010612.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 5573810 purH 6228827 purH Mycobacterium marinum M bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_001852803.1 5572239 R 216594 CDS YP_001852804.1 183984513 6228828 complement(5573807..5574454) 1 NC_010612.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 5574454 purN 6228828 purN Mycobacterium marinum M phosphoribosylglycinamide formyltransferase YP_001852804.1 5573807 R 216594 CDS YP_001852805.1 183984514 6228829 complement(5574507..5575925) 1 NC_010612.1 integral membrane protein 5575925 6228829 MMAR_4544 Mycobacterium marinum M integral membrane protein YP_001852805.1 5574507 R 216594 CDS YP_001852806.1 183984515 6228830 complement(5575965..5576879) 1 NC_010612.1 transmembrane protein 5576879 6228830 MMAR_4545 Mycobacterium marinum M transmembrane protein YP_001852806.1 5575965 R 216594 CDS YP_001852807.1 183984516 6228831 5577116..5577949 1 NC_010612.1 oxidoreductase 5577949 6228831 MMAR_4546 Mycobacterium marinum M oxidoreductase YP_001852807.1 5577116 D 216594 CDS YP_001852808.1 183984517 6228832 complement(5577957..5579477) 1 NC_010612.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 5579477 6228832 MMAR_4547 Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001852808.1 5577957 R 216594 CDS YP_001852809.1 183984518 6228833 5579641..5580972 1 NC_010612.1 PE-PGRS family protein 5580972 6228833 MMAR_4548 Mycobacterium marinum M PE-PGRS family protein YP_001852809.1 5579641 D 216594 CDS YP_001852810.1 183984519 6228834 complement(5581063..5581965) 1 NC_010612.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 5581965 sucD 6228834 sucD Mycobacterium marinum M succinyl-CoA synthetase subunit alpha YP_001852810.1 5581063 R 216594 CDS YP_001852811.1 183984520 6228835 complement(5581980..5583143) 1 NC_010612.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 5583143 sucC 6228835 sucC Mycobacterium marinum M succinyl-CoA synthetase subunit beta YP_001852811.1 5581980 R 216594 CDS YP_001852812.1 183984521 6228836 5583419..5584486 1 NC_010612.1 hypothetical protein 5584486 6228836 MMAR_4551 Mycobacterium marinum M hypothetical protein YP_001852812.1 5583419 D 216594 CDS YP_001852813.1 183984522 6228837 5584601..5585074 1 NC_010612.1 hypothetical protein 5585074 6228837 MMAR_4552 Mycobacterium marinum M hypothetical protein YP_001852813.1 5584601 D 216594 CDS YP_001852814.1 183984523 6228838 complement(5585153..5587462) 1 NC_010612.1 involved in nucleotide excision repair. has a 3'-5' helicase activity in presence of ATP. preferred substrate being one with both single and double stranded regions of DNA; ATP-dependent DNA helicase II UvrD1 5587462 uvrD1 6228838 uvrD1 Mycobacterium marinum M ATP-dependent DNA helicase II UvrD1 YP_001852814.1 5585153 R 216594 CDS YP_001852815.1 183984524 6228839 complement(5587543..5589549) 1 NC_010612.1 PPE family protein 5589549 6228839 MMAR_4554 Mycobacterium marinum M PPE family protein YP_001852815.1 5587543 R 216594 CDS YP_001852816.1 183984525 6228840 5589940..5590254 1 NC_010612.1 hypothetical protein 5590254 6228840 MMAR_4555 Mycobacterium marinum M hypothetical protein YP_001852816.1 5589940 D 216594 CDS YP_001852817.1 183984526 6228841 5590317..5591288 1 NC_010612.1 proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity; secreted antigen 85-C FbpC_2 5591288 fbpC_2 6228841 fbpC_2 Mycobacterium marinum M secreted antigen 85-C FbpC_2 YP_001852817.1 5590317 D 216594 CDS YP_001852818.1 183984527 6228842 5591331..5592995 1 NC_010612.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 5592995 pgi 6228842 pgi Mycobacterium marinum M glucose-6-phosphate isomerase YP_001852818.1 5591331 D 216594 CDS YP_001852819.1 183984528 6228843 complement(5593095..5593844) 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short chain dehydrogenase 5593844 6228843 MMAR_4558 Mycobacterium marinum M short chain dehydrogenase YP_001852819.1 5593095 R 216594 CDS YP_001852820.1 183984529 6228844 complement(5593933..5594796) 1 NC_010612.1 this enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents [catalytic activity: hydrolysis of DNA containing ring-opened N7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N- methyl)formamidopyrimide]; formamidopyrimidine-DNA glycosylase 5594796 6228844 MMAR_4559 Mycobacterium marinum M formamidopyrimidine-DNA glycosylase YP_001852820.1 5593933 R 216594 CDS YP_001852821.1 183984530 6228845 complement(5594844..5595905) 1 NC_010612.1 PE-PGRS family protein 5595905 6228845 MMAR_4560 Mycobacterium marinum M PE-PGRS family protein YP_001852821.1 5594844 R 216594 CDS YP_001852822.1 183984531 6228846 complement(5596024..5597733) 1 NC_010612.1 PE-PGRS family protein 5597733 6228846 MMAR_4561 Mycobacterium marinum M PE-PGRS family protein YP_001852822.1 5596024 R 216594 CDS YP_001852823.1 183984532 6228847 complement(5597809..5599524) 1 NC_010612.1 PE-PGRS family protein 5599524 6228847 MMAR_4562 Mycobacterium marinum M PE-PGRS family protein YP_001852823.1 5597809 R 216594 CDS YP_001852824.1 183984533 6228848 complement(5599695..5600438) 1 NC_010612.1 catalyzes the formation of precorrin 6x from precorrin 5; precorrin 6A synthase 5600438 6228848 MMAR_4563 Mycobacterium marinum M precorrin 6A synthase YP_001852824.1 5599695 R 216594 CDS YP_001852825.1 183984534 6228849 5600594..5601499 1 NC_010612.1 hypothetical protein 5601499 6228849 MMAR_4564 Mycobacterium marinum M hypothetical protein YP_001852825.1 5600594 D 216594 CDS YP_001852826.1 183984535 6228850 5601496..5602800 1 NC_010612.1 function unknown, probably involved in cellular metabolism; monooxygenase 5602800 6228850 MMAR_4565 Mycobacterium marinum M monooxygenase YP_001852826.1 5601496 D 216594 CDS YP_001852827.1 183984536 6228851 5603357..5604121 1 NC_010612.1 hypothetical protein 5604121 6228851 MMAR_4567 Mycobacterium marinum M hypothetical protein YP_001852827.1 5603357 D 216594 CDS YP_001852828.1 183984537 6228852 5604266..5605135 1 NC_010612.1 function unknown; probably involved in cellular metabolism; oxidoreductase 5605135 6228852 MMAR_4568 Mycobacterium marinum M oxidoreductase YP_001852828.1 5604266 D 216594 CDS YP_001852829.1 183984538 6228853 complement(5605139..5605945) 1 NC_010612.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA12_2 5605945 echA12_2 6228853 echA12_2 Mycobacterium marinum M enoyl-CoA hydratase, EchA12_2 YP_001852829.1 5605139 R 216594 CDS YP_001852830.1 183984539 6228854 5606026..5606949 1 NC_010612.1 hypothetical protein 5606949 6228854 MMAR_4570 Mycobacterium marinum M hypothetical protein YP_001852830.1 5606026 D 216594 CDS YP_001852831.1 183984540 6228855 5607069..5608880 1 NC_010612.1 PE-PGRS family protein 5608880 6228855 MMAR_4571 Mycobacterium marinum M PE-PGRS family protein YP_001852831.1 5607069 D 216594 CDS YP_001852832.1 183984541 6228856 complement(5608885..5610816) 1 NC_010612.1 function unknown; probably involved in cellular metabolism, possibly in a degradation pathway; bifunctional enzyme: 2-hydroxyhepta-2,4-diene- 1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase 5610816 6228856 MMAR_4572 Mycobacterium marinum M bifunctional enzyme: 2-hydroxyhepta-2,4-diene- 1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase YP_001852832.1 5608885 R 216594 CDS YP_001852833.1 183984542 6228857 complement(5610813..5613125) 1 NC_010612.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity; ATP-dependent DNA ligase 5613125 6228857 MMAR_4573 Mycobacterium marinum M ATP-dependent DNA ligase YP_001852833.1 5610813 R 216594 CDS YP_001852834.1 183984543 6228858 5613148..5614059 1 NC_010612.1 ATP + D-fructose = ADP + D-fructose 6-phosphate; fructokinase, PfkB 5614059 pfkB 6228858 pfkB Mycobacterium marinum M fructokinase, PfkB YP_001852834.1 5613148 D 216594 CDS YP_001852835.1 183984544 6228859 5614231..5615106 1 NC_010612.1 hypothetical protein 5615106 6228859 MMAR_4575 Mycobacterium marinum M hypothetical protein YP_001852835.1 5614231 D 216594 CDS YP_001852836.1 183984545 6228860 5615161..5616279 1 NC_010612.1 involved in active transport of inorganic phosphate across the membrane (import). this is one of the proteins required for binding-protein-mediated phosphate transport; periplasmic phosphate-binding lipoprotein PstS2 5616279 pstS2 6228860 pstS2 Mycobacterium marinum M periplasmic phosphate-binding lipoprotein PstS2 YP_001852836.1 5615161 D 216594 CDS YP_001852837.1 183984546 6228861 5616600..5618696 1 NC_010612.1 involved in signal transduction (via phosphorylation). thought to regulate phosphate transport. can phosphorylate the peptide substrate myelin basic protein (MBP) at serine and threonine residues. can be autophosphorylated on threonine residues [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; Ser/Thr protein kinase 5618696 pknD 6228861 pknD Mycobacterium marinum M Ser/Thr protein kinase YP_001852837.1 5616600 D 216594 CDS YP_001852838.1 183984547 6228862 complement(5618704..5619606) 1 NC_010612.1 involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport; phosphate-transport integral membrane ABC transporter PstA1 5619606 pstA1 6228862 pstA1 Mycobacterium marinum M phosphate-transport integral membrane ABC transporter PstA1 YP_001852838.1 5618704 R 216594 CDS YP_001852839.1 183984548 6228863 complement(5619603..5620577) 1 NC_010612.1 involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport; phosphate-transport integral membrane ABC transporter PstC2 5620577 pstC2 6228863 pstC2 Mycobacterium marinum M phosphate-transport integral membrane ABC transporter PstC2 YP_001852839.1 5619603 R 216594 CDS YP_001852840.1 183984549 6228864 complement(5620590..5621702) 1 NC_010612.1 involved in active transport of inorganic phosphate across the membrane (import). this is one of the proteins required for binding-protein-mediated phosphate transport; periplasmic phosphate-binding lipoprotein PhoS2 5621702 phoS2 6228864 phoS2 Mycobacterium marinum M periplasmic phosphate-binding lipoprotein PhoS2 YP_001852840.1 5620590 R 216594 CDS YP_001852841.1 183984550 6228865 5622036..5622827 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short chain dehydrogenase 5622827 6228865 MMAR_4581 Mycobacterium marinum M short chain dehydrogenase YP_001852841.1 5622036 D 216594 CDS YP_001852842.1 183984551 6228866 5622853..5623941 1 NC_010612.1 hypothetical protein 5623941 6228866 MMAR_4582 Mycobacterium marinum M hypothetical protein YP_001852842.1 5622853 D 216594 CDS YP_001852843.1 183984552 6228867 5624053..5624787 1 NC_010612.1 hypothetical protein 5624787 6228867 MMAR_4583 Mycobacterium marinum M hypothetical protein YP_001852843.1 5624053 D 216594 CDS YP_001852844.1 183984553 6228868 5624867..5626093 1 NC_010612.1 H(+)-stimulated, highly selective, divalent cation uptake system. responsible for the translocation of the divalent metal across the membrane; manganese transport protein MntH 5626093 mntH 6228868 mntH Mycobacterium marinum M manganese transport protein MntH YP_001852844.1 5624867 D 216594 CDS YP_001852845.1 183984554 6228869 5626259..5626588 1 NC_010612.1 hypothetical protein 5626588 6228869 MMAR_4585 Mycobacterium marinum M hypothetical protein YP_001852845.1 5626259 D 216594 CDS YP_001852846.1 183984555 6228870 5626705..5627766 1 NC_010612.1 hypothetical protein 5627766 6228870 MMAR_4586 Mycobacterium marinum M hypothetical protein YP_001852846.1 5626705 D 216594 CDS YP_001852847.1 183984556 6228871 5627794..5628612 1 NC_010612.1 oxidoreductase 5628612 6228871 MMAR_4587 Mycobacterium marinum M oxidoreductase YP_001852847.1 5627794 D 216594 CDS YP_001852848.1 183984557 6228873 5628794..5629075 1 NC_010612.1 hypothetical protein 5629075 6228873 MMAR_4588 Mycobacterium marinum M hypothetical protein YP_001852848.1 5628794 D 216594 CDS YP_001852849.1 183984558 6228874 5629088..5630521 1 NC_010612.1 hypothetical protein 5630521 6228874 MMAR_4589 Mycobacterium marinum M hypothetical protein YP_001852849.1 5629088 D 216594 CDS YP_001852850.1 183984559 6228875 5630702..5631331 1 NC_010612.1 hypothetical protein 5631331 6228875 MMAR_4590 Mycobacterium marinum M hypothetical protein YP_001852850.1 5630702 D 216594 CDS YP_001852851.1 183984560 6228876 5631328..5631747 1 NC_010612.1 hypothetical protein 5631747 6228876 MMAR_4591 Mycobacterium marinum M hypothetical protein YP_001852851.1 5631328 D 216594 CDS YP_001852852.1 183984561 6228877 complement(5632646..5633002) 1 NC_010612.1 single copy element. N-term subunit only hence element probably not functional; transposition of an insertion sequence element; transposase 5633002 6228877 MMAR_4592 Mycobacterium marinum M transposase YP_001852852.1 5632646 R 216594 CDS YP_001852853.1 183984562 6228879 complement(5633945..5634241) 1 NC_010612.1 single copy element; transposition of an insertion sequence; transposase 5634241 6228879 MMAR_4595 Mycobacterium marinum M transposase YP_001852853.1 5633945 R 216594 CDS YP_001852854.1 183984563 6228880 complement(5634468..5635451) 1 NC_010612.1 hypothetical protein 5635451 6228880 MMAR_4596 Mycobacterium marinum M hypothetical protein YP_001852854.1 5634468 R 216594 CDS YP_001852855.1 183984564 6228881 complement(5635456..5635914) 1 NC_010612.1 hypothetical protein 5635914 6228881 MMAR_4597 Mycobacterium marinum M hypothetical protein YP_001852855.1 5635456 R 216594 CDS YP_001852856.1 183984565 6228882 5636548..5636829 1 NC_010612.1 transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa1 5636829 6228882 MMAR_4598 Mycobacterium marinum M transposase, ISMyma01_aa1 YP_001852856.1 5636548 D 216594 CDS YP_001852857.1 183984566 6228883 5636871..5637665 1 NC_010612.1 transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa2 5637665 6228883 MMAR_4599 Mycobacterium marinum M transposase, ISMyma01_aa2 YP_001852857.1 5636871 D 216594 CDS YP_001852858.1 183984567 6228884 complement(5637976..5638149) 1 NC_010612.1 hypothetical protein 5638149 6228884 MMAR_4600 Mycobacterium marinum M hypothetical protein YP_001852858.1 5637976 R 216594 CDS YP_001852859.1 183984568 6228885 complement(5638306..5639169) 1 NC_010612.1 hypothetical protein 5639169 6228885 MMAR_4601 Mycobacterium marinum M hypothetical protein YP_001852859.1 5638306 R 216594 CDS YP_001852860.1 183984569 6228886 complement(5639613..5643368) 1 NC_010612.1 PE-PGRS family protein 5643368 6228886 MMAR_4602 Mycobacterium marinum M PE-PGRS family protein YP_001852860.1 5639613 R 216594 CDS YP_001852861.1 183984570 6228887 complement(5643353..5643865) 1 NC_010612.1 hypothetical protein 5643865 6228887 MMAR_4603 Mycobacterium marinum M hypothetical protein YP_001852861.1 5643353 R 216594 CDS YP_001852862.1 183984571 6228888 5643939..5644520 1 NC_010612.1 single copy element; transposition of an insertion sequence. possibly IS200 family; transposase 5644520 6228888 MMAR_4604 Mycobacterium marinum M transposase YP_001852862.1 5643939 D 216594 CDS YP_001852863.1 183984572 6228889 complement(5644363..5644866) 1 NC_010612.1 hypothetical protein 5644866 6228889 MMAR_4605 Mycobacterium marinum M hypothetical protein YP_001852863.1 5644363 R 216594 CDS YP_001852864.1 183984573 6228890 complement(5645143..5646444) 1 NC_010612.1 PPE family protein 5646444 6228890 MMAR_4606 Mycobacterium marinum M PPE family protein YP_001852864.1 5645143 R 216594 CDS YP_001852865.1 183984574 6228891 5647310..5648161 1 NC_010612.1 hypothetical protein 5648161 6228891 MMAR_4607 Mycobacterium marinum M hypothetical protein YP_001852865.1 5647310 D 216594 CDS YP_001852866.1 183984575 6228892 5648434..5648667 1 NC_010612.1 hypothetical protein 5648667 6228892 MMAR_4608 Mycobacterium marinum M hypothetical protein YP_001852866.1 5648434 D 216594 CDS YP_001852867.1 183984576 6228893 5648933..5649427 1 NC_010612.1 hypothetical protein 5649427 6228893 MMAR_4609 Mycobacterium marinum M hypothetical protein YP_001852867.1 5648933 D 216594 CDS YP_001852868.1 183984577 6228894 5650087..5650887 1 NC_010612.1 hypothetical protein 5650887 6228894 MMAR_4610 Mycobacterium marinum M hypothetical protein YP_001852868.1 5650087 D 216594 CDS YP_001852869.1 183984578 6228895 5651201..5651500 1 NC_010612.1 PE family protein 5651500 6228895 MMAR_4611 Mycobacterium marinum M PE family protein YP_001852869.1 5651201 D 216594 CDS YP_001852870.1 183984579 6228896 5651509..5652777 1 NC_010612.1 function unknown. possibly a protective antigen involved with the early control of infection; PPE family protein 5652777 6228896 MMAR_4612 Mycobacterium marinum M PPE family protein YP_001852870.1 5651509 D 216594 CDS YP_001852871.1 183984580 6228897 5653031..5654266 1 NC_010612.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 5654266 6228897 MMAR_4613 Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001852871.1 5653031 D 216594 CDS YP_001852872.1 183984581 6228898 5654268..5655788 1 NC_010612.1 function unknown, probably involved in cellular metabolism; dioxygenase 5655788 6228898 MMAR_4614 Mycobacterium marinum M dioxygenase YP_001852872.1 5654268 D 216594 CDS YP_001852873.1 183984582 6228899 5655805..5656278 1 NC_010612.1 hypothetical protein 5656278 6228899 MMAR_4615 Mycobacterium marinum M hypothetical protein YP_001852873.1 5655805 D 216594 CDS YP_001852874.1 183984583 6228900 complement(5656284..5656718) 1 NC_010612.1 hypothetical protein 5656718 6228900 MMAR_4616 Mycobacterium marinum M hypothetical protein YP_001852874.1 5656284 R 216594 CDS YP_001852875.1 183984584 6228901 complement(5656789..5657562) 1 NC_010612.1 hypothetical protein 5657562 6228901 MMAR_4617 Mycobacterium marinum M hypothetical protein YP_001852875.1 5656789 R 216594 CDS YP_001852876.1 183984585 6228902 5657728..5658981 1 NC_010612.1 hypothetical protein 5658981 6228902 MMAR_4618 Mycobacterium marinum M hypothetical protein YP_001852876.1 5657728 D 216594 CDS YP_001852877.1 183984586 6228903 complement(5659093..5659539) 1 NC_010612.1 hypothetical protein 5659539 6228903 MMAR_4619 Mycobacterium marinum M hypothetical protein YP_001852877.1 5659093 R 216594 CDS YP_001852878.1 183984587 6228904 complement(5659544..5659732) 1 NC_010612.1 hypothetical protein 5659732 6228904 MMAR_4620 Mycobacterium marinum M hypothetical protein YP_001852878.1 5659544 R 216594 CDS YP_001852879.1 183984588 6228905 complement(5659834..5668854) 1 NC_010612.1 PPE family protein 5668854 6228905 MMAR_4621 Mycobacterium marinum M PPE family protein YP_001852879.1 5659834 R 216594 CDS YP_001852880.1 183984589 6228906 complement(5669219..5671594) 1 NC_010612.1 metal cation-transporting ATPase; possibly catalyzes the transport of undeterminated metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undeterminated metal cation(in) = ADP + phosphate + undeterminated metal cation(out)]; metal cation transporter ATPase p-type CtpE 5671594 ctpE 6228906 ctpE Mycobacterium marinum M metal cation transporter ATPase p-type CtpE YP_001852880.1 5669219 R 216594 CDS YP_001852881.1 183984590 6228907 complement(5671591..5673174) 1 NC_010612.1 function unknown, possibly involved in cell wall biosynthesis; penicillin binding protein 5673174 6228907 MMAR_4623 Mycobacterium marinum M penicillin binding protein YP_001852881.1 5671591 R 216594 CDS YP_001852882.1 183984591 6228908 complement(5673413..5674531) 1 NC_010612.1 hypothetical protein 5674531 6228908 MMAR_4624 Mycobacterium marinum M hypothetical protein YP_001852882.1 5673413 R 216594 CDS YP_001852883.1 183984592 6228909 complement(5674538..5675269) 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 5675269 echA6 6228909 echA6 Mycobacterium marinum M enoyl-CoA hydratase YP_001852883.1 5674538 R 216594 CDS YP_001852884.1 183984593 6228910 5675296..5676777 1 NC_010612.1 this protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [catalytic activity ATP + acetyl-CoA + HCO(3)(- ) = ADP + phosphate + malonyl-CoA]; acetyl-CoA carboxylase carboxyl transferase subunit beta 5676777 accD3 6228910 accD3 Mycobacterium marinum M acetyl-CoA carboxylase carboxyl transferase subunit beta YP_001852884.1 5675296 D 216594 CDS YP_001852885.1 183984594 6228911 5677825..5679270 1 NC_010612.1 C-term truncated 20aa.; function unknown, but maybe involved in efflux system (probably sugar or drug transport); hypothetical protein 5679270 6228911 MMAR_4627 Mycobacterium marinum M hypothetical protein YP_001852885.1 5677825 D 216594 CDS YP_001852886.1 183984595 6228912 5679252..5680607 1 NC_010612.1 could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase 5680607 bioF2_1 6228912 bioF2_1 Mycobacterium marinum M 8-amino-7-oxononanoate synthase YP_001852886.1 5679252 D 216594 CDS YP_001852887.1 183984596 6228913 5680819..5681763 1 NC_010612.1 involved in cysteine biosynthesis [catalytic activity : O3-acetyl-L-serine + H(2)S = L-cysteine + acetate]; cysteine synthase B 5681763 cysM 6228913 cysM Mycobacterium marinum M cysteine synthase B YP_001852887.1 5680819 D 216594 CDS YP_001852888.1 183984597 6228914 5682008..5682949 1 NC_010612.1 involved in lipid desaturation; membrane-bound C-5 sterol desaturase 5682949 erg3_1 6228914 erg3_1 Mycobacterium marinum M membrane-bound C-5 sterol desaturase YP_001852888.1 5682008 D 216594 CDS YP_001852889.1 183984598 6228915 complement(5683008..5683619) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 5683619 6228915 MMAR_4631 Mycobacterium marinum M transcriptional regulatory protein YP_001852889.1 5683008 R 216594 CDS YP_001852890.1 183984599 6228916 5683718..5685388 1 NC_010612.1 proposed role in polysaccahride synthesis; putative FAD-binding dehydrogenase 5685388 6228916 MMAR_4632 Mycobacterium marinum M putative FAD-binding dehydrogenase YP_001852890.1 5683718 D 216594 CDS YP_001852891.1 183984600 6228917 5685539..5686249 1 NC_010612.1 transcriptional regulator part of the two-component regulatory system PrrA/PrrB. thought to be involved in the environmental adaptation , specifically in an early phase of the intracellular growth; two-component response transcriptional regulatory protein PrrA 5686249 prrA 6228917 prrA Mycobacterium marinum M two-component response transcriptional regulatory protein PrrA YP_001852891.1 5685539 D 216594 CDS YP_001852892.1 183984601 6228918 5686255..5687604 1 NC_010612.1 sensor part of the two-component regulatory system PrrA/PrrB. thought to be involved in the environmental adaptation , specifically in an early phase of the intracellular growth; two-component sensor histidine kinase PrrB 5687604 prrB 6228918 prrB Mycobacterium marinum M two-component sensor histidine kinase PrrB YP_001852892.1 5686255 D 216594 CDS YP_001852893.1 183984602 6228919 complement(5687624..5688262) 1 NC_010612.1 exported or membrane protein 5688262 6228919 MMAR_4635 Mycobacterium marinum M exported or membrane protein YP_001852893.1 5687624 R 216594 CDS YP_001852894.1 183984603 6228920 complement(5688262..5688495) 1 NC_010612.1 hypothetical protein 5688495 6228920 MMAR_4636 Mycobacterium marinum M hypothetical protein YP_001852894.1 5688262 R 216594 CDS YP_001852895.1 183984604 6228921 complement(5688508..5689506) 1 NC_010612.1 the protein behaved as a porin of low specific activity. structural protein that may protect the integrity of the bacterium; outer membrane protein OmpA 5689506 ompA 6228921 ompA Mycobacterium marinum M outer membrane protein OmpA YP_001852895.1 5688508 R 216594 CDS YP_001852896.1 183984605 6228922 5689618..5689881 1 NC_010612.1 hypothetical protein 5689881 6228922 MMAR_4638 Mycobacterium marinum M hypothetical protein YP_001852896.1 5689618 D 216594 CDS YP_001852897.1 183984606 6228923 5689905..5691479 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 5691479 6228923 MMAR_4639 Mycobacterium marinum M oxidoreductase YP_001852897.1 5689905 D 216594 CDS YP_001852898.1 183984607 6228924 complement(5691484..5692779) 1 NC_010612.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 5692779 gltA 6228924 gltA Mycobacterium marinum M type II citrate synthase YP_001852898.1 5691484 R 216594 CDS YP_001852899.1 183984608 6228925 complement(5693167..5694636) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; monooxygenase 5694636 6228925 MMAR_4641 Mycobacterium marinum M monooxygenase YP_001852899.1 5693167 R 216594 CDS YP_001852900.1 183984609 6228926 complement(5694900..5695559) 1 NC_010612.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 5695559 pdxH 6228926 pdxH Mycobacterium marinum M pyridoxamine 5'-phosphate oxidase YP_001852900.1 5694900 R 216594 CDS YP_001852901.1 183984610 6228927 5695630..5696751 1 NC_010612.1 forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; citrate synthase 2 5696751 citA 6228927 citA Mycobacterium marinum M citrate synthase 2 YP_001852901.1 5695630 D 216594 CDS YP_001852902.1 183984611 6228928 complement(5696801..5698351) 1 NC_010612.1 hypothetical protein 5698351 6228928 MMAR_4644 Mycobacterium marinum M hypothetical protein YP_001852902.1 5696801 R 216594 CDS YP_001852903.1 183984612 6228929 5699795..5700253 1 NC_010612.1 hypothetical protein 5700253 6228929 MMAR_4645 Mycobacterium marinum M hypothetical protein YP_001852903.1 5699795 D 216594 CDS YP_001852904.1 183984613 6228930 complement(5700330..5702015) 1 NC_010612.1 serves as the first electron transfer protein in all the P450 systems [catalytic activity: reduced adrenodoxin + NADP+ = oxidized adrenodoxin + NADPH]; NADPH:adrenodoxin oxidoreductase FprB 5702015 fprB 6228930 fprB Mycobacterium marinum M NADPH:adrenodoxin oxidoreductase FprB YP_001852904.1 5700330 R 216594 CDS YP_001852905.1 183984614 6228931 complement(5702034..5703059) 1 NC_010612.1 hypothetical protein 5703059 6228931 MMAR_4647 Mycobacterium marinum M hypothetical protein YP_001852905.1 5702034 R 216594 CDS YP_001852906.1 183984615 6228932 5703266..5704396 1 NC_010612.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 5704396 serC 6228932 serC Mycobacterium marinum M phosphoserine aminotransferase YP_001852906.1 5703266 D 216594 CDS YP_001852907.1 183984616 6228933 5704518..5705309 1 NC_010612.1 hypothetical protein 5705309 6228933 MMAR_4649 Mycobacterium marinum M hypothetical protein YP_001852907.1 5704518 D 216594 CDS YP_001852908.1 183984617 6228934 complement(5705306..5705593) 1 NC_010612.1 transmembrane protein 5705593 6228934 MMAR_4650 Mycobacterium marinum M transmembrane protein YP_001852908.1 5705306 R 216594 CDS YP_001852909.1 183984618 6228935 complement(5705590..5706429) 1 NC_010612.1 causes methylation; rRNA methyltransferase 5706429 6228935 MMAR_4651 Mycobacterium marinum M rRNA methyltransferase YP_001852909.1 5705590 R 216594 CDS YP_001852910.1 183984619 6228936 complement(5706426..5706713) 1 NC_010612.1 thought to be involved in transcriptional mechanism; MarR family transcriptional regulator 5706713 6228936 MMAR_4652 Mycobacterium marinum M MarR family transcriptional regulator YP_001852910.1 5706426 R 216594 CDS YP_001852911.1 183984620 6228937 5707116..5707403 1 NC_010612.1 transmembrane protein 5707403 6228937 MMAR_4653 Mycobacterium marinum M transmembrane protein YP_001852911.1 5707116 D 216594 CDS YP_001852912.1 183984621 6228938 5707424..5707879 1 NC_010612.1 hypothetical protein 5707879 6228938 MMAR_4654 Mycobacterium marinum M hypothetical protein YP_001852912.1 5707424 D 216594 CDS YP_001852913.1 183984622 6228939 complement(5707876..5708679) 1 NC_010612.1 hypothetical protein 5708679 6228939 MMAR_4655 Mycobacterium marinum M hypothetical protein YP_001852913.1 5707876 R 216594 CDS YP_001852914.1 183984623 6228940 5708785..5710494 1 NC_010612.1 transmembrane protein 5710494 6228940 MMAR_4656 Mycobacterium marinum M transmembrane protein YP_001852914.1 5708785 D 216594 CDS YP_001852915.1 183984624 6228941 5710491..5710979 1 NC_010612.1 hypothetical protein 5710979 6228941 MMAR_4657 Mycobacterium marinum M hypothetical protein YP_001852915.1 5710491 D 216594 CDS YP_001852916.1 183984625 6228942 5711088..5711942 1 NC_010612.1 hypothetical protein 5711942 6228942 MMAR_4658 Mycobacterium marinum M hypothetical protein YP_001852916.1 5711088 D 216594 CDS YP_001852917.1 183984626 6228943 complement(5711939..5712943) 1 NC_010612.1 hypothetical protein 5712943 6228943 MMAR_4659 Mycobacterium marinum M hypothetical protein YP_001852917.1 5711939 R 216594 CDS YP_001852918.1 183984627 6228944 complement(5712956..5714908) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE10 5714908 fadE10 6228944 fadE10 Mycobacterium marinum M acyl-CoA dehydrogenase FadE10 YP_001852918.1 5712956 R 216594 CDS YP_001852919.1 183984628 6228945 complement(5715096..5715500) 1 NC_010612.1 function unknown; thought to act in response to low temperature; cold shock-like protein B CspB 5715500 cspB 6228945 cspB Mycobacterium marinum M cold shock-like protein B CspB YP_001852919.1 5715096 R 216594 CDS YP_001852920.1 183984629 6228946 5715664..5716068 1 NC_010612.1 hypothetical protein 5716068 6228946 MMAR_4662 Mycobacterium marinum M hypothetical protein YP_001852920.1 5715664 D 216594 CDS YP_001852921.1 183984630 6228947 5716065..5717147 1 NC_010612.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 5717147 moaA 6228947 moaA Mycobacterium marinum M molybdenum cofactor biosynthesis protein A YP_001852921.1 5716065 D 216594 CDS YP_001852922.1 183984631 6228948 5717161..5717430 1 NC_010612.1 involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein D 2 MoaD2 5717430 moaD2 6228948 moaD2 Mycobacterium marinum M molybdenum cofactor biosynthesis protein D 2 MoaD2 YP_001852922.1 5717161 D 216594 CDS YP_001852923.1 183984632 6228949 5717866..5719023 1 NC_010612.1 function unknown. may be promote the resuscitation and growth of dormant, nongrowing cell; resuscitation-promoting factor RpfA 5719023 rpfA 6228949 rpfA Mycobacterium marinum M resuscitation-promoting factor RpfA YP_001852923.1 5717866 D 216594 CDS YP_001852924.1 183984633 6228950 complement(5719068..5719493) 1 NC_010612.1 possibly a molybdenum biosynthesis cofactor. conversion of molybdopterin precursor Z into molybdopterin requires transfer of two sulfur atoms to precursor Z (to generate the dithiolene group). this is catalyzed by the converting factor composed of a small and large subunit; molybdenum cofactor biosynthesis protein E2 MoaE2 5719493 moaE2 6228950 moaE2 Mycobacterium marinum M molybdenum cofactor biosynthesis protein E2 MoaE2 YP_001852924.1 5719068 R 216594 CDS YP_001852925.1 183984634 6228951 complement(5719490..5719975) 1 NC_010612.1 involved in molybdopterin biosynthesis; involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes; molybdopterin biosynthesis Mog protein 5719975 mog 6228951 mog Mycobacterium marinum M molybdopterin biosynthesis Mog protein YP_001852925.1 5719490 R 216594 CDS YP_001852926.1 183984635 6228952 complement(5719972..5720508) 1 NC_010612.1 involved in the biosynthesis of molybdopterin; molybdenum cofactor biosynthesis protein C 2 MoaC2 5720508 moaC2 6228952 moaC2 Mycobacterium marinum M molybdenum cofactor biosynthesis protein C 2 MoaC2 YP_001852926.1 5719972 R 216594 CDS YP_001852927.1 183984636 6228953 complement(5720517..5720726) 1 NC_010612.1 hypothetical protein 5720726 6228953 MMAR_4669 Mycobacterium marinum M hypothetical protein YP_001852927.1 5720517 R 216594 CDS YP_001852928.1 183984637 6228954 5720789..5723047 1 NC_010612.1 hypothetical protein 5723047 6228954 MMAR_4670 Mycobacterium marinum M hypothetical protein YP_001852928.1 5720789 D 216594 CDS YP_001852929.1 183984638 6228955 5723130..5724779 1 NC_010612.1 involved in nucleotide excision repair. has helicase activity: acts by opening DNA either around the RNA transcription start site or the DNA damage; DNA helicase Ercc3 5724779 ercc3 6228955 ercc3 Mycobacterium marinum M DNA helicase Ercc3 YP_001852929.1 5723130 D 216594 CDS YP_001852930.1 183984639 6228956 complement(5724891..5725328) 1 NC_010612.1 hypothetical protein 5725328 6228956 MMAR_5545 Mycobacterium marinum M hypothetical protein YP_001852930.1 5724891 R 216594 CDS YP_001852931.1 183984640 6228957 5725630..5725950 1 NC_010612.1 hypothetical protein 5725950 6228957 MMAR_4672 Mycobacterium marinum M hypothetical protein YP_001852931.1 5725630 D 216594 CDS YP_001852932.1 183984641 6228958 complement(5725977..5726960) 1 NC_010612.1 function unknown, may have reductase activity; hypothetical protein 5726960 6228958 MMAR_4673 Mycobacterium marinum M hypothetical protein YP_001852932.1 5725977 R 216594 CDS YP_001852933.1 183984642 6228959 complement(5727030..5727566) 1 NC_010612.1 transcriptional regulator 5727566 6228959 MMAR_4674 Mycobacterium marinum M transcriptional regulator YP_001852933.1 5727030 R 216594 CDS YP_001852934.1 183984643 6228960 5727646..5728857 1 NC_010612.1 membrane-associated oxidoreductase 5728857 6228960 MMAR_4675 Mycobacterium marinum M membrane-associated oxidoreductase YP_001852934.1 5727646 D 216594 CDS YP_001852935.1 183984644 6228961 complement(5728932..5731076) 1 NC_010612.1 involved in fatty acid degradation (probably in fatty acid beta-oxidation cycle); fatty oxidation protein FadB 5731076 fadB 6228961 fadB Mycobacterium marinum M fatty oxidation protein FadB YP_001852935.1 5728932 R 216594 CDS YP_001852936.1 183984645 6228962 complement(5731081..5732334) 1 NC_010612.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 5732334 fadA 6228962 fadA Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001852936.1 5731081 R 216594 CDS YP_001852937.1 183984646 6228963 5732496..5733692 1 NC_010612.1 function unknown, probably involved in cellular metabolism; aminotransferase 5733692 6228963 MMAR_4678 Mycobacterium marinum M aminotransferase YP_001852937.1 5732496 D 216594 CDS YP_001852938.1 183984647 6228964 complement(5733689..5734150) 1 NC_010612.1 hypothetical protein 5734150 6228964 MMAR_4679 Mycobacterium marinum M hypothetical protein YP_001852938.1 5733689 R 216594 CDS YP_001852939.1 183984648 6228965 complement(5734176..5734640) 1 NC_010612.1 hypothetical protein 5734640 6228965 MMAR_4680 Mycobacterium marinum M hypothetical protein YP_001852939.1 5734176 R 216594 CDS YP_001852940.1 183984649 6228966 complement(5734690..5735769) 1 NC_010612.1 function unknown, but involvement in lipid degradation (racemization); fatty-acid-CoA racemase Far 5735769 far 6228966 far Mycobacterium marinum M fatty-acid-CoA racemase Far YP_001852940.1 5734690 R 216594 CDS YP_001852941.1 183984650 6228967 complement(5735779..5736219) 1 NC_010612.1 conserved hypothetical protein; hypothetical protein 5736219 6228967 MMAR_4682 Mycobacterium marinum M hypothetical protein YP_001852941.1 5735779 R 216594 CDS YP_001852942.1 183984651 6228968 5736283..5737983 1 NC_010612.1 possible indole-3-pyruvate decarboxylase; [catalytic activity: 3-(indol-3-YL) pyruvate = 2-(indol-3- YL)acetaldehyde + CO2], or possible pyruvate decarboxylase; [catalytic activity: a 2-OXO acid = an aldehyde + CO2]; pyruvate or indole-3-pyruvate decarboxylase Pdc 5737983 pdc 6228968 pdc Mycobacterium marinum M pyruvate or indole-3-pyruvate decarboxylase Pdc YP_001852942.1 5736283 D 216594 CDS YP_001852943.1 183984652 6228969 complement(5737998..5738183) 1 NC_010612.1 conserved hypothetical protein; hypothetical protein 5738183 6228969 MMAR_4684 Mycobacterium marinum M hypothetical protein YP_001852943.1 5737998 R 216594 CDS YP_001852944.1 183984653 6228970 complement(5738197..5738826) 1 NC_010612.1 function unknown, but involved in lipid degradation; fatty-acid-CoA ligase FadD16 5738826 fadD16 6228970 fadD16 Mycobacterium marinum M fatty-acid-CoA ligase FadD16 YP_001852944.1 5738197 R 216594 CDS YP_001852945.1 183984654 6228971 complement(5738878..5739459) 1 NC_010612.1 hypothetical protein 5739459 6228971 MMAR_4686 Mycobacterium marinum M hypothetical protein YP_001852945.1 5738878 R 216594 CDS YP_001852946.1 183984655 6228972 complement(5739456..5740439) 1 NC_010612.1 hypothetical protein 5740439 6228972 MMAR_4687 Mycobacterium marinum M hypothetical protein YP_001852946.1 5739456 R 216594 CDS YP_001852947.1 183984656 6228973 complement(5740712..5742151) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 5742151 fadD3_2 6228973 fadD3_2 Mycobacterium marinum M long-chain-fatty-acid--CoA ligase YP_001852947.1 5740712 R 216594 CDS YP_001852948.1 183984657 6228974 complement(5742148..5743329) 1 NC_010612.1 function unknown, contains a hydrolytic domain; hypothetical protein 5743329 6228974 MMAR_4689 Mycobacterium marinum M hypothetical protein YP_001852948.1 5742148 R 216594 CDS YP_001852949.1 183984658 6228975 complement(5743423..5743845) 1 NC_010612.1 lipoprotein 5743845 6228975 MMAR_4690 Mycobacterium marinum M lipoprotein YP_001852949.1 5743423 R 216594 CDS YP_001852950.1 183984659 6228976 5743989..5744753 1 NC_010612.1 oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA8_2 5744753 echA8_2 6228976 echA8_2 Mycobacterium marinum M enoyl-CoA hydratase, EchA8_2 YP_001852950.1 5743989 D 216594 CDS YP_001852951.1 183984660 6228977 5744750..5745181 1 NC_010612.1 hypothetical protein 5745181 6228977 MMAR_4692 Mycobacterium marinum M hypothetical protein YP_001852951.1 5744750 D 216594 CDS YP_001852952.1 183984661 6228978 complement(5745184..5745768) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulator 5745768 6228978 MMAR_4693 Mycobacterium marinum M transcriptional regulator YP_001852952.1 5745184 R 216594 CDS YP_001852953.1 183984662 6228979 5745928..5747202 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 150A6 Cyp150A6 5747202 cyp150A6 6228979 cyp150A6 Mycobacterium marinum M cytochrome P450 150A6 Cyp150A6 YP_001852953.1 5745928 D 216594 CDS YP_001852954.1 183984663 6228980 complement(5747221..5747511) 1 NC_010612.1 hypothetical protein 5747511 6228980 MMAR_4695 Mycobacterium marinum M hypothetical protein YP_001852954.1 5747221 R 216594 CDS YP_001852955.1 183984664 6228981 complement(5747515..5748120) 1 NC_010612.1 function unknown role in electron transport; cytochrome C oxidase subunit III 5748120 6228981 MMAR_4696 Mycobacterium marinum M cytochrome C oxidase subunit III YP_001852955.1 5747515 R 216594 CDS YP_001852956.1 183984665 6228982 complement(5748117..5748929) 1 NC_010612.1 hypothetical protein 5748929 6228982 MMAR_4697 Mycobacterium marinum M hypothetical protein YP_001852956.1 5748117 R 216594 CDS YP_001852957.1 183984666 6228983 complement(5748932..5749681) 1 NC_010612.1 hypothetical protein 5749681 6228983 MMAR_4698 Mycobacterium marinum M hypothetical protein YP_001852957.1 5748932 R 216594 CDS YP_001852958.1 183984667 6228984 5749769..5750350 1 NC_010612.1 transcriptional regulatory protein 5750350 6228984 MMAR_4699 Mycobacterium marinum M transcriptional regulatory protein YP_001852958.1 5749769 D 216594 CDS YP_001852959.1 183984668 6228985 5750550..5750840 1 NC_010612.1 hypothetical protein 5750840 6228985 MMAR_4700 Mycobacterium marinum M hypothetical protein YP_001852959.1 5750550 D 216594 CDS YP_001852960.1 183984669 6228986 complement(5750867..5751283) 1 NC_010612.1 hypothetical protein 5751283 6228986 MMAR_4701 Mycobacterium marinum M hypothetical protein YP_001852960.1 5750867 R 216594 CDS YP_001852961.1 183984670 6228987 5751435..5752169 1 NC_010612.1 hypothetical protein 5752169 6228987 MMAR_4702 Mycobacterium marinum M hypothetical protein YP_001852961.1 5751435 D 216594 CDS YP_001852962.1 183984671 6228988 5752166..5752696 1 NC_010612.1 hypothetical protein 5752696 6228988 MMAR_4703 Mycobacterium marinum M hypothetical protein YP_001852962.1 5752166 D 216594 CDS YP_001852963.1 183984672 6228989 5752798..5753301 1 NC_010612.1 hypothetical protein 5753301 6228989 MMAR_4704 Mycobacterium marinum M hypothetical protein YP_001852963.1 5752798 D 216594 CDS YP_001852964.1 183984673 6228990 complement(5753337..5754968) 1 NC_010612.1 function unknown, but thought involved in host cell invasion; MCE-family protein 5754968 6228990 MMAR_4705 Mycobacterium marinum M MCE-family protein YP_001852964.1 5753337 R 216594 CDS YP_001852965.1 183984674 6228991 complement(5754969..5756201) 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE family lipoprotein 5756201 6228991 MMAR_4706 Mycobacterium marinum M MCE family lipoprotein YP_001852965.1 5754969 R 216594 CDS YP_001852966.1 183984675 6228992 complement(5756198..5757625) 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein 5757625 6228992 MMAR_4707 Mycobacterium marinum M MCE-family protein YP_001852966.1 5756198 R 216594 CDS YP_001852967.1 183984676 6228993 complement(5757622..5758704) 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein 5758704 6228993 MMAR_4708 Mycobacterium marinum M MCE-family protein YP_001852967.1 5757622 R 216594 CDS YP_001852968.1 183984677 6228994 complement(5758697..5759728) 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein 5759728 6228994 MMAR_4709 Mycobacterium marinum M MCE-family protein YP_001852968.1 5758697 R 216594 CDS YP_001852969.1 183984678 6228995 complement(5759725..5761002) 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein 5761002 6228995 MMAR_4710 Mycobacterium marinum M MCE-family protein YP_001852969.1 5759725 R 216594 CDS YP_001852970.1 183984679 6228996 complement(5761022..5761867) 1 NC_010612.1 hypothetical protein 5761867 6228996 MMAR_4711 Mycobacterium marinum M hypothetical protein YP_001852970.1 5761022 R 216594 CDS YP_001852971.1 183984680 6228997 complement(5761910..5762716) 1 NC_010612.1 hypothetical protein 5762716 6228997 MMAR_4712 Mycobacterium marinum M hypothetical protein YP_001852971.1 5761910 R 216594 CDS YP_001852972.1 183984681 6228998 complement(5763034..5764239) 1 NC_010612.1 dehydratase 5764239 6228998 MMAR_4713 Mycobacterium marinum M dehydratase YP_001852972.1 5763034 R 216594 CDS YP_001852973.1 183984682 6228999 complement(5764236..5765780) 1 NC_010612.1 oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; NAD-dependent aldehyde dehydrogenase 5765780 6228999 MMAR_4714 Mycobacterium marinum M NAD-dependent aldehyde dehydrogenase YP_001852973.1 5764236 R 216594 CDS YP_001852974.1 183984683 6229000 5766071..5766772 1 NC_010612.1 involved in the fatty acid biosynthesis [catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH]; 3-oxoacyl-ACP reductase 5766772 6229000 MMAR_4715 Mycobacterium marinum M 3-oxoacyl-ACP reductase YP_001852974.1 5766071 D 216594 CDS YP_001852975.1 183984684 6229001 5766881..5767081 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin 5767081 6229001 MMAR_4716 Mycobacterium marinum M ferredoxin YP_001852975.1 5766881 D 216594 CDS YP_001852976.1 183984685 6229002 5767096..5768460 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 188A3 Cyp188A3 5768460 cyp188A3 6229002 cyp188A3 Mycobacterium marinum M cytochrome P450 188A3 Cyp188A3 YP_001852976.1 5767096 D 216594 CDS YP_001852977.1 183984686 6229003 complement(5768561..5769736) 1 NC_010612.1 function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase 5769736 6229003 MMAR_4718 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001852977.1 5768561 R 216594 CDS YP_001852978.1 183984687 6229004 complement(5769720..5770718) 1 NC_010612.1 function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase 5770718 6229004 MMAR_4719 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001852978.1 5769720 R 216594 CDS YP_001852979.1 183984688 6229005 5770820..5771320 1 NC_010612.1 hypothetical protein 5771320 6229005 MMAR_4720 Mycobacterium marinum M hypothetical protein YP_001852979.1 5770820 D 216594 CDS YP_001852980.1 183984689 6229006 complement(5771483..5772097) 1 NC_010612.1 function unknown; probably involved in cellular metabolism; nitroreductase 5772097 6229006 MMAR_4721 Mycobacterium marinum M nitroreductase YP_001852980.1 5771483 R 216594 CDS YP_001852981.1 183984690 6229007 5772382..5773938 1 NC_010612.1 hydrolyzes sphingomyelin in addition to phosphatidylcholine. probable virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [catalytic activity: a phosphatidylcholine + H(2)O = 1,2- diacylglycerol + choline phosphate]; membrane-associated phospholipase C2 PlcB 5773938 plcB_6 6229007 plcB_6 Mycobacterium marinum M membrane-associated phospholipase C2 PlcB YP_001852981.1 5772382 D 216594 CDS YP_001852982.1 183984691 6229008 5774113..5774580 1 NC_010612.1 hypothetical protein 5774580 6229008 MMAR_4723 Mycobacterium marinum M hypothetical protein YP_001852982.1 5774113 D 216594 CDS YP_001852983.1 183984692 6229009 5774873..5775976 1 NC_010612.1 metal-dependent hydrolase 5775976 6229009 MMAR_4724 Mycobacterium marinum M metal-dependent hydrolase YP_001852983.1 5774873 D 216594 CDS YP_001852984.1 183984693 6229010 5776024..5777169 1 NC_010612.1 metal-dependent hydrolase 5777169 6229010 MMAR_4725 Mycobacterium marinum M metal-dependent hydrolase YP_001852984.1 5776024 D 216594 CDS YP_001852985.1 183984694 6229011 5777171..5777563 1 NC_010612.1 could as ferredoxin subunits of nitrite reductase; hypothetical protein 5777563 6229011 MMAR_4726 Mycobacterium marinum M hypothetical protein YP_001852985.1 5777171 D 216594 CDS YP_001852986.1 183984695 6229012 5777560..5778447 1 NC_010612.1 hydrolase 5778447 6229012 MMAR_4727 Mycobacterium marinum M hydrolase YP_001852986.1 5777560 D 216594 CDS YP_001852987.1 183984696 6229013 complement(5778462..5778935) 1 NC_010612.1 hypothetical protein 5778935 6229013 MMAR_4728 Mycobacterium marinum M hypothetical protein YP_001852987.1 5778462 R 216594 CDS YP_001852988.1 183984697 6229014 5778988..5780325 1 NC_010612.1 involved in aerobic|anaerobic respiration [catalytic activity: NADH + ubiquinone = NAD(+) + ubiquinol]; NADH dehydrogenase I subunit F 5780325 nuoF_1 6229014 nuoF_1 Mycobacterium marinum M NADH dehydrogenase I subunit F YP_001852988.1 5778988 D 216594 CDS YP_001852989.1 183984698 6229015 5780322..5780618 1 NC_010612.1 required for electron transfer; ferredoxin 5780618 6229015 MMAR_4730 Mycobacterium marinum M ferredoxin YP_001852989.1 5780322 D 216594 CDS YP_001852990.1 183984699 6229016 5780754..5782409 1 NC_010612.1 function unknown, supposed involvement in lipid metabolism. may have specificity for branched-chain acyl CoAs; 3-ketoacyl-CoA thiolase 5782409 6229016 MMAR_4731 Mycobacterium marinum M 3-ketoacyl-CoA thiolase YP_001852990.1 5780754 D 216594 CDS YP_001852991.1 183984700 6229017 5782406..5783308 1 NC_010612.1 ensuring efficient processing by acyl-synthase machinery E.G. PKS; thioesterase 5783308 6229017 MMAR_4732 Mycobacterium marinum M thioesterase YP_001852991.1 5782406 D 216594 CDS YP_001852992.1 183984701 6229018 5783436..5784638 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 190A3 Cyp190A3 5784638 cyp190A3 6229018 cyp190A3 Mycobacterium marinum M cytochrome P450 190A3 Cyp190A3 YP_001852992.1 5783436 D 216594 CDS YP_001852993.1 183984702 6229019 5784649..5784840 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin FdxD 5784840 fdxD_2 6229019 fdxD_2 Mycobacterium marinum M ferredoxin FdxD YP_001852993.1 5784649 D 216594 CDS YP_001852994.1 183984703 6229020 5785047..5786729 1 NC_010612.1 PE-PGRS family protein 5786729 6229020 MMAR_4735 Mycobacterium marinum M PE-PGRS family protein YP_001852994.1 5785047 D 216594 CDS YP_001852995.1 183984704 6229021 complement(5786777..5786965) 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin 5786965 6229021 MMAR_4736 Mycobacterium marinum M ferredoxin YP_001852995.1 5786777 R 216594 CDS YP_001852996.1 183984705 6229022 complement(5786962..5788233) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 150A5 Cyp150A5 5788233 cyp150A5 6229022 cyp150A5 Mycobacterium marinum M cytochrome P450 150A5 Cyp150A5 YP_001852996.1 5786962 R 216594 CDS YP_001852997.1 183984706 6229023 complement(5788342..5788845) 1 NC_010612.1 hypothetical protein 5788845 6229023 MMAR_4738 Mycobacterium marinum M hypothetical protein YP_001852997.1 5788342 R 216594 CDS YP_001852998.1 183984707 6229024 complement(5788842..5789447) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 5789447 6229024 MMAR_4739 Mycobacterium marinum M TetR family transcriptional regulator YP_001852998.1 5788842 R 216594 CDS YP_001852999.1 183984708 6229025 complement(5789551..5790711) 1 NC_010612.1 function unknown, but involved in lipid degradation [catalytic activity: 2 acetyl-CoA = CoA + acetoacetyl- CoA]; acetyl-CoA acetyltransferase 5790711 fadA6_2 6229025 fadA6_2 Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001852999.1 5789551 R 216594 CDS YP_001853000.1 183984709 6229026 complement(5790807..5791973) 1 NC_010612.1 function unknown, but involved in lipid metabolism; acyl-CoA dehydrogenase FadE12 5791973 fadE12_1 6229026 fadE12_1 Mycobacterium marinum M acyl-CoA dehydrogenase FadE12 YP_001853000.1 5790807 R 216594 CDS YP_001853001.1 183984710 6229027 complement(5792084..5793382) 1 NC_010612.1 function unknown role in cellular metabolism; metal-dependent amidohydrolase 5793382 6229027 MMAR_4742 Mycobacterium marinum M metal-dependent amidohydrolase YP_001853001.1 5792084 R 216594 CDS YP_001853002.1 183984711 6229028 5793711..5794259 1 NC_010612.1 hypothetical protein 5794259 6229028 MMAR_4743 Mycobacterium marinum M hypothetical protein YP_001853002.1 5793711 D 216594 CDS YP_001853003.1 183984712 6229029 5794267..5795547 1 NC_010612.1 function unknown; involved in cellular metabolism; dioxygenase 5795547 6229029 MMAR_4744 Mycobacterium marinum M dioxygenase YP_001853003.1 5794267 D 216594 CDS YP_001853004.1 183984713 6229030 5795531..5795866 1 NC_010612.1 hypothetical protein 5795866 6229030 MMAR_4745 Mycobacterium marinum M hypothetical protein YP_001853004.1 5795531 D 216594 CDS YP_001853005.1 183984714 6229031 5795870..5797090 1 NC_010612.1 imidazolonepropionase is an amidohydrolase; imidazolonepropionase 5797090 6229031 MMAR_4746 Mycobacterium marinum M imidazolonepropionase YP_001853005.1 5795870 D 216594 CDS YP_001853006.1 183984715 6229032 5797074..5797493 1 NC_010612.1 hypothetical protein 5797493 6229032 MMAR_4747 Mycobacterium marinum M hypothetical protein YP_001853006.1 5797074 D 216594 CDS YP_001853007.1 183984716 6229033 5797490..5798599 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 5798599 6229033 MMAR_4748 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001853007.1 5797490 D 216594 CDS YP_001853008.1 183984717 6229034 5798620..5799438 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase 5799438 6229034 MMAR_4749 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001853008.1 5798620 D 216594 CDS YP_001853009.1 183984718 6229035 complement(5799569..5801041) 1 NC_010612.1 function unknown, possibly involved in transport of sulfate across the membrane; integral membrane transporter 5801041 6229035 MMAR_4750 Mycobacterium marinum M integral membrane transporter YP_001853009.1 5799569 R 216594 CDS YP_001853010.1 183984719 6229036 complement(5801405..5802592) 1 NC_010612.1 function unknown, but supposed involvement in lipid degradation; acyl-CoA dehydrogenase 5802592 6229036 MMAR_4751 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001853010.1 5801405 R 216594 CDS YP_001853011.1 183984720 6229037 5802783..5803436 1 NC_010612.1 could be involved in transcriptional mechanism; transcriptional regulatory protein 5803436 6229037 MMAR_4752 Mycobacterium marinum M transcriptional regulatory protein YP_001853011.1 5802783 D 216594 CDS YP_001853012.1 183984721 6229038 5803670..5804872 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 189A7 Cyp189A7 5804872 cyp189A7 6229038 cyp189A7 Mycobacterium marinum M cytochrome P450 189A7 Cyp189A7 YP_001853012.1 5803670 D 216594 CDS YP_001853013.1 183984722 6229039 5804903..5805754 1 NC_010612.1 function unknown; possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 5805754 6229039 MMAR_4754 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001853013.1 5804903 D 216594 CDS YP_001853014.1 183984723 6229040 5805766..5806596 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short chain dehydrogenase 5806596 6229040 MMAR_4755 Mycobacterium marinum M short chain dehydrogenase YP_001853014.1 5805766 D 216594 CDS YP_001853015.1 183984724 6229041 complement(5806593..5807399) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 5807399 6229041 MMAR_4756 Mycobacterium marinum M oxidoreductase YP_001853015.1 5806593 R 216594 CDS YP_001853016.1 183984725 6229042 complement(5807408..5809846) 1 NC_010612.1 acyl-CoA transferase 5809846 6229042 MMAR_4757 Mycobacterium marinum M acyl-CoA transferase YP_001853016.1 5807408 R 216594 CDS YP_001853017.1 183984726 6229043 complement(5809846..5810838) 1 NC_010612.1 oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA4 5810838 echA4_1 6229043 echA4_1 Mycobacterium marinum M enoyl-CoA hydratase, EchA4 YP_001853017.1 5809846 R 216594 CDS YP_001853018.1 183984727 6229044 complement(5810841..5811959) 1 NC_010612.1 function unknown, hydrolyses peptides; aminopeptidase 5811959 6229044 MMAR_4759 Mycobacterium marinum M aminopeptidase YP_001853018.1 5810841 R 216594 CDS YP_001853019.1 183984728 6229045 complement(5811949..5813184) 1 NC_010612.1 hydrolysis of peptide bonds; dipeptidase 5813184 6229045 MMAR_4760 Mycobacterium marinum M dipeptidase YP_001853019.1 5811949 R 216594 CDS YP_001853020.1 183984729 6229046 complement(5813194..5814366) 1 NC_010612.1 hypothetical protein 5814366 6229046 MMAR_4761 Mycobacterium marinum M hypothetical protein YP_001853020.1 5813194 R 216594 CDS YP_001853021.1 183984730 6229047 complement(5814404..5815648) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 105Q4 Cyp105Q4 5815648 cyp105Q4 6229047 cyp105Q4 Mycobacterium marinum M cytochrome P450 105Q4 Cyp105Q4 YP_001853021.1 5814404 R 216594 CDS YP_001853022.1 183984731 6229048 complement(5815651..5815845) 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin 5815845 6229048 MMAR_4763 Mycobacterium marinum M ferredoxin YP_001853022.1 5815651 R 216594 CDS YP_001853023.1 183984732 6229049 complement(5815858..5816523) 1 NC_010612.1 function unknown, maybe a transcriptional regulator; hypothetical protein 5816523 6229049 MMAR_4764 Mycobacterium marinum M hypothetical protein YP_001853023.1 5815858 R 216594 CDS YP_001853024.1 183984733 6229050 complement(5816612..5817415) 1 NC_010612.1 short chain dehydrogenase 5817415 6229050 MMAR_4765 Mycobacterium marinum M short chain dehydrogenase YP_001853024.1 5816612 R 216594 CDS YP_001853025.1 183984734 6229051 5817610..5818362 1 NC_010612.1 function unknown; domain homology to nucleoside- diphosphate-sugar epimerases; hypothetical protein 5818362 6229051 MMAR_4766 Mycobacterium marinum M hypothetical protein YP_001853025.1 5817610 D 216594 CDS YP_001853026.1 183984735 6229052 complement(5818415..5819692) 1 NC_010612.1 thought to be involved in transport of undeterminated substrate (possibly drug) across the membrane. responsible for the translocation of the substrate across the membrane; integral membrane transport protein 5819692 6229052 MMAR_4767 Mycobacterium marinum M integral membrane transport protein YP_001853026.1 5818415 R 216594 CDS YP_001853027.1 183984736 6229053 complement(5819692..5820912) 1 NC_010612.1 thought to be involved in cysteine biosynthesis [catalytic activity: O3-acetyl-L-serine + H(2)S = L- cysteine + acetate]; cysteine synthase a CysK2 5820912 cysK2 6229053 cysK2 Mycobacterium marinum M cysteine synthase a CysK2 YP_001853027.1 5819692 R 216594 CDS YP_001853028.1 183984737 6229054 complement(5821016..5821432) 1 NC_010612.1 lipoprotein LpqS 5821432 lpqS 6229054 lpqS Mycobacterium marinum M lipoprotein LpqS YP_001853028.1 5821016 R 216594 CDS YP_001853029.1 183984738 6229055 5821553..5823211 1 NC_010612.1 probable oxidase, showing similarity with several oxidases, mainly L-ascorbate oxidases and copper resistance proteins; oxidase 5823211 6229055 MMAR_4770 Mycobacterium marinum M oxidase YP_001853029.1 5821553 D 216594 CDS YP_001853030.1 183984739 6229056 complement(5823242..5824060) 1 NC_010612.1 function unknown, predicted hydrolase or acyltransferase domain; hypothetical protein 5824060 6229056 MMAR_4771 Mycobacterium marinum M hypothetical protein YP_001853030.1 5823242 R 216594 CDS YP_001853031.1 183984740 6229057 complement(5824060..5825049) 1 NC_010612.1 putative cyclase; hypothetical protein 5825049 6229057 MMAR_4772 Mycobacterium marinum M hypothetical protein YP_001853031.1 5824060 R 216594 CDS YP_001853032.1 183984741 6229058 complement(5825049..5825864) 1 NC_010612.1 catalyzes the formation of 5-alpha-androstane-3,17-dione from androsterone; Acts on other 3-alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin.; 3-alpha-hydroxysteroid dehydrogenase 5825864 6229058 MMAR_4773 Mycobacterium marinum M 3-alpha-hydroxysteroid dehydrogenase YP_001853032.1 5825049 R 216594 CDS YP_001853033.1 183984742 6229059 complement(5825899..5827200) 1 NC_010612.1 monoxygenase 5827200 6229059 MMAR_4774 Mycobacterium marinum M monoxygenase YP_001853033.1 5825899 R 216594 CDS YP_001853034.1 183984743 6229060 complement(5827203..5828957) 1 NC_010612.1 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione; 3-ketosteroid-delta-1-dehydrogenase 5828957 6229060 MMAR_4775 Mycobacterium marinum M 3-ketosteroid-delta-1-dehydrogenase YP_001853034.1 5827203 R 216594 CDS YP_001853035.1 183984744 6229061 complement(5828954..5829874) 1 NC_010612.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 5829874 mhpB 6229061 mhpB Mycobacterium marinum M 3-(2,3-dihydroxyphenyl)propionate dioxygenase YP_001853035.1 5828954 R 216594 CDS YP_001853036.1 183984745 6229062 complement(5829822..5831537) 1 NC_010612.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 5831537 mhpA 6229062 mhpA Mycobacterium marinum M 3-(3-hydroxyphenyl)propionate hydroxylase YP_001853036.1 5829822 R 216594 CDS YP_001853037.1 183984746 6229063 complement(5831537..5832403) 1 NC_010612.1 involved in the degradation of biphenyl; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase 5832403 bphD_1 6229063 bphD_1 Mycobacterium marinum M 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase YP_001853037.1 5831537 R 216594 CDS YP_001853038.1 183984747 6229064 5832532..5833209 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 5833209 6229064 MMAR_4779 Mycobacterium marinum M transcriptional regulatory protein YP_001853038.1 5832532 D 216594 CDS YP_001853039.1 183984748 6229065 5833224..5834837 1 NC_010612.1 dehydrogenase 5834837 6229065 MMAR_4780 Mycobacterium marinum M dehydrogenase YP_001853039.1 5833224 D 216594 CDS YP_001853040.1 183984749 6229066 complement(5834844..5836061) 1 NC_010612.1 possible sensor part of a two-component regulatory system; two-component sensor kinase 5836061 6229066 MMAR_4781 Mycobacterium marinum M two-component sensor kinase YP_001853040.1 5834844 R 216594 CDS YP_001853041.1 183984750 6229067 5836286..5836936 1 NC_010612.1 nitrate/nitrite response regulator protein NarL 5836936 narL 6229067 narL Mycobacterium marinum M nitrate/nitrite response regulator protein NarL YP_001853041.1 5836286 D 216594 CDS YP_001853042.1 183984751 6229068 complement(5836881..5838422) 1 NC_010612.1 possible sensor part of a two-component regulatory system; two-component sensor kinase 5838422 6229068 MMAR_4783 Mycobacterium marinum M two-component sensor kinase YP_001853042.1 5836881 R 216594 CDS YP_001853043.1 183984752 6229069 complement(5838406..5839320) 1 NC_010612.1 dehydrogenase 5839320 6229069 MMAR_4784 Mycobacterium marinum M dehydrogenase YP_001853043.1 5838406 R 216594 CDS YP_001853044.1 183984753 6229070 complement(5839552..5840865) 1 NC_010612.1 integral membrane protein 5840865 6229070 MMAR_4785 Mycobacterium marinum M integral membrane protein YP_001853044.1 5839552 R 216594 CDS YP_001853045.1 183984754 6229071 complement(5841215..5841514) 1 NC_010612.1 PE-PGRS family protein 5841514 6229071 MMAR_4786 Mycobacterium marinum M PE-PGRS family protein YP_001853045.1 5841215 R 216594 CDS YP_001853046.1 183984755 6229072 complement(5841603..5842481) 1 NC_010612.1 transport system kinase - possibly arginine; transport system kinase 5842481 6229072 MMAR_4787 Mycobacterium marinum M transport system kinase YP_001853046.1 5841603 R 216594 CDS YP_001853047.1 183984756 6229073 complement(5842499..5843650) 1 NC_010612.1 function unknown but may be involved in fatty acid oxidation (beta oxidation); beta-ketoacyl CoA thiolase 5843650 6229073 MMAR_4788 Mycobacterium marinum M beta-ketoacyl CoA thiolase YP_001853047.1 5842499 R 216594 CDS YP_001853048.1 183984757 6229074 5843765..5844631 1 NC_010612.1 specifically catalyzes the removal of N-terminal proline residues from peptides. thought to release the N- terminal proline from the dipeptides, pro-pro, pro-gln, pro-trp and pro-tyr; also from amides (pro-beta na) and oligopeptides, pro-leu-glynH2, pro-leu-gly and pro-phe-gly- lys. higher activity toward small peptides (up to three residues), but very low activity for longer peptides [catalytic activity: release of a N-terminal proline from a peptide]; proline iminopeptidase Pip 5844631 pip 6229074 pip Mycobacterium marinum M proline iminopeptidase Pip YP_001853048.1 5843765 D 216594 CDS YP_001853049.1 183984758 6229075 complement(5844660..5845427) 1 NC_010612.1 lipid metabolism; enoyl-CoA hydratase 5845427 6229075 MMAR_4790 Mycobacterium marinum M enoyl-CoA hydratase YP_001853049.1 5844660 R 216594 CDS YP_001853050.1 183984759 6229076 complement(5845429..5846526) 1 NC_010612.1 involved in lipid metabolism; acyl-CoA dehydrogenase 5846526 6229076 MMAR_4791 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001853050.1 5845429 R 216594 CDS YP_001853051.1 183984760 6229077 complement(5846513..5847418) 1 NC_010612.1 involved in lipid metabolism; acyl-CoA dehydrogenase 5847418 6229077 MMAR_4792 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001853051.1 5846513 R 216594 CDS YP_001853052.1 183984761 6229078 complement(5847396..5848799) 1 NC_010612.1 acyl-CoA synthetase 5848799 6229078 MMAR_4793 Mycobacterium marinum M acyl-CoA synthetase YP_001853052.1 5847396 R 216594 CDS YP_001853053.1 183984762 6229079 5848915..5849196 1 NC_010612.1 similar to ferredoxin reductase electron transfer proteins; electron transfer protein 5849196 6229079 MMAR_4794 Mycobacterium marinum M electron transfer protein YP_001853053.1 5848915 D 216594 CDS YP_001853054.1 183984763 6229080 complement(5849226..5850266) 1 NC_010612.1 acyl-CoA transferase 5850266 6229080 MMAR_4795 Mycobacterium marinum M acyl-CoA transferase YP_001853054.1 5849226 R 216594 CDS YP_001853055.1 183984764 6229081 complement(5850263..5851219) 1 NC_010612.1 oxidoreductase 5851219 6229081 MMAR_4796 Mycobacterium marinum M oxidoreductase YP_001853055.1 5850263 R 216594 CDS YP_001853056.1 183984765 6229082 complement(5851204..5851641) 1 NC_010612.1 involved in propionic acid fermentation. catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid- cycle intermediates [catalytic activity : (R)-2-methyl-3- oxopropanoyl-CoA = succinyl- CoA.]; methylmalonyl-CoA mutase subunit alpha, McmA2b 5851641 mcmA2b 6229082 mcmA2b Mycobacterium marinum M methylmalonyl-CoA mutase subunit alpha, McmA2b YP_001853056.1 5851204 R 216594 CDS YP_001853057.1 183984766 6229083 complement(5851642..5853219) 1 NC_010612.1 catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [catalytic activity : (R)-2-methyl-3-oxopropanoyl-CoA = succinyl- CoA.]. the enzyme methylmalonyl-CoA mutase is a member of a class of enzymes that uses coenzyme B12 (adenosylcobalamin) as a cofactor. the enzyme induces the formation of an adenosyl radical from the cofactor. this radical then initiates a free-radical rearrangement of its substrate, succinyl-CoA, to methylmalonyl-CoA; methylmalonyl-CoA mutase beta subunit, McmA2a 5853219 mcmA2a 6229083 mcmA2a Mycobacterium marinum M methylmalonyl-CoA mutase beta subunit, McmA2a YP_001853057.1 5851642 R 216594 CDS YP_001853058.1 183984767 6229084 complement(5853344..5854156) 1 NC_010612.1 possible methylase; hypothetical protein 5854156 6229084 MMAR_4799 Mycobacterium marinum M hypothetical protein YP_001853058.1 5853344 R 216594 CDS YP_001853059.1 183984768 6229085 complement(5854217..5855002) 1 NC_010612.1 lipoprotein LpqR 5855002 lpqR 6229085 lpqR Mycobacterium marinum M lipoprotein LpqR YP_001853059.1 5854217 R 216594 CDS YP_001853060.1 183984769 6229086 5855113..5855703 1 NC_010612.1 hypothetical protein 5855703 6229086 MMAR_4801 Mycobacterium marinum M hypothetical protein YP_001853060.1 5855113 D 216594 CDS YP_001853061.1 183984770 6229087 5855725..5856579 1 NC_010612.1 contains a N-term cellobiohydrolase a (1,4-beta- cellobiosidase a) domain and a C-term cellulose-binding domain (CBD) domain. the CBD is found either at the N-term or at the C-terminal extremity of endoglucanases, cellobiohydrolases (exoglucanases), or xylanases; chitinase/cellulase 5856579 6229087 MMAR_4802 Mycobacterium marinum M chitinase/cellulase YP_001853061.1 5855725 D 216594 CDS YP_001853062.1 183984771 6229088 complement(5856598..5856888) 1 NC_010612.1 transmembrane protein; hypothetical protein 5856888 6229088 MMAR_4803 Mycobacterium marinum M hypothetical protein YP_001853062.1 5856598 R 216594 CDS YP_001853063.1 183984772 6229089 complement(5856885..5857190) 1 NC_010612.1 function unknown; possible role in carotenoid pigment biosynthesis given linkage to CrtI and CrtB; hypothetical protein 5857190 6229089 MMAR_4804 Mycobacterium marinum M hypothetical protein YP_001853063.1 5856885 R 216594 CDS YP_001853064.1 183984773 6229090 5857600..5858754 1 NC_010612.1 converts farensyl pyrophosphate to geranylgeranyl pyrophosphate, the latter being the substrate for CrtB in the production of phytoene during carotenoid synthesis; geranylgeranyl pyrophosphate synthase 5858754 crtE 6229090 crtE Mycobacterium marinum M geranylgeranyl pyrophosphate synthase YP_001853064.1 5857600 D 216594 CDS YP_001853065.1 183984774 6229091 5858779..5860308 1 NC_010612.1 part of carotenoid biosynthesis cluster; phytoene dehydrogenase CrtI 5860308 crtI 6229091 crtI Mycobacterium marinum M phytoene dehydrogenase CrtI YP_001853065.1 5858779 D 216594 CDS YP_001853066.1 183984775 6229092 5860305..5861264 1 NC_010612.1 part of carotenoid biosynthesis cluster - photochromogenesis; phytoene synthase, CrtB 5861264 crtB 6229092 crtB Mycobacterium marinum M phytoene synthase, CrtB YP_001853066.1 5860305 D 216594 CDS YP_001853067.1 183984776 6229093 5861261..5861584 1 NC_010612.1 involved in carotenoid biosynthesis; lycopene cyclase, CrtYc 5861584 crtYc 6229093 crtYc Mycobacterium marinum M lycopene cyclase, CrtYc YP_001853067.1 5861261 D 216594 CDS YP_001853068.1 183984777 6229094 5861581..5861955 1 NC_010612.1 involved in carotenoid biosynthesis; lycopene cyclase, CrtYd 5861955 crtYd 6229094 crtYd Mycobacterium marinum M lycopene cyclase, CrtYd YP_001853068.1 5861581 D 216594 CDS YP_001853069.1 183984778 6229095 5861949..5864258 1 NC_010612.1 function unknown. thought to be involved in fatty acid transport; transmembrane transport protein MmpL 5864258 mmpL13_1 6229095 mmpL13_1 Mycobacterium marinum M transmembrane transport protein MmpL YP_001853069.1 5861949 D 216594 CDS YP_001853070.1 183984779 6229096 5864308..5864859 1 NC_010612.1 involved in transcriptional mechanism; MarR family transcriptional regulator 5864859 6229096 MMAR_4811 Mycobacterium marinum M MarR family transcriptional regulator YP_001853070.1 5864308 D 216594 CDS YP_001853071.1 183984780 6229097 complement(5864869..5865915) 1 NC_010612.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 5865915 idi2 6229097 idi2 Mycobacterium marinum M isopentenyl pyrophosphate isomerase YP_001853071.1 5864869 R 216594 CDS YP_001853072.1 183984781 6229098 complement(5866032..5866739) 1 NC_010612.1 hypothetical protein 5866739 6229098 MMAR_4813 Mycobacterium marinum M hypothetical protein YP_001853072.1 5866032 R 216594 CDS YP_001853073.1 183984782 6229099 complement(5866733..5867335) 1 NC_010612.1 hypothetical protein 5867335 6229099 MMAR_4814 Mycobacterium marinum M hypothetical protein YP_001853073.1 5866733 R 216594 CDS YP_001853074.1 183984783 6229100 complement(5867417..5868901) 1 NC_010612.1 involved in L-asparagine transport; L-asparagine permease AnsP1 5868901 ansP1 6229100 ansP1 Mycobacterium marinum M L-asparagine permease AnsP1 YP_001853074.1 5867417 R 216594 CDS YP_001853075.1 183984784 6229101 complement(5868945..5869187) 1 NC_010612.1 hypothetical protein 5869187 6229101 MMAR_4816 Mycobacterium marinum M hypothetical protein YP_001853075.1 5868945 R 216594 CDS YP_001853076.1 183984785 6229102 complement(5869377..5869937) 1 NC_010612.1 function unknown, predicted ATPase domain; hypothetical protein 5869937 6229102 MMAR_4817 Mycobacterium marinum M hypothetical protein YP_001853076.1 5869377 R 216594 CDS YP_001853077.1 183984786 6229103 5870113..5871063 1 NC_010612.1 probable dehydrogenase; hypothetical protein 5871063 6229103 MMAR_4818 Mycobacterium marinum M hypothetical protein YP_001853077.1 5870113 D 216594 CDS YP_001853078.1 183984787 6229104 5871060..5871875 1 NC_010612.1 hypothetical protein 5871875 6229104 MMAR_4819 Mycobacterium marinum M hypothetical protein YP_001853078.1 5871060 D 216594 CDS YP_001853079.1 183984788 6229105 5871878..5873092 1 NC_010612.1 contains amidohydrolase domain; hypothetical protein 5873092 6229105 MMAR_4820 Mycobacterium marinum M hypothetical protein YP_001853079.1 5871878 D 216594 CDS YP_001853080.1 183984789 6229106 5873107..5874402 1 NC_010612.1 function unknown; contains amidohydrolase domain; hypothetical protein 5874402 6229106 MMAR_4821 Mycobacterium marinum M hypothetical protein YP_001853080.1 5873107 D 216594 CDS YP_001853081.1 183984790 6229107 5874700..5876571 1 NC_010612.1 PE-PGRS family protein 5876571 6229107 MMAR_4822 Mycobacterium marinum M PE-PGRS family protein YP_001853081.1 5874700 D 216594 CDS YP_001853082.1 183984791 6229108 complement(5876841..5877044) 1 NC_010612.1 possibly involved in cold acclimatization processes (the production of the protein is supposed predominantly induced at low temperatures); cold shock protein a, CspA 5877044 cspA 6229108 cspA Mycobacterium marinum M cold shock protein a, CspA YP_001853082.1 5876841 R 216594 CDS YP_001853083.1 183984792 6229109 complement(5877137..5878711) 1 NC_010612.1 function unknown, possibly involved in ATP- dependent RNA unwinding, enzymes of this class are needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation; ATP-dependent RNA helicase, RhlE1 5878711 rhlE1 6229109 rhlE1 Mycobacterium marinum M ATP-dependent RNA helicase, RhlE1 YP_001853083.1 5877137 R 216594 CDS YP_001853084.1 183984793 6229110 5878927..5879061 1 NC_010612.1 hypothetical protein 5879061 6229110 MMAR_5579 Mycobacterium marinum M hypothetical protein YP_001853084.1 5878927 D 216594 CDS YP_001853085.1 183984794 6229111 5879550..5883284 1 NC_010612.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 5883284 metH 6229111 metH Mycobacterium marinum M B12-dependent methionine synthase YP_001853085.1 5879550 D 216594 CDS YP_001853086.1 183984795 6229112 5883692..5884360 1 NC_010612.1 contains a nucleotidyltransferase domain; hypothetical protein 5884360 6229112 MMAR_4826 Mycobacterium marinum M hypothetical protein YP_001853086.1 5883692 D 216594 CDS YP_001853087.1 183984796 6229113 5884360..5884785 1 NC_010612.1 hypothetical protein 5884785 6229113 MMAR_4827 Mycobacterium marinum M hypothetical protein YP_001853087.1 5884360 D 216594 CDS YP_001853088.1 183984797 6229114 5885265..5886767 1 NC_010612.1 hypothetical protein 5886767 6229114 MMAR_4828 Mycobacterium marinum M hypothetical protein YP_001853088.1 5885265 D 216594 CDS YP_001853089.1 183984798 6229115 complement(5886746..5887186) 1 NC_010612.1 hypothetical protein 5887186 6229115 MMAR_4829 Mycobacterium marinum M hypothetical protein YP_001853089.1 5886746 R 216594 CDS YP_001853090.1 183984799 6229116 5887386..5888039 1 NC_010612.1 hypothetical protein 5888039 6229116 MMAR_4830 Mycobacterium marinum M hypothetical protein YP_001853090.1 5887386 D 216594 CDS YP_001853091.1 183984800 6229117 5888093..5888434 1 NC_010612.1 hypothetical protein 5888434 6229117 MMAR_4831 Mycobacterium marinum M hypothetical protein YP_001853091.1 5888093 D 216594 CDS YP_001853092.1 183984801 6229118 complement(5888860..5889441) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 5889441 6229118 MMAR_4832 Mycobacterium marinum M TetR family transcriptional regulator YP_001853092.1 5888860 R 216594 CDS YP_001853093.1 183984802 6229119 5889490..5890701 1 NC_010612.1 cytochrome P450s are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 123B1 Cyp123B1 5890701 cyp123B1 6229119 cyp123B1 Mycobacterium marinum M cytochrome P450 123B1 Cyp123B1 YP_001853093.1 5889490 D 216594 CDS YP_001853094.1 183984803 6229120 complement(5890714..5891400) 1 NC_010612.1 possibly involved in a transcriptional mechanism; TetR family transcriptional regulator 5891400 6229120 MMAR_4834 Mycobacterium marinum M TetR family transcriptional regulator YP_001853094.1 5890714 R 216594 CDS YP_001853095.1 183984804 6229121 5891628..5891957 1 NC_010612.1 hypothetical protein 5891957 6229121 MMAR_4835 Mycobacterium marinum M hypothetical protein YP_001853095.1 5891628 D 216594 CDS YP_001853096.1 183984805 6229122 5892201..5895269 1 NC_010612.1 thought to be involved in fatty acid transport; MmpL family transport protein 5895269 6229122 MMAR_4836 Mycobacterium marinum M MmpL family transport protein YP_001853096.1 5892201 D 216594 CDS YP_001853097.1 183984806 6229123 5895233..5896177 1 NC_010612.1 function unknown; hydrolase 5896177 6229123 MMAR_4837 Mycobacterium marinum M hydrolase YP_001853097.1 5895233 D 216594 CDS YP_001853098.1 183984807 6229124 complement(5896293..5896715) 1 NC_010612.1 hypothetical protein 5896715 6229124 MMAR_4838 Mycobacterium marinum M hypothetical protein YP_001853098.1 5896293 R 216594 CDS YP_001853099.1 183984808 6229125 complement(5896761..5897393) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 5897393 6229125 MMAR_4839 Mycobacterium marinum M TetR family transcriptional regulator YP_001853099.1 5896761 R 216594 CDS YP_001853100.1 183984809 6229126 5897637..5898377 1 NC_010612.1 involved in transcriptional mechanism; putative regulatory protein 5898377 6229126 MMAR_4840 Mycobacterium marinum M putative regulatory protein YP_001853100.1 5897637 D 216594 CDS YP_001853101.1 183984810 6229127 complement(5898448..5898876) 1 NC_010612.1 may be an ADP-ribose pyrophosphatase - involved DNA replication, recombination, and repair; hypothetical protein 5898876 6229127 MMAR_4841 Mycobacterium marinum M hypothetical protein YP_001853101.1 5898448 R 216594 CDS YP_001853102.1 183984811 6229128 5898954..5899748 1 NC_010612.1 involved in unknown transcriptional regulatory network; regulatory protein 5899748 6229128 MMAR_4842 Mycobacterium marinum M regulatory protein YP_001853102.1 5898954 D 216594 CDS YP_001853103.1 183984812 6229129 5899848..5900270 1 NC_010612.1 hypothetical protein 5900270 6229129 MMAR_4843 Mycobacterium marinum M hypothetical protein YP_001853103.1 5899848 D 216594 CDS YP_001853104.1 183984813 6229131 5901219..5901500 1 NC_010612.1 transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa1 5901500 6229131 MMAR_4845 Mycobacterium marinum M transposase, ISMyma01_aa1 YP_001853104.1 5901219 D 216594 CDS YP_001853105.1 183984814 6229132 5901542..5902336 1 NC_010612.1 transposition of the insertion sequence ISMyma01; transposase, ISMyma01_aa2 5902336 6229132 MMAR_4846 Mycobacterium marinum M transposase, ISMyma01_aa2 YP_001853105.1 5901542 D 216594 CDS YP_001853106.1 183984815 6229133 5902868..5903098 1 NC_010612.1 hypothetical protein 5903098 6229133 MMAR_4847 Mycobacterium marinum M hypothetical protein YP_001853106.1 5902868 D 216594 CDS YP_001853107.1 183984816 6229134 5903099..5904256 1 NC_010612.1 part of a prophage not present in M. ulcerans. however a highly related integrase is present in M. ulcerans; prophage integrase 5904256 6229134 MMAR_4848 Mycobacterium marinum M prophage integrase YP_001853107.1 5903099 D 216594 CDS YP_001853108.1 183984817 6229139 5904980..5905792 1 NC_010612.1 hypothetical protein 5905792 6229139 MMAR_4849 Mycobacterium marinum M hypothetical protein YP_001853108.1 5904980 D 216594 CDS YP_001853109.1 183984818 6229140 complement(5905810..5906715) 1 NC_010612.1 function unknown, may be involved in polyketide biosynthesis [secondary metabolites biosynthesis, transport, and catabolism]; O-methyltransferase 5906715 6229140 MMAR_4850 Mycobacterium marinum M O-methyltransferase YP_001853109.1 5905810 R 216594 CDS YP_001853110.1 183984819 6229141 5906809..5907309 1 NC_010612.1 domain homology to CumB, cytosine/adenosine deaminases; deaminase 5907309 6229141 MMAR_4851 Mycobacterium marinum M deaminase YP_001853110.1 5906809 D 216594 CDS YP_001853111.1 183984820 6229142 5907367..5907738 1 NC_010612.1 transcription regulator ArsR 5907738 6229142 MMAR_4852 Mycobacterium marinum M transcription regulator ArsR YP_001853111.1 5907367 D 216594 CDS YP_001853112.1 183984821 6229143 5907795..5907998 1 NC_010612.1 hypothetical protein 5907998 6229143 MMAR_4853 Mycobacterium marinum M hypothetical protein YP_001853112.1 5907795 D 216594 CDS YP_001853113.1 183984822 6229144 complement(5908011..5909069) 1 NC_010612.1 hypothetical protein 5909069 6229144 MMAR_4854 Mycobacterium marinum M hypothetical protein YP_001853113.1 5908011 R 216594 CDS YP_001853114.1 183984823 6229145 5909143..5909784 1 NC_010612.1 hypothetical protein 5909784 6229145 MMAR_4855 Mycobacterium marinum M hypothetical protein YP_001853114.1 5909143 D 216594 CDS YP_001853115.1 183984824 6229146 5909952..5910968 1 NC_010612.1 involved in mycolic acid biosynthesis; acyl-[acyl-carrier protein] desaturase DesA1 5910968 desA1 6229146 desA1 Mycobacterium marinum M acyl-[acyl-carrier protein] desaturase DesA1 YP_001853115.1 5909952 D 216594 CDS YP_001853116.1 183984825 6229147 5910977..5912110 1 NC_010612.1 domain homology - tRNA-dihydrouridine synthase [translation, ribosomal structure and biogenesis]; transcriptional regulator 5912110 6229147 MMAR_4857 Mycobacterium marinum M transcriptional regulator YP_001853116.1 5910977 D 216594 CDS YP_001853117.1 183984826 6229148 5912377..5914500 1 NC_010612.1 domain conservation - LytR, transcriptional regulator; hypothetical protein 5914500 6229148 MMAR_4858 Mycobacterium marinum M hypothetical protein YP_001853117.1 5912377 D 216594 CDS YP_001853118.1 183984827 6229149 5914558..5915226 1 NC_010612.1 involved in transcriptional regulation of active transport of inorganic phosphate across the membrane; phosphate-transport system regulatory protein, PhoY2 5915226 phoY2 6229149 phoY2 Mycobacterium marinum M phosphate-transport system regulatory protein, PhoY2 YP_001853118.1 5914558 D 216594 CDS YP_001853119.1 183984828 6229150 complement(5915262..5916038) 1 NC_010612.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 5916038 phoT 6229150 phoT Mycobacterium marinum M phosphate transporter ATP-binding protein YP_001853119.1 5915262 R 216594 CDS YP_001853120.1 183984829 6229151 complement(5916058..5916966) 1 NC_010612.1 involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport; phosphate-transport integral membrane ABC transporter, PstA 5916966 pstA 6229151 pstA Mycobacterium marinum M phosphate-transport integral membrane ABC transporter, PstA YP_001853120.1 5916058 R 216594 CDS YP_001853121.1 183984830 6229152 complement(5916963..5917994) 1 NC_010612.1 involved in active transport of inorganic phosphate across the membrane (import); responsible for the translocation of the substrate across the membrane. this is one of the proteins required for binding-protein- mediated phosphate transport; phosphate-transport integral membrane ABC transporter PstC2 5917994 pstC2_1 6229152 pstC2_1 Mycobacterium marinum M phosphate-transport integral membrane ABC transporter PstC2 YP_001853121.1 5916963 R 216594 CDS YP_001853122.1 183984831 6229153 complement(5918051..5919157) 1 NC_010612.1 involved in phosphate transport; phosphate-binding protein 3 , PhoS3 5919157 phoS3 6229153 phoS3 Mycobacterium marinum M phosphate-binding protein 3 , PhoS3 YP_001853122.1 5918051 R 216594 CDS YP_001853123.1 183984832 6229154 complement(5919294..5920256) 1 NC_010612.1 involved in the fourth step of mycothiol biosynthesis; mycothiol acetyltransferase, MshD 5920256 mshD 6229154 mshD Mycobacterium marinum M mycothiol acetyltransferase, MshD YP_001853123.1 5919294 R 216594 CDS YP_001853124.1 183984833 6229155 complement(5920253..5921047) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 5921047 6229155 MMAR_4865 Mycobacterium marinum M transcriptional regulatory protein YP_001853124.1 5920253 R 216594 CDS YP_001853125.1 183984834 6229156 5921424..5922236 1 NC_010612.1 hypothetical protein 5922236 6229156 MMAR_4866 Mycobacterium marinum M hypothetical protein YP_001853125.1 5921424 D 216594 CDS YP_001853126.1 183984835 6229157 5922536..5923006 1 NC_010612.1 integral membrane protein 5923006 6229157 MMAR_4867 Mycobacterium marinum M integral membrane protein YP_001853126.1 5922536 D 216594 CDS YP_001853127.1 183984836 6229158 5923044..5923886 1 NC_010612.1 may be a sulfotransferase involved in the formation of thiosulfate [catalytic activity: thiosulfate + cyanide = sulfite + thiocyanate]; thiosulfate sulfurtransferase, CysA2 5923886 cysA2 6229158 cysA2 Mycobacterium marinum M thiosulfate sulfurtransferase, CysA2 YP_001853127.1 5923044 D 216594 CDS YP_001853128.1 183984837 6229159 5923888..5924190 1 NC_010612.1 sulfur metabolism protein, SseC2 5924190 sseC2 6229159 sseC2 Mycobacterium marinum M sulfur metabolism protein, SseC2 YP_001853128.1 5923888 D 216594 CDS YP_001853129.1 183984838 6229160 5924247..5924345 1 NC_010612.1 no H37Rv ortholog - very small, doubtful ORF; hypothetical protein 5924345 6229160 MMAR_4870 Mycobacterium marinum M hypothetical protein YP_001853129.1 5924247 D 216594 CDS YP_001853130.1 183984839 6229161 5924342..5925013 1 NC_010612.1 N-terminal truncated in relation to orthologs; hypothetical protein 5925013 6229161 MMAR_4871 Mycobacterium marinum M hypothetical protein YP_001853130.1 5924342 D 216594 CDS YP_001853131.1 183984840 6229162 5925139..5927505 1 NC_010612.1 contains a RyR domain. This domain is called RyR for Ryanodine receptor; hypothetical protein 5927505 6229162 MMAR_4872 Mycobacterium marinum M hypothetical protein YP_001853131.1 5925139 D 216594 CDS YP_001853132.1 183984841 6229163 complement(5927766..5928656) 1 NC_010612.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 5928656 pabC 6229163 pabC Mycobacterium marinum M 4-amino-4-deoxychorismate lyase YP_001853132.1 5927766 R 216594 CDS YP_001853133.1 183984842 6229164 5928791..5929144 1 NC_010612.1 hypothetical protein 5929144 6229164 MMAR_4874 Mycobacterium marinum M hypothetical protein YP_001853133.1 5928791 D 216594 CDS YP_001853134.1 183984843 6229165 5929246..5929554 1 NC_010612.1 hypothetical protein 5929554 6229165 MMAR_4875 Mycobacterium marinum M hypothetical protein YP_001853134.1 5929246 D 216594 CDS YP_001853135.1 183984844 6229166 5929541..5931943 1 NC_010612.1 metal cation-transporting ATPase; possibly catalyzes the transport of undetermined metal cation with hydrolyse of ATP [catalytic activity: ATP + H(2)O + undetermined metal cation(in) = ADP + phosphate + undetermined metal cation (out)]; metal cation transporter p-type ATPase, CtpV 5931943 ctpV 6229166 ctpV Mycobacterium marinum M metal cation transporter p-type ATPase, CtpV YP_001853135.1 5929541 D 216594 CDS YP_001853136.1 183984845 6229167 5931980..5932555 1 NC_010612.1 hypothetical protein 5932555 6229167 MMAR_4877 Mycobacterium marinum M hypothetical protein YP_001853136.1 5931980 D 216594 CDS YP_001853137.1 183984846 6229168 5932577..5933668 1 NC_010612.1 contains predicted aminomethyltransferase domain, related to GcvT - involved in the catabolism of glycine; hypothetical protein 5933668 6229168 MMAR_4878 Mycobacterium marinum M hypothetical protein YP_001853137.1 5932577 D 216594 CDS YP_001853138.1 183984847 6229169 5933827..5934006 1 NC_010612.1 hypothetical protein 5934006 6229169 MMAR_4879 Mycobacterium marinum M hypothetical protein YP_001853138.1 5933827 D 216594 CDS YP_001853139.1 183984848 6229170 complement(5934100..5935203) 1 NC_010612.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 5935203 purM 6229170 purM Mycobacterium marinum M phosphoribosylaminoimidazole synthetase YP_001853139.1 5934100 R 216594 CDS YP_001853140.1 183984849 6229171 complement(5935267..5936793) 1 NC_010612.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 5936793 purF 6229171 purF Mycobacterium marinum M amidophosphoribosyltransferase YP_001853140.1 5935267 R 216594 CDS YP_001853141.1 183984850 6229172 complement(5936932..5937321) 1 NC_010612.1 hypothetical protein 5937321 6229172 MMAR_4882 Mycobacterium marinum M hypothetical protein YP_001853141.1 5936932 R 216594 CDS YP_001853142.1 183984851 6229173 5937341..5938546 1 NC_010612.1 MCE-family protein Mce2A 5938546 mce2A 6229173 mce2A Mycobacterium marinum M MCE-family protein Mce2A YP_001853142.1 5937341 D 216594 CDS YP_001853143.1 183984852 6229174 5938586..5939857 1 NC_010612.1 lipoprotein 5939857 6229174 MMAR_4884 Mycobacterium marinum M lipoprotein YP_001853143.1 5938586 D 216594 CDS YP_001853144.1 183984853 6229175 5940080..5941678 1 NC_010612.1 thought to be involved in exopolysaccharide and/or lipopolysaccharide biosynthetic pathway [catalytic activity: UDP-glucose = UDP-galactose]; UDP-glucose 4-epimerase 5941678 cpsY 6229175 cpsY Mycobacterium marinum M UDP-glucose 4-epimerase YP_001853144.1 5940080 D 216594 CDS YP_001853145.1 183984854 6229176 complement(5941623..5942579) 1 NC_010612.1 contains phosphohydrolase domain; hypothetical protein 5942579 6229176 MMAR_4886 Mycobacterium marinum M hypothetical protein YP_001853145.1 5941623 R 216594 CDS YP_001853146.1 183984855 6229177 complement(5942631..5943245) 1 NC_010612.1 contains CAAX amino terminal protease domain. members of this family are probably proteases; the family contains CAAX prenyl protease. the proteins contain a highly conserved Glu-Glu motif at the amino End of the alignment. the alignment also contains two histidine residues that may be involved in zinc binding; hypothetical protein 5943245 6229177 MMAR_4887 Mycobacterium marinum M hypothetical protein YP_001853146.1 5942631 R 216594 CDS YP_001853147.1 183984856 6229178 complement(5943278..5945575) 1 NC_010612.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 5945575 purL 6229178 purL Mycobacterium marinum M phosphoribosylformylglycinamidine synthase II YP_001853147.1 5943278 R 216594 CDS YP_001853148.1 183984857 6229179 5945673..5946323 1 NC_010612.1 domain similarity with acetyltransferases; hypothetical protein 5946323 6229179 MMAR_4889 Mycobacterium marinum M hypothetical protein YP_001853148.1 5945673 D 216594 CDS YP_001853149.1 183984858 6229180 complement(5946342..5946689) 1 NC_010612.1 hypothetical protein 5946689 6229180 MMAR_4890 Mycobacterium marinum M hypothetical protein YP_001853149.1 5946342 R 216594 CDS YP_001853150.1 183984859 6229181 complement(5946714..5948006) 1 NC_010612.1 catalyzes the removal of amino acids from the N termini of peptides; putative aminopeptidase 2 5948006 pepC 6229181 pepC Mycobacterium marinum M putative aminopeptidase 2 YP_001853150.1 5946714 R 216594 CDS YP_001853151.1 183984860 6229182 5948059..5949066 1 NC_010612.1 contains Dyp-type peroxidase domain. this family of dye-decolourising peroxidases lack a typical heme-binding region; hypothetical protein 5949066 6229182 MMAR_4892 Mycobacterium marinum M hypothetical protein YP_001853151.1 5948059 D 216594 CDS YP_001853152.1 183984861 6229183 5949063..5949869 1 NC_010612.1 function unknown, high domain homology to Linocin_M18, Linocin_M18 bacteriocin protein. the Linocin_M18 region is found mostly in eubacteria, though homologous sequences have been identified in archaea; 29 kDa antigen Cfp29 5949869 cfp29 6229183 cfp29 Mycobacterium marinum M 29 kDa antigen Cfp29 YP_001853152.1 5949063 D 216594 CDS YP_001853153.1 183984862 6229184 5950427..5951911 1 NC_010612.1 contains pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component domain; dihydrolipoamide dehydrogenase, LpdB 5951911 lpdB 6229184 lpdB Mycobacterium marinum M dihydrolipoamide dehydrogenase, LpdB YP_001853153.1 5950427 D 216594 CDS YP_001853154.1 183984863 6229185 5951937..5952401 1 NC_010612.1 contains mannose-6-phosphate isomerase [carbohydrate transport and metabolism]; hypothetical protein 5952401 6229185 MMAR_4895 Mycobacterium marinum M hypothetical protein YP_001853154.1 5951937 D 216594 CDS YP_001853155.1 183984864 6229186 5952502..5952966 1 NC_010612.1 hypothetical protein 5952966 6229186 MMAR_4896 Mycobacterium marinum M hypothetical protein YP_001853155.1 5952502 D 216594 CDS YP_001853156.1 183984865 6229187 complement(5952978..5953652) 1 NC_010612.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 5953652 purQ 6229187 purQ Mycobacterium marinum M phosphoribosylformylglycinamidine synthase I YP_001853156.1 5952978 R 216594 CDS YP_001853157.1 183984866 6229188 complement(5953649..5953894) 1 NC_010612.1 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS 5953894 6229188 MMAR_4898 Mycobacterium marinum M phosphoribosylformylglycinamidine synthase subunit PurS YP_001853157.1 5953649 R 216594 CDS YP_001853158.1 183984867 6229189 5954217..5955284 1 NC_010612.1 PPE family protein 5955284 6229189 MMAR_4899 Mycobacterium marinum M PPE family protein YP_001853158.1 5954217 D 216594 CDS YP_001853159.1 183984868 6229190 complement(5955311..5956030) 1 NC_010612.1 hypothetical protein 5956030 6229190 MMAR_4900 Mycobacterium marinum M hypothetical protein YP_001853159.1 5955311 R 216594 CDS YP_001853160.1 183984869 6229191 5956016..5956654 1 NC_010612.1 Zn-dependent hydrolase 5956654 6229191 MMAR_4901 Mycobacterium marinum M Zn-dependent hydrolase YP_001853160.1 5956016 D 216594 CDS YP_001853161.1 183984870 6229192 complement(5956734..5957648) 1 NC_010612.1 function unknown; belongs to the LysR family of transcriptional regulators; putative regulatory protein 5957648 6229192 MMAR_4902 Mycobacterium marinum M putative regulatory protein YP_001853161.1 5956734 R 216594 CDS YP_001853162.1 183984871 6229193 5957772..5958779 1 NC_010612.1 hypothetical protein 5958779 6229193 MMAR_4903 Mycobacterium marinum M hypothetical protein YP_001853162.1 5957772 D 216594 CDS YP_001853163.1 183984872 6229194 complement(5958737..5959441) 1 NC_010612.1 hypothetical protein 5959441 6229194 MMAR_4904 Mycobacterium marinum M hypothetical protein YP_001853163.1 5958737 R 216594 CDS YP_001853164.1 183984873 6229195 5959610..5961229 1 NC_010612.1 translocase that confers resistance to substances of high hydrophobicity. involved in transport of multidrug across the membrane (export): multidrug resistance by an export mechanism. responsible for the translocation of the substrate across the membrane; integral membrane drug efflux protein 5961229 6229195 MMAR_4905 Mycobacterium marinum M integral membrane drug efflux protein YP_001853164.1 5959610 D 216594 CDS YP_001853165.1 183984874 6229196 complement(5961219..5961782) 1 NC_010612.1 TetR-family; transcriptional regulator 5961782 6229196 MMAR_4906 Mycobacterium marinum M transcriptional regulator YP_001853165.1 5961219 R 216594 CDS YP_001853166.1 183984875 6229197 5961877..5962326 1 NC_010612.1 hypothetical protein 5962326 6229197 MMAR_4907 Mycobacterium marinum M hypothetical protein YP_001853166.1 5961877 D 216594 CDS YP_001853167.1 183984876 6229198 complement(5962285..5964402) 1 NC_010612.1 cleaves peptide bonds on the C-terminal side of LysYL and argininyl residues [catalytic activity: hydrolysis of arg-|-xaa and lys-|-xaa bonds in oligopeptides, even when P1' residue is proline]; protease II (oligopeptidase B), PtrB 5964402 ptrB 6229198 ptrB Mycobacterium marinum M protease II (oligopeptidase B), PtrB YP_001853167.1 5962285 R 216594 CDS YP_001853168.1 183984877 6229199 complement(5964399..5965292) 1 NC_010612.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 5965292 purC 6229199 purC Mycobacterium marinum M phosphoribosylaminoimidazole-succinocarboxamide synthase YP_001853168.1 5964399 R 216594 CDS YP_001853169.1 183984878 6229200 5965357..5965977 1 NC_010612.1 transmembrane protein 5965977 6229200 MMAR_4910 Mycobacterium marinum M transmembrane protein YP_001853169.1 5965357 D 216594 CDS YP_001853170.1 183984879 6229201 complement(5965968..5967029) 1 NC_010612.1 Zn-dependent alcohol dehydrogenase, AdhX 5967029 adhX 6229201 adhX Mycobacterium marinum M Zn-dependent alcohol dehydrogenase, AdhX YP_001853170.1 5965968 R 216594 CDS YP_001853171.1 183984880 6229202 complement(5967081..5968604) 1 NC_010612.1 interconversion aldehyde and acid [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; aldehyde dehydrogenase 5968604 6229202 MMAR_4912 Mycobacterium marinum M aldehyde dehydrogenase YP_001853171.1 5967081 R 216594 CDS YP_001853172.1 183984881 6229203 complement(5968736..5970019) 1 NC_010612.1 possibly involed in transcription regulation; DNA- binding; putative regulatory protein 5970019 6229203 MMAR_4913 Mycobacterium marinum M putative regulatory protein YP_001853172.1 5968736 R 216594 CDS YP_001853173.1 183984882 6229204 complement(5970229..5971437) 1 NC_010612.1 PPE family protein 5971437 6229204 MMAR_4914 Mycobacterium marinum M PPE family protein YP_001853173.1 5970229 R 216594 CDS YP_001853174.1 183984883 6229205 complement(5971724..5972980) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 126A3 Cyp126A3 5972980 cyp126A3 6229205 cyp126A3 Mycobacterium marinum M cytochrome P450 126A3 Cyp126A3 YP_001853174.1 5971724 R 216594 CDS YP_001853175.1 183984884 6229206 complement(5972977..5974404) 1 NC_010612.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 5974404 purB 6229206 purB Mycobacterium marinum M adenylosuccinate lyase YP_001853175.1 5972977 R 216594 CDS YP_001853176.1 183984885 6229207 5974523..5975284 1 NC_010612.1 hypothetical protein 5975284 6229207 MMAR_4917 Mycobacterium marinum M hypothetical protein YP_001853176.1 5974523 D 216594 CDS YP_001853177.1 183984886 6229208 complement(5975281..5975904) 1 NC_010612.1 contains transcriptional regulatory domain; hypothetical protein 5975904 6229208 MMAR_4918 Mycobacterium marinum M hypothetical protein YP_001853177.1 5975281 R 216594 CDS YP_001853178.1 183984887 6229209 5975960..5976871 1 NC_010612.1 function unknown, contains esterase domain; hypothetical protein 5976871 6229209 MMAR_4919 Mycobacterium marinum M hypothetical protein YP_001853178.1 5975960 D 216594 CDS YP_001853179.1 183984888 6229210 5976939..5978540 1 NC_010612.1 besides the cephalosporin acylase I activity which converts GL-7ACA into 7-Aca; this enzyme displays some gamma glutamyltranspeptidase activity: Ggt plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione. [catalytic activity 1: 7-beta-(4-carboxybutanamido)-cephalosporanic acid + H2O = 7-aminocephalosporanic acid + glutaric acid] [catalytic activity 2: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid]; bifunctional acylase, GgtA 5978540 ggtA 6229210 ggtA Mycobacterium marinum M bifunctional acylase, GgtA YP_001853179.1 5976939 D 216594 CDS YP_001853180.1 183984889 6229211 5978988..5981114 1 NC_010612.1 involved in biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (MoaD); hypothetical protein 5981114 moeY 6229211 moeY Mycobacterium marinum M hypothetical protein YP_001853180.1 5978988 D 216594 CDS YP_001853181.1 183984890 6229212 complement(5981143..5982057) 1 NC_010612.1 domain: UspA, universal stress protein UspA and related nucleotide-binding proteins [signal transduction mechanisms]; hypothetical protein 5982057 6229212 MMAR_4922 Mycobacterium marinum M hypothetical protein YP_001853181.1 5981143 R 216594 CDS YP_001853182.1 183984891 6229213 5982387..5983925 1 NC_010612.1 involved in signal transduction (via phosphorylation). [catalytic activity: ATP + a protein = ADP + a phosphoprotein]; serine/threonine-protein kinase PknF_2 5983925 pknF_2 6229213 pknF_2 Mycobacterium marinum M serine/threonine-protein kinase PknF_2 YP_001853182.1 5982387 D 216594 CDS YP_001853183.1 183984892 6229214 complement(5983965..5985233) 1 NC_010612.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 5985233 purD 6229214 purD Mycobacterium marinum M phosphoribosylamine--glycine ligase YP_001853183.1 5983965 R 216594 CDS YP_001853184.1 183984893 6229215 complement(5985272..5985709) 1 NC_010612.1 involved in aromatic hydrocarbons catabolism. thought to be involved in the catabolism of protocatechuate to succinate-and acetyl-CoA in the beta- ketoadipate pathway (at the third step) [catalytic activity: 2-carboxy-5-OXO-2,5-dihydrofuran-2-acetate = 5- OXO-4,5-dihydrofuran-2-acetate + CO(2)]; 4-carboxymuconolactone decarboxylase 5985709 6229215 MMAR_4925 Mycobacterium marinum M 4-carboxymuconolactone decarboxylase YP_001853184.1 5985272 R 216594 CDS YP_001853185.1 183984894 6229216 complement(5985709..5986575) 1 NC_010612.1 dehydrogenase/reductase 5986575 6229216 MMAR_4926 Mycobacterium marinum M dehydrogenase/reductase YP_001853185.1 5985709 R 216594 CDS YP_001853186.1 183984895 6229217 complement(5986622..5987374) 1 NC_010612.1 short chain dehydrogenase 5987374 6229217 MMAR_4927 Mycobacterium marinum M short chain dehydrogenase YP_001853186.1 5986622 R 216594 CDS YP_001853187.1 183984896 6229218 complement(5987385..5988854) 1 NC_010612.1 oxidizes a variety of aldehydes [catalytic activity: an aldehyde + NAD+ + H2O = an acid + NADH]; NAD-dependent aldehyde dehydrogenase AldA 5988854 aldA 6229218 aldA Mycobacterium marinum M NAD-dependent aldehyde dehydrogenase AldA YP_001853187.1 5987385 R 216594 CDS YP_001853188.1 183984897 6229219 5989060..5989728 1 NC_010612.1 hypothetical protein 5989728 6229219 MMAR_4929 Mycobacterium marinum M hypothetical protein YP_001853188.1 5989060 D 216594 CDS YP_001853189.1 183984898 6229220 5989725..5990945 1 NC_010612.1 cytochrome P450s are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 123A3 Cyp123A3 5990945 cyp123A3 6229220 cyp123A3 Mycobacterium marinum M cytochrome P450 123A3 Cyp123A3 YP_001853189.1 5989725 D 216594 CDS YP_001853190.1 183984899 6229221 5990945..5991769 1 NC_010612.1 function unknown, domain homology to short-chain dehydrogenase/reductase family; short chain dehydrogenase 5991769 6229221 MMAR_4931 Mycobacterium marinum M short chain dehydrogenase YP_001853190.1 5990945 D 216594 CDS YP_001853191.1 183984900 6229222 5991766..5993136 1 NC_010612.1 involved in sterol biosynthesis. its biological substrate is not known. catalyzes C14-demethylation of lanosterol, 24,25-DIHYDROLANOSTEROL and obtusifoliol which is critical for ergosterol biosynthesis. it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3- beta-ol; cytochrome P450 51B1 Cyp51B1 5993136 cyp51B1 6229222 cyp51B1 Mycobacterium marinum M cytochrome P450 51B1 Cyp51B1 YP_001853191.1 5991766 D 216594 CDS YP_001853192.1 183984901 6229223 5993136..5993342 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. probably involved in electron transport for cytochrome P- 450 system; ferredoxin 5993342 6229223 MMAR_4933 Mycobacterium marinum M ferredoxin YP_001853192.1 5993136 D 216594 CDS YP_001853193.1 183984902 6229224 5993348..5993893 1 NC_010612.1 hypothetical protein 5993893 6229224 MMAR_4934 Mycobacterium marinum M hypothetical protein YP_001853193.1 5993348 D 216594 CDS YP_001853194.1 183984903 6229225 5994056..5995183 1 NC_010612.1 thought to catalyze the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD. probably acts on primary or secondary alcohols or hemiacetals [catalytic activity: an alcohol + NAD+ = an aldehyde or ketone + NADH]; zinc-containing alcohol dehydrogenase NAD- dependent AdhB 5995183 adhB 6229225 adhB Mycobacterium marinum M zinc-containing alcohol dehydrogenase NAD- dependent AdhB YP_001853194.1 5994056 D 216594 CDS YP_001853195.1 183984904 6229226 5995213..5995497 1 NC_010612.1 function unknown, domain homology suggests possible NADH:flavin oxidoreductase; hypothetical protein 5995497 6229226 MMAR_4936 Mycobacterium marinum M hypothetical protein YP_001853195.1 5995213 D 216594 CDS YP_001853196.1 183984905 6229227 5995500..5995919 1 NC_010612.1 contains nuclear transport factor 2 (NTF2) domain; hypothetical protein 5995919 6229227 MMAR_4937 Mycobacterium marinum M hypothetical protein YP_001853196.1 5995500 D 216594 CDS YP_001853197.1 183984906 6229228 complement(5995921..5997363) 1 NC_010612.1 hypothetical protein 5997363 6229228 MMAR_4938 Mycobacterium marinum M hypothetical protein YP_001853197.1 5995921 R 216594 CDS YP_001853198.1 183984907 6229229 5997792..5999183 1 NC_010612.1 PE-PGRS family protein 5999183 6229229 MMAR_4939 Mycobacterium marinum M PE-PGRS family protein YP_001853198.1 5997792 D 216594 CDS YP_001853199.1 183984908 6229230 5999188..5999592 1 NC_010612.1 hit family protein: diadenosine tetraphosphate (Ap4A) hydrolase and other hit family hydrolases [nucleotide transport and metabolism / carbohydrate transport and metabolism / general function prediction only]; hypothetical protein 5999592 6229230 MMAR_4940 Mycobacterium marinum M hypothetical protein YP_001853199.1 5999188 D 216594 CDS YP_001853200.1 183984909 6229231 complement(5999599..6001044) 1 NC_010612.1 sensor part of a two-component regulatory system. this protein is thought to be a sensor kinase for the phosphate regulon. transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited; two-component system response phosphate sensor kinase, PhoR 6001044 phoR 6229231 phoR Mycobacterium marinum M two-component system response phosphate sensor kinase, PhoR YP_001853200.1 5999599 R 216594 CDS YP_001853201.1 183984910 6229232 complement(6001085..6001807) 1 NC_010612.1 involved in transcriptional mechanism. part of the two-component regulatory system PhoP/PhoQ. this protein is thought to be a positive regulator for the phosphate regulon, required for intracellular growth. transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited; two-component system response phosphate regulon transcriptional regulator, PhoP 6001807 phoP 6229232 phoP Mycobacterium marinum M two-component system response phosphate regulon transcriptional regulator, PhoP YP_001853201.1 6001085 R 216594 CDS YP_001853202.1 183984911 6229233 6001969..6002697 1 NC_010612.1 hypothetical protein 6002697 6229233 MMAR_4943 Mycobacterium marinum M hypothetical protein YP_001853202.1 6001969 D 216594 CDS YP_001853203.1 183984912 6229235 6003001..6004167 1 NC_010612.1 domain: UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [coenzyme metabolism / energy production and conversion]; oxidoreductase 6004167 6229235 MMAR_4944 Mycobacterium marinum M oxidoreductase YP_001853203.1 6003001 D 216594 CDS YP_001853204.1 183984913 6229236 complement(6004151..6006853) 1 NC_010612.1 carbon monoxide dehydrogenase 6006853 6229236 MMAR_4945 Mycobacterium marinum M carbon monoxide dehydrogenase YP_001853204.1 6004151 R 216594 CDS YP_001853205.1 183984914 6229237 complement(6006850..6007674) 1 NC_010612.1 domain: xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit a [nucleotide transport and metabolism]; hypothetical protein 6007674 6229237 MMAR_4946 Mycobacterium marinum M hypothetical protein YP_001853205.1 6006850 R 216594 CDS YP_001853206.1 183984915 6229238 complement(6007674..6007994) 1 NC_010612.1 domain homology: transthyretin, transthyretin precursor (formerly prealbumin). transthyretin is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. mutations in the human transthyretin are associated with several genetic disorders; hypothetical protein 6007994 6229238 MMAR_4947 Mycobacterium marinum M hypothetical protein YP_001853206.1 6007674 R 216594 CDS YP_001853207.1 183984916 6229239 complement(6008032..6008535) 1 NC_010612.1 putative OHCU decarboxylase 6008535 6229239 MMAR_4948 Mycobacterium marinum M putative OHCU decarboxylase YP_001853207.1 6008032 R 216594 CDS YP_001853208.1 183984917 6229240 complement(6008536..6010437) 1 NC_010612.1 permease family. this family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. however many members of this family are functionally uncharacterised and may transport other substrates. members of this family have ten predicted transmembrane helices; xanthine/uracil permease 6010437 6229240 MMAR_4949 Mycobacterium marinum M xanthine/uracil permease YP_001853208.1 6008536 R 216594 CDS YP_001853209.1 183984918 6229241 complement(6010518..6012929) 1 NC_010612.1 thought to play an important role in the mineralization of sulfates [catalytic activity: a phenol sulfate + H2O = a phenol + sulfate]; arylsulfatase AtsD 6012929 atsD 6229241 atsD Mycobacterium marinum M arylsulfatase AtsD YP_001853209.1 6010518 R 216594 CDS YP_001853210.1 183984919 6229242 6013166..6014380 1 NC_010612.1 domain: regulator of polyketide synthase expression; hypothetical protein 6014380 6229242 MMAR_4951 Mycobacterium marinum M hypothetical protein YP_001853210.1 6013166 D 216594 CDS YP_001853211.1 183984920 6229243 complement(6014391..6015197) 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 6015197 echA8_3 6229243 echA8_3 Mycobacterium marinum M enoyl-CoA hydratase YP_001853211.1 6014391 R 216594 CDS YP_001853212.1 183984921 6229244 complement(6015223..6016956) 1 NC_010612.1 PE-PGRS family protein 6016956 6229244 MMAR_4953 Mycobacterium marinum M PE-PGRS family protein YP_001853212.1 6015223 R 216594 CDS YP_001853213.1 183984922 6229245 6017199..6018692 1 NC_010612.1 hydrolyzes a monocarboxylic acid amide and generates a monocarboxylate [catalytic activity: a monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3)]; amidase 6018692 amiC_2 6229245 amiC_2 Mycobacterium marinum M amidase YP_001853213.1 6017199 D 216594 CDS YP_001853214.1 183984923 6229246 complement(6018713..6020203) 1 NC_010612.1 hypothetical protein 6020203 6229246 MMAR_4955 Mycobacterium marinum M hypothetical protein YP_001853214.1 6018713 R 216594 CDS YP_001853215.1 183984924 6229247 6020414..6022051 1 NC_010612.1 function unknown; facilitates transport of small solutes in or out of the cell; multidrug resistance integral membrane efflux protein 6022051 6229247 MMAR_4956 Mycobacterium marinum M multidrug resistance integral membrane efflux protein YP_001853215.1 6020414 D 216594 CDS YP_001853216.1 183984925 6229248 complement(6022093..6022575) 1 NC_010612.1 hypothetical protein 6022575 6229248 MMAR_4957 Mycobacterium marinum M hypothetical protein YP_001853216.1 6022093 R 216594 CDS YP_001853217.1 183984926 6229249 6022708..6023094 1 NC_010612.1 hypothetical protein 6023094 6229249 MMAR_4958 Mycobacterium marinum M hypothetical protein YP_001853217.1 6022708 D 216594 CDS YP_001853218.1 183984927 6229250 6023215..6023478 1 NC_010612.1 hypothetical protein 6023478 6229250 MMAR_4959 Mycobacterium marinum M hypothetical protein YP_001853218.1 6023215 D 216594 CDS YP_001853219.1 183984928 6229251 complement(6023547..6024422) 1 NC_010612.1 supposed involved in detoxification reactions; peroxidase BpoA 6024422 bpoA 6229251 bpoA Mycobacterium marinum M peroxidase BpoA YP_001853219.1 6023547 R 216594 CDS YP_001853220.1 183984929 6229252 complement(6024527..6025216) 1 NC_010612.1 hypothetical protein 6025216 6229252 MMAR_4961 Mycobacterium marinum M hypothetical protein YP_001853220.1 6024527 R 216594 CDS YP_001853221.1 183984930 6229253 complement(6025299..6026450) 1 NC_010612.1 possibly involved in the uptake of malate and other dicarboxylates by a proton symport mechanism. in E. coli, this protein has been implicated in resistance to tellurite; C4-dicarboxylate transporter/malic acid transport protein 6026450 6229253 MMAR_4962 Mycobacterium marinum M C4-dicarboxylate transporter/malic acid transport protein YP_001853221.1 6025299 R 216594 CDS YP_001853222.1 183984931 6229254 6026654..6026896 1 NC_010612.1 hypothetical protein 6026896 6229254 MMAR_4963 Mycobacterium marinum M hypothetical protein YP_001853222.1 6026654 D 216594 CDS YP_001853223.1 183984932 6229255 complement(6026952..6027695) 1 NC_010612.1 hypothetical protein 6027695 6229255 MMAR_4964 Mycobacterium marinum M hypothetical protein YP_001853223.1 6026952 R 216594 CDS YP_001853224.1 183984933 6229256 complement(6027764..6028468) 1 NC_010612.1 hypothetical protein 6028468 6229256 MMAR_4965 Mycobacterium marinum M hypothetical protein YP_001853224.1 6027764 R 216594 CDS YP_001853225.1 183984934 6229257 6028733..6030268 1 NC_010612.1 function unknown but contains a cell envelope- related transcriptional attenuator domain. CpsA is a domain of unknown function that is found in the predicted extracellular domain of a number of putative membrane- bound proteins. may play a role in regulation of transcription; membrane protein CpsA 6030268 cpsA 6229257 cpsA Mycobacterium marinum M membrane protein CpsA YP_001853225.1 6028733 D 216594 CDS YP_001853226.1 183984935 6229258 complement(6030275..6031066) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; short-chain type dehydrogenase/reductase 6031066 6229258 MMAR_4967 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001853226.1 6030275 R 216594 CDS YP_001853227.1 183984936 6229259 complement(6031070..6031903) 1 NC_010612.1 function unknown, supposed to be involved in cellular metabolism; short chain dehydrogenase 6031903 6229259 MMAR_4968 Mycobacterium marinum M short chain dehydrogenase YP_001853227.1 6031070 R 216594 CDS YP_001853228.1 183984937 6229260 complement(6031995..6032237) 1 NC_010612.1 probable role in the biosynthesis of the product from U/S PKS gene, carrying its acyl intermediates; acyl carrier protein 6032237 6229260 MMAR_4969 Mycobacterium marinum M acyl carrier protein YP_001853228.1 6031995 R 216594 CDS YP_001853229.1 183984938 6229261 complement(6032234..6033883) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 6033883 6229261 MMAR_4970 Mycobacterium marinum M long-chain-fatty-acid--CoA ligase YP_001853229.1 6032234 R 216594 CDS YP_001853230.1 183984939 6229262 complement(6034024..6035268) 1 NC_010612.1 could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]; 8-amino-7-oxononanoate synthase 6035268 bioF2 6229262 bioF2 Mycobacterium marinum M 8-amino-7-oxononanoate synthase YP_001853230.1 6034024 R 216594 CDS YP_001853231.1 183984940 6229263 complement(6035459..6036394) 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 6036394 echA13_1 6229263 echA13_1 Mycobacterium marinum M enoyl-CoA hydratase YP_001853231.1 6035459 R 216594 CDS YP_001853232.1 183984941 6229264 complement(6036461..6037294) 1 NC_010612.1 function unknown but domain identity suggests permease component of an uncharacterized ABC-type transport system; hypothetical protein 6037294 6229264 MMAR_4973 Mycobacterium marinum M hypothetical protein YP_001853232.1 6036461 R 216594 CDS YP_001853233.1 183984942 6229265 complement(6037294..6037974) 1 NC_010612.1 involved in active transport of inorganic phosphate across the membrane (import); responsible for energy coupling to the transport system. this is one of the proteins required for binding-protein-mediated phosphate transport. have ATP-binding ability and ATPase activity; phosphate-transport ATP-binding protein ABC transporter PstB 6037974 pstB 6229265 pstB Mycobacterium marinum M phosphate-transport ATP-binding protein ABC transporter PstB YP_001853233.1 6037294 R 216594 CDS YP_001853234.1 183984943 6229266 6038674..6041613 1 NC_010612.1 function unknown. belongs to the predicted drug exporters of the rnd superfamily; MmpL family transport protein 6041613 6229266 MMAR_4975 Mycobacterium marinum M MmpL family transport protein YP_001853234.1 6038674 D 216594 CDS YP_001853235.1 183984944 6229267 6041704..6042006 1 NC_010612.1 members of the PadR-like family are transcriptional regulators that appear to be related to the pfam01047 family. this family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism; hypothetical protein 6042006 6229267 MMAR_4976 Mycobacterium marinum M hypothetical protein YP_001853235.1 6041704 D 216594 CDS YP_001853236.1 183984945 6229268 6042074..6042238 1 NC_010612.1 hypothetical protein 6042238 6229268 MMAR_4977 Mycobacterium marinum M hypothetical protein YP_001853236.1 6042074 D 216594 CDS YP_001853237.1 183984946 6229269 6042239..6043741 1 NC_010612.1 involved in osmoregulatory trehalose biosynthesis. mycobacteria can produce trehalose from glucose 6- phosphate and UDP-glucose (the OtsA-OtsB pathway) from glycogen-like alpha(1-->4)-linked glucose polymers (the TreY-TreZ pathway) and from maltose (the TreS pathway) [catalytic activity: trehalose 6-phosphate + H(2)O = trehalose + orthophosphate]; alpha, alpha-trehalose-phosphate synthase OtsA 6043741 otsA 6229269 otsA Mycobacterium marinum M alpha, alpha-trehalose-phosphate synthase OtsA YP_001853237.1 6042239 D 216594 CDS YP_001853238.1 183984947 6229270 6043829..6044410 1 NC_010612.1 hypothetical protein 6044410 6229270 MMAR_4979 Mycobacterium marinum M hypothetical protein YP_001853238.1 6043829 D 216594 CDS YP_001853239.1 183984948 6229271 complement(6044455..6044955) 1 NC_010612.1 MCE-associated protein 6044955 6229271 MMAR_4980 Mycobacterium marinum M MCE-associated protein YP_001853239.1 6044455 R 216594 CDS YP_001853240.1 183984949 6229272 complement(6044955..6045686) 1 NC_010612.1 hypothetical protein 6045686 6229272 MMAR_4981 Mycobacterium marinum M hypothetical protein YP_001853240.1 6044955 R 216594 CDS YP_001853241.1 183984950 6229273 complement(6045719..6047401) 1 NC_010612.1 function unknown, but thought involved in host cell invasion; MCE-family protein Mce4F 6047401 mce4F 6229273 mce4F Mycobacterium marinum M MCE-family protein Mce4F YP_001853241.1 6045719 R 216594 CDS YP_001853242.1 183984951 6229274 complement(6047413..6048564) 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE family lipoprotein LprN 6048564 lprN 6229274 lprN Mycobacterium marinum M MCE family lipoprotein LprN YP_001853242.1 6047413 R 216594 CDS YP_001853243.1 183984952 6229275 complement(6048561..6049994) 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce4D 6049994 mce4D 6229275 mce4D Mycobacterium marinum M MCE-family protein Mce4D YP_001853243.1 6048561 R 216594 CDS YP_001853244.1 183984953 6229276 complement(6049991..6051052) 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce4C 6051052 mce4C 6229276 mce4C Mycobacterium marinum M MCE-family protein Mce4C YP_001853244.1 6049991 R 216594 CDS YP_001853245.1 183984954 6229277 complement(6051042..6052094) 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce4B 6052094 mce4B 6229277 mce4B Mycobacterium marinum M MCE-family protein Mce4B YP_001853245.1 6051042 R 216594 CDS YP_001853246.1 183984955 6229278 complement(6052094..6053296) 1 NC_010612.1 function unknown, but thought to be involved in host cell invasion; MCE-family protein Mce4A 6053296 mce4A 6229278 mce4A Mycobacterium marinum M MCE-family protein Mce4A YP_001853246.1 6052094 R 216594 CDS YP_001853247.1 183984956 6229279 complement(6053312..6054154) 1 NC_010612.1 membrane protein YrbE4B 6054154 yrbE4B 6229279 yrbE4B Mycobacterium marinum M membrane protein YrbE4B YP_001853247.1 6053312 R 216594 CDS YP_001853248.1 183984957 6229280 complement(6054189..6054902) 1 NC_010612.1 membrane protein YrbE4A 6054902 yrbE4A 6229280 yrbE4A Mycobacterium marinum M membrane protein YrbE4A YP_001853248.1 6054189 R 216594 CDS YP_001853249.1 183984958 6229281 complement(6055190..6056101) 1 NC_010612.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 6056101 fabG 6229281 fabG Mycobacterium marinum M 3-ketoacyl-ACP reductase YP_001853249.1 6055190 R 216594 CDS YP_001853250.1 183984959 6229282 complement(6056172..6056420) 1 NC_010612.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; ferredoxin FdxD 6056420 fdxD 6229282 fdxD Mycobacterium marinum M ferredoxin FdxD YP_001853250.1 6056172 R 216594 CDS YP_001853251.1 183984960 6229283 6056588..6057766 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE26 6057766 fadE26 6229283 fadE26 Mycobacterium marinum M acyl-CoA dehydrogenase FadE26 YP_001853251.1 6056588 D 216594 CDS YP_001853252.1 183984961 6229284 6057797..6058894 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE27 6058894 fadE27 6229284 fadE27 Mycobacterium marinum M acyl-CoA dehydrogenase FadE27 YP_001853252.1 6057797 D 216594 CDS YP_001853253.1 183984962 6229285 6058957..6060468 1 NC_010612.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 6060468 fadD17 6229285 fadD17 Mycobacterium marinum M acyl-CoA synthetase YP_001853253.1 6058957 D 216594 CDS YP_001853254.1 183984963 6229286 6060576..6064802 1 NC_010612.1 PE-PGRS family protein 6064802 6229286 MMAR_4995 Mycobacterium marinum M PE-PGRS family protein YP_001853254.1 6060576 D 216594 CDS YP_001853255.1 183984964 6229287 6064805..6065527 1 NC_010612.1 function unknown but contains beta- lactamase/transpeptidase-like superfamily domain; hypothetical protein 6065527 6229287 MMAR_4996 Mycobacterium marinum M hypothetical protein YP_001853255.1 6064805 D 216594 CDS YP_001853256.1 183984965 6229288 complement(6065524..6067071) 1 NC_010612.1 thiamine-pyrophosphate requiring enzyme; hypothetical protein 6067071 ilvX 6229288 ilvX Mycobacterium marinum M hypothetical protein YP_001853256.1 6065524 R 216594 CDS YP_001853257.1 183984966 6229289 complement(6067084..6067914) 1 NC_010612.1 function unknown. these proteins are related to the metal-dependent hydrolase superfamily; hypothetical protein 6067914 6229289 MMAR_4998 Mycobacterium marinum M hypothetical protein YP_001853257.1 6067084 R 216594 CDS YP_001853258.1 183984967 6229290 6068164..6072894 1 NC_010612.1 PE-PGRS family protein 6072894 6229290 MMAR_4999 Mycobacterium marinum M PE-PGRS family protein YP_001853258.1 6068164 D 216594 CDS YP_001853259.1 183984968 6229291 complement(6073476..6074243) 1 NC_010612.1 fructosamine kinase-like protein 6074243 6229291 MMAR_5000 Mycobacterium marinum M fructosamine kinase-like protein YP_001853259.1 6073476 R 216594 CDS YP_001853260.1 183984969 6229292 complement(6074257..6075909) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase 6075909 fadD19_1 6229292 fadD19_1 Mycobacterium marinum M acyl-CoA synthetase YP_001853260.1 6074257 R 216594 CDS YP_001853261.1 183984970 6229293 6075974..6076798 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 6076798 echA19 6229293 echA19 Mycobacterium marinum M enoyl-CoA hydratase YP_001853261.1 6075974 D 216594 CDS YP_001853262.1 183984971 6229294 complement(6076816..6078021) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 142A3 Cyp142A3 6078021 cyp142A3 6229294 cyp142A3 Mycobacterium marinum M cytochrome P450 142A3 Cyp142A3 YP_001853262.1 6076816 R 216594 CDS YP_001853263.1 183984972 6229295 6078051..6078761 1 NC_010612.1 hypothetical protein 6078761 6229295 MMAR_5004 Mycobacterium marinum M hypothetical protein YP_001853263.1 6078051 D 216594 CDS YP_001853264.1 183984973 6229296 complement(6078822..6079859) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; coenzyme F420-dependent oxidoreductase 6079859 6229296 MMAR_5005 Mycobacterium marinum M coenzyme F420-dependent oxidoreductase YP_001853264.1 6078822 R 216594 CDS YP_001853265.1 183984974 6229297 6079930..6080919 1 NC_010612.1 function unknown, contains a C-term predicted nucleic-acid-binding domain; hypothetical protein 6080919 6229297 MMAR_5006 Mycobacterium marinum M hypothetical protein YP_001853265.1 6079930 D 216594 CDS YP_001853266.1 183984975 6229298 6080935..6081996 1 NC_010612.1 function unknown, probably involved in lipid metabolism; lipid-transfer protein 6081996 ltp4 6229298 ltp4 Mycobacterium marinum M lipid-transfer protein YP_001853266.1 6080935 D 216594 CDS YP_001853267.1 183984976 6229299 6081996..6083174 1 NC_010612.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 6083174 ltp3 6229299 ltp3 Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001853267.1 6081996 D 216594 CDS YP_001853268.1 183984977 6229300 6083171..6084061 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 6084061 6229300 MMAR_5009 Mycobacterium marinum M oxidoreductase YP_001853268.1 6083171 D 216594 CDS YP_001853269.1 183984978 6229301 6084058..6084468 1 NC_010612.1 function unknown, this class of proteins is involved in enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon; ketosteroid isomerase- like protein 6084468 6229301 MMAR_5010 Mycobacterium marinum M ketosteroid isomerase- like protein YP_001853269.1 6084058 D 216594 CDS YP_001853270.1 183984979 6229302 6084569..6085513 1 NC_010612.1 hypothetical protein 6085513 6229302 MMAR_5011 Mycobacterium marinum M hypothetical protein YP_001853270.1 6084569 D 216594 CDS YP_001853271.1 183984980 6229303 6085720..6086658 1 NC_010612.1 hypothetical protein 6086658 6229303 MMAR_5012 Mycobacterium marinum M hypothetical protein YP_001853271.1 6085720 D 216594 CDS YP_001853272.1 183984981 6229304 6086762..6088396 1 NC_010612.1 function unknown. seems to influence both cell surface interactions among mycobacteria and the interactions of bacteria with macrophages; PE-PGRS family protein 6088396 6229304 MMAR_5013 Mycobacterium marinum M PE-PGRS family protein YP_001853272.1 6086762 D 216594 CDS YP_001853273.1 183984982 6229305 complement(6088403..6088927) 1 NC_010612.1 function unknown, contains carbonic anhydrases/acetyltransferase superfamily domain; hypothetical protein 6088927 6229305 MMAR_5014 Mycobacterium marinum M hypothetical protein YP_001853273.1 6088403 R 216594 CDS YP_001853274.1 183984983 6229306 6089041..6090225 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 6090225 6229306 MMAR_5015 Mycobacterium marinum M oxidoreductase YP_001853274.1 6089041 D 216594 CDS YP_001853275.1 183984984 6229307 6090231..6090680 1 NC_010612.1 hypothetical protein 6090680 6229307 MMAR_5016 Mycobacterium marinum M hypothetical protein YP_001853275.1 6090231 D 216594 CDS YP_001853276.1 183984985 6229308 complement(6090684..6091829) 1 NC_010612.1 function unknown, contains P-loop containing nucleoside triphosphate hydrolase superfamily domain; hypothetical protein 6091829 6229308 MMAR_5017 Mycobacterium marinum M hypothetical protein YP_001853276.1 6090684 R 216594 CDS YP_001853277.1 183984986 6229309 complement(6091829..6092611) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; short chain dehydrogenase 6092611 6229309 MMAR_5018 Mycobacterium marinum M short chain dehydrogenase YP_001853277.1 6091829 R 216594 CDS YP_001853278.1 183984987 6229310 complement(6092625..6093758) 1 NC_010612.1 hypothetical protein 6093758 6229310 MMAR_5019 Mycobacterium marinum M hypothetical protein YP_001853278.1 6092625 R 216594 CDS YP_001853279.1 183984988 6229311 6093996..6096605 1 NC_010612.1 function unknown, this enzyme catalyses the first and rate limiting step in de novo glutathione biosynthesis; glutamate--cysteine ligase, Gcs2 6096605 gcs2 6229311 gcs2 Mycobacterium marinum M glutamate--cysteine ligase, Gcs2 YP_001853279.1 6093996 D 216594 CDS YP_001853280.1 183984989 6229312 complement(6096592..6097635) 1 NC_010612.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 6097635 6229312 MMAR_5021 Mycobacterium marinum M 4-hydroxy-2-ketovalerate aldolase YP_001853280.1 6096592 R 216594 CDS YP_001853281.1 183984990 6229313 complement(6097632..6098558) 1 NC_010612.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 6098558 mhpF_1 6229313 mhpF_1 Mycobacterium marinum M acetaldehyde dehydrogenase YP_001853281.1 6097632 R 216594 CDS YP_001853282.1 183984991 6229314 complement(6098602..6099387) 1 NC_010612.1 function unknown; probably involved in cellular metabolism; 2-keto-4-pentenoate hydratase 6099387 6229314 MMAR_5023 Mycobacterium marinum M 2-keto-4-pentenoate hydratase YP_001853282.1 6098602 R 216594 CDS YP_001853283.1 183984992 6229315 6099462..6101165 1 NC_010612.1 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione; 3-ketosteroid-delta-1-dehydrogenase 6101165 6229315 MMAR_5024 Mycobacterium marinum M 3-ketosteroid-delta-1-dehydrogenase YP_001853283.1 6099462 D 216594 CDS YP_001853284.1 183984993 6229316 6101167..6102036 1 NC_010612.1 function unknown, probably involved in cellular metabolism; dehydratase 6102036 6229316 MMAR_5025 Mycobacterium marinum M dehydratase YP_001853284.1 6101167 D 216594 CDS YP_001853285.1 183984994 6229317 complement(6102124..6102969) 1 NC_010612.1 function unknown, contains restriction endonuclease- like superfamily domain; hypothetical protein 6102969 6229317 MMAR_5026 Mycobacterium marinum M hypothetical protein YP_001853285.1 6102124 R 216594 CDS YP_001853286.1 183984995 6229318 complement(6103100..6104260) 1 NC_010612.1 function unknown, supposed involvement in lipid metabolism; lipid-transfer protein 6104260 ltp2_1 6229318 ltp2_1 Mycobacterium marinum M lipid-transfer protein YP_001853286.1 6103100 R 216594 CDS YP_001853287.1 183984996 6229319 complement(6104260..6104661) 1 NC_010612.1 function unknown, potential role in lipid metabolism. contains thioesterase/thiol ester dehydrase- isomerase superfamily domain; hypothetical protein 6104661 6229319 MMAR_5028 Mycobacterium marinum M hypothetical protein YP_001853287.1 6104260 R 216594 CDS YP_001853288.1 183984997 6229320 complement(6104658..6105608) 1 NC_010612.1 function unknown, contains a predicted C-term nucleic-acid-binding protein; hypothetical protein 6105608 6229320 MMAR_5029 Mycobacterium marinum M hypothetical protein YP_001853288.1 6104658 R 216594 CDS YP_001853289.1 183984998 6229321 complement(6105605..6106768) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE29 6106768 fadE29 6229321 fadE29 Mycobacterium marinum M acyl-CoA dehydrogenase FadE29 YP_001853289.1 6105605 R 216594 CDS YP_001853290.1 183984999 6229322 complement(6106753..6107784) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE28 6107784 fadE28 6229322 fadE28 Mycobacterium marinum M acyl-CoA dehydrogenase FadE28 YP_001853290.1 6106753 R 216594 CDS YP_001853291.1 183985000 6229323 complement(6107802..6109055) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 125A7 Cyp125A7 6109055 cyp125A7 6229323 cyp125A7 Mycobacterium marinum M cytochrome P450 125A7 Cyp125A7 YP_001853291.1 6107802 R 216594 CDS YP_001853292.1 183985001 6229324 6109226..6110401 1 NC_010612.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 6110401 fadA5 6229324 fadA5 Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001853292.1 6109226 D 216594 CDS YP_001853293.1 183985002 6229325 6110409..6110795 1 NC_010612.1 hypothetical protein 6110795 6229325 MMAR_5034 Mycobacterium marinum M hypothetical protein YP_001853293.1 6110409 D 216594 CDS YP_001853294.1 183985003 6229326 6110859..6111314 1 NC_010612.1 function unknown; contains a FMN-binding split barrel domain. possible role in the electron-transfer pathway. the FMN-binding split barrel is related to the ferredoxin reductase-like FAD-binding domain. flavodoxins are an example of a group of proteins with a tightly bound flavin mononucleotide (FMN) that mediate electron transfer at low redox potential; hypothetical protein 6111314 6229326 MMAR_5035 Mycobacterium marinum M hypothetical protein YP_001853294.1 6110859 D 216594 CDS YP_001853295.1 183985004 6229327 complement(6111360..6112265) 1 NC_010612.1 function unknown, supposed involvement in cellular metabolism; short chain dehydrogenase 6112265 6229327 MMAR_5036 Mycobacterium marinum M short chain dehydrogenase YP_001853295.1 6111360 R 216594 CDS YP_001853296.1 183985005 6229328 complement(6112286..6113065) 1 NC_010612.1 function unknown, supposed involvement in cellular metabolism; short chain dehydrogenase 6113065 6229328 MMAR_5037 Mycobacterium marinum M short chain dehydrogenase YP_001853296.1 6112286 R 216594 CDS YP_001853297.1 183985006 6229329 complement(6113155..6115056) 1 NC_010612.1 PE-PGRS family protein 6115056 6229329 MMAR_5038 Mycobacterium marinum M PE-PGRS family protein YP_001853297.1 6113155 R 216594 CDS YP_001853298.1 183985007 6229330 6115378..6116121 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 6116121 echA20 6229330 echA20 Mycobacterium marinum M enoyl-CoA hydratase YP_001853298.1 6115378 D 216594 CDS YP_001853299.1 183985008 6229331 6116118..6116996 1 NC_010612.1 function unknown. possible subunit of a CoA- transferase, catalyzing the reversible of CoA from one carboxylic acid to another; CoA-transferase subunit alpha 6116996 6229331 MMAR_5040 Mycobacterium marinum M CoA-transferase subunit alpha YP_001853299.1 6116118 D 216594 CDS YP_001853300.1 183985009 6229332 6116993..6117736 1 NC_010612.1 function unknown. possible subunit of a CoA- transferase, catalyzing the reversible of CoA from one carboxylic acid to another; CoA-transferase subunit beta 6117736 6229332 MMAR_5041 Mycobacterium marinum M CoA-transferase subunit beta YP_001853300.1 6116993 D 216594 CDS YP_001853301.1 183985010 6229333 6117733..6118800 1 NC_010612.1 function unknown, members of this family catalyse the denitrification of a number of nitroalkanes using either fad or FMN as a cofactor; 2-nitropropane dioxygenase 6118800 6229333 MMAR_5042 Mycobacterium marinum M 2-nitropropane dioxygenase YP_001853301.1 6117733 D 216594 CDS YP_001853302.1 183985011 6229334 6118831..6120852 1 NC_010612.1 function unknown, c-terminus probably involved in electron transfer in one or several metabolic reactions; electron transfer protein FdxB 6120852 fdxB 6229334 fdxB Mycobacterium marinum M electron transfer protein FdxB YP_001853302.1 6118831 D 216594 CDS YP_001853303.1 183985012 6229335 complement(6120939..6125294) 1 NC_010612.1 PE-PGRS family protein 6125294 6229335 MMAR_5044 Mycobacterium marinum M PE-PGRS family protein YP_001853303.1 6120939 R 216594 CDS YP_001853304.1 183985013 6229336 complement(6125498..6126658) 1 NC_010612.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 6126658 fadA6_1 6229336 fadA6_1 Mycobacterium marinum M acetyl-CoA acetyltransferase YP_001853304.1 6125498 R 216594 CDS YP_001853305.1 183985014 6229337 complement(6126661..6127263) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 6127263 6229337 MMAR_5046 Mycobacterium marinum M TetR family transcriptional regulator YP_001853305.1 6126661 R 216594 CDS YP_001853306.1 183985015 6229338 6127439..6129052 1 NC_010612.1 PPE family protein 6129052 6229338 MMAR_5047 Mycobacterium marinum M PPE family protein YP_001853306.1 6127439 D 216594 CDS YP_001853307.1 183985016 6229339 complement(6129127..6129915) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; short chain dehydrogenase 6129915 6229339 MMAR_5048 Mycobacterium marinum M short chain dehydrogenase YP_001853307.1 6129127 R 216594 CDS YP_001853308.1 183985017 6229340 complement(6129912..6131060) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE30 6131060 fadE30 6229340 fadE30 Mycobacterium marinum M acyl-CoA dehydrogenase FadE30 YP_001853308.1 6129912 R 216594 CDS YP_001853309.1 183985018 6229341 6131131..6132654 1 NC_010612.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 6132654 fadD3 6229341 fadD3 Mycobacterium marinum M long-chain-fatty-acid--CoA ligase YP_001853309.1 6131131 D 216594 CDS YP_001853310.1 183985019 6229342 6132655..6133788 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE31 6133788 fadE31 6229342 fadE31 Mycobacterium marinum M acyl-CoA dehydrogenase FadE31 YP_001853310.1 6132655 D 216594 CDS YP_001853311.1 183985020 6229343 6133792..6134727 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE32 6134727 fadE32 6229343 fadE32 Mycobacterium marinum M acyl-CoA dehydrogenase FadE32 YP_001853311.1 6133792 D 216594 CDS YP_001853312.1 183985021 6229344 6134777..6135739 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE33 6135739 fadE33 6229344 fadE33 Mycobacterium marinum M acyl-CoA dehydrogenase FadE33 YP_001853312.1 6134777 D 216594 CDS YP_001853313.1 183985022 6229345 6135736..6136911 1 NC_010612.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 6136911 aspB 6229345 aspB Mycobacterium marinum M aspartate aminotransferase YP_001853313.1 6135736 D 216594 CDS YP_001853314.1 183985023 6229346 complement(6136925..6137767) 1 NC_010612.1 could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [catalytic activity: acetyl-CoA + arylamine = CoA + N- acetylarylamine]; arylamine N-acetyltransferase Nat 6137767 nat 6229346 nat Mycobacterium marinum M arylamine N-acetyltransferase Nat YP_001853314.1 6136925 R 216594 CDS YP_001853315.1 183985024 6229347 6137920..6138531 1 NC_010612.1 function unknown; hypothetical protein 6138531 6229347 MMAR_5056 Mycobacterium marinum M hypothetical protein YP_001853315.1 6137920 D 216594 CDS YP_001853316.1 183985025 6229348 6138831..6139376 1 NC_010612.1 function unknown, possibly involved in thiol:disulfide interchange. contains PS00013 prokaryotic membrane lipoprotein lipid attachment site, N-term signal pepitde sequence and PS00194 thioredoxin family active site; lipoprotein DsbF 6139376 dsbF 6229348 dsbF Mycobacterium marinum M lipoprotein DsbF YP_001853316.1 6138831 D 216594 CDS YP_001853317.1 183985026 6229349 6139373..6140260 1 NC_010612.1 hypothetical protein 6140260 6229349 MMAR_5058 Mycobacterium marinum M hypothetical protein YP_001853317.1 6139373 D 216594 CDS YP_001853318.1 183985027 6229350 complement(6140255..6141187) 1 NC_010612.1 function unknown, but domain identity suggests this protein may have metalloendopeptidase activity; peptidase M48 like- protein 6141187 6229350 MMAR_5059 Mycobacterium marinum M peptidase M48 like- protein YP_001853318.1 6140255 R 216594 CDS YP_001853319.1 183985028 6229351 complement(6141184..6141522) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulatory protein 6141522 6229351 MMAR_5060 Mycobacterium marinum M transcriptional regulatory protein YP_001853319.1 6141184 R 216594 CDS YP_001853320.1 183985029 6229352 6141711..6142118 1 NC_010612.1 hypothetical protein 6142118 6229352 MMAR_5061 Mycobacterium marinum M hypothetical protein YP_001853320.1 6141711 D 216594 CDS YP_001853321.1 183985030 6229353 complement(6142204..6142770) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidase 6142770 6229353 MMAR_5062 Mycobacterium marinum M oxidase YP_001853321.1 6142204 R 216594 CDS YP_001853322.1 183985031 6229354 complement(6142782..6143684) 1 NC_010612.1 involved in the degradation of biphenyl [catalytic activity: biphenyl-2,3-diol + O(2) = 2-hydroxy-6-OXO-6- phenylhexa-2,4-dienoate + H(2)O]; biphenyl-2,3-diol 1,2-dioxygenase 6143684 bphC 6229354 bphC Mycobacterium marinum M biphenyl-2,3-diol 1,2-dioxygenase YP_001853322.1 6142782 R 216594 CDS YP_001853323.1 183985032 6229355 complement(6143681..6144568) 1 NC_010612.1 involved in the degradation of biphenyl; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 6144568 bphD 6229355 bphD Mycobacterium marinum M 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD YP_001853323.1 6143681 R 216594 CDS YP_001853324.1 183985033 6229356 complement(6144568..6145752) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; acyl-CoA dehydrogenase 6145752 6229356 MMAR_5065 Mycobacterium marinum M acyl-CoA dehydrogenase YP_001853324.1 6144568 R 216594 CDS YP_001853325.1 183985034 6229357 6145946..6147022 1 NC_010612.1 may play a role in protection from oxidative (nitric oxide) and nitrosative stress. may also be involved in anaerobic metabolism. could have nitric oxide dioxygenase activity; flavodoxin reductase Hmp 6147022 hmp 6229357 hmp Mycobacterium marinum M flavodoxin reductase Hmp YP_001853325.1 6145946 D 216594 CDS YP_001853326.1 183985035 6229358 6147068..6147598 1 NC_010612.1 hypothetical protein 6147598 6229358 MMAR_5067 Mycobacterium marinum M hypothetical protein YP_001853326.1 6147068 D 216594 CDS YP_001853327.1 183985036 6229359 complement(6147614..6149749) 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE34 6149749 fadE34 6229359 fadE34 Mycobacterium marinum M acyl-CoA dehydrogenase FadE34 YP_001853327.1 6147614 R 216594 CDS YP_001853328.1 183985037 6229360 6150031..6150633 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 6150633 6229360 MMAR_5069 Mycobacterium marinum M TetR family transcriptional regulator YP_001853328.1 6150031 D 216594 CDS YP_001853329.1 183985038 6229361 complement(6150640..6151719) 1 NC_010612.1 involved in transcriptional mechanism; PurR family transcriptional regulator 6151719 6229361 MMAR_5070 Mycobacterium marinum M PurR family transcriptional regulator YP_001853329.1 6150640 R 216594 CDS YP_001853330.1 183985039 6229362 6151812..6152720 1 NC_010612.1 function unknown, domain identity suggests periplasmic solute binding protein, containing an ATP- binding cassette transport system; hypothetical protein 6152720 6229362 MMAR_5071 Mycobacterium marinum M hypothetical protein YP_001853330.1 6151812 D 216594 CDS YP_001853331.1 183985040 6229363 6152729..6153547 1 NC_010612.1 function unknown, part of a binding-protein- dependent ABC transport system; ATPase component of an ABC-type transport system 6153547 6229363 MMAR_5072 Mycobacterium marinum M ATPase component of an ABC-type transport system YP_001853331.1 6152729 D 216594 CDS YP_001853332.1 183985041 6229364 6153544..6154395 1 NC_010612.1 part of an ABC transport system; permease of an ABC-type transporter 6154395 6229364 MMAR_5073 Mycobacterium marinum M permease of an ABC-type transporter YP_001853332.1 6153544 D 216594 CDS YP_001853333.1 183985042 6229365 6154482..6155198 1 NC_010612.1 lipoprotein LppH 6155198 lppH 6229365 lppH Mycobacterium marinum M lipoprotein LppH YP_001853333.1 6154482 D 216594 CDS YP_001853334.1 183985043 6229366 6155213..6155962 1 NC_010612.1 lipoprotein 6155962 6229366 MMAR_5075 Mycobacterium marinum M lipoprotein YP_001853334.1 6155213 D 216594 CDS YP_001853335.1 183985044 6229367 6155981..6156739 1 NC_010612.1 function unknown, the lam locus of aspergillus nidulans consists of two divergently transcribed genes, lama and LamB, involved in the utilization of lactams such as 2-pyrrolidinone. both genes are under the control of the positive regulatory gene AmdR and are subject to carbon and nitrogen metabolite repression. the exact molecular function of the proteins in this family is unknown; LamB/YcsF family protein 6156739 lamB 6229367 lamB Mycobacterium marinum M LamB/YcsF family protein YP_001853335.1 6155981 D 216594 CDS YP_001853336.1 183985045 6229368 6156739..6157659 1 NC_010612.1 hypothetical protein 6157659 6229368 MMAR_5077 Mycobacterium marinum M hypothetical protein YP_001853336.1 6156739 D 216594 CDS YP_001853337.1 183985046 6229369 6157682..6158923 1 NC_010612.1 thought to be involved in transport of arsenic across the membrane (export): arsenic resistance by an export mechanism. form the channel of an arsenite pump responsible for the translocation of the substrate across the membrane; arsenical pump integral membrane protein ArsB2 6158923 arsB2 6229369 arsB2 Mycobacterium marinum M arsenical pump integral membrane protein ArsB2 YP_001853337.1 6157682 D 216594 CDS YP_001853338.1 183985047 6229370 complement(6158946..6159878) 1 NC_010612.1 function unknown role in tRNA and rRNA base modification by methylation; tRNA/rRNA methyltransferase 6159878 6229370 MMAR_5079 Mycobacterium marinum M tRNA/rRNA methyltransferase YP_001853338.1 6158946 R 216594 CDS YP_001853339.1 183985048 6229371 complement(6159879..6161285) 1 NC_010612.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 6161285 cysS 6229371 cysS Mycobacterium marinum M cysteinyl-tRNA synthetase YP_001853339.1 6159879 R 216594 CDS YP_001853340.1 183985049 6229372 complement(6161343..6161840) 1 NC_010612.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 6161840 ispF 6229372 ispF Mycobacterium marinum M 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_001853340.1 6161343 R 216594 CDS YP_001853341.1 183985050 6229373 complement(6161837..6162520) 1 NC_010612.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 6162520 ispD 6229373 ispD Mycobacterium marinum M 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_001853341.1 6161837 R 216594 CDS YP_001853342.1 183985051 6229374 complement(6162537..6163025) 1 NC_010612.1 function unknown role in regulation; transcriptional regulatory protein 6163025 6229374 MMAR_5083 Mycobacterium marinum M transcriptional regulatory protein YP_001853342.1 6162537 R 216594 CDS YP_001853343.1 183985052 6229375 6163468..6164025 1 NC_010612.1 lipoprotein LpqE 6164025 lpqE 6229375 lpqE Mycobacterium marinum M lipoprotein LpqE YP_001853343.1 6163468 D 216594 CDS YP_001853344.1 183985053 6229376 6164067..6165542 1 NC_010612.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 6165542 radA 6229376 radA Mycobacterium marinum M DNA repair protein RadA YP_001853344.1 6164067 D 216594 CDS YP_001853345.1 183985054 6229377 6165561..6166637 1 NC_010612.1 non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair; DNA integrity scanning protein DisA 6166637 6229377 MMAR_5086 Mycobacterium marinum M DNA integrity scanning protein DisA YP_001853345.1 6165561 D 216594 CDS YP_001853346.1 183985055 6229378 complement(6166649..6167470) 1 NC_010612.1 hypothetical protein 6167470 6229378 MMAR_5087 Mycobacterium marinum M hypothetical protein YP_001853346.1 6166649 R 216594 CDS YP_001853347.1 183985056 6229379 complement(6167560..6168186) 1 NC_010612.1 catalyzes the reversible hydratation of carbon dioxide [catalytic activity: H(2)CO(3) = CO(2) + H(2)O]; carbonic anhydrase 6168186 6229379 MMAR_5088 Mycobacterium marinum M carbonic anhydrase YP_001853347.1 6167560 R 216594 CDS YP_001853348.1 183985057 6229380 6168203..6169087 1 NC_010612.1 involved in base excision repair. removes adenine mispaired with 8-OXOG. may repair a.G and a.C mismatches by adenine excision; adenine glycosylase MutY 6169087 mutY 6229380 mutY Mycobacterium marinum M adenine glycosylase MutY YP_001853348.1 6168203 D 216594 CDS YP_001853349.1 183985058 6229381 complement(6169095..6169862) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hydrolase 6169862 6229381 MMAR_5090 Mycobacterium marinum M hydrolase YP_001853349.1 6169095 R 216594 CDS YP_001853350.1 183985059 6229382 6169918..6170235 1 NC_010612.1 TB11.2; hypothetical protein 6170235 6229382 MMAR_5091 Mycobacterium marinum M hypothetical protein YP_001853350.1 6169918 D 216594 CDS YP_001853351.1 183985060 6229383 6170210..6171580 1 NC_010612.1 lipoprotein LpqF 6171580 lpqF 6229383 lpqF Mycobacterium marinum M lipoprotein LpqF YP_001853351.1 6170210 D 216594 CDS YP_001853352.1 183985061 6229384 complement(6171438..6172400) 1 NC_010612.1 transfers mannose from GDP-mannose to all endogenous polyprenol-phosphates; polyprenol-monophosphomannose synthase Ppm1_2 6172400 ppm1_2 6229384 ppm1_2 Mycobacterium marinum M polyprenol-monophosphomannose synthase Ppm1_2 YP_001853352.1 6171438 R 216594 CDS YP_001853353.1 183985062 6229385 complement(6172397..6174019) 1 NC_010612.1 thought to be involved in a transport system across the membrane (perhaps drug transport): responsible for the translocation of the substrate across the membrane; integral membrane transport protein 6174019 6229385 MMAR_5094 Mycobacterium marinum M integral membrane transport protein YP_001853353.1 6172397 R 216594 CDS YP_001853354.1 183985063 6229386 complement(6174030..6175070) 1 NC_010612.1 involved in the biosynthesis of membrane ether- linked lipids. catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [catalytic activity1: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate] [catalytic activity2: geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans- farnesyl diphosphate] [catalytic activity3: trans-trans- farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate]; multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 6175070 idsA1 6229386 idsA1 Mycobacterium marinum M multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 YP_001853354.1 6174030 R 216594 CDS YP_001853355.1 183985064 6229387 complement(6175296..6175829) 1 NC_010612.1 may be involved in the catalysis of both the synthesis and the degradation of fructose-2,6- bisphosphate. beta-D-fructose 2,6-bisphosphate + H(2)O <=> D-fructose 6-phosphate + phosphate; fructose-2,6-bisphosphatase GpmB 6175829 gpmB 6229387 gpmB Mycobacterium marinum M fructose-2,6-bisphosphatase GpmB YP_001853355.1 6175296 R 216594 CDS YP_001853356.1 183985065 6229388 complement(6175837..6176628) 1 NC_010612.1 hypothetical protein 6176628 6229388 MMAR_5097 Mycobacterium marinum M hypothetical protein YP_001853356.1 6175837 R 216594 CDS YP_001853357.1 183985066 6229389 complement(6176619..6176828) 1 NC_010612.1 hypothetical protein 6176828 6229389 MMAR_5098 Mycobacterium marinum M hypothetical protein YP_001853357.1 6176619 R 216594 CDS YP_001853358.1 183985067 6229390 complement(6177005..6178375) 1 NC_010612.1 PE-PGRS family protein 6178375 6229390 MMAR_5099 Mycobacterium marinum M PE-PGRS family protein YP_001853358.1 6177005 R 216594 CDS YP_001853359.1 183985068 6229391 complement(6178578..6181124) 1 NC_010612.1 hydrolyses proteins in presence of ATP. may interact with a ClpP-like protease involved in degradation of denatured proteins; ATP-dependent protease ATP-binding subunit ClpC1 6181124 clpC1 6229391 clpC1 Mycobacterium marinum M ATP-dependent protease ATP-binding subunit ClpC1 YP_001853359.1 6178578 R 216594 CDS YP_001853360.1 183985069 6229392 complement(6181502..6181843) 1 NC_010612.1 dominant T-cell antigen and may stimulate lymphocyte proliferation; iron-regulated Lsr2 protein 6181843 lsr2 6229392 lsr2 Mycobacterium marinum M iron-regulated Lsr2 protein YP_001853360.1 6181502 R 216594 CDS YP_001853361.1 183985070 6229393 complement(6181958..6183454) 1 NC_010612.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 6183454 lysS 6229393 lysS Mycobacterium marinum M lysyl-tRNA synthetase YP_001853361.1 6181958 R 216594 CDS YP_001853362.1 183985071 6229394 complement(6183576..6184394) 1 NC_010612.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 6184394 6229394 MMAR_5103 Mycobacterium marinum M pantothenate kinase YP_001853362.1 6183576 R 216594 CDS YP_001853363.1 183985072 6229395 complement(6184397..6184828) 1 NC_010612.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 6184828 panD 6229395 panD Mycobacterium marinum M aspartate alpha-decarboxylase YP_001853363.1 6184397 R 216594 CDS YP_001853364.1 183985073 6229396 complement(6184828..6185775) 1 NC_010612.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 6185775 panC 6229396 panC Mycobacterium marinum M pantoate--beta-alanine ligase YP_001853364.1 6184828 R 216594 CDS YP_001853365.1 183985074 6229397 complement(6185772..6186698) 1 NC_010612.1 function unknown contains NAD(P)-binding Rossmann- fold superfamily domains; hypothetical protein 6186698 6229397 MMAR_5106 Mycobacterium marinum M hypothetical protein YP_001853365.1 6185772 R 216594 CDS YP_001853366.1 183985075 6229398 complement(6186786..6188138) 1 NC_010612.1 transmembrane protein rich in alanine, arginine and proline 6188138 6229398 MMAR_5107 Mycobacterium marinum M transmembrane protein rich in alanine, arginine and proline YP_001853366.1 6186786 R 216594 CDS YP_001853367.1 183985076 6229399 complement(6188250..6188726) 1 NC_010612.1 hypothetical protein 6188726 6229399 MMAR_5108 Mycobacterium marinum M hypothetical protein YP_001853367.1 6188250 R 216594 CDS YP_001853368.1 183985077 6229400 complement(6188726..6189253) 1 NC_010612.1 involved in dihydrofolate biosynthesis (at the first step) [catalytic activity: ATP + 2-amino-4-hydroxy-6- hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8- dihydro-4-hydroxy-6-(diphosphooxymethyl)pteri di ne]; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 6189253 folK 6229400 folK Mycobacterium marinum M 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_001853368.1 6188726 R 216594 CDS YP_001853369.1 183985078 6229401 complement(6189250..6189651) 1 NC_010612.1 involved in folate biosynthesis. catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8- dihydropterin (by similarity) [catalytic activity: 2-amino- 4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7, 8- dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine + glycolaldehyde]; dihydroneopterin aldolase FolB 6189651 folB 6229401 folB Mycobacterium marinum M dihydroneopterin aldolase FolB YP_001853369.1 6189250 R 216594 CDS YP_001853370.1 183985079 6229402 complement(6189644..6190486) 1 NC_010612.1 involved in dihydrofolate biosynthesis (at the second step). catalyzes the formation of the immediate precursor of folic acid. it is implicated in resistance to sulfonamide [catalytic activity: 2-amino-4-hydroxy-6- hydroxymethyl-7,8-dihydropteridine diphosphate + 4- aminobenzoate = pyrophosphate + dihydropteroate]; dihydropteroate synthase 1 FolP1 6190486 folP1 6229402 folP1 Mycobacterium marinum M dihydropteroate synthase 1 FolP1 YP_001853370.1 6189644 R 216594 CDS YP_001853371.1 183985080 6229403 complement(6190483..6191091) 1 NC_010612.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 6191091 folE 6229403 folE Mycobacterium marinum M GTP cyclohydrolase I YP_001853371.1 6190483 R 216594 CDS YP_001853372.1 183985081 6229404 complement(6191108..6193348) 1 NC_010612.1 thought to act as an ATP-dependent zinc metallopeptidase, with ATPase and proteolytic activities. probably has a regulatory role in stress response and specific proteins secretion for adaptation to host environment; membrane-bound protease FtsH 6193348 ftsH 6229404 ftsH Mycobacterium marinum M membrane-bound protease FtsH YP_001853372.1 6191108 R 216594 CDS YP_001853373.1 183985082 6229405 6193588..6194556 1 NC_010612.1 biotransformation enzyme that catalyzes the hydrolysis of epoxides (alkene oxides, oxiranes) and Arene oxides to less reactive and more water soluble dihydrodiols by the trans addition of water. thought to be involved in detoxification reactions following oxidative damage to lipids [catalytic activity: an epoxide + H(2)O = a glycol]; epoxide hydrolase EphA 6194556 ephA 6229405 ephA Mycobacterium marinum M epoxide hydrolase EphA YP_001853373.1 6193588 D 216594 CDS YP_001853374.1 183985083 6229406 6194553..6195743 1 NC_010612.1 monooxygenase 6195743 6229406 MMAR_5115 Mycobacterium marinum M monooxygenase YP_001853374.1 6194553 D 216594 CDS YP_001853375.1 183985084 6229407 6195743..6196756 1 NC_010612.1 function unknown; probably involved in cellular metabolism; dehydrogenase 6196756 6229407 MMAR_5116 Mycobacterium marinum M dehydrogenase YP_001853375.1 6195743 D 216594 CDS YP_001853376.1 183985085 6229408 complement(6196788..6198044) 1 NC_010612.1 PPE family protein 6198044 6229408 MMAR_5117 Mycobacterium marinum M PPE family protein YP_001853376.1 6196788 R 216594 CDS YP_001853377.1 183985086 6229409 complement(6198057..6198356) 1 NC_010612.1 PE family protein 6198356 6229409 MMAR_5118 Mycobacterium marinum M PE family protein YP_001853377.1 6198057 R 216594 CDS YP_001853378.1 183985087 6229410 complement(6199053..6199337) 1 NC_010612.1 EsaT-6 like protein EsxN_2 6199337 esxN_2 6229410 esxN_2 Mycobacterium marinum M EsaT-6 like protein EsxN_2 YP_001853378.1 6199053 R 216594 CDS YP_001853379.1 183985088 6229411 complement(6199376..6199672) 1 NC_010612.1 EsaT-6 like protein EsxP 6199672 esxP_1 6229411 esxP_1 Mycobacterium marinum M EsaT-6 like protein EsxP YP_001853379.1 6199376 R 216594 CDS YP_001853380.1 183985089 6229412 complement(6199804..6201045) 1 NC_010612.1 PPE family protein 6201045 6229412 MMAR_5121 Mycobacterium marinum M PPE family protein YP_001853380.1 6199804 R 216594 CDS YP_001853381.1 183985090 6229413 complement(6201059..6201358) 1 NC_010612.1 PE family protein 6201358 6229413 MMAR_5122 Mycobacterium marinum M PE family protein YP_001853381.1 6201059 R 216594 CDS YP_001853382.1 183985091 6229414 6202176..6202922 1 NC_010612.1 lipoprotein LpqG 6202922 lpqG 6229414 lpqG Mycobacterium marinum M lipoprotein LpqG YP_001853382.1 6202176 D 216594 CDS YP_001853383.1 183985092 6229415 complement(6202948..6203556) 1 NC_010612.1 involved in purine salvage [catalytic activity: imp + pyrophosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate (guanine can replace hypoxanthine to produce GMP)]; hypoxanthine-guanine phosphoribosyltransferase Hpt 6203556 hpt 6229415 hpt Mycobacterium marinum M hypoxanthine-guanine phosphoribosyltransferase Hpt YP_001853383.1 6202948 R 216594 CDS YP_001853384.1 183985093 6229416 complement(6203610..6204581) 1 NC_010612.1 predicted ATPase of the PP-loop superfamily implicated in cell cycle control; cell cycle protein MesJ 6204581 mesJ 6229416 mesJ Mycobacterium marinum M cell cycle protein MesJ YP_001853384.1 6203610 R 216594 CDS YP_001853385.1 183985094 6229417 complement(6204560..6205618) 1 NC_010612.1 hypothetical protein 6205618 6229417 MMAR_5126 Mycobacterium marinum M hypothetical protein YP_001853385.1 6204560 R 216594 CDS YP_001853386.1 183985095 6229418 complement(6205615..6207000) 1 NC_010612.1 involved in peptidoglycan synthesis (at final stages). hydrolyzes the bound D-alanyl-D-alanine [catalytic activity: D-alanyl-D-alanine + H(2)O = 2 D- alanine]; D-alanyl-D-alanine carboxypeptidase 6207000 dacB1 6229418 dacB1 Mycobacterium marinum M D-alanyl-D-alanine carboxypeptidase YP_001853386.1 6205615 R 216594 CDS YP_001853387.1 183985096 6229419 6207141..6207629 1 NC_010612.1 involved in the function of cellular bioenergetics [catalytic activity: pyrophosphate + H(2)O = 2 orthophosphate]; inorganic pyrophosphatase Ppa 6207629 ppa 6229419 ppa Mycobacterium marinum M inorganic pyrophosphatase Ppa YP_001853387.1 6207141 D 216594 CDS YP_001853388.1 183985097 6229420 complement(6207638..6208714) 1 NC_010612.1 hypothetical protein 6208714 6229420 MMAR_5129 Mycobacterium marinum M hypothetical protein YP_001853388.1 6207638 R 216594 CDS YP_001853389.1 183985098 6229421 6208879..6210153 1 NC_010612.1 hypothetical protein 6210153 6229421 MMAR_5130 Mycobacterium marinum M hypothetical protein YP_001853389.1 6208879 D 216594 CDS YP_001853390.1 183985099 6229422 6210201..6210902 1 NC_010612.1 function unknown, the domain detected in this CDS is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family protein 6210902 6229422 MMAR_5131 Mycobacterium marinum M glycosyl transferase family protein YP_001853390.1 6210201 D 216594 CDS YP_001853391.1 183985100 6229423 6210899..6211240 1 NC_010612.1 hypothetical protein 6211240 6229423 MMAR_5132 Mycobacterium marinum M hypothetical protein YP_001853391.1 6210899 D 216594 CDS YP_001853392.1 183985101 6229424 complement(6211256..6212200) 1 NC_010612.1 involved in galactofuranosyl biosynthesis: converts UDO-GlcP to UDP-GalP [catalytic activity: UDP- glucopyranose = UDP-galactopyranose]; UDP-glucose 4-epimerase GalE1 6212200 galE1 6229424 galE1 Mycobacterium marinum M UDP-glucose 4-epimerase GalE1 YP_001853392.1 6211256 R 216594 CDS YP_001853393.1 183985102 6229425 6212233..6214017 1 NC_010612.1 hypothetical protein 6214017 6229425 MMAR_5134 Mycobacterium marinum M hypothetical protein YP_001853393.1 6212233 D 216594 CDS YP_001853394.1 183985103 6229426 6214159..6216204 1 NC_010612.1 PE-PGRS family protein 6216204 6229426 MMAR_5135 Mycobacterium marinum M PE-PGRS family protein YP_001853394.1 6214159 D 216594 CDS YP_001853395.1 183985104 6229428 complement(6216373..6217590) 1 NC_010612.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 6217590 6229428 MMAR_5136 Mycobacterium marinum M DNA polymerase III subunit delta' YP_001853395.1 6216373 R 216594 CDS YP_001853396.1 183985105 6229429 6217734..6219323 1 NC_010612.1 C-term contains an adenylyl/guanylyl cyclase domain. may catalyze the formation of cyclic AMP/GMP from ATP/GTP; adenylate cyclase 6219323 6229429 MMAR_5137 Mycobacterium marinum M adenylate cyclase YP_001853396.1 6217734 D 216594 CDS YP_001853397.1 183985106 6229430 complement(6219334..6222138) 1 NC_010612.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 6222138 topA 6229430 topA Mycobacterium marinum M DNA topoisomerase I YP_001853397.1 6219334 R 216594 CDS YP_001853398.1 183985107 6229431 complement(6222342..6222920) 1 NC_010612.1 hypothetical protein 6222920 6229431 MMAR_5139 Mycobacterium marinum M hypothetical protein YP_001853398.1 6222342 R 216594 CDS YP_001853399.1 183985108 6229432 complement(6223065..6223268) 1 NC_010612.1 possibly involved in cold acclimatization processes (the production of the protein is supposed predominantly induced at low temperatures); cold-shock protein 6223268 cspA_1 6229432 cspA_1 Mycobacterium marinum M cold-shock protein YP_001853399.1 6223065 R 216594 CDS YP_001853400.1 183985109 6229433 6223517..6225832 1 NC_010612.1 function unknown. helicases are involved in unwinding nucleic acids. the DeaD box helicases are involved in various aspects of RNA metabolism; DEAD/DEAH box helicase 6225832 6229433 MMAR_5141 Mycobacterium marinum M DEAD/DEAH box helicase YP_001853400.1 6223517 D 216594 CDS YP_001853401.1 183985110 6229434 6226324..6227355 1 NC_010612.1 hypothetical protein 6227355 6229434 MMAR_5142 Mycobacterium marinum M hypothetical protein YP_001853401.1 6226324 D 216594 CDS YP_001853402.1 183985111 6229435 complement(6227364..6227687) 1 NC_010612.1 hypothetical protein 6227687 6229435 MMAR_5143 Mycobacterium marinum M hypothetical protein YP_001853402.1 6227364 R 216594 CDS YP_001853403.1 183985112 6229436 complement(6227719..6227985) 1 NC_010612.1 hypothetical protein 6227985 6229436 MMAR_5577 Mycobacterium marinum M hypothetical protein YP_001853403.1 6227719 R 216594 CDS YP_001853404.1 183985113 6229437 complement(6228042..6228242) 1 NC_010612.1 hypothetical protein 6228242 6229437 MMAR_5144 Mycobacterium marinum M hypothetical protein YP_001853404.1 6228042 R 216594 CDS YP_001853405.1 183985114 6229438 complement(6228267..6228869) 1 NC_010612.1 hypothetical protein 6228869 6229438 MMAR_5145 Mycobacterium marinum M hypothetical protein YP_001853405.1 6228267 R 216594 CDS YP_001853406.1 183985115 6229439 complement(6228895..6229698) 1 NC_010612.1 function unknown, contains domain identity to Flp pilus assembly protein TadB; hypothetical protein 6229698 6229439 MMAR_5146 Mycobacterium marinum M hypothetical protein YP_001853406.1 6228895 R 216594 CDS YP_001853407.1 183985116 6229440 complement(6229695..6230864) 1 NC_010612.1 function unknown, contains domain identity with Flp pilus assembly protein, ATPase CpaF; hypothetical protein 6230864 6229440 MMAR_5147 Mycobacterium marinum M hypothetical protein YP_001853407.1 6229695 R 216594 CDS YP_001853408.1 183985117 6229441 complement(6230861..6231970) 1 NC_010612.1 function unknown, has a P-loop containing nucleoside triphosphate hydrolase superfamily domain; hypothetical protein 6231970 6229441 MMAR_5148 Mycobacterium marinum M hypothetical protein YP_001853408.1 6230861 R 216594 CDS YP_001853409.1 183985118 6229442 6232446..6233303 1 NC_010612.1 phosphoserine + H(2)O <=> serine + phosphate; phosphoserine phosphatase SerB 6233303 serB 6229442 serB Mycobacterium marinum M phosphoserine phosphatase SerB YP_001853409.1 6232446 D 216594 CDS YP_001853410.1 183985119 6229443 complement(6233429..6233743) 1 NC_010612.1 hypothetical protein 6233743 6229443 MMAR_5556 Mycobacterium marinum M hypothetical protein YP_001853410.1 6233429 R 216594 CDS YP_001853411.1 183985120 6229444 complement(6233796..6234566) 1 NC_010612.1 hypothetical protein 6234566 6229444 MMAR_5150 Mycobacterium marinum M hypothetical protein YP_001853411.1 6233796 R 216594 CDS YP_001853412.1 183985121 6229445 complement(6234578..6236233) 1 NC_010612.1 involved in active transport of dipeptides across the membrane (import). responsible for energy coupling to the transport system; dipeptide-transport ATP-binding protein ABC transporter DppD 6236233 dppD 6229445 dppD Mycobacterium marinum M dipeptide-transport ATP-binding protein ABC transporter DppD YP_001853412.1 6234578 R 216594 CDS YP_001853413.1 183985122 6229446 complement(6236230..6237093) 1 NC_010612.1 involved in active transport of dipeptide across the membrane (import). responsible for the translocation of the substrate across the membrane; dipeptide-transport integral membrane protein ABC transporter DppC 6237093 dppC 6229446 dppC Mycobacterium marinum M dipeptide-transport integral membrane protein ABC transporter DppC YP_001853413.1 6236230 R 216594 CDS YP_001853414.1 183985123 6229447 complement(6237086..6238012) 1 NC_010612.1 involved in active transport of dipeptide across the membrane (import). responsible for the translocation of the substrate across the membrane; dipeptide-transport integral membrane protein ABC transporter DppB 6238012 dppB 6229447 dppB Mycobacterium marinum M dipeptide-transport integral membrane protein ABC transporter DppB YP_001853414.1 6237086 R 216594 CDS YP_001853415.1 183985124 6229448 complement(6238014..6239633) 1 NC_010612.1 thought to be involved in active transport of dipeptide across the membrane (import); periplasmic dipeptide-binding lipoprotein DppA 6239633 dppA 6229448 dppA Mycobacterium marinum M periplasmic dipeptide-binding lipoprotein DppA YP_001853415.1 6238014 R 216594 CDS YP_001853416.1 183985125 6229449 6239844..6241799 1 NC_010612.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 6241799 acs 6229449 acs Mycobacterium marinum M acetyl-CoA synthetase YP_001853416.1 6239844 D 216594 CDS YP_001853417.1 183985126 6229450 complement(6241808..6242506) 1 NC_010612.1 function unknown, domain identity suggests peptidase, trypsin-like serine or cysteine protease. contains peptidase S1B, active site; hypothetical protein 6242506 6229450 MMAR_5156 Mycobacterium marinum M hypothetical protein YP_001853417.1 6241808 R 216594 CDS YP_001853418.1 183985127 6229451 6242732..6243250 1 NC_010612.1 hypothetical protein 6243250 6229451 MMAR_5157 Mycobacterium marinum M hypothetical protein YP_001853418.1 6242732 D 216594 CDS YP_001853419.1 183985128 6229452 6243251..6244216 1 NC_010612.1 thought to be involved in detoxification reactions following oxidative damage to lipids. biotransformation enzyme that catalyzes the hydrolysis of epoxides: aromatic hydrocarbons catabolism [catalytic activity: an epoxide + H(2)O = a glycol]; epoxide hydrolase EphE 6244216 ephE 6229452 ephE Mycobacterium marinum M epoxide hydrolase EphE YP_001853419.1 6243251 D 216594 CDS YP_001853420.1 183985129 6229453 complement(6244209..6245411) 1 NC_010612.1 function unknown, hydrolyses of peptides and/or proteins (possibly cleaved preferentially after serine residue). contains peptidase S1B, active site; membrane-associated serine protease 6245411 6229453 MMAR_5159 Mycobacterium marinum M membrane-associated serine protease YP_001853420.1 6244209 R 216594 CDS YP_001853421.1 183985130 6229454 complement(6245408..6246226) 1 NC_010612.1 function unknown: contains a NUDIX domain; hypothetical protein 6246226 6229454 MMAR_5160 Mycobacterium marinum M hypothetical protein YP_001853421.1 6245408 R 216594 CDS YP_001853422.1 183985131 6229455 complement(6246223..6246876) 1 NC_010612.1 function unknown, contains a N-term thioredoxin domain. may serve as a general protein disulphide oxidoreductase; membrane-anchored thioredoxin-like protein 6246876 6229455 MMAR_5161 Mycobacterium marinum M membrane-anchored thioredoxin-like protein YP_001853422.1 6246223 R 216594 CDS YP_001853423.1 183985132 6229456 complement(6246887..6247669) 1 NC_010612.1 has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. incises damaged DNA at cytosines, thymines and guanines. acts on a damaged strand (oxidized pyrimidines), 5' from the damaged site [catalytic activity: endonucleolytic cleavage near apurinic or apyrimidinic sites to products with 5'-phosphate]; endonuclease III Nth 6247669 nth 6229456 nth Mycobacterium marinum M endonuclease III Nth YP_001853423.1 6246887 R 216594 CDS YP_001853424.1 183985133 6229457 6247741..6248109 1 NC_010612.1 hypothetical protein 6248109 6229457 MMAR_5163 Mycobacterium marinum M hypothetical protein YP_001853424.1 6247741 D 216594 CDS YP_001853425.1 183985134 6229458 6248208..6248882 1 NC_010612.1 involved in transcriptional mechanism; regulatory protein 6248882 6229458 MMAR_5164 Mycobacterium marinum M regulatory protein YP_001853425.1 6248208 D 216594 CDS YP_001853426.1 183985135 6229459 complement(6248879..6249685) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hypothetical protein 6249685 6229459 MMAR_5165 Mycobacterium marinum M hypothetical protein YP_001853426.1 6248879 R 216594 CDS YP_001853427.1 183985136 6229460 complement(6249691..6250146) 1 NC_010612.1 function unknown, this endoribonuclease domain is active on single-stranded mRNA and inhibits protein synthesis by cleavage of mRNA; hypothetical protein 6250146 6229460 MMAR_5166 Mycobacterium marinum M hypothetical protein YP_001853427.1 6249691 R 216594 CDS YP_001853428.1 183985137 6229461 complement(6250168..6250329) 1 NC_010612.1 hypothetical protein 6250329 6229461 MMAR_5167 Mycobacterium marinum M hypothetical protein YP_001853428.1 6250168 R 216594 CDS YP_001853429.1 183985138 6229462 6250406..6251428 1 NC_010612.1 function unknown, may catalyze the extrusion of undeterminated anions [catalytic activity: ATP + H(2)O + undeterminated anion(in) = ADP + phosphate + undeterminated anion(out)]; anion transporter ATPase 6251428 6229462 MMAR_5168 Mycobacterium marinum M anion transporter ATPase YP_001853429.1 6250406 D 216594 CDS YP_001853430.1 183985139 6229463 6251425..6252585 1 NC_010612.1 anion-transporting ATPase; supposed catalyzes the extrusion of undeterminated anions [catalytic activity: ATP + H(2)O + undeterminated anion(in) = ADP + phosphate + undeterminated anion(out)]; anion transporter ATPase 6252585 6229463 MMAR_5169 Mycobacterium marinum M anion transporter ATPase YP_001853430.1 6251425 D 216594 CDS YP_001853431.1 183985140 6229464 complement(6252734..6253084) 1 NC_010612.1 involved in a transcriptional mechanism; transcriptional regulatory protein Whib-like WhiB4 6253084 whiB4 6229464 whiB4 Mycobacterium marinum M transcriptional regulatory protein Whib-like WhiB4 YP_001853431.1 6252734 R 216594 CDS YP_001853432.1 183985141 6229465 6253445..6255856 1 NC_010612.1 involved in peptidoglycan synthesis (at the final stages), cell wall formation. synthesis of cross-linked peptidoglycan from the lipid intermediates. the enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits); bifunctional membrane-associated penicillin- binding protein 1A/1B PonA2 6255856 ponA2 6229465 ponA2 Mycobacterium marinum M bifunctional membrane-associated penicillin- binding protein 1A/1B PonA2 YP_001853432.1 6253445 D 216594 CDS YP_001853433.1 183985142 6229466 6255923..6256936 1 NC_010612.1 function unknown, contains metallophosphoesterase domain; hypothetical protein 6256936 6229466 MMAR_5172 Mycobacterium marinum M hypothetical protein YP_001853433.1 6255923 D 216594 CDS YP_001853434.1 183985143 6229467 6256933..6258039 1 NC_010612.1 function unknown, probably involved in cellular metabolism. reaction catalysed: O(3)-acetyl-L-serine + H(2)S <=> L-cysteine + acetate; cysteine synthase 6258039 cysK 6229467 cysK Mycobacterium marinum M cysteine synthase YP_001853434.1 6256933 D 216594 CDS YP_001853435.1 183985144 6229469 complement(6258210..6258461) 1 NC_010612.1 hypothetical protein 6258461 6229469 MMAR_5174 Mycobacterium marinum M hypothetical protein YP_001853435.1 6258210 R 216594 CDS YP_001853436.1 183985145 6229470 complement(6258532..6259902) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 137A2 Cyp137A2 6259902 cyp137A2 6229470 cyp137A2 Mycobacterium marinum M cytochrome P450 137A2 Cyp137A2 YP_001853436.1 6258532 R 216594 CDS YP_001853437.1 183985146 6229471 complement(6259942..6260253) 1 NC_010612.1 hypothetical protein 6260253 6229471 MMAR_5176 Mycobacterium marinum M hypothetical protein YP_001853437.1 6259942 R 216594 CDS YP_001853438.1 183985147 6229472 complement(6260343..6260603) 1 NC_010612.1 hypothetical protein 6260603 6229472 MMAR_5177 Mycobacterium marinum M hypothetical protein YP_001853438.1 6260343 R 216594 CDS YP_001853439.1 183985148 6229473 complement(6260744..6261343) 1 NC_010612.1 function unknown; contains pas domain. this is usually associated with the input domain of a histidine kinase, or a sensor protein that regulates a histidine kinase; putative response regulatory protein 6261343 6229473 MMAR_5178 Mycobacterium marinum M putative response regulatory protein YP_001853439.1 6260744 R 216594 CDS YP_001853440.1 183985149 6229474 complement(6261634..6262143) 1 NC_010612.1 hypothetical protein 6262143 6229474 MMAR_5180 Mycobacterium marinum M hypothetical protein YP_001853440.1 6261634 R 216594 CDS YP_001853441.1 183985150 6229475 complement(6262215..6262583) 1 NC_010612.1 function unknown; potential role in regulation of transcription; anti-anti-sigma regulatory factor 6262583 6229475 MMAR_5181 Mycobacterium marinum M anti-anti-sigma regulatory factor YP_001853441.1 6262215 R 216594 CDS YP_001853442.1 183985151 6229476 6262743..6263639 1 NC_010612.1 function unknown; potential role in regulation of transcription; anti-anti-sigma regulatory factor 6263639 6229476 MMAR_5182 Mycobacterium marinum M anti-anti-sigma regulatory factor YP_001853442.1 6262743 D 216594 CDS YP_001853443.1 183985152 6229477 6263671..6264060 1 NC_010612.1 function unknown; contains an anti-anti-sigma regulatory factor domain. may have a role in a signal transduction mechanism; hypothetical protein 6264060 6229477 MMAR_5183 Mycobacterium marinum M hypothetical protein YP_001853443.1 6263671 D 216594 CDS YP_001853444.1 183985153 6229478 6264065..6264460 1 NC_010612.1 function unknown; contains a kinase domain. possible role in signal transduction mechanism; putative regulatory protein 6264460 6229478 MMAR_5184 Mycobacterium marinum M putative regulatory protein YP_001853444.1 6264065 D 216594 CDS YP_001853445.1 183985154 6229479 6264453..6265079 1 NC_010612.1 function unknown; contains a sigma factor PP2C-like phosphatase domain. probably part of a signal transduction locus; putative regulatory protein 6265079 6229479 MMAR_5185 Mycobacterium marinum M putative regulatory protein YP_001853445.1 6264453 D 216594 CDS YP_001853446.1 183985155 6229480 6265076..6267304 1 NC_010612.1 sensor-component of a two-component regulator 6267304 6229480 MMAR_5186 Mycobacterium marinum M sensor-component of a two-component regulator YP_001853446.1 6265076 D 216594 CDS YP_001853447.1 183985156 6229481 complement(6267324..6268850) 1 NC_010612.1 function unknown. thought to be regulated by LexA; 13e12 repeat-containing protein 6268850 6229481 MMAR_5187 Mycobacterium marinum M 13e12 repeat-containing protein YP_001853447.1 6267324 R 216594 CDS YP_001853448.1 183985157 6229482 complement(6268894..6269448) 1 NC_010612.1 function unknown; domain homology suggests a role as an intracellular protease/amidase; hypothetical protein 6269448 6229482 MMAR_5188 Mycobacterium marinum M hypothetical protein YP_001853448.1 6268894 R 216594 CDS YP_001853449.1 183985158 6229483 complement(6269640..6270656) 1 NC_010612.1 involved in thiamine biosynthesis [catalytic activity: ATP + thiamine phosphate = ADP + thiamine diphosphate]; thiamine-monophosphate kinase 6270656 6229483 MMAR_5189 Mycobacterium marinum M thiamine-monophosphate kinase YP_001853449.1 6269640 R 216594 CDS YP_001853450.1 183985159 6229485 6270798..6272099 1 NC_010612.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 6272099 selA 6229485 selA Mycobacterium marinum M selenocysteine synthase YP_001853450.1 6270798 D 216594 CDS YP_001853451.1 183985160 6229486 6272087..6273802 1 NC_010612.1 this protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; selenocysteine-specific translation elongation factor, SelB 6273802 selB 6229486 selB Mycobacterium marinum M selenocysteine-specific translation elongation factor, SelB YP_001853451.1 6272087 D 216594 CDS YP_001853452.1 183985161 6229487 complement(6273353..6275248) 1 NC_010612.1 function unknown; extensive overlap with D/S CDS on opposite strand; integral membrane transport protein 6275248 6229487 MMAR_5192 Mycobacterium marinum M integral membrane transport protein YP_001853452.1 6273353 R 216594 CDS YP_001853453.1 183985162 6229488 6275290..6275940 1 NC_010612.1 hypothetical protein 6275940 6229488 MMAR_5193 Mycobacterium marinum M hypothetical protein YP_001853453.1 6275290 D 216594 CDS YP_001853454.1 183985163 6229489 6276023..6276604 1 NC_010612.1 function unknown; potential role in anaerobic electron transport chain. contains formate dehydrogenase/DMSO reductase superfamily domain; formate dehydrogenase subunit alpha, selenocysteine-containing 6276604 6229489 MMAR_5194 Mycobacterium marinum M formate dehydrogenase subunit alpha, selenocysteine-containing YP_001853454.1 6276023 D 216594 CDS YP_001853455.1 183985164 6229490 6276701..6279217 1 NC_010612.1 function unknown; potential role in anaerobic electron transport chain; formate dehydrogenase subunit beta, selenocysteine-containing 6279217 6229490 MMAR_5195 Mycobacterium marinum M formate dehydrogenase subunit beta, selenocysteine-containing YP_001853455.1 6276701 D 216594 CDS YP_001853456.1 183985165 6229491 6279214..6280104 1 NC_010612.1 Fe-S-cluster-containing hydrogenase, HybA 6280104 hybA 6229491 hybA Mycobacterium marinum M Fe-S-cluster-containing hydrogenase, HybA YP_001853456.1 6279214 D 216594 CDS YP_001853457.1 183985166 6229492 6280101..6281072 1 NC_010612.1 NrfD is an integral transmembrane protein with loops in both the periplasm and the cytoplasm. NrfD is thought to participate in the transfer of electrons, from the quinone pool into the terminal components of the Nrf pathway; formate-dependent nitrite reductase, membrane component, NrfD 6281072 nrfD 6229492 nrfD Mycobacterium marinum M formate-dependent nitrite reductase, membrane component, NrfD YP_001853457.1 6280101 D 216594 CDS YP_001853458.1 183985167 6229493 complement(6281083..6281547) 1 NC_010612.1 function unknown, contains GatB/Yqey domain. this domain is found at the C terminus of GatB which transamidates glu-tRNA to Gln-tRNA; hypothetical protein 6281547 6229493 MMAR_5198 Mycobacterium marinum M hypothetical protein YP_001853458.1 6281083 R 216594 CDS YP_001853459.1 183985168 6229494 6281665..6282927 1 NC_010612.1 hypothetical protein 6282927 6229494 MMAR_5199 Mycobacterium marinum M hypothetical protein YP_001853459.1 6281665 D 216594 CDS YP_001853460.1 183985169 6229495 6282948..6283598 1 NC_010612.1 hypothetical protein 6283598 6229495 MMAR_5200 Mycobacterium marinum M hypothetical protein YP_001853460.1 6282948 D 216594 CDS YP_001853461.1 183985170 6229496 6283598..6284737 1 NC_010612.1 hypothetical protein 6284737 6229496 MMAR_5201 Mycobacterium marinum M hypothetical protein YP_001853461.1 6283598 D 216594 CDS YP_001853462.1 183985171 6229497 6284734..6285711 1 NC_010612.1 involved in transcriptional mechanism; regulates methanol dehydrogenase; methanol dehydrogenase transcriptional regulatory protein MoxR2 6285711 moxR2 6229497 moxR2 Mycobacterium marinum M methanol dehydrogenase transcriptional regulatory protein MoxR2 YP_001853462.1 6284734 D 216594 CDS YP_001853463.1 183985172 6229498 6285711..6287033 1 NC_010612.1 function unknown, contains N-term signal peptide; hypothetical protein 6287033 6229498 MMAR_5203 Mycobacterium marinum M hypothetical protein YP_001853463.1 6285711 D 216594 CDS YP_001853464.1 183985173 6229499 complement(6287038..6288030) 1 NC_010612.1 hypothetical protein 6288030 6229499 MMAR_5204 Mycobacterium marinum M hypothetical protein YP_001853464.1 6287038 R 216594 CDS YP_001853465.1 183985174 6229500 6288135..6289040 1 NC_010612.1 function unknown, contains RDD domain RDD family. the molecular function of this region is unknown. however this region may be involved in transport of an as yet unknown set of ligands; hypothetical protein 6289040 6229500 MMAR_5205 Mycobacterium marinum M hypothetical protein YP_001853465.1 6288135 D 216594 CDS YP_001853466.1 183985175 6229501 6289174..6289878 1 NC_010612.1 PadR-like transcriptional regulatory protein 6289878 6229501 MMAR_5206 Mycobacterium marinum M PadR-like transcriptional regulatory protein YP_001853466.1 6289174 D 216594 CDS YP_001853467.1 183985176 6229502 6290038..6292578 1 NC_010612.1 PE-PGRS family protein 6292578 6229502 MMAR_5207 Mycobacterium marinum M PE-PGRS family protein YP_001853467.1 6290038 D 216594 CDS YP_001853468.1 183985177 6229503 complement(6292586..6294112) 1 NC_010612.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 6294112 glpK 6229503 glpK Mycobacterium marinum M glycerol kinase YP_001853468.1 6292586 R 216594 CDS YP_001853469.1 183985178 6229504 6294247..6295728 1 NC_010612.1 hypothetical protein 6295728 6229504 MMAR_5209 Mycobacterium marinum M hypothetical protein YP_001853469.1 6294247 D 216594 CDS YP_001853470.1 183985179 6229505 6295739..6296437 1 NC_010612.1 function unknown; contains thiopurine S- methyltransferase domain. this is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulfhydryl compounds; hypothetical protein 6296437 6229505 MMAR_5210 Mycobacterium marinum M hypothetical protein YP_001853470.1 6295739 D 216594 CDS YP_001853471.1 183985180 6229506 complement(6296453..6297604) 1 NC_010612.1 probable role in the metabolism of proteins containing the rare amino acid selenocysteine; selenocysteine lyase, CsdB 6297604 csdB 6229506 csdB Mycobacterium marinum M selenocysteine lyase, CsdB YP_001853471.1 6296453 R 216594 CDS YP_001853472.1 183985181 6229507 complement(6297601..6298566) 1 NC_010612.1 s-adenosyl-L-methionine- dependentmethyltransferase 6298566 6229507 MMAR_5212 Mycobacterium marinum M s-adenosyl-L-methionine- dependentmethyltransferase YP_001853472.1 6297601 R 216594 CDS YP_001853473.1 183985182 6229508 complement(6298563..6299276) 1 NC_010612.1 function unknown, contains N-terminal nucleophile aminohydrolase superfamily domain; hypothetical protein 6299276 6229508 MMAR_5213 Mycobacterium marinum M hypothetical protein YP_001853473.1 6298563 R 216594 CDS YP_001853474.1 183985183 6229509 complement(6299276..6300577) 1 NC_010612.1 hypothetical protein 6300577 6229509 MMAR_5214 Mycobacterium marinum M hypothetical protein YP_001853474.1 6299276 R 216594 CDS YP_001853475.1 183985184 6229510 complement(6300574..6301863) 1 NC_010612.1 involved in glutathione biosynthesis (at the first step) [catalytic activity: ATP + L-glutamate + L-cysteine = ADP + orthophosphate + gamma-L-glutamyl-L-cysteine]; glutamate--cysteine ligase GshA 6301863 gshA 6229510 gshA Mycobacterium marinum M glutamate--cysteine ligase GshA YP_001853475.1 6300574 R 216594 CDS YP_001853476.1 183985185 6229511 complement(6302011..6302676) 1 NC_010612.1 hypothetical protein 6302676 6229511 MMAR_5216 Mycobacterium marinum M hypothetical protein YP_001853476.1 6302011 R 216594 CDS YP_001853477.1 183985186 6229512 complement(6302706..6304154) 1 NC_010612.1 protects against oxidative stress. converts hydrogen peroxide to water and molecular oxygen; catalase KatE 6304154 katE 6229512 katE Mycobacterium marinum M catalase KatE YP_001853477.1 6302706 R 216594 CDS YP_001853478.1 183985187 6229513 complement(6304329..6304766) 1 NC_010612.1 function unknown, rich in short repeat motifs; hypothetical protein 6304766 6229513 MMAR_5218 Mycobacterium marinum M hypothetical protein YP_001853478.1 6304329 R 216594 CDS YP_001853479.1 183985188 6229514 complement(6304885..6305232) 1 NC_010612.1 function unknown, rich in short repeat motifs; hypothetical protein 6305232 6229514 MMAR_5219 Mycobacterium marinum M hypothetical protein YP_001853479.1 6304885 R 216594 CDS YP_001853480.1 183985189 6229515 complement(6305375..6306511) 1 NC_010612.1 hypothetical protein 6306511 6229515 MMAR_5220 Mycobacterium marinum M hypothetical protein YP_001853480.1 6305375 R 216594 CDS YP_001853481.1 183985190 6229516 complement(6306519..6307577) 1 NC_010612.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 6307577 asd 6229516 asd Mycobacterium marinum M aspartate-semialdehyde dehydrogenase YP_001853481.1 6306519 R 216594 CDS YP_001853482.1 183985191 6229517 complement(6307579..6308844) 1 NC_010612.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 6308844 ask 6229517 ask Mycobacterium marinum M aspartate kinase YP_001853482.1 6307579 R 216594 CDS YP_001853483.1 183985192 6229518 6309196..6312801 1 NC_010612.1 thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane; drug-transport transmembrane ABC transporter ATP-binding protein 6312801 6229518 MMAR_5223 Mycobacterium marinum M drug-transport transmembrane ABC transporter ATP-binding protein YP_001853483.1 6309196 D 216594 CDS YP_001853484.1 183985193 6229519 complement(6312808..6314700) 1 NC_010612.1 hypothetical protein 6314700 6229519 MMAR_5224 Mycobacterium marinum M hypothetical protein YP_001853484.1 6312808 R 216594 CDS YP_001853485.1 183985194 6229520 6315323..6317143 1 NC_010612.1 involved in leucine biosynthesis (at the first step). catalyzes condensation of acetyl-CoA and 2- oxoisovalerate to form 2-isopropylmalate synthase [catalytic activity: 3-carboxy-3-hydroxy-4- methylpentanoate + CoA = acetyl-CoA + 3-methyl-2- oxobutanoate + H(2)O]; 2-isopropylmalate synthase 6317143 leuA 6229520 leuA Mycobacterium marinum M 2-isopropylmalate synthase YP_001853485.1 6315323 D 216594 CDS YP_001853486.1 183985195 6229521 complement(6317140..6317703) 1 NC_010612.1 involved in transcriptional mechanism; DeoR family transcriptional regulator 6317703 6229521 MMAR_5226 Mycobacterium marinum M DeoR family transcriptional regulator YP_001853486.1 6317140 R 216594 CDS YP_001853487.1 183985196 6229522 complement(6317703..6318152) 1 NC_010612.1 function unknown, contains multidrug efflux transporter AcrB transmembrane superfamily domain; hypothetical protein 6318152 6229522 MMAR_5227 Mycobacterium marinum M hypothetical protein YP_001853487.1 6317703 R 216594 CDS YP_001853488.1 183985197 6229523 complement(6318199..6319188) 1 NC_010612.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 6319188 dnaQ 6229523 dnaQ Mycobacterium marinum M DNA polymerase III subunit epsilon YP_001853488.1 6318199 R 216594 CDS YP_001853489.1 183985198 6229524 6319421..6320575 1 NC_010612.1 possible role in cell wall peptidoglycan biogenesis. contains Mur ligase family catalytic domain. possible UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D- alanine ligase, required for the formation of the UDP- MurNAc-linked pentapeptide by addition of the D-Ala-D-Ala subgroup; UDP-N-acetylmuramyl tripeptide synthase 6320575 6229524 MMAR_5229 Mycobacterium marinum M UDP-N-acetylmuramyl tripeptide synthase YP_001853489.1 6319421 D 216594 CDS YP_001853490.1 183985199 6229525 6320568..6321275 1 NC_010612.1 involved in cobalamin biosynthesis. catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic a,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (by similarity); cobyric acid synthase CobQ2 6321275 cobQ2 6229525 cobQ2 Mycobacterium marinum M cobyric acid synthase CobQ2 YP_001853490.1 6320568 D 216594 CDS YP_001853491.1 183985200 6229526 complement(6321291..6321902) 1 NC_010612.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 6321902 recR 6229526 recR Mycobacterium marinum M recombination protein RecR YP_001853491.1 6321291 R 216594 CDS YP_001853492.1 183985201 6229527 complement(6321914..6322357) 1 NC_010612.1 hypothetical protein 6322357 6229527 MMAR_5232 Mycobacterium marinum M hypothetical protein YP_001853492.1 6321914 R 216594 CDS YP_001853493.1 183985202 6229528 6322492..6323217 1 NC_010612.1 hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides; N-acetylmuramoyl-L-alanine amidase 6323217 6229528 MMAR_5233 Mycobacterium marinum M N-acetylmuramoyl-L-alanine amidase YP_001853493.1 6322492 D 216594 CDS YP_001853494.1 183985203 6229529 complement(6323214..6323651) 1 NC_010612.1 function unknown, contains bet v1-like superfamily domain; hypothetical protein 6323651 6229529 MMAR_5234 Mycobacterium marinum M hypothetical protein YP_001853494.1 6323214 R 216594 CDS YP_001853495.1 183985204 6229530 6323698..6325110 1 NC_010612.1 dehydrogenase 6325110 6229530 MMAR_5235 Mycobacterium marinum M dehydrogenase YP_001853495.1 6323698 D 216594 CDS YP_001853496.1 183985205 6229531 6325107..6326426 1 NC_010612.1 cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase catalyses the reaction: S-adenosyl-L- methionine + phospholipid olefinic fatty acid -> S- adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. CFA synthase is closely related to methyltransferases; cyclopropane-fatty-acyl-phospholipid synthase 6326426 6229531 MMAR_5236 Mycobacterium marinum M cyclopropane-fatty-acyl-phospholipid synthase YP_001853496.1 6325107 D 216594 CDS YP_001853497.1 183985206 6229532 6326439..6326681 1 NC_010612.1 hypothetical protein 6326681 6229532 MMAR_5237 Mycobacterium marinum M hypothetical protein YP_001853497.1 6326439 D 216594 CDS YP_001853498.1 183985207 6229533 6326720..6327223 1 NC_010612.1 hypothetical protein 6327223 6229533 MMAR_5238 Mycobacterium marinum M hypothetical protein YP_001853498.1 6326720 D 216594 CDS YP_001853499.1 183985208 6229534 6327220..6327696 1 NC_010612.1 hypothetical protein 6327696 6229534 MMAR_5239 Mycobacterium marinum M hypothetical protein YP_001853499.1 6327220 D 216594 CDS YP_001853500.1 183985209 6229535 complement(6327745..6329646) 1 NC_010612.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 6329646 dnaZX 6229535 dnaZX Mycobacterium marinum M DNA polymerase III subunits gamma and tau YP_001853500.1 6327745 R 216594 CDS YP_001853501.1 183985210 6229536 complement(6329705..6330991) 1 NC_010612.1 transcriptional regulator 6330991 6229536 MMAR_5241 Mycobacterium marinum M transcriptional regulator YP_001853501.1 6329705 R 216594 CDS YP_001853502.1 183985211 6229538 6331436..6332278 1 NC_010612.1 hypothetical protein 6332278 6229538 MMAR_5242 Mycobacterium marinum M hypothetical protein YP_001853502.1 6331436 D 216594 CDS YP_001853503.1 183985212 6229539 complement(6332310..6333056) 1 NC_010612.1 oxidizes fatty acids using specific components [catalytic activity: (3S)-3-hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O]; enoyl-CoA hydratase, EchA3 6333056 echA3_1 6229539 echA3_1 Mycobacterium marinum M enoyl-CoA hydratase, EchA3 YP_001853503.1 6332310 R 216594 CDS YP_001853504.1 183985213 6229540 6333157..6333642 1 NC_010612.1 19 kDa lipoprotein antigen LpqH-like protein 6333642 6229540 MMAR_5244 Mycobacterium marinum M 19 kDa lipoprotein antigen LpqH-like protein YP_001853504.1 6333157 D 216594 CDS YP_001853505.1 183985214 6229541 6333642..6335459 1 NC_010612.1 hypothetical protein 6335459 6229541 MMAR_5245 Mycobacterium marinum M hypothetical protein YP_001853505.1 6333642 D 216594 CDS YP_001853506.1 183985215 6229542 6335456..6336829 1 NC_010612.1 hypothetical protein 6336829 6229542 MMAR_5246 Mycobacterium marinum M hypothetical protein YP_001853506.1 6335456 D 216594 CDS YP_001853507.1 183985216 6229543 complement(6336833..6337276) 1 NC_010612.1 hypothetical protein 6337276 6229543 MMAR_5247 Mycobacterium marinum M hypothetical protein YP_001853507.1 6336833 R 216594 CDS YP_001853508.1 183985217 6229544 6337361..6338692 1 NC_010612.1 hypothetical protein 6338692 6229544 MMAR_5248 Mycobacterium marinum M hypothetical protein YP_001853508.1 6337361 D 216594 CDS YP_001853509.1 183985218 6229545 6338689..6339843 1 NC_010612.1 hypothetical protein 6339843 6229545 MMAR_5249 Mycobacterium marinum M hypothetical protein YP_001853509.1 6338689 D 216594 CDS YP_001853510.1 183985219 6229546 6339884..6340981 1 NC_010612.1 hypothetical protein 6340981 6229546 MMAR_5250 Mycobacterium marinum M hypothetical protein YP_001853510.1 6339884 D 216594 CDS YP_001853511.1 183985220 6229547 6341094..6341789 1 NC_010612.1 hydrolysis of cutin (a polyester that forms the structure of plant cuticle); cutinase 6341789 cut5 6229547 cut5 Mycobacterium marinum M cutinase YP_001853511.1 6341094 D 216594 CDS YP_001853512.1 183985221 6229548 6341830..6342822 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 6342822 6229548 MMAR_5252 Mycobacterium marinum M oxidoreductase YP_001853512.1 6341830 D 216594 CDS YP_001853513.1 183985222 6229549 complement(6343019..6343402) 1 NC_010612.1 hypothetical protein 6343402 6229549 MMAR_5253 Mycobacterium marinum M hypothetical protein YP_001853513.1 6343019 R 216594 CDS YP_001853514.1 183985223 6229550 complement(6343503..6346673) 1 NC_010612.1 involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]. also acts on dATP to form 3',5'-cyclic damp. requires pyruvate. activated by NAD(+) in presence of NAD(P)(+)--arginine ADP- ribosyltransferase; membrane-anchored adenylyl cyclase 6346673 6229550 MMAR_5254 Mycobacterium marinum M membrane-anchored adenylyl cyclase YP_001853514.1 6343503 R 216594 CDS YP_001853515.1 183985224 6229551 6346806..6347117 1 NC_010612.1 hypothetical protein 6347117 6229551 MMAR_5255 Mycobacterium marinum M hypothetical protein YP_001853515.1 6346806 D 216594 CDS YP_001853516.1 183985225 6229552 6347114..6347692 1 NC_010612.1 hypothetical protein 6347692 6229552 MMAR_5256 Mycobacterium marinum M hypothetical protein YP_001853516.1 6347114 D 216594 CDS YP_001853517.1 183985226 6229553 complement(6347712..6350888) 1 NC_010612.1 involved in camp synthesis [catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate]. also acts on dATP to form 3',5'-cyclic damp. requires pyruvate. activated by NAD(+) in presence of NAD(P)(+)--arginine ADP- ribosyltransferase; membrane-anchored adenylyl cyclase 6350888 6229553 MMAR_5257 Mycobacterium marinum M membrane-anchored adenylyl cyclase YP_001853517.1 6347712 R 216594 CDS YP_001853518.1 183985227 6229554 6351135..6351446 1 NC_010612.1 PE family protein 6351446 6229554 MMAR_5258 Mycobacterium marinum M PE family protein YP_001853518.1 6351135 D 216594 CDS YP_001853519.1 183985228 6229555 6351446..6352732 1 NC_010612.1 PPE family protein 6352732 6229555 MMAR_5259 Mycobacterium marinum M PPE family protein YP_001853519.1 6351446 D 216594 CDS YP_001853520.1 183985229 6229556 complement(6352735..6353145) 1 NC_010612.1 hypothetical protein 6353145 6229556 MMAR_5260 Mycobacterium marinum M hypothetical protein YP_001853520.1 6352735 R 216594 CDS YP_001853521.1 183985230 6229557 6353367..6354014 1 NC_010612.1 hypothetical protein 6354014 6229557 MMAR_5261 Mycobacterium marinum M hypothetical protein YP_001853521.1 6353367 D 216594 CDS YP_001853522.1 183985231 6229558 6354082..6354405 1 NC_010612.1 hypothetical protein 6354405 6229558 MMAR_5262 Mycobacterium marinum M hypothetical protein YP_001853522.1 6354082 D 216594 CDS YP_001853523.1 183985232 6229559 6354545..6355204 1 NC_010612.1 hypothetical protein 6355204 6229559 MMAR_5263 Mycobacterium marinum M hypothetical protein YP_001853523.1 6354545 D 216594 CDS YP_001853524.1 183985233 6229560 complement(6355855..6356895) 1 NC_010612.1 hypothetical protein 6356895 6229560 MMAR_5265 Mycobacterium marinum M hypothetical protein YP_001853524.1 6355855 R 216594 CDS YP_001853525.1 183985234 6229561 6356933..6358009 1 NC_010612.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth; ATP-dependent DNA ligase 6358009 ligC 6229561 ligC Mycobacterium marinum M ATP-dependent DNA ligase YP_001853525.1 6356933 D 216594 CDS YP_001853526.1 183985235 6229562 6358108..6358692 1 NC_010612.1 hypothetical protein 6358692 6229562 MMAR_5267 Mycobacterium marinum M hypothetical protein YP_001853526.1 6358108 D 216594 CDS YP_001853527.1 183985236 6229563 complement(6358713..6360041) 1 NC_010612.1 cytochrome P450 are a group of heme-thiolate monooxygenases. they oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; cytochrome P450 164A3 Cyp164A3 6360041 cyp164A3 6229563 cyp164A3 Mycobacterium marinum M cytochrome P450 164A3 Cyp164A3 YP_001853527.1 6358713 R 216594 CDS YP_001853528.1 183985237 6229564 6360049..6361143 1 NC_010612.1 hypothetical protein 6361143 6229564 MMAR_5269 Mycobacterium marinum M hypothetical protein YP_001853528.1 6360049 D 216594 CDS YP_001853529.1 183985238 6229565 complement(6361163..6361645) 1 NC_010612.1 hypothetical protein 6361645 6229565 MMAR_5270 Mycobacterium marinum M hypothetical protein YP_001853529.1 6361163 R 216594 CDS YP_001853530.1 183985239 6229566 complement(6361653..6363017) 1 NC_010612.1 hypothetical protein 6363017 6229566 MMAR_5271 Mycobacterium marinum M hypothetical protein YP_001853530.1 6361653 R 216594 CDS YP_001853531.1 183985240 6229567 complement(6363087..6364166) 1 NC_010612.1 function unknown, involved in cellular metabolism; multi-functional enzyme with acyl-CoA-reductase activity AcrA1 6364166 acrA1_1 6229567 acrA1_1 Mycobacterium marinum M multi-functional enzyme with acyl-CoA-reductase activity AcrA1 YP_001853531.1 6363087 R 216594 CDS YP_001853532.1 183985241 6229568 6364351..6365157 1 NC_010612.1 hypothetical protein 6365157 6229568 MMAR_5273 Mycobacterium marinum M hypothetical protein YP_001853532.1 6364351 D 216594 CDS YP_001853533.1 183985242 6229569 6365202..6365711 1 NC_010612.1 hypothetical protein 6365711 6229569 MMAR_5274 Mycobacterium marinum M hypothetical protein YP_001853533.1 6365202 D 216594 CDS YP_001853534.1 183985243 6229570 complement(6365728..6367530) 1 NC_010612.1 function unknown, but involved in lipid degradation; long-chain-fatty-acid-CoA ligase FadD15 6367530 fadD15_1 6229570 fadD15_1 Mycobacterium marinum M long-chain-fatty-acid-CoA ligase FadD15 YP_001853534.1 6365728 R 216594 CDS YP_001853535.1 183985244 6229571 6367791..6368810 1 NC_010612.1 involved in transcriptional mechanism; AraC/XylS family transcriptional regulator 6368810 6229571 MMAR_5276 Mycobacterium marinum M AraC/XylS family transcriptional regulator YP_001853535.1 6367791 D 216594 CDS YP_001853536.1 183985245 6229572 complement(6368838..6370061) 1 NC_010612.1 PPE family protein 6370061 6229572 MMAR_5277 Mycobacterium marinum M PPE family protein YP_001853536.1 6368838 R 216594 CDS YP_001853537.1 183985246 6229573 complement(6370161..6371519) 1 NC_010612.1 hypothetical protein 6371519 6229573 MMAR_5278 Mycobacterium marinum M hypothetical protein YP_001853537.1 6370161 R 216594 CDS YP_001853538.1 183985247 6229574 complement(6371563..6373062) 1 NC_010612.1 function unknown role in oxidoreduction; monooxygenase-like flavoprotein 6373062 6229574 MMAR_5279 Mycobacterium marinum M monooxygenase-like flavoprotein YP_001853538.1 6371563 R 216594 CDS YP_001853539.1 183985248 6229575 6373368..6374453 1 NC_010612.1 hypothetical protein 6374453 6229575 MMAR_5280 Mycobacterium marinum M hypothetical protein YP_001853539.1 6373368 D 216594 CDS YP_001853540.1 183985249 6229576 6374450..6375223 1 NC_010612.1 short chain dehydrogenase 6375223 6229576 MMAR_5281 Mycobacterium marinum M short chain dehydrogenase YP_001853540.1 6374450 D 216594 CDS YP_001853541.1 183985250 6229577 complement(6375258..6376292) 1 NC_010612.1 involved at the first committed step in the 'phosphorylated' pathway of L-serine biosynthesis [catalytic activity: 3-phosphoglycerate + NAD(+) = 3- phosphohydroxypyruvate + NADH]; D-3-phosphoglycerate dehydrogenase 6376292 serA4 6229577 serA4 Mycobacterium marinum M D-3-phosphoglycerate dehydrogenase YP_001853541.1 6375258 R 216594 CDS YP_001853542.1 183985251 6229578 6376415..6380341 1 NC_010612.1 involved in lipid metabolism; non-ribosomal peptide synthetase 6380341 6229578 MMAR_5283 Mycobacterium marinum M non-ribosomal peptide synthetase YP_001853542.1 6376415 D 216594 CDS YP_001853543.1 183985252 6229579 6380338..6381663 1 NC_010612.1 aminopeptidase with broad substrate specificity to several peptides (could preferentially cleave leucine, arginine and lysine in peptide-bond-containing substrates); aminopeptidase N PepN 6381663 pepN_1 6229579 pepN_1 Mycobacterium marinum M aminopeptidase N PepN YP_001853543.1 6380338 D 216594 CDS YP_001853544.1 183985253 6229580 complement(6381676..6382062) 1 NC_010612.1 hypothetical protein 6382062 6229580 MMAR_5285 Mycobacterium marinum M hypothetical protein YP_001853544.1 6381676 R 216594 CDS YP_001853545.1 183985254 6229581 complement(6382127..6382462) 1 NC_010612.1 PE family protein 6382462 6229581 MMAR_5286 Mycobacterium marinum M PE family protein YP_001853545.1 6382127 R 216594 CDS YP_001853546.1 183985255 6229582 6383008..6383391 1 NC_010612.1 hypothetical protein 6383391 6229582 MMAR_5287 Mycobacterium marinum M hypothetical protein YP_001853546.1 6383008 D 216594 CDS YP_001853547.1 183985256 6229583 complement(6383521..6384270) 1 NC_010612.1 function unknown, supposed involvement in cellular metabolism; short-chain type dehydrogenase/reductase 6384270 6229583 MMAR_5288 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001853547.1 6383521 R 216594 CDS YP_001853548.1 183985257 6229584 complement(6384267..6385505) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hydrolase 6385505 6229584 MMAR_5289 Mycobacterium marinum M hydrolase YP_001853548.1 6384267 R 216594 CDS YP_001853549.1 183985258 6229585 complement(6385520..6386791) 1 NC_010612.1 hypothetical protein 6386791 6229585 MMAR_5290 Mycobacterium marinum M hypothetical protein YP_001853549.1 6385520 R 216594 CDS YP_001853550.1 183985259 6229586 6386920..6387405 1 NC_010612.1 hypothetical protein 6387405 6229586 MMAR_5291 Mycobacterium marinum M hypothetical protein YP_001853550.1 6386920 D 216594 CDS YP_001853551.1 183985260 6229587 6387477..6387860 1 NC_010612.1 hypothetical protein 6387860 6229587 MMAR_5292 Mycobacterium marinum M hypothetical protein YP_001853551.1 6387477 D 216594 CDS YP_001853552.1 183985261 6229588 6387920..6388279 1 NC_010612.1 hypothetical protein 6388279 6229588 MMAR_5293 Mycobacterium marinum M hypothetical protein YP_001853552.1 6387920 D 216594 CDS YP_001853553.1 183985262 6229589 complement(6388395..6395693) 1 NC_010612.1 PE-PGRS family protein 6395693 6229589 MMAR_5294 Mycobacterium marinum M PE-PGRS family protein YP_001853553.1 6388395 R 216594 CDS YP_001853554.1 183985263 6229591 complement(6396270..6396728) 1 NC_010612.1 function unknown, probably involved in deamination of specific substrate; cytidine/deoxycytidylate deaminase 6396728 6229591 MMAR_5295 Mycobacterium marinum M cytidine/deoxycytidylate deaminase YP_001853554.1 6396270 R 216594 CDS YP_001853555.1 183985264 6229592 complement(6396725..6397246) 1 NC_010612.1 hypothetical protein 6397246 6229592 MMAR_5296 Mycobacterium marinum M hypothetical protein YP_001853555.1 6396725 R 216594 CDS YP_001853556.1 183985265 6229593 6397363..6398322 1 NC_010612.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 6398322 tyrA 6229593 tyrA Mycobacterium marinum M prephenate dehydrogenase YP_001853556.1 6397363 D 216594 CDS YP_001853557.1 183985266 6229594 complement(6398285..6398884) 1 NC_010612.1 hypothetical protein 6398884 6229594 MMAR_5298 Mycobacterium marinum M hypothetical protein YP_001853557.1 6398285 R 216594 CDS YP_001853558.1 183985267 6229595 complement(6398889..6399635) 1 NC_010612.1 thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for the translocation of the substrate across the membrane; osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProZ 6399635 proZ 6229595 proZ Mycobacterium marinum M osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProZ YP_001853558.1 6398889 R 216594 CDS YP_001853559.1 183985268 6229596 complement(6399632..6400312) 1 NC_010612.1 thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for the translocation of the substrate across the membrane; osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProW 6400312 proW 6229596 proW Mycobacterium marinum M osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProW YP_001853559.1 6399632 R 216594 CDS YP_001853560.1 183985269 6229597 complement(6400322..6401410) 1 NC_010612.1 thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import). responsible for energy coupling to the transport system; osmoprotectant transport ATP-binding protein ABC transporter ProV 6401410 proV 6229597 proV Mycobacterium marinum M osmoprotectant transport ATP-binding protein ABC transporter ProV YP_001853560.1 6400322 R 216594 CDS YP_001853561.1 183985270 6229598 complement(6401430..6402377) 1 NC_010612.1 thought to be involved in active transport of osmoprotectant (glycine betaine/carnitine/choline/L- proline) across the membrane (import); osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX 6402377 proX 6229598 proX Mycobacterium marinum M osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX YP_001853561.1 6401430 R 216594 CDS YP_001853562.1 183985271 6229599 6402493..6402870 1 NC_010612.1 hypothetical protein 6402870 6229599 MMAR_5303 Mycobacterium marinum M hypothetical protein YP_001853562.1 6402493 D 216594 CDS YP_001853563.1 183985272 6229600 complement(6402932..6403984) 1 NC_010612.1 function unknown, but possibly involvement in lipid degradation; acyl-CoA dehydrogenase FadE36 6403984 fadE36 6229600 fadE36 Mycobacterium marinum M acyl-CoA dehydrogenase FadE36 YP_001853563.1 6402932 R 216594 CDS YP_001853564.1 183985273 6229601 complement(6404070..6404762) 1 NC_010612.1 hypothetical protein 6404762 6229601 MMAR_5305 Mycobacterium marinum M hypothetical protein YP_001853564.1 6404070 R 216594 CDS YP_001853565.1 183985274 6229602 6405085..6408345 1 NC_010612.1 PE-PGRS family protein 6408345 6229602 MMAR_5306 Mycobacterium marinum M PE-PGRS family protein YP_001853565.1 6405085 D 216594 CDS YP_001853566.1 183985275 6229603 6408534..6411728 1 NC_010612.1 PE-PGRS family protein 6411728 6229603 MMAR_5307 Mycobacterium marinum M PE-PGRS family protein YP_001853566.1 6408534 D 216594 CDS YP_001853567.1 183985276 6229604 6411991..6415230 1 NC_010612.1 PE-PGRS family protein 6415230 6229604 MMAR_5308 Mycobacterium marinum M PE-PGRS family protein YP_001853567.1 6411991 D 216594 CDS YP_001853568.1 183985277 6229605 6415312..6416364 1 NC_010612.1 hypothetical protein 6416364 6229605 MMAR_5309 Mycobacterium marinum M hypothetical protein YP_001853568.1 6415312 D 216594 CDS YP_001853569.1 183985278 6229606 6416366..6417130 1 NC_010612.1 function unknown, possibly involved in cellular metabolism; short-chain type dehydrogenase/reductase 6417130 6229606 MMAR_5310 Mycobacterium marinum M short-chain type dehydrogenase/reductase YP_001853569.1 6416366 D 216594 CDS YP_001853570.1 183985279 6229607 6417148..6418455 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE1 6418455 fadE1_1 6229607 fadE1_1 Mycobacterium marinum M acyl-CoA dehydrogenase FadE1 YP_001853570.1 6417148 D 216594 CDS YP_001853571.1 183985280 6229608 6418452..6419054 1 NC_010612.1 hypothetical protein 6419054 6229608 MMAR_5312 Mycobacterium marinum M hypothetical protein YP_001853571.1 6418452 D 216594 CDS YP_001853572.1 183985281 6229609 6419055..6420023 1 NC_010612.1 possibly binds NADP and acts through a one-electron transfer process. quinones are supposed to be the best substrates. may act in the detoxification of xenobiotics [catalytic activity: NADPH + quinone = NADP+ + semiquinone]; quinone oxidoreductase 6420023 6229609 MMAR_5313 Mycobacterium marinum M quinone oxidoreductase YP_001853572.1 6419055 D 216594 CDS YP_001853573.1 183985282 6229610 complement(6420030..6421910) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hydrolase 6421910 6229610 MMAR_5314 Mycobacterium marinum M hydrolase YP_001853573.1 6420030 R 216594 CDS YP_001853574.1 183985283 6229611 6422276..6422575 1 NC_010612.1 19 kDa lipoprotein antigen precursor LpqH 6422575 lpqH 6229611 lpqH Mycobacterium marinum M 19 kDa lipoprotein antigen precursor LpqH YP_001853574.1 6422276 D 216594 CDS YP_001853575.1 183985284 6229612 complement(6422689..6424203) 1 NC_010612.1 sensor part of a two-component regulatory system; two-component sensor kinase TcrY 6424203 tcrY 6229612 tcrY Mycobacterium marinum M two-component sensor kinase TcrY YP_001853575.1 6422689 R 216594 CDS YP_001853576.1 183985285 6229613 complement(6424181..6424888) 1 NC_010612.1 sensor part of a two-component regulatory system; two-component transcriptional regulatory protein TcrX 6424888 tcrX 6229613 tcrX Mycobacterium marinum M two-component transcriptional regulatory protein TcrX YP_001853576.1 6424181 R 216594 CDS YP_001853577.1 183985286 6229614 complement(6425006..6425161) 1 NC_010612.1 hypothetical protein 6425161 6229614 MMAR_5318 Mycobacterium marinum M hypothetical protein YP_001853577.1 6425006 R 216594 CDS YP_001853578.1 183985287 6229615 complement(6425173..6425496) 1 NC_010612.1 hypothetical protein 6425496 6229615 MMAR_5319 Mycobacterium marinum M hypothetical protein YP_001853578.1 6425173 R 216594 CDS YP_001853579.1 183985288 6229616 complement(6425540..6425962) 1 NC_010612.1 hypothetical protein 6425962 6229616 MMAR_5320 Mycobacterium marinum M hypothetical protein YP_001853579.1 6425540 R 216594 CDS YP_001853580.1 183985289 6229617 complement(6426029..6428200) 1 NC_010612.1 PE-PGRS family protein 6428200 6229617 MMAR_5321 Mycobacterium marinum M PE-PGRS family protein YP_001853580.1 6426029 R 216594 CDS YP_001853581.1 183985290 6229618 complement(6428344..6429825) 1 NC_010612.1 PE-PGRS family protein 6429825 6229618 MMAR_5322 Mycobacterium marinum M PE-PGRS family protein YP_001853581.1 6428344 R 216594 CDS YP_001853582.1 183985291 6229619 complement(6430000..6430944) 1 NC_010612.1 function unknown, may play a role in secondary metabolites biosynthesis, transport, and catabolism; O-methyltransferase 6430944 6229619 MMAR_5323 Mycobacterium marinum M O-methyltransferase YP_001853582.1 6430000 R 216594 CDS YP_001853583.1 183985292 6229620 6431055..6431417 1 NC_010612.1 hypothetical protein 6431417 6229620 MMAR_5324 Mycobacterium marinum M hypothetical protein YP_001853583.1 6431055 D 216594 CDS YP_001853584.1 183985293 6229621 6431423..6432451 1 NC_010612.1 hypothetical protein 6432451 6229621 MMAR_5325 Mycobacterium marinum M hypothetical protein YP_001853584.1 6431423 D 216594 CDS YP_001853585.1 183985294 6229624 6432837..6433922 1 NC_010612.1 involved in histidine biosynthetic pathway (at the eighth step) [catalytic activity: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + glutamate]; putative aminotransferase 6433922 hisC2 6229624 hisC2 Mycobacterium marinum M putative aminotransferase YP_001853585.1 6432837 D 216594 CDS YP_001853586.1 183985295 6229625 6433919..6434377 1 NC_010612.1 hypothetical protein 6434377 6229625 MMAR_5327 Mycobacterium marinum M hypothetical protein YP_001853586.1 6433919 D 216594 CDS YP_001853587.1 183985296 6229626 complement(6434403..6434987) 1 NC_010612.1 hypothetical protein 6434987 6229626 MMAR_5328 Mycobacterium marinum M hypothetical protein YP_001853587.1 6434403 R 216594 CDS YP_001853588.1 183985297 6229627 6435011..6435835 1 NC_010612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 6435835 echA21 6229627 echA21 Mycobacterium marinum M enoyl-CoA hydratase YP_001853588.1 6435011 D 216594 CDS YP_001853589.1 183985298 6229628 6435872..6437116 1 NC_010612.1 function unknown, lipolytic enzyme probably involved in cellular metabolism; lipase LipE 6437116 lipE 6229628 lipE Mycobacterium marinum M lipase LipE YP_001853589.1 6435872 D 216594 CDS YP_001853590.1 183985299 6229629 complement(6437142..6439331) 1 NC_010612.1 PPE family protein 6439331 6229629 MMAR_5331 Mycobacterium marinum M PPE family protein YP_001853590.1 6437142 R 216594 CDS YP_001853591.1 183985300 6229631 6439879..6440871 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 6440871 6229631 MMAR_5332 Mycobacterium marinum M oxidoreductase YP_001853591.1 6439879 D 216594 CDS YP_001853592.1 183985301 6229633 complement(6440911..6442107) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; aminotransferase 6442107 6229633 MMAR_5333 Mycobacterium marinum M aminotransferase YP_001853592.1 6440911 R 216594 CDS YP_001853593.1 183985302 6229634 6442238..6444211 1 NC_010612.1 transmembrane protein 6444211 6229634 MMAR_5334 Mycobacterium marinum M transmembrane protein YP_001853593.1 6442238 D 216594 CDS YP_001853594.1 183985303 6229635 6444224..6444757 1 NC_010612.1 hypothetical protein 6444757 6229635 MMAR_5335 Mycobacterium marinum M hypothetical protein YP_001853594.1 6444224 D 216594 CDS YP_001853595.1 183985304 6229636 6444761..6445603 1 NC_010612.1 may form an ATP-driven O-antigen/lipopolysaccharide export apparatus, in association with RfbD. responsible for energy coupling to the transport system; O-antigen/lipopolysaccharide transport ATP- binding protein ABC transporter RfbE 6445603 rfbE 6229636 rfbE Mycobacterium marinum M O-antigen/lipopolysaccharide transport ATP- binding protein ABC transporter RfbE YP_001853595.1 6444761 D 216594 CDS YP_001853596.1 183985305 6229637 6445596..6446525 1 NC_010612.1 possibly involved in rhamnose biosynthesis; L-rhamnosyltransferase 6446525 6229637 MMAR_5337 Mycobacterium marinum M L-rhamnosyltransferase YP_001853596.1 6445596 D 216594 CDS YP_001853597.1 183985306 6229638 6446522..6447352 1 NC_010612.1 may form an ATP-driven O-antigen/lipopolysaccharide export apparatus, in association with RfbE. responsible for the translocation of the substrate across the membrane; O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD 6447352 rfbD 6229638 rfbD Mycobacterium marinum M O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD YP_001853597.1 6446522 D 216594 CDS YP_001853598.1 183985307 6229639 6447485..6449287 1 NC_010612.1 PE-PGRS family protein 6449287 6229639 MMAR_5339 Mycobacterium marinum M PE-PGRS family protein YP_001853598.1 6447485 D 216594 CDS YP_001853599.1 183985308 6229640 complement(6449408..6450769) 1 NC_010612.1 hypothetical protein 6450769 6229640 MMAR_5340 Mycobacterium marinum M hypothetical protein YP_001853599.1 6449408 R 216594 CDS YP_001853600.1 183985309 6229641 6451059..6454103 1 NC_010612.1 PE-PGRS family protein 6454103 6229641 MMAR_5341 Mycobacterium marinum M PE-PGRS family protein YP_001853600.1 6451059 D 216594 CDS YP_001853601.1 183985310 6229642 complement(6454210..6454629) 1 NC_010612.1 hypothetical protein 6454629 6229642 MMAR_5342 Mycobacterium marinum M hypothetical protein YP_001853601.1 6454210 R 216594 CDS YP_001853602.1 183985311 6229643 complement(6454626..6454940) 1 NC_010612.1 involved in transcriptional mechanism; transcriptional regulator 6454940 6229643 MMAR_5343 Mycobacterium marinum M transcriptional regulator YP_001853602.1 6454626 R 216594 CDS YP_001853603.1 183985312 6229644 6455114..6457654 1 NC_010612.1 PE-PGRS family protein 6457654 6229644 MMAR_5344 Mycobacterium marinum M PE-PGRS family protein YP_001853603.1 6455114 D 216594 CDS YP_001853604.1 183985313 6229645 complement(6457684..6458472) 1 NC_010612.1 hypothetical protein 6458472 6229645 MMAR_5345 Mycobacterium marinum M hypothetical protein YP_001853604.1 6457684 R 216594 CDS YP_001853605.1 183985314 6229646 6458741..6459727 1 NC_010612.1 involved in dTDP-L-rhamnose biosynthesis [catalytic activity: dTDP-glucose = DTDP-4-dehydro-6-deoxy-D-glucose + H(2)O]; dTDP-glucose-4,6-dehydratase, RmlB 6459727 rmlB_1 6229646 rmlB_1 Mycobacterium marinum M dTDP-glucose-4,6-dehydratase, RmlB YP_001853605.1 6458741 D 216594 CDS YP_001853606.1 183985315 6229647 complement(6459738..6460964) 1 NC_010612.1 function unknown; domain homology to metallopeptidases; hypothetical protein 6460964 6229647 MMAR_5347 Mycobacterium marinum M hypothetical protein YP_001853606.1 6459738 R 216594 CDS YP_001853607.1 183985316 6229648 6461021..6461251 1 NC_010612.1 hypothetical protein 6461251 6229648 MMAR_5348 Mycobacterium marinum M hypothetical protein YP_001853607.1 6461021 D 216594 CDS YP_001853608.1 183985317 6229649 6461284..6462417 1 NC_010612.1 hypothetical protein 6462417 6229649 MMAR_5349 Mycobacterium marinum M hypothetical protein YP_001853608.1 6461284 D 216594 CDS YP_001853609.1 183985318 6229650 6462612..6463097 1 NC_010612.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 6463097 6229650 MMAR_5350 Mycobacterium marinum M nucleoside diphosphate kinase regulator YP_001853609.1 6462612 D 216594 CDS YP_001853610.1 183985319 6229651 6463157..6463597 1 NC_010612.1 hypothetical protein 6463597 6229651 MMAR_5351 Mycobacterium marinum M hypothetical protein YP_001853610.1 6463157 D 216594 CDS YP_001853611.1 183985320 6229652 6463697..6465088 1 NC_010612.1 function unknown, probably involved in cellular metabolism; oxidoreductase 6465088 6229652 MMAR_5352 Mycobacterium marinum M oxidoreductase YP_001853611.1 6463697 D 216594 CDS YP_001853612.1 183985321 6229653 6465089..6465853 1 NC_010612.1 function unknown, supposed involved in cellular metabolism; short chain dehydrogenase 6465853 6229653 MMAR_5353 Mycobacterium marinum M short chain dehydrogenase YP_001853612.1 6465089 D 216594 CDS YP_001853613.1 183985322 6229654 6465856..6467820 1 NC_010612.1 hypothetical protein 6467820 6229654 MMAR_5354 Mycobacterium marinum M hypothetical protein YP_001853613.1 6465856 D 216594 CDS YP_001853614.1 183985323 6229655 6467820..6471092 1 NC_010612.1 involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]; integral membrane indolylacetylinositol arabinosyltransferase EmbC 6471092 embC 6229655 embC Mycobacterium marinum M integral membrane indolylacetylinositol arabinosyltransferase EmbC YP_001853614.1 6467820 D 216594 CDS YP_001853615.1 183985324 6229656 6471302..6474643 1 NC_010612.1 involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]; integral membrane indolylacetylinositol arabinosyltransferase EmbA 6474643 embA 6229656 embA Mycobacterium marinum M integral membrane indolylacetylinositol arabinosyltransferase EmbA YP_001853615.1 6471302 D 216594 CDS YP_001853616.1 183985325 6229657 6474640..6477867 1 NC_010612.1 involved in the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'-(ethylenediimino)-di-1-butanol). polymerizes arabinose into the arabinan of arabiogalactan [catalytic activity: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside]; integral membrane indolylacetylinositol arabinosyltransferase EmbB 6477867 embB 6229657 embB Mycobacterium marinum M integral membrane indolylacetylinositol arabinosyltransferase EmbB YP_001853616.1 6474640 D 216594 CDS YP_001853617.1 183985326 6229658 6477934..6479079 1 NC_010612.1 hypothetical protein 6479079 6229658 MMAR_5358 Mycobacterium marinum M hypothetical protein YP_001853617.1 6477934 D 216594 CDS YP_001853618.1 183985327 6229659 6479252..6479770 1 NC_010612.1 hypothetical protein 6479770 6229659 MMAR_5359 Mycobacterium marinum M hypothetical protein YP_001853618.1 6479252 D 216594 CDS YP_001853619.1 183985328 6229660 6479913..6480380 1 NC_010612.1 hypothetical protein 6480380 6229660 MMAR_5360 Mycobacterium marinum M hypothetical protein YP_001853619.1 6479913 D 216594 CDS YP_001853620.1 183985329 6229661 6480433..6482229 1 NC_010612.1 function unknown, but involved in lipid degradation; acyl-CoA dehydrogenase FadE35 6482229 fadE35 6229661 fadE35 Mycobacterium marinum M acyl-CoA dehydrogenase FadE35 YP_001853620.1 6480433 D 216594 CDS YP_001853621.1 183985330 6229662 6482363..6488368 1 NC_010612.1 PE-PGRS family protein 6488368 6229662 MMAR_5362 Mycobacterium marinum M PE-PGRS family protein YP_001853621.1 6482363 D 216594 CDS YP_001853622.1 183985331 6229663 complement(6488396..6489976) 1 NC_010612.1 key enzyme in the catabolic pathway of odd-chain fatty acids, isoleucine, threonine, methionine, and valine [catalytic activity: ATP + propionyl-CoA + CO(2) + H(2)O = ADP + orthophosphate + methylmalonyl-CoA.]; propionyl-CoA carboxylase beta chain 4 AccD4 6489976 accD4_1 6229663 accD4_1 Mycobacterium marinum M propionyl-CoA carboxylase beta chain 4 AccD4 YP_001853622.1 6488396 R 216594 CDS YP_001853623.1 183985332 6229664 complement(6489976..6495333) 1 NC_010612.1 the enzyme responsible for the final condensation step in mycolic acid biosynthesis, bringing the short and long (mero) chains together; polyketide synthase Pks13 6495333 pks13 6229664 pks13 Mycobacterium marinum M polyketide synthase Pks13 YP_001853623.1 6489976 R 216594 CDS YP_001853624.1 183985333 6229665 complement(6495356..6497245) 1 NC_010612.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 6497245 fadD32 6229665 fadD32 Mycobacterium marinum M long-chain-fatty-acid--CoA ligase YP_001853624.1 6495356 R 216594 CDS YP_001853625.1 183985334 6229666 complement(6497562..6498575) 1 NC_010612.1 hypothetical protein 6498575 6229666 MMAR_5366 Mycobacterium marinum M hypothetical protein YP_001853625.1 6497562 R 216594 CDS YP_001853626.1 183985335 6229667 complement(6498812..6499717) 1 NC_010612.1 involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity; secreted Mpt51/Mpb51 antigen protein FbpD 6499717 fbpD 6229667 fbpD Mycobacterium marinum M secreted Mpt51/Mpb51 antigen protein FbpD YP_001853626.1 6498812 R 216594 CDS YP_001853627.1 183985336 6229668 complement(6499893..6500906) 1 NC_010612.1 involved in cell wall mycoloylation. proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity; secreted antigen 85-A FbpA 6500906 fbpA 6229668 fbpA Mycobacterium marinum M secreted antigen 85-A FbpA YP_001853627.1 6499893 R 216594 CDS YP_001853628.1 183985337 6229669 complement(6501303..6503222) 1 NC_010612.1 transmembrane protein 6503222 6229669 MMAR_5369 Mycobacterium marinum M transmembrane protein YP_001853628.1 6501303 R 216594 CDS YP_001853629.1 183985338 6229670 complement(6503269..6504177) 1 NC_010612.1 catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase 6504177 6229670 MMAR_5370 Mycobacterium marinum M phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase YP_001853629.1 6503269 R 216594 CDS YP_001853630.1 183985339 6229671 complement(6504174..6504719) 1 NC_010612.1 transmembrane protein 6504719 6229671 MMAR_5371 Mycobacterium marinum M transmembrane protein YP_001853630.1 6504174 R 216594 CDS YP_001853631.1 183985340 6229672 complement(6504712..6506610) 1 NC_010612.1 converts UDP-galactofuranose in cell wall galactan polymerization. has UDP-GalF:beta-D-(1->5) and UDP- GalF:beta-D-(1->6) galactofuranosyltransferase activities; bifunctional UDP-galactofuranosyl transferase GlfT 6506610 glfT 6229672 glfT Mycobacterium marinum M bifunctional UDP-galactofuranosyl transferase GlfT YP_001853631.1 6504712 R 216594 CDS YP_001853632.1 183985341 6229673 complement(6506607..6507815) 1 NC_010612.1 involved in lipopolysaccharide biosynthesis, in the conversion of UDP-galactopyranose into UDP-galactofuranose through a 2-keto intermediate [catalytic activity: UDP-D- galactopyranose = UDP-D-galacto-1,4-furanose]; UDP-galactopyranose mutase Glf 6507815 glf 6229673 glf Mycobacterium marinum M UDP-galactopyranose mutase Glf YP_001853632.1 6506607 R 216594 CDS YP_001853633.1 183985342 6229674 6508140..6509033 1 NC_010612.1 surface-exposed protein required for multiplication and intracellular growth. seems to play a role in virulence; exported repetitive protein Erp 6509033 erp 6229674 erp Mycobacterium marinum M exported repetitive protein Erp YP_001853633.1 6508140 D 216594 CDS YP_001853634.1 183985343 6229675 6509207..6510859 1 NC_010612.1 hypothetical protein 6510859 6229675 MMAR_5375 Mycobacterium marinum M hypothetical protein YP_001853634.1 6509207 D 216594 CDS YP_001853635.1 183985344 6229676 complement(6510875..6511648) 1 NC_010612.1 hypothetical protein 6511648 6229676 MMAR_5376 Mycobacterium marinum M hypothetical protein YP_001853635.1 6510875 R 216594 CDS YP_001853636.1 183985345 6229677 complement(6511699..6512484) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; acyltransferase 6512484 6229677 MMAR_5377 Mycobacterium marinum M acyltransferase YP_001853636.1 6511699 R 216594 CDS YP_001853637.1 183985346 6229678 complement(6512518..6513273) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; acyltransferase 6513273 6229678 MMAR_5378 Mycobacterium marinum M acyltransferase YP_001853637.1 6512518 R 216594 CDS YP_001853638.1 183985347 6229679 complement(6513277..6514056) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; acyltransferase 6514056 6229679 MMAR_5379 Mycobacterium marinum M acyltransferase YP_001853638.1 6513277 R 216594 CDS YP_001853639.1 183985348 6229680 6514129..6514863 1 NC_010612.1 function unknown, probably involved in cellular metabolism [catalytic activity: ATP + substrate = ADP + substrate 3'-phosphate]; phosphotransferase 6514863 6229680 MMAR_5380 Mycobacterium marinum M phosphotransferase YP_001853639.1 6514129 D 216594 CDS YP_001853640.1 183985349 6229681 6514924..6516474 1 NC_010612.1 hypothetical protein 6516474 6229681 MMAR_5381 Mycobacterium marinum M hypothetical protein YP_001853640.1 6514924 D 216594 CDS YP_001853641.1 183985350 6229682 6516474..6516803 1 NC_010612.1 hypothetical protein 6516803 6229682 MMAR_5382 Mycobacterium marinum M hypothetical protein YP_001853641.1 6516474 D 216594 CDS YP_001853642.1 183985351 6229683 complement(6516808..6518385) 1 NC_010612.1 function unknown, probably involved in cellular metabolism; dehydrogenase 6518385 6229683 MMAR_5383 Mycobacterium marinum M dehydrogenase YP_001853642.1 6516808 R 216594 CDS YP_001853643.1 183985352 6229684 complement(6518436..6519083) 1 NC_010612.1 involved in transcriptional mechanism; TetR family transcriptional regulator 6519083 6229684 MMAR_5384 Mycobacterium marinum M TetR family transcriptional regulator YP_001853643.1 6518436 R 216594 CDS YP_001853644.1 183985353 6229685 6519165..6519647 1 NC_010612.1 hypothetical protein 6519647 6229685 MMAR_5385 Mycobacterium marinum M hypothetical protein YP_001853644.1 6519165 D 216594 CDS YP_001853645.1 183985354 6229686 complement(6519644..6520903) 1 NC_010612.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 6520903 serS 6229686 serS Mycobacterium marinum M seryl-tRNA synthetase YP_001853645.1 6519644 R 216594 CDS YP_001853646.1 183985355 6229687 6521015..6522406 1 NC_010612.1 hypothetical protein 6522406 6229687 MMAR_5387 Mycobacterium marinum M hypothetical protein YP_001853646.1 6521015 D 216594 CDS YP_001853647.1 183985356 6229688 6522411..6522761 1 NC_010612.1 hypothetical protein 6522761 6229688 MMAR_5388 Mycobacterium marinum M hypothetical protein YP_001853647.1 6522411 D 216594 CDS YP_001853648.1 183985357 6229689 complement(6523041..6523727) 1 NC_010612.1 thought to be involved in glycolisis and perhaps glycogen metabolism [catalytic activity: 3- phosphoglycerate = 2-phosphoglycerate]; phosphoglycerate mutase 6523727 6229689 MMAR_5389 Mycobacterium marinum M phosphoglycerate mutase YP_001853648.1 6523041 R 216594 CDS YP_001853649.1 183985358 6229690 complement(6523724..6524671) 1 NC_010612.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 6524671 pheA 6229690 pheA Mycobacterium marinum M prephenate dehydratase YP_001853649.1 6523724 R 216594 CDS YP_001853650.1 183985359 6229691 6524755..6525567 1 NC_010612.1 hypothetical protein 6525567 6229691 MMAR_5391 Mycobacterium marinum M hypothetical protein YP_001853650.1 6524755 D 216594 CDS YP_001853651.1 183985360 6229692 6525648..6526877 1 NC_010612.1 supposed involved in transcriptional mechanism; transcriptional regulatory protein 6526877 6229692 MMAR_5392 Mycobacterium marinum M transcriptional regulatory protein YP_001853651.1 6525648 D 216594 CDS YP_001853652.1 183985361 6229693 6527025..6527615 1 NC_010612.1 involved in iron storage; ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited; bacterioferritin BfrB 6527615 bfrB 6229693 bfrB Mycobacterium marinum M bacterioferritin BfrB YP_001853652.1 6527025 D 216594 CDS YP_001853653.1 183985362 6229694 complement(6527612..6528463) 1 NC_010612.1 glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols [catalytic activity: a glycerophosphodiester + H(2)O = an alcohol + SN-glycerol 3- phosphate]; glycerophosphoryl diester phosphodiesterase 6528463 glpQ1 6229694 glpQ1 Mycobacterium marinum M glycerophosphoryl diester phosphodiesterase YP_001853653.1 6527612 R 216594 CDS YP_001853654.1 183985363 6229695 complement(6528463..6529536) 1 NC_010612.1 hypothetical protein 6529536 6229695 MMAR_5395 Mycobacterium marinum M hypothetical protein YP_001853654.1 6528463 R 216594 CDS YP_001853655.1 183985364 6229696 6530003..6530158 1 NC_010612.1 hypothetical protein 6530158 6229696 MMAR_5547 Mycobacterium marinum M hypothetical protein YP_001853655.1 6530003 D 216594 CDS YP_001853656.1 183985365 6229697 6530307..6530930 1 NC_010612.1 destroys radicals which are normally produced within the cells and are toxic to biological systems [catalytic activity: 2 peroxide radical + 2 H(+) = O(2) + H(2)O(2)]; superoxide dismutase [Fe] SodA 6530930 sodA 6229697 sodA Mycobacterium marinum M superoxide dismutase [Fe] SodA YP_001853656.1 6530307 D 216594 CDS YP_001853657.1 183985366 6229698 6531147..6531680 1 NC_010612.1 hypothetical protein 6531680 6229698 MMAR_5397 Mycobacterium marinum M hypothetical protein YP_001853657.1 6531147 D 216594 CDS YP_001853658.1 183985367 6229699 6531934..6532638 1 NC_010612.1 hypothetical protein 6532638 6229699 MMAR_5398 Mycobacterium marinum M hypothetical protein YP_001853658.1 6531934 D 216594 CDS YP_001853659.1 183985368 6229700 6533101..6533499 1 NC_010612.1 hypothetical protein 6533499 6229700 MMAR_5399 Mycobacterium marinum M hypothetical protein YP_001853659.1 6533101 D 216594 CDS YP_001853660.1 183985369 6229701 6533624..6534280 1 NC_010612.1 hypothetical protein 6534280 6229701 MMAR_5400 Mycobacterium marinum M hypothetical protein YP_001853660.1 6533624 D 216594 CDS YP_001853661.1 183985370 6229702 6534287..6534604 1 NC_010612.1 hypothetical protein 6534604 6229702 MMAR_5401 Mycobacterium marinum M hypothetical protein YP_001853661.1 6534287 D 216594 CDS YP_001853662.1 183985371 6229703 6534720..6535190 1 NC_010612.1 histone-like protein Hns 6535190 hns 6229703 hns Mycobacterium marinum M histone-like protein Hns YP_001853662.1 6534720 D 216594 CDS YP_001853663.1 183985372 6229704 6535194..6535691 1 NC_010612.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 6535691 menG 6229704 menG Mycobacterium marinum M ribonuclease activity regulator protein RraA YP_001853663.1 6535194 D 216594 CDS YP_001853664.1 183985373 6229705 complement(6535699..6537168) 1 NC_010612.1 activates the pro-drug ethionamide (eth); induced eth sensitivity when overexpressed in mycobacterium tuberculosis; monooxygenase EthA 6537168 ethA 6229705 ethA Mycobacterium marinum M monooxygenase EthA YP_001853664.1 6535699 R 216594 CDS YP_001853665.1 183985374 6229706 6537241..6537891 1 NC_010612.1 regulates negatively the production of EthA. induced eth resistance when overexpressed in mycobacterium tuberculosis; TetR family transcriptional regulator 6537891 ethR 6229706 ethR Mycobacterium marinum M TetR family transcriptional regulator YP_001853665.1 6537241 D 216594 CDS YP_001853666.1 183985375 6229707 6537923..6539122 1 NC_010612.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 6539122 dinP 6229707 dinP Mycobacterium marinum M DNA polymerase IV YP_001853666.1 6537923 D 216594 CDS YP_001853667.1 183985376 6229708 complement(6539111..6540118) 1 NC_010612.1 hypothetical protein 6540118 6229708 MMAR_5407 Mycobacterium marinum M hypothetical protein YP_001853667.1 6539111 R 216594 CDS YP_001853668.1 183985377 6229709 complement(6540129..6540560) 1 NC_010612.1 hypothetical protein 6540560 6229709 MMAR_5408 Mycobacterium marinum M hypothetical protein YP_001853668.1 6540129 R 216594 CDS YP_001853669.1 183985378 6229710 6540761..6541012 1 NC_010612.1 hypothetical protein 6541012 6229710 MMAR_5548 Mycobacterium marinum M hypothetical protein YP_001853669.1 6540761 D 216594 CDS YP_001853670.1 183985379 6229711 6541224..6541916 1 NC_010612.1 immunogenic protein Mpt64 6541916 mpt64 6229711 mpt64 Mycobacterium marinum M immunogenic protein Mpt64 YP_001853670.1 6541224 D 216594 CDS YP_001853671.1 183985380 6229712 complement(6541930..6542850) 1 NC_010612.1 hypothetical protein 6542850 6229712 MMAR_5410 Mycobacterium marinum M hypothetical protein YP_001853671.1 6541930 R 216594 CDS YP_001853672.1 183985381 6229713 6543114..6543965 1 NC_010612.1 hypothetical protein 6543965 6229713 MMAR_5411 Mycobacterium marinum M hypothetical protein YP_001853672.1 6543114 D 216594 CDS YP_001853673.1 183985382 6229714 complement(6544039..6544149) 1 NC_010612.1 hypothetical protein 6544149 6229714 MMAR_5572 Mycobacterium marinum M hypothetical protein YP_001853673.1 6544039 R 216594 CDS YP_001853674.1 183985383 6229715 complement(6544333..6545799) 1 NC_010612.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 6545799 gltD 6229715 gltD Mycobacterium marinum M glutamate synthase subunit beta YP_001853674.1 6544333 R 216594 CDS YP_001853675.1 183985384 6229716 complement(6545792..6550375) 1 NC_010612.1 probably involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]; ferredoxin-dependent glutamate synthase large subunit GltB 6550375 gltB 6229716 gltB Mycobacterium marinum M ferredoxin-dependent glutamate synthase large subunit GltB YP_001853675.1 6545792 R 216594 CDS YP_001853676.1 183985385 6229717 6551579..6552724 1 NC_010612.1 hypothetical protein 6552724 6229717 MMAR_5414 Mycobacterium marinum M hypothetical protein YP_001853676.1 6551579 D 216594 CDS YP_001853677.1 183985386 6229718 6552956..6554209 1 NC_010612.1 hypothetical protein 6554209 6229718 MMAR_5415 Mycobacterium marinum M hypothetical protein YP_001853677.1 6552956 D 216594 CDS YP_001853678.1 183985387 6229719 6554276..6555361 1 NC_010612.1 hypothetical protein 6555361 6229719 MMAR_5416 Mycobacterium marinum M hypothetical protein YP_001853678.1 6554276 D 216594 CDS YP_001853679.1 183985388 6229720 complement(6555622..6556719) 1 NC_010612.1 PPE family protein 6556719 6229720 MMAR_5417 Mycobacterium marinum M PPE family protein YP_001853679.1 6555622 R 216594 CDS YP_001853680.1 183985389 6229721 6557106..6558458 1 NC_010612.1 hypothetical protein 6558458 6229721 MMAR_5418 Mycobacterium marinum M hypothetical protein YP_001853680.1 6557106 D 216594 CDS YP_001853681.1 183985390 6229722 6558455..6558793 1 NC_010612.1 hypothetical protein 6558793 6229722 MMAR_5419 Mycobacterium marinum M hypothetical protein YP_001853681.1 6558455 D 216594 CDS YP_001853682.1 183985391 6229723 6558824..6559840 1 NC_010612.1 hypothetical protein 6559840 6229723 MMAR_5420 Mycobacterium marinum M hypothetical protein YP_001853682.1 6558824 D 216594 CDS YP_001853683.1 183985392 6229724 6559935..6561170 1 NC_010612.1 hypothetical protein 6561170 6229724 MMAR_5421 Mycobacterium marinum M hypothetical protein YP_001853683.1 6559935 D 216594 CDS YP_001853684.1 183985393 6229725 6561268..6562512 1 NC_010612.1 hypothetical protein 6562512 6229725 MMAR_5422 Mycobacterium marinum M hypothetical protein YP_001853684.1 6561268 D 216594 CDS YP_001853685.1 183985394 6229726 6562512..6563717 1 NC_010612.1 hypothetical protein 6563717 6229726 MMAR_5423 Mycobacterium marinum M hypothetical protein YP_001853685.1 6562512 D 216594 CDS YP_001853686.1 183985395 6229727 6563707..6564747 1 NC_010612.1 hypothetical protein 6564747 6229727 MMAR_5424 Mycobacterium marinum M hypothetical protein YP_001853686.1 6563707 D 216594 CDS YP_001853687.1 183985396 6229728 6564751..6565515 1 NC_010612.1 hypothetical protein 6565515 6229728 MMAR_5425 Mycobacterium marinum M hypothetical protein YP_001853687.1 6564751 D 216594 CDS YP_001853688.1 183985397 6229729 complement(6565895..6566314) 1 NC_010612.1 hypothetical protein 6566314 6229729 MMAR_5426 Mycobacterium marinum M hypothetical protein YP_001853688.1 6565895 R 216594 CDS YP_001853689.1 183985398 6229730 6566333..6567325 1 NC_010612.1 hypothetical protein 6567325 6229730 MMAR_5427 Mycobacterium marinum M hypothetical protein YP_001853689.1 6566333 D 216594 CDS YP_001853690.1 183985399 6229731 6567510..6568499 1 NC_010612.1 hypothetical protein 6568499 6229731 MMAR_5428 Mycobacterium marinum M hypothetical protein YP_001853690.1 6567510 D 216594 CDS YP_001853691.1 183985400 6229732 6568585..6569742 1 NC_010612.1 hypothetical protein 6569742 6229732 MMAR_5429 Mycobacterium marinum M hypothetical protein YP_001853691.1 6568585 D 216594 CDS YP_001853692.1 183985401 6229733 6569815..6571008 1 NC_010612.1 hypothetical protein 6571008 6229733 MMAR_5430 Mycobacterium marinum M hypothetical protein YP_001853692.1 6569815 D 216594 CDS YP_001853693.1 183985402 6229734 6571077..6572282 1 NC_010612.1 hypothetical protein 6572282 6229734 MMAR_5431 Mycobacterium marinum M hypothetical protein YP_001853693.1 6571077 D 216594 CDS YP_001853694.1 183985403 6229735 complement(6572469..6573005) 1 NC_010612.1 hypothetical protein 6573005 6229735 MMAR_5432 Mycobacterium marinum M hypothetical protein YP_001853694.1 6572469 R 216594 CDS YP_001853695.1 183985404 6229736 complement(6573099..6573413) 1 NC_010612.1 hypothetical protein 6573413 6229736 MMAR_5433 Mycobacterium marinum M hypothetical protein YP_001853695.1 6573099 R 216594 CDS YP_001853696.1 183985405 6229737 complement(6573465..6573803) 1 NC_010612.1 hypothetical protein 6573803 6229737 MMAR_5434 Mycobacterium marinum M hypothetical protein YP_001853696.1 6573465 R 216594 CDS YP_001853697.1 183985406 6229738 complement(6573800..6575146) 1 NC_010612.1 hypothetical protein 6575146 6229738 MMAR_5435 Mycobacterium marinum M hypothetical protein YP_001853697.1 6573800 R 216594 CDS YP_001853698.1 183985407 6229739 6575629..6576942 1 NC_010612.1 function unknown; contains SpoJ ATPase domain; hypothetical protein 6576942 6229739 MMAR_5436 Mycobacterium marinum M hypothetical protein YP_001853698.1 6575629 D 216594 CDS YP_001853699.1 183985408 6229740 complement(6577078..6577365) 1 NC_010612.1 hypothetical protein 6577365 6229740 MMAR_5437 Mycobacterium marinum M hypothetical protein YP_001853699.1 6577078 R 216594 CDS YP_001853700.1 183985409 6229741 6577754..6578911 1 NC_010612.1 function unknown; potential regulatory role. contains a FHA domain. the FHA (forkhead-associated) domain is a phosphopeptide binding motif; putative regulatory protein 6578911 6229741 MMAR_5438 Mycobacterium marinum M putative regulatory protein YP_001853700.1 6577754 D 216594 CDS YP_001853701.1 183985410 6229742 6579146..6580402 1 NC_010612.1 hypothetical protein 6580402 6229742 MMAR_5439 Mycobacterium marinum M hypothetical protein YP_001853701.1 6579146 D 216594 CDS YP_001853702.1 183985411 6229743 6580500..6580811 1 NC_010612.1 hypothetical protein 6580811 6229743 MMAR_5440 Mycobacterium marinum M hypothetical protein YP_001853702.1 6580500 D 216594 CDS YP_001853703.1 183985412 6229744 6580813..6581652 1 NC_010612.1 hypothetical protein 6581652 6229744 MMAR_5441 Mycobacterium marinum M hypothetical protein YP_001853703.1 6580813 D 216594 CDS YP_001853704.1 183985413 6229745 6581693..6582250 1 NC_010612.1 hypothetical protein 6582250 6229745 MMAR_5442 Mycobacterium marinum M hypothetical protein YP_001853704.1 6581693 D 216594 CDS YP_001853705.1 183985414 6229746 6582254..6583975 1 NC_010612.1 function unknown; contains predicted ATPase domain; hypothetical protein 6583975 6229746 MMAR_5443 Mycobacterium marinum M hypothetical protein YP_001853705.1 6582254 D 216594 CDS YP_001853706.1 183985415 6229747 6583979..6585424 1 NC_010612.1 hypothetical protein 6585424 6229747 MMAR_5444 Mycobacterium marinum M hypothetical protein YP_001853706.1 6583979 D 216594 CDS YP_001853707.1 183985416 6229748 6585421..6587661 1 NC_010612.1 hypothetical protein 6587661 6229748 MMAR_5445 Mycobacterium marinum M hypothetical protein YP_001853707.1 6585421 D 216594 CDS YP_001853708.1 183985417 6229749 6587711..6589486 1 NC_010612.1 hypothetical protein 6589486 6229749 MMAR_5446 Mycobacterium marinum M hypothetical protein YP_001853708.1 6587711 D 216594 CDS YP_001853709.1 183985418 6229750 6589622..6589918 1 NC_010612.1 PE family protein 6589918 6229750 MMAR_5447 Mycobacterium marinum M PE family protein YP_001853709.1 6589622 D 216594 CDS YP_001853710.1 183985419 6229751 6589963..6591066 1 NC_010612.1 PPE family protein 6591066 6229751 MMAR_5448 Mycobacterium marinum M PPE family protein YP_001853710.1 6589963 D 216594 CDS YP_001853711.1 183985420 6229752 6591158..6591460 1 NC_010612.1 function unknown; a component of a novel secretion apparatus. (10 kDa culture filtrate antigen cfp10); Esat-6 like protein EsxB 6591460 esxB 6229752 esxB Mycobacterium marinum M Esat-6 like protein EsxB YP_001853711.1 6591158 D 216594 CDS YP_001853712.1 183985421 6229753 6591497..6591784 1 NC_010612.1 function unknown; probably a component of a novel secretion mechanism. forms a heterodimer with EsxB; 6 kDa early secretory antigenic target EsxA 6591784 esxA 6229753 esxA Mycobacterium marinum M 6 kDa early secretory antigenic target EsxA YP_001853712.1 6591497 D 216594 CDS YP_001853713.1 183985422 6229754 6591900..6594539 1 NC_010612.1 function unknown; hypothetical protein 6594539 6229754 MMAR_5451 Mycobacterium marinum M hypothetical protein YP_001853713.1 6591900 D 216594 CDS YP_001853714.1 183985423 6229755 6594632..6596071 1 NC_010612.1 hypothetical protein 6596071 6229755 MMAR_5452 Mycobacterium marinum M hypothetical protein YP_001853714.1 6594632 D 216594 CDS YP_001853715.1 183985424 6229756 6596198..6597034 1 NC_010612.1 hypothetical protein 6597034 6229756 MMAR_5453 Mycobacterium marinum M hypothetical protein YP_001853715.1 6596198 D 216594 CDS YP_001853716.1 183985425 6229757 complement(6597020..6597916) 1 NC_010612.1 hypothetical protein 6597916 6229757 MMAR_5454 Mycobacterium marinum M hypothetical protein YP_001853716.1 6597020 R 216594 CDS YP_001853717.1 183985426 6229758 complement(6598333..6600663) 1 NC_010612.1 hypothetical protein 6600663 6229758 MMAR_5455 Mycobacterium marinum M hypothetical protein YP_001853717.1 6598333 R 216594 CDS YP_001853718.1 183985427 6229759 complement(6601072..6601419) 1 NC_010612.1 hypothetical protein 6601419 6229759 MMAR_5456 Mycobacterium marinum M hypothetical protein YP_001853718.1 6601072 R 216594 CDS YP_001853719.1 183985428 6229760 complement(6601456..6602820) 1 NC_010612.1 Required for intracellular persistence; ESX-1 secreted protein, EspB 6602820 espB 6229760 espB Mycobacterium marinum M ESX-1 secreted protein, EspB YP_001853719.1 6601456 R 216594 CDS YP_001853720.1 183985429 6229761 complement(6602919..6604316) 1 NC_010612.1 hypothetical protein 6604316 6229761 MMAR_5458 Mycobacterium marinum M hypothetical protein YP_001853720.1 6602919 R 216594 CDS YP_001853721.1 183985430 6229762 complement(6604313..6605719) 1 NC_010612.1 thought to have proteolytic activity; membrane-anchored serine protease (mycosin), MycP3 6605719 mycP3_1 6229762 mycP3_1 Mycobacterium marinum M membrane-anchored serine protease (mycosin), MycP3 YP_001853721.1 6604313 R 216594 CDS YP_001853722.1 183985431 6229764 complement(6606567..6607442) 1 NC_010612.1 hypothetical protein 6607442 6229764 MMAR_5461 Mycobacterium marinum M hypothetical protein YP_001853722.1 6606567 R 216594 CDS YP_001853723.1 183985432 6229765 complement(6608091..6608621) 1 NC_010612.1 hypothetical protein 6608621 6229765 MMAR_5462 Mycobacterium marinum M hypothetical protein YP_001853723.1 6608091 R 216594 CDS YP_001853724.1 183985433 6229766 complement(6608631..6609239) 1 NC_010612.1 hypothetical protein 6609239 6229766 MMAR_5463 Mycobacterium marinum M hypothetical protein YP_001853724.1 6608631 R 216594 CDS YP_001853725.1 183985434 6229767 complement(6609763..6612183) 1 NC_010612.1 related to a family of actin-ADP-ribosylating toxins from bacillus and clostridia hence may play a role in virulence or protection against predation; ADP-ribosyltransferse 6612183 6229767 MMAR_5464 Mycobacterium marinum M ADP-ribosyltransferse YP_001853725.1 6609763 R 216594 CDS YP_001853726.1 183985435 6229768 complement(6612188..6612478) 1 NC_010612.1 EsaT-6 like protein EsxE 6612478 esxE 6229768 esxE Mycobacterium marinum M EsaT-6 like protein EsxE YP_001853726.1 6612188 R 216594 CDS YP_001853727.1 183985436 6229769 complement(6612471..6612782) 1 NC_010612.1 EsaT-6 like protein EsxF 6612782 esxF 6229769 esxF Mycobacterium marinum M EsaT-6 like protein EsxF YP_001853727.1 6612471 R 216594 CDS YP_001853728.1 183985437 6229770 complement(6612893..6613381) 1 NC_010612.1 lipoprotein LppJ 6613381 lppJ 6229770 lppJ Mycobacterium marinum M lipoprotein LppJ YP_001853728.1 6612893 R 216594 CDS YP_001853729.1 183985438 6229771 complement(6613461..6615548) 1 NC_010612.1 hypothetical protein 6615548 6229771 MMAR_5468 Mycobacterium marinum M hypothetical protein YP_001853729.1 6613461 R 216594 CDS YP_001853730.1 183985439 6229772 complement(6615844..6616158) 1 NC_010612.1 hypothetical protein 6616158 6229772 MMAR_5469 Mycobacterium marinum M hypothetical protein YP_001853730.1 6615844 R 216594 CDS YP_001853731.1 183985440 6229773 complement(6616290..6616799) 1 NC_010612.1 hypothetical protein 6616799 6229773 MMAR_5470 Mycobacterium marinum M hypothetical protein YP_001853731.1 6616290 R 216594 CDS YP_001853732.1 183985441 6229774 complement(6616824..6618269) 1 NC_010612.1 involved in transcription mechanism [catalytic activity: N ATP + (nucleotide)(M) = N diphosphate + (nucleotide)(M+N)]; poly(a) polymerase PcnA 6618269 pcnA 6229774 pcnA Mycobacterium marinum M poly(a) polymerase PcnA YP_001853732.1 6616824 R 216594 CDS YP_001853733.1 183985442 6229775 6618435..6619181 1 NC_010612.1 hypothetical protein 6619181 6229775 MMAR_5472 Mycobacterium marinum M hypothetical protein YP_001853733.1 6618435 D 216594 CDS YP_001853734.1 183985443 6229776 6619178..6621559 1 NC_010612.1 hypothetical protein 6621559 6229776 MMAR_5473 Mycobacterium marinum M hypothetical protein YP_001853734.1 6619178 D 216594 CDS YP_001853735.1 183985444 6229777 6621676..6625218 1 NC_010612.1 transmembrane protein 6625218 6229777 MMAR_5474 Mycobacterium marinum M transmembrane protein YP_001853735.1 6621676 D 216594 CDS YP_001853736.1 183985445 6229778 6625280..6625867 1 NC_010612.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase; RNA polymerase sigma factor SigM 6625867 sigM 6229778 sigM Mycobacterium marinum M RNA polymerase sigma factor SigM YP_001853736.1 6625280 D 216594 CDS YP_001853737.1 183985446 6229779 6625943..6626692 1 NC_010612.1 hypothetical protein 6626692 6229779 MMAR_5476 Mycobacterium marinum M hypothetical protein YP_001853737.1 6625943 D 216594 CDS YP_001853738.1 183985447 6229780 6626782..6627780 1 NC_010612.1 enzyme that catalyse the reduction of disulphides by pyridine nucleotides through an enzyme disulphide and a flavin. seems regulated by SigH. [catalytic activity: NADPH + oxidized thioredoxin = NADP(+) + reduced thioredoxin]; thioredoxin reductase TrxB2 6627780 trxB2 6229780 trxB2 Mycobacterium marinum M thioredoxin reductase TrxB2 YP_001853738.1 6626782 D 216594 CDS YP_001853739.1 183985448 6229781 6627777..6628130 1 NC_010612.1 thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol, to a disulfide, & catalyzes dithiol-disulfide exchange reactions. forms together with thioredoxin reductase and NADPH a redox active system which donates electrons to a wide variety of different metabolic process (by similarity). seems regulated by SigH; thioredoxin TrxC 6628130 trxC 6229781 trxC Mycobacterium marinum M thioredoxin TrxC YP_001853739.1 6627777 D 216594 CDS YP_001853740.1 183985449 6229782 6628262..6629482 1 NC_010612.1 function unknown, probably involved in cellular metabolism; hydrolase 6629482 6229782 MMAR_5479 Mycobacterium marinum M hydrolase YP_001853740.1 6628262 D 216594 CDS YP_001853741.1 183985450 6229783 complement(6629521..6630252) 1 NC_010612.1 hypothetical protein 6630252 6229783 MMAR_5480 Mycobacterium marinum M hypothetical protein YP_001853741.1 6629521 R 216594 CDS YP_001853742.1 183985451 6229784 complement(6630723..6631706) 1 NC_010612.1 involved in chromosome partition. localize to both poles of the predivisional cell following completion of DNA replication. binds to the DNA origin of replication (by similarity); chromosome partitioning protein ParB 6631706 parB 6229784 parB Mycobacterium marinum M chromosome partitioning protein ParB YP_001853742.1 6630723 R 216594 CDS YP_001853743.1 183985452 6229785 complement(6631703..6632836) 1 NC_010612.1 involved in chromosome partition. localize to both poles of the predivisional cell following completion of DNA replication (by similarity); chromosome partitioning protein ParA 6632836 parA 6229785 parA Mycobacterium marinum M chromosome partitioning protein ParA YP_001853743.1 6631703 R 216594 CDS YP_001853744.1 183985453 6229786 complement(6632833..6633519) 1 NC_010612.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 6633519 gidB 6229786 gidB Mycobacterium marinum M 16S rRNA methyltransferase GidB YP_001853744.1 6632833 R 216594 CDS YP_001853745.1 183985454 6229787 complement(6633672..6634220) 1 NC_010612.1 function unknown, domain identity suggests it is a JAG RNA-binding protein; hypothetical protein 6634220 6229787 MMAR_5484 Mycobacterium marinum M hypothetical protein YP_001853745.1 6633672 R 216594 CDS YP_001853746.1 183985455 6229788 complement(6634333..6635448) 1 NC_010612.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 6635448 6229788 MMAR_5485 Mycobacterium marinum M putative inner membrane protein translocase component YidC YP_001853746.1 6634333 R 216594 CDS YP_001853747.1 183985456 6229789 complement(6635432..6635740) 1 NC_010612.1 hypothetical protein 6635740 6229789 MMAR_5578 Mycobacterium marinum M hypothetical protein YP_001853747.1 6635432 R 216594 CDS YP_001853748.1 183985457 6229790 complement(6635767..6636129) 1 NC_010612.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 6636129 rnpA 6229790 rnpA Mycobacterium marinum M ribonuclease P YP_001853748.1 6635767 R 216594 CDS YP_001853749.1 183985458 6229791 complement(6636153..6636296) 1 NC_010612.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 6636296 rpmH 6229791 rpmH Mycobacterium marinum M 50S ribosomal protein L34 YP_001853749.1 6636153 R 216594 CDS