-- dump date   	20120504_153017
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
710685000001	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685000002	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685000003	active site
710685000004	ATP binding site [chemical binding]; other site
710685000005	substrate binding site [chemical binding]; other site
710685000006	activation loop (A-loop); other site
710685000007	FlgD Ig-like domain; Region: FlgD_ig; cl15790
710685000008	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685000009	mce related protein; Region: MCE; pfam02470
710685000010	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685000011	mce related protein; Region: MCE; pfam02470
710685000012	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685000013	mce related protein; Region: MCE; pfam02470
710685000014	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685000015	mce related protein; Region: MCE; pfam02470
710685000016	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685000017	mce related protein; Region: MCE; pfam02470
710685000018	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
710685000019	mce related protein; Region: MCE; pfam02470
710685000020	Permease; Region: Permease; cl00510
710685000021	Permease; Region: Permease; cl00510
710685000022	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
710685000023	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
710685000024	active site
710685000025	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
710685000026	active site
710685000027	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685000028	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
710685000029	nickel binding site [ion binding]; other site
710685000030	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
710685000031	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
710685000032	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
710685000033	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
710685000034	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
710685000035	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
710685000036	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
710685000037	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
710685000038	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
710685000039	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
710685000040	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685000041	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685000042	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685000043	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685000044	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000045	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
710685000046	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
710685000047	phosphoenolpyruvate synthase; Validated; Region: PRK06464
710685000048	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
710685000049	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
710685000050	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
710685000051	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
710685000052	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000053	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685000054	4Fe-4S binding domain; Region: Fer4; cl02805
710685000055	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
710685000056	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
710685000057	dimer interface [polypeptide binding]; other site
710685000058	PYR/PP interface [polypeptide binding]; other site
710685000059	TPP binding site [chemical binding]; other site
710685000060	substrate binding site [chemical binding]; other site
710685000061	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
710685000062	Domain of unknown function; Region: EKR; cl11037
710685000063	4Fe-4S binding domain; Region: Fer4; cl02805
710685000064	4Fe-4S binding domain; Region: Fer4; cl02805
710685000065	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
710685000066	TPP-binding site [chemical binding]; other site
710685000067	dimer interface [polypeptide binding]; other site
710685000068	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
710685000069	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
710685000070	putative active site [active]
710685000071	putative FMN binding site [chemical binding]; other site
710685000072	putative substrate binding site [chemical binding]; other site
710685000073	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685000074	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685000075	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
710685000076	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685000077	Ligand Binding Site [chemical binding]; other site
710685000078	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685000079	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
710685000080	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685000081	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
710685000082	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
710685000083	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
710685000084	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
710685000085	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
710685000086	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
710685000087	putative substrate binding site [chemical binding]; other site
710685000088	putative ATP binding site [chemical binding]; other site
710685000089	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
710685000090	4Fe-4S binding domain; Region: Fer4; cl02805
710685000091	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
710685000092	FMN binding site [chemical binding]; other site
710685000093	dimer interface [polypeptide binding]; other site
710685000094	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
710685000095	Helix-turn-helix domains; Region: HTH; cl00088
710685000096	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000097	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
710685000098	NAD(P) binding site [chemical binding]; other site
710685000099	active site
710685000100	Transcriptional regulator [Transcription]; Region: IclR; COG1414
710685000101	Helix-turn-helix domains; Region: HTH; cl00088
710685000102	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685000103	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685000104	classical (c) SDRs; Region: SDR_c; cd05233
710685000105	NAD(P) binding site [chemical binding]; other site
710685000106	active site
710685000107	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
710685000108	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685000109	Helix-turn-helix domains; Region: HTH; cl00088
710685000110	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685000111	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685000112	short chain dehydrogenase; Provisional; Region: PRK12827
710685000113	classical (c) SDRs; Region: SDR_c; cd05233
710685000114	NAD(P) binding site [chemical binding]; other site
710685000115	active site
710685000116	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685000117	classical (c) SDRs; Region: SDR_c; cd05233
710685000118	NAD(P) binding site [chemical binding]; other site
710685000119	active site
710685000120	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685000121	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685000122	Helix-turn-helix domains; Region: HTH; cl00088
710685000123	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
710685000124	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000125	NAD(P) binding site [chemical binding]; other site
710685000126	active site
710685000127	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685000128	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000129	NAD(P) binding site [chemical binding]; other site
710685000130	active site
710685000131	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
710685000132	classical (c) SDRs; Region: SDR_c; cd05233
710685000133	NAD(P) binding site [chemical binding]; other site
710685000134	active site
710685000135	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685000136	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
710685000137	Transcriptional regulators [Transcription]; Region: FadR; COG2186
710685000138	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685000139	DNA-binding site [nucleotide binding]; DNA binding site
710685000140	FCD domain; Region: FCD; cl11656
710685000141	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
710685000142	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000143	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000144	NAD(P) binding site [chemical binding]; other site
710685000145	active site
710685000146	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
710685000147	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
710685000148	FAD binding pocket [chemical binding]; other site
710685000149	FAD binding motif [chemical binding]; other site
710685000150	phosphate binding motif [ion binding]; other site
710685000151	beta-alpha-beta structure motif; other site
710685000152	NAD binding pocket [chemical binding]; other site
710685000153	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685000154	catalytic loop [active]
710685000155	iron binding site [ion binding]; other site
710685000156	Fatty acid desaturase; Region: FA_desaturase; pfam00487
710685000157	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
710685000158	putative di-iron ligands [ion binding]; other site
710685000159	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
710685000160	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
710685000161	ABC-2 type transporter; Region: ABC2_membrane; cl11417
710685000162	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
710685000163	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
710685000164	Walker A/P-loop; other site
710685000165	ATP binding site [chemical binding]; other site
710685000166	Q-loop/lid; other site
710685000167	ABC transporter signature motif; other site
710685000168	Walker B; other site
710685000169	D-loop; other site
710685000170	H-loop/switch region; other site
710685000171	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
710685000172	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
710685000173	active site
710685000174	Acyl transferase domain; Region: Acyl_transf_1; cl08282
710685000175	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
710685000176	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
710685000177	putative NADP binding site [chemical binding]; other site
710685000178	active site
710685000179	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685000180	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
710685000181	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000182	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
710685000183	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685000184	classical (c) SDRs; Region: SDR_c; cd05233
710685000185	NAD(P) binding site [chemical binding]; other site
710685000186	active site
710685000187	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
710685000188	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
710685000189	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
710685000190	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685000191	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
710685000192	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
710685000193	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
710685000194	FAD binding pocket [chemical binding]; other site
710685000195	FAD binding motif [chemical binding]; other site
710685000196	catalytic residues [active]
710685000197	NAD binding pocket [chemical binding]; other site
710685000198	phosphate binding motif [ion binding]; other site
710685000199	beta-alpha-beta structure motif; other site
710685000200	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
710685000201	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
710685000202	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
710685000203	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
710685000204	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
710685000205	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
710685000206	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
710685000207	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
710685000208	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
710685000209	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685000210	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
710685000211	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685000212	Walker A motif; other site
710685000213	ATP binding site [chemical binding]; other site
710685000214	Walker B motif; other site
710685000215	arginine finger; other site
710685000216	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
710685000217	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685000218	S-adenosylmethionine binding site [chemical binding]; other site
710685000219	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
710685000220	classical (c) SDRs; Region: SDR_c; cd05233
710685000221	NAD(P) binding site [chemical binding]; other site
710685000222	active site
710685000223	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685000224	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685000225	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
710685000226	NAD(P) binding site [chemical binding]; other site
710685000227	catalytic residues [active]
710685000228	lipid-transfer protein; Provisional; Region: PRK07855
710685000229	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685000230	active site
710685000231	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
710685000232	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685000233	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685000234	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685000235	[2Fe-2S] cluster binding site [ion binding]; other site
710685000236	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685000237	hydrophobic ligand binding site; other site
710685000238	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000239	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
710685000240	NAD(P) binding site [chemical binding]; other site
710685000241	active site
710685000242	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685000243	enoyl-CoA hydratase; Provisional; Region: PRK12478
710685000244	substrate binding site [chemical binding]; other site
710685000245	oxyanion hole (OAH) forming residues; other site
710685000246	trimer interface [polypeptide binding]; other site
710685000247	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
710685000248	putative hydrophobic ligand binding site [chemical binding]; other site
710685000249	protein interface [polypeptide binding]; other site
710685000250	gate; other site
710685000251	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685000252	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
710685000253	active site
710685000254	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685000255	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685000256	active site
710685000257	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685000258	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685000259	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685000260	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685000261	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685000262	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685000263	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
710685000264	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685000265	active site
710685000266	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685000267	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685000268	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685000269	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685000270	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685000271	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685000272	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685000273	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685000274	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
710685000275	active site
710685000276	metal binding site [ion binding]; metal-binding site
710685000277	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685000278	enoyl-CoA hydratase; Provisional; Region: PRK06494
710685000279	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685000280	substrate binding site [chemical binding]; other site
710685000281	oxyanion hole (OAH) forming residues; other site
710685000282	trimer interface [polypeptide binding]; other site
710685000283	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
710685000284	AMP-binding enzyme; Region: AMP-binding; cl15778
710685000285	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
710685000286	Strictosidine synthase; Region: Str_synth; pfam03088
710685000287	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
710685000288	classical (c) SDRs; Region: SDR_c; cd05233
710685000289	NAD(P) binding site [chemical binding]; other site
710685000290	active site
710685000291	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
710685000292	active site
710685000293	catalytic site [active]
710685000294	short chain dehydrogenase; Provisional; Region: PRK12939
710685000295	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000296	NAD(P) binding site [chemical binding]; other site
710685000297	active site
710685000298	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685000299	Protein of unknown function (DUF3237); Region: DUF3237; cl07905
710685000300	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
710685000301	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
710685000302	active site
710685000303	metal binding site [ion binding]; metal-binding site
710685000304	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685000305	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685000306	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
710685000307	active site
710685000308	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685000309	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685000310	active site
710685000311	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
710685000312	active site
710685000313	catalytic site [active]
710685000314	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685000315	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
710685000316	tetramerization interface [polypeptide binding]; other site
710685000317	NAD(P) binding site [chemical binding]; other site
710685000318	catalytic residues [active]
710685000319	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685000320	active site 2 [active]
710685000321	active site 1 [active]
710685000322	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685000323	classical (c) SDRs; Region: SDR_c; cd05233
710685000324	NAD(P) binding site [chemical binding]; other site
710685000325	active site
710685000326	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
710685000327	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
710685000328	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
710685000329	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685000330	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685000331	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
710685000332	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685000333	active site
710685000334	Phosphotransferase enzyme family; Region: APH; pfam01636
710685000335	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685000336	active site
710685000337	ATP binding site [chemical binding]; other site
710685000338	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685000339	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
710685000340	dimerization interface [polypeptide binding]; other site
710685000341	cyclase homology domain; Region: CHD; cd07302
710685000342	nucleotidyl binding site; other site
710685000343	metal binding site [ion binding]; metal-binding site
710685000344	dimer interface [polypeptide binding]; other site
710685000345	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685000346	classical (c) SDRs; Region: SDR_c; cd05233
710685000347	NAD(P) binding site [chemical binding]; other site
710685000348	active site
710685000349	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000350	NAD(P) binding site [chemical binding]; other site
710685000351	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
710685000352	active site
710685000353	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685000354	enoyl-CoA hydratase; Provisional; Region: PRK06688
710685000355	substrate binding site [chemical binding]; other site
710685000356	oxyanion hole (OAH) forming residues; other site
710685000357	trimer interface [polypeptide binding]; other site
710685000358	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685000359	enoyl-CoA hydratase; Provisional; Region: PRK08290
710685000360	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685000361	substrate binding site [chemical binding]; other site
710685000362	oxyanion hole (OAH) forming residues; other site
710685000363	trimer interface [polypeptide binding]; other site
710685000364	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685000365	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
710685000366	active site
710685000367	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685000368	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685000369	substrate binding site [chemical binding]; other site
710685000370	oxyanion hole (OAH) forming residues; other site
710685000371	trimer interface [polypeptide binding]; other site
710685000372	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685000373	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685000374	substrate binding site [chemical binding]; other site
710685000375	oxyanion hole (OAH) forming residues; other site
710685000376	trimer interface [polypeptide binding]; other site
710685000377	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
710685000378	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
710685000379	FMN binding site [chemical binding]; other site
710685000380	substrate binding site [chemical binding]; other site
710685000381	putative catalytic residue [active]
710685000382	enoyl-CoA hydratase; Provisional; Region: PRK06688
710685000383	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685000384	substrate binding site [chemical binding]; other site
710685000385	oxyanion hole (OAH) forming residues; other site
710685000386	trimer interface [polypeptide binding]; other site
710685000387	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
710685000388	E3 interaction surface; other site
710685000389	lipoyl attachment site [posttranslational modification]; other site
710685000390	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
710685000391	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
710685000392	tetramer interface [polypeptide binding]; other site
710685000393	TPP-binding site [chemical binding]; other site
710685000394	heterodimer interface [polypeptide binding]; other site
710685000395	phosphorylation loop region [posttranslational modification]
710685000396	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
710685000397	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
710685000398	alpha subunit interface [polypeptide binding]; other site
710685000399	TPP binding site [chemical binding]; other site
710685000400	heterodimer interface [polypeptide binding]; other site
710685000401	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
710685000402	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685000403	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685000404	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685000405	thiolase; Provisional; Region: PRK06158
710685000406	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685000407	active site
710685000408	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685000409	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
710685000410	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685000411	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
710685000412	dimer interaction site [polypeptide binding]; other site
710685000413	substrate-binding tunnel; other site
710685000414	active site
710685000415	catalytic site [active]
710685000416	substrate binding site [chemical binding]; other site
710685000417	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
710685000418	Helix-turn-helix domains; Region: HTH; cl00088
710685000419	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685000420	classical (c) SDRs; Region: SDR_c; cd05233
710685000421	NAD(P) binding site [chemical binding]; other site
710685000422	active site
710685000423	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
710685000424	AMP-binding enzyme; Region: AMP-binding; cl15778
710685000425	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685000426	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
710685000427	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
710685000428	active site
710685000429	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685000430	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000431	NAD(P) binding site [chemical binding]; other site
710685000432	active site
710685000433	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685000434	Helix-turn-helix domains; Region: HTH; cl00088
710685000435	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
710685000436	classical (c) SDRs; Region: SDR_c; cd05233
710685000437	NAD(P) binding site [chemical binding]; other site
710685000438	active site
710685000439	Domain of unknown function (DUF427); Region: DUF427; cl00998
710685000440	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
710685000441	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
710685000442	active site
710685000443	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
710685000444	catalytic triad [active]
710685000445	dimer interface [polypeptide binding]; other site
710685000446	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685000447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000448	NAD(P) binding site [chemical binding]; other site
710685000449	active site
710685000450	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000451	NAD(P) binding site [chemical binding]; other site
710685000452	active site
710685000453	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685000454	classical (c) SDRs; Region: SDR_c; cd05233
710685000455	NAD(P) binding site [chemical binding]; other site
710685000456	active site
710685000457	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685000458	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
710685000459	DNA-binding interface [nucleotide binding]; DNA binding site
710685000460	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685000461	Ligand Binding Site [chemical binding]; other site
710685000462	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
710685000463	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
710685000464	synthetase active site [active]
710685000465	NTP binding site [chemical binding]; other site
710685000466	metal binding site [ion binding]; metal-binding site
710685000467	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
710685000468	heme-binding site [chemical binding]; other site
710685000469	Helix-turn-helix domains; Region: HTH; cl00088
710685000470	Protein of unknown function, DUF488; Region: DUF488; cl01246
710685000471	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
710685000472	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
710685000473	THF binding site; other site
710685000474	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
710685000475	substrate binding site [chemical binding]; other site
710685000476	THF binding site; other site
710685000477	zinc-binding site [ion binding]; other site
710685000478	aconitate hydratase; Validated; Region: PRK09277
710685000479	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
710685000480	substrate binding site [chemical binding]; other site
710685000481	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
710685000482	ligand binding site [chemical binding]; other site
710685000483	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
710685000484	substrate binding site [chemical binding]; other site
710685000485	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685000486	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685000487	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
710685000488	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
710685000489	4Fe-4S binding domain; Region: Fer4; cl02805
710685000490	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
710685000491	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000492	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
710685000493	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
710685000494	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
710685000495	putative Iron-sulfur protein interface [polypeptide binding]; other site
710685000496	proximal heme binding site [chemical binding]; other site
710685000497	distal heme binding site [chemical binding]; other site
710685000498	putative dimer interface [polypeptide binding]; other site
710685000499	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
710685000500	OsmC-like protein; Region: OsmC; cl00767
710685000501	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
710685000502	GTP cyclohydrolase I; Provisional; Region: PLN03044
710685000503	active site
710685000504	DoxX; Region: DoxX; cl00976
710685000505	Helix-turn-helix domains; Region: HTH; cl00088
710685000506	Predicted transcriptional regulator [Transcription]; Region: COG2345
710685000507	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
710685000508	putative active site [active]
710685000509	transaldolase; Provisional; Region: PRK03903
710685000510	catalytic residue [active]
710685000511	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
710685000512	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685000513	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
710685000514	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
710685000515	D-pathway; other site
710685000516	Putative ubiquinol binding site [chemical binding]; other site
710685000517	Low-spin heme (heme b) binding site [chemical binding]; other site
710685000518	Putative water exit pathway; other site
710685000519	Binuclear center (heme o3/CuB) [ion binding]; other site
710685000520	K-pathway; other site
710685000521	Putative proton exit pathway; other site
710685000522	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
710685000523	Ferredoxin [Energy production and conversion]; Region: COG1146
710685000524	4Fe-4S binding domain; Region: Fer4; cl02805
710685000525	Predicted transcriptional regulator [Transcription]; Region: COG2345
710685000526	Helix-turn-helix domains; Region: HTH; cl00088
710685000527	Cupin domain; Region: Cupin_2; cl09118
710685000528	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
710685000529	Helix-turn-helix domains; Region: HTH; cl00088
710685000530	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685000531	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685000532	DNA binding residues [nucleotide binding]
710685000533	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
710685000534	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
710685000535	tetramer interface [polypeptide binding]; other site
710685000536	heme binding pocket [chemical binding]; other site
710685000537	NADPH binding site [chemical binding]; other site
710685000538	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
710685000539	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
710685000540	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
710685000541	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000542	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
710685000543	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
710685000544	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
710685000545	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
710685000546	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
710685000547	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
710685000548	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
710685000549	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
710685000550	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
710685000551	active site
710685000552	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
710685000553	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685000554	active site
710685000555	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
710685000556	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685000557	CoenzymeA binding site [chemical binding]; other site
710685000558	subunit interaction site [polypeptide binding]; other site
710685000559	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
710685000560	metal binding site [ion binding]; metal-binding site
710685000561	active site
710685000562	I-site; other site
710685000563	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
710685000564	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
710685000565	SmpB-tmRNA interface; other site
710685000566	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
710685000567	FtsX-like permease family; Region: FtsX; cl15850
710685000568	FtsX-like permease family; Region: FtsX; cl15850
710685000569	Type II (General) Secretory Pathway (IISP) Family protein; Region: 3a0501s02; TIGR00960
710685000570	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685000571	Walker A/P-loop; other site
710685000572	ATP binding site [chemical binding]; other site
710685000573	Q-loop/lid; other site
710685000574	ABC transporter signature motif; other site
710685000575	Walker B; other site
710685000576	D-loop; other site
710685000577	H-loop/switch region; other site
710685000578	Mechanosensitive ion channel; Region: MS_channel; pfam00924
710685000579	peptide chain release factor 2; Validated; Region: prfB; PRK00578
710685000580	RF-1 domain; Region: RF-1; cl02875
710685000581	RF-1 domain; Region: RF-1; cl02875
710685000582	ferredoxin-NADP+ reductase; Region: PLN02852
710685000583	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
710685000584	active site
710685000585	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685000586	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685000587	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
710685000588	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685000589	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685000590	active site
710685000591	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685000592	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685000593	active site
710685000594	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
710685000595	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
710685000596	NADP binding site [chemical binding]; other site
710685000597	dimer interface [polypeptide binding]; other site
710685000598	Predicted esterase [General function prediction only]; Region: COG0627
710685000599	Helix-turn-helix domains; Region: HTH; cl00088
710685000600	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685000601	active site
710685000602	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685000603	Cupin domain; Region: Cupin_2; cl09118
710685000604	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685000605	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
710685000606	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685000607	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685000608	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
710685000609	active site
710685000610	catalytic residues [active]
710685000611	metal binding site [ion binding]; metal-binding site
710685000612	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685000613	Helix-turn-helix domains; Region: HTH; cl00088
710685000614	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685000615	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685000616	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
710685000617	active site
710685000618	Phosphotransferase enzyme family; Region: APH; pfam01636
710685000619	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
710685000620	putative active site [active]
710685000621	putative substrate binding site [chemical binding]; other site
710685000622	ATP binding site [chemical binding]; other site
710685000623	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685000624	S-adenosylmethionine binding site [chemical binding]; other site
710685000625	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685000626	YceI-like domain; Region: YceI; cl01001
710685000627	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
710685000628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685000629	active site
710685000630	phosphorylation site [posttranslational modification]
710685000631	intermolecular recognition site; other site
710685000632	dimerization interface [polypeptide binding]; other site
710685000633	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
710685000634	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
710685000635	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
710685000636	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
710685000637	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
710685000638	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
710685000639	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
710685000640	putative dimer interface [polypeptide binding]; other site
710685000641	[2Fe-2S] cluster binding site [ion binding]; other site
710685000642	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
710685000643	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
710685000644	SLBB domain; Region: SLBB; pfam10531
710685000645	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
710685000646	NADH dehydrogenase subunit G; Validated; Region: PRK07860
710685000647	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685000648	catalytic loop [active]
710685000649	iron binding site [ion binding]; other site
710685000650	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
710685000651	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
710685000652	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
710685000653	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
710685000654	NADH dehydrogenase; Region: NADHdh; cl00469
710685000655	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
710685000656	4Fe-4S binding domain; Region: Fer4; cl02805
710685000657	4Fe-4S binding domain; Region: Fer4; cl02805
710685000658	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
710685000659	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
710685000660	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
710685000661	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
710685000662	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
710685000663	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
710685000664	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
710685000665	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
710685000666	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
710685000667	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
710685000668	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
710685000669	enoyl-CoA hydratase; Provisional; Region: PRK06190
710685000670	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685000671	substrate binding site [chemical binding]; other site
710685000672	oxyanion hole (OAH) forming residues; other site
710685000673	trimer interface [polypeptide binding]; other site
710685000674	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
710685000675	putative di-iron ligands [ion binding]; other site
710685000676	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685000677	Fatty acid desaturase; Region: FA_desaturase; pfam00487
710685000678	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
710685000679	Di-iron ligands [ion binding]; other site
710685000680	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
710685000681	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
710685000682	Fatty acid desaturase; Region: FA_desaturase; pfam00487
710685000683	Di-iron ligands [ion binding]; other site
710685000684	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
710685000685	acyl-CoA synthetase; Validated; Region: PRK05850
710685000686	AMP-binding enzyme; Region: AMP-binding; cl15778
710685000687	Cytochrome P450; Region: p450; pfam00067
710685000688	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685000689	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685000690	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
710685000691	AMP-binding enzyme; Region: AMP-binding; cl15778
710685000692	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
710685000693	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
710685000694	Walker A/P-loop; other site
710685000695	ATP binding site [chemical binding]; other site
710685000696	Q-loop/lid; other site
710685000697	ABC transporter signature motif; other site
710685000698	Walker B; other site
710685000699	D-loop; other site
710685000700	H-loop/switch region; other site
710685000701	ABC-2 type transporter; Region: ABC2_membrane; cl11417
710685000702	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
710685000703	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685000704	nucleophilic elbow; other site
710685000705	catalytic triad; other site
710685000706	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685000707	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
710685000708	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
710685000709	active site
710685000710	Acyl transferase domain; Region: Acyl_transf_1; cl08282
710685000711	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
710685000712	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685000713	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
710685000714	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685000715	Helix-turn-helix domains; Region: HTH; cl00088
710685000716	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
710685000717	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
710685000718	putative active site [active]
710685000719	putative substrate binding site [chemical binding]; other site
710685000720	ATP binding site [chemical binding]; other site
710685000721	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
710685000722	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685000723	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685000724	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685000725	Putative exonuclease, RdgC; Region: RdgC; cl01122
710685000726	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
710685000727	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
710685000728	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
710685000729	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000730	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685000731	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685000732	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
710685000733	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
710685000734	NAD(P) binding site [chemical binding]; other site
710685000735	Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080
710685000736	putative catalytic site [active]
710685000737	putative metal binding site [ion binding]; other site
710685000738	putative phosphate binding site [ion binding]; other site
710685000739	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685000740	heat shock protein 90; Provisional; Region: PRK05218
710685000741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
710685000742	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
710685000743	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
710685000744	homodimer interface [polypeptide binding]; other site
710685000745	active site
710685000746	TDP-binding site; other site
710685000747	acceptor substrate-binding pocket; other site
710685000748	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
710685000749	AMP-binding enzyme; Region: AMP-binding; cl15778
710685000750	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685000751	Condensation domain; Region: Condensation; pfam00668
710685000752	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
710685000753	Condensation domain; Region: Condensation; pfam00668
710685000754	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
710685000755	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685000756	AMP-binding enzyme; Region: AMP-binding; cl15778
710685000757	acyl-CoA synthetase; Validated; Region: PRK08308
710685000758	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685000759	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
710685000760	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
710685000761	putative NAD(P) binding site [chemical binding]; other site
710685000762	active site
710685000763	putative substrate binding site [chemical binding]; other site
710685000764	peptide synthase; Provisional; Region: PRK12467
710685000765	AMP-binding enzyme; Region: AMP-binding; cl15778
710685000766	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685000767	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
710685000768	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685000769	AMP-binding enzyme; Region: AMP-binding; cl15778
710685000770	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685000771	Condensation domain; Region: Condensation; pfam00668
710685000772	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
710685000773	Condensation domain; Region: Condensation; pfam00668
710685000774	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
710685000775	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685000776	MbtH-like protein; Region: MbtH; cl01279
710685000777	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
710685000778	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
710685000779	homodimer interface [polypeptide binding]; other site
710685000780	active site
710685000781	TDP-binding site; other site
710685000782	acceptor substrate-binding pocket; other site
710685000783	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685000784	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
710685000785	Walker A/P-loop; other site
710685000786	ATP binding site [chemical binding]; other site
710685000787	Q-loop/lid; other site
710685000788	ABC transporter signature motif; other site
710685000789	Walker B; other site
710685000790	D-loop; other site
710685000791	H-loop/switch region; other site
710685000792	ABC-2 type transporter; Region: ABC2_membrane; cl11417
710685000793	ABC-2 type transporter; Region: ABC2_membrane; cl11417
710685000794	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
710685000795	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
710685000796	metal-binding site
710685000797	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000798	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
710685000799	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
710685000800	NADP binding site [chemical binding]; other site
710685000801	active site
710685000802	putative substrate binding site [chemical binding]; other site
710685000803	GDP-mannose 4,6-dehydratase; Region: PLN02653
710685000804	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
710685000805	NADP-binding site; other site
710685000806	homotetramer interface [polypeptide binding]; other site
710685000807	substrate binding site [chemical binding]; other site
710685000808	homodimer interface [polypeptide binding]; other site
710685000809	active site
710685000810	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
710685000811	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
710685000812	trimer interface [polypeptide binding]; other site
710685000813	active site
710685000814	substrate binding site [chemical binding]; other site
710685000815	CoA binding site [chemical binding]; other site
710685000816	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
710685000817	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000818	NAD(P) binding site [chemical binding]; other site
710685000819	active site
710685000820	WbqC-like protein family; Region: WbqC; pfam08889
710685000821	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685000822	S-adenosylmethionine binding site [chemical binding]; other site
710685000823	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000824	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
710685000825	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
710685000826	Ligand binding site; other site
710685000827	Putative Catalytic site; other site
710685000828	DXD motif; other site
710685000829	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
710685000830	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
710685000831	inhibitor-cofactor binding pocket; inhibition site
710685000832	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685000833	catalytic residue [active]
710685000834	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
710685000835	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
710685000836	homodimer interface [polypeptide binding]; other site
710685000837	active site
710685000838	TDP-binding site; other site
710685000839	acceptor substrate-binding pocket; other site
710685000840	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000841	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000842	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
710685000843	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
710685000844	homodimer interface [polypeptide binding]; other site
710685000845	active site
710685000846	TDP-binding site; other site
710685000847	acceptor substrate-binding pocket; other site
710685000848	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
710685000849	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
710685000850	homodimer interface [polypeptide binding]; other site
710685000851	active site
710685000852	TDP-binding site; other site
710685000853	acceptor substrate-binding pocket; other site
710685000854	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000855	OpgC protein; Region: OpgC_C; cl00792
710685000856	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
710685000857	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000858	NAD(P) binding site [chemical binding]; other site
710685000859	active site
710685000860	Transport protein; Region: actII; TIGR00833
710685000861	Transport protein; Region: actII; TIGR00833
710685000862	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
710685000863	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685000864	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685000865	Putative sensor; Region: Sensor; pfam13796
710685000866	Histidine kinase; Region: HisKA_3; pfam07730
710685000867	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685000868	ATP binding site [chemical binding]; other site
710685000869	Mg2+ binding site [ion binding]; other site
710685000870	G-X-G motif; other site
710685000871	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
710685000872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685000873	active site
710685000874	phosphorylation site [posttranslational modification]
710685000875	intermolecular recognition site; other site
710685000876	dimerization interface [polypeptide binding]; other site
710685000877	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685000878	DNA binding residues [nucleotide binding]
710685000879	dimerization interface [polypeptide binding]; other site
710685000880	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
710685000881	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
710685000882	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
710685000883	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
710685000884	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
710685000885	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
710685000886	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
710685000887	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685000888	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
710685000889	active site
710685000890	ATP binding site [chemical binding]; other site
710685000891	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
710685000892	Family description; Region: UvrD_C_2; cl15862
710685000893	HRDC domain; Region: HRDC; cl02578
710685000894	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
710685000895	catalytic residues [active]
710685000896	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
710685000897	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
710685000898	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
710685000899	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
710685000900	putative NADH binding site [chemical binding]; other site
710685000901	putative active site [active]
710685000902	nudix motif; other site
710685000903	putative metal binding site [ion binding]; other site
710685000904	Ion channel; Region: Ion_trans_2; cl11596
710685000905	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
710685000906	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000907	Predicted membrane protein [Function unknown]; Region: COG4270
710685000908	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
710685000909	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685000910	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
710685000911	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
710685000912	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
710685000913	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
710685000914	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
710685000915	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685000916	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685000917	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
710685000918	active site
710685000919	DNA binding site [nucleotide binding]
710685000920	TIGR02569 family protein; Region: TIGR02569_actnb
710685000921	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
710685000922	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
710685000923	ATP binding site [chemical binding]; other site
710685000924	substrate interface [chemical binding]; other site
710685000925	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
710685000926	active site residue [active]
710685000927	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
710685000928	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685000929	Helix-turn-helix domains; Region: HTH; cl00088
710685000930	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
710685000931	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
710685000932	dinuclear metal binding motif [ion binding]; other site
710685000933	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
710685000934	DEAD-like helicases superfamily; Region: DEXDc; smart00487
710685000935	ATP binding site [chemical binding]; other site
710685000936	Mg++ binding site [ion binding]; other site
710685000937	motif III; other site
710685000938	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685000939	nucleotide binding region [chemical binding]; other site
710685000940	ATP-binding site [chemical binding]; other site
710685000941	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
710685000942	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
710685000943	P-loop; other site
710685000944	Magnesium ion binding site [ion binding]; other site
710685000945	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
710685000946	Magnesium ion binding site [ion binding]; other site
710685000947	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
710685000948	catalytic core [active]
710685000949	chorismate binding enzyme; Region: Chorismate_bind; cl10555
710685000950	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685000951	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
710685000952	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
710685000953	Transcription factor WhiB; Region: Whib; pfam02467
710685000954	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
710685000955	sensory histidine kinase AtoS; Provisional; Region: PRK11360
710685000956	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
710685000957	Histidine kinase; Region: HisKA_2; cl06527
710685000958	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685000959	ATP binding site [chemical binding]; other site
710685000960	Mg2+ binding site [ion binding]; other site
710685000961	G-X-G motif; other site
710685000962	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
710685000963	carboxyltransferase (CT) interaction site; other site
710685000964	biotinylation site [posttranslational modification]; other site
710685000965	Putative zinc-finger; Region: zf-HC2; cl15806
710685000966	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
710685000967	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685000968	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685000969	DNA binding residues [nucleotide binding]
710685000970	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
710685000971	putative deacylase active site [active]
710685000972	short chain dehydrogenase; Provisional; Region: PRK08278
710685000973	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685000974	NAD(P) binding site [chemical binding]; other site
710685000975	active site
710685000976	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
710685000977	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
710685000978	NAD binding site [chemical binding]; other site
710685000979	catalytic Zn binding site [ion binding]; other site
710685000980	substrate binding site [chemical binding]; other site
710685000981	structural Zn binding site [ion binding]; other site
710685000982	Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329
710685000983	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685000984	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685000985	substrate binding site [chemical binding]; other site
710685000986	oxyanion hole (OAH) forming residues; other site
710685000987	trimer interface [polypeptide binding]; other site
710685000988	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685000989	Helix-turn-helix domains; Region: HTH; cl00088
710685000990	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
710685000991	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
710685000992	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
710685000993	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
710685000994	hinge; other site
710685000995	active site
710685000996	Predicted GTPases [General function prediction only]; Region: COG1162
710685000997	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
710685000998	GTPase/Zn-binding domain interface [polypeptide binding]; other site
710685000999	GTP/Mg2+ binding site [chemical binding]; other site
710685001000	G4 box; other site
710685001001	G5 box; other site
710685001002	G1 box; other site
710685001003	Switch I region; other site
710685001004	G2 box; other site
710685001005	G3 box; other site
710685001006	Switch II region; other site
710685001007	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
710685001008	putative active site [active]
710685001009	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
710685001010	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
710685001011	putative di-iron ligands [ion binding]; other site
710685001012	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
710685001013	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
710685001014	FAD binding pocket [chemical binding]; other site
710685001015	FAD binding motif [chemical binding]; other site
710685001016	phosphate binding motif [ion binding]; other site
710685001017	beta-alpha-beta structure motif; other site
710685001018	NAD binding pocket [chemical binding]; other site
710685001019	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685001020	catalytic loop [active]
710685001021	iron binding site [ion binding]; other site
710685001022	BCCT family transporter; Region: BCCT; cl00569
710685001023	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685001024	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685001025	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685001026	hydrophobic ligand binding site; other site
710685001027	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
710685001028	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685001029	ATP binding site [chemical binding]; other site
710685001030	putative Mg++ binding site [ion binding]; other site
710685001031	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
710685001032	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685001033	nucleotide binding region [chemical binding]; other site
710685001034	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
710685001035	30S subunit binding site; other site
710685001036	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
710685001037	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
710685001038	active site
710685001039	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
710685001040	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
710685001041	iron-sulfur cluster [ion binding]; other site
710685001042	[2Fe-2S] cluster binding site [ion binding]; other site
710685001043	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
710685001044	lipoprotein LpqB; Provisional; Region: PRK13616
710685001045	Sporulation and spore germination; Region: Germane; cl11253
710685001046	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
710685001047	dimerization interface [polypeptide binding]; other site
710685001048	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685001049	dimer interface [polypeptide binding]; other site
710685001050	phosphorylation site [posttranslational modification]
710685001051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685001052	ATP binding site [chemical binding]; other site
710685001053	Mg2+ binding site [ion binding]; other site
710685001054	G-X-G motif; other site
710685001055	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685001056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685001057	active site
710685001058	phosphorylation site [posttranslational modification]
710685001059	intermolecular recognition site; other site
710685001060	dimerization interface [polypeptide binding]; other site
710685001061	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685001062	DNA binding site [nucleotide binding]
710685001063	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
710685001064	putative active site [active]
710685001065	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685001066	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685001067	active site
710685001068	ATP binding site [chemical binding]; other site
710685001069	substrate binding site [chemical binding]; other site
710685001070	activation loop (A-loop); other site
710685001071	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
710685001072	Helix-turn-helix domains; Region: HTH; cl00088
710685001073	DNA binding site [nucleotide binding]
710685001074	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685001075	phosphopeptide binding site; other site
710685001076	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
710685001077	Thymidylate kinase; Region: Thymidylate_kin; pfam02223
710685001078	TMP-binding site; other site
710685001079	ATP-binding site [chemical binding]; other site
710685001080	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
710685001081	Secretory lipase; Region: LIP; pfam03583
710685001082	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
710685001083	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401
710685001084	oligomerization interface [polypeptide binding]; other site
710685001085	active site
710685001086	NAD+ binding site [chemical binding]; other site
710685001087	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685001088	Helix-turn-helix domains; Region: HTH; cl00088
710685001089	Rubredoxin [Energy production and conversion]; Region: COG1773
710685001090	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
710685001091	iron binding site [ion binding]; other site
710685001092	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
710685001093	Rubredoxin; Region: Rubredoxin; pfam00301
710685001094	iron binding site [ion binding]; other site
710685001095	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
710685001096	Fatty acid desaturase; Region: FA_desaturase; pfam00487
710685001097	Di-iron ligands [ion binding]; other site
710685001098	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
710685001099	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
710685001100	amino acid transporter; Region: 2A0306; TIGR00909
710685001101	Spore germination protein; Region: Spore_permease; cl15802
710685001102	Spore germination protein; Region: Spore_permease; cl15802
710685001103	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
710685001104	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685001105	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
710685001106	Phosphomannose isomerase type I; Region: PMI_typeI; cl15429
710685001107	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
710685001108	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
710685001109	active site
710685001110	substrate binding site [chemical binding]; other site
710685001111	metal binding site [ion binding]; metal-binding site
710685001112	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
710685001113	Possibl zinc metallo-peptidase; Region: DUF1025; cl01577
710685001114	Transcription factor WhiB; Region: Whib; pfam02467
710685001115	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
710685001116	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
710685001117	dimer interface [polypeptide binding]; other site
710685001118	substrate binding site [chemical binding]; other site
710685001119	phosphate binding site [ion binding]; other site
710685001120	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
710685001121	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
710685001122	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
710685001123	putative FMN binding site [chemical binding]; other site
710685001124	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
710685001125	nudix motif; other site
710685001126	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
710685001127	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
710685001128	active site
710685001129	Substrate binding site; other site
710685001130	Mg++ binding site; other site
710685001131	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
710685001132	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
710685001133	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
710685001134	Probable Catalytic site; other site
710685001135	metal-binding site
710685001136	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
710685001137	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
710685001138	NADP binding site [chemical binding]; other site
710685001139	active site
710685001140	putative substrate binding site [chemical binding]; other site
710685001141	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
710685001142	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
710685001143	AMP-binding enzyme; Region: AMP-binding; cl15778
710685001144	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
710685001145	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
710685001146	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
710685001147	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
710685001148	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685001149	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
710685001150	FAD binding site [chemical binding]; other site
710685001151	homotetramer interface [polypeptide binding]; other site
710685001152	substrate binding pocket [chemical binding]; other site
710685001153	catalytic base [active]
710685001154	AIR carboxylase; Region: AIRC; cl00310
710685001155	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
710685001156	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685001157	GtrA-like protein; Region: GtrA; cl00971
710685001158	Bacterial PH domain; Region: DUF304; cl01348
710685001159	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
710685001160	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
710685001161	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
710685001162	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
710685001163	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685001164	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685001165	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
710685001166	putative active site [active]
710685001167	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
710685001168	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
710685001169	active site residue [active]
710685001170	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
710685001171	active site residue [active]
710685001172	Fe-S metabolism associated domain; Region: SufE; cl00951
710685001173	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685001174	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685001175	NAD(P) binding site [chemical binding]; other site
710685001176	active site
710685001177	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685001178	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
710685001179	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
710685001180	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685001181	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
710685001182	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
710685001183	carboxyltransferase (CT) interaction site; other site
710685001184	biotinylation site [posttranslational modification]; other site
710685001185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685001186	NADH(P)-binding; Region: NAD_binding_10; pfam13460
710685001187	NAD(P) binding site [chemical binding]; other site
710685001188	active site
710685001189	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
710685001190	metal-binding site
710685001191	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
710685001192	anti sigma factor interaction site; other site
710685001193	regulatory phosphorylation site [posttranslational modification]; other site
710685001194	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
710685001195	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685001196	active site
710685001197	DNA binding site [nucleotide binding]
710685001198	Int/Topo IB signature motif; other site
710685001199	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
710685001200	Restriction endonuclease; Region: Mrr_cat; cl00516
710685001201	L-lysine aminotransferase; Provisional; Region: PRK08297
710685001202	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
710685001203	inhibitor-cofactor binding pocket; inhibition site
710685001204	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685001205	catalytic residue [active]
710685001206	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
710685001207	Helix-turn-helix domains; Region: HTH; cl00088
710685001208	Domain of unknown function (DUF1338); Region: DUF1338; cl02226
710685001209	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
710685001210	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685001211	tetrameric interface [polypeptide binding]; other site
710685001212	NAD binding site [chemical binding]; other site
710685001213	catalytic residues [active]
710685001214	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685001215	Helix-turn-helix domains; Region: HTH; cl00088
710685001216	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
710685001217	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
710685001218	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
710685001219	ATP binding site [chemical binding]; other site
710685001220	putative Mg++ binding site [ion binding]; other site
710685001221	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685001222	nucleotide binding region [chemical binding]; other site
710685001223	ATP-binding site [chemical binding]; other site
710685001224	DEAD/H associated; Region: DEAD_assoc; pfam08494
710685001225	Protein of unknown function (DUF1006); Region: DUF1006; cl15826
710685001226	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
710685001227	FMN binding site [chemical binding]; other site
710685001228	putative catalytic residue [active]
710685001229	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
710685001230	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
710685001231	putative DNA binding site [nucleotide binding]; other site
710685001232	catalytic residue [active]
710685001233	putative H2TH interface [polypeptide binding]; other site
710685001234	putative catalytic residues [active]
710685001235	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
710685001236	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
710685001237	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
710685001238	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
710685001239	putative di-iron ligands [ion binding]; other site
710685001240	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
710685001241	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
710685001242	FAD binding pocket [chemical binding]; other site
710685001243	FAD binding motif [chemical binding]; other site
710685001244	phosphate binding motif [ion binding]; other site
710685001245	beta-alpha-beta structure motif; other site
710685001246	NAD binding pocket [chemical binding]; other site
710685001247	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685001248	catalytic loop [active]
710685001249	iron binding site [ion binding]; other site
710685001250	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
710685001251	Helix-turn-helix domains; Region: HTH; cl00088
710685001252	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685001253	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685001254	substrate binding site [chemical binding]; other site
710685001255	oxyanion hole (OAH) forming residues; other site
710685001256	trimer interface [polypeptide binding]; other site
710685001257	classical (c) SDRs; Region: SDR_c; cd05233
710685001258	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
710685001259	NAD(P) binding site [chemical binding]; other site
710685001260	active site
710685001261	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
710685001262	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
710685001263	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
710685001264	PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558
710685001265	probable active site [active]
710685001266	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
710685001267	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
710685001268	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685001269	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685001270	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
710685001271	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
710685001272	putative active site pocket [active]
710685001273	dimerization interface [polypeptide binding]; other site
710685001274	putative catalytic residue [active]
710685001275	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
710685001276	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
710685001277	Helix-turn-helix domains; Region: HTH; cl00088
710685001278	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
710685001279	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
710685001280	metal binding site [ion binding]; metal-binding site
710685001281	putative dimer interface [polypeptide binding]; other site
710685001282	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
710685001283	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
710685001284	metal binding site [ion binding]; metal-binding site
710685001285	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
710685001286	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
710685001287	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
710685001288	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
710685001289	Helix-turn-helix domains; Region: HTH; cl00088
710685001290	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
710685001291	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
710685001292	active site
710685001293	substrate binding site [chemical binding]; other site
710685001294	metal binding site [ion binding]; metal-binding site
710685001295	putative succinate dehydrogenase; Reviewed; Region: PRK12842
710685001296	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
710685001297	active site
710685001298	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
710685001299	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
710685001300	active site
710685001301	NlpC/P60 family; Region: NLPC_P60; cl11438
710685001302	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
710685001303	putative acyl-acceptor binding pocket; other site
710685001304	Permease; Region: Permease; cl00510
710685001305	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
710685001306	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685001307	active site
710685001308	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
710685001309	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
710685001310	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
710685001311	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
710685001312	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
710685001313	active site
710685001314	catalytic motif [active]
710685001315	Zn binding site [ion binding]; other site
710685001316	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
710685001317	putative Iron-sulfur protein interface [polypeptide binding]; other site
710685001318	putative proximal heme binding site [chemical binding]; other site
710685001319	putative SdhD-like interface [polypeptide binding]; other site
710685001320	putative distal heme binding site [chemical binding]; other site
710685001321	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
710685001322	putative Iron-sulfur protein interface [polypeptide binding]; other site
710685001323	putative proximal heme binding site [chemical binding]; other site
710685001324	putative SdhC-like subunit interface [polypeptide binding]; other site
710685001325	putative distal heme binding site [chemical binding]; other site
710685001326	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
710685001327	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685001328	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
710685001329	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
710685001330	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
710685001331	Uncharacterized conserved protein [Function unknown]; Region: COG2128
710685001332	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
710685001333	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685001334	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685001335	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
710685001336	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685001337	Ligand Binding Site [chemical binding]; other site
710685001338	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685001339	Ligand Binding Site [chemical binding]; other site
710685001340	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
710685001341	Spore germination protein; Region: Spore_permease; cl15802
710685001342	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
710685001343	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685001344	NAD(P) binding site [chemical binding]; other site
710685001345	catalytic residues [active]
710685001346	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
710685001347	Helix-turn-helix domains; Region: HTH; cl00088
710685001348	hypothetical protein; Provisional; Region: PRK06541
710685001349	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
710685001350	inhibitor-cofactor binding pocket; inhibition site
710685001351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685001352	catalytic residue [active]
710685001353	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
710685001354	Strictosidine synthase; Region: Str_synth; pfam03088
710685001355	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
710685001356	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685001357	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
710685001358	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
710685001359	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
710685001360	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
710685001361	active site
710685001362	HIGH motif; other site
710685001363	dimer interface [polypeptide binding]; other site
710685001364	KMSKS motif; other site
710685001365	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685001366	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
710685001367	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
710685001368	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
710685001369	homodimer interface [polypeptide binding]; other site
710685001370	substrate-cofactor binding pocket; other site
710685001371	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685001372	catalytic residue [active]
710685001373	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685001374	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
710685001375	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
710685001376	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685001377	S-adenosylmethionine binding site [chemical binding]; other site
710685001378	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
710685001379	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
710685001380	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
710685001381	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
710685001382	homodimer interface [polypeptide binding]; other site
710685001383	NADP binding site [chemical binding]; other site
710685001384	substrate binding site [chemical binding]; other site
710685001385	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
710685001386	active site
710685001387	FMN binding site [chemical binding]; other site
710685001388	substrate binding site [chemical binding]; other site
710685001389	putative catalytic residue [active]
710685001390	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685001391	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685001392	phosphopeptide binding site; other site
710685001393	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685001394	phosphopeptide binding site; other site
710685001395	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
710685001396	ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213
710685001397	Walker A/P-loop; other site
710685001398	ATP binding site [chemical binding]; other site
710685001399	Q-loop/lid; other site
710685001400	ABC transporter signature motif; other site
710685001401	Walker B; other site
710685001402	D-loop; other site
710685001403	H-loop/switch region; other site
710685001404	ABC-2 type transporter; Region: ABC2_membrane; cl11417
710685001405	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685001406	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685001407	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685001408	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
710685001409	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
710685001410	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
710685001411	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
710685001412	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
710685001413	G1 box; other site
710685001414	GTP/Mg2+ binding site [chemical binding]; other site
710685001415	G2 box; other site
710685001416	Switch I region; other site
710685001417	G3 box; other site
710685001418	Switch II region; other site
710685001419	G4 box; other site
710685001420	G5 box; other site
710685001421	Protein of unknown function (DUF742); Region: DUF742; pfam05331
710685001422	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
710685001423	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
710685001424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685001425	ATP binding site [chemical binding]; other site
710685001426	Mg2+ binding site [ion binding]; other site
710685001427	G-X-G motif; other site
710685001428	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
710685001429	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
710685001430	FMN binding site [chemical binding]; other site
710685001431	dimer interface [polypeptide binding]; other site
710685001432	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685001433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685001434	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
710685001435	putative substrate translocation pore; other site
710685001436	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
710685001437	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
710685001438	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
710685001439	generic binding surface II; other site
710685001440	generic binding surface I; other site
710685001441	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685001442	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685001443	active site
710685001444	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
710685001445	Spore germination protein; Region: Spore_permease; cl15802
710685001446	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685001447	Ligand Binding Site [chemical binding]; other site
710685001448	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685001449	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
710685001450	dimer interaction site [polypeptide binding]; other site
710685001451	substrate-binding tunnel; other site
710685001452	active site
710685001453	catalytic site [active]
710685001454	substrate binding site [chemical binding]; other site
710685001455	short chain dehydrogenase; Provisional; Region: PRK07201
710685001456	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
710685001457	putative NAD(P) binding site [chemical binding]; other site
710685001458	active site
710685001459	putative substrate binding site [chemical binding]; other site
710685001460	classical (c) SDRs; Region: SDR_c; cd05233
710685001461	NAD(P) binding site [chemical binding]; other site
710685001462	active site
710685001463	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
710685001464	active site
710685001465	DNA Polymerase Y-family; Region: PolY_like; cd03468
710685001466	DNA binding site [nucleotide binding]
710685001467	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685001468	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685001469	classical (c) SDRs; Region: SDR_c; cd05233
710685001470	short chain dehydrogenase; Provisional; Region: PRK05650
710685001471	NAD(P) binding site [chemical binding]; other site
710685001472	active site
710685001473	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
710685001474	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685001475	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685001476	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778
710685001477	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
710685001478	DNA binding residues [nucleotide binding]
710685001479	putative dimer interface [polypeptide binding]; other site
710685001480	GMP synthase; Reviewed; Region: guaA; PRK00074
710685001481	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
710685001482	AMP/PPi binding site [chemical binding]; other site
710685001483	candidate oxyanion hole; other site
710685001484	catalytic triad [active]
710685001485	potential glutamine specificity residues [chemical binding]; other site
710685001486	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
710685001487	ATP Binding subdomain [chemical binding]; other site
710685001488	Ligand Binding sites [chemical binding]; other site
710685001489	Dimerization subdomain; other site
710685001490	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
710685001491	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
710685001492	active site
710685001493	non-prolyl cis peptide bond; other site
710685001494	Sodium:solute symporter family; Region: SSF; cl00456
710685001495	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685001496	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
710685001497	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
710685001498	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
710685001499	dimer interface [polypeptide binding]; other site
710685001500	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685001501	catalytic residue [active]
710685001502	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685001503	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
710685001504	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
710685001505	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685001506	motif II; other site
710685001507	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
710685001508	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
710685001509	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
710685001510	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
710685001511	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
710685001512	PhoU domain; Region: PhoU; pfam01895
710685001513	PhoU domain; Region: PhoU; pfam01895
710685001514	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
710685001515	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685001516	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
710685001517	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
710685001518	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
710685001519	phosphate binding site [ion binding]; other site
710685001520	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
710685001521	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
710685001522	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
710685001523	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
710685001524	active site
710685001525	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
710685001526	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685001527	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685001528	DNA binding residues [nucleotide binding]
710685001529	Transcription factor WhiB; Region: Whib; pfam02467
710685001530	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
710685001531	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
710685001532	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
710685001533	putative NAD(P) binding site [chemical binding]; other site
710685001534	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
710685001535	dimerization interface [polypeptide binding]; other site
710685001536	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
710685001537	cyclase homology domain; Region: CHD; cd07302
710685001538	nucleotidyl binding site; other site
710685001539	metal binding site [ion binding]; metal-binding site
710685001540	dimer interface [polypeptide binding]; other site
710685001541	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
710685001542	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
710685001543	ring oligomerisation interface [polypeptide binding]; other site
710685001544	ATP/Mg binding site [chemical binding]; other site
710685001545	stacking interactions; other site
710685001546	hinge regions; other site
710685001547	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
710685001548	oligomerisation interface [polypeptide binding]; other site
710685001549	mobile loop; other site
710685001550	roof hairpin; other site
710685001551	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685001552	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685001553	UGMP family protein; Validated; Region: PRK09604
710685001554	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
710685001555	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
710685001556	Coenzyme A binding pocket [chemical binding]; other site
710685001557	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685001558	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
710685001559	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
710685001560	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685001561	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685001562	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685001563	alanine racemase; Reviewed; Region: alr; PRK00053
710685001564	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
710685001565	active site
710685001566	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
710685001567	dimer interface [polypeptide binding]; other site
710685001568	substrate binding site [chemical binding]; other site
710685001569	catalytic residues [active]
710685001570	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
710685001571	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
710685001572	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685001573	catalytic residue [active]
710685001574	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
710685001575	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
710685001576	putative substrate binding site [chemical binding]; other site
710685001577	putative ATP binding site [chemical binding]; other site
710685001578	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
710685001579	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
710685001580	glutaminase active site [active]
710685001581	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
710685001582	dimer interface [polypeptide binding]; other site
710685001583	active site
710685001584	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
710685001585	dimer interface [polypeptide binding]; other site
710685001586	active site
710685001587	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
710685001588	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685001589	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
710685001590	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
710685001591	DEAD-like helicases superfamily; Region: DEXDc; smart00487
710685001592	ATP binding site [chemical binding]; other site
710685001593	Mg++ binding site [ion binding]; other site
710685001594	motif III; other site
710685001595	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685001596	nucleotide binding region [chemical binding]; other site
710685001597	ATP-binding site [chemical binding]; other site
710685001598	Winged helix-turn helix; Region: HTH_29; pfam13551
710685001599	Integrase core domain; Region: rve; cl01316
710685001600	Integrase core domain; Region: rve_3; cl15866
710685001601	Transposase; Region: DEDD_Tnp_IS110; pfam01548
710685001602	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
710685001603	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685001604	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685001605	active site
710685001606	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
710685001607	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
710685001608	active site
710685001609	substrate binding site [chemical binding]; other site
710685001610	metal binding site [ion binding]; metal-binding site
710685001611	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
710685001612	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
710685001613	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
710685001614	23S rRNA interface [nucleotide binding]; other site
710685001615	L3 interface [polypeptide binding]; other site
710685001616	Proteins of 100 residues with WXG; Region: WXG100; cl02005
710685001617	Proteins of 100 residues with WXG; Region: WXG100; cl02005
710685001618	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
710685001619	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
710685001620	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685001621	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
710685001622	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685001623	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685001624	Ubiquitin-like proteins; Region: UBQ; cl00155
710685001625	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
710685001626	active site
710685001627	catalytic residues [active]
710685001628	Protein of unknown function (DUF690); Region: DUF690; cl04939
710685001629	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
710685001630	CGNR zinc finger; Region: zf-CGNR; pfam11706
710685001631	EamA-like transporter family; Region: EamA; cl01037
710685001632	EamA-like transporter family; Region: EamA; cl01037
710685001633	Cutinase; Region: Cutinase; pfam01083
710685001634	Cutinase; Region: Cutinase; pfam01083
710685001635	Cutinase; Region: Cutinase; pfam01083
710685001636	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
710685001637	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
710685001638	dimerization interface 3.5A [polypeptide binding]; other site
710685001639	active site
710685001640	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
710685001641	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
710685001642	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
710685001643	alphaNTD homodimer interface [polypeptide binding]; other site
710685001644	alphaNTD - beta interaction site [polypeptide binding]; other site
710685001645	alphaNTD - beta' interaction site [polypeptide binding]; other site
710685001646	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
710685001647	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
710685001648	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
710685001649	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
710685001650	RNA binding surface [nucleotide binding]; other site
710685001651	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
710685001652	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
710685001653	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
710685001654	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
710685001655	rRNA binding site [nucleotide binding]; other site
710685001656	predicted 30S ribosome binding site; other site
710685001657	Response regulator receiver domain; Region: Response_reg; pfam00072
710685001658	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685001659	active site
710685001660	phosphorylation site [posttranslational modification]
710685001661	intermolecular recognition site; other site
710685001662	dimerization interface [polypeptide binding]; other site
710685001663	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
710685001664	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685001665	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
710685001666	ligand binding site [chemical binding]; other site
710685001667	flexible hinge region; other site
710685001668	histidine kinase; Provisional; Region: PRK13557
710685001669	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685001670	ATP binding site [chemical binding]; other site
710685001671	Mg2+ binding site [ion binding]; other site
710685001672	G-X-G motif; other site
710685001673	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685001674	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
710685001675	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685001676	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
710685001677	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
710685001678	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
710685001679	dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181
710685001680	NAD binding site [chemical binding]; other site
710685001681	substrate binding site [chemical binding]; other site
710685001682	homodimer interface [polypeptide binding]; other site
710685001683	active site
710685001684	Cupin domain; Region: Cupin_2; cl09118
710685001685	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
710685001686	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685001687	tetrameric interface [polypeptide binding]; other site
710685001688	NAD binding site [chemical binding]; other site
710685001689	catalytic residues [active]
710685001690	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685001691	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
710685001692	substrate binding pocket [chemical binding]; other site
710685001693	FAD binding site [chemical binding]; other site
710685001694	catalytic base [active]
710685001695	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685001696	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
710685001697	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685001698	haloacid dehalogenase-like hydrolase family protein; Region: PLN02779
710685001699	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685001700	motif II; other site
710685001701	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
710685001702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685001703	active site
710685001704	phosphorylation site [posttranslational modification]
710685001705	intermolecular recognition site; other site
710685001706	dimerization interface [polypeptide binding]; other site
710685001707	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685001708	DNA binding residues [nucleotide binding]
710685001709	dimerization interface [polypeptide binding]; other site
710685001710	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
710685001711	GAF domain; Region: GAF; cl15785
710685001712	Histidine kinase; Region: HisKA_3; pfam07730
710685001713	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685001714	ATP binding site [chemical binding]; other site
710685001715	Mg2+ binding site [ion binding]; other site
710685001716	G-X-G motif; other site
710685001717	Helix-turn-helix domains; Region: HTH; cl00088
710685001718	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685001719	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
710685001720	active site
710685001721	metal binding site [ion binding]; metal-binding site
710685001722	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
710685001723	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
710685001724	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685001725	homodimer interface [polypeptide binding]; other site
710685001726	catalytic residue [active]
710685001727	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
710685001728	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
710685001729	active site
710685001730	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
710685001731	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
710685001732	PYR/PP interface [polypeptide binding]; other site
710685001733	dimer interface [polypeptide binding]; other site
710685001734	TPP binding site [chemical binding]; other site
710685001735	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
710685001736	TPP-binding site [chemical binding]; other site
710685001737	Putative zinc-finger; Region: zf-HC2; cl15806
710685001738	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
710685001739	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685001740	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685001741	DNA binding residues [nucleotide binding]
710685001742	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
710685001743	active site
710685001744	adenylate kinase; Reviewed; Region: adk; PRK00279
710685001745	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
710685001746	AMP-binding site [chemical binding]; other site
710685001747	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
710685001748	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
710685001749	SecY translocase; Region: SecY; pfam00344
710685001750	Leucine carboxyl methyltransferase; Region: LCM; cl01306
710685001751	Leucine carboxyl methyltransferase; Region: LCM; cl01306
710685001752	Leucine carboxyl methyltransferase; Region: LCM; cl01306
710685001753	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
710685001754	N- and C-terminal domain interface [polypeptide binding]; other site
710685001755	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
710685001756	active site
710685001757	MgATP binding site [chemical binding]; other site
710685001758	catalytic site [active]
710685001759	metal binding site [ion binding]; metal-binding site
710685001760	carbohydrate binding site [chemical binding]; other site
710685001761	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685001762	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
710685001763	intersubunit interface [polypeptide binding]; other site
710685001764	active site
710685001765	Zn2+ binding site [ion binding]; other site
710685001766	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
710685001767	tandem repeat interface [polypeptide binding]; other site
710685001768	oligomer interface [polypeptide binding]; other site
710685001769	active site residues [active]
710685001770	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
710685001771	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
710685001772	tandem repeat interface [polypeptide binding]; other site
710685001773	oligomer interface [polypeptide binding]; other site
710685001774	active site residues [active]
710685001775	Protein of unknown function (DUF732); Region: DUF732; pfam05305
710685001776	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
710685001777	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
710685001778	23S rRNA binding site [nucleotide binding]; other site
710685001779	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
710685001780	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
710685001781	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
710685001782	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
710685001783	5S rRNA interface [nucleotide binding]; other site
710685001784	L27 interface [polypeptide binding]; other site
710685001785	23S rRNA interface [nucleotide binding]; other site
710685001786	L5 interface [polypeptide binding]; other site
710685001787	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
710685001788	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
710685001789	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
710685001790	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
710685001791	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
710685001792	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
710685001793	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
710685001794	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
710685001795	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
710685001796	KOW motif; Region: KOW; cl00354
710685001797	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
710685001798	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
710685001799	beta-lactamase TEM; Provisional; Region: PRK15442
710685001800	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
710685001801	Sulfatase; Region: Sulfatase; cl10460
710685001802	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102
710685001803	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
710685001804	Helix-turn-helix domains; Region: HTH; cl00088
710685001805	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
710685001806	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854
710685001807	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
710685001808	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
710685001809	GAF domain; Region: GAF_2; pfam13185
710685001810	GAF domain; Region: GAF; cl15785
710685001811	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
710685001812	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685001813	Bacterial sugar transferase; Region: Bac_transf; cl00939
710685001814	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
710685001815	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
710685001816	catalytic residue [active]
710685001817	putative FPP diphosphate  binding site; other site
710685001818	putative FPP binding hydrophobic cleft; other site
710685001819	dimer interface [polypeptide binding]; other site
710685001820	putative IPP diphosphate binding site; other site
710685001821	hypothetical protein; Provisional; Region: PRK07208
710685001822	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685001823	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
710685001824	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
710685001825	putative translocon interaction site; other site
710685001826	23S rRNA interface [nucleotide binding]; other site
710685001827	signal recognition particle (SRP54) interaction site; other site
710685001828	L23 interface [polypeptide binding]; other site
710685001829	trigger factor interaction site; other site
710685001830	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
710685001831	23S rRNA interface [nucleotide binding]; other site
710685001832	5S rRNA interface [nucleotide binding]; other site
710685001833	putative antibiotic binding site [chemical binding]; other site
710685001834	L25 interface [polypeptide binding]; other site
710685001835	L27 interface [polypeptide binding]; other site
710685001836	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
710685001837	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
710685001838	G-X-X-G motif; other site
710685001839	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
710685001840	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
710685001841	putative translocon binding site; other site
710685001842	protein-rRNA interface [nucleotide binding]; other site
710685001843	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
710685001844	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
710685001845	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
710685001846	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
710685001847	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
710685001848	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
710685001849	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
710685001850	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
710685001851	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685001852	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685001853	Carboxylesterase family; Region: COesterase; pfam00135
710685001854	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685001855	substrate binding pocket [chemical binding]; other site
710685001856	catalytic triad [active]
710685001857	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685001858	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685001859	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685001860	Helix-turn-helix domains; Region: HTH; cl00088
710685001861	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685001862	putative substrate translocation pore; other site
710685001863	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
710685001864	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
710685001865	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
710685001866	mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965
710685001867	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
710685001868	Probable Catalytic site; other site
710685001869	metal-binding site
710685001870	Creatinine amidohydrolase; Region: Creatininase; cl00618
710685001871	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
710685001872	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
710685001873	phosphate binding site [ion binding]; other site
710685001874	mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962
710685001875	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
710685001876	FeS/SAM binding site; other site
710685001877	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
710685001878	mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967
710685001879	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
710685001880	Helix-turn-helix domains; Region: HTH; cl00088
710685001881	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
710685001882	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685001883	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685001884	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
710685001885	putative dimer interface [polypeptide binding]; other site
710685001886	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685001887	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
710685001888	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
710685001889	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
710685001890	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685001891	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
710685001892	Helix-turn-helix domains; Region: HTH; cl00088
710685001893	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
710685001894	Amidinotransferase; Region: Amidinotransf; cl12043
710685001895	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
710685001896	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
710685001897	inhibitor-cofactor binding pocket; inhibition site
710685001898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685001899	catalytic residue [active]
710685001900	amino acid transporter; Region: 2A0306; TIGR00909
710685001901	Spore germination protein; Region: Spore_permease; cl15802
710685001902	Spore germination protein; Region: Spore_permease; cl15802
710685001903	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685001904	Ligand Binding Site [chemical binding]; other site
710685001905	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685001906	classical (c) SDRs; Region: SDR_c; cd05233
710685001907	NAD(P) binding site [chemical binding]; other site
710685001908	active site
710685001909	Amidinotransferase; Region: Amidinotransf; cl12043
710685001910	arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810
710685001911	Short C-terminal domain; Region: SHOCT; cl01373
710685001912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685001913	putative substrate translocation pore; other site
710685001914	Fungal trichothecene efflux pump (TRI12); Region: TRI12; pfam06609
710685001915	Cutinase; Region: Cutinase; pfam01083
710685001916	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
710685001917	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
710685001918	putative NAD(P) binding site [chemical binding]; other site
710685001919	putative substrate binding site [chemical binding]; other site
710685001920	catalytic Zn binding site [ion binding]; other site
710685001921	structural Zn binding site [ion binding]; other site
710685001922	elongation factor Tu; Reviewed; Region: PRK00049
710685001923	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
710685001924	G1 box; other site
710685001925	GEF interaction site [polypeptide binding]; other site
710685001926	GTP/Mg2+ binding site [chemical binding]; other site
710685001927	Switch I region; other site
710685001928	G2 box; other site
710685001929	G3 box; other site
710685001930	Switch II region; other site
710685001931	G4 box; other site
710685001932	G5 box; other site
710685001933	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
710685001934	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
710685001935	Antibiotic Binding Site [chemical binding]; other site
710685001936	elongation factor G; Reviewed; Region: PRK00007
710685001937	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
710685001938	G1 box; other site
710685001939	putative GEF interaction site [polypeptide binding]; other site
710685001940	GTP/Mg2+ binding site [chemical binding]; other site
710685001941	Switch I region; other site
710685001942	G2 box; other site
710685001943	G3 box; other site
710685001944	Switch II region; other site
710685001945	G4 box; other site
710685001946	G5 box; other site
710685001947	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
710685001948	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
710685001949	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
710685001950	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
710685001951	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
710685001952	S17 interaction site [polypeptide binding]; other site
710685001953	S8 interaction site; other site
710685001954	16S rRNA interaction site [nucleotide binding]; other site
710685001955	streptomycin interaction site [chemical binding]; other site
710685001956	23S rRNA interaction site [nucleotide binding]; other site
710685001957	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
710685001958	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685001959	Helix-turn-helix domains; Region: HTH; cl00088
710685001960	WHG domain; Region: WHG; pfam13305
710685001961	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
710685001962	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
710685001963	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
710685001964	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
710685001965	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685001966	substrate binding site [chemical binding]; other site
710685001967	oxyanion hole (OAH) forming residues; other site
710685001968	trimer interface [polypeptide binding]; other site
710685001969	PaaX-like protein; Region: PaaX; pfam07848
710685001970	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
710685001971	enoyl-CoA hydratase; Provisional; Region: PRK12478
710685001972	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685001973	substrate binding site [chemical binding]; other site
710685001974	oxyanion hole (OAH) forming residues; other site
710685001975	trimer interface [polypeptide binding]; other site
710685001976	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
710685001977	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685001978	active site
710685001979	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
710685001980	active site
710685001981	endonuclease IV; Provisional; Region: PRK01060
710685001982	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
710685001983	AP (apurinic/apyrimidinic) site pocket; other site
710685001984	DNA interaction; other site
710685001985	Metal-binding active site; metal-binding site
710685001986	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
710685001987	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
710685001988	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
710685001989	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
710685001990	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
710685001991	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
710685001992	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
710685001993	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
710685001994	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
710685001995	DNA binding site [nucleotide binding]
710685001996	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
710685001997	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
710685001998	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
710685001999	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
710685002000	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
710685002001	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
710685002002	RPB10 interaction site [polypeptide binding]; other site
710685002003	RPB1 interaction site [polypeptide binding]; other site
710685002004	RPB11 interaction site [polypeptide binding]; other site
710685002005	RPB3 interaction site [polypeptide binding]; other site
710685002006	RPB12 interaction site [polypeptide binding]; other site
710685002007	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
710685002008	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
710685002009	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
710685002010	molybdopterin cofactor binding site; other site
710685002011	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
710685002012	molybdopterin cofactor binding site; other site
710685002013	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
710685002014	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
710685002015	Walker A/P-loop; other site
710685002016	ATP binding site [chemical binding]; other site
710685002017	Q-loop/lid; other site
710685002018	ABC transporter signature motif; other site
710685002019	Walker B; other site
710685002020	D-loop; other site
710685002021	H-loop/switch region; other site
710685002022	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
710685002023	core dimer interface [polypeptide binding]; other site
710685002024	peripheral dimer interface [polypeptide binding]; other site
710685002025	L10 interface [polypeptide binding]; other site
710685002026	L11 interface [polypeptide binding]; other site
710685002027	putative EF-Tu interaction site [polypeptide binding]; other site
710685002028	putative EF-G interaction site [polypeptide binding]; other site
710685002029	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
710685002030	23S rRNA interface [nucleotide binding]; other site
710685002031	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
710685002032	N-acetylmannosamine kinase; Provisional; Region: PRK05082
710685002033	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
710685002034	catalytic site [active]
710685002035	metal binding site [ion binding]; metal-binding site
710685002036	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
710685002037	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
710685002038	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
710685002039	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
710685002040	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
710685002041	putative catalytic site [active]
710685002042	putative metal binding site [ion binding]; other site
710685002043	putative phosphate binding site [ion binding]; other site
710685002044	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
710685002045	putative catalytic site [active]
710685002046	putative phosphate binding site [ion binding]; other site
710685002047	putative metal binding site [ion binding]; other site
710685002048	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
710685002049	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
710685002050	DNA binding residues [nucleotide binding]
710685002051	drug binding residues [chemical binding]; other site
710685002052	dimer interface [polypeptide binding]; other site
710685002053	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
710685002054	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685002055	Predicted transcriptional regulator [Transcription]; Region: COG2378
710685002056	WYL domain; Region: WYL; cl14852
710685002057	DinB superfamily; Region: DinB_2; pfam12867
710685002058	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
710685002059	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685002060	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685002061	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
710685002062	metabolite-proton symporter; Region: 2A0106; TIGR00883
710685002063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685002064	putative substrate translocation pore; other site
710685002065	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
710685002066	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685002067	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
710685002068	active site
710685002069	ATP binding site [chemical binding]; other site
710685002070	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
710685002071	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
710685002072	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685002074	S-adenosylmethionine binding site [chemical binding]; other site
710685002075	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
710685002076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685002077	S-adenosylmethionine binding site [chemical binding]; other site
710685002078	PE-PPE domain; Region: PE-PPE; pfam08237
710685002079	YCII-related domain; Region: YCII; cl00999
710685002080	YCII-related domain; Region: YCII; cl00999
710685002081	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
710685002082	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685002083	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685002084	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002085	TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903
710685002086	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685002087	DNA binding residues [nucleotide binding]
710685002088	dimerization interface [polypeptide binding]; other site
710685002089	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
710685002090	mRNA/rRNA interface [nucleotide binding]; other site
710685002091	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
710685002092	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
710685002093	23S rRNA interface [nucleotide binding]; other site
710685002094	L7/L12 interface [polypeptide binding]; other site
710685002095	putative thiostrepton binding site; other site
710685002096	L25 interface [polypeptide binding]; other site
710685002097	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
710685002098	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
710685002099	putative homodimer interface [polypeptide binding]; other site
710685002100	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
710685002101	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
710685002102	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
710685002103	active site
710685002104	catalytic site [active]
710685002105	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
710685002106	active site
710685002107	catalytic site [active]
710685002108	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
710685002109	LabA_like proteins; Region: LabA_like; cd06167
710685002110	putative metal binding site [ion binding]; other site
710685002111	Uncharacterized conserved protein [Function unknown]; Region: COG1432
710685002112	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
710685002113	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685002114	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
710685002115	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
710685002116	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685002117	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685002118	substrate binding site [chemical binding]; other site
710685002119	oxyanion hole (OAH) forming residues; other site
710685002120	trimer interface [polypeptide binding]; other site
710685002121	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685002122	Helix-turn-helix domains; Region: HTH; cl00088
710685002123	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
710685002124	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
710685002125	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
710685002126	Zn2+ binding site [ion binding]; other site
710685002127	Mg2+ binding site [ion binding]; other site
710685002128	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685002129	DNA binding residues [nucleotide binding]
710685002130	dimerization interface [polypeptide binding]; other site
710685002131	Phospholipid methyltransferase; Region: PEMT; cl00763
710685002132	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
710685002133	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
710685002134	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
710685002135	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685002136	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
710685002137	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
710685002138	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
710685002139	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
710685002140	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
710685002141	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
710685002142	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002143	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
710685002144	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002145	Family description; Region: UvrD_C_2; cl15862
710685002146	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685002147	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
710685002148	putative hydrophobic ligand binding site [chemical binding]; other site
710685002149	protein interface [polypeptide binding]; other site
710685002150	gate; other site
710685002151	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
710685002152	Sulfatase; Region: Sulfatase; cl10460
710685002153	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685002154	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
710685002155	AMP-binding enzyme; Region: AMP-binding; cl15778
710685002156	GAF domain; Region: GAF_2; pfam13185
710685002157	GAF domain; Region: GAF; cl15785
710685002158	ANTAR domain; Region: ANTAR; cl04297
710685002159	GAF domain; Region: GAF; cl15785
710685002160	GAF domain; Region: GAF_2; pfam13185
710685002161	ANTAR domain; Region: ANTAR; cl04297
710685002162	ANTAR domain; Region: ANTAR; cl04297
710685002163	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
710685002164	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
710685002165	putative di-iron ligands [ion binding]; other site
710685002166	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
710685002167	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
710685002168	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
710685002169	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002170	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
710685002171	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
710685002172	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
710685002173	tartrate dehydrogenase; Provisional; Region: PRK08194
710685002174	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
710685002175	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
710685002176	active site
710685002177	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
710685002178	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
710685002179	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
710685002180	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
710685002181	Predicted esterase [General function prediction only]; Region: COG0627
710685002182	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685002183	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
710685002184	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002185	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685002186	RES domain; Region: RES; cl02411
710685002187	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
710685002188	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685002189	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
710685002190	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
710685002191	active site
710685002192	dimer interface [polypeptide binding]; other site
710685002193	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
710685002194	Ligand Binding Site [chemical binding]; other site
710685002195	Molecular Tunnel; other site
710685002196	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
710685002197	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
710685002198	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
710685002199	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
710685002200	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
710685002201	PIF1-like helicase; Region: PIF1; pfam05970
710685002202	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002203	Family description; Region: UvrD_C_2; cl15862
710685002204	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
710685002205	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
710685002206	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
710685002207	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685002208	Helix-turn-helix domains; Region: HTH; cl00088
710685002209	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
710685002210	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
710685002211	Walker A/P-loop; other site
710685002212	ATP binding site [chemical binding]; other site
710685002213	Q-loop/lid; other site
710685002214	ABC transporter signature motif; other site
710685002215	Walker B; other site
710685002216	D-loop; other site
710685002217	H-loop/switch region; other site
710685002218	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
710685002219	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
710685002220	substrate binding pocket [chemical binding]; other site
710685002221	membrane-bound complex binding site; other site
710685002222	hinge residues; other site
710685002223	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
710685002224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685002225	dimer interface [polypeptide binding]; other site
710685002226	conserved gate region; other site
710685002227	putative PBP binding loops; other site
710685002228	ABC-ATPase subunit interface; other site
710685002229	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685002230	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685002231	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685002232	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685002233	YceI-like domain; Region: YceI; cl01001
710685002234	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
710685002235	non-specific DNA binding site [nucleotide binding]; other site
710685002236	salt bridge; other site
710685002237	sequence-specific DNA binding site [nucleotide binding]; other site
710685002238	HipA N-terminal domain; Region: Couple_hipA; cl11853
710685002239	HipA-like N-terminal domain; Region: HipA_N; pfam07805
710685002240	HipA-like C-terminal domain; Region: HipA_C; pfam07804
710685002241	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
710685002242	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
710685002243	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
710685002244	G1 box; other site
710685002245	putative GEF interaction site [polypeptide binding]; other site
710685002246	GTP/Mg2+ binding site [chemical binding]; other site
710685002247	Switch I region; other site
710685002248	G2 box; other site
710685002249	G3 box; other site
710685002250	Switch II region; other site
710685002251	G4 box; other site
710685002252	G5 box; other site
710685002253	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
710685002254	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
710685002255	Helix-turn-helix domains; Region: HTH; cl00088
710685002256	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
710685002257	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
710685002258	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
710685002259	putative NAD(P) binding site [chemical binding]; other site
710685002260	active site
710685002261	thiamine pyrophosphate protein; Provisional; Region: PRK08273
710685002262	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
710685002263	PYR/PP interface [polypeptide binding]; other site
710685002264	dimer interface [polypeptide binding]; other site
710685002265	tetramer interface [polypeptide binding]; other site
710685002266	TPP binding site [chemical binding]; other site
710685002267	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
710685002268	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
710685002269	TPP-binding site [chemical binding]; other site
710685002270	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
710685002271	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
710685002272	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
710685002273	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
710685002274	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
710685002275	metal binding site [ion binding]; metal-binding site
710685002276	substrate binding pocket [chemical binding]; other site
710685002277	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
710685002278	Transposase domain (DUF772); Region: DUF772; cl15789
710685002279	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
710685002280	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
710685002281	PknH-like extracellular domain; Region: PknH_C; pfam14032
710685002282	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
710685002283	oligomeric interface; other site
710685002284	putative active site [active]
710685002285	homodimer interface [polypeptide binding]; other site
710685002286	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
710685002287	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
710685002288	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
710685002289	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
710685002290	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
710685002291	active site
710685002292	catalytic residues [active]
710685002293	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
710685002294	Protein of unknown function (DUF1810); Region: DUF1810; cl02370
710685002295	Restriction endonuclease; Region: Mrr_cat; cl00516
710685002296	ATPase MipZ; Region: MipZ; pfam09140
710685002297	Family description; Region: UvrD_C_2; cl15862
710685002298	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
710685002299	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
710685002300	active site
710685002301	catalytic tetrad [active]
710685002302	Protein of unknown function (DUF732); Region: DUF732; pfam05305
710685002303	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002304	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002305	Walker A/P-loop; other site
710685002306	Walker A/P-loop; other site
710685002307	ATP binding site [chemical binding]; other site
710685002308	ATP binding site [chemical binding]; other site
710685002309	Q-loop/lid; other site
710685002310	ABC transporter signature motif; other site
710685002311	Walker B; other site
710685002312	D-loop; other site
710685002313	AAA domain; Region: AAA_27; pfam13514
710685002314	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
710685002315	ABC transporter signature motif; other site
710685002316	Walker B; other site
710685002317	D-loop; other site
710685002318	H-loop/switch region; other site
710685002319	Uncharacterized conserved protein [Function unknown]; Region: COG4997
710685002320	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685002321	active site
710685002322	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203
710685002323	PLD-like domain; Region: PLDc_2; pfam13091
710685002324	putative homodimer interface [polypeptide binding]; other site
710685002325	putative active site [active]
710685002326	catalytic site [active]
710685002327	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
710685002328	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685002329	nucleotide binding region [chemical binding]; other site
710685002330	ATP-binding site [chemical binding]; other site
710685002331	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
710685002332	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002333	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
710685002334	putative homodimer interface [polypeptide binding]; other site
710685002335	putative active site [active]
710685002336	catalytic site [active]
710685002337	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002338	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002339	Family description; Region: UvrD_C_2; cl15862
710685002340	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
710685002341	putative active site [active]
710685002342	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002343	Restriction endonuclease [Defense mechanisms]; Region: COG3587
710685002344	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002345	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002346	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
710685002347	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002348	Walker A/P-loop; other site
710685002349	ATP binding site [chemical binding]; other site
710685002350	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002351	ABC transporter signature motif; other site
710685002352	Walker B; other site
710685002353	D-loop; other site
710685002354	H-loop/switch region; other site
710685002355	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
710685002356	active site
710685002357	metal binding site [ion binding]; metal-binding site
710685002358	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
710685002359	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002360	Family description; Region: UvrD_C_2; cl15862
710685002361	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
710685002362	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
710685002363	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
710685002364	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
710685002365	anti sigma factor interaction site; other site
710685002366	regulatory phosphorylation site [posttranslational modification]; other site
710685002367	GAF domain; Region: GAF; cl15785
710685002368	GAF domain; Region: GAF; cl15785
710685002369	GAF domain; Region: GAF; cl15785
710685002370	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
710685002371	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
710685002372	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
710685002373	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
710685002374	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
710685002375	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002376	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
710685002377	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
710685002378	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
710685002379	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
710685002380	homodimer interface [polypeptide binding]; other site
710685002381	putative active site [active]
710685002382	DNA repair protein (rad1); Region: rad1; TIGR00596
710685002383	ERCC4 domain; Region: ERCC4; cl10594
710685002384	Lsr2; Region: Lsr2; pfam11774
710685002385	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900
710685002386	SEC-C motif; Region: SEC-C; pfam02810
710685002387	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
710685002388	Cupin superfamily protein; Region: Cupin_4; pfam08007
710685002389	JmjC domain, hydroxylase; Region: JmjC; cl15814
710685002390	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
710685002391	putative dimer interface [polypeptide binding]; other site
710685002392	putative [2Fe-2S] cluster binding site [ion binding]; other site
710685002393	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
710685002394	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685002395	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
710685002396	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
710685002397	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
710685002398	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685002399	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685002400	putative substrate translocation pore; other site
710685002401	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
710685002402	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
710685002403	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148
710685002404	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
710685002405	Coenzyme A binding pocket [chemical binding]; other site
710685002406	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685002407	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
710685002408	Protein of unknown function (DUF3072); Region: DUF3072; pfam11272
710685002409	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
710685002410	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
710685002411	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
710685002412	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
710685002413	hypothetical protein; Provisional; Region: PRK07588
710685002414	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002415	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
710685002416	anti sigma factor interaction site; other site
710685002417	regulatory phosphorylation site [posttranslational modification]; other site
710685002418	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685002419	acyl-CoA synthetase; Provisional; Region: PRK13388
710685002420	AMP-binding enzyme; Region: AMP-binding; cl15778
710685002421	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685002422	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685002423	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685002424	thiolase; Provisional; Region: PRK06158
710685002425	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685002426	active site
710685002427	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685002428	active site 2 [active]
710685002429	active site 1 [active]
710685002430	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
710685002431	active site
710685002432	catalytic site [active]
710685002433	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685002434	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685002435	active site
710685002436	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685002437	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685002438	active site
710685002439	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
710685002440	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685002441	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685002442	Helix-turn-helix domains; Region: HTH; cl00088
710685002443	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
710685002444	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685002445	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685002446	Helix-turn-helix domains; Region: HTH; cl00088
710685002447	WHG domain; Region: WHG; pfam13305
710685002448	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685002449	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685002450	active site
710685002451	ATP binding site [chemical binding]; other site
710685002452	substrate binding site [chemical binding]; other site
710685002453	activation loop (A-loop); other site
710685002454	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
710685002455	ligand binding site [chemical binding]; other site
710685002456	flexible hinge region; other site
710685002457	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685002458	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685002459	active site
710685002460	ATP binding site [chemical binding]; other site
710685002461	substrate binding site [chemical binding]; other site
710685002462	activation loop (A-loop); other site
710685002463	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
710685002464	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002465	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685002466	S-adenosylmethionine binding site [chemical binding]; other site
710685002467	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
710685002468	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685002469	S-adenosylmethionine binding site [chemical binding]; other site
710685002470	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
710685002471	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
710685002472	dimer interface [polypeptide binding]; other site
710685002473	active site
710685002474	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
710685002475	DNA-binding site [nucleotide binding]; DNA binding site
710685002476	RNA-binding motif; other site
710685002477	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
710685002478	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
710685002479	amidase catalytic site [active]
710685002480	Zn binding residues [ion binding]; other site
710685002481	substrate binding site [chemical binding]; other site
710685002482	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
710685002483	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
710685002484	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685002485	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685002486	active site
710685002487	ATP binding site [chemical binding]; other site
710685002488	substrate binding site [chemical binding]; other site
710685002489	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685002490	substrate binding site [chemical binding]; other site
710685002491	activation loop (A-loop); other site
710685002492	activation loop (A-loop); other site
710685002493	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685002494	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685002495	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685002496	active site
710685002497	ATP binding site [chemical binding]; other site
710685002498	substrate binding site [chemical binding]; other site
710685002499	activation loop (A-loop); other site
710685002500	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
710685002501	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
710685002502	substrate binding pocket [chemical binding]; other site
710685002503	membrane-bound complex binding site; other site
710685002504	hinge residues; other site
710685002505	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685002506	Cytochrome P450; Region: p450; pfam00067
710685002507	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
710685002508	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
710685002509	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467
710685002510	acetyl-CoA decarbonylase/synthase complex subunit alpha; Validated; Region: PRK00941
710685002511	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002512	NAD(P) binding site [chemical binding]; other site
710685002513	active site
710685002514	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
710685002515	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685002516	DNA binding residues [nucleotide binding]
710685002517	dimerization interface [polypeptide binding]; other site
710685002518	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
710685002519	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685002520	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685002521	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
710685002522	Spore germination protein; Region: Spore_permease; cl15802
710685002523	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
710685002524	FAD binding domain; Region: FAD_binding_4; pfam01565
710685002525	Berberine and berberine like; Region: BBE; pfam08031
710685002526	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
710685002527	Spore germination protein; Region: Spore_permease; cl15802
710685002528	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
710685002529	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685002530	putative metal binding site [ion binding]; other site
710685002531	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685002532	dimerization interface [polypeptide binding]; other site
710685002533	putative DNA binding site [nucleotide binding]; other site
710685002534	putative Zn2+ binding site [ion binding]; other site
710685002535	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002536	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
710685002537	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
710685002538	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
710685002539	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685002540	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
710685002541	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002542	NAD(P) binding site [chemical binding]; other site
710685002543	active site
710685002544	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
710685002545	Helix-turn-helix domains; Region: HTH; cl00088
710685002546	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685002547	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685002548	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
710685002549	AMP-binding enzyme; Region: AMP-binding; cl15778
710685002550	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685002551	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
710685002552	Sulfatase; Region: Sulfatase; cl10460
710685002553	Protein of unknown function (DUF520); Region: DUF520; cl00723
710685002554	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
710685002555	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
710685002556	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
710685002557	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002558	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
710685002559	Peptidase family M48; Region: Peptidase_M48; cl12018
710685002560	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
710685002561	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
710685002562	substrate binding pocket [chemical binding]; other site
710685002563	chain length determination region; other site
710685002564	substrate-Mg2+ binding site; other site
710685002565	catalytic residues [active]
710685002566	aspartate-rich region 1; other site
710685002567	active site lid residues [active]
710685002568	aspartate-rich region 2; other site
710685002569	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
710685002570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002571	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685002572	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685002573	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
710685002574	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685002575	S-adenosylmethionine binding site [chemical binding]; other site
710685002576	short chain dehydrogenase; Provisional; Region: PRK08263
710685002577	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
710685002578	NADP binding site [chemical binding]; other site
710685002579	active site
710685002580	steroid binding site; other site
710685002581	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
710685002582	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
710685002583	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
710685002584	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
710685002585	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
710685002586	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
710685002587	dimer interface [polypeptide binding]; other site
710685002588	tetramer interface [polypeptide binding]; other site
710685002589	PYR/PP interface [polypeptide binding]; other site
710685002590	TPP binding site [chemical binding]; other site
710685002591	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
710685002592	TPP-binding site; other site
710685002593	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685002594	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685002595	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685002596	Winged helix-turn helix; Region: HTH_29; pfam13551
710685002597	Helix-turn-helix domains; Region: HTH; cl00088
710685002598	Helix-turn-helix domains; Region: HTH; cl00088
710685002599	putative transposase OrfB; Reviewed; Region: PHA02517
710685002600	Integrase core domain; Region: rve; cl01316
710685002601	Integrase core domain; Region: rve_3; cl15866
710685002602	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
710685002603	DJ-1 family protein; Region: not_thiJ; TIGR01383
710685002604	conserved cys residue [active]
710685002605	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
710685002606	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
710685002607	conserved cys residue [active]
710685002608	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685002609	O-succinylbenzoate synthase; Provisional; Region: PRK02901
710685002610	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
710685002611	active site
710685002612	Domain of unknown function (DUF427); Region: DUF427; cl00998
710685002613	TspO/MBR family; Region: TspO_MBR; cl01379
710685002614	SOUL heme-binding protein; Region: SOUL; pfam04832
710685002615	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
710685002616	AMP-binding enzyme; Region: AMP-binding; cl15778
710685002617	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685002618	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685002619	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
710685002620	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
710685002621	active site
710685002622	YCII-related domain; Region: YCII; cl00999
710685002623	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
710685002624	acyl-CoA synthetase; Validated; Region: PRK06188
710685002625	AMP-binding enzyme; Region: AMP-binding; cl15778
710685002626	AMP-binding enzyme; Region: AMP-binding; cl15778
710685002627	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002628	active site
710685002629	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
710685002630	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685002631	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685002632	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685002633	S-adenosylmethionine binding site [chemical binding]; other site
710685002634	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
710685002635	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685002636	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
710685002637	active site
710685002638	HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7
710685002639	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685002640	motif II; other site
710685002641	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685002642	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685002643	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685002644	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
710685002645	substrate binding site [chemical binding]; other site
710685002646	oxyanion hole (OAH) forming residues; other site
710685002647	trimer interface [polypeptide binding]; other site
710685002648	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685002649	short chain dehydrogenase; Provisional; Region: PRK05866
710685002650	classical (c) SDRs; Region: SDR_c; cd05233
710685002651	NAD(P) binding site [chemical binding]; other site
710685002652	active site
710685002653	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
710685002654	AMP-binding enzyme; Region: AMP-binding; cl15778
710685002655	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685002656	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685002657	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
710685002658	active site
710685002659	metal binding site [ion binding]; metal-binding site
710685002660	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
710685002661	Phosphate transporter family; Region: PHO4; cl00396
710685002662	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
710685002663	AMP-binding enzyme; Region: AMP-binding; cl15778
710685002664	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
710685002665	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685002666	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685002667	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685002668	active site
710685002669	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
710685002670	homodimer interface [polypeptide binding]; other site
710685002671	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
710685002672	active site pocket [active]
710685002673	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685002674	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
710685002675	Moco binding site; other site
710685002676	metal coordination site [ion binding]; other site
710685002677	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002678	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
710685002679	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
710685002680	Ligand binding site; other site
710685002681	Putative Catalytic site; other site
710685002682	DXD motif; other site
710685002683	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685002684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685002685	active site
710685002686	phosphorylation site [posttranslational modification]
710685002687	intermolecular recognition site; other site
710685002688	dimerization interface [polypeptide binding]; other site
710685002689	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685002690	DNA binding site [nucleotide binding]
710685002691	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
710685002692	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685002693	dimer interface [polypeptide binding]; other site
710685002694	phosphorylation site [posttranslational modification]
710685002695	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685002696	ATP binding site [chemical binding]; other site
710685002697	Mg2+ binding site [ion binding]; other site
710685002698	G-X-G motif; other site
710685002699	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685002700	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
710685002701	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685002702	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685002703	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
710685002704	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685002705	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
710685002706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002707	NAD(P) binding site [chemical binding]; other site
710685002708	active site
710685002709	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
710685002710	UbiA prenyltransferase family; Region: UbiA; cl00337
710685002711	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685002712	Helix-turn-helix domains; Region: HTH; cl00088
710685002713	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
710685002714	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685002715	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
710685002716	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
710685002717	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
710685002718	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
710685002719	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
710685002720	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
710685002721	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
710685002722	ResB-like family; Region: ResB; pfam05140
710685002723	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
710685002724	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
710685002725	catalytic residues [active]
710685002726	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
710685002727	catalytic core [active]
710685002728	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
710685002729	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
710685002730	inhibitor-cofactor binding pocket; inhibition site
710685002731	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685002732	catalytic residue [active]
710685002733	DivIVA domain; Region: DivI1A_domain; TIGR03544
710685002734	DivIVA domain; Region: DivI1A_domain; TIGR03544
710685002735	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
710685002736	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
710685002737	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
710685002738	structural tetrad; other site
710685002739	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685002740	Cytochrome P450; Region: p450; pfam00067
710685002741	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685002742	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685002743	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685002744	Helix-turn-helix domains; Region: HTH; cl00088
710685002745	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
710685002746	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685002747	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685002748	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
710685002749	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
710685002750	dimer interface [polypeptide binding]; other site
710685002751	active site
710685002752	Schiff base residues; other site
710685002753	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
710685002754	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
710685002755	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
710685002756	active site
710685002757	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
710685002758	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
710685002759	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189
710685002760	domain interfaces; other site
710685002761	active site
710685002762	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
710685002763	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
710685002764	tRNA; other site
710685002765	putative tRNA binding site [nucleotide binding]; other site
710685002766	putative NADP binding site [chemical binding]; other site
710685002767	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
710685002768	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
710685002769	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
710685002770	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685002771	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
710685002772	active site
710685002773	catalytic site [active]
710685002774	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
710685002775	putative acyl-acceptor binding pocket; other site
710685002776	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
710685002777	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
710685002778	putative NAD(P) binding site [chemical binding]; other site
710685002779	active site
710685002780	putative substrate binding site [chemical binding]; other site
710685002781	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
710685002782	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
710685002783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002784	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
710685002785	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685002786	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
710685002787	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
710685002788	AP (apurinic/apyrimidinic) site pocket; other site
710685002789	Metal-binding active site; metal-binding site
710685002790	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
710685002791	YCII-related domain; Region: YCII; cl00999
710685002792	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685002793	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685002794	active site
710685002795	phosphorylation site [posttranslational modification]
710685002796	intermolecular recognition site; other site
710685002797	dimerization interface [polypeptide binding]; other site
710685002798	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685002799	DNA binding site [nucleotide binding]
710685002800	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685002801	dimer interface [polypeptide binding]; other site
710685002802	phosphorylation site [posttranslational modification]
710685002803	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685002804	ATP binding site [chemical binding]; other site
710685002805	Mg2+ binding site [ion binding]; other site
710685002806	G-X-G motif; other site
710685002807	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
710685002808	catalytic core [active]
710685002809	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
710685002810	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
710685002811	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
710685002812	UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449
710685002813	putative ADP-binding pocket [chemical binding]; other site
710685002814	Helix-turn-helix domains; Region: HTH; cl00088
710685002815	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
710685002816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002817	NAD(P) binding site [chemical binding]; other site
710685002818	active site
710685002819	Bacterial Ig-like domain; Region: Big_5; cl01012
710685002820	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
710685002821	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
710685002822	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
710685002823	FAD binding domain; Region: FAD_binding_4; pfam01565
710685002824	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
710685002825	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
710685002826	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685002827	Helix-turn-helix domains; Region: HTH; cl00088
710685002828	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
710685002829	Subunit I/III interface [polypeptide binding]; other site
710685002830	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
710685002831	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685002832	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685002833	Helix-turn-helix domains; Region: HTH; cl00088
710685002834	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685002835	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685002836	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685002837	classical (c) SDRs; Region: SDR_c; cd05233
710685002838	NAD(P) binding site [chemical binding]; other site
710685002839	active site
710685002840	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685002841	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685002842	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
710685002843	NAD binding site [chemical binding]; other site
710685002844	catalytic residues [active]
710685002845	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685002846	mce related protein; Region: MCE; pfam02470
710685002847	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685002848	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685002849	mce related protein; Region: MCE; pfam02470
710685002850	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685002851	mce related protein; Region: MCE; pfam02470
710685002852	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685002853	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685002854	mce related protein; Region: MCE; pfam02470
710685002855	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685002856	mce related protein; Region: MCE; pfam02470
710685002857	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685002858	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685002859	mce related protein; Region: MCE; pfam02470
710685002860	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685002861	thiolase; Provisional; Region: PRK06158
710685002862	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685002863	active site
710685002864	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685002865	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685002866	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685002867	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685002868	Phosphotransferase enzyme family; Region: APH; pfam01636
710685002869	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685002870	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685002871	classical (c) SDRs; Region: SDR_c; cd05233
710685002872	NAD(P) binding site [chemical binding]; other site
710685002873	active site
710685002874	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
710685002875	AMP-binding enzyme; Region: AMP-binding; cl15778
710685002876	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685002877	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002878	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
710685002879	Sodium:solute symporter family; Region: SSF; cl00456
710685002880	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
710685002881	ykkC-yxkD leader
710685002882	Arginase family; Region: Arginase; cl00306
710685002883	Predicted amidohydrolase [General function prediction only]; Region: COG0388
710685002884	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
710685002885	putative active site [active]
710685002886	catalytic triad [active]
710685002887	putative dimer interface [polypeptide binding]; other site
710685002888	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
710685002889	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889
710685002890	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
710685002891	active site
710685002892	catalytic triad [active]
710685002893	calcium binding site [ion binding]; other site
710685002894	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
710685002895	intersubunit interface [polypeptide binding]; other site
710685002896	active site
710685002897	catalytic residue [active]
710685002898	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
710685002899	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
710685002900	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
710685002901	non-specific DNA binding site [nucleotide binding]; other site
710685002902	salt bridge; other site
710685002903	sequence-specific DNA binding site [nucleotide binding]; other site
710685002904	Predicted membrane protein [Function unknown]; Region: COG2733
710685002905	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685002906	Helix-turn-helix domains; Region: HTH; cl00088
710685002907	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
710685002908	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
710685002909	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
710685002910	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002911	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
710685002912	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
710685002913	tetramer interface [polypeptide binding]; other site
710685002914	active site
710685002915	Mg2+/Mn2+ binding site [ion binding]; other site
710685002916	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
710685002917	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
710685002918	active site
710685002919	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685002920	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
710685002921	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
710685002922	non-specific DNA binding site [nucleotide binding]; other site
710685002923	salt bridge; other site
710685002924	sequence-specific DNA binding site [nucleotide binding]; other site
710685002925	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
710685002926	Domain of unknown function (DUF955); Region: DUF955; cl01076
710685002927	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
710685002928	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685002929	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
710685002930	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685002931	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685002932	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
710685002933	Protein of unknown function (DUF779); Region: DUF779; cl01432
710685002934	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
710685002935	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685002936	NAD(P) binding site [chemical binding]; other site
710685002937	catalytic residues [active]
710685002938	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
710685002939	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685002940	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
710685002941	Imelysin; Region: Peptidase_M75; cl09159
710685002942	enoyl-CoA hydratase; Provisional; Region: PRK12478
710685002943	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685002944	substrate binding site [chemical binding]; other site
710685002945	oxyanion hole (OAH) forming residues; other site
710685002946	trimer interface [polypeptide binding]; other site
710685002947	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
710685002948	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
710685002949	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685002950	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
710685002951	NAD(P) binding site [chemical binding]; other site
710685002952	catalytic residues [active]
710685002953	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
710685002954	active site
710685002955	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
710685002956	DinB superfamily; Region: DinB_2; pfam12867
710685002957	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
710685002958	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685002959	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
710685002960	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
710685002961	active site
710685002962	putative substrate binding pocket [chemical binding]; other site
710685002963	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685002964	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685002965	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
710685002966	classical (c) SDRs; Region: SDR_c; cd05233
710685002967	NAD(P) binding site [chemical binding]; other site
710685002968	active site
710685002969	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
710685002970	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
710685002971	putative NAD(P) binding site [chemical binding]; other site
710685002972	dimer interface [polypeptide binding]; other site
710685002973	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
710685002974	putative active site [active]
710685002975	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
710685002976	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
710685002977	ring oligomerisation interface [polypeptide binding]; other site
710685002978	ATP/Mg binding site [chemical binding]; other site
710685002979	stacking interactions; other site
710685002980	hinge regions; other site
710685002981	Helix-turn-helix domains; Region: HTH; cl00088
710685002982	short chain dehydrogenase; Provisional; Region: PRK06197
710685002983	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
710685002984	putative NAD(P) binding site [chemical binding]; other site
710685002985	active site
710685002986	Cupin domain; Region: Cupin_2; cl09118
710685002987	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
710685002988	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685002989	ABC transporter signature motif; other site
710685002990	Walker B; other site
710685002991	D-loop; other site
710685002992	H-loop/switch region; other site
710685002993	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
710685002994	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
710685002995	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
710685002996	ATP binding site [chemical binding]; other site
710685002997	putative Mg++ binding site [ion binding]; other site
710685002998	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
710685002999	Helix-turn-helix domains; Region: HTH; cl00088
710685003000	DNA binding site [nucleotide binding]
710685003001	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685003002	phosphopeptide binding site; other site
710685003003	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
710685003004	putative hydrophobic ligand binding site [chemical binding]; other site
710685003005	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
710685003006	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685003007	active site
710685003008	motif I; other site
710685003009	motif II; other site
710685003010	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685003011	Predicted membrane protein [Function unknown]; Region: COG3428
710685003012	Bacterial PH domain; Region: DUF304; cl01348
710685003013	Bacterial PH domain; Region: DUF304; cl01348
710685003014	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685003015	short chain dehydrogenase; Provisional; Region: PRK06197
710685003016	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
710685003017	putative NAD(P) binding site [chemical binding]; other site
710685003018	active site
710685003019	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
710685003020	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
710685003021	dimer interface [polypeptide binding]; other site
710685003022	putative functional site; other site
710685003023	putative MPT binding site; other site
710685003024	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
710685003025	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
710685003026	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
710685003027	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
710685003028	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
710685003029	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685003030	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685003031	Walker A motif; other site
710685003032	ATP binding site [chemical binding]; other site
710685003033	Walker B motif; other site
710685003034	arginine finger; other site
710685003035	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685003036	S-adenosylmethionine binding site [chemical binding]; other site
710685003037	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
710685003038	2TM domain; Region: 2TM; pfam13239
710685003039	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
710685003040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685003041	active site
710685003042	phosphorylation site [posttranslational modification]
710685003043	intermolecular recognition site; other site
710685003044	dimerization interface [polypeptide binding]; other site
710685003045	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685003046	DNA binding residues [nucleotide binding]
710685003047	dimerization interface [polypeptide binding]; other site
710685003048	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
710685003049	Histidine kinase; Region: HisKA_3; pfam07730
710685003050	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
710685003051	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
710685003052	FOG: CBS domain [General function prediction only]; Region: COG0517
710685003053	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
710685003054	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
710685003055	transmembrane helices; other site
710685003056	hypothetical protein; Provisional; Region: PRK08244
710685003057	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003058	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
710685003059	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
710685003060	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
710685003061	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
710685003062	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
710685003063	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
710685003064	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
710685003065	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
710685003066	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
710685003067	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
710685003068	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
710685003069	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
710685003070	Leucine carboxyl methyltransferase; Region: LCM; cl01306
710685003071	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
710685003072	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
710685003073	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
710685003074	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
710685003075	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
710685003076	E-class dimer interface [polypeptide binding]; other site
710685003077	P-class dimer interface [polypeptide binding]; other site
710685003078	active site
710685003079	Cu2+ binding site [ion binding]; other site
710685003080	Zn2+ binding site [ion binding]; other site
710685003081	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
710685003082	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
710685003083	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
710685003084	active site
710685003085	catalytic residues [active]
710685003086	metal binding site [ion binding]; metal-binding site
710685003087	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685003088	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685003089	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685003090	active site
710685003091	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
710685003092	putative catalytic site [active]
710685003093	putative phosphate binding site [ion binding]; other site
710685003094	active site
710685003095	metal binding site A [ion binding]; metal-binding site
710685003096	DNA binding site [nucleotide binding]
710685003097	putative AP binding site [nucleotide binding]; other site
710685003098	putative metal binding site B [ion binding]; other site
710685003099	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685003100	putative substrate translocation pore; other site
710685003101	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685003102	putative substrate translocation pore; other site
710685003103	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
710685003104	ThiC-associated domain; Region: ThiC-associated; pfam13667
710685003105	ThiC family; Region: ThiC; cl08031
710685003106	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
710685003107	dimer interface [polypeptide binding]; other site
710685003108	substrate binding site [chemical binding]; other site
710685003109	ATP binding site [chemical binding]; other site
710685003110	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
710685003111	Septum formation; Region: Septum_form; pfam13845
710685003112	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685003113	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003114	Predicted membrane protein [Function unknown]; Region: COG4270
710685003115	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685003116	Helix-turn-helix domains; Region: HTH; cl00088
710685003117	Helix-turn-helix domains; Region: HTH; cl00088
710685003118	Spore germination protein; Region: Spore_permease; cl15802
710685003119	amino acid transporter; Region: 2A0306; TIGR00909
710685003120	uracil transporter; Provisional; Region: PRK10720
710685003121	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
710685003122	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
710685003123	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
710685003124	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
710685003125	PA/protease or protease-like domain interface [polypeptide binding]; other site
710685003126	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
710685003127	active site
710685003128	metal binding site [ion binding]; metal-binding site
710685003129	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
710685003130	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
710685003131	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
710685003132	PA/protease or protease-like domain interface [polypeptide binding]; other site
710685003133	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
710685003134	active site
710685003135	metal binding site [ion binding]; metal-binding site
710685003136	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
710685003137	active site
710685003138	catalytic triad [active]
710685003139	oxyanion hole [active]
710685003140	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
710685003141	ThiS interaction site; other site
710685003142	putative active site [active]
710685003143	tetramer interface [polypeptide binding]; other site
710685003144	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
710685003145	thiS-thiF/thiG interaction site; other site
710685003146	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
710685003147	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
710685003148	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
710685003149	thiamine phosphate binding site [chemical binding]; other site
710685003150	active site
710685003151	pyrophosphate binding site [ion binding]; other site
710685003152	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
710685003153	nudix motif; other site
710685003154	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
710685003155	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
710685003156	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
710685003157	substrate binding pocket [chemical binding]; other site
710685003158	membrane-bound complex binding site; other site
710685003159	hinge residues; other site
710685003160	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685003161	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685003162	active site
710685003163	ATP binding site [chemical binding]; other site
710685003164	substrate binding site [chemical binding]; other site
710685003165	activation loop (A-loop); other site
710685003166	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
710685003167	anti sigma factor interaction site; other site
710685003168	regulatory phosphorylation site [posttranslational modification]; other site
710685003169	Acetokinase family; Region: Acetate_kinase; cl01029
710685003170	propionate/acetate kinase; Provisional; Region: PRK12379
710685003171	phosphate acetyltransferase; Reviewed; Region: PRK05632
710685003172	DRTGG domain; Region: DRTGG; cl12147
710685003173	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
710685003174	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
710685003175	putative catalytic site [active]
710685003176	putative metal binding site [ion binding]; other site
710685003177	putative phosphate binding site [ion binding]; other site
710685003178	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003179	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
710685003180	NAD(P) binding site [chemical binding]; other site
710685003181	active site
710685003182	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
710685003183	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
710685003184	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
710685003185	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
710685003186	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
710685003187	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003188	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
710685003189	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
710685003190	active site
710685003191	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
710685003192	MatE; Region: MatE; cl10513
710685003193	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
710685003194	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
710685003195	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685003196	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
710685003197	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685003198	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
710685003199	active site
710685003200	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
710685003201	non-prolyl cis peptide bond; other site
710685003202	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685003203	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
710685003204	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685003205	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
710685003206	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
710685003207	Coenzyme A binding pocket [chemical binding]; other site
710685003208	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
710685003209	classical (c) SDRs; Region: SDR_c; cd05233
710685003210	NAD(P) binding site [chemical binding]; other site
710685003211	active site
710685003212	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685003213	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685003214	active site
710685003215	short chain dehydrogenase; Provisional; Region: PRK07825
710685003216	classical (c) SDRs; Region: SDR_c; cd05233
710685003217	NAD(P) binding site [chemical binding]; other site
710685003218	active site
710685003219	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
710685003220	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
710685003221	homodimer interface [polypeptide binding]; other site
710685003222	substrate-cofactor binding pocket; other site
710685003223	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685003224	catalytic residue [active]
710685003225	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
710685003226	active site residue [active]
710685003227	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
710685003228	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685003229	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957
710685003230	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
710685003231	Helix-turn-helix domains; Region: HTH; cl00088
710685003232	Transport protein; Region: actII; TIGR00833
710685003233	Transport protein; Region: actII; TIGR00833
710685003234	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685003235	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685003236	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685003237	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685003238	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
710685003239	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
710685003240	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685003241	CoenzymeA binding site [chemical binding]; other site
710685003242	subunit interaction site [polypeptide binding]; other site
710685003243	PHB binding site; other site
710685003244	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
710685003245	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
710685003246	GDP-binding site [chemical binding]; other site
710685003247	ACT binding site; other site
710685003248	IMP binding site; other site
710685003249	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
710685003250	active site
710685003251	putative substrate binding region [chemical binding]; other site
710685003252	Cation efflux family; Region: Cation_efflux; cl00316
710685003253	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
710685003254	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
710685003255	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
710685003256	active site
710685003257	intersubunit interface [polypeptide binding]; other site
710685003258	zinc binding site [ion binding]; other site
710685003259	Na+ binding site [ion binding]; other site
710685003260	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
710685003261	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
710685003262	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
710685003263	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
710685003264	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
710685003265	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
710685003266	classical (c) SDRs; Region: SDR_c; cd05233
710685003267	NAD(P) binding site [chemical binding]; other site
710685003268	active site
710685003269	acyl-CoA synthetase; Validated; Region: PRK07788
710685003270	AMP-binding enzyme; Region: AMP-binding; cl15778
710685003271	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685003272	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
710685003273	Clp amino terminal domain; Region: Clp_N; pfam02861
710685003274	Clp amino terminal domain; Region: Clp_N; pfam02861
710685003275	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685003276	Walker A motif; other site
710685003277	ATP binding site [chemical binding]; other site
710685003278	Walker B motif; other site
710685003279	arginine finger; other site
710685003280	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685003281	Walker A motif; other site
710685003282	ATP binding site [chemical binding]; other site
710685003283	Walker B motif; other site
710685003284	arginine finger; other site
710685003285	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
710685003286	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
710685003287	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
710685003288	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
710685003289	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
710685003290	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
710685003291	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
710685003292	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
710685003293	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
710685003294	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
710685003295	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
710685003296	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
710685003297	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685003298	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
710685003299	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685003300	Helix-turn-helix domains; Region: HTH; cl00088
710685003301	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
710685003302	heme-binding site [chemical binding]; other site
710685003303	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
710685003304	FMN reductase; Validated; Region: fre; PRK08051
710685003305	FAD binding pocket [chemical binding]; other site
710685003306	FAD binding motif [chemical binding]; other site
710685003307	phosphate binding motif [ion binding]; other site
710685003308	beta-alpha-beta structure motif; other site
710685003309	NAD binding pocket [chemical binding]; other site
710685003310	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
710685003311	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
710685003312	active site
710685003313	catalytic residues [active]
710685003314	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
710685003315	DNA binding residues [nucleotide binding]
710685003316	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
710685003317	putative dimer interface [polypeptide binding]; other site
710685003318	chaperone protein DnaJ; Provisional; Region: PRK14279
710685003319	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
710685003320	HSP70 interaction site [polypeptide binding]; other site
710685003321	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
710685003322	Zn binding sites [ion binding]; other site
710685003323	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
710685003324	dimer interface [polypeptide binding]; other site
710685003325	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
710685003326	dimer interface [polypeptide binding]; other site
710685003327	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
710685003328	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
710685003329	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
710685003330	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
710685003331	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
710685003332	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
710685003333	TIGR03085 family protein; Region: TIGR03085
710685003334	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
710685003335	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685003336	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685003337	G1 box; other site
710685003338	GTP/Mg2+ binding site [chemical binding]; other site
710685003339	G2 box; other site
710685003340	Switch I region; other site
710685003341	G3 box; other site
710685003342	Switch II region; other site
710685003343	G4 box; other site
710685003344	G5 box; other site
710685003345	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685003346	Dynamin family; Region: Dynamin_N; pfam00350
710685003347	G1 box; other site
710685003348	GTP/Mg2+ binding site [chemical binding]; other site
710685003349	G2 box; other site
710685003350	Switch I region; other site
710685003351	G3 box; other site
710685003352	Switch II region; other site
710685003353	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
710685003354	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685003355	DNA binding residues [nucleotide binding]
710685003356	dimerization interface [polypeptide binding]; other site
710685003357	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
710685003358	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
710685003359	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
710685003360	Cysteine-rich domain; Region: CCG; pfam02754
710685003361	Cysteine-rich domain; Region: CCG; pfam02754
710685003362	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
710685003363	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
710685003364	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685003365	homodimer interface [polypeptide binding]; other site
710685003366	catalytic residue [active]
710685003367	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
710685003368	YibE/F-like protein; Region: YibE_F; cl02259
710685003369	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
710685003370	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
710685003371	substrate binding site; other site
710685003372	tetramer interface; other site
710685003373	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685003374	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
710685003375	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
710685003376	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685003377	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685003378	Helix-turn-helix domains; Region: HTH; cl00088
710685003379	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
710685003380	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003381	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
710685003382	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003383	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
710685003384	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
710685003385	trimer interface [polypeptide binding]; other site
710685003386	active site
710685003387	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
710685003388	active site
710685003389	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
710685003390	dinuclear metal binding motif [ion binding]; other site
710685003391	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
710685003392	Secretory lipase; Region: LIP; pfam03583
710685003393	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
710685003394	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685003395	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685003396	active site
710685003397	ATP binding site [chemical binding]; other site
710685003398	substrate binding site [chemical binding]; other site
710685003399	activation loop (A-loop); other site
710685003400	Uncharacterized conserved protein [Function unknown]; Region: COG3391
710685003401	NHL repeat; Region: NHL; pfam01436
710685003402	NHL repeat; Region: NHL; pfam01436
710685003403	NHL repeat; Region: NHL; pfam01436
710685003404	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
710685003405	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685003406	DNA binding site [nucleotide binding]
710685003407	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685003408	phosphopeptide binding site; other site
710685003409	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
710685003410	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
710685003411	substrate binding pocket [chemical binding]; other site
710685003412	active site
710685003413	iron coordination sites [ion binding]; other site
710685003414	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
710685003415	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
710685003416	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003417	Bacterial sugar transferase; Region: Bac_transf; cl00939
710685003418	GAF domain; Region: GAF; cl15785
710685003419	GAF domain; Region: GAF_2; pfam13185
710685003420	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
710685003421	anti sigma factor interaction site; other site
710685003422	regulatory phosphorylation site [posttranslational modification]; other site
710685003423	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
710685003424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
710685003425	MASE1; Region: MASE1; pfam05231
710685003426	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
710685003427	Domain of unknown function (DUF427); Region: DUF427; cl00998
710685003428	Domain of unknown function (DUF427); Region: DUF427; cl00998
710685003429	Interferon-induced transmembrane protein; Region: CD225; pfam04505
710685003430	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
710685003431	pyranose oxidase; Region: pyranose_ox; TIGR02462
710685003432	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
710685003433	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685003434	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685003435	active site
710685003436	ATP binding site [chemical binding]; other site
710685003437	substrate binding site [chemical binding]; other site
710685003438	activation loop (A-loop); other site
710685003439	Transport protein; Region: actII; TIGR00833
710685003440	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
710685003441	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003442	NAD(P) binding site [chemical binding]; other site
710685003443	active site
710685003444	Transcriptional regulators [Transcription]; Region: FadR; COG2186
710685003445	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685003446	DNA-binding site [nucleotide binding]; DNA binding site
710685003447	FCD domain; Region: FCD; cl11656
710685003448	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
710685003449	AMP-binding enzyme; Region: AMP-binding; cl15778
710685003450	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
710685003451	intersubunit interface [polypeptide binding]; other site
710685003452	active site
710685003453	Zn2+ binding site [ion binding]; other site
710685003454	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685003455	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
710685003456	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685003457	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
710685003458	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
710685003459	active site
710685003460	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
710685003461	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
710685003462	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
710685003463	active site
710685003464	Eukaryotic porin family that forms channels in the mitochondrial outer membrane; Region: Porin3; cl03224
710685003465	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685003466	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685003467	active site
710685003468	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
710685003469	Sulfatase; Region: Sulfatase; cl10460
710685003470	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
710685003471	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
710685003472	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
710685003473	Active Sites [active]
710685003474	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
710685003475	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
710685003476	CysD dimerization site [polypeptide binding]; other site
710685003477	G1 box; other site
710685003478	putative GEF interaction site [polypeptide binding]; other site
710685003479	GTP/Mg2+ binding site [chemical binding]; other site
710685003480	Switch I region; other site
710685003481	G2 box; other site
710685003482	G3 box; other site
710685003483	Switch II region; other site
710685003484	G4 box; other site
710685003485	G5 box; other site
710685003486	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
710685003487	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
710685003488	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
710685003489	ligand-binding site [chemical binding]; other site
710685003490	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
710685003491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685003492	S-adenosylmethionine binding site [chemical binding]; other site
710685003493	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685003494	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685003495	Protein of unknown function (DUF2984); Region: DUF2984; cl12752
710685003496	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
710685003497	active site
710685003498	catalytic residues [active]
710685003499	Ubiquitin-like proteins; Region: UBQ; cl00155
710685003500	EspG family; Region: ESX-1_EspG; pfam14011
710685003501	Proteins of 100 residues with WXG; Region: WXG100; cl02005
710685003502	PPE family; Region: PPE; pfam00823
710685003503	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
710685003504	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685003505	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
710685003506	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685003507	Protein of unknown function (DUF690); Region: DUF690; cl04939
710685003508	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
710685003509	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685003510	Walker A motif; other site
710685003511	ATP binding site [chemical binding]; other site
710685003512	Walker B motif; other site
710685003513	arginine finger; other site
710685003514	Leucine carboxyl methyltransferase; Region: LCM; cl01306
710685003515	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685003516	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685003517	cyclase homology domain; Region: CHD; cd07302
710685003518	nucleotidyl binding site; other site
710685003519	metal binding site [ion binding]; metal-binding site
710685003520	dimer interface [polypeptide binding]; other site
710685003521	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
710685003522	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
710685003523	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685003524	Zn binding site [ion binding]; other site
710685003525	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685003526	Helix-turn-helix domains; Region: HTH; cl00088
710685003527	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685003528	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
710685003529	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
710685003530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003531	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685003532	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685003533	active site
710685003534	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685003535	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
710685003536	FAD binding site [chemical binding]; other site
710685003537	substrate binding site [chemical binding]; other site
710685003538	catalytic base [active]
710685003539	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685003540	classical (c) SDRs; Region: SDR_c; cd05233
710685003541	NAD(P) binding site [chemical binding]; other site
710685003542	active site
710685003543	acyl-CoA synthetase; Validated; Region: PRK07788
710685003544	AMP-binding enzyme; Region: AMP-binding; cl15778
710685003545	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685003546	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
710685003547	nucleotide binding site [chemical binding]; other site
710685003548	YacP-like NYN domain; Region: NYN_YacP; cl01491
710685003549	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
710685003550	salt bridge; other site
710685003551	non-specific DNA binding site [nucleotide binding]; other site
710685003552	sequence-specific DNA binding site [nucleotide binding]; other site
710685003553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003554	NAD(P) binding site [chemical binding]; other site
710685003555	active site
710685003556	TIGR03086 family protein; Region: TIGR03086
710685003557	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
710685003558	Helix-turn-helix domains; Region: HTH; cl00088
710685003559	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
710685003560	Protein of unknown function (DUF808); Region: DUF808; cl01002
710685003561	hypothetical protein; Provisional; Region: PRK06753
710685003562	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003563	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
710685003564	Helix-turn-helix domains; Region: HTH; cl00088
710685003565	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685003566	dimerization interface [polypeptide binding]; other site
710685003567	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
710685003568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685003569	putative substrate translocation pore; other site
710685003570	LysE type translocator; Region: LysE; cl00565
710685003571	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
710685003572	Helix-turn-helix domains; Region: HTH; cl00088
710685003573	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
710685003574	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003575	NAD(P) binding site [chemical binding]; other site
710685003576	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
710685003577	active site
710685003578	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
710685003579	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
710685003580	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
710685003581	intersubunit interface [polypeptide binding]; other site
710685003582	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
710685003583	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
710685003584	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
710685003585	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
710685003586	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685003587	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
710685003588	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
710685003589	active site
710685003590	Helix-turn-helix domains; Region: HTH; cl00088
710685003591	DNA binding site [nucleotide binding]
710685003592	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
710685003593	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
710685003594	putative active site [active]
710685003595	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
710685003596	putative active site [active]
710685003597	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891
710685003598	E-class dimer interface [polypeptide binding]; other site
710685003599	P-class dimer interface [polypeptide binding]; other site
710685003600	active site
710685003601	Cu2+ binding site [ion binding]; other site
710685003602	Zn2+ binding site [ion binding]; other site
710685003603	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
710685003604	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
710685003605	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685003606	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
710685003607	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
710685003608	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
710685003609	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
710685003610	putative dimer interface [polypeptide binding]; other site
710685003611	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
710685003612	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
710685003613	tetramer interface [polypeptide binding]; other site
710685003614	active site
710685003615	Mg2+/Mn2+ binding site [ion binding]; other site
710685003616	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
710685003617	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003618	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
710685003619	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
710685003620	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
710685003621	Flavin Reductases; Region: FlaRed; cl00801
710685003622	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685003623	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003624	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
710685003625	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
710685003626	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
710685003627	FAD binding site [chemical binding]; other site
710685003628	substrate binding site [chemical binding]; other site
710685003629	catalytic residues [active]
710685003630	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
710685003631	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685003632	dimer interface [polypeptide binding]; other site
710685003633	phosphorylation site [posttranslational modification]
710685003634	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685003635	ATP binding site [chemical binding]; other site
710685003636	Mg2+ binding site [ion binding]; other site
710685003637	G-X-G motif; other site
710685003638	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685003639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685003640	active site
710685003641	phosphorylation site [posttranslational modification]
710685003642	intermolecular recognition site; other site
710685003643	dimerization interface [polypeptide binding]; other site
710685003644	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685003645	DNA binding site [nucleotide binding]
710685003646	Sulfate transporter family; Region: Sulfate_transp; cl15842
710685003647	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
710685003648	active site clefts [active]
710685003649	zinc binding site [ion binding]; other site
710685003650	dimer interface [polypeptide binding]; other site
710685003651	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685003652	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
710685003653	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
710685003654	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
710685003655	gating phenylalanine in ion channel; other site
710685003656	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
710685003657	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
710685003658	dimer interface [polypeptide binding]; other site
710685003659	active site
710685003660	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
710685003661	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003662	active site
710685003663	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003664	NAD(P) binding site [chemical binding]; other site
710685003665	active site
710685003666	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685003667	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685003668	active site 2 [active]
710685003669	active site 1 [active]
710685003670	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
710685003671	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
710685003672	homodimer interface [polypeptide binding]; other site
710685003673	active site
710685003674	TDP-binding site; other site
710685003675	acceptor substrate-binding pocket; other site
710685003676	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
710685003677	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
710685003678	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685003679	Walker A/P-loop; other site
710685003680	ATP binding site [chemical binding]; other site
710685003681	Q-loop/lid; other site
710685003682	ABC transporter signature motif; other site
710685003683	Walker B; other site
710685003684	D-loop; other site
710685003685	H-loop/switch region; other site
710685003686	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
710685003687	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
710685003688	active site
710685003689	zinc binding site [ion binding]; other site
710685003690	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685003691	Helix-turn-helix domains; Region: HTH; cl00088
710685003692	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
710685003693	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
710685003694	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
710685003695	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
710685003696	active site
710685003697	substrate binding pocket [chemical binding]; other site
710685003698	homodimer interaction site [polypeptide binding]; other site
710685003699	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
710685003700	AMP-binding enzyme; Region: AMP-binding; cl15778
710685003701	OpgC protein; Region: OpgC_C; cl00792
710685003702	Acyltransferase family; Region: Acyl_transf_3; pfam01757
710685003703	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
710685003704	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
710685003705	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
710685003706	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685003707	S-adenosylmethionine binding site [chemical binding]; other site
710685003708	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
710685003709	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685003710	NAD binding site [chemical binding]; other site
710685003711	catalytic residues [active]
710685003712	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685003713	Helix-turn-helix domains; Region: HTH; cl00088
710685003714	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
710685003715	Helix-turn-helix domain; Region: HTH_18; pfam12833
710685003716	DinB superfamily; Region: DinB_2; pfam12867
710685003717	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685003718	active site
710685003719	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685003720	active site
710685003721	N-acetyltransferase; Region: Acetyltransf_2; cl00949
710685003722	enoyl-CoA hydratase; Provisional; Region: PRK08252
710685003723	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685003724	substrate binding site [chemical binding]; other site
710685003725	oxyanion hole (OAH) forming residues; other site
710685003726	trimer interface [polypeptide binding]; other site
710685003727	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685003728	active site
710685003729	ATP binding site [chemical binding]; other site
710685003730	substrate binding site [chemical binding]; other site
710685003731	activation loop (A-loop); other site
710685003732	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
710685003733	putative acyl-acceptor binding pocket; other site
710685003734	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685003735	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
710685003736	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685003737	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685003738	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
710685003739	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685003740	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685003741	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685003742	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685003743	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685003744	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685003745	active site
710685003746	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685003747	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685003748	active site
710685003749	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685003750	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685003751	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
710685003752	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685003753	active site
710685003754	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685003755	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685003756	active site 2 [active]
710685003757	active site 1 [active]
710685003758	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685003759	active site 2 [active]
710685003760	active site 1 [active]
710685003761	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685003762	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685003763	active site
710685003764	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
710685003765	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685003766	DNA-binding site [nucleotide binding]; DNA binding site
710685003767	UTRA domain; Region: UTRA; cl01230
710685003768	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685003769	substrate binding site [chemical binding]; other site
710685003770	oxyanion hole (OAH) forming residues; other site
710685003771	trimer interface [polypeptide binding]; other site
710685003772	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
710685003773	AMP-binding enzyme; Region: AMP-binding; cl15778
710685003774	AMP-binding enzyme; Region: AMP-binding; cl15778
710685003775	cyclase homology domain; Region: CHD; cd07302
710685003776	nucleotidyl binding site; other site
710685003777	metal binding site [ion binding]; metal-binding site
710685003778	dimer interface [polypeptide binding]; other site
710685003779	Predicted ATPase [General function prediction only]; Region: COG3903
710685003780	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
710685003781	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
710685003782	active site
710685003783	substrate-binding site [chemical binding]; other site
710685003784	metal-binding site [ion binding]
710685003785	GTP binding site [chemical binding]; other site
710685003786	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685003787	S-adenosylmethionine binding site [chemical binding]; other site
710685003788	LabA_like proteins; Region: LabA_like; cd06167
710685003789	putative metal binding site [ion binding]; other site
710685003790	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
710685003791	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
710685003792	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
710685003793	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
710685003794	Predicted integral membrane protein [Function unknown]; Region: COG0392
710685003795	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
710685003796	Peptidase family M23; Region: Peptidase_M23; pfam01551
710685003797	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
710685003798	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
710685003799	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685003800	phosphorylation site [posttranslational modification]
710685003801	dimer interface [polypeptide binding]; other site
710685003802	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685003803	ATP binding site [chemical binding]; other site
710685003804	Mg2+ binding site [ion binding]; other site
710685003805	G-X-G motif; other site
710685003806	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685003807	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685003808	active site
710685003809	phosphorylation site [posttranslational modification]
710685003810	intermolecular recognition site; other site
710685003811	dimerization interface [polypeptide binding]; other site
710685003812	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685003813	DNA binding site [nucleotide binding]
710685003814	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
710685003815	Protein export membrane protein; Region: SecD_SecF; cl14618
710685003816	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
710685003817	non-specific DNA binding site [nucleotide binding]; other site
710685003818	salt bridge; other site
710685003819	sequence-specific DNA binding site [nucleotide binding]; other site
710685003820	DsrE/DsrF-like family; Region: DrsE; cl00672
710685003821	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003822	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
710685003823	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
710685003824	active site
710685003825	Zn binding site [ion binding]; other site
710685003826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
710685003827	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
710685003828	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
710685003829	putative homotetramer interface [polypeptide binding]; other site
710685003830	putative homodimer interface [polypeptide binding]; other site
710685003831	putative allosteric switch controlling residues; other site
710685003832	putative metal binding site [ion binding]; other site
710685003833	putative homodimer-homodimer interface [polypeptide binding]; other site
710685003834	Domain of unknown function (DUF305); Region: DUF305; cl15795
710685003835	Dehydratase family; Region: ILVD_EDD; cl00340
710685003836	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685003837	hydrophobic ligand binding site; other site
710685003838	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
710685003839	FAD binding domain; Region: FAD_binding_4; pfam01565
710685003840	transcriptional repressor IclR; Provisional; Region: PRK11569
710685003841	Bacterial transcriptional regulator; Region: IclR; pfam01614
710685003842	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685003843	S-adenosylmethionine binding site [chemical binding]; other site
710685003844	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
710685003845	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
710685003846	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685003847	RNA polymerase factor sigma-70; Validated; Region: PRK08241
710685003848	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685003849	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685003850	DNA binding residues [nucleotide binding]
710685003851	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685003852	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
710685003853	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
710685003854	Helix-turn-helix domains; Region: HTH; cl00088
710685003855	Pirin-related protein [General function prediction only]; Region: COG1741
710685003856	Cupin domain; Region: Cupin_2; cl09118
710685003857	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
710685003858	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
710685003859	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685003860	hydrophobic ligand binding site; other site
710685003861	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
710685003862	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685003863	short chain dehydrogenase; Provisional; Region: PRK06914
710685003864	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003865	NAD(P) binding site [chemical binding]; other site
710685003866	active site
710685003867	Protein of unknown function (DUF732); Region: DUF732; pfam05305
710685003868	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
710685003869	RDD family; Region: RDD; cl00746
710685003870	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685003871	mce related protein; Region: MCE; pfam02470
710685003872	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685003873	mce related protein; Region: MCE; pfam02470
710685003874	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685003875	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685003876	mce related protein; Region: MCE; pfam02470
710685003877	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685003878	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685003879	mce related protein; Region: MCE; pfam02470
710685003880	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685003881	mce related protein; Region: MCE; pfam02470
710685003882	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685003883	mce related protein; Region: MCE; pfam02470
710685003884	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685003885	Permease; Region: Permease; cl00510
710685003886	Permease; Region: Permease; cl00510
710685003887	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
710685003888	AMP-binding enzyme; Region: AMP-binding; cl15778
710685003889	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685003890	Transcriptional regulators [Transcription]; Region: GntR; COG1802
710685003891	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685003892	DNA-binding site [nucleotide binding]; DNA binding site
710685003893	FCD domain; Region: FCD; cl11656
710685003894	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
710685003895	putative hydrophobic ligand binding site [chemical binding]; other site
710685003896	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
710685003897	active site
710685003898	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003899	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685003900	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685003901	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685003902	DNA binding residues [nucleotide binding]
710685003903	dimerization interface [polypeptide binding]; other site
710685003904	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
710685003905	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003906	NAD(P) binding site [chemical binding]; other site
710685003907	Mechanosensitive ion channel; Region: MS_channel; pfam00924
710685003908	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
710685003909	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
710685003910	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685003911	active site
710685003912	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
710685003913	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685003914	Helix-turn-helix domains; Region: HTH; cl00088
710685003915	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
710685003916	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
710685003917	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685003918	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
710685003919	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
710685003920	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
710685003921	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685003922	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685003923	active site
710685003924	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685003925	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685003926	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
710685003927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685003928	ATP binding site [chemical binding]; other site
710685003929	Mg2+ binding site [ion binding]; other site
710685003930	G-X-G motif; other site
710685003931	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
710685003932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685003933	active site
710685003934	phosphorylation site [posttranslational modification]
710685003935	intermolecular recognition site; other site
710685003936	dimerization interface [polypeptide binding]; other site
710685003937	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685003938	DNA binding residues [nucleotide binding]
710685003939	dimerization interface [polypeptide binding]; other site
710685003940	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
710685003941	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685003942	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685003943	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685003944	active site
710685003945	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
710685003946	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
710685003947	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
710685003948	Protein of unknown function (DUF456); Region: DUF456; cl01069
710685003949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685003950	S-adenosylmethionine binding site [chemical binding]; other site
710685003951	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
710685003952	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685003953	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
710685003954	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
710685003955	NAD(P) binding site [chemical binding]; other site
710685003956	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
710685003957	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
710685003958	homodimer interface [polypeptide binding]; other site
710685003959	NAD binding site [chemical binding]; other site
710685003960	active site
710685003961	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
710685003962	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
710685003963	NAD(P) binding site [chemical binding]; other site
710685003964	catalytic residues [active]
710685003965	Leucine carboxyl methyltransferase; Region: LCM; cl01306
710685003966	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685003967	Helix-turn-helix domains; Region: HTH; cl00088
710685003968	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685003969	Helix-turn-helix domains; Region: HTH; cl00088
710685003970	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
710685003971	Pirin-related protein [General function prediction only]; Region: COG1741
710685003972	Cupin domain; Region: Cupin_2; cl09118
710685003973	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
710685003974	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
710685003975	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
710685003976	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
710685003977	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
710685003978	Helix-turn-helix domains; Region: HTH; cl00088
710685003979	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
710685003980	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
710685003981	putative substrate binding site [chemical binding]; other site
710685003982	putative ATP binding site [chemical binding]; other site
710685003983	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
710685003984	active site
710685003985	phosphorylation site [posttranslational modification]
710685003986	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
710685003987	active site
710685003988	P-loop; other site
710685003989	phosphorylation site [posttranslational modification]
710685003990	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
710685003991	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
710685003992	dimerization domain swap beta strand [polypeptide binding]; other site
710685003993	regulatory protein interface [polypeptide binding]; other site
710685003994	active site
710685003995	regulatory phosphorylation site [posttranslational modification]; other site
710685003996	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
710685003997	active site
710685003998	catalytic residues [active]
710685003999	Protein of unknown function (DUF2984); Region: DUF2984; cl12752
710685004000	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
710685004001	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
710685004002	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685004003	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
710685004004	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
710685004005	active site
710685004006	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685004007	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
710685004008	Walker A/P-loop; other site
710685004009	ATP binding site [chemical binding]; other site
710685004010	Q-loop/lid; other site
710685004011	ABC transporter signature motif; other site
710685004012	Walker B; other site
710685004013	D-loop; other site
710685004014	H-loop/switch region; other site
710685004015	TOBE domain; Region: TOBE_2; cl01440
710685004016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685004017	dimer interface [polypeptide binding]; other site
710685004018	conserved gate region; other site
710685004019	putative PBP binding loops; other site
710685004020	ABC-ATPase subunit interface; other site
710685004021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
710685004022	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
710685004023	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685004024	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685004025	Helix-turn-helix domains; Region: HTH; cl00088
710685004026	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685004027	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
710685004028	elongation factor G; Reviewed; Region: PRK12740
710685004029	G1 box; other site
710685004030	putative GEF interaction site [polypeptide binding]; other site
710685004031	GTP/Mg2+ binding site [chemical binding]; other site
710685004032	Switch I region; other site
710685004033	G2 box; other site
710685004034	G3 box; other site
710685004035	Switch II region; other site
710685004036	G4 box; other site
710685004037	G5 box; other site
710685004038	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
710685004039	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
710685004040	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
710685004041	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
710685004042	putative active site [active]
710685004043	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685004044	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
710685004045	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889
710685004046	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
710685004047	active site
710685004048	catalytic triad [active]
710685004049	calcium binding site [ion binding]; other site
710685004050	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
710685004051	anti sigma factor interaction site; other site
710685004052	regulatory phosphorylation site [posttranslational modification]; other site
710685004053	Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
710685004054	Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
710685004055	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
710685004056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
710685004057	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
710685004058	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
710685004059	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
710685004060	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
710685004061	PAS domain; Region: PAS_9; pfam13426
710685004062	putative active site [active]
710685004063	heme pocket [chemical binding]; other site
710685004064	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
710685004065	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
710685004066	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
710685004067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
710685004068	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685004069	Helix-turn-helix domains; Region: HTH; cl00088
710685004070	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685004071	metabolite-proton symporter; Region: 2A0106; TIGR00883
710685004072	putative substrate translocation pore; other site
710685004073	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
710685004074	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685004075	MoxR-like ATPases [General function prediction only]; Region: COG0714
710685004076	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685004077	Walker A motif; other site
710685004078	ATP binding site [chemical binding]; other site
710685004079	Walker B motif; other site
710685004080	arginine finger; other site
710685004081	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
710685004082	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685004083	S-adenosylmethionine binding site [chemical binding]; other site
710685004084	K+ potassium transporter; Region: K_trans; cl15781
710685004085	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685004086	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685004087	active site
710685004088	GtrA-like protein; Region: GtrA; cl00971
710685004089	Rhomboid family; Region: Rhomboid; cl11446
710685004090	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
710685004091	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
710685004092	FMN binding site [chemical binding]; other site
710685004093	dimer interface [polypeptide binding]; other site
710685004094	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
710685004095	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685004096	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
710685004097	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
710685004098	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
710685004099	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685004100	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
710685004101	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
710685004102	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
710685004103	ATP binding site [chemical binding]; other site
710685004104	putative Mg++ binding site [ion binding]; other site
710685004105	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685004106	nucleotide binding region [chemical binding]; other site
710685004107	Helicase associated domain (HA2); Region: HA2; cl04503
710685004108	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
710685004109	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
710685004110	Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428
710685004111	Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696
710685004112	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685004113	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685004114	Uncharacterized conserved protein [Function unknown]; Region: COG2128
710685004115	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685004116	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
710685004117	putative FMN binding site [chemical binding]; other site
710685004118	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004119	NADH(P)-binding; Region: NAD_binding_10; pfam13460
710685004120	NAD(P) binding site [chemical binding]; other site
710685004121	active site
710685004122	Helix-turn-helix domains; Region: HTH; cl00088
710685004123	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
710685004124	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
710685004125	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
710685004126	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
710685004127	putative active site [active]
710685004128	putative metal binding site [ion binding]; other site
710685004129	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
710685004130	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685004131	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
710685004132	Family description; Region: UvrD_C_2; cl15862
710685004133	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
710685004134	putative active site [active]
710685004135	putative CoA binding site [chemical binding]; other site
710685004136	nudix motif; other site
710685004137	metal binding site [ion binding]; metal-binding site
710685004138	Transcriptional regulators [Transcription]; Region: MarR; COG1846
710685004139	Helix-turn-helix domains; Region: HTH; cl00088
710685004140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685004141	putative substrate translocation pore; other site
710685004142	Major Facilitator Superfamily; Region: MFS_1; pfam07690
710685004143	Leucine carboxyl methyltransferase; Region: LCM; cl01306
710685004144	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
710685004145	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
710685004146	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685004147	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685004148	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
710685004149	active site
710685004150	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685004151	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685004152	active site
710685004153	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685004154	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685004155	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685004156	Transcriptional regulator [Transcription]; Region: LysR; COG0583
710685004157	Helix-turn-helix domains; Region: HTH; cl00088
710685004158	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685004159	dimerization interface [polypeptide binding]; other site
710685004160	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685004161	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
710685004162	ATP binding site [chemical binding]; other site
710685004163	putative Mg++ binding site [ion binding]; other site
710685004164	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685004165	nucleotide binding region [chemical binding]; other site
710685004166	ATP-binding site [chemical binding]; other site
710685004167	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
710685004168	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685004169	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685004170	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685004171	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685004172	active site
710685004173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685004174	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
710685004175	putative substrate translocation pore; other site
710685004176	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
710685004177	active site
710685004178	catalytic residues [active]
710685004179	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
710685004180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685004181	S-adenosylmethionine binding site [chemical binding]; other site
710685004182	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
710685004183	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685004184	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
710685004185	classical (c) SDRs; Region: SDR_c; cd05233
710685004186	NAD(P) binding site [chemical binding]; other site
710685004187	active site
710685004188	FAD binding domain; Region: FAD_binding_4; pfam01565
710685004189	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
710685004190	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
710685004191	macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450
710685004192	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
710685004193	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
710685004194	benzoylformate decarboxylase; Reviewed; Region: PRK07092
710685004195	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
710685004196	PYR/PP interface [polypeptide binding]; other site
710685004197	dimer interface [polypeptide binding]; other site
710685004198	TPP binding site [chemical binding]; other site
710685004199	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
710685004200	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
710685004201	TPP-binding site [chemical binding]; other site
710685004202	dimer interface [polypeptide binding]; other site
710685004203	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685004204	Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263
710685004205	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
710685004206	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685004207	MoxR-like ATPases [General function prediction only]; Region: COG0714
710685004208	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685004209	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685004210	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
710685004211	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
710685004212	active site
710685004213	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
710685004214	catalytic triad [active]
710685004215	dimer interface [polypeptide binding]; other site
710685004216	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
710685004217	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
710685004218	putative active site [active]
710685004219	putative metal binding site [ion binding]; other site
710685004220	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315
710685004221	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
710685004222	Amidase; Region: Amidase; cl11426
710685004223	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685004224	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685004225	substrate binding site [chemical binding]; other site
710685004226	oxyanion hole (OAH) forming residues; other site
710685004227	trimer interface [polypeptide binding]; other site
710685004228	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
710685004229	AMP-binding enzyme; Region: AMP-binding; cl15778
710685004230	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
710685004231	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
710685004232	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
710685004233	active site
710685004234	catalytic site [active]
710685004235	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
710685004236	active site
710685004237	catalytic site [active]
710685004238	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004239	short chain dehydrogenase; Provisional; Region: PRK06841
710685004240	NAD(P) binding site [chemical binding]; other site
710685004241	active site
710685004242	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
710685004243	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685004244	catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438
710685004245	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
710685004246	active site
710685004247	Muconolactone delta-isomerase; Region: MIase; cl01992
710685004248	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
710685004249	Transcriptional regulator [Transcription]; Region: LysR; COG0583
710685004250	Helix-turn-helix domains; Region: HTH; cl00088
710685004251	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
710685004252	classical (c) SDRs; Region: SDR_c; cd05233
710685004253	NAD(P) binding site [chemical binding]; other site
710685004254	active site
710685004255	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685004256	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
710685004257	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685004258	TIGR03085 family protein; Region: TIGR03085
710685004259	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
710685004260	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
710685004261	putative active site [active]
710685004262	putative active site [active]
710685004263	catalytic site [active]
710685004264	catalytic site [active]
710685004265	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
710685004266	phospholipase D epsilon; Region: PLN02352
710685004267	putative active site [active]
710685004268	catalytic site [active]
710685004269	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
710685004270	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004271	Isochorismatase family; Region: Isochorismatase; pfam00857
710685004272	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
710685004273	catalytic triad [active]
710685004274	conserved cis-peptide bond; other site
710685004275	oxidoreductase; Provisional; Region: PRK06196
710685004276	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004277	NAD(P) binding site [chemical binding]; other site
710685004278	active site
710685004279	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
710685004280	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004281	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
710685004282	Helix-turn-helix domains; Region: HTH; cl00088
710685004283	WHG domain; Region: WHG; pfam13305
710685004284	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
710685004285	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292
710685004286	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
710685004287	active site
710685004288	Protein of unknown function, DUF488; Region: DUF488; cl01246
710685004289	Phospholipid methyltransferase; Region: PEMT; cl00763
710685004290	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004291	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
710685004292	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
710685004293	putative heme binding pocket [chemical binding]; other site
710685004294	replicative DNA helicase; Validated; Region: PRK07773
710685004295	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
710685004296	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
710685004297	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685004298	Walker A motif; other site
710685004299	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
710685004300	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
710685004301	ATP binding site [chemical binding]; other site
710685004302	Walker B motif; other site
710685004303	DNA binding loops [nucleotide binding]
710685004304	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
710685004305	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
710685004306	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
710685004307	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
710685004308	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
710685004309	dimer interface [polypeptide binding]; other site
710685004310	ssDNA binding site [nucleotide binding]; other site
710685004311	tetramer (dimer of dimers) interface [polypeptide binding]; other site
710685004312	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
710685004313	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685004314	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
710685004315	cyclase homology domain; Region: CHD; cd07302
710685004316	nucleotidyl binding site; other site
710685004317	metal binding site [ion binding]; metal-binding site
710685004318	dimer interface [polypeptide binding]; other site
710685004319	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
710685004320	active site
710685004321	catalytic triad [active]
710685004322	oxyanion hole [active]
710685004323	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
710685004324	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
710685004325	Transglycosylase; Region: Transgly; cl07896
710685004326	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685004327	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
710685004328	Helix-turn-helix domains; Region: HTH; cl00088
710685004329	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
710685004330	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685004331	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685004332	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
710685004333	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
710685004334	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685004335	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
710685004336	Transcriptional regulators [Transcription]; Region: GntR; COG1802
710685004337	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685004338	DNA-binding site [nucleotide binding]; DNA binding site
710685004339	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
710685004340	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
710685004341	substrate binding pocket [chemical binding]; other site
710685004342	membrane-bound complex binding site; other site
710685004343	hinge residues; other site
710685004344	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
710685004345	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685004346	dimer interface [polypeptide binding]; other site
710685004347	conserved gate region; other site
710685004348	putative PBP binding loops; other site
710685004349	ABC-ATPase subunit interface; other site
710685004350	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
710685004351	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
710685004352	Walker A/P-loop; other site
710685004353	ATP binding site [chemical binding]; other site
710685004354	Q-loop/lid; other site
710685004355	ABC transporter signature motif; other site
710685004356	Walker B; other site
710685004357	D-loop; other site
710685004358	H-loop/switch region; other site
710685004359	Helix-turn-helix domains; Region: HTH; cl00088
710685004360	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
710685004361	classical (c) SDRs; Region: SDR_c; cd05233
710685004362	NAD(P) binding site [chemical binding]; other site
710685004363	active site
710685004364	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
710685004365	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
710685004366	putative active site [active]
710685004367	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
710685004368	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
710685004369	active site
710685004370	HIGH motif; other site
710685004371	nucleotide binding site [chemical binding]; other site
710685004372	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
710685004373	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
710685004374	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
710685004375	active site
710685004376	KMSKS motif; other site
710685004377	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
710685004378	tRNA binding surface [nucleotide binding]; other site
710685004379	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
710685004380	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
710685004381	TIGR03084 family protein; Region: TIGR03084
710685004382	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
710685004383	Wyosine base formation; Region: Wyosine_form; pfam08608
710685004384	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
710685004385	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
710685004386	active site
710685004387	NTP binding site [chemical binding]; other site
710685004388	metal binding triad [ion binding]; metal-binding site
710685004389	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
710685004390	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
710685004391	Zn2+ binding site [ion binding]; other site
710685004392	Mg2+ binding site [ion binding]; other site
710685004393	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
710685004394	active site
710685004395	Ap6A binding site [chemical binding]; other site
710685004396	nudix motif; other site
710685004397	metal binding site [ion binding]; metal-binding site
710685004398	MviN-like protein; Region: MVIN; pfam03023
710685004399	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
710685004400	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685004401	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685004402	DNA binding residues [nucleotide binding]
710685004403	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
710685004404	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685004405	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
710685004406	catalytic residues [active]
710685004407	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
710685004408	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
710685004409	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
710685004410	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
710685004411	active site
710685004412	metal binding site [ion binding]; metal-binding site
710685004413	ParB-like partition proteins; Region: parB_part; TIGR00180
710685004414	ParB-like nuclease domain; Region: ParBc; cl02129
710685004415	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
710685004416	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
710685004417	P-loop; other site
710685004418	Magnesium ion binding site [ion binding]; other site
710685004419	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
710685004420	Magnesium ion binding site [ion binding]; other site
710685004421	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
710685004422	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
710685004423	G-X-X-G motif; other site
710685004424	R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297
710685004425	RxxxH motif; other site
710685004426	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
710685004427	Haemolytic domain; Region: Haemolytic; cl00506
710685004428	Ribonuclease P; Region: Ribonuclease_P; cl00457
710685004429	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
710685004430	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
710685004431	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685004432	Walker A motif; other site
710685004433	ATP binding site [chemical binding]; other site
710685004434	Walker B motif; other site
710685004435	arginine finger; other site
710685004436	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
710685004437	DnaA box-binding interface [nucleotide binding]; other site
710685004438	DNA polymerase III subunit beta; Validated; Region: PRK07761
710685004439	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
710685004440	putative DNA binding surface [nucleotide binding]; other site
710685004441	dimer interface [polypeptide binding]; other site
710685004442	beta-clamp/clamp loader binding surface; other site
710685004443	beta-clamp/translesion DNA polymerase binding surface; other site
710685004444	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
710685004445	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004446	NAD(P) binding pocket [chemical binding]; other site
710685004447	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
710685004448	recombination protein F; Reviewed; Region: recF; PRK00064
710685004449	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
710685004450	Walker A/P-loop; other site
710685004451	ATP binding site [chemical binding]; other site
710685004452	Q-loop/lid; other site
710685004453	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685004454	ABC transporter signature motif; other site
710685004455	Walker B; other site
710685004456	D-loop; other site
710685004457	H-loop/switch region; other site
710685004458	Protein of unknown function (DUF721); Region: DUF721; cl02324
710685004459	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
710685004460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
710685004461	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
710685004462	anchoring element; other site
710685004463	dimer interface [polypeptide binding]; other site
710685004464	ATP binding site [chemical binding]; other site
710685004465	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
710685004466	active site
710685004467	putative metal-binding site [ion binding]; other site
710685004468	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
710685004469	DNA gyrase subunit A; Validated; Region: PRK05560
710685004470	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
710685004471	CAP-like domain; other site
710685004472	active site
710685004473	primary dimer interface [polypeptide binding]; other site
710685004474	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
710685004475	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
710685004476	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
710685004477	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
710685004478	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
710685004479	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
710685004480	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
710685004481	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
710685004482	cyclase homology domain; Region: CHD; cd07302
710685004483	nucleotidyl binding site; other site
710685004484	metal binding site [ion binding]; metal-binding site
710685004485	dimer interface [polypeptide binding]; other site
710685004486	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
710685004487	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
710685004488	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
710685004489	active site
710685004490	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
710685004491	Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506
710685004492	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
710685004493	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
710685004494	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
710685004495	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
710685004496	Glutamine amidotransferase class-I; Region: GATase; pfam00117
710685004497	glutamine binding [chemical binding]; other site
710685004498	catalytic triad [active]
710685004499	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685004500	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685004501	active site
710685004502	ATP binding site [chemical binding]; other site
710685004503	substrate binding site [chemical binding]; other site
710685004504	activation loop (A-loop); other site
710685004505	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
710685004506	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
710685004507	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
710685004508	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
710685004509	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685004510	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685004511	active site
710685004512	ATP binding site [chemical binding]; other site
710685004513	substrate binding site [chemical binding]; other site
710685004514	activation loop (A-loop); other site
710685004515	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685004516	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
710685004517	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
710685004518	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
710685004519	active site
710685004520	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685004521	phosphopeptide binding site; other site
710685004522	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
710685004523	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685004524	phosphopeptide binding site; other site
710685004525	Helix-turn-helix domains; Region: HTH; cl00088
710685004526	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
710685004527	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
710685004528	molybdopterin cofactor binding site; other site
710685004529	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
710685004530	putative molybdopterin cofactor binding site; other site
710685004531	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685004532	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685004533	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685004534	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685004535	active site
710685004536	ATP binding site [chemical binding]; other site
710685004537	substrate binding site [chemical binding]; other site
710685004538	activation loop (A-loop); other site
710685004539	PknH-like extracellular domain; Region: PknH_C; pfam14032
710685004540	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
710685004541	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685004542	CoenzymeA binding site [chemical binding]; other site
710685004543	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685004544	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685004545	Pirin-related protein [General function prediction only]; Region: COG1741
710685004546	Cupin domain; Region: Cupin_2; cl09118
710685004547	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
710685004548	EVE domain; Region: EVE; cl00728
710685004549	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685004550	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685004551	active site
710685004552	ATP binding site [chemical binding]; other site
710685004553	substrate binding site [chemical binding]; other site
710685004554	activation loop (A-loop); other site
710685004555	Predicted membrane protein [Function unknown]; Region: COG3428
710685004556	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
710685004557	Helix-turn-helix domains; Region: HTH; cl00088
710685004558	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
710685004559	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685004560	Transcription factor WhiB; Region: Whib; pfam02467
710685004561	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
710685004562	Proteins of 100 residues with WXG; Region: WXG100; cl02005
710685004563	EspG family; Region: ESX-1_EspG; pfam14011
710685004564	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
710685004565	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685004566	Walker A motif; other site
710685004567	ATP binding site [chemical binding]; other site
710685004568	Walker B motif; other site
710685004569	arginine finger; other site
710685004570	Protein of unknown function (DUF690); Region: DUF690; cl04939
710685004571	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
710685004572	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685004573	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
710685004574	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685004575	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685004576	PPE family; Region: PPE; pfam00823
710685004577	Proteins of 100 residues with WXG; Region: WXG100; cl02005
710685004578	Proteins of 100 residues with WXG; Region: WXG100; cl02005
710685004579	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
710685004580	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
710685004581	P-loop; other site
710685004582	Magnesium ion binding site [ion binding]; other site
710685004583	Ubiquitin-like proteins; Region: UBQ; cl00155
710685004584	Ubiquitin-like proteins; Region: UBQ; cl00155
710685004585	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
710685004586	NodB motif; other site
710685004587	active site
710685004588	catalytic site [active]
710685004589	metal binding site [ion binding]; metal-binding site
710685004590	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685004591	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
710685004592	potassium/proton antiporter; Reviewed; Region: PRK05326
710685004593	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
710685004594	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
710685004595	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004596	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
710685004597	TIGR03086 family protein; Region: TIGR03086
710685004598	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
710685004599	Sulfate transporter family; Region: Sulfate_transp; cl15842
710685004600	Sulfate transporter family; Region: Sulfate_transp; cl15842
710685004601	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
710685004602	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685004603	dimerization interface [polypeptide binding]; other site
710685004604	putative DNA binding site [nucleotide binding]; other site
710685004605	putative Zn2+ binding site [ion binding]; other site
710685004606	hypothetical protein; Provisional; Region: PRK07945
710685004607	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
710685004608	yiaA/B two helix domain; Region: YiaAB; cl01759
710685004609	DNA polymerase IV; Validated; Region: PRK03858
710685004610	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
710685004611	active site
710685004612	DNA binding site [nucleotide binding]
710685004613	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685004614	Helix-turn-helix domains; Region: HTH; cl00088
710685004615	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685004616	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004617	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004618	NAD(P) binding pocket [chemical binding]; other site
710685004619	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
710685004620	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
710685004621	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
710685004622	DNA binding residues [nucleotide binding]
710685004623	dimer interface [polypeptide binding]; other site
710685004624	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
710685004625	Copper resistance protein D; Region: CopD; cl00563
710685004626	Bacterial Ig-like domain; Region: Big_5; cl01012
710685004627	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
710685004628	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
710685004629	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
710685004630	yybP-ykoY leader
710685004631	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
710685004632	Catalytic site [active]
710685004633	Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609
710685004634	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
710685004635	active site residue [active]
710685004636	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
710685004637	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
710685004638	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
710685004639	putative active site [active]
710685004640	catalytic site [active]
710685004641	putative metal binding site [ion binding]; other site
710685004642	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
710685004643	Ferritin-like domain; Region: Ferritin; pfam00210
710685004644	ferroxidase diiron center [ion binding]; other site
710685004645	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
710685004646	CAAX protease self-immunity; Region: Abi; cl00558
710685004647	prephenate dehydratase; Provisional; Region: PRK11898
710685004648	Prephenate dehydratase; Region: PDT; pfam00800
710685004649	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
710685004650	putative L-Phe binding site [chemical binding]; other site
710685004651	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
710685004652	catalytic core [active]
710685004653	Possibl zinc metallo-peptidase; Region: DUF1025; cl01577
710685004654	Septum formation; Region: Septum_form; pfam13845
710685004655	Septum formation; Region: Septum_form; pfam13845
710685004656	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
710685004657	seryl-tRNA synthetase; Provisional; Region: PRK05431
710685004658	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
710685004659	dimer interface [polypeptide binding]; other site
710685004660	active site
710685004661	motif 1; other site
710685004662	motif 2; other site
710685004663	motif 3; other site
710685004664	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685004665	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
710685004666	iron-sulfur cluster [ion binding]; other site
710685004667	[2Fe-2S] cluster binding site [ion binding]; other site
710685004668	Predicted ATPase [General function prediction only]; Region: COG3910
710685004669	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
710685004670	Walker A/P-loop; other site
710685004671	ATP binding site [chemical binding]; other site
710685004672	Q-loop/lid; other site
710685004673	ABC transporter signature motif; other site
710685004674	Walker B; other site
710685004675	D-loop; other site
710685004676	H-loop/switch region; other site
710685004677	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
710685004678	putative acyl-acceptor binding pocket; other site
710685004679	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
710685004680	putative acyl-acceptor binding pocket; other site
710685004681	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685004682	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
710685004683	active site
710685004684	motif I; other site
710685004685	motif II; other site
710685004686	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685004687	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
710685004688	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
710685004689	amidase catalytic site [active]
710685004690	Zn binding residues [ion binding]; other site
710685004691	substrate binding site [chemical binding]; other site
710685004692	LGFP repeat; Region: LGFP; pfam08310
710685004693	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
710685004694	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004695	UDP-galactopyranose mutase; Region: GLF; pfam03275
710685004696	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
710685004697	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
710685004698	active site
710685004699	UbiA prenyltransferase family; Region: UbiA; cl00337
710685004700	Predicted esterase [General function prediction only]; Region: COG0627
710685004701	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685004702	Predicted esterase [General function prediction only]; Region: COG0627
710685004703	Cutinase; Region: Cutinase; pfam01083
710685004704	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
710685004705	AMP-binding enzyme; Region: AMP-binding; cl15778
710685004706	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685004707	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
710685004708	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
710685004709	active site
710685004710	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
710685004711	Acyl transferase domain; Region: Acyl_transf_1; cl08282
710685004712	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685004713	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
710685004714	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
710685004715	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685004716	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685004717	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
710685004718	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685004719	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685004720	active site
710685004721	ATP binding site [chemical binding]; other site
710685004722	substrate binding site [chemical binding]; other site
710685004723	activation loop (A-loop); other site
710685004724	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685004725	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
710685004726	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
710685004727	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
710685004728	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
710685004729	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
710685004730	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
710685004731	classical (c) SDRs; Region: SDR_c; cd05233
710685004732	NAD(P) binding site [chemical binding]; other site
710685004733	active site
710685004734	FAD binding domain; Region: FAD_binding_4; pfam01565
710685004735	D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370
710685004736	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
710685004737	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
710685004738	Proteins of 100 residues with WXG; Region: WXG100; cl02005
710685004739	GtrA-like protein; Region: GtrA; cl00971
710685004740	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685004741	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
710685004742	DNA-binding site [nucleotide binding]; DNA binding site
710685004743	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
710685004744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685004745	homodimer interface [polypeptide binding]; other site
710685004746	catalytic residue [active]
710685004747	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685004748	Uncharacterized conserved protein [Function unknown]; Region: COG2128
710685004749	Phosphotransferase enzyme family; Region: APH; pfam01636
710685004750	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
710685004751	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685004752	Winged helix-turn helix; Region: HTH_29; pfam13551
710685004753	Integrase core domain; Region: rve; cl01316
710685004754	Integrase core domain; Region: rve_3; cl15866
710685004755	ABC-2 type transporter; Region: ABC2_membrane; cl11417
710685004756	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
710685004757	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
710685004758	active site
710685004759	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
710685004760	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
710685004761	Walker A/P-loop; other site
710685004762	ATP binding site [chemical binding]; other site
710685004763	Q-loop/lid; other site
710685004764	ABC transporter signature motif; other site
710685004765	Walker B; other site
710685004766	D-loop; other site
710685004767	H-loop/switch region; other site
710685004768	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
710685004769	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
710685004770	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
710685004771	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
710685004772	catalytic residue [active]
710685004773	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
710685004774	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
710685004775	NAD(P) binding site [chemical binding]; other site
710685004776	Helix-turn-helix domains; Region: HTH; cl00088
710685004777	Helix-turn-helix domains; Region: HTH; cl00088
710685004778	Predicted membrane protein [Function unknown]; Region: COG4425
710685004779	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
710685004780	enoyl-CoA hydratase; Provisional; Region: PRK06142
710685004781	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685004782	substrate binding site [chemical binding]; other site
710685004783	oxyanion hole (OAH) forming residues; other site
710685004784	trimer interface [polypeptide binding]; other site
710685004785	TIGR03086 family protein; Region: TIGR03086
710685004786	GXWXG protein; Region: GXWXG; pfam14231
710685004787	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
710685004788	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
710685004789	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
710685004790	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685004791	homodimer interface [polypeptide binding]; other site
710685004792	catalytic residue [active]
710685004793	DoxX; Region: DoxX; cl00976
710685004794	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
710685004795	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685004796	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685004797	DNA binding residues [nucleotide binding]
710685004798	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
710685004799	iron-sulfur cluster [ion binding]; other site
710685004800	[2Fe-2S] cluster binding site [ion binding]; other site
710685004801	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
710685004802	active site
710685004803	metal binding site [ion binding]; metal-binding site
710685004804	homotetramer interface [polypeptide binding]; other site
710685004805	Protein of unknown function (DUF419); Region: DUF419; cl15265
710685004806	short chain dehydrogenase; Provisional; Region: PRK07825
710685004807	classical (c) SDRs; Region: SDR_c; cd05233
710685004808	NAD(P) binding site [chemical binding]; other site
710685004809	active site
710685004810	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
710685004811	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685004812	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
710685004813	apolar tunnel; other site
710685004814	heme binding site [chemical binding]; other site
710685004815	dimerization interface [polypeptide binding]; other site
710685004816	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
710685004817	classical (c) SDRs; Region: SDR_c; cd05233
710685004818	NAD(P) binding site [chemical binding]; other site
710685004819	active site
710685004820	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
710685004821	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
710685004822	catalytic core [active]
710685004823	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
710685004824	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
710685004825	putative active site [active]
710685004826	putative substrate binding site [chemical binding]; other site
710685004827	ATP binding site [chemical binding]; other site
710685004828	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
710685004829	NMT1-like family; Region: NMT1_2; cl15260
710685004830	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
710685004831	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
710685004832	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295
710685004833	Walker A/P-loop; other site
710685004834	ATP binding site [chemical binding]; other site
710685004835	Q-loop/lid; other site
710685004836	ABC transporter signature motif; other site
710685004837	Walker B; other site
710685004838	D-loop; other site
710685004839	H-loop/switch region; other site
710685004840	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
710685004841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685004842	putative PBP binding loops; other site
710685004843	dimer interface [polypeptide binding]; other site
710685004844	ABC-ATPase subunit interface; other site
710685004845	Putative glycolipid-binding; Region: Glycolipid_bind; cl01425
710685004846	prephenate dehydrogenase; Validated; Region: PRK06545
710685004847	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004848	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
710685004849	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
710685004850	nucleoside/Zn binding site; other site
710685004851	dimer interface [polypeptide binding]; other site
710685004852	catalytic motif [active]
710685004853	Protein of unknown function (DUF732); Region: DUF732; pfam05305
710685004854	PAS fold; Region: PAS_2; pfam08446
710685004855	GAF domain; Region: GAF; cl15785
710685004856	Phytochrome region; Region: PHY; pfam00360
710685004857	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
710685004858	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
710685004859	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004860	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
710685004861	NAD(P) binding site [chemical binding]; other site
710685004862	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685004863	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
710685004864	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685004865	active site
710685004866	metal binding site [ion binding]; metal-binding site
710685004867	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685004868	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004869	Response regulator receiver domain; Region: Response_reg; pfam00072
710685004870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685004871	active site
710685004872	phosphorylation site [posttranslational modification]
710685004873	intermolecular recognition site; other site
710685004874	dimerization interface [polypeptide binding]; other site
710685004875	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
710685004876	CHASE3 domain; Region: CHASE3; cl05000
710685004877	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
710685004878	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685004879	dimer interface [polypeptide binding]; other site
710685004880	phosphorylation site [posttranslational modification]
710685004881	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685004882	ATP binding site [chemical binding]; other site
710685004883	Mg2+ binding site [ion binding]; other site
710685004884	G-X-G motif; other site
710685004885	Response regulator receiver domain; Region: Response_reg; pfam00072
710685004886	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685004887	active site
710685004888	phosphorylation site [posttranslational modification]
710685004889	intermolecular recognition site; other site
710685004890	dimerization interface [polypeptide binding]; other site
710685004891	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
710685004892	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
710685004893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
710685004894	Protein of unknown function (DUF732); Region: DUF732; pfam05305
710685004895	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
710685004896	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
710685004897	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
710685004898	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
710685004899	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
710685004900	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004901	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
710685004902	Helix-turn-helix domains; Region: HTH; cl00088
710685004903	Integrase core domain; Region: rve; cl01316
710685004904	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
710685004905	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
710685004906	Walker A/P-loop; other site
710685004907	ATP binding site [chemical binding]; other site
710685004908	Q-loop/lid; other site
710685004909	ABC transporter signature motif; other site
710685004910	Walker B; other site
710685004911	D-loop; other site
710685004912	H-loop/switch region; other site
710685004913	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
710685004914	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
710685004915	substrate binding pocket [chemical binding]; other site
710685004916	membrane-bound complex binding site; other site
710685004917	hinge residues; other site
710685004918	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
710685004919	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685004920	dimer interface [polypeptide binding]; other site
710685004921	conserved gate region; other site
710685004922	putative PBP binding loops; other site
710685004923	ABC-ATPase subunit interface; other site
710685004924	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
710685004925	Tubulin C-terminal domain; Region: Tubulin_C; cl10021
710685004926	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
710685004927	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
710685004928	active site
710685004929	HIGH motif; other site
710685004930	nucleotide binding site [chemical binding]; other site
710685004931	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
710685004932	active site
710685004933	KMSKS motif; other site
710685004934	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004935	hypothetical protein; Provisional; Region: PRK07588
710685004936	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
710685004937	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
710685004938	active site
710685004939	DNA binding site [nucleotide binding]
710685004940	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
710685004941	DNA binding site [nucleotide binding]
710685004942	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
710685004943	Transport protein; Region: actII; TIGR00833
710685004944	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685004945	Helix-turn-helix domains; Region: HTH; cl00088
710685004946	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
710685004947	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
710685004948	Fibronectin type III-like domain; Region: Fn3-like; cl15273
710685004949	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
710685004950	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
710685004951	tetramer interface [polypeptide binding]; other site
710685004952	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685004953	catalytic residue [active]
710685004954	Predicted dehydrogenase [General function prediction only]; Region: COG0579
710685004955	glycerol kinase; Region: glycerol_kin; TIGR01311
710685004956	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
710685004957	N- and C-terminal domain interface [polypeptide binding]; other site
710685004958	active site
710685004959	MgATP binding site [chemical binding]; other site
710685004960	catalytic site [active]
710685004961	metal binding site [ion binding]; metal-binding site
710685004962	carbohydrate binding site [chemical binding]; other site
710685004963	Short C-terminal domain; Region: SHOCT; cl01373
710685004964	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
710685004965	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
710685004966	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685004967	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685004968	dimerization interface [polypeptide binding]; other site
710685004969	putative DNA binding site [nucleotide binding]; other site
710685004970	putative Zn2+ binding site [ion binding]; other site
710685004971	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
710685004972	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
710685004973	active site
710685004974	DNA binding site [nucleotide binding]
710685004975	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
710685004976	DNA binding site [nucleotide binding]
710685004977	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
710685004978	active site
710685004979	catalytic residues [active]
710685004980	DNA binding site [nucleotide binding]
710685004981	Int/Topo IB signature motif; other site
710685004982	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
710685004983	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685004984	active site
710685004985	DNA binding site [nucleotide binding]
710685004986	Int/Topo IB signature motif; other site
710685004987	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
710685004988	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
710685004989	DNA binding site [nucleotide binding]
710685004990	active site
710685004991	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
710685004992	DNA binding site [nucleotide binding]
710685004993	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
710685004994	nucleotide binding site [chemical binding]; other site
710685004995	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
710685004996	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685004997	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685004998	S-adenosylmethionine binding site [chemical binding]; other site
710685004999	Cutinase; Region: Cutinase; pfam01083
710685005000	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685005001	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685005002	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685005003	active site
710685005004	ATP binding site [chemical binding]; other site
710685005005	substrate binding site [chemical binding]; other site
710685005006	activation loop (A-loop); other site
710685005007	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
710685005008	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685005009	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685005010	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005011	Helix-turn-helix domains; Region: HTH; cl00088
710685005012	DNA-binding interface [nucleotide binding]; DNA binding site
710685005013	tetracycline repressor protein TetR; Provisional; Region: PRK13756
710685005014	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
710685005015	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
710685005016	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
710685005017	protein binding site [polypeptide binding]; other site
710685005018	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
710685005019	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
710685005020	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
710685005021	catalytic residue [active]
710685005022	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
710685005023	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685005024	Walker A motif; other site
710685005025	ATP binding site [chemical binding]; other site
710685005026	Walker B motif; other site
710685005027	arginine finger; other site
710685005028	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
710685005029	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952
710685005030	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
710685005031	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685005032	S-adenosylmethionine binding site [chemical binding]; other site
710685005033	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
710685005034	FAD binding domain; Region: FAD_binding_4; pfam01565
710685005035	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685005036	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
710685005037	active site
710685005038	metal binding site [ion binding]; metal-binding site
710685005039	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
710685005040	recombination protein RecR; Reviewed; Region: recR; PRK00076
710685005041	RecR protein; Region: RecR; pfam02132
710685005042	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
710685005043	putative active site [active]
710685005044	putative metal-binding site [ion binding]; other site
710685005045	tetramer interface [polypeptide binding]; other site
710685005046	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
710685005047	catalytic triad [active]
710685005048	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
710685005049	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
710685005050	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
710685005051	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
710685005052	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
710685005053	active site
710685005054	catalytic site [active]
710685005055	substrate binding site [chemical binding]; other site
710685005056	2-isopropylmalate synthase; Validated; Region: PRK03739
710685005057	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
710685005058	active site
710685005059	catalytic residues [active]
710685005060	metal binding site [ion binding]; metal-binding site
710685005061	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
710685005062	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
710685005063	non-specific DNA binding site [nucleotide binding]; other site
710685005064	salt bridge; other site
710685005065	sequence-specific DNA binding site [nucleotide binding]; other site
710685005066	Cupin domain; Region: Cupin_2; cl09118
710685005067	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
710685005068	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
710685005069	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
710685005070	active site
710685005071	FMN binding site [chemical binding]; other site
710685005072	substrate binding site [chemical binding]; other site
710685005073	3Fe-4S cluster binding site [ion binding]; other site
710685005074	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
710685005075	domain_subunit interface; other site
710685005076	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
710685005077	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
710685005078	active site
710685005079	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
710685005080	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
710685005081	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
710685005082	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
710685005083	aspartate kinase; Reviewed; Region: PRK06635
710685005084	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
710685005085	putative nucleotide binding site [chemical binding]; other site
710685005086	putative catalytic residues [active]
710685005087	putative Mg ion binding site [ion binding]; other site
710685005088	putative aspartate binding site [chemical binding]; other site
710685005089	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
710685005090	putative allosteric regulatory site; other site
710685005091	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
710685005092	putative allosteric regulatory residue; other site
710685005093	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
710685005094	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005095	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
710685005096	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
710685005097	hydroperoxidase II; Provisional; Region: katE; PRK11249
710685005098	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
710685005099	heme binding pocket [chemical binding]; other site
710685005100	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
710685005101	domain interactions; other site
710685005102	FAD dependent oxidoreductase; Region: DAO; pfam01266
710685005103	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005104	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
710685005105	iron-sulfur cluster [ion binding]; other site
710685005106	[2Fe-2S] cluster binding site [ion binding]; other site
710685005107	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
710685005108	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
710685005109	tetramer interface [polypeptide binding]; other site
710685005110	heme binding pocket [chemical binding]; other site
710685005111	NADPH binding site [chemical binding]; other site
710685005112	OsmC-like protein; Region: OsmC; cl00767
710685005113	PknH-like extracellular domain; Region: PknH_C; pfam14032
710685005114	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
710685005115	TIGR03440 family protein; Region: unchr_TIGR03440
710685005116	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
710685005117	TIGR03442 family protein; Region: TIGR03442
710685005118	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
710685005119	putative active site [active]
710685005120	putative dimer interface [polypeptide binding]; other site
710685005121	probable methyltransferase; Region: TIGR03438
710685005122	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
710685005123	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
710685005124	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
710685005125	catalytic residue [active]
710685005126	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
710685005127	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685005128	S-adenosylmethionine binding site [chemical binding]; other site
710685005129	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685005130	S-adenosylmethionine binding site [chemical binding]; other site
710685005131	glycerol kinase; Provisional; Region: glpK; PRK00047
710685005132	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
710685005133	N- and C-terminal domain interface [polypeptide binding]; other site
710685005134	putative active site [active]
710685005135	putative MgATP binding site [chemical binding]; other site
710685005136	catalytic site [active]
710685005137	metal binding site [ion binding]; metal-binding site
710685005138	putative homotetramer interface [polypeptide binding]; other site
710685005139	putative glycerol binding site [chemical binding]; other site
710685005140	homodimer interface [polypeptide binding]; other site
710685005141	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
710685005142	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
710685005143	active site
710685005144	catalytic tetrad [active]
710685005145	Helix-turn-helix domains; Region: HTH; cl00088
710685005146	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
710685005147	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
710685005148	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
710685005149	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
710685005150	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
710685005151	RDD family; Region: RDD; cl00746
710685005152	Integral membrane protein DUF95; Region: DUF95; cl00572
710685005153	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
710685005154	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685005155	MoxR-like ATPases [General function prediction only]; Region: COG0714
710685005156	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685005157	Walker A motif; other site
710685005158	ATP binding site [chemical binding]; other site
710685005159	Walker B motif; other site
710685005160	arginine finger; other site
710685005161	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
710685005162	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
710685005163	GatB domain; Region: GatB_Yqey; cl11497
710685005164	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
710685005165	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
710685005166	putative methyltransferase; Provisional; Region: PRK14968
710685005167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685005168	S-adenosylmethionine binding site [chemical binding]; other site
710685005169	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748
710685005170	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
710685005171	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
710685005172	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
710685005173	catalytic residue [active]
710685005174	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
710685005175	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
710685005176	putative active site [active]
710685005177	putative metal binding site [ion binding]; other site
710685005178	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
710685005179	Transglycosylase; Region: Transgly; cl07896
710685005180	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685005181	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
710685005182	Transcription factor WhiB; Region: Whib; pfam02467
710685005183	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
710685005184	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
710685005185	DTAP/Switch II; other site
710685005186	Switch I; other site
710685005187	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685005188	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
710685005189	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
710685005190	P loop; other site
710685005191	Nucleotide binding site [chemical binding]; other site
710685005192	DTAP/Switch II; other site
710685005193	Switch I; other site
710685005194	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
710685005195	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
710685005196	homotrimer interaction site [polypeptide binding]; other site
710685005197	putative active site [active]
710685005198	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685005199	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
710685005200	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
710685005201	ligand binding site [chemical binding]; other site
710685005202	flexible hinge region; other site
710685005203	Helix-turn-helix domains; Region: HTH; cl00088
710685005204	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
710685005205	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
710685005206	minor groove reading motif; other site
710685005207	helix-hairpin-helix signature motif; other site
710685005208	substrate binding pocket [chemical binding]; other site
710685005209	active site
710685005210	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
710685005211	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
710685005212	catalytic residues [active]
710685005213	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
710685005214	putative active site [active]
710685005215	putative CoA binding site [chemical binding]; other site
710685005216	nudix motif; other site
710685005217	metal binding site [ion binding]; metal-binding site
710685005218	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
710685005219	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685005220	Protein of unknown function (DUF1469); Region: DUF1469; cl12095
710685005221	acetyl-CoA synthetase; Provisional; Region: PRK00174
710685005222	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
710685005223	AMP-binding enzyme; Region: AMP-binding; cl15778
710685005224	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685005225	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
710685005226	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685005227	motif II; other site
710685005228	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
710685005229	helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819
710685005230	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
710685005231	ATP binding site [chemical binding]; other site
710685005232	Walker A motif; other site
710685005233	hexamer interface [polypeptide binding]; other site
710685005234	Walker B motif; other site
710685005235	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
710685005236	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
710685005237	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
710685005238	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
710685005239	ATP binding site [chemical binding]; other site
710685005240	putative Mg++ binding site [ion binding]; other site
710685005241	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685005242	ATP-binding site [chemical binding]; other site
710685005243	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
710685005244	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
710685005245	DNA-binding site [nucleotide binding]; DNA binding site
710685005246	RNA-binding motif; other site
710685005247	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
710685005248	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
710685005249	active site
710685005250	interdomain interaction site; other site
710685005251	putative metal-binding site [ion binding]; other site
710685005252	nucleotide binding site [chemical binding]; other site
710685005253	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
710685005254	domain I; other site
710685005255	phosphate binding site [ion binding]; other site
710685005256	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
710685005257	domain II; other site
710685005258	domain III; other site
710685005259	nucleotide binding site [chemical binding]; other site
710685005260	DNA binding groove [nucleotide binding]
710685005261	catalytic site [active]
710685005262	domain IV; other site
710685005263	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
710685005264	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
710685005265	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
710685005266	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
710685005267	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
710685005268	cyclase homology domain; Region: CHD; cd07302
710685005269	nucleotidyl binding site; other site
710685005270	metal binding site [ion binding]; metal-binding site
710685005271	dimer interface [polypeptide binding]; other site
710685005272	DNA polymerase III subunit delta'; Validated; Region: PRK07940
710685005273	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685005274	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685005275	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
710685005276	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005277	NAD(P) binding site [chemical binding]; other site
710685005278	active site
710685005279	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
710685005280	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
710685005281	active site
710685005282	putative substrate binding pocket [chemical binding]; other site
710685005283	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685005284	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
710685005285	Zn binding site [ion binding]; other site
710685005286	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
710685005287	AMP-binding enzyme; Region: AMP-binding; cl15778
710685005288	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685005289	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
710685005290	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
710685005291	putative trimer interface [polypeptide binding]; other site
710685005292	putative CoA binding site [chemical binding]; other site
710685005293	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
710685005294	putative trimer interface [polypeptide binding]; other site
710685005295	putative CoA binding site [chemical binding]; other site
710685005296	yybP-ykoY leader
710685005297	Integral membrane protein TerC family; Region: TerC; cl10468
710685005298	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685005299	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
710685005300	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
710685005301	dimer interface [polypeptide binding]; other site
710685005302	substrate binding site [chemical binding]; other site
710685005303	metal binding sites [ion binding]; metal-binding site
710685005304	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685005305	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
710685005306	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
710685005307	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
710685005308	Ligand Binding Site [chemical binding]; other site
710685005309	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
710685005310	active site
710685005311	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
710685005312	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
710685005313	putative [Fe4-S4] binding site [ion binding]; other site
710685005314	putative molybdopterin cofactor binding site [chemical binding]; other site
710685005315	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
710685005316	putative molybdopterin cofactor binding site; other site
710685005317	Protein of unknown function (DUF541); Region: SIMPL; cl01077
710685005318	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685005319	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685005320	FtsH Extracellular; Region: FtsH_ext; pfam06480
710685005321	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
710685005322	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685005323	Walker A motif; other site
710685005324	ATP binding site [chemical binding]; other site
710685005325	Walker B motif; other site
710685005326	arginine finger; other site
710685005327	Peptidase family M41; Region: Peptidase_M41; pfam01434
710685005328	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
710685005329	homodecamer interface [polypeptide binding]; other site
710685005330	GTP cyclohydrolase I; Provisional; Region: PLN03044
710685005331	active site
710685005332	putative catalytic site residues [active]
710685005333	zinc binding site [ion binding]; other site
710685005334	GTP-CH-I/GFRP interaction surface; other site
710685005335	dihydropteroate synthase; Region: DHPS; TIGR01496
710685005336	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
710685005337	substrate binding pocket [chemical binding]; other site
710685005338	dimer interface [polypeptide binding]; other site
710685005339	inhibitor binding site; inhibition site
710685005340	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
710685005341	homooctamer interface [polypeptide binding]; other site
710685005342	active site
710685005343	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
710685005344	catalytic center binding site [active]
710685005345	ATP binding site [chemical binding]; other site
710685005346	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
710685005347	Uncharacterized conserved protein [Function unknown]; Region: COG5495
710685005348	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005349	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
710685005350	Pantoate-beta-alanine ligase; Region: PanC; cd00560
710685005351	pantoate--beta-alanine ligase; Region: panC; TIGR00018
710685005352	active site
710685005353	ATP-binding site [chemical binding]; other site
710685005354	pantoate-binding site; other site
710685005355	HXXH motif; other site
710685005356	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
710685005357	tetramerization interface [polypeptide binding]; other site
710685005358	active site
710685005359	Type III pantothenate kinase; Region: Pan_kinase; cl09130
710685005360	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
710685005361	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
710685005362	active site
710685005363	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
710685005364	dimer interface [polypeptide binding]; other site
710685005365	substrate binding site [chemical binding]; other site
710685005366	catalytic residue [active]
710685005367	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
710685005368	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
710685005369	dimer interface [polypeptide binding]; other site
710685005370	putative anticodon binding site; other site
710685005371	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
710685005372	motif 1; other site
710685005373	dimer interface [polypeptide binding]; other site
710685005374	active site
710685005375	motif 2; other site
710685005376	motif 3; other site
710685005377	Lsr2; Region: Lsr2; pfam11774
710685005378	Clp protease ATP binding subunit; Region: clpC; CHL00095
710685005379	Clp amino terminal domain; Region: Clp_N; pfam02861
710685005380	Clp amino terminal domain; Region: Clp_N; pfam02861
710685005381	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685005382	Walker A motif; other site
710685005383	ATP binding site [chemical binding]; other site
710685005384	Walker B motif; other site
710685005385	arginine finger; other site
710685005386	UvrB/uvrC motif; Region: UVR; pfam02151
710685005387	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685005388	Walker A motif; other site
710685005389	ATP binding site [chemical binding]; other site
710685005390	Walker B motif; other site
710685005391	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
710685005392	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
710685005393	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
710685005394	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
710685005395	catalytic core [active]
710685005396	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
710685005397	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685005398	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
710685005399	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685005400	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
710685005401	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
710685005402	conserved cys residue [active]
710685005403	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685005404	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685005405	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685005406	cyclase homology domain; Region: CHD; cd07302
710685005407	nucleotidyl binding site; other site
710685005408	metal binding site [ion binding]; metal-binding site
710685005409	dimer interface [polypeptide binding]; other site
710685005410	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
710685005411	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
710685005412	minor groove reading motif; other site
710685005413	helix-hairpin-helix signature motif; other site
710685005414	substrate binding pocket [chemical binding]; other site
710685005415	active site
710685005416	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
710685005417	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
710685005418	active site clefts [active]
710685005419	zinc binding site [ion binding]; other site
710685005420	dimer interface [polypeptide binding]; other site
710685005421	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
710685005422	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
710685005423	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
710685005424	DNA repair protein RadA; Provisional; Region: PRK11823
710685005425	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
710685005426	Walker A motif/ATP binding site; other site
710685005427	ATP binding site [chemical binding]; other site
710685005428	Walker B motif; other site
710685005429	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
710685005430	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
710685005431	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
710685005432	homotrimer interaction site [polypeptide binding]; other site
710685005433	zinc binding site [ion binding]; other site
710685005434	CDP-binding sites; other site
710685005435	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
710685005436	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
710685005437	active site
710685005438	HIGH motif; other site
710685005439	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
710685005440	KMSKS motif; other site
710685005441	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
710685005442	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
710685005443	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
710685005444	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
710685005445	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
710685005446	active site
710685005447	catalytic triad [active]
710685005448	oxyanion hole [active]
710685005449	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
710685005450	transmembrane helices; other site
710685005451	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685005452	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
710685005453	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685005454	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
710685005455	LamB/YcsF family; Region: LamB_YcsF; cl00664
710685005456	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
710685005457	putative FMN binding site [chemical binding]; other site
710685005458	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
710685005459	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
710685005460	active site residue [active]
710685005461	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
710685005462	active site residue [active]
710685005463	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
710685005464	putative PBP binding regions; other site
710685005465	ABC-ATPase subunit  interface; other site
710685005466	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
710685005467	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685005468	Walker A/P-loop; other site
710685005469	ATP binding site [chemical binding]; other site
710685005470	Q-loop/lid; other site
710685005471	ABC transporter signature motif; other site
710685005472	Walker B; other site
710685005473	D-loop; other site
710685005474	H-loop/switch region; other site
710685005475	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
710685005476	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
710685005477	intersubunit interface [polypeptide binding]; other site
710685005478	Transcriptional regulators [Transcription]; Region: PurR; COG1609
710685005479	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
710685005480	DNA binding site [nucleotide binding]
710685005481	domain linker motif; other site
710685005482	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
710685005483	putative dimerization interface [polypeptide binding]; other site
710685005484	putative ligand binding site [chemical binding]; other site
710685005485	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685005486	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685005487	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
710685005488	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685005489	Helix-turn-helix domains; Region: HTH; cl00088
710685005490	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685005491	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
710685005492	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685005493	active site
710685005494	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685005495	active site
710685005496	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
710685005497	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
710685005498	FAD binding pocket [chemical binding]; other site
710685005499	FAD binding motif [chemical binding]; other site
710685005500	phosphate binding motif [ion binding]; other site
710685005501	beta-alpha-beta structure motif; other site
710685005502	NAD(p) ribose binding residues [chemical binding]; other site
710685005503	NAD binding pocket [chemical binding]; other site
710685005504	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
710685005505	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685005506	catalytic loop [active]
710685005507	iron binding site [ion binding]; other site
710685005508	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685005509	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
710685005510	Flavin binding site [chemical binding]; other site
710685005511	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
710685005512	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685005513	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
710685005514	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
710685005515	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
710685005516	active site
710685005517	Fe binding site [ion binding]; other site
710685005518	Flavin Reductases; Region: FlaRed; cl00801
710685005519	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
710685005520	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685005521	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685005522	Transcriptional regulator [Transcription]; Region: LysR; COG0583
710685005523	Helix-turn-helix domains; Region: HTH; cl00088
710685005524	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685005525	dimerization interface [polypeptide binding]; other site
710685005526	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685005527	metabolite-proton symporter; Region: 2A0106; TIGR00883
710685005528	putative substrate translocation pore; other site
710685005529	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005530	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
710685005531	NAD(P) binding site [chemical binding]; other site
710685005532	active site
710685005533	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
710685005534	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
710685005535	AMP-binding enzyme; Region: AMP-binding; cl15778
710685005536	Transposase; Region: DEDD_Tnp_IS110; pfam01548
710685005537	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
710685005538	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685005539	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685005540	active site
710685005541	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
710685005542	aspartate aminotransferase; Provisional; Region: PRK05764
710685005543	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
710685005544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685005545	homodimer interface [polypeptide binding]; other site
710685005546	catalytic residue [active]
710685005547	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
710685005548	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685005549	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
710685005550	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685005551	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685005552	active site
710685005553	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685005554	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685005555	active site
710685005556	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685005557	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685005558	active site
710685005559	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
710685005560	AMP-binding enzyme; Region: AMP-binding; cl15778
710685005561	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685005562	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
710685005563	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685005564	active site
710685005565	short chain dehydrogenase; Provisional; Region: PRK07831
710685005566	classical (c) SDRs; Region: SDR_c; cd05233
710685005567	NAD(P) binding site [chemical binding]; other site
710685005568	active site
710685005569	Helix-turn-helix domains; Region: HTH; cl00088
710685005570	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
710685005571	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
710685005572	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
710685005573	dimer interface [polypeptide binding]; other site
710685005574	active site
710685005575	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
710685005576	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
710685005577	NAD binding site [chemical binding]; other site
710685005578	catalytic Zn binding site [ion binding]; other site
710685005579	substrate binding site [chemical binding]; other site
710685005580	structural Zn binding site [ion binding]; other site
710685005581	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685005582	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685005583	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
710685005584	Transport protein; Region: actII; TIGR00833
710685005585	Protein export membrane protein; Region: SecD_SecF; cl14618
710685005586	Condensation domain; Region: Condensation; pfam00668
710685005587	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
710685005588	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685005589	ATP binding site [chemical binding]; other site
710685005590	Mg2+ binding site [ion binding]; other site
710685005591	G-X-G motif; other site
710685005592	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
710685005593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685005594	active site
710685005595	phosphorylation site [posttranslational modification]
710685005596	intermolecular recognition site; other site
710685005597	dimerization interface [polypeptide binding]; other site
710685005598	Helix-turn-helix domains; Region: HTH; cl00088
710685005599	Nitronate monooxygenase; Region: NMO; pfam03060
710685005600	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
710685005601	FMN binding site [chemical binding]; other site
710685005602	substrate binding site [chemical binding]; other site
710685005603	putative catalytic residue [active]
710685005604	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
710685005605	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
710685005606	enoyl-CoA hydratase; Provisional; Region: PRK06495
710685005607	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685005608	substrate binding site [chemical binding]; other site
710685005609	oxyanion hole (OAH) forming residues; other site
710685005610	trimer interface [polypeptide binding]; other site
710685005611	short chain dehydrogenase; Provisional; Region: PRK07856
710685005612	classical (c) SDRs; Region: SDR_c; cd05233
710685005613	NAD(P) binding site [chemical binding]; other site
710685005614	active site
710685005615	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
710685005616	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685005617	homodimer interface [polypeptide binding]; other site
710685005618	NAD binding site [chemical binding]; other site
710685005619	active site
710685005620	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685005621	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685005622	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
710685005623	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
710685005624	dimer interface [polypeptide binding]; other site
710685005625	active site
710685005626	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685005627	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
710685005628	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685005629	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685005630	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685005631	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685005632	active site
710685005633	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
710685005634	active site
710685005635	catalytic site [active]
710685005636	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
710685005637	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685005638	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
710685005639	putative active site [active]
710685005640	putative catalytic site [active]
710685005641	lipid-transfer protein; Provisional; Region: PRK07855
710685005642	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685005643	active site
710685005644	enoyl-CoA hydratase; Region: PLN02864
710685005645	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685005646	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
710685005647	dimer interaction site [polypeptide binding]; other site
710685005648	substrate-binding tunnel; other site
710685005649	active site
710685005650	catalytic site [active]
710685005651	substrate binding site [chemical binding]; other site
710685005652	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
710685005653	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
710685005654	acetaldehyde dehydrogenase; Validated; Region: PRK08300
710685005655	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005656	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
710685005657	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
710685005658	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
710685005659	active site
710685005660	catalytic residues [active]
710685005661	metal binding site [ion binding]; metal-binding site
710685005662	DmpG-like communication domain; Region: DmpG_comm; pfam07836
710685005663	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
710685005664	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
710685005665	ATP binding site [chemical binding]; other site
710685005666	putative Mg++ binding site [ion binding]; other site
710685005667	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685005668	nucleotide binding region [chemical binding]; other site
710685005669	ATP-binding site [chemical binding]; other site
710685005670	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
710685005671	active site
710685005672	Transcriptional regulator [Transcription]; Region: IclR; COG1414
710685005673	Helix-turn-helix domains; Region: HTH; cl00088
710685005674	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685005675	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005676	NAD(P) binding site [chemical binding]; other site
710685005677	active site
710685005678	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
710685005679	PknH-like extracellular domain; Region: PknH_C; pfam14032
710685005680	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
710685005681	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
710685005682	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
710685005683	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
710685005684	trimer interface [polypeptide binding]; other site
710685005685	putative metal binding site [ion binding]; other site
710685005686	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
710685005687	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
710685005688	MOSC domain; Region: MOSC; pfam03473
710685005689	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685005690	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685005691	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
710685005692	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
710685005693	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685005694	active site
710685005695	lipid-transfer protein; Provisional; Region: PRK07937
710685005696	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685005697	active site
710685005698	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
710685005699	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685005700	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685005701	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
710685005702	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
710685005703	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
710685005704	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685005705	enoyl-CoA hydratase; Provisional; Region: PRK07799
710685005706	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685005707	substrate binding site [chemical binding]; other site
710685005708	oxyanion hole (OAH) forming residues; other site
710685005709	trimer interface [polypeptide binding]; other site
710685005710	acyl-CoA synthetase; Validated; Region: PRK07798
710685005711	AMP-binding enzyme; Region: AMP-binding; cl15778
710685005712	Nitronate monooxygenase; Region: NMO; pfam03060
710685005713	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
710685005714	FMN binding site [chemical binding]; other site
710685005715	substrate binding site [chemical binding]; other site
710685005716	putative catalytic residue [active]
710685005717	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
710685005718	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
710685005719	Helix-turn-helix domains; Region: HTH; cl00088
710685005720	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
710685005721	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005722	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
710685005723	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
710685005724	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005725	NAD(P) binding site [chemical binding]; other site
710685005726	active site
710685005727	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
710685005728	active site
710685005729	FMN binding site [chemical binding]; other site
710685005730	substrate binding site [chemical binding]; other site
710685005731	putative catalytic residue [active]
710685005732	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
710685005733	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
710685005734	active site
710685005735	TDP-binding site; other site
710685005736	acceptor substrate-binding pocket; other site
710685005737	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685005738	Helix-turn-helix domains; Region: HTH; cl00088
710685005739	acyl-CoA synthetase; Validated; Region: PRK07867
710685005740	AMP-binding enzyme; Region: AMP-binding; cl15778
710685005741	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685005742	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685005743	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
710685005744	active site
710685005745	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685005746	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
710685005747	FAD binding site [chemical binding]; other site
710685005748	substrate binding site [chemical binding]; other site
710685005749	catalytic base [active]
710685005750	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
710685005751	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
710685005752	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
710685005753	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005754	NAD(P) binding site [chemical binding]; other site
710685005755	active site
710685005756	Permease; Region: Permease; cl00510
710685005757	Permease; Region: Permease; cl00510
710685005758	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685005759	mce related protein; Region: MCE; pfam02470
710685005760	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685005761	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685005762	mce related protein; Region: MCE; pfam02470
710685005763	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685005764	mce related protein; Region: MCE; pfam02470
710685005765	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685005766	mce related protein; Region: MCE; pfam02470
710685005767	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685005768	mce related protein; Region: MCE; pfam02470
710685005769	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685005770	mce related protein; Region: MCE; pfam02470
710685005771	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
710685005772	Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982
710685005773	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
710685005774	active site
710685005775	homotetramer interface [polypeptide binding]; other site
710685005776	enoyl-CoA hydratase; Provisional; Region: PRK08290
710685005777	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685005778	substrate binding site [chemical binding]; other site
710685005779	oxyanion hole (OAH) forming residues; other site
710685005780	trimer interface [polypeptide binding]; other site
710685005781	classical (c) SDRs; Region: SDR_c; cd05233
710685005782	NAD(P) binding site [chemical binding]; other site
710685005783	active site
710685005784	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685005785	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685005786	active site
710685005787	GXWXG protein; Region: GXWXG; pfam14231
710685005788	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
710685005789	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
710685005790	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
710685005791	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685005792	catalytic loop [active]
710685005793	iron binding site [ion binding]; other site
710685005794	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
710685005795	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
710685005796	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
710685005797	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
710685005798	putative hydrophobic ligand binding site [chemical binding]; other site
710685005799	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
710685005800	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
710685005801	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
710685005802	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
710685005803	XdhC Rossmann domain; Region: XdhC_C; pfam13478
710685005804	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685005805	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
710685005806	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
710685005807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685005808	D-galactonate transporter; Region: 2A0114; TIGR00893
710685005809	putative substrate translocation pore; other site
710685005810	Prostaglandin dehydrogenases; Region: PGDH; cd05288
710685005811	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
710685005812	NAD(P) binding site [chemical binding]; other site
710685005813	substrate binding site [chemical binding]; other site
710685005814	dimer interface [polypeptide binding]; other site
710685005815	Cutinase; Region: Cutinase; pfam01083
710685005816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005817	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
710685005818	NAD(P) binding site [chemical binding]; other site
710685005819	active site
710685005820	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685005821	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
710685005822	Helix-turn-helix domains; Region: HTH; cl00088
710685005823	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
710685005824	Oligosaccharyltransferase 48 kDa subunit beta; Region: DDOST_48kD; pfam03345
710685005825	Cupin domain; Region: Cupin_2; cl09118
710685005826	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
710685005827	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005828	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
710685005829	Helix-turn-helix domains; Region: HTH; cl00088
710685005830	Permease; Region: Permease; cl00510
710685005831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
710685005832	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
710685005833	Putative cyclase; Region: Cyclase; cl00814
710685005834	Uncharacterized conserved protein [Function unknown]; Region: COG2006
710685005835	Domain of unknown function (DUF362); Region: DUF362; pfam04015
710685005836	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
710685005837	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
710685005838	chorismate binding enzyme; Region: Chorismate_bind; cl10555
710685005839	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
710685005840	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
710685005841	glutamine binding [chemical binding]; other site
710685005842	catalytic triad [active]
710685005843	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
710685005844	Ligand Binding Site [chemical binding]; other site
710685005845	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685005846	AIR carboxylase; Region: AIRC; cl00310
710685005847	Protein of unknown function DUF111; Region: DUF111; cl03398
710685005848	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
710685005849	AMP-binding enzyme; Region: AMP-binding; cl15778
710685005850	NeuB family; Region: NeuB; cl00496
710685005851	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005852	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
710685005853	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
710685005854	tetramer interface [polypeptide binding]; other site
710685005855	active site
710685005856	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
710685005857	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
710685005858	homodimer interface [polypeptide binding]; other site
710685005859	substrate-cofactor binding pocket; other site
710685005860	catalytic residue [active]
710685005861	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
710685005862	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
710685005863	argininosuccinate lyase; Provisional; Region: PRK02186
710685005864	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685005865	hypothetical protein; Provisional; Region: PRK07206
710685005866	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685005867	HNH endonuclease; Region: HNH_3; pfam13392
710685005868	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685005869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685005870	active site
710685005871	phosphorylation site [posttranslational modification]
710685005872	intermolecular recognition site; other site
710685005873	dimerization interface [polypeptide binding]; other site
710685005874	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685005875	DNA binding site [nucleotide binding]
710685005876	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
710685005877	dimerization interface [polypeptide binding]; other site
710685005878	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685005879	dimer interface [polypeptide binding]; other site
710685005880	phosphorylation site [posttranslational modification]
710685005881	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
710685005882	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685005883	ATP binding site [chemical binding]; other site
710685005884	Mg2+ binding site [ion binding]; other site
710685005885	G-X-G motif; other site
710685005886	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
710685005887	nucleotide binding site/active site [active]
710685005888	HIT family signature motif; other site
710685005889	catalytic residue [active]
710685005890	classical (c) SDRs; Region: SDR_c; cd05233
710685005891	active site
710685005892	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685005893	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
710685005894	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
710685005895	NAD binding site [chemical binding]; other site
710685005896	catalytic Zn binding site [ion binding]; other site
710685005897	substrate binding site [chemical binding]; other site
710685005898	structural Zn binding site [ion binding]; other site
710685005899	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
710685005900	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
710685005901	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685005902	Cytochrome P450; Region: p450; pfam00067
710685005903	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
710685005904	classical (c) SDRs; Region: SDR_c; cd05233
710685005905	NAD(P) binding site [chemical binding]; other site
710685005906	active site
710685005907	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685005908	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685005909	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
710685005910	NAD binding site [chemical binding]; other site
710685005911	catalytic residues [active]
710685005912	classical (c) SDRs; Region: SDR_c; cd05233
710685005913	NAD(P) binding site [chemical binding]; other site
710685005914	active site
710685005915	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
710685005916	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005917	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685005918	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685005919	Predicted membrane protein [Function unknown]; Region: COG4270
710685005920	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685005921	Helix-turn-helix domains; Region: HTH; cl00088
710685005922	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685005923	Helix-turn-helix domains; Region: HTH; cl00088
710685005924	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685005925	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
710685005926	Amidinotransferase; Region: Amidinotransf; cl12043
710685005927	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
710685005928	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
710685005929	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685005930	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
710685005931	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
710685005932	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
710685005933	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005934	NAD(P) binding site [chemical binding]; other site
710685005935	active site
710685005936	amino acid transporter; Region: 2A0306; TIGR00909
710685005937	Spore germination protein; Region: Spore_permease; cl15802
710685005938	Protein of unknown function (DUF429); Region: DUF429; cl12046
710685005939	adenylosuccinate lyase; Region: purB; TIGR00928
710685005940	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
710685005941	tetramer interface [polypeptide binding]; other site
710685005942	active site
710685005943	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685005944	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
710685005945	gating phenylalanine in ion channel; other site
710685005946	Proteins of 100 residues with WXG; Region: WXG100; cl02005
710685005947	trehalose synthase; Region: treS_nterm; TIGR02456
710685005948	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
710685005949	active site
710685005950	catalytic site [active]
710685005951	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286
710685005952	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685005953	Helix-turn-helix domains; Region: HTH; cl00088
710685005954	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
710685005955	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
710685005956	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
710685005957	active site
710685005958	catalytic site [active]
710685005959	enoyl-CoA hydratase; Provisional; Region: PRK08260
710685005960	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685005961	substrate binding site [chemical binding]; other site
710685005962	oxyanion hole (OAH) forming residues; other site
710685005963	trimer interface [polypeptide binding]; other site
710685005964	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
710685005965	Isochorismatase family; Region: Isochorismatase; pfam00857
710685005966	catalytic triad [active]
710685005967	metal binding site [ion binding]; metal-binding site
710685005968	conserved cis-peptide bond; other site
710685005969	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
710685005970	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
710685005971	NAD binding site [chemical binding]; other site
710685005972	catalytic Zn binding site [ion binding]; other site
710685005973	structural Zn binding site [ion binding]; other site
710685005974	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685005975	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685005976	active site
710685005977	Flavin Reductases; Region: FlaRed; cl00801
710685005978	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685005979	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
710685005980	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
710685005981	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
710685005982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685005983	S-adenosylmethionine binding site [chemical binding]; other site
710685005984	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
710685005985	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685005986	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685005987	Helix-turn-helix domains; Region: HTH; cl00088
710685005988	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685005989	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685005990	Cytochrome P450; Region: p450; pfam00067
710685005991	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685005992	CoenzymeA binding site [chemical binding]; other site
710685005993	subunit interaction site [polypeptide binding]; other site
710685005994	PHB binding site; other site
710685005995	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
710685005996	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
710685005997	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
710685005998	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685005999	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
710685006000	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006001	NAD(P) binding site [chemical binding]; other site
710685006002	active site
710685006003	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685006004	Predicted ATPase [General function prediction only]; Region: COG3899
710685006005	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685006006	DNA binding residues [nucleotide binding]
710685006007	dimerization interface [polypeptide binding]; other site
710685006008	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685006009	classical (c) SDRs; Region: SDR_c; cd05233
710685006010	NAD(P) binding site [chemical binding]; other site
710685006011	active site
710685006012	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
710685006013	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685006014	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685006015	DNA binding residues [nucleotide binding]
710685006016	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685006017	Leucine carboxyl methyltransferase; Region: LCM; cl01306
710685006018	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685006019	substrate binding site [chemical binding]; other site
710685006020	oxyanion hole (OAH) forming residues; other site
710685006021	trimer interface [polypeptide binding]; other site
710685006022	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685006023	phosphopeptide binding site; other site
710685006024	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685006025	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685006026	active site
710685006027	ATP binding site [chemical binding]; other site
710685006028	substrate binding site [chemical binding]; other site
710685006029	activation loop (A-loop); other site
710685006030	PknH-like extracellular domain; Region: PknH_C; pfam14032
710685006031	PknH-like extracellular domain; Region: PknH_C; pfam14032
710685006032	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006033	FAD dependent oxidoreductase; Region: DAO; pfam01266
710685006034	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
710685006035	hydrophobic ligand binding site; other site
710685006036	Domain of unknown function (DUF427); Region: DUF427; cl00998
710685006037	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
710685006038	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
710685006039	minor groove reading motif; other site
710685006040	helix-hairpin-helix signature motif; other site
710685006041	active site
710685006042	Ferritin-like domain; Region: Ferritin; pfam00210
710685006043	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
710685006044	dimerization interface [polypeptide binding]; other site
710685006045	DPS ferroxidase diiron center [ion binding]; other site
710685006046	ion pore; other site
710685006047	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
710685006048	amphipathic channel; other site
710685006049	Asn-Pro-Ala signature motifs; other site
710685006050	Cupin domain; Region: Cupin_2; cl09118
710685006051	Cupin domain; Region: Cupin_2; cl09118
710685006052	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685006053	CoenzymeA binding site [chemical binding]; other site
710685006054	subunit interaction site [polypeptide binding]; other site
710685006055	PHB binding site; other site
710685006056	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
710685006057	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
710685006058	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685006059	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
710685006060	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
710685006061	active site
710685006062	dimer interface [polypeptide binding]; other site
710685006063	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
710685006064	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
710685006065	active site
710685006066	FMN binding site [chemical binding]; other site
710685006067	substrate binding site [chemical binding]; other site
710685006068	3Fe-4S cluster binding site [ion binding]; other site
710685006069	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
710685006070	domain interface; other site
710685006071	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
710685006072	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006073	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
710685006074	ATP binding site [chemical binding]; other site
710685006075	active site
710685006076	substrate binding site [chemical binding]; other site
710685006077	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
710685006078	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685006079	Helix-turn-helix domains; Region: HTH; cl00088
710685006080	WHG domain; Region: WHG; pfam13305
710685006081	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
710685006082	catalytic residues [active]
710685006083	dimer interface [polypeptide binding]; other site
710685006084	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
710685006085	Predicted deacetylase [General function prediction only]; Region: COG3233
710685006086	putative active site [active]
710685006087	putative Zn binding site [ion binding]; other site
710685006088	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
710685006089	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685006090	Transposase, Mutator family; Region: Transposase_mut; pfam00872
710685006091	MULE transposase domain; Region: MULE; pfam10551
710685006092	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
710685006093	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
710685006094	putative active site [active]
710685006095	catalytic triad [active]
710685006096	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
710685006097	Helix-turn-helix domains; Region: HTH; cl00088
710685006098	Integrase core domain; Region: rve; cl01316
710685006099	Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659
710685006100	Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047
710685006101	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
710685006102	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
710685006103	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
710685006104	active site
710685006105	metal binding site [ion binding]; metal-binding site
710685006106	yybP-ykoY leader
710685006107	Helix-turn-helix domains; Region: HTH; cl00088
710685006108	putative Zn2+ binding site [ion binding]; other site
710685006109	putative DNA binding site [nucleotide binding]; other site
710685006110	yybP-ykoY leader
710685006111	Integral membrane protein TerC family; Region: TerC; cl10468
710685006112	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685006113	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
710685006114	active site
710685006115	metal binding site [ion binding]; metal-binding site
710685006116	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
710685006117	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
710685006118	dimerization interface [polypeptide binding]; other site
710685006119	ATP binding site [chemical binding]; other site
710685006120	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
710685006121	dimerization interface [polypeptide binding]; other site
710685006122	ATP binding site [chemical binding]; other site
710685006123	Predicted membrane protein [Function unknown]; Region: COG4425
710685006124	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
710685006125	CAAX protease self-immunity; Region: Abi; cl00558
710685006126	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685006127	classical (c) SDRs; Region: SDR_c; cd05233
710685006128	NAD(P) binding site [chemical binding]; other site
710685006129	active site
710685006130	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685006131	mce related protein; Region: MCE; pfam02470
710685006132	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685006133	amidophosphoribosyltransferase; Provisional; Region: PRK07847
710685006134	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
710685006135	active site
710685006136	tetramer interface [polypeptide binding]; other site
710685006137	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
710685006138	active site
710685006139	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
710685006140	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
710685006141	putative NAD(P) binding site [chemical binding]; other site
710685006142	putative active site [active]
710685006143	Cupin domain; Region: Cupin_2; cl09118
710685006144	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
710685006145	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
710685006146	dimerization interface [polypeptide binding]; other site
710685006147	putative ATP binding site [chemical binding]; other site
710685006148	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
710685006149	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
710685006150	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
710685006151	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
710685006152	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
710685006153	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685006154	catalytic residue [active]
710685006155	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
710685006156	ligand binding site [chemical binding]; other site
710685006157	flexible hinge region; other site
710685006158	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
710685006159	ligand binding site [chemical binding]; other site
710685006160	flexible hinge region; other site
710685006161	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
710685006162	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418
710685006163	putative active site [active]
710685006164	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
710685006165	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685006166	Walker A/P-loop; other site
710685006167	ATP binding site [chemical binding]; other site
710685006168	Q-loop/lid; other site
710685006169	ABC transporter signature motif; other site
710685006170	Walker B; other site
710685006171	D-loop; other site
710685006172	H-loop/switch region; other site
710685006173	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685006174	phosphopeptide binding site; other site
710685006175	cyclase homology domain; Region: CHD; cd07302
710685006176	nucleotidyl binding site; other site
710685006177	metal binding site [ion binding]; metal-binding site
710685006178	dimer interface [polypeptide binding]; other site
710685006179	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
710685006180	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685006181	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685006182	active site
710685006183	DNA binding site [nucleotide binding]
710685006184	Int/Topo IB signature motif; other site
710685006185	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
710685006186	Recombinase; Region: Recombinase; pfam07508
710685006187	AAA domain; Region: AAA_25; pfam13481
710685006188	Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741
710685006189	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
710685006190	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
710685006191	substrate binding pocket [chemical binding]; other site
710685006192	membrane-bound complex binding site; other site
710685006193	hinge residues; other site
710685006194	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
710685006195	heme-binding site [chemical binding]; other site
710685006196	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
710685006197	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
710685006198	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
710685006199	active site residue [active]
710685006200	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
710685006201	active site residue [active]
710685006202	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
710685006203	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
710685006204	catalytic residues [active]
710685006205	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
710685006206	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685006207	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685006208	DNA binding site [nucleotide binding]
710685006209	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
710685006210	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685006211	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685006212	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685006213	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
710685006214	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685006215	dimer interface [polypeptide binding]; other site
710685006216	conserved gate region; other site
710685006217	putative PBP binding loops; other site
710685006218	ABC-ATPase subunit interface; other site
710685006219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685006220	dimer interface [polypeptide binding]; other site
710685006221	conserved gate region; other site
710685006222	putative PBP binding loops; other site
710685006223	ABC-ATPase subunit interface; other site
710685006224	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
710685006225	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
710685006226	Walker A/P-loop; other site
710685006227	ATP binding site [chemical binding]; other site
710685006228	Q-loop/lid; other site
710685006229	ABC transporter signature motif; other site
710685006230	Walker B; other site
710685006231	D-loop; other site
710685006232	H-loop/switch region; other site
710685006233	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
710685006234	PhoU domain; Region: PhoU; pfam01895
710685006235	PhoU domain; Region: PhoU; pfam01895
710685006236	transcriptional regulator ICP4; Provisional; Region: PHA03307
710685006237	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
710685006238	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
710685006239	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
710685006240	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
710685006241	FMN binding site [chemical binding]; other site
710685006242	active site
710685006243	catalytic residues [active]
710685006244	substrate binding site [chemical binding]; other site
710685006245	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
710685006246	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
710685006247	homodimer interface [polypeptide binding]; other site
710685006248	putative substrate binding pocket [chemical binding]; other site
710685006249	diiron center [ion binding]; other site
710685006250	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685006251	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
710685006252	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
710685006253	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
710685006254	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685006255	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006256	short chain dehydrogenase; Provisional; Region: PRK07832
710685006257	NAD(P) binding site [chemical binding]; other site
710685006258	active site
710685006259	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
710685006260	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006261	NAD(P) binding site [chemical binding]; other site
710685006262	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685006263	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685006264	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
710685006265	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
710685006266	Helix-turn-helix domains; Region: HTH; cl00088
710685006267	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
710685006268	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006269	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685006270	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685006271	active site
710685006272	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
710685006273	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
710685006274	putative NAD(P) binding site [chemical binding]; other site
710685006275	active site
710685006276	putative substrate binding site [chemical binding]; other site
710685006277	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957
710685006278	Permease; Region: Permease; cl00510
710685006279	Permease; Region: Permease; cl00510
710685006280	mce related protein; Region: MCE; pfam02470
710685006281	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685006282	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685006283	mce related protein; Region: MCE; pfam02470
710685006284	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685006285	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685006286	mce related protein; Region: MCE; pfam02470
710685006287	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685006288	mce related protein; Region: MCE; pfam02470
710685006289	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685006290	mce related protein; Region: MCE; pfam02470
710685006291	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685006292	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685006293	mce related protein; Region: MCE; pfam02470
710685006294	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685006295	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
710685006296	putative hydrophobic ligand binding site [chemical binding]; other site
710685006297	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
710685006298	putative hydrophobic ligand binding site [chemical binding]; other site
710685006299	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
710685006300	putative hydrophobic ligand binding site [chemical binding]; other site
710685006301	Cation efflux family; Region: Cation_efflux; cl00316
710685006302	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685006303	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685006304	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
710685006305	putative hydrophobic ligand binding site [chemical binding]; other site
710685006306	aminotransferase; Validated; Region: PRK07777
710685006307	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
710685006308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685006309	homodimer interface [polypeptide binding]; other site
710685006310	catalytic residue [active]
710685006311	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
710685006312	FMN binding site [chemical binding]; other site
710685006313	active site
710685006314	substrate binding site [chemical binding]; other site
710685006315	catalytic residue [active]
710685006316	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
710685006317	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
710685006318	dimer interface [polypeptide binding]; other site
710685006319	active site
710685006320	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
710685006321	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685006322	substrate binding site [chemical binding]; other site
710685006323	oxyanion hole (OAH) forming residues; other site
710685006324	trimer interface [polypeptide binding]; other site
710685006325	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006326	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
710685006327	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
710685006328	AMP-binding enzyme; Region: AMP-binding; cl15778
710685006329	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685006330	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
710685006331	Amidase; Region: Amidase; cl11426
710685006332	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685006333	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
710685006334	Cupin domain; Region: Cupin_2; cl09118
710685006335	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
710685006336	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
710685006337	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685006338	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
710685006339	ATP binding site [chemical binding]; other site
710685006340	putative Mg++ binding site [ion binding]; other site
710685006341	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685006342	nucleotide binding region [chemical binding]; other site
710685006343	ATP-binding site [chemical binding]; other site
710685006344	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
710685006345	WYL domain; Region: WYL; cl14852
710685006346	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
710685006347	trimer interface [polypeptide binding]; other site
710685006348	dimer interface [polypeptide binding]; other site
710685006349	putative active site [active]
710685006350	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
710685006351	MPT binding site; other site
710685006352	trimer interface [polypeptide binding]; other site
710685006353	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399
710685006354	MoaD interaction [polypeptide binding]; other site
710685006355	active site residues [active]
710685006356	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
710685006357	Ubiquitin-like proteins; Region: UBQ; cl00155
710685006358	charged pocket; other site
710685006359	hydrophobic patch; other site
710685006360	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
710685006361	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
710685006362	FeS/SAM binding site; other site
710685006363	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
710685006364	hypothetical protein; Provisional; Region: PRK11770
710685006365	Domain of unknown function (DUF307); Region: DUF307; pfam03733
710685006366	Domain of unknown function (DUF307); Region: DUF307; pfam03733
710685006367	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
710685006368	DNA-binding site [nucleotide binding]; DNA binding site
710685006369	RNA-binding motif; other site
710685006370	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
710685006371	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
710685006372	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
710685006373	putative dimer interface [polypeptide binding]; other site
710685006374	N-terminal domain interface [polypeptide binding]; other site
710685006375	putative substrate binding pocket (H-site) [chemical binding]; other site
710685006376	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
710685006377	H+ Antiporter protein; Region: 2A0121; TIGR00900
710685006378	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
710685006379	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
710685006380	hydrophobic ligand binding site; other site
710685006381	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
710685006382	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
710685006383	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
710685006384	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
710685006385	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
710685006386	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
710685006387	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
710685006388	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
710685006389	catalytic residue [active]
710685006390	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
710685006391	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
710685006392	active site
710685006393	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
710685006394	Ferredoxin [Energy production and conversion]; Region: COG1146
710685006395	4Fe-4S binding domain; Region: Fer4; cl02805
710685006396	ferredoxin-NADP+ reductase; Region: PLN02852
710685006397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006398	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
710685006399	putative dimer interface [polypeptide binding]; other site
710685006400	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685006401	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
710685006402	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
710685006403	active site
710685006404	catalytic residues [active]
710685006405	TIGR03086 family protein; Region: TIGR03086
710685006406	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
710685006407	dimer interface [polypeptide binding]; other site
710685006408	Citrate synthase; Region: Citrate_synt; pfam00285
710685006409	active site
710685006410	citrylCoA binding site [chemical binding]; other site
710685006411	oxalacetate/citrate binding site [chemical binding]; other site
710685006412	coenzyme A binding site [chemical binding]; other site
710685006413	catalytic triad [active]
710685006414	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
710685006415	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685006416	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
710685006417	enterobactin exporter EntS; Provisional; Region: PRK10489
710685006418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
710685006419	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
710685006420	Helix-turn-helix domains; Region: HTH; cl00088
710685006421	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
710685006422	dimer interface [polypeptide binding]; other site
710685006423	Citrate synthase; Region: Citrate_synt; pfam00285
710685006424	active site
710685006425	citrylCoA binding site [chemical binding]; other site
710685006426	NADH binding [chemical binding]; other site
710685006427	cationic pore residues; other site
710685006428	oxalacetate/citrate binding site [chemical binding]; other site
710685006429	coenzyme A binding site [chemical binding]; other site
710685006430	catalytic triad [active]
710685006431	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
710685006432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685006433	putative substrate translocation pore; other site
710685006434	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
710685006435	Helix-turn-helix domains; Region: HTH; cl00088
710685006436	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
710685006437	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006438	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
710685006439	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
710685006440	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
710685006441	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685006442	dimer interface [polypeptide binding]; other site
710685006443	phosphorylation site [posttranslational modification]
710685006444	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685006445	ATP binding site [chemical binding]; other site
710685006446	Mg2+ binding site [ion binding]; other site
710685006447	G-X-G motif; other site
710685006448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685006449	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685006450	active site
710685006451	phosphorylation site [posttranslational modification]
710685006452	intermolecular recognition site; other site
710685006453	dimerization interface [polypeptide binding]; other site
710685006454	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685006455	DNA binding site [nucleotide binding]
710685006456	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127
710685006457	PLD-like domain; Region: PLDc_2; pfam13091
710685006458	putative active site [active]
710685006459	putative catalytic site [active]
710685006460	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128
710685006461	PLD-like domain; Region: PLDc_2; pfam13091
710685006462	putative active site [active]
710685006463	putative catalytic site [active]
710685006464	Chromate transporter; Region: Chromate_transp; pfam02417
710685006465	Chromate transporter; Region: Chromate_transp; pfam02417
710685006466	Polycystin cation channel; Region: PKD_channel; pfam08016
710685006467	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
710685006468	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
710685006469	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685006470	Walker A/P-loop; other site
710685006471	ATP binding site [chemical binding]; other site
710685006472	Q-loop/lid; other site
710685006473	ABC transporter signature motif; other site
710685006474	Walker B; other site
710685006475	D-loop; other site
710685006476	H-loop/switch region; other site
710685006477	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
710685006478	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
710685006479	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685006480	Walker A/P-loop; other site
710685006481	ATP binding site [chemical binding]; other site
710685006482	Q-loop/lid; other site
710685006483	ABC transporter signature motif; other site
710685006484	Walker B; other site
710685006485	D-loop; other site
710685006486	H-loop/switch region; other site
710685006487	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
710685006488	Epoxide hydrolase N terminus; Region: EHN; pfam06441
710685006489	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685006490	AMP-binding domain protein; Validated; Region: PRK08315
710685006491	AMP-binding enzyme; Region: AMP-binding; cl15778
710685006492	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685006493	FAD binding domain; Region: FAD_binding_3; pfam01494
710685006494	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006495	Helix-turn-helix domains; Region: HTH; cl00088
710685006496	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
710685006497	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685006498	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685006499	enoyl-CoA hydratase; Provisional; Region: PRK06688
710685006500	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685006501	substrate binding site [chemical binding]; other site
710685006502	oxyanion hole (OAH) forming residues; other site
710685006503	trimer interface [polypeptide binding]; other site
710685006504	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685006505	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685006506	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
710685006507	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
710685006508	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
710685006509	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685006510	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
710685006511	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
710685006512	hydrophobic ligand binding site; other site
710685006513	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
710685006514	dimer interface [polypeptide binding]; other site
710685006515	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685006516	ligand binding site [chemical binding]; other site
710685006517	ERG2 and Sigma1 receptor like protein; Region: ERG2_Sigma1R; pfam04622
710685006518	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685006519	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685006520	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006521	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685006522	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685006523	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
710685006524	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685006525	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
710685006526	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
710685006527	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685006528	metal ion-dependent adhesion site (MIDAS); other site
710685006529	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685006530	Helix-turn-helix domains; Region: HTH; cl00088
710685006531	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685006532	Helix-turn-helix domains; Region: HTH; cl00088
710685006533	short chain dehydrogenase; Provisional; Region: PRK07814
710685006534	classical (c) SDRs; Region: SDR_c; cd05233
710685006535	NAD(P) binding site [chemical binding]; other site
710685006536	active site
710685006537	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685006538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006539	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006540	NAD(P) binding site [chemical binding]; other site
710685006541	active site
710685006542	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
710685006543	AMP-binding enzyme; Region: AMP-binding; cl15778
710685006544	AMP-binding enzyme; Region: AMP-binding; cl15778
710685006545	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
710685006546	classical (c) SDRs; Region: SDR_c; cd05233
710685006547	NAD(P) binding site [chemical binding]; other site
710685006548	active site
710685006549	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
710685006550	AMP-binding enzyme; Region: AMP-binding; cl15778
710685006551	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
710685006552	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685006553	DNA-binding site [nucleotide binding]; DNA binding site
710685006554	UTRA domain; Region: UTRA; cl01230
710685006555	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
710685006556	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
710685006557	PQQ-like domain; Region: PQQ_2; pfam13360
710685006558	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
710685006559	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
710685006560	classical (c) SDRs; Region: SDR_c; cd05233
710685006561	NAD(P) binding site [chemical binding]; other site
710685006562	active site
710685006563	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685006564	[2Fe-2S] cluster binding site [ion binding]; other site
710685006565	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685006566	hydrophobic ligand binding site; other site
710685006567	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685006568	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006569	NAD(P) binding site [chemical binding]; other site
710685006570	active site
710685006571	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685006572	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685006573	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685006574	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
710685006575	active site
710685006576	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685006577	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
710685006578	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006579	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
710685006580	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
710685006581	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685006582	active site
710685006583	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685006584	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685006585	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685006586	active site
710685006587	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
710685006588	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
710685006589	PYR/PP interface [polypeptide binding]; other site
710685006590	dimer interface [polypeptide binding]; other site
710685006591	TPP binding site [chemical binding]; other site
710685006592	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
710685006593	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
710685006594	TPP-binding site; other site
710685006595	dimer interface [polypeptide binding]; other site
710685006596	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
710685006597	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685006598	NAD binding site [chemical binding]; other site
710685006599	catalytic residues [active]
710685006600	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
710685006601	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
710685006602	active site
710685006603	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
710685006604	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685006605	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
710685006606	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006607	NAD(P) binding site [chemical binding]; other site
710685006608	active site
710685006609	Integrase core domain; Region: rve; cl01316
710685006610	Integrase core domain; Region: rve_3; cl15866
710685006611	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
710685006612	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685006613	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
710685006614	TniQ; Region: TniQ; pfam06527
710685006615	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
710685006616	non-specific DNA binding site [nucleotide binding]; other site
710685006617	salt bridge; other site
710685006618	sequence-specific DNA binding site [nucleotide binding]; other site
710685006619	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
710685006620	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
710685006621	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006622	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
710685006623	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
710685006624	metal-binding site [ion binding]
710685006625	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
710685006626	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
710685006627	metal-binding site [ion binding]
710685006628	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006629	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
710685006630	Helix-turn-helix domains; Region: HTH; cl00088
710685006631	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
710685006632	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685006633	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
710685006634	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
710685006635	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
710685006636	NlpC/P60 family; Region: NLPC_P60; cl11438
710685006637	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685006638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685006639	active site
710685006640	phosphorylation site [posttranslational modification]
710685006641	intermolecular recognition site; other site
710685006642	dimerization interface [polypeptide binding]; other site
710685006643	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685006644	DNA binding site [nucleotide binding]
710685006645	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
710685006646	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
710685006647	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
710685006648	DNA binding residues [nucleotide binding]
710685006649	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
710685006650	cyclase homology domain; Region: CHD; cd07302
710685006651	nucleotidyl binding site; other site
710685006652	metal binding site [ion binding]; metal-binding site
710685006653	dimer interface [polypeptide binding]; other site
710685006654	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
710685006655	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
710685006656	Bacterial Ig-like domain; Region: Big_5; cl01012
710685006657	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
710685006658	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
710685006659	NlpC/P60 family; Region: NLPC_P60; cl11438
710685006660	NlpC/P60 family; Region: NLPC_P60; cl11438
710685006661	Domain of unknown function (DUF305); Region: DUF305; cl15795
710685006662	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685006663	dimer interface [polypeptide binding]; other site
710685006664	phosphorylation site [posttranslational modification]
710685006665	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685006666	ATP binding site [chemical binding]; other site
710685006667	Mg2+ binding site [ion binding]; other site
710685006668	G-X-G motif; other site
710685006669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685006670	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
710685006671	active site
710685006672	phosphorylation site [posttranslational modification]
710685006673	intermolecular recognition site; other site
710685006674	dimerization interface [polypeptide binding]; other site
710685006675	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685006676	DNA binding site [nucleotide binding]
710685006677	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
710685006678	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
710685006679	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
710685006680	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
710685006681	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
710685006682	NlpC/P60 family; Region: NLPC_P60; cl11438
710685006683	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
710685006684	catalytic residues [active]
710685006685	Helix-turn-helix domains; Region: HTH; cl00088
710685006686	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
710685006687	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
710685006688	Helix-turn-helix domains; Region: HTH; cl00088
710685006689	Peptidase family M48; Region: Peptidase_M48; cl12018
710685006690	Predicted esterase [General function prediction only]; Region: COG0627
710685006691	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685006692	Peptidase family M23; Region: Peptidase_M23; pfam01551
710685006693	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
710685006694	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
710685006695	putative active site [active]
710685006696	catalytic triad [active]
710685006697	putative dimer interface [polypeptide binding]; other site
710685006698	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685006699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685006700	active site
710685006701	phosphorylation site [posttranslational modification]
710685006702	intermolecular recognition site; other site
710685006703	dimerization interface [polypeptide binding]; other site
710685006704	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685006705	DNA binding site [nucleotide binding]
710685006706	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
710685006707	Cupin domain; Region: Cupin_2; cl09118
710685006708	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
710685006709	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
710685006710	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
710685006711	dimer interface [polypeptide binding]; other site
710685006712	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685006713	catalytic residue [active]
710685006714	multidrug resistance protein MdtH; Provisional; Region: PRK11646
710685006715	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
710685006716	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
710685006717	dimerization interface [polypeptide binding]; other site
710685006718	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
710685006719	putative homodimer interface [polypeptide binding]; other site
710685006720	putative homotetramer interface [polypeptide binding]; other site
710685006721	putative allosteric switch controlling residues; other site
710685006722	putative metal binding site [ion binding]; other site
710685006723	putative homodimer-homodimer interface [polypeptide binding]; other site
710685006724	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
710685006725	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
710685006726	metal-binding site [ion binding]
710685006727	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
710685006728	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685006729	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
710685006730	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
710685006731	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
710685006732	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685006733	Domain of unknown function (DUF305); Region: DUF305; cl15795
710685006734	Domain of unknown function (DUF305); Region: DUF305; cl15795
710685006735	Short C-terminal domain; Region: SHOCT; cl01373
710685006736	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
710685006737	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
710685006738	active site residue [active]
710685006739	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
710685006740	active site residue [active]
710685006741	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
710685006742	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
710685006743	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
710685006744	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
710685006745	active site
710685006746	ATP binding site [chemical binding]; other site
710685006747	Predicted integral membrane protein [Function unknown]; Region: COG0392
710685006748	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
710685006749	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685006750	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
710685006751	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
710685006752	metal-binding site [ion binding]
710685006753	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
710685006754	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
710685006755	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685006756	putative phosphoketolase; Provisional; Region: PRK05261
710685006757	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
710685006758	TPP-binding site; other site
710685006759	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
710685006760	XFP C-terminal domain; Region: XFP_C; pfam09363
710685006761	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
710685006762	putative homodimer interface [polypeptide binding]; other site
710685006763	putative homotetramer interface [polypeptide binding]; other site
710685006764	putative allosteric switch controlling residues; other site
710685006765	putative metal binding site [ion binding]; other site
710685006766	putative homodimer-homodimer interface [polypeptide binding]; other site
710685006767	copper exporting ATPase; Provisional; Region: copA; PRK10671
710685006768	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
710685006769	metal-binding site [ion binding]
710685006770	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
710685006771	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
710685006772	metal-binding site [ion binding]
710685006773	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
710685006774	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685006775	S-adenosylmethionine binding site [chemical binding]; other site
710685006776	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
710685006777	active site
710685006778	catalytic triad [active]
710685006779	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
710685006780	putative active site [active]
710685006781	putative CoA binding site [chemical binding]; other site
710685006782	nudix motif; other site
710685006783	metal binding site [ion binding]; metal-binding site
710685006784	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
710685006785	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685006786	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
710685006787	active site
710685006788	ATP binding site [chemical binding]; other site
710685006789	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
710685006790	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685006791	motif II; other site
710685006792	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
710685006793	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
710685006794	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
710685006795	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
710685006796	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
710685006797	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
710685006798	Phospholipid methyltransferase; Region: PEMT; cl00763
710685006799	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
710685006800	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006801	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
710685006802	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685006803	Walker A/P-loop; other site
710685006804	ATP binding site [chemical binding]; other site
710685006805	Q-loop/lid; other site
710685006806	ABC transporter signature motif; other site
710685006807	Walker B; other site
710685006808	D-loop; other site
710685006809	H-loop/switch region; other site
710685006810	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
710685006811	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
710685006812	catalytic residues [active]
710685006813	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006814	Bacterial Ig-like domain; Region: Big_5; cl01012
710685006815	Helix-turn-helix domains; Region: HTH; cl00088
710685006816	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
710685006817	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685006818	Helix-turn-helix domains; Region: HTH; cl00088
710685006819	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
710685006820	NlpC/P60 family; Region: NLPC_P60; cl11438
710685006821	VirB8 protein; Region: VirB8; cl01500
710685006822	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685006823	dimerization interface [polypeptide binding]; other site
710685006824	putative DNA binding site [nucleotide binding]; other site
710685006825	putative Zn2+ binding site [ion binding]; other site
710685006826	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
710685006827	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685006828	putative metal binding site [ion binding]; other site
710685006829	DinB superfamily; Region: DinB_2; pfam12867
710685006830	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685006831	dimerization interface [polypeptide binding]; other site
710685006832	putative DNA binding site [nucleotide binding]; other site
710685006833	putative Zn2+ binding site [ion binding]; other site
710685006834	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
710685006835	amphipathic channel; other site
710685006836	Asn-Pro-Ala signature motifs; other site
710685006837	Low molecular weight phosphatase family; Region: LMWPc; cd00115
710685006838	active site
710685006839	Low molecular weight phosphatase family; Region: LMWPc; cd00115
710685006840	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
710685006841	active site
710685006842	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
710685006843	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
710685006844	DNA binding residues [nucleotide binding]
710685006845	dimer interface [polypeptide binding]; other site
710685006846	mercury binding site [ion binding]; other site
710685006847	Alkylmercury lyase; Region: MerB; pfam03243
710685006848	Fic/DOC family; Region: Fic; cl00960
710685006849	Divergent AAA domain; Region: AAA_4; pfam04326
710685006850	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
710685006851	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
710685006852	Active Sites [active]
710685006853	TniQ; Region: TniQ; pfam06527
710685006854	Short C-terminal domain; Region: SHOCT; cl01373
710685006855	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
710685006856	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
710685006857	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685006858	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685006859	dimerization interface [polypeptide binding]; other site
710685006860	putative DNA binding site [nucleotide binding]; other site
710685006861	putative Zn2+ binding site [ion binding]; other site
710685006862	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
710685006863	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
710685006864	active site
710685006865	DNA binding site [nucleotide binding]
710685006866	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
710685006867	DNA binding site [nucleotide binding]
710685006868	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
710685006869	active site
710685006870	catalytic residues [active]
710685006871	DNA binding site [nucleotide binding]
710685006872	Int/Topo IB signature motif; other site
710685006873	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
710685006874	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685006875	active site
710685006876	DNA binding site [nucleotide binding]
710685006877	Int/Topo IB signature motif; other site
710685006878	AAA domain; Region: AAA_22; pfam13401
710685006879	TniQ; Region: TniQ; pfam06527
710685006880	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
710685006881	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
710685006882	tetramer interface [polypeptide binding]; other site
710685006883	active site
710685006884	D-cysteine desulfhydrase; Validated; Region: PRK03910
710685006885	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
710685006886	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
710685006887	catalytic residue [active]
710685006888	argininosuccinate lyase; Region: argH; TIGR00838
710685006889	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
710685006890	tetramer interface [polypeptide binding]; other site
710685006891	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685006892	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
710685006893	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685006894	active site
710685006895	DNA binding site [nucleotide binding]
710685006896	Int/Topo IB signature motif; other site
710685006897	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
710685006898	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
710685006899	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685006900	active site
710685006901	DNA binding site [nucleotide binding]
710685006902	Int/Topo IB signature motif; other site
710685006903	Transposase, Mutator family; Region: Transposase_mut; pfam00872
710685006904	MULE transposase domain; Region: MULE; pfam10551
710685006905	Transposase, Mutator family; Region: Transposase_mut; pfam00872
710685006906	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685006907	active site
710685006908	DNA binding site [nucleotide binding]
710685006909	Int/Topo IB signature motif; other site
710685006910	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
710685006911	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
710685006912	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685006913	active site
710685006914	DNA binding site [nucleotide binding]
710685006915	Int/Topo IB signature motif; other site
710685006916	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
710685006917	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733
710685006918	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
710685006919	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
710685006920	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
710685006921	putative di-iron ligands [ion binding]; other site
710685006922	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
710685006923	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
710685006924	tetramer interface [polypeptide binding]; other site
710685006925	D-cysteine desulfhydrase; Validated; Region: PRK03910
710685006926	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
710685006927	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
710685006928	catalytic residue [active]
710685006929	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
710685006930	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
710685006931	tetramer interface [polypeptide binding]; other site
710685006932	active site
710685006933	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782
710685006934	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
710685006935	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685006936	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
710685006937	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006938	NAD(P) binding site [chemical binding]; other site
710685006939	active site
710685006940	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
710685006941	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685006942	dimer interface [polypeptide binding]; other site
710685006943	conserved gate region; other site
710685006944	putative PBP binding loops; other site
710685006945	ABC-ATPase subunit interface; other site
710685006946	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685006947	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
710685006948	Walker A/P-loop; other site
710685006949	ATP binding site [chemical binding]; other site
710685006950	Q-loop/lid; other site
710685006951	ABC transporter signature motif; other site
710685006952	Walker B; other site
710685006953	D-loop; other site
710685006954	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
710685006955	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
710685006956	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
710685006957	conserved cys residue [active]
710685006958	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
710685006959	Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609
710685006960	Transposase; Region: DDE_Tnp_ISL3; pfam01610
710685006961	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
710685006962	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
710685006963	substrate binding pocket [chemical binding]; other site
710685006964	membrane-bound complex binding site; other site
710685006965	hinge residues; other site
710685006966	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
710685006967	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
710685006968	Helix-turn-helix domains; Region: HTH; cl00088
710685006969	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
710685006970	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
710685006971	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
710685006972	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685006973	CoA-ligase; Region: Ligase_CoA; cl02894
710685006974	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685006975	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
710685006976	substrate binding site [chemical binding]; other site
710685006977	THF binding site; other site
710685006978	zinc-binding site [ion binding]; other site
710685006979	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
710685006980	dimerization interface [polypeptide binding]; other site
710685006981	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
710685006982	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
710685006983	dimerization interface [polypeptide binding]; other site
710685006984	putative path to active site cavity [active]
710685006985	diiron center [ion binding]; other site
710685006986	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685006987	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
710685006988	catalytic loop [active]
710685006989	iron binding site [ion binding]; other site
710685006990	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
710685006991	FAD binding pocket [chemical binding]; other site
710685006992	conserved FAD binding motif [chemical binding]; other site
710685006993	phosphate binding motif [ion binding]; other site
710685006994	beta-alpha-beta structure motif; other site
710685006995	NAD binding pocket [chemical binding]; other site
710685006996	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
710685006997	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
710685006998	classical (c) SDRs; Region: SDR_c; cd05233
710685006999	NAD(P) binding site [chemical binding]; other site
710685007000	active site
710685007001	Transcription factor WhiB; Region: Whib; pfam02467
710685007002	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685007003	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007004	active site
710685007005	DNA binding site [nucleotide binding]
710685007006	Int/Topo IB signature motif; other site
710685007007	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007008	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
710685007009	active site
710685007010	DNA binding site [nucleotide binding]
710685007011	Int/Topo IB signature motif; other site
710685007012	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685007013	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
710685007014	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
710685007015	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007016	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685007017	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007018	active site
710685007019	DNA binding site [nucleotide binding]
710685007020	Int/Topo IB signature motif; other site
710685007021	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
710685007022	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
710685007023	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007024	active site
710685007025	DNA binding site [nucleotide binding]
710685007026	Int/Topo IB signature motif; other site
710685007027	Transposase, Mutator family; Region: Transposase_mut; pfam00872
710685007028	MULE transposase domain; Region: MULE; pfam10551
710685007029	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
710685007030	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685007031	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
710685007032	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
710685007033	putative catalytic cysteine [active]
710685007034	Secretory lipase; Region: LIP; pfam03583
710685007035	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
710685007036	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
710685007037	putative di-iron ligands [ion binding]; other site
710685007038	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
710685007039	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
710685007040	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
710685007041	conserved cys residue [active]
710685007042	adenylate kinase; Reviewed; Region: adk; PRK00279
710685007043	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
710685007044	AMP-binding site [chemical binding]; other site
710685007045	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
710685007046	Permease; Region: Permease; cl00510
710685007047	Permease; Region: Permease; cl00510
710685007048	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
710685007049	mce related protein; Region: MCE; pfam02470
710685007050	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685007051	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007052	mce related protein; Region: MCE; pfam02470
710685007053	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685007054	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007055	mce related protein; Region: MCE; pfam02470
710685007056	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007057	mce related protein; Region: MCE; pfam02470
710685007058	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007059	mce related protein; Region: MCE; pfam02470
710685007060	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007061	mce related protein; Region: MCE; pfam02470
710685007062	RDD family; Region: RDD; cl00746
710685007063	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
710685007064	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685007065	NAD(P) binding site [chemical binding]; other site
710685007066	catalytic residues [active]
710685007067	Protein of unknown function (DUF779); Region: DUF779; cl01432
710685007068	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
710685007069	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685007070	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
710685007071	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
710685007072	catalytic Zn binding site [ion binding]; other site
710685007073	structural Zn binding site [ion binding]; other site
710685007074	NAD(P) binding site [chemical binding]; other site
710685007075	Transposase; Region: DEDD_Tnp_IS110; pfam01548
710685007076	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
710685007077	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
710685007078	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
710685007079	AMP-binding enzyme; Region: AMP-binding; cl15778
710685007080	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685007081	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
710685007082	apolar tunnel; other site
710685007083	heme binding site [chemical binding]; other site
710685007084	dimerization interface [polypeptide binding]; other site
710685007085	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
710685007086	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
710685007087	NAD binding site [chemical binding]; other site
710685007088	catalytic Zn binding site [ion binding]; other site
710685007089	substrate binding site [chemical binding]; other site
710685007090	structural Zn binding site [ion binding]; other site
710685007091	AMP-binding domain protein; Validated; Region: PRK08315
710685007092	AMP-binding enzyme; Region: AMP-binding; cl15778
710685007093	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685007094	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685007095	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685007096	active site
710685007097	putative acyltransferase; Provisional; Region: PRK05790
710685007098	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
710685007099	dimer interface [polypeptide binding]; other site
710685007100	active site
710685007101	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685007102	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685007103	substrate binding site [chemical binding]; other site
710685007104	oxyanion hole (OAH) forming residues; other site
710685007105	trimer interface [polypeptide binding]; other site
710685007106	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
710685007107	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007108	NAD(P) binding site [chemical binding]; other site
710685007109	active site
710685007110	RDD family; Region: RDD; cl00746
710685007111	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
710685007112	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685007113	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
710685007114	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685007115	Walker A motif; other site
710685007116	ATP binding site [chemical binding]; other site
710685007117	Walker B motif; other site
710685007118	arginine finger; other site
710685007119	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
710685007120	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
710685007121	active site
710685007122	NAD binding site [chemical binding]; other site
710685007123	metal binding site [ion binding]; metal-binding site
710685007124	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
710685007125	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685007126	Walker A motif; other site
710685007127	ATP binding site [chemical binding]; other site
710685007128	Walker B motif; other site
710685007129	arginine finger; other site
710685007130	Helix-turn-helix domains; Region: HTH; cl00088
710685007131	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
710685007132	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685007133	NAD(P) binding site [chemical binding]; other site
710685007134	catalytic residues [active]
710685007135	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
710685007136	AMP-binding enzyme; Region: AMP-binding; cl15778
710685007137	AMP-binding enzyme; Region: AMP-binding; cl15778
710685007138	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
710685007139	Helix-turn-helix domains; Region: HTH; cl00088
710685007140	RNA polymerase sigma factor; Provisional; Region: PRK12535
710685007141	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685007142	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685007143	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
710685007144	Predicted integral membrane protein [Function unknown]; Region: COG5660
710685007145	Putative zinc-finger; Region: zf-HC2; cl15806
710685007146	Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; cl04829
710685007147	Ammonia monooxygenase; Region: AMO; cl03602
710685007148	methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079
710685007149	Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744
710685007150	RDD family; Region: RDD; cl00746
710685007151	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
710685007152	Helix-turn-helix domains; Region: HTH; cl00088
710685007153	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
710685007154	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
710685007155	dinuclear metal binding motif [ion binding]; other site
710685007156	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
710685007157	dinuclear metal binding motif [ion binding]; other site
710685007158	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
710685007159	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
710685007160	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685007161	catalytic loop [active]
710685007162	iron binding site [ion binding]; other site
710685007163	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
710685007164	FAD binding pocket [chemical binding]; other site
710685007165	conserved FAD binding motif [chemical binding]; other site
710685007166	phosphate binding motif [ion binding]; other site
710685007167	beta-alpha-beta structure motif; other site
710685007168	NAD binding pocket [chemical binding]; other site
710685007169	Methane monooxygenase, hydrolase gamma chain; Region: MeMO_Hyd_G; pfam02964
710685007170	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
710685007171	Predicted integral membrane protein [Function unknown]; Region: COG5660
710685007172	Putative zinc-finger; Region: zf-HC2; cl15806
710685007173	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
710685007174	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
710685007175	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
710685007176	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
710685007177	Integrase core domain; Region: rve; cl01316
710685007178	mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965
710685007179	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
710685007180	active site
710685007181	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
710685007182	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
710685007183	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
710685007184	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685007186	S-adenosylmethionine binding site [chemical binding]; other site
710685007187	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
710685007188	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
710685007189	phosphate binding site [ion binding]; other site
710685007190	mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962
710685007191	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
710685007192	FeS/SAM binding site; other site
710685007193	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
710685007194	mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967
710685007195	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007196	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
710685007197	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685007198	active site
710685007199	phosphorylation site [posttranslational modification]
710685007200	intermolecular recognition site; other site
710685007201	dimerization interface [polypeptide binding]; other site
710685007202	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685007203	DNA binding residues [nucleotide binding]
710685007204	dimerization interface [polypeptide binding]; other site
710685007205	Histidine kinase; Region: HisKA_3; pfam07730
710685007206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685007207	ATP binding site [chemical binding]; other site
710685007208	Mg2+ binding site [ion binding]; other site
710685007209	G-X-G motif; other site
710685007210	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
710685007211	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
710685007212	active site
710685007213	NAD binding site [chemical binding]; other site
710685007214	metal binding site [ion binding]; metal-binding site
710685007215	Transposase; Region: DEDD_Tnp_IS110; pfam01548
710685007216	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
710685007217	acetyl-CoA synthetase; Provisional; Region: PRK00174
710685007218	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
710685007219	AMP-binding enzyme; Region: AMP-binding; cl15778
710685007220	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685007221	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
710685007222	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
710685007223	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007224	active site
710685007225	DNA binding site [nucleotide binding]
710685007226	Int/Topo IB signature motif; other site
710685007227	Transposase, Mutator family; Region: Transposase_mut; pfam00872
710685007228	MULE transposase domain; Region: MULE; pfam10551
710685007229	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
710685007230	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685007231	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
710685007232	Transposase, Mutator family; Region: Transposase_mut; pfam00872
710685007233	MULE transposase domain; Region: MULE; pfam10551
710685007234	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
710685007235	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
710685007236	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007237	active site
710685007238	DNA binding site [nucleotide binding]
710685007239	Int/Topo IB signature motif; other site
710685007240	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007241	active site
710685007242	DNA binding site [nucleotide binding]
710685007243	Int/Topo IB signature motif; other site
710685007244	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
710685007245	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007246	active site
710685007247	DNA binding site [nucleotide binding]
710685007248	Int/Topo IB signature motif; other site
710685007249	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685007250	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007251	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
710685007252	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685007253	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007254	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
710685007255	active site
710685007256	DNA binding site [nucleotide binding]
710685007257	Int/Topo IB signature motif; other site
710685007258	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685007259	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
710685007260	RNA binding surface [nucleotide binding]; other site
710685007261	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
710685007262	Cupin superfamily (DUF985); Region: Cupin_5; cl01418
710685007263	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
710685007264	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
710685007265	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
710685007266	putative dimer interface [polypeptide binding]; other site
710685007267	Helix-turn-helix domains; Region: HTH; cl00088
710685007268	Helix-turn-helix domains; Region: HTH; cl00088
710685007269	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
710685007270	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
710685007271	acetyl-CoA acetyltransferase; Provisional; Region: PRK06289
710685007272	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685007273	active site
710685007274	ANTAR domain; Region: ANTAR; cl04297
710685007275	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685007276	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
710685007277	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
710685007278	putative acyl-acceptor binding pocket; other site
710685007279	Cupin domain; Region: Cupin_2; cl09118
710685007280	Cupin domain; Region: Cupin_2; cl09118
710685007281	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685007282	phosphopeptide binding site; other site
710685007283	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685007284	phosphopeptide binding site; other site
710685007285	ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213
710685007286	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
710685007287	Walker A/P-loop; other site
710685007288	ATP binding site [chemical binding]; other site
710685007289	Q-loop/lid; other site
710685007290	ABC transporter signature motif; other site
710685007291	Walker B; other site
710685007292	D-loop; other site
710685007293	H-loop/switch region; other site
710685007294	ABC-2 type transporter; Region: ABC2_membrane; cl11417
710685007295	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685007296	Ligand Binding Site [chemical binding]; other site
710685007297	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
710685007298	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
710685007299	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
710685007300	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007301	active site
710685007302	DNA binding site [nucleotide binding]
710685007303	Int/Topo IB signature motif; other site
710685007304	integrase; Provisional; Region: int; PHA02601
710685007305	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
710685007306	Int/Topo IB signature motif; other site
710685007307	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
710685007308	classical (c) SDRs; Region: SDR_c; cd05233
710685007309	NAD(P) binding site [chemical binding]; other site
710685007310	active site
710685007311	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
710685007312	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
710685007313	alpha subunit interface [polypeptide binding]; other site
710685007314	active site
710685007315	substrate binding site [chemical binding]; other site
710685007316	Fe binding site [ion binding]; other site
710685007317	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
710685007318	oligomerization interface [polypeptide binding]; other site
710685007319	active site
710685007320	metal binding site [ion binding]; metal-binding site
710685007321	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685007322	Transcriptional regulators [Transcription]; Region: FadR; COG2186
710685007323	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685007324	DNA-binding site [nucleotide binding]; DNA binding site
710685007325	FCD domain; Region: FCD; cl11656
710685007326	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
710685007327	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
710685007328	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685007329	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
710685007330	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
710685007331	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007332	NAD(P) binding site [chemical binding]; other site
710685007333	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
710685007334	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685007335	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685007336	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
710685007337	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685007338	NAD(P) binding site [chemical binding]; other site
710685007339	catalytic residues [active]
710685007340	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
710685007341	Transcriptional regulator [Transcription]; Region: IclR; COG1414
710685007342	Helix-turn-helix domains; Region: HTH; cl00088
710685007343	Bacterial transcriptional regulator; Region: IclR; pfam01614
710685007344	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
710685007345	iron-sulfur cluster [ion binding]; other site
710685007346	[2Fe-2S] cluster binding site [ion binding]; other site
710685007347	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
710685007348	beta subunit interface [polypeptide binding]; other site
710685007349	alpha subunit interface [polypeptide binding]; other site
710685007350	active site
710685007351	substrate binding site [chemical binding]; other site
710685007352	Fe binding site [ion binding]; other site
710685007353	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
710685007354	inter-subunit interface; other site
710685007355	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
710685007356	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007357	NAD(P) binding site [chemical binding]; other site
710685007358	active site
710685007359	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
710685007360	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
710685007361	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685007362	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
710685007363	Cupin domain; Region: Cupin_2; cl09118
710685007364	Cupin domain; Region: Cupin_2; cl09118
710685007365	Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952
710685007366	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
710685007367	putative active site [active]
710685007368	catalytic residue [active]
710685007369	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
710685007370	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
710685007371	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
710685007372	active site
710685007373	Fe binding site [ion binding]; other site
710685007374	SCP-2 sterol transfer family; Region: SCP2; cl01225
710685007375	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
710685007376	catalytic residue [active]
710685007377	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
710685007378	inter-subunit interface; other site
710685007379	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
710685007380	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007381	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
710685007382	2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626
710685007383	4Fe-4S binding domain; Region: Fer4; cl02805
710685007384	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685007385	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
710685007386	NAD(P) binding site [chemical binding]; other site
710685007387	catalytic residues [active]
710685007388	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
710685007389	inter-subunit interface; other site
710685007390	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
710685007391	Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535
710685007392	alpha subunit interaction site [polypeptide binding]; other site
710685007393	beta subunit interaction site [polypeptide binding]; other site
710685007394	iron-sulfur cluster [ion binding]; other site
710685007395	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
710685007396	beta subunit interface [polypeptide binding]; other site
710685007397	alpha subunit interface [polypeptide binding]; other site
710685007398	active site
710685007399	substrate binding site [chemical binding]; other site
710685007400	Fe binding site [ion binding]; other site
710685007401	short chain dehydrogenase; Provisional; Region: PRK06138
710685007402	classical (c) SDRs; Region: SDR_c; cd05233
710685007403	NAD(P) binding site [chemical binding]; other site
710685007404	active site
710685007405	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
710685007406	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
710685007407	putative NAD(P) binding site [chemical binding]; other site
710685007408	catalytic Zn binding site [ion binding]; other site
710685007409	VPS10 domain; Region: VPS10; smart00602
710685007410	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
710685007411	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685007412	[2Fe-2S] cluster binding site [ion binding]; other site
710685007413	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685007414	hydrophobic ligand binding site; other site
710685007415	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685007416	SCP-2 sterol transfer family; Region: SCP2; cl01225
710685007417	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
710685007418	active site
710685007419	Permease; Region: Permease; cl00510
710685007420	Permease; Region: Permease; cl00510
710685007421	mce related protein; Region: MCE; pfam02470
710685007422	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685007423	mce related protein; Region: MCE; pfam02470
710685007424	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685007425	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007426	mce related protein; Region: MCE; pfam02470
710685007427	mce related protein; Region: MCE; pfam02470
710685007428	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007429	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007430	mce related protein; Region: MCE; pfam02470
710685007431	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685007432	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007433	mce related protein; Region: MCE; pfam02470
710685007434	Epoxide hydrolase N terminus; Region: EHN; pfam06441
710685007435	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685007436	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685007437	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
710685007438	NAD(P) binding site [chemical binding]; other site
710685007439	catalytic residues [active]
710685007440	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685007441	Major Facilitator Superfamily; Region: MFS_1; pfam07690
710685007442	putative substrate translocation pore; other site
710685007443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685007444	Helix-turn-helix domains; Region: HTH; cl00088
710685007445	Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535
710685007446	alpha subunit interaction site [polypeptide binding]; other site
710685007447	beta subunit interaction site [polypeptide binding]; other site
710685007448	iron-sulfur cluster [ion binding]; other site
710685007449	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
710685007450	beta subunit interface [polypeptide binding]; other site
710685007451	alpha subunit interface [polypeptide binding]; other site
710685007452	active site
710685007453	substrate binding site [chemical binding]; other site
710685007454	Fe binding site [ion binding]; other site
710685007455	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
710685007456	inter-subunit interface; other site
710685007457	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
710685007458	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
710685007459	putative NAD(P) binding site [chemical binding]; other site
710685007460	catalytic Zn binding site [ion binding]; other site
710685007461	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685007462	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685007463	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685007464	active site
710685007465	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685007466	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685007467	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685007468	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
710685007469	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
710685007470	iron-sulfur cluster [ion binding]; other site
710685007471	[2Fe-2S] cluster binding site [ion binding]; other site
710685007472	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
710685007473	beta subunit interface [polypeptide binding]; other site
710685007474	alpha subunit interface [polypeptide binding]; other site
710685007475	active site
710685007476	substrate binding site [chemical binding]; other site
710685007477	Fe binding site [ion binding]; other site
710685007478	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
710685007479	inter-subunit interface; other site
710685007480	Cupin domain; Region: Cupin_2; cl09118
710685007481	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
710685007482	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
710685007483	Helix-turn-helix domains; Region: HTH; cl00088
710685007484	Helix-turn-helix domains; Region: HTH; cl00088
710685007485	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685007486	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685007487	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
710685007488	iron-sulfur cluster [ion binding]; other site
710685007489	[2Fe-2S] cluster binding site [ion binding]; other site
710685007490	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
710685007491	beta subunit interface [polypeptide binding]; other site
710685007492	alpha subunit interface [polypeptide binding]; other site
710685007493	active site
710685007494	substrate binding site [chemical binding]; other site
710685007495	Fe binding site [ion binding]; other site
710685007496	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
710685007497	inter-subunit interface; other site
710685007498	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007499	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
710685007500	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
710685007501	active site
710685007502	metal binding site [ion binding]; metal-binding site
710685007503	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
710685007504	intersubunit interface [polypeptide binding]; other site
710685007505	active site
710685007506	Zn2+ binding site [ion binding]; other site
710685007507	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
710685007508	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007509	NAD(P) binding site [chemical binding]; other site
710685007510	active site
710685007511	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
710685007512	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
710685007513	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
710685007514	active site
710685007515	Fe binding site [ion binding]; other site
710685007516	Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535
710685007517	alpha subunit interaction site [polypeptide binding]; other site
710685007518	beta subunit interaction site [polypeptide binding]; other site
710685007519	iron-sulfur cluster [ion binding]; other site
710685007520	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
710685007521	beta subunit interface [polypeptide binding]; other site
710685007522	alpha subunit interface [polypeptide binding]; other site
710685007523	active site
710685007524	substrate binding site [chemical binding]; other site
710685007525	Fe binding site [ion binding]; other site
710685007526	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
710685007527	inter-subunit interface; other site
710685007528	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
710685007529	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
710685007530	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
710685007531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007532	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
710685007533	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
710685007534	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
710685007535	active site
710685007536	inhibitor site; inhibition site
710685007537	dimer interface [polypeptide binding]; other site
710685007538	catalytic residue [active]
710685007539	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
710685007540	Cupin domain; Region: Cupin_2; cl09118
710685007541	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
710685007542	Helix-turn-helix domains; Region: HTH; cl00088
710685007543	Helix-turn-helix domains; Region: HTH; cl00088
710685007544	Transcriptional regulator [Transcription]; Region: IclR; COG1414
710685007545	Bacterial transcriptional regulator; Region: IclR; pfam01614
710685007546	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
710685007547	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
710685007548	active site
710685007549	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
710685007550	active site
710685007551	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
710685007552	tetramer interface [polypeptide binding]; other site
710685007553	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
710685007554	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685007555	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685007556	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
710685007557	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
710685007558	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
710685007559	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007560	active site
710685007561	DNA binding site [nucleotide binding]
710685007562	Int/Topo IB signature motif; other site
710685007563	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685007564	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685007565	Protein of unknown function (DUF433); Region: DUF433; cl01030
710685007566	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685007567	hypothetical protein; Provisional; Region: PRK07877
710685007568	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
710685007569	FMN binding site [chemical binding]; other site
710685007570	dimer interface [polypeptide binding]; other site
710685007571	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685007572	Ligand Binding Site [chemical binding]; other site
710685007573	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685007574	Ligand Binding Site [chemical binding]; other site
710685007575	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
710685007576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685007577	active site
710685007578	phosphorylation site [posttranslational modification]
710685007579	intermolecular recognition site; other site
710685007580	dimerization interface [polypeptide binding]; other site
710685007581	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685007582	DNA binding residues [nucleotide binding]
710685007583	dimerization interface [polypeptide binding]; other site
710685007584	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685007585	Ligand Binding Site [chemical binding]; other site
710685007586	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
710685007587	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
710685007588	hypothetical protein; Provisional; Region: PRK07877
710685007589	dimer interface [polypeptide binding]; other site
710685007590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
710685007591	Predicted kinase [General function prediction only]; Region: COG0645
710685007592	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685007593	active site
710685007594	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685007595	Ligand Binding Site [chemical binding]; other site
710685007596	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250
710685007597	30S subunit binding site; other site
710685007598	hypothetical protein; Provisional; Region: PRK07877
710685007599	hypothetical protein; Provisional; Region: PRK07877
710685007600	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685007601	Sulfate transporter family; Region: Sulfate_transp; cl15842
710685007602	high affinity sulphate transporter 1; Region: sulP; TIGR00815
710685007603	Sulfate transporter family; Region: Sulfate_transp; cl15842
710685007604	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
710685007605	GAF domain; Region: GAF_2; pfam13185
710685007606	GAF domain; Region: GAF; cl15785
710685007607	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
710685007608	GAF domain; Region: GAF; cl15785
710685007609	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
710685007610	Histidine kinase; Region: HisKA_3; pfam07730
710685007611	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685007612	ATP binding site [chemical binding]; other site
710685007613	Mg2+ binding site [ion binding]; other site
710685007614	G-X-G motif; other site
710685007615	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
710685007616	Subunit I/III interface [polypeptide binding]; other site
710685007617	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
710685007618	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685007619	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
710685007620	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
710685007621	putative anti-sigmaE protein; Provisional; Region: PRK13920
710685007622	Anti-sigma-K factor rskA; Region: RskA; pfam10099
710685007623	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
710685007624	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685007625	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685007626	DNA binding residues [nucleotide binding]
710685007627	Phospholipid methyltransferase; Region: PEMT; cl00763
710685007628	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
710685007629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685007630	S-adenosylmethionine binding site [chemical binding]; other site
710685007631	Uncharacterized conserved protein [Function unknown]; Region: COG3496
710685007632	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
710685007633	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
710685007634	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007635	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
710685007636	putative active site pocket [active]
710685007637	dimerization interface [polypeptide binding]; other site
710685007638	putative catalytic residue [active]
710685007639	Protein of unknown function (DUF867); Region: DUF867; cl01713
710685007640	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
710685007641	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
710685007642	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685007643	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007644	short chain dehydrogenase; Provisional; Region: PRK07814
710685007645	classical (c) SDRs; Region: SDR_c; cd05233
710685007646	NAD(P) binding site [chemical binding]; other site
710685007647	active site
710685007648	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685007649	S-adenosylmethionine binding site [chemical binding]; other site
710685007650	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685007651	Helix-turn-helix domains; Region: HTH; cl00088
710685007652	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
710685007653	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
710685007654	putative DNA binding site [nucleotide binding]; other site
710685007655	putative homodimer interface [polypeptide binding]; other site
710685007656	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
710685007657	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
710685007658	putative substrate binding site [chemical binding]; other site
710685007659	putative ATP binding site [chemical binding]; other site
710685007660	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
710685007661	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
710685007662	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
710685007663	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
710685007664	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
710685007665	inhibitor binding site; inhibition site
710685007666	catalytic Zn binding site [ion binding]; other site
710685007667	structural Zn binding site [ion binding]; other site
710685007668	NADP binding site [chemical binding]; other site
710685007669	tetramer interface [polypeptide binding]; other site
710685007670	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
710685007671	Helix-turn-helix domains; Region: HTH; cl00088
710685007672	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
710685007673	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
710685007674	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685007675	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685007676	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
710685007677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685007678	dimer interface [polypeptide binding]; other site
710685007679	putative PBP binding loops; other site
710685007680	ABC-ATPase subunit interface; other site
710685007681	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
710685007682	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685007683	dimer interface [polypeptide binding]; other site
710685007684	conserved gate region; other site
710685007685	putative PBP binding loops; other site
710685007686	ABC-ATPase subunit interface; other site
710685007687	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
710685007688	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
710685007689	Walker A/P-loop; other site
710685007690	ATP binding site [chemical binding]; other site
710685007691	Q-loop/lid; other site
710685007692	ABC transporter signature motif; other site
710685007693	Walker B; other site
710685007694	D-loop; other site
710685007695	H-loop/switch region; other site
710685007696	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685007697	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
710685007698	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685007699	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685007700	active site
710685007701	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
710685007702	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
710685007703	nucleotide binding site [chemical binding]; other site
710685007704	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
710685007705	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
710685007706	active site
710685007707	DNA binding site [nucleotide binding]
710685007708	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
710685007709	DNA binding site [nucleotide binding]
710685007710	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685007711	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685007712	active site
710685007713	ATP binding site [chemical binding]; other site
710685007714	substrate binding site [chemical binding]; other site
710685007715	activation loop (A-loop); other site
710685007716	kelch-like protein; Provisional; Region: PHA03098
710685007717	Kelch motif; Region: Kelch_1; cl02701
710685007718	Kelch motif; Region: Kelch_1; cl02701
710685007719	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
710685007720	Kelch motif; Region: Kelch_1; cl02701
710685007721	Kelch motif; Region: Kelch_1; cl02701
710685007722	Kelch motif; Region: Kelch_1; cl02701
710685007723	Kelch motif; Region: Kelch_1; cl02701
710685007724	Kelch motif; Region: Kelch_1; cl02701
710685007725	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685007726	phosphopeptide binding site; other site
710685007727	Helix-turn-helix domains; Region: HTH; cl00088
710685007728	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
710685007729	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
710685007730	Transposase; Region: DEDD_Tnp_IS110; pfam01548
710685007731	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
710685007732	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
710685007733	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685007734	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
710685007735	Major Facilitator Superfamily; Region: MFS_1; pfam07690
710685007736	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
710685007737	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
710685007738	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
710685007739	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
710685007740	Membrane protein of unknown function; Region: DUF360; cl00850
710685007741	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
710685007742	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
710685007743	putative DNA binding site [nucleotide binding]; other site
710685007744	catalytic residue [active]
710685007745	putative H2TH interface [polypeptide binding]; other site
710685007746	putative catalytic residues [active]
710685007747	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
710685007748	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
710685007749	Chorismate mutase type II; Region: CM_2; cl00693
710685007750	short chain dehydrogenase; Provisional; Region: PRK08251
710685007751	classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350
710685007752	putative NAD(P) binding site [chemical binding]; other site
710685007753	active site
710685007754	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
710685007755	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
710685007756	active site
710685007757	dimer interface [polypeptide binding]; other site
710685007758	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
710685007759	dimer interface [polypeptide binding]; other site
710685007760	active site
710685007761	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685007762	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
710685007763	tetramerization interface [polypeptide binding]; other site
710685007764	NAD(P) binding site [chemical binding]; other site
710685007765	catalytic residues [active]
710685007766	OpgC protein; Region: OpgC_C; cl00792
710685007767	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
710685007768	Chorismate mutase type II; Region: CM_2; cl00693
710685007769	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
710685007770	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685007771	Family description; Region: UvrD_C_2; cl15862
710685007772	Peptidase family M23; Region: Peptidase_M23; pfam01551
710685007773	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
710685007774	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685007775	CoA-ligase; Region: Ligase_CoA; cl02894
710685007776	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
710685007777	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007778	CoA-ligase; Region: Ligase_CoA; cl02894
710685007779	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
710685007780	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685007781	active site
710685007782	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
710685007783	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685007784	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
710685007785	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
710685007786	active site
710685007787	dimer interface [polypeptide binding]; other site
710685007788	non-prolyl cis peptide bond; other site
710685007789	insertion regions; other site
710685007790	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
710685007791	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
710685007792	active site
710685007793	substrate binding site [chemical binding]; other site
710685007794	cosubstrate binding site; other site
710685007795	catalytic site [active]
710685007796	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
710685007797	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
710685007798	purine monophosphate binding site [chemical binding]; other site
710685007799	dimer interface [polypeptide binding]; other site
710685007800	putative catalytic residues [active]
710685007801	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
710685007802	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
710685007803	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
710685007804	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
710685007805	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685007806	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
710685007807	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685007808	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
710685007809	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
710685007810	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007811	NADH(P)-binding; Region: NAD_binding_10; pfam13460
710685007812	NAD(P) binding site [chemical binding]; other site
710685007813	active site
710685007814	enoyl-CoA hydratase; Provisional; Region: PRK07827
710685007815	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685007816	substrate binding site [chemical binding]; other site
710685007817	oxyanion hole (OAH) forming residues; other site
710685007818	trimer interface [polypeptide binding]; other site
710685007819	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685007820	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
710685007821	active site
710685007822	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
710685007823	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
710685007824	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685007825	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
710685007826	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
710685007827	carboxyltransferase (CT) interaction site; other site
710685007828	biotinylation site [posttranslational modification]; other site
710685007829	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
710685007830	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685007831	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685007832	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685007833	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685007834	active site
710685007835	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
710685007836	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685007837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685007838	active site
710685007839	phosphorylation site [posttranslational modification]
710685007840	intermolecular recognition site; other site
710685007841	dimerization interface [polypeptide binding]; other site
710685007842	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685007843	DNA binding site [nucleotide binding]
710685007844	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
710685007845	dimerization interface [polypeptide binding]; other site
710685007846	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685007847	dimer interface [polypeptide binding]; other site
710685007848	phosphorylation site [posttranslational modification]
710685007849	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685007850	ATP binding site [chemical binding]; other site
710685007851	Mg2+ binding site [ion binding]; other site
710685007852	G-X-G motif; other site
710685007853	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
710685007854	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
710685007855	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
710685007856	MPT binding site; other site
710685007857	trimer interface [polypeptide binding]; other site
710685007858	MspA; Region: MspA; pfam09203
710685007859	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
710685007860	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
710685007861	SAF domain; Region: SAF; cl00555
710685007862	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
710685007863	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
710685007864	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
710685007865	active site
710685007866	tetramer interface; other site
710685007867	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
710685007868	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
710685007869	dimer interface [polypeptide binding]; other site
710685007870	putative functional site; other site
710685007871	putative MPT binding site; other site
710685007872	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
710685007873	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685007874	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
710685007875	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
710685007876	catalytic triad [active]
710685007877	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
710685007878	Protein of unknown function (DUF742); Region: DUF742; pfam05331
710685007879	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
710685007880	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007881	mce related protein; Region: MCE; pfam02470
710685007882	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007883	mce related protein; Region: MCE; pfam02470
710685007884	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007885	mce related protein; Region: MCE; pfam02470
710685007886	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685007887	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007888	mce related protein; Region: MCE; pfam02470
710685007889	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007890	mce related protein; Region: MCE; pfam02470
710685007891	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685007892	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685007893	mce related protein; Region: MCE; pfam02470
710685007894	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685007895	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685007896	Helix-turn-helix domains; Region: HTH; cl00088
710685007897	enoyl-CoA hydratase; Provisional; Region: PRK07509
710685007898	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685007899	substrate binding site [chemical binding]; other site
710685007900	oxyanion hole (OAH) forming residues; other site
710685007901	trimer interface [polypeptide binding]; other site
710685007902	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
710685007903	Phosphotransferase enzyme family; Region: APH; pfam01636
710685007904	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685007905	lipid-transfer protein; Provisional; Region: PRK08256
710685007906	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685007907	active site
710685007908	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685007909	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685007910	Haemolysin-III related; Region: HlyIII; cl03831
710685007911	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
710685007912	nucleotide binding site [chemical binding]; other site
710685007913	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
710685007914	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685007915	NAD(P) binding site [chemical binding]; other site
710685007916	active site
710685007917	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
710685007918	ligand binding site [chemical binding]; other site
710685007919	flexible hinge region; other site
710685007920	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
710685007921	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685007922	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
710685007923	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
710685007924	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
710685007925	shikimate binding site; other site
710685007926	NAD(P) binding site [chemical binding]; other site
710685007927	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
710685007928	PE-PPE domain; Region: PE-PPE; pfam08237
710685007929	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
710685007930	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
710685007931	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
710685007932	DNA binding residues [nucleotide binding]
710685007933	dimer interface [polypeptide binding]; other site
710685007934	[2Fe-2S] cluster binding site [ion binding]; other site
710685007935	Amidinotransferase; Region: Amidinotransf; cl12043
710685007936	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
710685007937	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
710685007938	Predicted methyltransferases [General function prediction only]; Region: COG0313
710685007939	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
710685007940	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
710685007941	chorismate binding enzyme; Region: Chorismate_bind; cl10555
710685007942	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
710685007943	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685007944	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685007945	DNA binding residues [nucleotide binding]
710685007946	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
710685007947	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685007948	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
710685007949	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685007950	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685007951	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685007952	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
710685007953	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685007954	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
710685007955	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
710685007956	active site
710685007957	HIGH motif; other site
710685007958	KMSKS motif; other site
710685007959	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
710685007960	tRNA binding surface [nucleotide binding]; other site
710685007961	anticodon binding site; other site
710685007962	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
710685007963	active site
710685007964	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
710685007965	Domain of unknown function (DUF348); Region: DUF348; pfam03990
710685007966	Domain of unknown function (DUF348); Region: DUF348; pfam03990
710685007967	Domain of unknown function (DUF348); Region: DUF348; pfam03990
710685007968	G5 domain; Region: G5; pfam07501
710685007969	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
710685007970	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685007971	S-adenosylmethionine binding site [chemical binding]; other site
710685007972	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685007973	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685007974	active site
710685007975	ATP binding site [chemical binding]; other site
710685007976	substrate binding site [chemical binding]; other site
710685007977	activation loop (A-loop); other site
710685007978	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
710685007979	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
710685007980	AMP-binding enzyme; Region: AMP-binding; cl15778
710685007981	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685007982	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
710685007983	Walker A/P-loop; other site
710685007984	ATP binding site [chemical binding]; other site
710685007985	Q-loop/lid; other site
710685007986	ABC transporter signature motif; other site
710685007987	Walker B; other site
710685007988	D-loop; other site
710685007989	H-loop/switch region; other site
710685007990	ABC-2 type transporter; Region: ABC2_membrane; cl11417
710685007991	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
710685007992	putative active site [active]
710685007993	putative substrate binding site [chemical binding]; other site
710685007994	ATP binding site [chemical binding]; other site
710685007995	Phosphotransferase enzyme family; Region: APH; pfam01636
710685007996	Helix-turn-helix domains; Region: HTH; cl00088
710685007997	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
710685007998	4Fe-4S binding domain; Region: Fer4; cl02805
710685007999	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12576
710685008000	Cutinase; Region: Cutinase; pfam01083
710685008001	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
710685008002	putative active site [active]
710685008003	catalytic residue [active]
710685008004	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
710685008005	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
710685008006	5S rRNA interface [nucleotide binding]; other site
710685008007	CTC domain interface [polypeptide binding]; other site
710685008008	L16 interface [polypeptide binding]; other site
710685008009	short chain dehydrogenase; Provisional; Region: PRK06197
710685008010	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
710685008011	putative NAD(P) binding site [chemical binding]; other site
710685008012	active site
710685008013	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
710685008014	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
710685008015	ArsC family; Region: ArsC; pfam03960
710685008016	catalytic residues [active]
710685008017	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
710685008018	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
710685008019	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
710685008020	active site
710685008021	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
710685008022	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
710685008023	Substrate binding site; other site
710685008024	Mg++ binding site; other site
710685008025	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
710685008026	active site
710685008027	substrate binding site [chemical binding]; other site
710685008028	CoA binding site [chemical binding]; other site
710685008029	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685008030	Helix-turn-helix domains; Region: HTH; cl00088
710685008031	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
710685008032	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
710685008033	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
710685008034	ATP binding site [chemical binding]; other site
710685008035	putative Mg++ binding site [ion binding]; other site
710685008036	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685008037	nucleotide binding region [chemical binding]; other site
710685008038	ATP-binding site [chemical binding]; other site
710685008039	TRCF domain; Region: TRCF; cl04088
710685008040	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
710685008041	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
710685008042	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
710685008043	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
710685008044	N-acetyl-D-glucosamine binding site [chemical binding]; other site
710685008045	enolase; Provisional; Region: eno; PRK00077
710685008046	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
710685008047	dimer interface [polypeptide binding]; other site
710685008048	metal binding site [ion binding]; metal-binding site
710685008049	substrate binding pocket [chemical binding]; other site
710685008050	Septum formation initiator; Region: DivIC; cl11433
710685008051	Protein of unknown function (DUF501); Region: DUF501; cl00652
710685008052	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
710685008053	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685008054	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
710685008055	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
710685008056	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
710685008057	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
710685008058	catalytic residue [active]
710685008059	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
710685008060	enoyl-CoA hydratase; Provisional; Region: PRK06494
710685008061	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685008062	substrate binding site [chemical binding]; other site
710685008063	oxyanion hole (OAH) forming residues; other site
710685008064	trimer interface [polypeptide binding]; other site
710685008065	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685008066	[2Fe-2S] cluster binding site [ion binding]; other site
710685008067	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
710685008068	putative alpha subunit interface [polypeptide binding]; other site
710685008069	putative active site [active]
710685008070	putative substrate binding site [chemical binding]; other site
710685008071	Fe binding site [ion binding]; other site
710685008072	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
710685008073	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685008074	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
710685008075	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
710685008076	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
710685008077	PaaX-like protein; Region: PaaX; pfam07848
710685008078	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
710685008079	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
710685008080	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
710685008081	AMP-binding enzyme; Region: AMP-binding; cl15778
710685008082	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685008083	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685008084	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
710685008085	hydrophobic ligand binding site; other site
710685008086	Domain of unknown function (DUF309); Region: DUF309; cl00667
710685008087	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
710685008088	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685008089	active site
710685008090	phosphorylation site [posttranslational modification]
710685008091	intermolecular recognition site; other site
710685008092	dimerization interface [polypeptide binding]; other site
710685008093	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685008094	DNA binding site [nucleotide binding]
710685008095	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
710685008096	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
710685008097	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
710685008098	Ligand Binding Site [chemical binding]; other site
710685008099	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685008100	dimer interface [polypeptide binding]; other site
710685008101	phosphorylation site [posttranslational modification]
710685008102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685008103	ATP binding site [chemical binding]; other site
710685008104	Mg2+ binding site [ion binding]; other site
710685008105	G-X-G motif; other site
710685008106	K+-transporting ATPase, c chain; Region: KdpC; cl00944
710685008107	K+-transporting ATPase, c chain; Region: KdpC; cl00944
710685008108	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
710685008109	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
710685008110	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685008111	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
710685008112	EamA-like transporter family; Region: EamA; cl01037
710685008113	EamA-like transporter family; Region: EamA; cl01037
710685008114	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685008115	active site
710685008116	GAF domain; Region: GAF; cl15785
710685008117	GAF domain; Region: GAF_2; pfam13185
710685008118	ANTAR domain; Region: ANTAR; cl04297
710685008119	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
710685008120	metal binding site [ion binding]; metal-binding site
710685008121	active site
710685008122	I-site; other site
710685008123	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
710685008124	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
710685008125	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
710685008126	DNA binding residues [nucleotide binding]
710685008127	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
710685008128	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
710685008129	conserved cys residue [active]
710685008130	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685008131	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
710685008132	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
710685008133	FMN binding site [chemical binding]; other site
710685008134	dimer interface [polypeptide binding]; other site
710685008135	Cupin domain; Region: Cupin_2; cl09118
710685008136	MASE1; Region: MASE1; pfam05231
710685008137	GAF domain; Region: GAF_2; pfam13185
710685008138	GAF domain; Region: GAF; cl15785
710685008139	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
710685008140	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
710685008141	Helix-turn-helix domains; Region: HTH; cl00088
710685008142	DNA binding residues [nucleotide binding]
710685008143	dimerization interface [polypeptide binding]; other site
710685008144	Cutinase; Region: Cutinase; pfam01083
710685008145	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
710685008146	conserved cys residue [active]
710685008147	Emopamil binding protein; Region: EBP; pfam05241
710685008148	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
710685008149	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
710685008150	molybdopterin cofactor binding site; other site
710685008151	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
710685008152	molybdopterin cofactor binding site; other site
710685008153	tetracycline repressor protein TetR; Provisional; Region: PRK13756
710685008154	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
710685008155	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685008156	metabolite-proton symporter; Region: 2A0106; TIGR00883
710685008157	putative substrate translocation pore; other site
710685008158	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685008159	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
710685008160	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
710685008161	Helix-turn-helix domains; Region: HTH; cl00088
710685008162	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
710685008163	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685008164	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
710685008165	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
710685008166	Cl- selectivity filter; other site
710685008167	Cl- binding residues [ion binding]; other site
710685008168	pore gating glutamate residue; other site
710685008169	dimer interface [polypeptide binding]; other site
710685008170	H+/Cl- coupling transport residue; other site
710685008171	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
710685008172	nucleoside/Zn binding site; other site
710685008173	dimer interface [polypeptide binding]; other site
710685008174	catalytic motif [active]
710685008175	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
710685008176	anti sigma factor interaction site; other site
710685008177	regulatory phosphorylation site [posttranslational modification]; other site
710685008178	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
710685008179	Uncharacterized conserved protein [Function unknown]; Region: COG3391
710685008180	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
710685008181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685008182	active site
710685008183	phosphorylation site [posttranslational modification]
710685008184	intermolecular recognition site; other site
710685008185	dimerization interface [polypeptide binding]; other site
710685008186	Helix-turn-helix domains; Region: HTH; cl00088
710685008187	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
710685008188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685008189	ATP binding site [chemical binding]; other site
710685008190	Mg2+ binding site [ion binding]; other site
710685008191	G-X-G motif; other site
710685008192	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
710685008193	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
710685008194	lipid-transfer protein; Provisional; Region: PRK08256
710685008195	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685008196	active site
710685008197	Protein of unknown function (DUF732); Region: DUF732; pfam05305
710685008198	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685008199	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685008200	active site
710685008201	ATP binding site [chemical binding]; other site
710685008202	substrate binding site [chemical binding]; other site
710685008203	activation loop (A-loop); other site
710685008204	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
710685008205	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685008206	DNA binding site [nucleotide binding]
710685008207	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685008208	phosphopeptide binding site; other site
710685008209	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685008210	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685008211	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
710685008212	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685008213	NAD(P) binding site [chemical binding]; other site
710685008214	active site
710685008215	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
710685008216	6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254
710685008217	putative NAD(P) binding site [chemical binding]; other site
710685008218	catalytic Zn binding site [ion binding]; other site
710685008219	structural Zn binding site [ion binding]; other site
710685008220	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685008221	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
710685008222	nucleophile elbow; other site
710685008223	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
710685008224	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
710685008225	active site
710685008226	nucleophile elbow; other site
710685008227	Cysteine dioxygenase type I; Region: CDO_I; cl15835
710685008228	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
710685008229	active site residue [active]
710685008230	Predicted membrane protein [Function unknown]; Region: COG4425
710685008231	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
710685008232	enoyl-CoA hydratase; Provisional; Region: PRK05862
710685008233	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685008234	substrate binding site [chemical binding]; other site
710685008235	oxyanion hole (OAH) forming residues; other site
710685008236	trimer interface [polypeptide binding]; other site
710685008237	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
710685008238	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685008239	substrate binding site [chemical binding]; other site
710685008240	oxyanion hole (OAH) forming residues; other site
710685008241	trimer interface [polypeptide binding]; other site
710685008242	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
710685008243	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
710685008244	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
710685008245	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
710685008246	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
710685008247	dimer interface [polypeptide binding]; other site
710685008248	active site
710685008249	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
710685008250	active site
710685008251	catalytic triad [active]
710685008252	oxyanion hole [active]
710685008253	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685008254	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685008255	substrate binding pocket [chemical binding]; other site
710685008256	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
710685008257	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
710685008258	dimer interface [polypeptide binding]; other site
710685008259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685008260	catalytic residue [active]
710685008261	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
710685008262	Interferon-induced transmembrane protein; Region: CD225; pfam04505
710685008263	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
710685008264	RDD family; Region: RDD; cl00746
710685008265	RDD family; Region: RDD; cl00746
710685008266	cystathionine gamma-synthase; Provisional; Region: PRK07811
710685008267	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
710685008268	homodimer interface [polypeptide binding]; other site
710685008269	substrate-cofactor binding pocket; other site
710685008270	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685008271	catalytic residue [active]
710685008272	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
710685008273	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
710685008274	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
710685008275	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
710685008276	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
710685008277	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
710685008278	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
710685008279	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
710685008280	catalytic residues [active]
710685008281	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685008282	Haemolysin-III related; Region: HlyIII; cl03831
710685008283	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
710685008284	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
710685008285	catalytic residue [active]
710685008286	putative FPP diphosphate  binding site; other site
710685008287	putative FPP binding hydrophobic cleft; other site
710685008288	dimer interface [polypeptide binding]; other site
710685008289	putative IPP diphosphate binding site; other site
710685008290	pantothenate kinase; Provisional; Region: PRK05439
710685008291	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025
710685008292	ATP-binding site [chemical binding]; other site
710685008293	CoA-binding site [chemical binding]; other site
710685008294	Mg2+-binding site [ion binding]; other site
710685008295	serine hydroxymethyltransferase; Provisional; Region: PRK13580
710685008296	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
710685008297	dimer interface [polypeptide binding]; other site
710685008298	active site
710685008299	glycine-pyridoxal phosphate binding site [chemical binding]; other site
710685008300	folate binding site [chemical binding]; other site
710685008301	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
710685008302	dinuclear metal binding motif [ion binding]; other site
710685008303	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
710685008304	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
710685008305	putative active site [active]
710685008306	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685008307	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685008308	TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903
710685008309	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685008310	DNA binding residues [nucleotide binding]
710685008311	dimerization interface [polypeptide binding]; other site
710685008312	fumarate hydratase; Reviewed; Region: fumC; PRK00485
710685008313	Class II fumarases; Region: Fumarase_classII; cd01362
710685008314	active site
710685008315	tetramer interface [polypeptide binding]; other site
710685008316	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
710685008317	putative active site [active]
710685008318	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
710685008319	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
710685008320	Domain of unknown function DUF20; Region: UPF0118; pfam01594
710685008321	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
710685008322	classical (c) SDRs; Region: SDR_c; cd05233
710685008323	short chain dehydrogenase; Provisional; Region: PRK05650
710685008324	NAD(P) binding site [chemical binding]; other site
710685008325	active site
710685008326	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
710685008327	classical (c) SDRs; Region: SDR_c; cd05233
710685008328	NAD(P) binding site [chemical binding]; other site
710685008329	active site
710685008330	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
710685008331	hydrophobic ligand binding site; other site
710685008332	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
710685008333	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685008334	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
710685008335	Sulfatase; Region: Sulfatase; cl10460
710685008336	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
710685008337	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685008338	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
710685008339	NAD(P) binding site [chemical binding]; other site
710685008340	active site
710685008341	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
710685008342	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
710685008343	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
710685008344	generic binding surface II; other site
710685008345	generic binding surface I; other site
710685008346	LytB protein; Region: LYTB; cl00507
710685008347	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
710685008348	GTP-binding protein YchF; Reviewed; Region: PRK09601
710685008349	YchF GTPase; Region: YchF; cd01900
710685008350	G1 box; other site
710685008351	GTP/Mg2+ binding site [chemical binding]; other site
710685008352	Switch I region; other site
710685008353	G2 box; other site
710685008354	Switch II region; other site
710685008355	G3 box; other site
710685008356	G4 box; other site
710685008357	G5 box; other site
710685008358	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
710685008359	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
710685008360	Helix-turn-helix domains; Region: HTH; cl00088
710685008361	Integrase core domain; Region: rve; cl01316
710685008362	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
710685008363	dimer interface [polypeptide binding]; other site
710685008364	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685008365	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
710685008366	OpgC protein; Region: OpgC_C; cl00792
710685008367	Acyltransferase family; Region: Acyl_transf_3; pfam01757
710685008368	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
710685008369	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
710685008370	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
710685008371	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
710685008372	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
710685008373	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
710685008374	cyclase homology domain; Region: CHD; cd07302
710685008375	nucleotidyl binding site; other site
710685008376	metal binding site [ion binding]; metal-binding site
710685008377	dimer interface [polypeptide binding]; other site
710685008378	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685008379	hypothetical protein; Provisional; Region: PRK06149
710685008380	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685008381	active site
710685008382	ATP binding site [chemical binding]; other site
710685008383	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
710685008384	inhibitor-cofactor binding pocket; inhibition site
710685008385	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685008386	catalytic residue [active]
710685008387	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685008388	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685008389	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685008390	Helix-turn-helix domains; Region: HTH; cl00088
710685008391	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
710685008392	dimer interface [polypeptide binding]; other site
710685008393	Permease; Region: Permease; cl00510
710685008394	Permease; Region: Permease; cl00510
710685008395	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685008396	mce related protein; Region: MCE; pfam02470
710685008397	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685008398	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685008399	mce related protein; Region: MCE; pfam02470
710685008400	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685008401	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685008402	mce related protein; Region: MCE; pfam02470
710685008403	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685008404	mce related protein; Region: MCE; pfam02470
710685008405	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685008406	mce related protein; Region: MCE; pfam02470
710685008407	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685008408	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685008409	mce related protein; Region: MCE; pfam02470
710685008410	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685008411	DoxX; Region: DoxX; cl00976
710685008412	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
710685008413	Transcriptional regulators [Transcription]; Region: FadR; COG2186
710685008414	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685008415	FCD domain; Region: FCD; cl11656
710685008416	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
710685008417	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
710685008418	dimer interface [polypeptide binding]; other site
710685008419	active site
710685008420	enoyl-CoA hydratase; Provisional; Region: PRK08252
710685008421	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685008422	substrate binding site [chemical binding]; other site
710685008423	oxyanion hole (OAH) forming residues; other site
710685008424	trimer interface [polypeptide binding]; other site
710685008425	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685008426	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685008427	active site
710685008428	Fasciclin domain; Region: Fasciclin; cl02663
710685008429	Helix-turn-helix domains; Region: HTH; cl00088
710685008430	oxidoreductase; Provisional; Region: PRK06196
710685008431	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
710685008432	putative NAD(P) binding site [chemical binding]; other site
710685008433	active site
710685008434	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
710685008435	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
710685008436	trimer interface [polypeptide binding]; other site
710685008437	putative metal binding site [ion binding]; other site
710685008438	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
710685008439	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685008440	NAD(P) binding site [chemical binding]; other site
710685008441	active site
710685008442	CAAX protease self-immunity; Region: Abi; cl00558
710685008443	H+ Antiporter protein; Region: 2A0121; TIGR00900
710685008444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685008445	putative substrate translocation pore; other site
710685008446	enoyl-CoA hydratase; Provisional; Region: PRK06688
710685008447	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685008448	substrate binding site [chemical binding]; other site
710685008449	oxyanion hole (OAH) forming residues; other site
710685008450	trimer interface [polypeptide binding]; other site
710685008451	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685008452	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685008453	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
710685008454	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
710685008455	NAD binding site [chemical binding]; other site
710685008456	homodimer interface [polypeptide binding]; other site
710685008457	homotetramer interface [polypeptide binding]; other site
710685008458	active site
710685008459	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
710685008460	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
710685008461	FMN binding site [chemical binding]; other site
710685008462	substrate binding site [chemical binding]; other site
710685008463	putative catalytic residue [active]
710685008464	DoxX; Region: DoxX; cl00976
710685008465	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
710685008466	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685008467	Helix-turn-helix domains; Region: HTH; cl00088
710685008468	WHG domain; Region: WHG; pfam13305
710685008469	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
710685008470	NAD+ binding site [chemical binding]; other site
710685008471	substrate binding site [chemical binding]; other site
710685008472	Zn binding site [ion binding]; other site
710685008473	Predicted transcriptional regulators [Transcription]; Region: COG1725
710685008474	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685008475	DNA-binding site [nucleotide binding]; DNA binding site
710685008476	Leucine carboxyl methyltransferase; Region: LCM; cl01306
710685008477	Protein of unknown function (DUF1697); Region: DUF1697; cl01557
710685008478	Leucine carboxyl methyltransferase; Region: LCM; cl01306
710685008479	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685008480	Sodium:solute symporter family; Region: SSF; cl00456
710685008481	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
710685008482	Protein of unknown function, DUF485; Region: DUF485; cl01231
710685008483	Sodium:solute symporter family; Region: SSF; cl00456
710685008484	Sodium:solute symporter family; Region: SSF; cl00456
710685008485	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
710685008486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685008487	active site
710685008488	phosphorylation site [posttranslational modification]
710685008489	intermolecular recognition site; other site
710685008490	dimerization interface [polypeptide binding]; other site
710685008491	LytTr DNA-binding domain; Region: LytTR; cl04498
710685008492	Histidine kinase; Region: His_kinase; pfam06580
710685008493	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685008494	ATP binding site [chemical binding]; other site
710685008495	Mg2+ binding site [ion binding]; other site
710685008496	G-X-G motif; other site
710685008497	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
710685008498	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
710685008499	catalytic residues [active]
710685008500	catalytic nucleophile [active]
710685008501	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
710685008502	FMN binding site [chemical binding]; other site
710685008503	dimer interface [polypeptide binding]; other site
710685008504	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
710685008505	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
710685008506	aromatic arch; other site
710685008507	DCoH dimer interaction site [polypeptide binding]; other site
710685008508	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
710685008509	DCoH tetramer interaction site [polypeptide binding]; other site
710685008510	substrate binding site [chemical binding]; other site
710685008511	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
710685008512	active site
710685008513	8-oxo-dGMP binding site [chemical binding]; other site
710685008514	nudix motif; other site
710685008515	metal binding site [ion binding]; metal-binding site
710685008516	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685008517	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
710685008518	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
710685008519	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
710685008520	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
710685008521	G1 box; other site
710685008522	putative GEF interaction site [polypeptide binding]; other site
710685008523	GTP/Mg2+ binding site [chemical binding]; other site
710685008524	Switch I region; other site
710685008525	G2 box; other site
710685008526	G3 box; other site
710685008527	Switch II region; other site
710685008528	G4 box; other site
710685008529	G5 box; other site
710685008530	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
710685008531	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
710685008532	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
710685008533	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
710685008534	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
710685008535	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
710685008536	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
710685008537	putative ion selectivity filter; other site
710685008538	putative pore gating glutamate residue; other site
710685008539	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
710685008540	FO synthase; Reviewed; Region: fbiC; PRK09234
710685008541	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
710685008542	FeS/SAM binding site; other site
710685008543	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
710685008544	FeS/SAM binding site; other site
710685008545	YceI-like domain; Region: YceI; cl01001
710685008546	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
710685008547	Ferredoxin [Energy production and conversion]; Region: COG1146
710685008548	4Fe-4S binding domain; Region: Fer4; cl02805
710685008549	succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539
710685008550	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
710685008551	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685008552	homodimer interface [polypeptide binding]; other site
710685008553	catalytic residue [active]
710685008554	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
710685008555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685008556	active site
710685008557	phosphorylation site [posttranslational modification]
710685008558	intermolecular recognition site; other site
710685008559	dimerization interface [polypeptide binding]; other site
710685008560	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685008561	DNA binding residues [nucleotide binding]
710685008562	dimerization interface [polypeptide binding]; other site
710685008563	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
710685008564	Histidine kinase; Region: HisKA_3; pfam07730
710685008565	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685008566	ATP binding site [chemical binding]; other site
710685008567	Mg2+ binding site [ion binding]; other site
710685008568	G-X-G motif; other site
710685008569	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
710685008570	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
710685008571	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
710685008572	substrate binding pocket [chemical binding]; other site
710685008573	chain length determination region; other site
710685008574	substrate-Mg2+ binding site; other site
710685008575	catalytic residues [active]
710685008576	aspartate-rich region 1; other site
710685008577	active site lid residues [active]
710685008578	aspartate-rich region 2; other site
710685008579	phytoene desaturase; Region: crtI_fam; TIGR02734
710685008580	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685008581	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
710685008582	active site lid residues [active]
710685008583	substrate binding pocket [chemical binding]; other site
710685008584	catalytic residues [active]
710685008585	substrate-Mg2+ binding site; other site
710685008586	aspartate-rich region 1; other site
710685008587	aspartate-rich region 2; other site
710685008588	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
710685008589	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685008590	Uncharacterized conserved protein [Function unknown]; Region: COG3349
710685008591	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
710685008592	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
710685008593	iron-sulfur cluster [ion binding]; other site
710685008594	[2Fe-2S] cluster binding site [ion binding]; other site
710685008595	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
710685008596	active site
710685008597	metal binding site [ion binding]; metal-binding site
710685008598	nudix motif; other site
710685008599	Helix-turn-helix domains; Region: HTH; cl00088
710685008600	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
710685008601	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685008602	Glutamate binding site [chemical binding]; other site
710685008603	NAD binding site [chemical binding]; other site
710685008604	catalytic residues [active]
710685008605	Proline dehydrogenase; Region: Pro_dh; cl03282
710685008606	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
710685008607	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
710685008608	dimer interface [polypeptide binding]; other site
710685008609	ADP-ribose binding site [chemical binding]; other site
710685008610	active site
710685008611	nudix motif; other site
710685008612	metal binding site [ion binding]; metal-binding site
710685008613	acyl-CoA synthetase; Validated; Region: PRK07787
710685008614	AMP-binding enzyme; Region: AMP-binding; cl15778
710685008615	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685008616	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
710685008617	active site
710685008618	metal binding site [ion binding]; metal-binding site
710685008619	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
710685008620	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
710685008621	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
710685008622	putative trimer interface [polypeptide binding]; other site
710685008623	putative CoA binding site [chemical binding]; other site
710685008624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
710685008625	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
710685008626	metal binding site [ion binding]; metal-binding site
710685008627	putative dimer interface [polypeptide binding]; other site
710685008628	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
710685008629	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685008630	Walker A/P-loop; other site
710685008631	ATP binding site [chemical binding]; other site
710685008632	Q-loop/lid; other site
710685008633	ABC transporter signature motif; other site
710685008634	Walker B; other site
710685008635	D-loop; other site
710685008636	H-loop/switch region; other site
710685008637	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
710685008638	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
710685008639	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
710685008640	AMP-binding enzyme; Region: AMP-binding; cl15778
710685008641	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
710685008642	dihydropteroate synthase; Region: DHPS; TIGR01496
710685008643	substrate binding pocket [chemical binding]; other site
710685008644	dimer interface [polypeptide binding]; other site
710685008645	inhibitor binding site; inhibition site
710685008646	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
710685008647	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
710685008648	active site
710685008649	DivIVA domain; Region: DivI1A_domain; TIGR03544
710685008650	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
710685008651	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
710685008652	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
710685008653	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
710685008654	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
710685008655	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
710685008656	ligand binding site; other site
710685008657	oligomer interface; other site
710685008658	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
710685008659	sulfate 1 binding site; other site
710685008660	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
710685008661	Winged helix-turn helix; Region: HTH_29; pfam13551
710685008662	Integrase core domain; Region: rve; cl01316
710685008663	Integrase core domain; Region: rve_3; cl15866
710685008664	Transposase; Region: DEDD_Tnp_IS110; pfam01548
710685008665	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
710685008666	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685008667	Phospholipid methyltransferase; Region: PEMT; cl00763
710685008668	ABC-2 type transporter; Region: ABC2_membrane; cl11417
710685008669	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
710685008670	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
710685008671	Walker A/P-loop; other site
710685008672	ATP binding site [chemical binding]; other site
710685008673	Q-loop/lid; other site
710685008674	ABC transporter signature motif; other site
710685008675	Walker B; other site
710685008676	D-loop; other site
710685008677	H-loop/switch region; other site
710685008678	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685008679	Helix-turn-helix domains; Region: HTH; cl00088
710685008680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685008681	S-adenosylmethionine binding site [chemical binding]; other site
710685008682	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
710685008683	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685008684	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685008685	DNA binding residues [nucleotide binding]
710685008686	Lipoprotein amino terminal region; Region: Vitellogenin_N; pfam01347
710685008687	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
710685008688	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
710685008689	protein binding site [polypeptide binding]; other site
710685008690	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
710685008691	antiporter inner membrane protein; Provisional; Region: PRK11670
710685008692	Domain of unknown function DUF59; Region: DUF59; cl00941
710685008693	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
710685008694	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
710685008695	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
710685008696	N-acetyl-D-glucosamine binding site [chemical binding]; other site
710685008697	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
710685008698	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
710685008699	MgtE intracellular N domain; Region: MgtE_N; cl15244
710685008700	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
710685008701	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
710685008702	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
710685008703	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
710685008704	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685008705	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
710685008706	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
710685008707	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685008708	dimer interface [polypeptide binding]; other site
710685008709	conserved gate region; other site
710685008710	putative PBP binding loops; other site
710685008711	ABC-ATPase subunit interface; other site
710685008712	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
710685008713	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685008714	dimer interface [polypeptide binding]; other site
710685008715	conserved gate region; other site
710685008716	putative PBP binding loops; other site
710685008717	ABC-ATPase subunit interface; other site
710685008718	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
710685008719	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
710685008720	Walker A/P-loop; other site
710685008721	ATP binding site [chemical binding]; other site
710685008722	Q-loop/lid; other site
710685008723	ABC transporter signature motif; other site
710685008724	Walker B; other site
710685008725	D-loop; other site
710685008726	H-loop/switch region; other site
710685008727	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
710685008728	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
710685008729	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
710685008730	malate dehydrogenase; Provisional; Region: PRK05442
710685008731	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
710685008732	NAD(P) binding site [chemical binding]; other site
710685008733	dimer interface [polypeptide binding]; other site
710685008734	malate binding site [chemical binding]; other site
710685008735	Malic enzyme, N-terminal domain; Region: malic; pfam00390
710685008736	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685008737	NAD(P) binding pocket [chemical binding]; other site
710685008738	NMT1-like family; Region: NMT1_2; cl15260
710685008739	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
710685008740	short chain dehydrogenase; Provisional; Region: PRK06181
710685008741	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685008742	NAD(P) binding site [chemical binding]; other site
710685008743	active site
710685008744	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
710685008745	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
710685008746	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
710685008747	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
710685008748	TPP-binding site [chemical binding]; other site
710685008749	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
710685008750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685008751	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
710685008752	putative substrate translocation pore; other site
710685008753	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685008754	Major Facilitator Superfamily; Region: MFS_1; pfam07690
710685008755	putative substrate translocation pore; other site
710685008756	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
710685008757	FAD binding domain; Region: FAD_binding_4; pfam01565
710685008758	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
710685008759	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
710685008760	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
710685008761	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685008762	Family description; Region: UvrD_C_2; cl15862
710685008763	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
710685008764	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
710685008765	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
710685008766	ATP binding site [chemical binding]; other site
710685008767	Mg++ binding site [ion binding]; other site
710685008768	motif III; other site
710685008769	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685008770	nucleotide binding region [chemical binding]; other site
710685008771	ATP-binding site [chemical binding]; other site
710685008772	DbpA RNA binding domain; Region: DbpA; pfam03880
710685008773	OpgC protein; Region: OpgC_C; cl00792
710685008774	Acyltransferase family; Region: Acyl_transf_3; pfam01757
710685008775	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685008776	Helix-turn-helix domains; Region: HTH; cl00088
710685008777	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685008778	FAD binding domain; Region: FAD_binding_4; pfam01565
710685008779	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
710685008780	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685008781	DNA binding residues [nucleotide binding]
710685008782	dimerization interface [polypeptide binding]; other site
710685008783	H+ Antiporter protein; Region: 2A0121; TIGR00900
710685008784	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685008785	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
710685008786	Fe-S cluster binding site [ion binding]; other site
710685008787	DNA binding site [nucleotide binding]
710685008788	active site
710685008789	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685008790	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685008791	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
710685008792	HIT family signature motif; other site
710685008793	catalytic residue [active]
710685008794	amidase; Provisional; Region: PRK12470
710685008795	Amidase; Region: Amidase; cl11426
710685008796	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
710685008797	putative active site [active]
710685008798	cyclase homology domain; Region: CHD; cd07302
710685008799	nucleotidyl binding site; other site
710685008800	metal binding site [ion binding]; metal-binding site
710685008801	dimer interface [polypeptide binding]; other site
710685008802	Short C-terminal domain; Region: SHOCT; cl01373
710685008803	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
710685008804	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685008805	NAD(P) binding site [chemical binding]; other site
710685008806	active site
710685008807	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685008808	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685008809	active site
710685008810	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
710685008811	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
710685008812	metal-binding site [ion binding]
710685008813	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
710685008814	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
710685008815	metal-binding site [ion binding]
710685008816	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253
710685008817	putative active site [active]
710685008818	dimerization interface [polypeptide binding]; other site
710685008819	putative tRNAtyr binding site [nucleotide binding]; other site
710685008820	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
710685008821	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
710685008822	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
710685008823	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
710685008824	molybdopterin cofactor binding site; other site
710685008825	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
710685008826	molybdopterin cofactor binding site; other site
710685008827	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
710685008828	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
710685008829	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
710685008830	Walker A/P-loop; other site
710685008831	ATP binding site [chemical binding]; other site
710685008832	Q-loop/lid; other site
710685008833	ABC transporter signature motif; other site
710685008834	Walker B; other site
710685008835	D-loop; other site
710685008836	H-loop/switch region; other site
710685008837	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
710685008838	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
710685008839	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685008840	Walker A/P-loop; other site
710685008841	ATP binding site [chemical binding]; other site
710685008842	Q-loop/lid; other site
710685008843	ABC transporter signature motif; other site
710685008844	Walker B; other site
710685008845	D-loop; other site
710685008846	H-loop/switch region; other site
710685008847	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
710685008848	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
710685008849	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
710685008850	catalytic core [active]
710685008851	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
710685008852	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
710685008853	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
710685008854	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
710685008855	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
710685008856	active site
710685008857	metal binding site [ion binding]; metal-binding site
710685008858	DNA binding site [nucleotide binding]
710685008859	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685008860	AAA domain; Region: AAA_27; pfam13514
710685008861	choline dehydrogenase; Validated; Region: PRK02106
710685008862	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
710685008863	Protein of unknown function (DUF1622); Region: DUF1622; cl01991
710685008864	proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
710685008865	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
710685008866	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
710685008867	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
710685008868	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
710685008869	Walker A/P-loop; other site
710685008870	ATP binding site [chemical binding]; other site
710685008871	Q-loop/lid; other site
710685008872	ABC transporter signature motif; other site
710685008873	Walker B; other site
710685008874	D-loop; other site
710685008875	H-loop/switch region; other site
710685008876	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
710685008877	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
710685008878	Walker A/P-loop; other site
710685008879	ATP binding site [chemical binding]; other site
710685008880	Q-loop/lid; other site
710685008881	ABC transporter signature motif; other site
710685008882	Walker B; other site
710685008883	D-loop; other site
710685008884	H-loop/switch region; other site
710685008885	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
710685008886	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
710685008887	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
710685008888	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685008889	dimer interface [polypeptide binding]; other site
710685008890	conserved gate region; other site
710685008891	putative PBP binding loops; other site
710685008892	ABC-ATPase subunit interface; other site
710685008893	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
710685008894	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685008895	dimer interface [polypeptide binding]; other site
710685008896	conserved gate region; other site
710685008897	putative PBP binding loops; other site
710685008898	ABC-ATPase subunit interface; other site
710685008899	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685008900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685008901	active site
710685008902	phosphorylation site [posttranslational modification]
710685008903	intermolecular recognition site; other site
710685008904	dimerization interface [polypeptide binding]; other site
710685008905	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685008906	DNA binding site [nucleotide binding]
710685008907	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
710685008908	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685008909	dimer interface [polypeptide binding]; other site
710685008910	phosphorylation site [posttranslational modification]
710685008911	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685008912	ATP binding site [chemical binding]; other site
710685008913	Mg2+ binding site [ion binding]; other site
710685008914	G-X-G motif; other site
710685008915	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
710685008916	active site
710685008917	GtrA-like protein; Region: GtrA; cl00971
710685008918	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
710685008919	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
710685008920	active site clefts [active]
710685008921	zinc binding site [ion binding]; other site
710685008922	dimer interface [polypeptide binding]; other site
710685008923	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
710685008924	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
710685008925	Active Sites [active]
710685008926	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
710685008927	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
710685008928	CysD dimerization site [polypeptide binding]; other site
710685008929	G1 box; other site
710685008930	putative GEF interaction site [polypeptide binding]; other site
710685008931	GTP/Mg2+ binding site [chemical binding]; other site
710685008932	Switch I region; other site
710685008933	G2 box; other site
710685008934	G3 box; other site
710685008935	Switch II region; other site
710685008936	G4 box; other site
710685008937	G5 box; other site
710685008938	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
710685008939	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
710685008940	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
710685008941	ligand-binding site [chemical binding]; other site
710685008942	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
710685008943	active site
710685008944	Rrf2 family protein; Region: rrf2_super; TIGR00738
710685008945	Helix-turn-helix domains; Region: HTH; cl00088
710685008946	Helix-turn-helix domains; Region: HTH; cl00088
710685008947	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
710685008948	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685008949	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
710685008950	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
710685008951	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
710685008952	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685008953	metal binding site [ion binding]; metal-binding site
710685008954	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
710685008955	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685008956	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
710685008957	Nitronate monooxygenase; Region: NMO; pfam03060
710685008958	FMN binding site [chemical binding]; other site
710685008959	substrate binding site [chemical binding]; other site
710685008960	putative catalytic residue [active]
710685008961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685008962	probable polyamine oxidase; Region: PLN02268
710685008963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685008964	Leucine carboxyl methyltransferase; Region: LCM; cl01306
710685008965	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
710685008966	putative dimer interface [polypeptide binding]; other site
710685008967	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685008968	ligand binding site [chemical binding]; other site
710685008969	Zn binding site [ion binding]; other site
710685008970	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
710685008971	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685008972	short chain dehydrogenase; Provisional; Region: PRK06197
710685008973	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685008974	NAD(P) binding site [chemical binding]; other site
710685008975	active site
710685008976	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685008977	Helix-turn-helix domains; Region: HTH; cl00088
710685008978	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
710685008979	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685008980	Protein of unknown function (DUF732); Region: DUF732; pfam05305
710685008981	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
710685008982	MarC family integral membrane protein; Region: MarC; cl00919
710685008983	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
710685008984	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
710685008985	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
710685008986	NAD(P) binding site [chemical binding]; other site
710685008987	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
710685008988	catalytic triad [active]
710685008989	conserved cis-peptide bond; other site
710685008990	LemA family; Region: LemA; cl00742
710685008991	Peptidase family M48; Region: Peptidase_M48; cl12018
710685008992	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
710685008993	catalytic triad [active]
710685008994	conserved cis-peptide bond; other site
710685008995	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
710685008996	TIR domain; Region: TIR_2; cl15770
710685008997	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
710685008998	nucleotide binding site/active site [active]
710685008999	HIT family signature motif; other site
710685009000	catalytic residue [active]
710685009001	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
710685009002	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
710685009003	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
710685009004	active site
710685009005	HIGH motif; other site
710685009006	KMSK motif region; other site
710685009007	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
710685009008	tRNA binding surface [nucleotide binding]; other site
710685009009	anticodon binding site; other site
710685009010	diaminopimelate decarboxylase; Region: lysA; TIGR01048
710685009011	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
710685009012	active site
710685009013	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
710685009014	substrate binding site [chemical binding]; other site
710685009015	catalytic residues [active]
710685009016	dimer interface [polypeptide binding]; other site
710685009017	homoserine dehydrogenase; Provisional; Region: PRK06349
710685009018	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009019	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
710685009020	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
710685009021	threonine synthase; Reviewed; Region: PRK06721
710685009022	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
710685009023	homodimer interface [polypeptide binding]; other site
710685009024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685009025	catalytic residue [active]
710685009026	homoserine kinase; Provisional; Region: PRK01212
710685009027	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
710685009028	transcription termination factor Rho; Provisional; Region: PRK12608
710685009029	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
710685009030	RNA binding site [nucleotide binding]; other site
710685009031	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
710685009032	multimer interface [polypeptide binding]; other site
710685009033	Walker A motif; other site
710685009034	ATP binding site [chemical binding]; other site
710685009035	Walker B motif; other site
710685009036	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685009037	Helix-turn-helix domains; Region: HTH; cl00088
710685009038	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
710685009039	peptide chain release factor 1; Region: prfA; TIGR00019
710685009040	RF-1 domain; Region: RF-1; cl02875
710685009041	RF-1 domain; Region: RF-1; cl02875
710685009042	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
710685009043	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685009044	S-adenosylmethionine binding site [chemical binding]; other site
710685009045	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
710685009046	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
710685009047	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
710685009048	Mg++ binding site [ion binding]; other site
710685009049	putative catalytic motif [active]
710685009050	substrate binding site [chemical binding]; other site
710685009051	ATP synthase A chain; Region: ATP-synt_A; cl00413
710685009052	ATP synthase subunit C; Region: ATP-synt_C; cl00466
710685009053	Plant ATP synthase F0; Region: YMF19; cl07975
710685009054	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
710685009055	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
710685009056	Plant ATP synthase F0; Region: YMF19; cl07975
710685009057	Plant ATP synthase F0; Region: YMF19; cl07975
710685009058	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
710685009059	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
710685009060	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
710685009061	beta subunit interaction interface [polypeptide binding]; other site
710685009062	Walker A motif; other site
710685009063	ATP binding site [chemical binding]; other site
710685009064	Walker B motif; other site
710685009065	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
710685009066	ATP synthase; Region: ATP-synt; cl00365
710685009067	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
710685009068	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
710685009069	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
710685009070	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
710685009071	alpha subunit interaction interface [polypeptide binding]; other site
710685009072	Walker A motif; other site
710685009073	ATP binding site [chemical binding]; other site
710685009074	Walker B motif; other site
710685009075	inhibitor binding site; inhibition site
710685009076	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
710685009077	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
710685009078	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
710685009079	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
710685009080	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
710685009081	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
710685009082	hinge; other site
710685009083	active site
710685009084	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
710685009085	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
710685009086	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
710685009087	DNA binding site [nucleotide binding]
710685009088	active site
710685009089	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
710685009090	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
710685009091	AlkA N-terminal domain; Region: AlkA_N; cl05528
710685009092	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
710685009093	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
710685009094	minor groove reading motif; other site
710685009095	helix-hairpin-helix signature motif; other site
710685009096	substrate binding pocket [chemical binding]; other site
710685009097	active site
710685009098	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
710685009099	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
710685009100	dimerization interface [polypeptide binding]; other site
710685009101	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
710685009102	cyclase homology domain; Region: CHD; cd07302
710685009103	nucleotidyl binding site; other site
710685009104	metal binding site [ion binding]; metal-binding site
710685009105	dimer interface [polypeptide binding]; other site
710685009106	Protein of unknown function DUF91; Region: DUF91; cl00709
710685009107	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
710685009108	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685009109	dimer interface [polypeptide binding]; other site
710685009110	substrate binding site [chemical binding]; other site
710685009111	metal binding site [ion binding]; metal-binding site
710685009112	putative acyltransferase; Provisional; Region: PRK05790
710685009113	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
710685009114	dimer interface [polypeptide binding]; other site
710685009115	active site
710685009116	Domain of unknown function (DUF3817); Region: DUF3817; cl14844
710685009117	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
710685009118	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
710685009119	glycogen branching enzyme; Provisional; Region: PRK05402
710685009120	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
710685009121	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
710685009122	active site
710685009123	catalytic site [active]
710685009124	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
710685009125	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
710685009126	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
710685009127	active site
710685009128	homodimer interface [polypeptide binding]; other site
710685009129	catalytic site [active]
710685009130	acceptor binding site [chemical binding]; other site
710685009131	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
710685009132	putative homodimer interface [polypeptide binding]; other site
710685009133	putative active site pocket [active]
710685009134	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
710685009135	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
710685009136	MspA; Region: MspA; pfam09203
710685009137	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
710685009138	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
710685009139	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685009140	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685009141	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
710685009142	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
710685009143	active site
710685009144	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
710685009145	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
710685009146	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
710685009147	putative active site pocket [active]
710685009148	cleavage site
710685009149	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
710685009150	MPN+ (JAMM) motif; other site
710685009151	Zinc-binding site [ion binding]; other site
710685009152	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
710685009153	MoaE interaction surface [polypeptide binding]; other site
710685009154	MoeB interaction surface [polypeptide binding]; other site
710685009155	thiocarboxylated glycine; other site
710685009156	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
710685009157	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
710685009158	dimer interface [polypeptide binding]; other site
710685009159	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685009160	catalytic residue [active]
710685009161	Rhomboid family; Region: Rhomboid; cl11446
710685009162	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
710685009163	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685009164	ribonuclease PH; Reviewed; Region: rph; PRK00173
710685009165	Ribonuclease PH; Region: RNase_PH_bact; cd11362
710685009166	hexamer interface [polypeptide binding]; other site
710685009167	active site
710685009168	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
710685009169	active site
710685009170	dimerization interface [polypeptide binding]; other site
710685009171	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685009172	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
710685009173	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685009174	Helix-turn-helix domains; Region: HTH; cl00088
710685009175	haloalkane dehalogenase; Provisional; Region: PRK00870
710685009176	Domain of unknown function (DUF3817); Region: DUF3817; cl14844
710685009177	Glucitol operon activator protein (GutM); Region: GutM; cl01890
710685009178	Helix-turn-helix domains; Region: HTH; cl00088
710685009179	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
710685009180	Amidase; Region: Amidase; cl11426
710685009181	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685009182	classical (c) SDRs; Region: SDR_c; cd05233
710685009183	NAD(P) binding site [chemical binding]; other site
710685009184	active site
710685009185	Transcriptional regulators [Transcription]; Region: MarR; COG1846
710685009186	Helix-turn-helix domains; Region: HTH; cl00088
710685009187	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
710685009188	putative hydrophobic ligand binding site [chemical binding]; other site
710685009189	protein interface [polypeptide binding]; other site
710685009190	gate; other site
710685009191	Transcription factor WhiB; Region: Whib; pfam02467
710685009192	Helix-turn-helix domains; Region: HTH; cl00088
710685009193	Cupin domain; Region: Cupin_2; cl09118
710685009194	Helix-turn-helix domain; Region: HTH_18; pfam12833
710685009195	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685009196	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685009197	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685009198	metabolite-proton symporter; Region: 2A0106; TIGR00883
710685009199	putative substrate translocation pore; other site
710685009200	Protein of unknown function (DUF1445); Region: DUF1445; cl01790
710685009201	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
710685009202	dimerization interface [polypeptide binding]; other site
710685009203	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
710685009204	cyclase homology domain; Region: CHD; cd07302
710685009205	nucleotidyl binding site; other site
710685009206	metal binding site [ion binding]; metal-binding site
710685009207	dimer interface [polypeptide binding]; other site
710685009208	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
710685009209	AMP-binding enzyme; Region: AMP-binding; cl15778
710685009210	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685009211	short chain dehydrogenase; Provisional; Region: PRK08278
710685009212	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009213	NAD(P) binding site [chemical binding]; other site
710685009214	active site
710685009215	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
710685009216	Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884
710685009217	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
710685009218	B12 binding site [chemical binding]; other site
710685009219	cobalt ligand [ion binding]; other site
710685009220	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
710685009221	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685009222	putative CoA-transferase; Provisional; Region: PRK11430
710685009223	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685009224	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685009225	catalytic loop [active]
710685009226	iron binding site [ion binding]; other site
710685009227	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
710685009228	AMP-binding enzyme; Region: AMP-binding; cl15778
710685009229	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685009230	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685009231	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685009232	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685009233	active site
710685009234	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685009235	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685009236	substrate binding site [chemical binding]; other site
710685009237	oxyanion hole (OAH) forming residues; other site
710685009238	trimer interface [polypeptide binding]; other site
710685009239	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
710685009240	Helix-turn-helix domains; Region: HTH; cl00088
710685009241	Integrase core domain; Region: rve; cl01316
710685009242	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685009243	enoyl-CoA hydratase; Provisional; Region: PRK12478
710685009244	substrate binding site [chemical binding]; other site
710685009245	oxyanion hole (OAH) forming residues; other site
710685009246	trimer interface [polypeptide binding]; other site
710685009247	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009248	NAD(P) binding site [chemical binding]; other site
710685009249	active site
710685009250	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
710685009251	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685009252	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685009253	G1 box; other site
710685009254	GTP/Mg2+ binding site [chemical binding]; other site
710685009255	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685009256	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685009257	Helix-turn-helix domains; Region: HTH; cl00088
710685009258	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
710685009259	Subunit I/III interface [polypeptide binding]; other site
710685009260	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
710685009261	Transcriptional regulator [Transcription]; Region: IclR; COG1414
710685009262	Helix-turn-helix domains; Region: HTH; cl00088
710685009263	Bacterial transcriptional regulator; Region: IclR; pfam01614
710685009264	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685009265	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685009266	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
710685009267	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009268	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009269	Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365
710685009270	putative active site [active]
710685009271	Fe(II) binding site [ion binding]; other site
710685009272	putative dimer interface [polypeptide binding]; other site
710685009273	putative tetramer interface [polypeptide binding]; other site
710685009274	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835
710685009275	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685009276	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
710685009277	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009278	NAD(P) binding site [chemical binding]; other site
710685009279	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
710685009280	active site
710685009281	Putative cyclase; Region: Cyclase; cl00814
710685009282	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
710685009283	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685009284	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685009285	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685009286	classical (c) SDRs; Region: SDR_c; cd05233
710685009287	NAD(P) binding site [chemical binding]; other site
710685009288	active site
710685009289	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685009290	Helix-turn-helix domains; Region: HTH; cl00088
710685009291	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
710685009292	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
710685009293	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685009294	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685009295	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
710685009296	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
710685009297	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
710685009298	active site
710685009299	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
710685009300	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
710685009301	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
710685009302	active site
710685009303	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685009304	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685009305	substrate binding site [chemical binding]; other site
710685009306	oxyanion hole (OAH) forming residues; other site
710685009307	trimer interface [polypeptide binding]; other site
710685009308	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685009309	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685009310	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685009311	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685009312	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
710685009313	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
710685009314	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009315	NAD(P) binding site [chemical binding]; other site
710685009316	active site
710685009317	hypothetical protein; Provisional; Region: PRK06194
710685009318	classical (c) SDRs; Region: SDR_c; cd05233
710685009319	NAD(P) binding site [chemical binding]; other site
710685009320	active site
710685009321	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009322	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009323	active site
710685009324	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
710685009325	putative acyl-acceptor binding pocket; other site
710685009326	acyl-CoA synthetase; Provisional; Region: PRK13382
710685009327	AMP-binding enzyme; Region: AMP-binding; cl15778
710685009328	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685009329	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685009330	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685009331	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
710685009332	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
710685009333	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
710685009334	active site
710685009335	ATP binding site [chemical binding]; other site
710685009336	Helix-turn-helix domains; Region: HTH; cl00088
710685009337	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685009338	classical (c) SDRs; Region: SDR_c; cd05233
710685009339	NAD(P) binding site [chemical binding]; other site
710685009340	active site
710685009341	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685009342	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
710685009343	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
710685009344	active site
710685009345	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
710685009346	catalytic triad [active]
710685009347	dimer interface [polypeptide binding]; other site
710685009348	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685009349	Helix-turn-helix domains; Region: HTH; cl00088
710685009350	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685009351	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685009352	active site
710685009353	enoyl-CoA hydratase; Provisional; Region: PRK08290
710685009354	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685009355	substrate binding site [chemical binding]; other site
710685009356	oxyanion hole (OAH) forming residues; other site
710685009357	trimer interface [polypeptide binding]; other site
710685009358	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
710685009359	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009360	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685009361	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009362	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685009363	NAD(P) binding site [chemical binding]; other site
710685009364	active site
710685009365	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685009366	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685009367	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685009368	active site
710685009369	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685009370	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
710685009371	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685009372	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
710685009373	active site
710685009374	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685009375	[2Fe-2S] cluster binding site [ion binding]; other site
710685009376	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
710685009377	alpha subunit interface [polypeptide binding]; other site
710685009378	active site
710685009379	substrate binding site [chemical binding]; other site
710685009380	Fe binding site [ion binding]; other site
710685009381	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685009382	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685009383	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685009384	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685009385	active site
710685009386	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009387	NAD(P) binding site [chemical binding]; other site
710685009388	active site
710685009389	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685009390	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685009391	enoyl-CoA hydratase; Provisional; Region: PRK06688
710685009392	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685009393	substrate binding site [chemical binding]; other site
710685009394	oxyanion hole (OAH) forming residues; other site
710685009395	trimer interface [polypeptide binding]; other site
710685009396	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
710685009397	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
710685009398	dimer interface [polypeptide binding]; other site
710685009399	active site
710685009400	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685009401	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685009402	active site
710685009403	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685009404	Helix-turn-helix domains; Region: HTH; cl00088
710685009405	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
710685009406	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
710685009407	NAD(P) binding site [chemical binding]; other site
710685009408	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
710685009409	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
710685009410	putative active site [active]
710685009411	putative substrate binding site [chemical binding]; other site
710685009412	ATP binding site [chemical binding]; other site
710685009413	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685009414	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685009415	active site
710685009416	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
710685009417	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009418	NAD(P) binding site [chemical binding]; other site
710685009419	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685009420	Helix-turn-helix domains; Region: HTH; cl00088
710685009421	classical (c) SDRs; Region: SDR_c; cd05233
710685009422	NAD(P) binding site [chemical binding]; other site
710685009423	active site
710685009424	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
710685009425	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685009426	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
710685009427	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009428	NAD(P) binding site [chemical binding]; other site
710685009429	active site
710685009430	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685009431	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685009432	active site
710685009433	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
710685009434	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685009435	metal ion-dependent adhesion site (MIDAS); other site
710685009436	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
710685009437	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685009438	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
710685009439	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685009440	Helix-turn-helix domains; Region: HTH; cl00088
710685009441	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685009442	[2Fe-2S] cluster binding site [ion binding]; other site
710685009443	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
710685009444	alpha subunit interface [polypeptide binding]; other site
710685009445	active site
710685009446	substrate binding site [chemical binding]; other site
710685009447	Fe binding site [ion binding]; other site
710685009448	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
710685009449	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685009450	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
710685009451	active site
710685009452	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
710685009453	Helix-turn-helix domains; Region: HTH; cl00088
710685009454	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685009455	catalytic loop [active]
710685009456	iron binding site [ion binding]; other site
710685009457	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685009458	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009459	NAD(P) binding site [chemical binding]; other site
710685009460	active site
710685009461	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685009462	[2Fe-2S] cluster binding site [ion binding]; other site
710685009463	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
710685009464	alpha subunit interface [polypeptide binding]; other site
710685009465	active site
710685009466	substrate binding site [chemical binding]; other site
710685009467	Fe binding site [ion binding]; other site
710685009468	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
710685009469	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
710685009470	substrate binding pocket [chemical binding]; other site
710685009471	active site
710685009472	iron coordination sites [ion binding]; other site
710685009473	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685009474	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
710685009475	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
710685009476	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
710685009477	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685009478	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685009479	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685009480	Cytochrome P450; Region: p450; pfam00067
710685009481	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
710685009482	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
710685009483	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685009484	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
710685009485	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009486	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009487	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
710685009488	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685009489	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
710685009490	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685009491	lipid-transfer protein; Provisional; Region: PRK07855
710685009492	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685009493	active site
710685009494	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
710685009495	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
710685009496	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
710685009497	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
710685009498	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685009499	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
710685009500	iron-sulfur cluster [ion binding]; other site
710685009501	[2Fe-2S] cluster binding site [ion binding]; other site
710685009502	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685009503	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685009504	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685009505	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685009506	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685009507	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685009508	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685009509	active site
710685009510	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685009511	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685009512	substrate binding site [chemical binding]; other site
710685009513	oxyanion hole (OAH) forming residues; other site
710685009514	trimer interface [polypeptide binding]; other site
710685009515	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685009516	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685009517	active site
710685009518	short chain dehydrogenase; Provisional; Region: PRK08278
710685009519	classical (c) SDRs; Region: SDR_c; cd05233
710685009520	NAD(P) binding site [chemical binding]; other site
710685009521	active site
710685009522	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
710685009523	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
710685009524	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
710685009525	PknH-like extracellular domain; Region: PknH_C; pfam14032
710685009526	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685009527	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
710685009528	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
710685009529	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685009530	classical (c) SDRs; Region: SDR_c; cd05233
710685009531	NAD(P) binding site [chemical binding]; other site
710685009532	active site
710685009533	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009534	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685009535	NAD(P) binding site [chemical binding]; other site
710685009536	active site
710685009537	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685009538	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
710685009539	NAD binding site [chemical binding]; other site
710685009540	catalytic residues [active]
710685009541	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685009542	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685009543	Permease; Region: Permease; cl00510
710685009544	Permease; Region: Permease; cl00510
710685009545	mce related protein; Region: MCE; pfam02470
710685009546	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685009547	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685009548	mce related protein; Region: MCE; pfam02470
710685009549	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
710685009550	mce related protein; Region: MCE; pfam02470
710685009551	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685009552	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685009553	mce related protein; Region: MCE; pfam02470
710685009554	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
710685009555	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685009556	mce related protein; Region: MCE; pfam02470
710685009557	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685009558	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685009559	mce related protein; Region: MCE; pfam02470
710685009560	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
710685009561	nudix motif; other site
710685009562	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685009563	Helix-turn-helix domains; Region: HTH; cl00088
710685009564	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889
710685009565	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
710685009566	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685009567	active site
710685009568	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685009569	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685009570	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685009571	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685009572	Uncharacterized conserved protein [Function unknown]; Region: COG4278
710685009573	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685009574	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
710685009575	dimer interface [polypeptide binding]; other site
710685009576	substrate binding site [chemical binding]; other site
710685009577	metal binding site [ion binding]; metal-binding site
710685009578	enoyl-CoA hydratase; Provisional; Region: PRK06563
710685009579	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685009580	substrate binding site [chemical binding]; other site
710685009581	oxyanion hole (OAH) forming residues; other site
710685009582	trimer interface [polypeptide binding]; other site
710685009583	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
710685009584	AMP-binding enzyme; Region: AMP-binding; cl15778
710685009585	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685009586	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
710685009587	AMP-binding enzyme; Region: AMP-binding; cl15778
710685009588	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685009589	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
710685009590	active site
710685009591	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
710685009592	substrate binding site; other site
710685009593	dimer interface; other site
710685009594	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685009595	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
710685009596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685009597	putative substrate translocation pore; other site
710685009598	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778
710685009599	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
710685009600	DNA binding residues [nucleotide binding]
710685009601	putative dimer interface [polypeptide binding]; other site
710685009602	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685009603	dimer interface [polypeptide binding]; other site
710685009604	conserved gate region; other site
710685009605	putative PBP binding loops; other site
710685009606	ABC-ATPase subunit interface; other site
710685009607	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
710685009608	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
710685009609	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
710685009610	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685009611	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
710685009612	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685009613	Walker A/P-loop; other site
710685009614	ATP binding site [chemical binding]; other site
710685009615	Q-loop/lid; other site
710685009616	ABC transporter signature motif; other site
710685009617	Walker B; other site
710685009618	D-loop; other site
710685009619	H-loop/switch region; other site
710685009620	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
710685009621	active site
710685009622	Acyl transferase domain; Region: Acyl_transf_1; cl08282
710685009623	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
710685009624	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
710685009625	phosphate binding site [ion binding]; other site
710685009626	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
710685009627	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
710685009628	putative active site [active]
710685009629	putative catalytic site [active]
710685009630	Acyl transferase domain; Region: Acyl_transf_1; cl08282
710685009631	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
710685009632	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
710685009633	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
710685009634	putative NAD(P) binding site [chemical binding]; other site
710685009635	active site
710685009636	'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828
710685009637	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
710685009638	active site
710685009639	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
710685009640	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
710685009641	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
710685009642	active site
710685009643	metal binding site [ion binding]; metal-binding site
710685009644	dimer interface [polypeptide binding]; other site
710685009645	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
710685009646	catalytic triad [active]
710685009647	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
710685009648	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
710685009649	GAF domain; Region: GAF; cl15785
710685009650	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
710685009651	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
710685009652	Predicted membrane protein [Function unknown]; Region: COG2860
710685009653	UPF0126 domain; Region: UPF0126; pfam03458
710685009654	UPF0126 domain; Region: UPF0126; pfam03458
710685009655	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
710685009656	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
710685009657	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
710685009658	catalytic site [active]
710685009659	putative active site [active]
710685009660	putative substrate binding site [chemical binding]; other site
710685009661	dimer interface [polypeptide binding]; other site
710685009662	Domain of unknown function DUF87; Region: DUF87; pfam01935
710685009663	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
710685009664	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
710685009665	classical (c) SDRs; Region: SDR_c; cd05233
710685009666	NAD(P) binding site [chemical binding]; other site
710685009667	active site
710685009668	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
710685009669	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
710685009670	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685009671	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685009672	Helix-turn-helix domains; Region: HTH; cl00088
710685009673	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
710685009674	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685009675	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685009676	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
710685009677	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
710685009678	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685009679	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
710685009680	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
710685009681	carboxyltransferase (CT) interaction site; other site
710685009682	biotinylation site [posttranslational modification]; other site
710685009683	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685009684	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685009685	active site
710685009686	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
710685009687	putative active site [active]
710685009688	putative catalytic site [active]
710685009689	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
710685009690	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
710685009691	Helix-turn-helix domains; Region: HTH; cl00088
710685009692	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
710685009693	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
710685009694	tetramer interface [polypeptide binding]; other site
710685009695	TPP-binding site [chemical binding]; other site
710685009696	heterodimer interface [polypeptide binding]; other site
710685009697	phosphorylation loop region [posttranslational modification]
710685009698	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
710685009699	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
710685009700	alpha subunit interface [polypeptide binding]; other site
710685009701	TPP binding site [chemical binding]; other site
710685009702	heterodimer interface [polypeptide binding]; other site
710685009703	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
710685009704	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
710685009705	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
710685009706	E3 interaction surface; other site
710685009707	lipoyl attachment site [posttranslational modification]; other site
710685009708	e3 binding domain; Region: E3_binding; pfam02817
710685009709	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
710685009710	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685009711	enoyl-CoA hydratase; Provisional; Region: PRK07799
710685009712	substrate binding site [chemical binding]; other site
710685009713	oxyanion hole (OAH) forming residues; other site
710685009714	trimer interface [polypeptide binding]; other site
710685009715	PE-PPE domain; Region: PE-PPE; pfam08237
710685009716	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685009717	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685009718	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
710685009719	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685009720	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
710685009721	putative acyl-acceptor binding pocket; other site
710685009722	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
710685009723	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
710685009724	putative acyl-acceptor binding pocket; other site
710685009725	Copper resistance protein D; Region: CopD; cl00563
710685009726	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
710685009727	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
710685009728	dimer interface [polypeptide binding]; other site
710685009729	ssDNA binding site [nucleotide binding]; other site
710685009730	tetramer (dimer of dimers) interface [polypeptide binding]; other site
710685009731	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
710685009732	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685009733	Walker A/P-loop; other site
710685009734	ATP binding site [chemical binding]; other site
710685009735	Q-loop/lid; other site
710685009736	ABC transporter signature motif; other site
710685009737	Walker B; other site
710685009738	D-loop; other site
710685009739	H-loop/switch region; other site
710685009740	ABC transporter; Region: ABC_tran_2; pfam12848
710685009741	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
710685009742	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
710685009743	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
710685009744	active site
710685009745	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
710685009746	Helix-turn-helix domains; Region: HTH; cl00088
710685009747	Integrase core domain; Region: rve; cl01316
710685009748	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
710685009749	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
710685009750	active site
710685009751	catalytic site [active]
710685009752	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
710685009753	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
710685009754	apolar tunnel; other site
710685009755	heme binding site [chemical binding]; other site
710685009756	dimerization interface [polypeptide binding]; other site
710685009757	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685009758	active site
710685009759	Repair protein; Region: Repair_PSII; cl01535
710685009760	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
710685009761	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
710685009762	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
710685009763	Zn binding site [ion binding]; other site
710685009764	Protein of unknown function (DUF732); Region: DUF732; pfam05305
710685009765	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
710685009766	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
710685009767	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
710685009768	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
710685009769	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
710685009770	putative DNA binding site [nucleotide binding]; other site
710685009771	catalytic residue [active]
710685009772	putative H2TH interface [polypeptide binding]; other site
710685009773	putative catalytic residues [active]
710685009774	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
710685009775	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
710685009776	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
710685009777	GAF domain; Region: GAF; cl15785
710685009778	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
710685009779	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
710685009780	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
710685009781	trigger factor; Provisional; Region: tig; PRK01490
710685009782	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
710685009783	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
710685009784	Clp protease; Region: CLP_protease; pfam00574
710685009785	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
710685009786	oligomer interface [polypeptide binding]; other site
710685009787	active site residues [active]
710685009788	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
710685009789	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
710685009790	oligomer interface [polypeptide binding]; other site
710685009791	active site residues [active]
710685009792	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
710685009793	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
710685009794	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685009795	Walker A motif; other site
710685009796	ATP binding site [chemical binding]; other site
710685009797	Walker B motif; other site
710685009798	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
710685009799	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
710685009800	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
710685009801	active site
710685009802	TDP-binding site; other site
710685009803	acceptor substrate-binding pocket; other site
710685009804	homodimer interface [polypeptide binding]; other site
710685009805	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685009806	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
710685009807	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
710685009808	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
710685009809	putative molybdopterin cofactor binding site [chemical binding]; other site
710685009810	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
710685009811	putative molybdopterin cofactor binding site; other site
710685009812	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685009813	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685009814	active site
710685009815	Winged helix-turn helix; Region: HTH_29; pfam13551
710685009816	Integrase core domain; Region: rve; cl01316
710685009817	Integrase core domain; Region: rve_3; cl15866
710685009818	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
710685009819	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
710685009820	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
710685009821	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
710685009822	putative homotetramer interface [polypeptide binding]; other site
710685009823	putative homodimer interface [polypeptide binding]; other site
710685009824	putative allosteric switch controlling residues; other site
710685009825	putative metal binding site [ion binding]; other site
710685009826	putative homodimer-homodimer interface [polypeptide binding]; other site
710685009827	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
710685009828	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
710685009829	active site residue [active]
710685009830	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
710685009831	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
710685009832	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685009833	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
710685009834	active site residue [active]
710685009835	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
710685009836	active site residue [active]
710685009837	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
710685009838	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
710685009839	catalytic residues [active]
710685009840	Domain of unknown function DUF302; Region: DUF302; cl01364
710685009841	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
710685009842	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685009843	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
710685009844	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
710685009845	active site residue [active]
710685009846	hypothetical protein; Provisional; Region: PRK06062
710685009847	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
710685009848	inhibitor-cofactor binding pocket; inhibition site
710685009849	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685009850	catalytic residue [active]
710685009851	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
710685009852	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685009853	tetrameric interface [polypeptide binding]; other site
710685009854	NAD binding site [chemical binding]; other site
710685009855	catalytic residues [active]
710685009856	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
710685009857	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
710685009858	AP (apurinic/apyrimidinic) site pocket; other site
710685009859	Metal-binding active site; metal-binding site
710685009860	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
710685009861	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009862	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
710685009863	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
710685009864	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
710685009865	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
710685009866	dimer interface [polypeptide binding]; other site
710685009867	PYR/PP interface [polypeptide binding]; other site
710685009868	TPP binding site [chemical binding]; other site
710685009869	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
710685009870	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
710685009871	TPP-binding site; other site
710685009872	KduI/IolB family; Region: KduI; cl01508
710685009873	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
710685009874	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
710685009875	substrate binding site [chemical binding]; other site
710685009876	ATP binding site [chemical binding]; other site
710685009877	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
710685009878	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685009879	DNA-binding site [nucleotide binding]; DNA binding site
710685009880	UTRA domain; Region: UTRA; cl01230
710685009881	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
710685009882	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
710685009883	DNA interaction; other site
710685009884	Metal-binding active site; metal-binding site
710685009885	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
710685009886	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
710685009887	putative ligand binding site [chemical binding]; other site
710685009888	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
710685009889	TM-ABC transporter signature motif; other site
710685009890	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
710685009891	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
710685009892	Walker A/P-loop; other site
710685009893	ATP binding site [chemical binding]; other site
710685009894	Q-loop/lid; other site
710685009895	ABC transporter signature motif; other site
710685009896	Walker B; other site
710685009897	D-loop; other site
710685009898	H-loop/switch region; other site
710685009899	AMP-binding domain protein; Validated; Region: PRK08315
710685009900	AMP-binding enzyme; Region: AMP-binding; cl15778
710685009901	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685009902	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685009903	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685009904	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
710685009905	active site
710685009906	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
710685009907	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
710685009908	FAD binding site [chemical binding]; other site
710685009909	substrate binding site [chemical binding]; other site
710685009910	catalytic base [active]
710685009911	enoyl-CoA hydratase; Provisional; Region: PRK08290
710685009912	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685009913	substrate binding site [chemical binding]; other site
710685009914	oxyanion hole (OAH) forming residues; other site
710685009915	trimer interface [polypeptide binding]; other site
710685009916	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685009917	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
710685009918	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
710685009919	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685009920	catalytic loop [active]
710685009921	iron binding site [ion binding]; other site
710685009922	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
710685009923	FAD binding pocket [chemical binding]; other site
710685009924	FAD binding motif [chemical binding]; other site
710685009925	phosphate binding motif [ion binding]; other site
710685009926	beta-alpha-beta structure motif; other site
710685009927	NAD binding pocket [chemical binding]; other site
710685009928	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
710685009929	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685009930	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685009931	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
710685009932	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
710685009933	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
710685009934	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
710685009935	dimerization interface [polypeptide binding]; other site
710685009936	active site
710685009937	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
710685009938	classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944
710685009939	homodimer interface [polypeptide binding]; other site
710685009940	putative NAD(P) binding site [chemical binding]; other site
710685009941	active site
710685009942	Helix-turn-helix domains; Region: HTH; cl00088
710685009943	Protein of unknown function (DUF3457); Region: DUF3457; cl08122
710685009944	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685009945	Helix-turn-helix domains; Region: HTH; cl00088
710685009946	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685009947	Permease; Region: Permease; cl00510
710685009948	Permease; Region: Permease; cl00510
710685009949	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685009950	mce related protein; Region: MCE; pfam02470
710685009951	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685009952	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685009953	mce related protein; Region: MCE; pfam02470
710685009954	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685009955	mce related protein; Region: MCE; pfam02470
710685009956	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685009957	mce related protein; Region: MCE; pfam02470
710685009958	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685009959	mce related protein; Region: MCE; pfam02470
710685009960	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
710685009961	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
710685009962	mce related protein; Region: MCE; pfam02470
710685009963	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
710685009964	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
710685009965	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685009966	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685009967	GAF domain; Region: GAF; cl15785
710685009968	GAF domain; Region: GAF_2; pfam13185
710685009969	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685009970	DNA binding residues [nucleotide binding]
710685009971	dimerization interface [polypeptide binding]; other site
710685009972	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
710685009973	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009974	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
710685009975	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
710685009976	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685009977	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
710685009978	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
710685009979	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
710685009980	DNA binding site [nucleotide binding]
710685009981	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
710685009982	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
710685009983	putative ligand binding site [chemical binding]; other site
710685009984	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
710685009985	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
710685009986	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
710685009987	dimer interface [polypeptide binding]; other site
710685009988	PYR/PP interface [polypeptide binding]; other site
710685009989	TPP binding site [chemical binding]; other site
710685009990	substrate binding site [chemical binding]; other site
710685009991	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
710685009992	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
710685009993	TPP-binding site [chemical binding]; other site
710685009994	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
710685009995	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
710685009996	GTP binding site; other site
710685009997	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
710685009998	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
710685009999	hypothetical protein; Provisional; Region: PRK06847
710685010000	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685010001	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685010002	CoenzymeA binding site [chemical binding]; other site
710685010003	subunit interaction site [polypeptide binding]; other site
710685010004	PHB binding site; other site
710685010005	Helix-turn-helix domains; Region: HTH; cl00088
710685010006	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
710685010007	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685010008	Uncharacterized conserved protein [Function unknown]; Region: COG3268
710685010009	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
710685010010	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
710685010011	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
710685010012	active site
710685010013	HIGH motif; other site
710685010014	nucleotide binding site [chemical binding]; other site
710685010015	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
710685010016	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
710685010017	active site
710685010018	KMSKS motif; other site
710685010019	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
710685010020	tRNA binding surface [nucleotide binding]; other site
710685010021	anticodon binding site; other site
710685010022	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
710685010023	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
710685010024	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
710685010025	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
710685010026	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
710685010027	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
710685010028	active site
710685010029	multimer interface [polypeptide binding]; other site
710685010030	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
710685010031	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
710685010032	homodimer interface [polypeptide binding]; other site
710685010033	oligonucleotide binding site [chemical binding]; other site
710685010034	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
710685010035	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
710685010036	GTPase CgtA; Reviewed; Region: obgE; PRK12296
710685010037	GTP1/OBG; Region: GTP1_OBG; pfam01018
710685010038	Obg GTPase; Region: Obg; cd01898
710685010039	G1 box; other site
710685010040	GTP/Mg2+ binding site [chemical binding]; other site
710685010041	Switch I region; other site
710685010042	G2 box; other site
710685010043	G3 box; other site
710685010044	Switch II region; other site
710685010045	G4 box; other site
710685010046	G5 box; other site
710685010047	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
710685010048	gamma-glutamyl kinase; Provisional; Region: PRK05429
710685010049	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
710685010050	nucleotide binding site [chemical binding]; other site
710685010051	homotetrameric interface [polypeptide binding]; other site
710685010052	putative phosphate binding site [ion binding]; other site
710685010053	putative allosteric binding site; other site
710685010054	PUA domain; Region: PUA; cl00607
710685010055	NAD-dependent deacetylase; Provisional; Region: PRK00481
710685010056	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
710685010057	Isochorismatase family; Region: Isochorismatase; pfam00857
710685010058	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
710685010059	catalytic triad [active]
710685010060	conserved cis-peptide bond; other site
710685010061	NAD synthetase; Reviewed; Region: nadE; PRK02628
710685010062	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
710685010063	multimer interface [polypeptide binding]; other site
710685010064	active site
710685010065	catalytic triad [active]
710685010066	protein interface 1 [polypeptide binding]; other site
710685010067	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
710685010068	homodimer interface [polypeptide binding]; other site
710685010069	NAD binding pocket [chemical binding]; other site
710685010070	ATP binding pocket [chemical binding]; other site
710685010071	Mg binding site [ion binding]; other site
710685010072	active-site loop [active]
710685010073	Phospholipid methyltransferase; Region: PEMT; cl00763
710685010074	Cation efflux family; Region: Cation_efflux; cl00316
710685010075	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
710685010076	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685010077	putative DNA binding site [nucleotide binding]; other site
710685010078	dimerization interface [polypeptide binding]; other site
710685010079	putative Zn2+ binding site [ion binding]; other site
710685010080	Winged helix-turn helix; Region: HTH_29; pfam13551
710685010081	Helix-turn-helix domains; Region: HTH; cl00088
710685010082	Helix-turn-helix domains; Region: HTH; cl00088
710685010083	putative transposase OrfB; Reviewed; Region: PHA02517
710685010084	Integrase core domain; Region: rve; cl01316
710685010085	Integrase core domain; Region: rve_3; cl15866
710685010086	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685010087	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685010088	substrate binding site [chemical binding]; other site
710685010089	oxyanion hole (OAH) forming residues; other site
710685010090	trimer interface [polypeptide binding]; other site
710685010091	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
710685010092	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
710685010093	substrate binding site [chemical binding]; other site
710685010094	dimer interface [polypeptide binding]; other site
710685010095	ATP binding site [chemical binding]; other site
710685010096	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
710685010097	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
710685010098	putative catalytic cysteine [active]
710685010099	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
710685010100	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685010101	Walker A motif; other site
710685010102	ATP binding site [chemical binding]; other site
710685010103	Walker B motif; other site
710685010104	arginine finger; other site
710685010105	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
710685010106	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685010107	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
710685010108	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
710685010109	active site
710685010110	(T/H)XGH motif; other site
710685010111	Oligomerisation domain; Region: Oligomerisation; cl00519
710685010112	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
710685010113	catalytic core [active]
710685010114	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
710685010115	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
710685010116	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685010117	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685010118	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685010119	classical (c) SDRs; Region: SDR_c; cd05233
710685010120	NAD(P) binding site [chemical binding]; other site
710685010121	active site
710685010122	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685010123	CoenzymeA binding site [chemical binding]; other site
710685010124	subunit interaction site [polypeptide binding]; other site
710685010125	PHB binding site; other site
710685010126	Helix-turn-helix domains; Region: HTH; cl00088
710685010127	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845
710685010128	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
710685010129	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
710685010130	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685010131	hydrophobic ligand binding site; other site
710685010132	Helix-turn-helix domains; Region: HTH; cl00088
710685010133	HTH-like domain; Region: HTH_21; pfam13276
710685010134	Integrase core domain; Region: rve; cl01316
710685010135	Integrase core domain; Region: rve_3; cl15866
710685010136	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685010137	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685010138	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
710685010139	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
710685010140	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685010141	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685010142	classical (c) SDRs; Region: SDR_c; cd05233
710685010143	NAD(P) binding site [chemical binding]; other site
710685010144	active site
710685010145	acyl-CoA synthetase; Validated; Region: PRK08316
710685010146	AMP-binding enzyme; Region: AMP-binding; cl15778
710685010147	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685010148	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685010149	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685010150	active site
710685010151	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685010152	human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338
710685010153	NAD(P) binding site [chemical binding]; other site
710685010154	homodimer interface [polypeptide binding]; other site
710685010155	active site
710685010156	Stress responsive A/B Barrel Domain; Region: Dabb; cl15807
710685010157	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685010158	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685010159	Transcriptional regulator [Transcription]; Region: IclR; COG1414
710685010160	Helix-turn-helix domains; Region: HTH; cl00088
710685010161	Bacterial transcriptional regulator; Region: IclR; pfam01614
710685010162	hypothetical protein; Validated; Region: PRK07121
710685010163	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
710685010164	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
710685010165	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
710685010166	active site
710685010167	Fe binding site [ion binding]; other site
710685010168	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685010169	active site
710685010170	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685010171	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685010172	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685010173	classical (c) SDRs; Region: SDR_c; cd05233
710685010174	NAD(P) binding site [chemical binding]; other site
710685010175	active site
710685010176	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685010177	classical (c) SDRs; Region: SDR_c; cd05233
710685010178	NAD(P) binding site [chemical binding]; other site
710685010179	active site
710685010180	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
710685010181	comEA protein; Region: comE; TIGR01259
710685010182	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
710685010183	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
710685010184	Competence protein; Region: Competence; cl00471
710685010185	hypothetical protein; Reviewed; Region: PRK07914
710685010186	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
710685010187	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
710685010188	Uncharacterized conserved protein [Function unknown]; Region: COG2308
710685010189	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
710685010190	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
710685010191	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
710685010192	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
710685010193	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685010194	Putative esterase; Region: Esterase; pfam00756
710685010195	Cutinase; Region: Cutinase; pfam01083
710685010196	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685010197	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
710685010198	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
710685010199	active site
710685010200	catalytic tetrad [active]
710685010201	FOG: CBS domain [General function prediction only]; Region: COG0517
710685010202	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
710685010203	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685010204	PemK-like protein; Region: PemK; cl00995
710685010205	GTP-binding protein LepA; Provisional; Region: PRK05433
710685010206	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
710685010207	G1 box; other site
710685010208	putative GEF interaction site [polypeptide binding]; other site
710685010209	GTP/Mg2+ binding site [chemical binding]; other site
710685010210	Switch I region; other site
710685010211	G2 box; other site
710685010212	G3 box; other site
710685010213	Switch II region; other site
710685010214	G4 box; other site
710685010215	G5 box; other site
710685010216	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
710685010217	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
710685010218	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
710685010219	PknH-like extracellular domain; Region: PknH_C; pfam14032
710685010220	PknH-like extracellular domain; Region: PknH_C; pfam14032
710685010221	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685010222	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
710685010223	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
710685010224	active site residue [active]
710685010225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
710685010226	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685010227	ANTAR domain; Region: ANTAR; cl04297
710685010228	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
710685010229	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733
710685010230	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
710685010231	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685010232	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685010233	active site
710685010234	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
710685010235	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
710685010236	hypothetical protein; Provisional; Region: PRK06185
710685010237	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685010238	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685010239	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
710685010240	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
710685010241	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685010242	dimer interface [polypeptide binding]; other site
710685010243	conserved gate region; other site
710685010244	putative PBP binding loops; other site
710685010245	ABC-ATPase subunit interface; other site
710685010246	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685010247	dimer interface [polypeptide binding]; other site
710685010248	conserved gate region; other site
710685010249	putative PBP binding loops; other site
710685010250	ABC-ATPase subunit interface; other site
710685010251	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296
710685010252	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
710685010253	Walker A/P-loop; other site
710685010254	ATP binding site [chemical binding]; other site
710685010255	Q-loop/lid; other site
710685010256	ABC transporter signature motif; other site
710685010257	Walker B; other site
710685010258	D-loop; other site
710685010259	H-loop/switch region; other site
710685010260	TOBE-like domain; Region: TOBE_3; pfam12857
710685010261	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
710685010262	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685010263	active site
710685010264	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685010265	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
710685010266	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
710685010267	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
710685010268	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
710685010269	Amino acid permease; Region: AA_permease; pfam00324
710685010270	Spore germination protein; Region: Spore_permease; cl15802
710685010271	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
710685010272	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685010273	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
710685010274	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
710685010275	Walker A/P-loop; other site
710685010276	ATP binding site [chemical binding]; other site
710685010277	Q-loop/lid; other site
710685010278	ABC transporter signature motif; other site
710685010279	Walker B; other site
710685010280	D-loop; other site
710685010281	H-loop/switch region; other site
710685010282	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
710685010283	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
710685010284	substrate binding pocket [chemical binding]; other site
710685010285	membrane-bound complex binding site; other site
710685010286	hinge residues; other site
710685010287	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
710685010288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
710685010289	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
710685010290	active site residue [active]
710685010291	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685010292	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685010293	active site
710685010294	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
710685010295	active site
710685010296	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
710685010297	non-prolyl cis peptide bond; other site
710685010298	Sodium:solute symporter family; Region: SSF; cl00456
710685010299	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
710685010300	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685010301	Protein of unknown function (DUF1684); Region: DUF1684; cl01327
710685010302	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
710685010303	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
710685010304	putative active site [active]
710685010305	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
710685010306	putative active site [active]
710685010307	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
710685010308	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
710685010309	Active Sites [active]
710685010310	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
710685010311	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
710685010312	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
710685010313	coproporphyrinogen III oxidase; Validated; Region: PRK05628
710685010314	HemN C-terminal domain; Region: HemN_C; pfam06969
710685010315	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
710685010316	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685010317	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685010318	DNA binding residues [nucleotide binding]
710685010319	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
710685010320	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
710685010321	active site
710685010322	Acyl transferase domain; Region: Acyl_transf_1; cl08282
710685010323	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
710685010324	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
710685010325	putative NADP binding site [chemical binding]; other site
710685010326	active site
710685010327	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685010328	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
710685010329	AMP-binding enzyme; Region: AMP-binding; cl15778
710685010330	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685010331	Condensation domain; Region: Condensation; pfam00668
710685010332	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
710685010333	Nonribosomal peptide synthase; Region: NRPS; pfam08415
710685010334	AMP-binding enzyme; Region: AMP-binding; cl15778
710685010335	L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443
710685010336	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685010337	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685010338	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
710685010339	peptide synthase; Provisional; Region: PRK12467
710685010340	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685010341	AMP-binding enzyme; Region: AMP-binding; cl15778
710685010342	AMP-binding enzyme; Region: AMP-binding; cl15778
710685010343	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685010344	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685010345	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685010346	peptide synthase; Provisional; Region: PRK12316
710685010347	AMP-binding enzyme; Region: AMP-binding; cl15778
710685010348	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685010349	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
710685010350	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
710685010351	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
710685010352	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685010353	Walker A/P-loop; other site
710685010354	ATP binding site [chemical binding]; other site
710685010355	Q-loop/lid; other site
710685010356	ABC transporter signature motif; other site
710685010357	Walker B; other site
710685010358	D-loop; other site
710685010359	H-loop/switch region; other site
710685010360	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
710685010361	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
710685010362	FAD binding pocket [chemical binding]; other site
710685010363	FAD binding motif [chemical binding]; other site
710685010364	phosphate binding motif [ion binding]; other site
710685010365	NAD binding pocket [chemical binding]; other site
710685010366	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
710685010367	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
710685010368	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
710685010369	Walker A/P-loop; other site
710685010370	ATP binding site [chemical binding]; other site
710685010371	Q-loop/lid; other site
710685010372	ABC transporter signature motif; other site
710685010373	Walker B; other site
710685010374	D-loop; other site
710685010375	H-loop/switch region; other site
710685010376	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270
710685010377	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
710685010378	Helix-turn-helix domains; Region: HTH; cl00088
710685010379	HrcA protein C terminal domain; Region: HrcA; pfam01628
710685010380	chaperone protein DnaJ; Provisional; Region: PRK14278
710685010381	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
710685010382	HSP70 interaction site [polypeptide binding]; other site
710685010383	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
710685010384	Zn binding sites [ion binding]; other site
710685010385	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
710685010386	dimer interface [polypeptide binding]; other site
710685010387	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
710685010388	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
710685010389	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
710685010390	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
710685010391	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
710685010392	active site
710685010393	Acyl transferase domain; Region: Acyl_transf_1; cl08282
710685010394	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
710685010395	NADP binding site [chemical binding]; other site
710685010396	active site
710685010397	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685010398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685010399	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
710685010400	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
710685010401	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685010402	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
710685010403	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
710685010404	Domain of unknown function DUF21; Region: DUF21; pfam01595
710685010405	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
710685010406	Transporter associated domain; Region: CorC_HlyC; cl08393
710685010407	GTPase Era; Reviewed; Region: era; PRK00089
710685010408	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
710685010409	G1 box; other site
710685010410	GTP/Mg2+ binding site [chemical binding]; other site
710685010411	Switch I region; other site
710685010412	G2 box; other site
710685010413	Switch II region; other site
710685010414	G3 box; other site
710685010415	G4 box; other site
710685010416	G5 box; other site
710685010417	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
710685010418	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
710685010419	amidase; Provisional; Region: PRK06061
710685010420	Amidase; Region: Amidase; cl11426
710685010421	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
710685010422	Recombination protein O N terminal; Region: RecO_N; cl15812
710685010423	Recombination protein O C terminal; Region: RecO_C; pfam02565
710685010424	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
710685010425	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
710685010426	catalytic residue [active]
710685010427	putative FPP diphosphate  binding site; other site
710685010428	putative FPP binding hydrophobic cleft; other site
710685010429	dimer interface [polypeptide binding]; other site
710685010430	putative IPP diphosphate binding site; other site
710685010431	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
710685010432	metal binding site 2 [ion binding]; metal-binding site
710685010433	putative DNA binding helix; other site
710685010434	metal binding site 1 [ion binding]; metal-binding site
710685010435	dimer interface [polypeptide binding]; other site
710685010436	structural Zn2+ binding site [ion binding]; other site
710685010437	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685010438	dimerization interface [polypeptide binding]; other site
710685010439	putative DNA binding site [nucleotide binding]; other site
710685010440	putative Zn2+ binding site [ion binding]; other site
710685010441	glycyl-tRNA synthetase; Provisional; Region: PRK04173
710685010442	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
710685010443	motif 1; other site
710685010444	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774
710685010445	active site
710685010446	motif 2; other site
710685010447	motif 3; other site
710685010448	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
710685010449	anticodon binding site; other site
710685010450	Repair protein; Region: Repair_PSII; cl01535
710685010451	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
710685010452	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
710685010453	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
710685010454	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
710685010455	DNA primase; Validated; Region: dnaG; PRK05667
710685010456	CHC2 zinc finger; Region: zf-CHC2; cl15369
710685010457	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
710685010458	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
710685010459	active site
710685010460	metal binding site [ion binding]; metal-binding site
710685010461	interdomain interaction site; other site
710685010462	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
710685010463	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
710685010464	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685010465	active site
710685010466	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
710685010467	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
710685010468	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685010469	putative substrate translocation pore; other site
710685010470	Major Facilitator Superfamily; Region: MFS_1; pfam07690
710685010471	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
710685010472	Helix-turn-helix domains; Region: HTH; cl00088
710685010473	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
710685010474	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
710685010475	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
710685010476	Walker A/P-loop; other site
710685010477	ATP binding site [chemical binding]; other site
710685010478	Q-loop/lid; other site
710685010479	ABC transporter signature motif; other site
710685010480	Walker B; other site
710685010481	D-loop; other site
710685010482	H-loop/switch region; other site
710685010483	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
710685010484	Walker A/P-loop; other site
710685010485	ATP binding site [chemical binding]; other site
710685010486	Q-loop/lid; other site
710685010487	ABC transporter signature motif; other site
710685010488	Walker B; other site
710685010489	D-loop; other site
710685010490	H-loop/switch region; other site
710685010491	Cobalt transport protein; Region: CbiQ; cl00463
710685010492	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
710685010493	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
710685010494	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
710685010495	Uncharacterized conserved protein [Function unknown]; Region: COG2128
710685010496	MspA; Region: MspA; pfam09203
710685010497	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685010498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685010499	active site
710685010500	phosphorylation site [posttranslational modification]
710685010501	intermolecular recognition site; other site
710685010502	dimerization interface [polypeptide binding]; other site
710685010503	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685010504	DNA binding site [nucleotide binding]
710685010505	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
710685010506	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685010507	dimer interface [polypeptide binding]; other site
710685010508	phosphorylation site [posttranslational modification]
710685010509	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685010510	ATP binding site [chemical binding]; other site
710685010511	Mg2+ binding site [ion binding]; other site
710685010512	G-X-G motif; other site
710685010513	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
710685010514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685010515	active site
710685010516	phosphorylation site [posttranslational modification]
710685010517	intermolecular recognition site; other site
710685010518	dimerization interface [polypeptide binding]; other site
710685010519	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685010520	DNA binding site [nucleotide binding]
710685010521	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
710685010522	active site
710685010523	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
710685010524	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
710685010525	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
710685010526	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
710685010527	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
710685010528	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
710685010529	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
710685010530	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
710685010531	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
710685010532	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685010533	Helix-turn-helix domains; Region: HTH; cl00088
710685010534	Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143
710685010535	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
710685010536	active site
710685010537	HIGH motif; other site
710685010538	nucleotide binding site [chemical binding]; other site
710685010539	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
710685010540	active site
710685010541	KMSKS motif; other site
710685010542	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685010543	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685010544	cyclase homology domain; Region: CHD; cd07302
710685010545	nucleotidyl binding site; other site
710685010546	metal binding site [ion binding]; metal-binding site
710685010547	dimer interface [polypeptide binding]; other site
710685010548	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
710685010549	N-acetyl-D-glucosamine binding site [chemical binding]; other site
710685010550	catalytic residue [active]
710685010551	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685010552	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685010553	active site
710685010554	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685010555	classical (c) SDRs; Region: SDR_c; cd05233
710685010556	NAD(P) binding site [chemical binding]; other site
710685010557	active site
710685010558	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
710685010559	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
710685010560	Walker A/P-loop; other site
710685010561	ATP binding site [chemical binding]; other site
710685010562	Q-loop/lid; other site
710685010563	ABC transporter signature motif; other site
710685010564	Walker B; other site
710685010565	D-loop; other site
710685010566	H-loop/switch region; other site
710685010567	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
710685010568	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
710685010569	Walker A/P-loop; other site
710685010570	ATP binding site [chemical binding]; other site
710685010571	Q-loop/lid; other site
710685010572	ABC transporter signature motif; other site
710685010573	Walker B; other site
710685010574	D-loop; other site
710685010575	H-loop/switch region; other site
710685010576	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
710685010577	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
710685010578	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685010579	dimer interface [polypeptide binding]; other site
710685010580	conserved gate region; other site
710685010581	putative PBP binding loops; other site
710685010582	ABC-ATPase subunit interface; other site
710685010583	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
710685010584	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685010585	dimer interface [polypeptide binding]; other site
710685010586	conserved gate region; other site
710685010587	putative PBP binding loops; other site
710685010588	ABC-ATPase subunit interface; other site
710685010589	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516
710685010590	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
710685010591	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
710685010592	classical (c) SDRs; Region: SDR_c; cd05233
710685010593	NAD(P) binding site [chemical binding]; other site
710685010594	active site
710685010595	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685010596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685010597	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
710685010598	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685010599	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685010600	active site
710685010601	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
710685010602	DJ-1 family protein; Region: not_thiJ; TIGR01383
710685010603	conserved cys residue [active]
710685010604	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
710685010605	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
710685010606	conserved cys residue [active]
710685010607	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685010608	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685010609	SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109
710685010610	short chain dehydrogenase; Provisional; Region: PRK06197
710685010611	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
710685010612	putative NAD(P) binding site [chemical binding]; other site
710685010613	active site
710685010614	Helix-turn-helix domains; Region: HTH; cl00088
710685010615	Short C-terminal domain; Region: SHOCT; cl01373
710685010616	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685010617	mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
710685010618	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
710685010619	NAD binding site [chemical binding]; other site
710685010620	catalytic Zn binding site [ion binding]; other site
710685010621	substrate binding site [chemical binding]; other site
710685010622	structural Zn binding site [ion binding]; other site
710685010623	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685010624	DNA binding residues [nucleotide binding]
710685010625	dimerization interface [polypeptide binding]; other site
710685010626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685010627	S-adenosylmethionine binding site [chemical binding]; other site
710685010628	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
710685010629	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
710685010630	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685010631	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
710685010632	Protein of unknown function (DUF732); Region: DUF732; pfam05305
710685010633	diacylglycerol kinase; Reviewed; Region: PRK11914
710685010634	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
710685010635	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
710685010636	FAD binding domain; Region: FAD_binding_4; pfam01565
710685010637	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685010638	Helix-turn-helix domains; Region: HTH; cl00088
710685010639	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
710685010640	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
710685010641	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685010642	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685010643	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
710685010644	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
710685010645	dimer interface [polypeptide binding]; other site
710685010646	active site
710685010647	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
710685010648	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
710685010649	dimer interface [polypeptide binding]; other site
710685010650	active site
710685010651	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685010652	Acyl transferase domain; Region: Acyl_transf_1; cl08282
710685010653	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
710685010654	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
710685010655	Helix-turn-helix domains; Region: HTH; cl00088
710685010656	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
710685010657	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
710685010658	dimer interface [polypeptide binding]; other site
710685010659	TPP-binding site [chemical binding]; other site
710685010660	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
710685010661	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
710685010662	dimer interface [polypeptide binding]; other site
710685010663	catalytic triad [active]
710685010664	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
710685010665	FMN binding site [chemical binding]; other site
710685010666	dimer interface [polypeptide binding]; other site
710685010667	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685010668	Protein of unknown function (DUF2855); Region: DUF2855; pfam11017
710685010669	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685010670	Ligand Binding Site [chemical binding]; other site
710685010671	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685010672	Ligand Binding Site [chemical binding]; other site
710685010673	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
710685010674	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685010675	active site
710685010676	metal binding site [ion binding]; metal-binding site
710685010677	CobD/Cbib protein; Region: CobD_Cbib; cl00561
710685010678	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
710685010679	Low molecular weight phosphatase family; Region: LMWPc; cd00115
710685010680	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
710685010681	active site
710685010682	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
710685010683	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685010684	motif II; other site
710685010685	hypothetical protein; Provisional; Region: PRK07908
710685010686	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
710685010687	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685010688	homodimer interface [polypeptide binding]; other site
710685010689	catalytic residue [active]
710685010690	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
710685010691	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
710685010692	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
710685010693	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
710685010694	Putative zinc ribbon domain; Region: DUF164; pfam02591
710685010695	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
710685010696	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
710685010697	RNA/DNA hybrid binding site [nucleotide binding]; other site
710685010698	active site
710685010699	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
710685010700	catalytic core [active]
710685010701	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
710685010702	sequence-specific DNA binding site [nucleotide binding]; other site
710685010703	salt bridge; other site
710685010704	Cupin domain; Region: Cupin_2; cl09118
710685010705	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
710685010706	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685010707	S-adenosylmethionine binding site [chemical binding]; other site
710685010708	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
710685010709	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
710685010710	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
710685010711	DNA binding site [nucleotide binding]
710685010712	Phospholipid methyltransferase; Region: PEMT; cl00763
710685010713	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685010714	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
710685010715	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685010716	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
710685010717	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685010718	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685010719	dimerization interface [polypeptide binding]; other site
710685010720	putative DNA binding site [nucleotide binding]; other site
710685010721	putative Zn2+ binding site [ion binding]; other site
710685010722	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
710685010723	Membrane transport protein; Region: Mem_trans; cl09117
710685010724	Low molecular weight phosphatase family; Region: LMWPc; cd00115
710685010725	active site
710685010726	Low molecular weight phosphatase family; Region: LMWPc; cl00105
710685010727	DinB superfamily; Region: DinB_2; pfam12867
710685010728	Transcriptional regulators [Transcription]; Region: GntR; COG1802
710685010729	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685010730	DNA-binding site [nucleotide binding]; DNA binding site
710685010731	FCD domain; Region: FCD; cl11656
710685010732	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
710685010733	putative active site; other site
710685010734	putative metal binding residues [ion binding]; other site
710685010735	signature motif; other site
710685010736	putative triphosphate binding site [ion binding]; other site
710685010737	CHAD domain; Region: CHAD; cl10506
710685010738	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685010739	enoyl-CoA hydratase; Provisional; Region: PRK06688
710685010740	substrate binding site [chemical binding]; other site
710685010741	oxyanion hole (OAH) forming residues; other site
710685010742	trimer interface [polypeptide binding]; other site
710685010743	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
710685010744	oligomerization interface [polypeptide binding]; other site
710685010745	active site
710685010746	metal binding site [ion binding]; metal-binding site
710685010747	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685010748	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685010749	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
710685010750	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685010751	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
710685010752	Coenzyme A binding pocket [chemical binding]; other site
710685010753	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
710685010754	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
710685010755	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
710685010756	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
710685010757	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
710685010758	metal binding triad; other site
710685010759	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
710685010760	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
710685010761	metal binding triad; other site
710685010762	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
710685010763	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685010764	CoenzymeA binding site [chemical binding]; other site
710685010765	subunit interaction site [polypeptide binding]; other site
710685010766	PHB binding site; other site
710685010767	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
710685010768	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685010769	DoxX; Region: DoxX; cl00976
710685010770	glutamine synthetase, type I; Region: GlnA; TIGR00653
710685010771	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
710685010772	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
710685010773	RDD family; Region: RDD; cl00746
710685010774	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
710685010775	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
710685010776	active site
710685010777	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
710685010778	lipoyl synthase; Provisional; Region: PRK05481
710685010779	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
710685010780	FeS/SAM binding site; other site
710685010781	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
710685010782	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
710685010783	TIGR01777 family protein; Region: yfcH
710685010784	putative NAD(P) binding site [chemical binding]; other site
710685010785	putative active site [active]
710685010786	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
710685010787	E3 interaction surface; other site
710685010788	lipoyl attachment site [posttranslational modification]; other site
710685010789	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
710685010790	E3 interaction surface; other site
710685010791	lipoyl attachment site [posttranslational modification]; other site
710685010792	e3 binding domain; Region: E3_binding; pfam02817
710685010793	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
710685010794	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
710685010795	short chain dehydrogenase; Validated; Region: PRK05855
710685010796	classical (c) SDRs; Region: SDR_c; cd05233
710685010797	NAD(P) binding site [chemical binding]; other site
710685010798	active site
710685010799	multifunctional aminopeptidase A; Provisional; Region: PRK00913
710685010800	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
710685010801	interface (dimer of trimers) [polypeptide binding]; other site
710685010802	Substrate-binding/catalytic site; other site
710685010803	Zn-binding sites [ion binding]; other site
710685010804	cyclase homology domain; Region: CHD; cd07302
710685010805	nucleotidyl binding site; other site
710685010806	metal binding site [ion binding]; metal-binding site
710685010807	dimer interface [polypeptide binding]; other site
710685010808	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
710685010809	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
710685010810	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
710685010811	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
710685010812	homodimer interface [polypeptide binding]; other site
710685010813	substrate-cofactor binding pocket; other site
710685010814	catalytic residue [active]
710685010815	Protein of unknown function (DUF732); Region: DUF732; pfam05305
710685010816	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
710685010817	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
710685010818	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
710685010819	putative dimer interface [polypeptide binding]; other site
710685010820	active site pocket [active]
710685010821	putative cataytic base [active]
710685010822	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
710685010823	homotrimer interface [polypeptide binding]; other site
710685010824	Walker A motif; other site
710685010825	GTP binding site [chemical binding]; other site
710685010826	Walker B motif; other site
710685010827	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
710685010828	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
710685010829	Transposase; Region: DEDD_Tnp_IS110; pfam01548
710685010830	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
710685010831	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
710685010832	substrate binding site [chemical binding]; other site
710685010833	ATP binding site [chemical binding]; other site
710685010834	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
710685010835	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
710685010836	active site
710685010837	dimer interface [polypeptide binding]; other site
710685010838	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
710685010839	Ligand Binding Site [chemical binding]; other site
710685010840	Molecular Tunnel; other site
710685010841	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
710685010842	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
710685010843	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
710685010844	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
710685010845	Protein of unknown function (DUF2561); Region: DUF2561; pfam10812
710685010846	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
710685010847	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
710685010848	heme bH binding site [chemical binding]; other site
710685010849	intrachain domain interface; other site
710685010850	heme bL binding site [chemical binding]; other site
710685010851	interchain domain interface [polypeptide binding]; other site
710685010852	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
710685010853	Qo binding site; other site
710685010854	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
710685010855	iron-sulfur cluster [ion binding]; other site
710685010856	[2Fe-2S] cluster binding site [ion binding]; other site
710685010857	Cytochrome c; Region: Cytochrom_C; cl11414
710685010858	Cytochrome c; Region: Cytochrom_C; cl11414
710685010859	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
710685010860	Subunit I/III interface [polypeptide binding]; other site
710685010861	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
710685010862	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
710685010863	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
710685010864	hypothetical protein; Validated; Region: PRK07883
710685010865	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
710685010866	active site
710685010867	catalytic site [active]
710685010868	substrate binding site [chemical binding]; other site
710685010869	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
710685010870	GIY-YIG motif/motif A; other site
710685010871	active site
710685010872	catalytic site [active]
710685010873	putative DNA binding site [nucleotide binding]; other site
710685010874	metal binding site [ion binding]; metal-binding site
710685010875	NlpC/P60 family; Region: NLPC_P60; cl11438
710685010876	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
710685010877	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
710685010878	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
710685010879	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
710685010880	AMP-binding enzyme; Region: AMP-binding; cl15778
710685010881	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685010882	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
710685010883	putative hydrophobic ligand binding site [chemical binding]; other site
710685010884	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
710685010885	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
710685010886	P loop; other site
710685010887	Nucleotide binding site [chemical binding]; other site
710685010888	DTAP/Switch II; other site
710685010889	Switch I; other site
710685010890	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
710685010891	putative acyl-acceptor binding pocket; other site
710685010892	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
710685010893	Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230
710685010894	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685010895	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685010896	active site
710685010897	ATP binding site [chemical binding]; other site
710685010898	substrate binding site [chemical binding]; other site
710685010899	activation loop (A-loop); other site
710685010900	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
710685010901	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
710685010902	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
710685010903	substrate binding pocket [chemical binding]; other site
710685010904	chain length determination region; other site
710685010905	substrate-Mg2+ binding site; other site
710685010906	catalytic residues [active]
710685010907	aspartate-rich region 1; other site
710685010908	active site lid residues [active]
710685010909	aspartate-rich region 2; other site
710685010910	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
710685010911	cell division protein MraZ; Reviewed; Region: PRK00326
710685010912	MraZ protein; Region: MraZ; pfam02381
710685010913	MraZ protein; Region: MraZ; pfam02381
710685010914	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685010915	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
710685010916	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
710685010917	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
710685010918	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685010919	Probable transposase; Region: OrfB_IS605; pfam01385
710685010920	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
710685010921	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
710685010922	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
710685010923	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
710685010924	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
710685010925	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
710685010926	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
710685010927	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
710685010928	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
710685010929	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
710685010930	Mg++ binding site [ion binding]; other site
710685010931	putative catalytic motif [active]
710685010932	putative substrate binding site [chemical binding]; other site
710685010933	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685010934	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
710685010935	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
710685010936	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
710685010937	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
710685010938	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
710685010939	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
710685010940	active site
710685010941	homodimer interface [polypeptide binding]; other site
710685010942	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
710685010943	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
710685010944	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
710685010945	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
710685010946	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
710685010947	Cell division protein FtsQ; Region: FtsQ; pfam03799
710685010948	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
710685010949	nucleotide binding site [chemical binding]; other site
710685010950	SulA interaction site; other site
710685010951	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
710685010952	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
710685010953	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
710685010954	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
710685010955	catalytic residue [active]
710685010956	Protein of unknown function (DUF552); Region: DUF552; cl00775
710685010957	YGGT family; Region: YGGT; cl00508
710685010958	DivIVA domain; Region: DivI1A_domain; TIGR03544
710685010959	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
710685010960	Plant ATP synthase F0; Region: YMF19; cl07975
710685010961	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
710685010962	active site
710685010963	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
710685010964	putative hydrophobic ligand binding site [chemical binding]; other site
710685010965	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685010966	TIGR01777 family protein; Region: yfcH
710685010967	NAD(P) binding site [chemical binding]; other site
710685010968	active site
710685010969	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
710685010970	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
710685010971	catalytic triad [active]
710685010972	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685010973	Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104
710685010974	putative active site [active]
710685010975	catalytic site [active]
710685010976	Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105
710685010977	putative active site [active]
710685010978	catalytic site [active]
710685010979	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685010980	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
710685010981	Winged helix-turn helix; Region: HTH_29; pfam13551
710685010982	Integrase core domain; Region: rve; cl01316
710685010983	Integrase core domain; Region: rve_3; cl15866
710685010984	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685010985	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685010986	active site
710685010987	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685010988	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685010989	classical (c) SDRs; Region: SDR_c; cd05233
710685010990	NAD(P) binding site [chemical binding]; other site
710685010991	active site
710685010992	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685010993	Helix-turn-helix domains; Region: HTH; cl00088
710685010994	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
710685010995	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
710685010996	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
710685010997	active site
710685010998	dimer interface [polypeptide binding]; other site
710685010999	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
710685011000	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
710685011001	active site
710685011002	FMN binding site [chemical binding]; other site
710685011003	substrate binding site [chemical binding]; other site
710685011004	3Fe-4S cluster binding site [ion binding]; other site
710685011005	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
710685011006	domain interface; other site
710685011007	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
710685011008	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011009	pyruvate kinase; Provisional; Region: PRK06247
710685011010	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
710685011011	domain interfaces; other site
710685011012	active site
710685011013	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
710685011014	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
710685011015	active site
710685011016	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
710685011017	catalytic triad [active]
710685011018	dimer interface [polypeptide binding]; other site
710685011019	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
710685011020	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685011021	Walker A/P-loop; other site
710685011022	ATP binding site [chemical binding]; other site
710685011023	Q-loop/lid; other site
710685011024	ABC transporter signature motif; other site
710685011025	Walker B; other site
710685011026	D-loop; other site
710685011027	H-loop/switch region; other site
710685011028	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
710685011029	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
710685011030	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685011031	Walker A/P-loop; other site
710685011032	ATP binding site [chemical binding]; other site
710685011033	Q-loop/lid; other site
710685011034	ABC transporter signature motif; other site
710685011035	Walker B; other site
710685011036	D-loop; other site
710685011037	H-loop/switch region; other site
710685011038	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
710685011039	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
710685011040	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
710685011041	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
710685011042	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
710685011043	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
710685011044	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
710685011045	substrate binding pocket [chemical binding]; other site
710685011046	membrane-bound complex binding site; other site
710685011047	hinge residues; other site
710685011048	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
710685011049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685011050	dimer interface [polypeptide binding]; other site
710685011051	conserved gate region; other site
710685011052	putative PBP binding loops; other site
710685011053	ABC-ATPase subunit interface; other site
710685011054	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
710685011055	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
710685011056	Walker A/P-loop; other site
710685011057	ATP binding site [chemical binding]; other site
710685011058	Q-loop/lid; other site
710685011059	ABC transporter signature motif; other site
710685011060	Walker B; other site
710685011061	D-loop; other site
710685011062	H-loop/switch region; other site
710685011063	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
710685011064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
710685011065	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
710685011066	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685011067	active site
710685011068	phosphorylation site [posttranslational modification]
710685011069	intermolecular recognition site; other site
710685011070	dimerization interface [polypeptide binding]; other site
710685011071	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
710685011072	DNA binding residues [nucleotide binding]
710685011073	dimerization interface [polypeptide binding]; other site
710685011074	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
710685011075	Ferritin-like domain; Region: Ferritin; pfam00210
710685011076	dimerization interface [polypeptide binding]; other site
710685011077	DPS ferroxidase diiron center [ion binding]; other site
710685011078	ion pore; other site
710685011079	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
710685011080	cyclase homology domain; Region: CHD; cd07302
710685011081	nucleotidyl binding site; other site
710685011082	metal binding site [ion binding]; metal-binding site
710685011083	dimer interface [polypeptide binding]; other site
710685011084	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
710685011085	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685011086	active site
710685011087	phosphorylation site [posttranslational modification]
710685011088	intermolecular recognition site; other site
710685011089	dimerization interface [polypeptide binding]; other site
710685011090	ANTAR domain; Region: ANTAR; cl04297
710685011091	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
710685011092	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
710685011093	dimerization interface [polypeptide binding]; other site
710685011094	ligand binding site [chemical binding]; other site
710685011095	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
710685011096	TM-ABC transporter signature motif; other site
710685011097	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
710685011098	TM-ABC transporter signature motif; other site
710685011099	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
710685011100	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
710685011101	Walker A/P-loop; other site
710685011102	ATP binding site [chemical binding]; other site
710685011103	Q-loop/lid; other site
710685011104	ABC transporter signature motif; other site
710685011105	Walker B; other site
710685011106	D-loop; other site
710685011107	H-loop/switch region; other site
710685011108	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
710685011109	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
710685011110	Walker A/P-loop; other site
710685011111	ATP binding site [chemical binding]; other site
710685011112	Q-loop/lid; other site
710685011113	ABC transporter signature motif; other site
710685011114	Walker B; other site
710685011115	D-loop; other site
710685011116	H-loop/switch region; other site
710685011117	lipid-transfer protein; Provisional; Region: PRK06059
710685011118	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685011119	active site
710685011120	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
710685011121	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685011122	DNA polymerase I; Provisional; Region: PRK05755
710685011123	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
710685011124	active site
710685011125	metal binding site 1 [ion binding]; metal-binding site
710685011126	putative 5' ssDNA interaction site; other site
710685011127	metal binding site 3; metal-binding site
710685011128	metal binding site 2 [ion binding]; metal-binding site
710685011129	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
710685011130	putative DNA binding site [nucleotide binding]; other site
710685011131	putative metal binding site [ion binding]; other site
710685011132	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
710685011133	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
710685011134	active site
710685011135	DNA binding site [nucleotide binding]
710685011136	catalytic site [active]
710685011137	LysE type translocator; Region: LysE; cl00565
710685011138	Protease prsW family; Region: PrsW-protease; cl15823
710685011139	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
710685011140	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
710685011141	RNA binding site [nucleotide binding]; other site
710685011142	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
710685011143	RNA binding site [nucleotide binding]; other site
710685011144	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
710685011145	RNA binding site [nucleotide binding]; other site
710685011146	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692
710685011147	RNA binding site [nucleotide binding]; other site
710685011148	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
710685011149	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
710685011150	CoA-binding site [chemical binding]; other site
710685011151	ATP-binding [chemical binding]; other site
710685011152	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
710685011153	Protein of unknown function (DUF402); Region: DUF402; cl00979
710685011154	excinuclease ABC subunit B; Provisional; Region: PRK05298
710685011155	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685011156	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685011157	nucleotide binding region [chemical binding]; other site
710685011158	ATP-binding site [chemical binding]; other site
710685011159	Ultra-violet resistance protein B; Region: UvrB; pfam12344
710685011160	UvrB/uvrC motif; Region: UVR; pfam02151
710685011161	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685011162	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
710685011163	nucleosidase; Provisional; Region: PRK05634
710685011164	MgtC family; Region: MgtC; pfam02308
710685011165	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
710685011166	hydrophobic ligand binding site; other site
710685011167	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685011168	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685011169	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
710685011170	active site
710685011171	Fe-S cluster binding site [ion binding]; other site
710685011172	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
710685011173	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685011174	Ligand Binding Site [chemical binding]; other site
710685011175	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
710685011176	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
710685011177	putative active site [active]
710685011178	catalytic triad [active]
710685011179	putative dimer interface [polypeptide binding]; other site
710685011180	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
710685011181	catalytic residue [active]
710685011182	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685011183	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011184	short chain dehydrogenase; Provisional; Region: PRK08278
710685011185	NAD(P) binding site [chemical binding]; other site
710685011186	active site
710685011187	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685011188	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
710685011189	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
710685011190	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
710685011191	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
710685011192	Protein of unknown function (DUF1006); Region: DUF1006; cl15826
710685011193	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
710685011194	CHAT domain; Region: CHAT; pfam12770
710685011195	Putative esterase; Region: Esterase; pfam00756
710685011196	Predicted esterase [General function prediction only]; Region: COG0627
710685011197	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685011198	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
710685011199	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
710685011200	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
710685011201	dimer interface [polypeptide binding]; other site
710685011202	putative anticodon binding site; other site
710685011203	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
710685011204	motif 1; other site
710685011205	dimer interface [polypeptide binding]; other site
710685011206	active site
710685011207	motif 2; other site
710685011208	motif 3; other site
710685011209	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685011210	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
710685011211	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
710685011212	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
710685011213	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
710685011214	ribosomal protein L20; Region: rpl20; CHL00068
710685011215	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
710685011216	23S rRNA binding site [nucleotide binding]; other site
710685011217	L21 binding site [polypeptide binding]; other site
710685011218	L13 binding site [polypeptide binding]; other site
710685011219	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
710685011220	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
710685011221	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
710685011222	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
710685011223	classical (c) SDRs; Region: SDR_c; cd05233
710685011224	NAD(P) binding site [chemical binding]; other site
710685011225	active site
710685011226	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685011227	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685011228	active site
710685011229	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
710685011230	cyclase homology domain; Region: CHD; cd07302
710685011231	nucleotidyl binding site; other site
710685011232	metal binding site [ion binding]; metal-binding site
710685011233	dimer interface [polypeptide binding]; other site
710685011234	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
710685011235	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
710685011236	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
710685011237	dimer interface [polypeptide binding]; other site
710685011238	motif 1; other site
710685011239	active site
710685011240	motif 2; other site
710685011241	motif 3; other site
710685011242	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
710685011243	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
710685011244	putative tRNA-binding site [nucleotide binding]; other site
710685011245	B3/4 domain; Region: B3_4; cl11458
710685011246	tRNA synthetase B5 domain; Region: B5; cl08394
710685011247	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
710685011248	dimer interface [polypeptide binding]; other site
710685011249	motif 1; other site
710685011250	motif 3; other site
710685011251	motif 2; other site
710685011252	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
710685011253	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
710685011254	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
710685011255	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011256	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
710685011257	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
710685011258	heterotetramer interface [polypeptide binding]; other site
710685011259	active site pocket [active]
710685011260	cleavage site
710685011261	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
710685011262	feedback inhibition sensing region; other site
710685011263	homohexameric interface [polypeptide binding]; other site
710685011264	nucleotide binding site [chemical binding]; other site
710685011265	N-acetyl-L-glutamate binding site [chemical binding]; other site
710685011266	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
710685011267	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
710685011268	inhibitor-cofactor binding pocket; inhibition site
710685011269	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685011270	catalytic residue [active]
710685011271	ornithine carbamoyltransferase; Provisional; Region: PRK00779
710685011272	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
710685011273	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011274	arginine repressor; Provisional; Region: PRK03341
710685011275	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
710685011276	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
710685011277	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
710685011278	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
710685011279	ANP binding site [chemical binding]; other site
710685011280	Substrate Binding Site II [chemical binding]; other site
710685011281	Substrate Binding Site I [chemical binding]; other site
710685011282	argininosuccinate lyase; Provisional; Region: PRK00855
710685011283	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
710685011284	active sites [active]
710685011285	tetramer interface [polypeptide binding]; other site
710685011286	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
710685011287	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
710685011288	ABC transporter; Region: ABC_tran_2; pfam12848
710685011289	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
710685011290	acyl-CoA synthetase; Validated; Region: PRK07868
710685011291	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011292	Trm112p-like protein; Region: Trm112p; cl01066
710685011293	Helix-turn-helix domains; Region: HTH; cl00088
710685011294	ABC-2 type transporter; Region: ABC2_membrane; cl11417
710685011295	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
710685011296	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
710685011297	Walker A/P-loop; other site
710685011298	ATP binding site [chemical binding]; other site
710685011299	Q-loop/lid; other site
710685011300	ABC transporter signature motif; other site
710685011301	Walker B; other site
710685011302	D-loop; other site
710685011303	H-loop/switch region; other site
710685011304	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
710685011305	active site
710685011306	DNA binding site [nucleotide binding]
710685011307	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
710685011308	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
710685011309	active site
710685011310	HIGH motif; other site
710685011311	dimer interface [polypeptide binding]; other site
710685011312	KMSKS motif; other site
710685011313	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
710685011314	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
710685011315	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
710685011316	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685011317	active site
710685011318	motif I; other site
710685011319	motif II; other site
710685011320	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685011321	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
710685011322	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
710685011323	RNA binding surface [nucleotide binding]; other site
710685011324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
710685011325	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
710685011326	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
710685011327	DNA repair protein RecN; Region: recN; TIGR00634
710685011328	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685011329	Walker A/P-loop; other site
710685011330	ATP binding site [chemical binding]; other site
710685011331	Q-loop/lid; other site
710685011332	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
710685011333	ABC transporter signature motif; other site
710685011334	Walker B; other site
710685011335	D-loop; other site
710685011336	H-loop/switch region; other site
710685011337	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685011338	Helix-turn-helix domains; Region: HTH; cl00088
710685011339	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
710685011340	active site
710685011341	metal binding site [ion binding]; metal-binding site
710685011342	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685011343	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
710685011344	Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135
710685011345	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
710685011346	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
710685011347	CTP synthetase; Validated; Region: pyrG; PRK05380
710685011348	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
710685011349	Catalytic site [active]
710685011350	active site
710685011351	UTP binding site [chemical binding]; other site
710685011352	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
710685011353	active site
710685011354	putative oxyanion hole; other site
710685011355	catalytic triad [active]
710685011356	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
710685011357	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
710685011358	dimer interface [polypeptide binding]; other site
710685011359	ADP-ribose binding site [chemical binding]; other site
710685011360	active site
710685011361	nudix motif; other site
710685011362	metal binding site [ion binding]; metal-binding site
710685011363	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
710685011364	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685011365	active site
710685011366	DNA binding site [nucleotide binding]
710685011367	Int/Topo IB signature motif; other site
710685011368	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
710685011369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011370	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
710685011371	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
710685011372	P-loop; other site
710685011373	Magnesium ion binding site [ion binding]; other site
710685011374	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
710685011375	Magnesium ion binding site [ion binding]; other site
710685011376	ScpA/B protein; Region: ScpA_ScpB; cl00598
710685011377	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
710685011378	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
710685011379	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
710685011380	RNA binding surface [nucleotide binding]; other site
710685011381	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
710685011382	active site
710685011383	cytidylate kinase; Provisional; Region: cmk; PRK00023
710685011384	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
710685011385	CMP-binding site; other site
710685011386	The sites determining sugar specificity; other site
710685011387	GTP-binding protein Der; Reviewed; Region: PRK03003
710685011388	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
710685011389	G1 box; other site
710685011390	GTP/Mg2+ binding site [chemical binding]; other site
710685011391	Switch I region; other site
710685011392	G2 box; other site
710685011393	Switch II region; other site
710685011394	G3 box; other site
710685011395	G4 box; other site
710685011396	G5 box; other site
710685011397	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
710685011398	G1 box; other site
710685011399	GTP/Mg2+ binding site [chemical binding]; other site
710685011400	Switch I region; other site
710685011401	G2 box; other site
710685011402	G3 box; other site
710685011403	Switch II region; other site
710685011404	G4 box; other site
710685011405	G5 box; other site
710685011406	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
710685011407	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
710685011408	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
710685011409	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
710685011410	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
710685011411	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
710685011412	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
710685011413	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685011414	active site
710685011415	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
710685011416	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
710685011417	active site
710685011418	Transcriptional regulator [Transcription]; Region: IclR; COG1414
710685011419	Helix-turn-helix domains; Region: HTH; cl00088
710685011420	classical (c) SDRs; Region: SDR_c; cd05233
710685011421	NAD(P) binding site [chemical binding]; other site
710685011422	active site
710685011423	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
710685011424	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685011425	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685011426	enoyl-CoA hydratase; Provisional; Region: PRK07799
710685011427	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685011428	substrate binding site [chemical binding]; other site
710685011429	oxyanion hole (OAH) forming residues; other site
710685011430	trimer interface [polypeptide binding]; other site
710685011431	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685011432	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685011433	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
710685011434	anti sigma factor interaction site; other site
710685011435	regulatory phosphorylation site [posttranslational modification]; other site
710685011436	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
710685011437	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
710685011438	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
710685011439	peptide synthase; Provisional; Region: PRK12467
710685011440	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011441	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685011442	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685011443	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011444	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685011445	peptide synthase; Provisional; Region: PRK12316
710685011446	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685011447	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011448	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011449	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685011450	peptide synthase; Provisional; Region: PRK12467
710685011451	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685011452	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011453	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685011454	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685011455	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011456	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685011457	peptide synthase; Provisional; Region: PRK12316
710685011458	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685011459	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011460	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685011461	peptide synthase; Provisional; Region: PRK12467
710685011462	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685011463	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011464	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685011465	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685011466	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011467	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685011468	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
710685011469	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685011470	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011471	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685011472	peptide synthase; Provisional; Region: PRK12467
710685011473	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685011474	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011475	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685011476	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685011477	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011478	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685011479	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
710685011480	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685011481	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011482	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685011483	Acyltransferase family; Region: Acyl_transf_3; pfam01757
710685011484	Transport protein; Region: actII; TIGR00833
710685011485	Peptidase C80 family; Region: Peptidase_C80; pfam11713
710685011486	Cutinase; Region: Cutinase; pfam01083
710685011487	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
710685011488	Protein of unknown function (DUF732); Region: DUF732; pfam05305
710685011489	Transport protein; Region: actII; TIGR00833
710685011490	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
710685011491	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
710685011492	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
710685011493	Helix-turn-helix domains; Region: HTH; cl00088
710685011494	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685011495	classical (c) SDRs; Region: SDR_c; cd05233
710685011496	NAD(P) binding site [chemical binding]; other site
710685011497	active site
710685011498	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685011499	acyl-CoA synthetase; Provisional; Region: PRK13388
710685011500	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011501	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685011502	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685011503	[2Fe-2S] cluster binding site [ion binding]; other site
710685011504	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685011505	hydrophobic ligand binding site; other site
710685011506	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
710685011507	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685011508	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685011509	substrate binding site [chemical binding]; other site
710685011510	oxyanion hole (OAH) forming residues; other site
710685011511	trimer interface [polypeptide binding]; other site
710685011512	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685011513	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685011514	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685011515	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685011516	active site
710685011517	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
710685011518	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685011519	active site
710685011520	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685011521	classical (c) SDRs; Region: SDR_c; cd05233
710685011522	NAD(P) binding site [chemical binding]; other site
710685011523	active site
710685011524	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
710685011525	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
710685011526	tetramer interface [polypeptide binding]; other site
710685011527	TPP-binding site [chemical binding]; other site
710685011528	heterodimer interface [polypeptide binding]; other site
710685011529	phosphorylation loop region [posttranslational modification]
710685011530	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
710685011531	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
710685011532	alpha subunit interface [polypeptide binding]; other site
710685011533	TPP binding site [chemical binding]; other site
710685011534	heterodimer interface [polypeptide binding]; other site
710685011535	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
710685011536	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
710685011537	E3 interaction surface; other site
710685011538	lipoyl attachment site [posttranslational modification]; other site
710685011539	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685011540	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685011541	substrate binding site [chemical binding]; other site
710685011542	oxyanion hole (OAH) forming residues; other site
710685011543	trimer interface [polypeptide binding]; other site
710685011544	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
710685011545	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011546	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011547	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
710685011548	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
710685011549	NAD binding site [chemical binding]; other site
710685011550	catalytic Zn binding site [ion binding]; other site
710685011551	substrate binding site [chemical binding]; other site
710685011552	structural Zn binding site [ion binding]; other site
710685011553	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685011554	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
710685011555	[2Fe-2S] cluster binding site [ion binding]; other site
710685011556	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685011557	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685011558	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
710685011559	classical (c) SDRs; Region: SDR_c; cd05233
710685011560	NAD(P) binding site [chemical binding]; other site
710685011561	active site
710685011562	Transcriptional regulators [Transcription]; Region: FadR; COG2186
710685011563	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685011564	DNA-binding site [nucleotide binding]; DNA binding site
710685011565	FCD domain; Region: FCD; cl11656
710685011566	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685011567	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685011568	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685011569	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685011570	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685011571	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685011572	[2Fe-2S] cluster binding site [ion binding]; other site
710685011573	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685011574	hydrophobic ligand binding site; other site
710685011575	crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
710685011576	AMP-binding enzyme; Region: AMP-binding; cl15778
710685011577	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685011578	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685011579	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685011580	active site 2 [active]
710685011581	active site 1 [active]
710685011582	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
710685011583	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685011584	NAD binding site [chemical binding]; other site
710685011585	catalytic residues [active]
710685011586	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
710685011587	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
710685011588	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685011589	[2Fe-2S] cluster binding site [ion binding]; other site
710685011590	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
710685011591	putative alpha subunit interface [polypeptide binding]; other site
710685011592	putative active site [active]
710685011593	putative substrate binding site [chemical binding]; other site
710685011594	Fe binding site [ion binding]; other site
710685011595	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685011596	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
710685011597	active site
710685011598	catalytic triad [active]
710685011599	oxyanion hole [active]
710685011600	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
710685011601	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
710685011602	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
710685011603	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
710685011604	Helix-turn-helix domains; Region: HTH; cl00088
710685011605	Integrase core domain; Region: rve; cl01316
710685011606	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
710685011607	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685011608	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
710685011609	nudix motif; other site
710685011610	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685011611	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685011612	active site
710685011613	ATP binding site [chemical binding]; other site
710685011614	substrate binding site [chemical binding]; other site
710685011615	activation loop (A-loop); other site
710685011616	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
710685011617	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
710685011618	FMN-binding pocket [chemical binding]; other site
710685011619	flavin binding motif; other site
710685011620	phosphate binding motif [ion binding]; other site
710685011621	beta-alpha-beta structure motif; other site
710685011622	NAD binding pocket [chemical binding]; other site
710685011623	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685011624	catalytic loop [active]
710685011625	iron binding site [ion binding]; other site
710685011626	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
710685011627	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
710685011628	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
710685011629	putative acyl-acceptor binding pocket; other site
710685011630	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
710685011631	hydrophobic ligand binding site; other site
710685011632	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
710685011633	diaminopimelate decarboxylase; Region: lysA; TIGR01048
710685011634	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
710685011635	active site
710685011636	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
710685011637	substrate binding site [chemical binding]; other site
710685011638	catalytic residues [active]
710685011639	dimer interface [polypeptide binding]; other site
710685011640	Helix-turn-helix domains; Region: HTH; cl00088
710685011641	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011642	short chain dehydrogenase; Provisional; Region: PRK06197
710685011643	NAD(P) binding site [chemical binding]; other site
710685011644	active site
710685011645	Domain of unknown function (DUF202); Region: DUF202; cl09954
710685011646	Domain of unknown function (DUF202); Region: DUF202; cl09954
710685011647	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685011648	putative substrate translocation pore; other site
710685011649	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
710685011650	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
710685011651	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685011652	Helix-turn-helix domains; Region: HTH; cl00088
710685011653	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
710685011654	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
710685011655	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685011656	substrate binding pocket [chemical binding]; other site
710685011657	catalytic triad [active]
710685011658	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
710685011659	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011660	FAD dependent oxidoreductase; Region: DAO; pfam01266
710685011661	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685011662	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685011663	Helix-turn-helix domains; Region: HTH; cl00088
710685011664	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685011665	dimerization interface [polypeptide binding]; other site
710685011666	putative DNA binding site [nucleotide binding]; other site
710685011667	putative Zn2+ binding site [ion binding]; other site
710685011668	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
710685011669	putative hydrophobic ligand binding site [chemical binding]; other site
710685011670	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
710685011671	metal binding site [ion binding]; metal-binding site
710685011672	substrate binding site [chemical binding]; other site
710685011673	dimer interface [polypeptide binding]; other site
710685011674	hypothetical protein; Validated; Region: PRK07121
710685011675	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011676	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
710685011677	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
710685011678	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
710685011679	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011680	hypothetical protein; Provisional; Region: PRK06184
710685011681	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011682	hypothetical protein; Provisional; Region: PRK05858
710685011683	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
710685011684	PYR/PP interface [polypeptide binding]; other site
710685011685	dimer interface [polypeptide binding]; other site
710685011686	TPP binding site [chemical binding]; other site
710685011687	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
710685011688	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
710685011689	TPP-binding site; other site
710685011690	dimer interface [polypeptide binding]; other site
710685011691	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
710685011692	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
710685011693	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685011694	nucleotide binding region [chemical binding]; other site
710685011695	ATP-binding site [chemical binding]; other site
710685011696	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
710685011697	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
710685011698	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
710685011699	Protein of unknown function (DUF1290); Region: DUF1290; cl01587
710685011700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
710685011701	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
710685011702	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
710685011703	lipoyl attachment site [posttranslational modification]; other site
710685011704	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685011705	phosphopeptide binding site; other site
710685011706	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
710685011707	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
710685011708	DNA binding residues [nucleotide binding]
710685011709	Bifunctional nuclease; Region: DNase-RNase; cl00553
710685011710	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
710685011711	DNA binding residues [nucleotide binding]
710685011712	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
710685011713	putative dimer interface [polypeptide binding]; other site
710685011714	glycine dehydrogenase; Provisional; Region: PRK05367
710685011715	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
710685011716	tetramer interface [polypeptide binding]; other site
710685011717	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685011718	catalytic residue [active]
710685011719	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
710685011720	tetramer interface [polypeptide binding]; other site
710685011721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685011722	catalytic residue [active]
710685011723	haloalkane dehalogenase; Provisional; Region: PRK03204
710685011724	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685011725	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
710685011726	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685011727	metal ion-dependent adhesion site (MIDAS); other site
710685011728	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
710685011729	active site
710685011730	Domain of unknown function DUF21; Region: DUF21; pfam01595
710685011731	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
710685011732	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
710685011733	Domain of unknown function DUF21; Region: DUF21; pfam01595
710685011734	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
710685011735	Transporter associated domain; Region: CorC_HlyC; cl08393
710685011736	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
710685011737	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
710685011738	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
710685011739	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
710685011740	active site
710685011741	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011742	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
710685011743	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
710685011744	Peptidase family M48; Region: Peptidase_M48; cl12018
710685011745	Helix-turn-helix domains; Region: HTH; cl00088
710685011746	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685011747	CoenzymeA binding site [chemical binding]; other site
710685011748	subunit interaction site [polypeptide binding]; other site
710685011749	PHB binding site; other site
710685011750	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
710685011751	alpha-gamma subunit interface [polypeptide binding]; other site
710685011752	beta-gamma subunit interface [polypeptide binding]; other site
710685011753	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
710685011754	alpha-beta subunit interface [polypeptide binding]; other site
710685011755	urease subunit alpha; Reviewed; Region: ureC; PRK13206
710685011756	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
710685011757	subunit interactions [polypeptide binding]; other site
710685011758	active site
710685011759	flap region; other site
710685011760	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
710685011761	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685011762	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
710685011763	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685011764	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685011765	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
710685011766	short chain dehydrogenase; Provisional; Region: PRK12939
710685011767	classical (c) SDRs; Region: SDR_c; cd05233
710685011768	NAD(P) binding site [chemical binding]; other site
710685011769	active site
710685011770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685011771	dimer interface [polypeptide binding]; other site
710685011772	conserved gate region; other site
710685011773	putative PBP binding loops; other site
710685011774	ABC-ATPase subunit interface; other site
710685011775	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
710685011776	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685011777	Walker A/P-loop; other site
710685011778	ATP binding site [chemical binding]; other site
710685011779	Q-loop/lid; other site
710685011780	ABC transporter signature motif; other site
710685011781	Walker B; other site
710685011782	D-loop; other site
710685011783	H-loop/switch region; other site
710685011784	TOBE domain; Region: TOBE_2; cl01440
710685011785	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
710685011786	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
710685011787	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
710685011788	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
710685011789	putative NAD(P) binding site [chemical binding]; other site
710685011790	putative substrate binding site [chemical binding]; other site
710685011791	catalytic Zn binding site [ion binding]; other site
710685011792	structural Zn binding site [ion binding]; other site
710685011793	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
710685011794	CGNR zinc finger; Region: zf-CGNR; pfam11706
710685011795	CAAX protease self-immunity; Region: Abi; cl00558
710685011796	putative phosphoketolase; Provisional; Region: PRK05261
710685011797	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
710685011798	TPP-binding site; other site
710685011799	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
710685011800	XFP C-terminal domain; Region: XFP_C; pfam09363
710685011801	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685011802	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
710685011803	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685011804	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685011805	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685011806	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685011807	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685011808	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
710685011809	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685011810	active site
710685011811	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
710685011812	classical (c) SDRs; Region: SDR_c; cd05233
710685011813	NAD(P) binding site [chemical binding]; other site
710685011814	active site
710685011815	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
710685011816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011817	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685011818	Protein of unknown function DUF72; Region: DUF72; cl00777
710685011819	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
710685011820	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
710685011821	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685011822	Walker A motif; other site
710685011823	ATP binding site [chemical binding]; other site
710685011824	Walker B motif; other site
710685011825	arginine finger; other site
710685011826	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
710685011827	Predicted esterase [General function prediction only]; Region: COG0627
710685011828	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685011829	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
710685011830	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
710685011831	active site
710685011832	substrate binding site [chemical binding]; other site
710685011833	FMN binding site [chemical binding]; other site
710685011834	putative catalytic residues [active]
710685011835	Mechanosensitive ion channel; Region: MS_channel; pfam00924
710685011836	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
710685011837	ligand binding site [chemical binding]; other site
710685011838	flexible hinge region; other site
710685011839	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
710685011840	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
710685011841	dimerization interface [polypeptide binding]; other site
710685011842	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
710685011843	cyclase homology domain; Region: CHD; cd07302
710685011844	nucleotidyl binding site; other site
710685011845	metal binding site [ion binding]; metal-binding site
710685011846	dimer interface [polypeptide binding]; other site
710685011847	Protein of unknown function (DUF1810); Region: DUF1810; cl02370
710685011848	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
710685011849	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
710685011850	active site
710685011851	catalytic site [active]
710685011852	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
710685011853	nucleoside/Zn binding site; other site
710685011854	dimer interface [polypeptide binding]; other site
710685011855	catalytic motif [active]
710685011856	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685011857	CoenzymeA binding site [chemical binding]; other site
710685011858	subunit interaction site [polypeptide binding]; other site
710685011859	PHB binding site; other site
710685011860	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
710685011861	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
710685011862	nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486
710685011863	thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887
710685011864	NHLP leader peptide domain; Region: TOMM_pelo; cl15464
710685011865	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
710685011866	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685011867	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685011868	phenylacetate degradation probable enoyl-CoA hydratase paaB; Region: PaaB1; TIGR02280
710685011869	substrate binding site [chemical binding]; other site
710685011870	oxyanion hole (OAH) forming residues; other site
710685011871	trimer interface [polypeptide binding]; other site
710685011872	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
710685011873	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
710685011874	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
710685011875	heme binding site [chemical binding]; other site
710685011876	ferroxidase pore; other site
710685011877	ferroxidase diiron center [ion binding]; other site
710685011878	Major Facilitator Superfamily; Region: MFS_1; pfam07690
710685011879	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685011880	putative substrate translocation pore; other site
710685011881	CHASE3 domain; Region: CHASE3; cl05000
710685011882	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
710685011883	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
710685011884	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
710685011885	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
710685011886	anti sigma factor interaction site; other site
710685011887	regulatory phosphorylation site [posttranslational modification]; other site
710685011888	Uncharacterized conserved protein [Function unknown]; Region: COG2128
710685011889	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
710685011890	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
710685011891	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685011892	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
710685011893	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685011894	active site
710685011895	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685011896	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011897	NAD(P) binding site [chemical binding]; other site
710685011898	active site
710685011899	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
710685011900	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685011901	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
710685011902	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
710685011903	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
710685011904	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
710685011905	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
710685011906	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011907	Bacterial sugar transferase; Region: Bac_transf; cl00939
710685011908	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
710685011909	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
710685011910	active site
710685011911	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
710685011912	active site
710685011913	catalytic triad [active]
710685011914	oxyanion hole [active]
710685011915	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
710685011916	active site
710685011917	catalytic triad [active]
710685011918	oxyanion hole [active]
710685011919	Chain length determinant protein; Region: Wzz; cl15801
710685011920	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
710685011921	Chain length determinant protein; Region: Wzz; cl15801
710685011922	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
710685011923	Glycosyl hydrolase family 71; Region: Glyco_hydro_71; pfam03659
710685011924	Secretory lipase; Region: LIP; pfam03583
710685011925	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
710685011926	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
710685011927	putative ADP-binding pocket [chemical binding]; other site
710685011928	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
710685011929	putative trimer interface [polypeptide binding]; other site
710685011930	putative active site [active]
710685011931	putative substrate binding site [chemical binding]; other site
710685011932	putative CoA binding site [chemical binding]; other site
710685011933	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
710685011934	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
710685011935	NADP binding site [chemical binding]; other site
710685011936	active site
710685011937	putative substrate binding site [chemical binding]; other site
710685011938	GDP-mannose 4,6-dehydratase; Region: PLN02653
710685011939	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
710685011940	NADP-binding site; other site
710685011941	homotetramer interface [polypeptide binding]; other site
710685011942	substrate binding site [chemical binding]; other site
710685011943	homodimer interface [polypeptide binding]; other site
710685011944	active site
710685011945	putative glycosyl transferase; Provisional; Region: PRK10307
710685011946	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
710685011947	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
710685011948	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685011949	motif II; other site
710685011950	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685011951	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685011952	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685011953	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685011954	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685011955	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
710685011956	hydrophobic ligand binding site; other site
710685011957	probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854
710685011958	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685011959	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
710685011960	catalytic residues [active]
710685011961	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
710685011962	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
710685011963	Helix-turn-helix domains; Region: HTH; cl00088
710685011964	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
710685011965	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
710685011966	Coenzyme A binding pocket [chemical binding]; other site
710685011967	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
710685011968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
710685011969	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685011970	S-adenosylmethionine binding site [chemical binding]; other site
710685011971	benzoate transport; Region: 2A0115; TIGR00895
710685011972	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685011973	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685011974	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685011975	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685011976	Helix-turn-helix domains; Region: HTH; cl00088
710685011977	Protein of unknown function, DUF393; Region: DUF393; cl01136
710685011978	Arginase family; Region: Arginase; cl00306
710685011979	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
710685011980	active site
710685011981	serine racemase; Region: PLN02970
710685011982	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
710685011983	tetramer interface [polypeptide binding]; other site
710685011984	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685011985	catalytic residue [active]
710685011986	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
710685011987	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
710685011988	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
710685011989	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
710685011990	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
710685011991	Transcriptional regulators [Transcription]; Region: FadR; COG2186
710685011992	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685011993	DNA-binding site [nucleotide binding]; DNA binding site
710685011994	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
710685011995	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
710685011996	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
710685011997	non-specific DNA binding site [nucleotide binding]; other site
710685011998	salt bridge; other site
710685011999	sequence-specific DNA binding site [nucleotide binding]; other site
710685012000	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685012001	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
710685012002	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
710685012003	Helix-turn-helix domains; Region: HTH; cl00088
710685012004	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
710685012005	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
710685012006	molybdopterin cofactor binding site; other site
710685012007	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
710685012008	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
710685012009	putative molybdopterin cofactor binding site; other site
710685012010	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
710685012011	Helix-turn-helix domains; Region: HTH; cl00088
710685012012	Nitronate monooxygenase; Region: NMO; pfam03060
710685012013	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
710685012014	FMN binding site [chemical binding]; other site
710685012015	substrate binding site [chemical binding]; other site
710685012016	putative catalytic residue [active]
710685012017	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685012018	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
710685012019	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685012020	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012021	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012022	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685012023	NAD(P) binding site [chemical binding]; other site
710685012024	active site
710685012025	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685012026	CoenzymeA binding site [chemical binding]; other site
710685012027	subunit interaction site [polypeptide binding]; other site
710685012028	PHB binding site; other site
710685012029	competence damage-inducible protein A; Provisional; Region: PRK00549
710685012030	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
710685012031	Competence-damaged protein; Region: CinA; cl00666
710685012032	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685012033	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685012034	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
710685012035	AMP-binding enzyme; Region: AMP-binding; cl15778
710685012036	Protein of unknown function (DUF328); Region: DUF328; cl01143
710685012037	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
710685012038	NlpC/P60 family; Region: NLPC_P60; cl11438
710685012039	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
710685012040	Helix-turn-helix domains; Region: HTH; cl00088
710685012041	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
710685012042	cyclase homology domain; Region: CHD; cd07302
710685012043	nucleotidyl binding site; other site
710685012044	metal binding site [ion binding]; metal-binding site
710685012045	dimer interface [polypeptide binding]; other site
710685012046	Predicted ATPase [General function prediction only]; Region: COG3899
710685012047	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685012048	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685012049	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685012050	dimerization interface [polypeptide binding]; other site
710685012051	putative DNA binding site [nucleotide binding]; other site
710685012052	putative Zn2+ binding site [ion binding]; other site
710685012053	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
710685012054	putative hydrophobic ligand binding site [chemical binding]; other site
710685012055	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
710685012056	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685012057	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
710685012058	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
710685012059	active site
710685012060	TDP-binding site; other site
710685012061	acceptor substrate-binding pocket; other site
710685012062	homodimer interface [polypeptide binding]; other site
710685012063	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
710685012064	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
710685012065	catalytic triad [active]
710685012066	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
710685012067	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
710685012068	heme binding site [chemical binding]; other site
710685012069	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
710685012070	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
710685012071	metal binding site 2 [ion binding]; metal-binding site
710685012072	putative DNA binding helix; other site
710685012073	metal binding site 1 [ion binding]; metal-binding site
710685012074	dimer interface [polypeptide binding]; other site
710685012075	structural Zn2+ binding site [ion binding]; other site
710685012076	OpgC protein; Region: OpgC_C; cl00792
710685012077	Acyltransferase family; Region: Acyl_transf_3; pfam01757
710685012078	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
710685012079	active site
710685012080	catalytic triad [active]
710685012081	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
710685012082	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685012083	dimer interface [polypeptide binding]; other site
710685012084	phosphorylation site [posttranslational modification]
710685012085	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685012086	ATP binding site [chemical binding]; other site
710685012087	Mg2+ binding site [ion binding]; other site
710685012088	G-X-G motif; other site
710685012089	haloalkane dehalogenase; Provisional; Region: PRK00870
710685012090	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685012091	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
710685012092	tetramer interface [polypeptide binding]; other site
710685012093	active site
710685012094	Mg2+/Mn2+ binding site [ion binding]; other site
710685012095	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
710685012096	hydroxyglutarate oxidase; Provisional; Region: PRK11728
710685012097	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012098	NlpC/P60 family; Region: NLPC_P60; cl11438
710685012099	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
710685012100	AMP-binding enzyme; Region: AMP-binding; cl15778
710685012101	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685012102	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685012103	active site
710685012104	DJ-1 family protein; Region: not_thiJ; TIGR01383
710685012105	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
710685012106	conserved cys residue [active]
710685012107	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
710685012108	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
710685012109	MOSC domain; Region: MOSC; pfam03473
710685012110	3-alpha domain; Region: 3-alpha; pfam03475
710685012111	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
710685012112	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685012113	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685012114	active site
710685012115	ATP binding site [chemical binding]; other site
710685012116	substrate binding site [chemical binding]; other site
710685012117	activation loop (A-loop); other site
710685012118	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
710685012119	DinB superfamily; Region: DinB_2; pfam12867
710685012120	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
710685012121	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685012122	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685012123	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685012124	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
710685012125	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685012126	putative substrate translocation pore; other site
710685012127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685012128	peptide synthase; Provisional; Region: PRK12467
710685012129	AMP-binding enzyme; Region: AMP-binding; cl15778
710685012130	AMP-binding enzyme; Region: AMP-binding; cl15778
710685012131	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685012132	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
710685012133	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685012134	OpgC protein; Region: OpgC_C; cl00792
710685012135	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
710685012136	AMP-binding enzyme; Region: AMP-binding; cl15778
710685012137	AMP-binding enzyme; Region: AMP-binding; cl15778
710685012138	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685012139	Condensation domain; Region: Condensation; pfam00668
710685012140	peptide synthase; Provisional; Region: PRK12316
710685012141	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685012142	AMP-binding enzyme; Region: AMP-binding; cl15778
710685012143	AMP-binding enzyme; Region: AMP-binding; cl15778
710685012144	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685012145	peptide synthase; Provisional; Region: PRK12316
710685012146	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
710685012147	AMP-binding enzyme; Region: AMP-binding; cl15778
710685012148	AMP-binding enzyme; Region: AMP-binding; cl15778
710685012149	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685012150	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
710685012151	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
710685012152	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
710685012153	putative hydrophobic ligand binding site [chemical binding]; other site
710685012154	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
710685012155	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685012156	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685012157	Helix-turn-helix domains; Region: HTH; cl00088
710685012158	WYL domain; Region: WYL; cl14852
710685012159	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
710685012160	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
710685012161	TM1410 hypothetical-related protein; Region: DUF297; cl00997
710685012162	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
710685012163	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
710685012164	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012165	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685012166	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685012167	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012168	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685012169	Walker A/P-loop; other site
710685012170	ATP binding site [chemical binding]; other site
710685012171	Q-loop/lid; other site
710685012172	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
710685012173	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685012174	ABC transporter signature motif; other site
710685012175	Walker B; other site
710685012176	D-loop; other site
710685012177	H-loop/switch region; other site
710685012178	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685012179	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
710685012180	Walker A/P-loop; other site
710685012181	ATP binding site [chemical binding]; other site
710685012182	Q-loop/lid; other site
710685012183	ABC transporter signature motif; other site
710685012184	Walker B; other site
710685012185	D-loop; other site
710685012186	H-loop/switch region; other site
710685012187	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685012188	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
710685012189	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685012190	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
710685012191	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685012192	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
710685012193	Phosphate-starvation-inducible E; Region: PsiE; cl01264
710685012194	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
710685012195	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012196	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331
710685012197	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
710685012198	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685012199	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685012200	Sodium:solute symporter family; Region: SSF; cl00456
710685012201	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
710685012202	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685012203	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
710685012204	hydrophobic ligand binding site; other site
710685012205	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
710685012206	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685012207	Walker A/P-loop; other site
710685012208	ATP binding site [chemical binding]; other site
710685012209	Q-loop/lid; other site
710685012210	ABC transporter signature motif; other site
710685012211	Walker B; other site
710685012212	D-loop; other site
710685012213	H-loop/switch region; other site
710685012214	TOBE domain; Region: TOBE_2; cl01440
710685012215	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
710685012216	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685012217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685012218	dimer interface [polypeptide binding]; other site
710685012219	conserved gate region; other site
710685012220	putative PBP binding loops; other site
710685012221	ABC-ATPase subunit interface; other site
710685012222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685012223	dimer interface [polypeptide binding]; other site
710685012224	conserved gate region; other site
710685012225	putative PBP binding loops; other site
710685012226	ABC-ATPase subunit interface; other site
710685012227	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
710685012228	Transcriptional regulator [Transcription]; Region: LysR; COG0583
710685012229	Helix-turn-helix domains; Region: HTH; cl00088
710685012230	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685012231	dimerization interface [polypeptide binding]; other site
710685012232	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685012233	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
710685012234	N- and C-terminal domain interface [polypeptide binding]; other site
710685012235	D-xylulose kinase; Region: XylB; TIGR01312
710685012236	active site
710685012237	MgATP binding site [chemical binding]; other site
710685012238	catalytic site [active]
710685012239	metal binding site [ion binding]; metal-binding site
710685012240	carbohydrate binding site [chemical binding]; other site
710685012241	DoxX; Region: DoxX; cl00976
710685012242	RDD family; Region: RDD; cl00746
710685012243	GntP family permease; Region: GntP_permease; pfam02447
710685012244	Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264
710685012245	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
710685012246	Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265
710685012247	ATP-binding site [chemical binding]; other site
710685012248	Gluconate-6-phosphate binding site [chemical binding]; other site
710685012249	FCD domain; Region: FCD; cl11656
710685012250	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
710685012251	Helix-turn-helix domains; Region: HTH; cl00088
710685012252	Integrase core domain; Region: rve; cl01316
710685012253	Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
710685012254	Phosphotransferase enzyme family; Region: APH; pfam01636
710685012255	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685012256	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
710685012257	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685012258	substrate binding pocket [chemical binding]; other site
710685012259	catalytic triad [active]
710685012260	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
710685012261	Cation efflux family; Region: Cation_efflux; cl00316
710685012262	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685012263	dimerization interface [polypeptide binding]; other site
710685012264	putative DNA binding site [nucleotide binding]; other site
710685012265	putative Zn2+ binding site [ion binding]; other site
710685012266	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
710685012267	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
710685012268	active site
710685012269	dimer interface [polypeptide binding]; other site
710685012270	non-prolyl cis peptide bond; other site
710685012271	insertion regions; other site
710685012272	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
710685012273	substrate binding pocket [chemical binding]; other site
710685012274	membrane-bound complex binding site; other site
710685012275	hinge residues; other site
710685012276	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
710685012277	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
710685012278	Walker A/P-loop; other site
710685012279	ATP binding site [chemical binding]; other site
710685012280	Q-loop/lid; other site
710685012281	ABC transporter signature motif; other site
710685012282	Walker B; other site
710685012283	D-loop; other site
710685012284	H-loop/switch region; other site
710685012285	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
710685012286	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685012287	dimer interface [polypeptide binding]; other site
710685012288	conserved gate region; other site
710685012289	putative PBP binding loops; other site
710685012290	ABC-ATPase subunit interface; other site
710685012291	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
710685012292	DNA binding site [nucleotide binding]
710685012293	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685012294	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685012295	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
710685012296	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
710685012297	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
710685012298	Ligand binding site; other site
710685012299	Putative Catalytic site; other site
710685012300	DXD motif; other site
710685012301	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
710685012302	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
710685012303	putative active site [active]
710685012304	catalytic triad [active]
710685012305	putative dimer interface [polypeptide binding]; other site
710685012306	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
710685012307	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685012308	active site
710685012309	FxsA cytoplasmic membrane protein; Region: FxsA; cl01148
710685012310	Dienelactone hydrolase family; Region: DLH; pfam01738
710685012311	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685012312	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685012313	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
710685012314	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
710685012315	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
710685012316	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685012317	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012318	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
710685012319	NMT1-like family; Region: NMT1_2; cl15260
710685012320	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685012321	dimer interface [polypeptide binding]; other site
710685012322	conserved gate region; other site
710685012323	putative PBP binding loops; other site
710685012324	ABC-ATPase subunit interface; other site
710685012325	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
710685012326	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295
710685012327	Walker A/P-loop; other site
710685012328	ATP binding site [chemical binding]; other site
710685012329	Q-loop/lid; other site
710685012330	ABC transporter signature motif; other site
710685012331	Walker B; other site
710685012332	D-loop; other site
710685012333	H-loop/switch region; other site
710685012334	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
710685012335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
710685012336	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
710685012337	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
710685012338	precorrin-3B synthase; Region: CobG; TIGR02435
710685012339	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
710685012340	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
710685012341	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
710685012342	Precorrin-8X methylmutase; Region: CbiC; pfam02570
710685012343	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
710685012344	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
710685012345	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
710685012346	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
710685012347	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685012348	substrate binding site [chemical binding]; other site
710685012349	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
710685012350	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
710685012351	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
710685012352	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
710685012353	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
710685012354	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
710685012355	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
710685012356	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
710685012357	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012358	NAD(P) binding site [chemical binding]; other site
710685012359	active site
710685012360	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685012361	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
710685012362	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
710685012363	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
710685012364	active site
710685012365	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
710685012366	dimer interface [polypeptide binding]; other site
710685012367	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685012368	metal binding site [ion binding]; metal-binding site
710685012369	5'-3' exonuclease; Region: 53EXOc; smart00475
710685012370	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
710685012371	active site
710685012372	metal binding site 1 [ion binding]; metal-binding site
710685012373	putative 5' ssDNA interaction site; other site
710685012374	metal binding site 3; metal-binding site
710685012375	metal binding site 2 [ion binding]; metal-binding site
710685012376	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
710685012377	putative DNA binding site [nucleotide binding]; other site
710685012378	putative metal binding site [ion binding]; other site
710685012379	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
710685012380	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
710685012381	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
710685012382	ATP binding site [chemical binding]; other site
710685012383	putative Mg++ binding site [ion binding]; other site
710685012384	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685012385	nucleotide binding region [chemical binding]; other site
710685012386	ATP-binding site [chemical binding]; other site
710685012387	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
710685012388	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
710685012389	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
710685012390	Predicted transcriptional regulator [Transcription]; Region: COG2378
710685012391	WYL domain; Region: WYL; cl14852
710685012392	Predicted transcriptional regulator [Transcription]; Region: COG2378
710685012393	WYL domain; Region: WYL; cl14852
710685012394	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685012395	S-adenosylmethionine binding site [chemical binding]; other site
710685012396	Pup-ligase protein; Region: Pup_ligase; cl15463
710685012397	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
710685012398	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685012399	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685012400	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
710685012401	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
710685012402	active site
710685012403	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
710685012404	active site
710685012405	Pup-like protein; Region: Pup; cl05289
710685012406	Pup-ligase protein; Region: Pup_ligase; cl15463
710685012407	Protein of unknown function (DUF732); Region: DUF732; pfam05305
710685012408	proteasome ATPase; Region: pup_AAA; TIGR03689
710685012409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685012410	Walker A motif; other site
710685012411	ATP binding site [chemical binding]; other site
710685012412	Walker B motif; other site
710685012413	arginine finger; other site
710685012414	Protein of unknown function (DUF503); Region: DUF503; cl00669
710685012415	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
710685012416	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685012417	S-adenosylmethionine binding site [chemical binding]; other site
710685012418	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
710685012419	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
710685012420	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
710685012421	mercuric reductase; Validated; Region: PRK06370
710685012422	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012423	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685012424	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
710685012425	Predicted membrane protein [Function unknown]; Region: COG3918
710685012426	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
710685012427	ATP phosphoribosyltransferase; Region: HisG; cl15266
710685012428	HisG, C-terminal domain; Region: HisG_C; cl06867
710685012429	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
710685012430	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
710685012431	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685012432	putative substrate translocation pore; other site
710685012433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685012434	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
710685012435	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685012436	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685012437	motif II; other site
710685012438	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
710685012439	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
710685012440	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
710685012441	substrate binding pocket [chemical binding]; other site
710685012442	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
710685012443	B12 binding site [chemical binding]; other site
710685012444	cobalt ligand [ion binding]; other site
710685012445	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
710685012446	PAC2 family; Region: PAC2; cl00847
710685012447	Uncharacterized conserved protein [Function unknown]; Region: COG5361
710685012448	Protein of unknown function (DUF1254); Region: DUF1254; cl02257
710685012449	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
710685012450	short chain dehydrogenase; Provisional; Region: PRK05872
710685012451	classical (c) SDRs; Region: SDR_c; cd05233
710685012452	NAD(P) binding site [chemical binding]; other site
710685012453	active site
710685012454	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
710685012455	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
710685012456	active site
710685012457	HIGH motif; other site
710685012458	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
710685012459	active site
710685012460	KMSKS motif; other site
710685012461	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
710685012462	putative tRNA binding surface [nucleotide binding]; other site
710685012463	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
710685012464	active site
710685012465	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
710685012466	Protein of unknown function (DUF3090); Region: DUF3090; cl12832
710685012467	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
710685012468	catalytic core [active]
710685012469	Bacitracin resistance protein BacA; Region: BacA; cl00858
710685012470	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
710685012471	quinone interaction residues [chemical binding]; other site
710685012472	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
710685012473	active site
710685012474	catalytic residues [active]
710685012475	FMN binding site [chemical binding]; other site
710685012476	substrate binding site [chemical binding]; other site
710685012477	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
710685012478	substrate binding site [chemical binding]; other site
710685012479	hypothetical protein; Provisional; Region: PRK07906
710685012480	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
710685012481	putative metal binding site [ion binding]; other site
710685012482	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
710685012483	catalytic residues [active]
710685012484	catalytic nucleophile [active]
710685012485	Recombinase; Region: Recombinase; pfam07508
710685012486	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
710685012487	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
710685012488	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685012489	Creatinine amidohydrolase; Region: Creatininase; cl00618
710685012490	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
710685012491	Transposase; Region: DDE_Tnp_ISL3; pfam01610
710685012492	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685012493	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685012494	active site
710685012495	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
710685012496	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
710685012497	NAD binding site [chemical binding]; other site
710685012498	catalytic Zn binding site [ion binding]; other site
710685012499	substrate binding site [chemical binding]; other site
710685012500	structural Zn binding site [ion binding]; other site
710685012501	SCP-2 sterol transfer family; Region: SCP2; cl01225
710685012502	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
710685012503	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
710685012504	putative active site [active]
710685012505	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685012506	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685012507	active site
710685012508	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
710685012509	AMP-binding enzyme; Region: AMP-binding; cl15778
710685012510	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
710685012511	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685012512	Cytochrome P450; Region: p450; pfam00067
710685012513	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685012514	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012515	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685012516	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685012517	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685012518	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012519	classical (c) SDRs; Region: SDR_c; cd05233
710685012520	short chain dehydrogenase; Provisional; Region: PRK05650
710685012521	NAD(P) binding site [chemical binding]; other site
710685012522	active site
710685012523	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
710685012524	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
710685012525	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685012526	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
710685012527	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685012528	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685012529	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
710685012530	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
710685012531	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
710685012532	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
710685012533	carboxyltransferase (CT) interaction site; other site
710685012534	biotinylation site [posttranslational modification]; other site
710685012535	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685012536	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685012537	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
710685012538	active site
710685012539	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
710685012540	AMP-binding enzyme; Region: AMP-binding; cl15778
710685012541	AMP-binding enzyme; Region: AMP-binding; cl15778
710685012542	Helix-turn-helix domains; Region: HTH; cl00088
710685012543	tellurite resistance protein TehB; Provisional; Region: PRK12335
710685012544	TIGR03084 family protein; Region: TIGR03084
710685012545	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
710685012546	Wyosine base formation; Region: Wyosine_form; pfam08608
710685012547	enoyl-CoA hydratase; Provisional; Region: PRK06494
710685012548	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685012549	substrate binding site [chemical binding]; other site
710685012550	oxyanion hole (OAH) forming residues; other site
710685012551	trimer interface [polypeptide binding]; other site
710685012552	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685012553	active site 2 [active]
710685012554	active site 1 [active]
710685012555	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685012556	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685012557	active site 2 [active]
710685012558	active site 1 [active]
710685012559	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
710685012560	active site
710685012561	catalytic site [active]
710685012562	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685012563	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
710685012564	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685012565	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685012566	thiolase; Provisional; Region: PRK06158
710685012567	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685012568	active site
710685012569	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
710685012570	Uncharacterized ACR, COG1753; Region: DUF217; cl00762
710685012571	Helix-turn-helix domain; Region: HTH_18; pfam12833
710685012572	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685012573	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685012574	catalytic loop [active]
710685012575	iron binding site [ion binding]; other site
710685012576	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685012577	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
710685012578	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685012579	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685012580	Helix-turn-helix domains; Region: HTH; cl00088
710685012581	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685012582	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685012583	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685012584	CoenzymeA binding site [chemical binding]; other site
710685012585	subunit interaction site [polypeptide binding]; other site
710685012586	PHB binding site; other site
710685012587	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685012588	Helix-turn-helix domains; Region: HTH; cl00088
710685012589	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
710685012590	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685012591	active site
710685012592	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
710685012593	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012594	NAD(P) binding site [chemical binding]; other site
710685012595	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685012596	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685012597	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
710685012598	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
710685012599	D-pathway; other site
710685012600	Putative ubiquinol binding site [chemical binding]; other site
710685012601	Low-spin heme (heme b) binding site [chemical binding]; other site
710685012602	Putative water exit pathway; other site
710685012603	Binuclear center (heme o3/CuB) [ion binding]; other site
710685012604	K-pathway; other site
710685012605	Putative proton exit pathway; other site
710685012606	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
710685012607	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
710685012608	[4Fe-4S] binding site [ion binding]; other site
710685012609	molybdopterin cofactor binding site; other site
710685012610	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
710685012611	molybdopterin cofactor binding site; other site
710685012612	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
710685012613	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
710685012614	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
710685012615	FAD binding pocket [chemical binding]; other site
710685012616	FAD binding motif [chemical binding]; other site
710685012617	catalytic residues [active]
710685012618	NAD binding pocket [chemical binding]; other site
710685012619	phosphate binding motif [ion binding]; other site
710685012620	beta-alpha-beta structure motif; other site
710685012621	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
710685012622	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685012623	Ligand Binding Site [chemical binding]; other site
710685012624	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
710685012625	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
710685012626	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
710685012627	NMT1-like family; Region: NMT1_2; cl15260
710685012628	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
710685012629	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
710685012630	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685012631	ATP binding site [chemical binding]; other site
710685012632	Mg2+ binding site [ion binding]; other site
710685012633	G-X-G motif; other site
710685012634	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
710685012635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685012636	active site
710685012637	phosphorylation site [posttranslational modification]
710685012638	intermolecular recognition site; other site
710685012639	dimerization interface [polypeptide binding]; other site
710685012640	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685012641	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
710685012642	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
710685012643	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
710685012644	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
710685012645	substrate binding site [chemical binding]; other site
710685012646	active site
710685012647	catalytic residues [active]
710685012648	heterodimer interface [polypeptide binding]; other site
710685012649	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
710685012650	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
710685012651	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685012652	catalytic residue [active]
710685012653	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
710685012654	active site
710685012655	ribulose/triose binding site [chemical binding]; other site
710685012656	phosphate binding site [ion binding]; other site
710685012657	substrate (anthranilate) binding pocket [chemical binding]; other site
710685012658	product (indole) binding pocket [chemical binding]; other site
710685012659	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
710685012660	anthranilate synthase component I; Provisional; Region: PRK13571
710685012661	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
710685012662	chorismate binding enzyme; Region: Chorismate_bind; cl10555
710685012663	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
710685012664	catalytic triad [active]
710685012665	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685012666	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685012667	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
710685012668	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
710685012669	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
710685012670	substrate binding site [chemical binding]; other site
710685012671	glutamase interaction surface [polypeptide binding]; other site
710685012672	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
710685012673	active site
710685012674	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
710685012675	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
710685012676	catalytic residues [active]
710685012677	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
710685012678	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
710685012679	putative active site [active]
710685012680	oxyanion strand; other site
710685012681	catalytic triad [active]
710685012682	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
710685012683	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
710685012684	putative active site pocket [active]
710685012685	4-fold oligomerization interface [polypeptide binding]; other site
710685012686	metal binding residues [ion binding]; metal-binding site
710685012687	3-fold/trimer interface [polypeptide binding]; other site
710685012688	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
710685012689	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
710685012690	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685012691	homodimer interface [polypeptide binding]; other site
710685012692	catalytic residue [active]
710685012693	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
710685012694	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
710685012695	NAD binding site [chemical binding]; other site
710685012696	dimerization interface [polypeptide binding]; other site
710685012697	product binding site; other site
710685012698	substrate binding site [chemical binding]; other site
710685012699	zinc binding site [ion binding]; other site
710685012700	catalytic residues [active]
710685012701	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685012702	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012703	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
710685012704	NAD(P) binding site [chemical binding]; other site
710685012705	Helix-turn-helix domains; Region: HTH; cl00088
710685012706	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
710685012707	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
710685012708	dimerization interface [polypeptide binding]; other site
710685012709	active site
710685012710	L-aspartate oxidase; Provisional; Region: PRK07804
710685012711	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685012712	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
710685012713	Quinolinate synthetase A protein; Region: NadA; cl00420
710685012714	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
710685012715	nudix motif; other site
710685012716	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
710685012717	Secretory lipase; Region: LIP; pfam03583
710685012718	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
710685012719	biotin synthase; Validated; Region: PRK06256
710685012720	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
710685012721	FeS/SAM binding site; other site
710685012722	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
710685012723	tetracycline repressor protein TetR; Provisional; Region: PRK13756
710685012724	Helix-turn-helix domains; Region: HTH; cl00088
710685012725	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
710685012726	Protein of unknown function (DUF419); Region: DUF419; cl15265
710685012727	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
710685012728	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685012729	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
710685012730	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
710685012731	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
710685012732	catalytic residue [active]
710685012733	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
710685012734	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
710685012735	inhibitor-cofactor binding pocket; inhibition site
710685012736	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685012737	catalytic residue [active]
710685012738	OpgC protein; Region: OpgC_C; cl00792
710685012739	Acyltransferase family; Region: Acyl_transf_3; pfam01757
710685012740	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
710685012741	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
710685012742	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
710685012743	active site
710685012744	catalytic site [active]
710685012745	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
710685012746	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
710685012747	active site
710685012748	catalytic site [active]
710685012749	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
710685012750	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
710685012751	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
710685012752	catalytic site [active]
710685012753	active site
710685012754	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
710685012755	threonine dehydratase; Validated; Region: PRK08639
710685012756	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
710685012757	tetramer interface [polypeptide binding]; other site
710685012758	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685012759	catalytic residue [active]
710685012760	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
710685012761	putative Ile/Val binding site [chemical binding]; other site
710685012762	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685012763	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685012764	Leucine carboxyl methyltransferase; Region: LCM; cl01306
710685012765	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
710685012766	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
710685012767	tetramer interface [polypeptide binding]; other site
710685012768	active site
710685012769	Mg2+/Mn2+ binding site [ion binding]; other site
710685012770	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
710685012771	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
710685012772	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
710685012773	generic binding surface II; other site
710685012774	generic binding surface I; other site
710685012775	Uncharacterized conserved protein [Function unknown]; Region: COG2128
710685012776	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685012777	Helix-turn-helix domains; Region: HTH; cl00088
710685012778	Predicted permeases [General function prediction only]; Region: RarD; COG2962
710685012779	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
710685012780	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
710685012781	active site
710685012782	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
710685012783	lipoprotein signal peptidase; Provisional; Region: PRK14787
710685012784	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
710685012785	active site
710685012786	homodimer interface [polypeptide binding]; other site
710685012787	homotetramer interface [polypeptide binding]; other site
710685012788	DNA polymerase IV; Provisional; Region: PRK03348
710685012789	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
710685012790	active site
710685012791	DNA binding site [nucleotide binding]
710685012792	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
710685012793	dinuclear metal binding motif [ion binding]; other site
710685012794	coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024
710685012795	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
710685012796	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
710685012797	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
710685012798	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
710685012799	HIGH motif; other site
710685012800	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
710685012801	active site
710685012802	KMSKS motif; other site
710685012803	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
710685012804	tRNA binding surface [nucleotide binding]; other site
710685012805	anticodon binding site; other site
710685012806	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
710685012807	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
710685012808	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685012809	membrane ATPase/protein kinase; Provisional; Region: PRK09435
710685012810	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
710685012811	Walker A; other site
710685012812	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685012813	G4 box; other site
710685012814	G5 box; other site
710685012815	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
710685012816	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
710685012817	active site
710685012818	substrate binding site [chemical binding]; other site
710685012819	coenzyme B12 binding site [chemical binding]; other site
710685012820	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
710685012821	B12 binding site [chemical binding]; other site
710685012822	cobalt ligand [ion binding]; other site
710685012823	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
710685012824	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
710685012825	heterodimer interface [polypeptide binding]; other site
710685012826	substrate interaction site [chemical binding]; other site
710685012827	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
710685012828	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
710685012829	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685012830	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685012831	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
710685012832	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
710685012833	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
710685012834	ferrochelatase; Reviewed; Region: hemH; PRK00035
710685012835	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
710685012836	C-terminal domain interface [polypeptide binding]; other site
710685012837	active site
710685012838	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
710685012839	active site
710685012840	N-terminal domain interface [polypeptide binding]; other site
710685012841	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
710685012842	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
710685012843	NAD binding site [chemical binding]; other site
710685012844	homotetramer interface [polypeptide binding]; other site
710685012845	homodimer interface [polypeptide binding]; other site
710685012846	substrate binding site [chemical binding]; other site
710685012847	active site
710685012848	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
710685012849	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
710685012850	NAD(P) binding site [chemical binding]; other site
710685012851	homotetramer interface [polypeptide binding]; other site
710685012852	homodimer interface [polypeptide binding]; other site
710685012853	active site
710685012854	hypothetical protein; Provisional; Region: PRK13685
710685012855	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685012856	metal ion-dependent adhesion site (MIDAS); other site
710685012857	hypothetical protein; Provisional; Region: PRK13685
710685012858	Aerotolerance regulator N-terminal; Region: BatA; cl06567
710685012859	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685012860	metal ion-dependent adhesion site (MIDAS); other site
710685012861	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
710685012862	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685012863	MoxR-like ATPases [General function prediction only]; Region: COG0714
710685012864	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685012865	Walker A motif; other site
710685012866	ATP binding site [chemical binding]; other site
710685012867	Walker B motif; other site
710685012868	arginine finger; other site
710685012869	NlpC/P60 family; Region: NLPC_P60; cl11438
710685012870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
710685012871	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
710685012872	NlpC/P60 family; Region: NLPC_P60; cl11438
710685012873	aconitate hydratase; Validated; Region: PRK09277
710685012874	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
710685012875	substrate binding site [chemical binding]; other site
710685012876	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
710685012877	ligand binding site [chemical binding]; other site
710685012878	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
710685012879	substrate binding site [chemical binding]; other site
710685012880	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685012881	Helix-turn-helix domains; Region: HTH; cl00088
710685012882	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
710685012883	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685012884	Walker A/P-loop; other site
710685012885	ATP binding site [chemical binding]; other site
710685012886	Q-loop/lid; other site
710685012887	ABC transporter signature motif; other site
710685012888	Walker B; other site
710685012889	D-loop; other site
710685012890	H-loop/switch region; other site
710685012891	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
710685012892	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685012893	enoyl-CoA hydratase; Provisional; Region: PRK06688
710685012894	substrate binding site [chemical binding]; other site
710685012895	oxyanion hole (OAH) forming residues; other site
710685012896	trimer interface [polypeptide binding]; other site
710685012897	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
710685012898	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
710685012899	catalytic residues [active]
710685012900	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
710685012901	MOSC domain; Region: MOSC; pfam03473
710685012902	3-alpha domain; Region: 3-alpha; pfam03475
710685012903	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
710685012904	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
710685012905	FAD binding pocket [chemical binding]; other site
710685012906	FAD binding motif [chemical binding]; other site
710685012907	phosphate binding motif [ion binding]; other site
710685012908	beta-alpha-beta structure motif; other site
710685012909	NAD binding pocket [chemical binding]; other site
710685012910	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
710685012911	catalytic loop [active]
710685012912	iron binding site [ion binding]; other site
710685012913	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
710685012914	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
710685012915	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685012916	active site
710685012917	motif II; other site
710685012918	Domain of unknown function DUF59; Region: DUF59; cl00941
710685012919	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
710685012920	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
710685012921	trimerization site [polypeptide binding]; other site
710685012922	active site
710685012923	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
710685012924	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
710685012925	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
710685012926	catalytic residue [active]
710685012927	FeS assembly ATPase SufC; Region: sufC; TIGR01978
710685012928	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
710685012929	Walker A/P-loop; other site
710685012930	ATP binding site [chemical binding]; other site
710685012931	Q-loop/lid; other site
710685012932	ABC transporter signature motif; other site
710685012933	Walker B; other site
710685012934	D-loop; other site
710685012935	H-loop/switch region; other site
710685012936	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
710685012937	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
710685012938	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
710685012939	FeS assembly protein SufB; Region: sufB; TIGR01980
710685012940	Predicted transcriptional regulator [Transcription]; Region: COG2345
710685012941	Helix-turn-helix domains; Region: HTH; cl00088
710685012942	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
710685012943	Prostaglandin dehydrogenases; Region: PGDH; cd05288
710685012944	NAD(P) binding site [chemical binding]; other site
710685012945	substrate binding site [chemical binding]; other site
710685012946	dimer interface [polypeptide binding]; other site
710685012947	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
710685012948	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
710685012949	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
710685012950	Walker A/P-loop; other site
710685012951	ATP binding site [chemical binding]; other site
710685012952	Q-loop/lid; other site
710685012953	ABC transporter signature motif; other site
710685012954	Walker B; other site
710685012955	D-loop; other site
710685012956	H-loop/switch region; other site
710685012957	ABC-2 type transporter; Region: ABC2_membrane; cl11417
710685012958	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685012959	Helix-turn-helix domains; Region: HTH; cl00088
710685012960	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
710685012961	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685012962	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
710685012963	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
710685012964	NADP binding site [chemical binding]; other site
710685012965	dimer interface [polypeptide binding]; other site
710685012966	UbiA prenyltransferase family; Region: UbiA; cl00337
710685012967	transketolase; Reviewed; Region: PRK05899
710685012968	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
710685012969	TPP-binding site [chemical binding]; other site
710685012970	dimer interface [polypeptide binding]; other site
710685012971	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
710685012972	PYR/PP interface [polypeptide binding]; other site
710685012973	dimer interface [polypeptide binding]; other site
710685012974	TPP binding site [chemical binding]; other site
710685012975	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
710685012976	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
710685012977	putative active site [active]
710685012978	transaldolase; Provisional; Region: PRK03903
710685012979	catalytic residue [active]
710685012980	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
710685012981	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
710685012982	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
710685012983	opcA protein; Region: OpcA; TIGR00534
710685012984	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
710685012985	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
710685012986	putative active site [active]
710685012987	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685012988	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685012989	active site
710685012990	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685012991	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685012992	classical (c) SDRs; Region: SDR_c; cd05233
710685012993	NAD(P) binding site [chemical binding]; other site
710685012994	active site
710685012995	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685012996	Helix-turn-helix domains; Region: HTH; cl00088
710685012997	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
710685012998	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656
710685012999	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
710685013000	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
710685013001	substrate binding site [chemical binding]; other site
710685013002	dimer interface [polypeptide binding]; other site
710685013003	catalytic triad [active]
710685013004	Phosphoglycerate kinase; Region: PGK; pfam00162
710685013005	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
710685013006	substrate binding site [chemical binding]; other site
710685013007	hinge regions; other site
710685013008	ADP binding site [chemical binding]; other site
710685013009	catalytic site [active]
710685013010	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013011	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
710685013012	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
710685013013	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
710685013014	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
710685013015	substrate binding pocket [chemical binding]; other site
710685013016	membrane-bound complex binding site; other site
710685013017	hinge residues; other site
710685013018	cyclase homology domain; Region: CHD; cd07302
710685013019	nucleotidyl binding site; other site
710685013020	metal binding site [ion binding]; metal-binding site
710685013021	dimer interface [polypeptide binding]; other site
710685013022	Predicted ATPase [General function prediction only]; Region: COG3903
710685013023	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
710685013024	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
710685013025	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
710685013026	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
710685013027	phosphate binding site [ion binding]; other site
710685013028	putative substrate binding pocket [chemical binding]; other site
710685013029	dimer interface [polypeptide binding]; other site
710685013030	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
710685013031	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
710685013032	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
710685013033	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
710685013034	GIY-YIG motif/motif A; other site
710685013035	active site
710685013036	catalytic site [active]
710685013037	putative DNA binding site [nucleotide binding]; other site
710685013038	metal binding site [ion binding]; metal-binding site
710685013039	UvrB/uvrC motif; Region: UVR; pfam02151
710685013040	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
710685013041	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
710685013042	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
710685013043	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
710685013044	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
710685013045	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
710685013046	Coenzyme A binding pocket [chemical binding]; other site
710685013047	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
710685013048	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
710685013049	homopentamer interface [polypeptide binding]; other site
710685013050	active site
710685013051	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
710685013052	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
710685013053	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
710685013054	dimerization interface [polypeptide binding]; other site
710685013055	active site
710685013056	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
710685013057	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
710685013058	Lumazine binding domain; Region: Lum_binding; pfam00677
710685013059	Lumazine binding domain; Region: Lum_binding; pfam00677
710685013060	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
710685013061	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
710685013062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685013063	putative substrate translocation pore; other site
710685013064	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
710685013065	intracellular protease, PfpI family; Region: PfpI; TIGR01382
710685013066	proposed catalytic triad [active]
710685013067	conserved cys residue [active]
710685013068	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
710685013069	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
710685013070	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
710685013071	Walker A/P-loop; other site
710685013072	ATP binding site [chemical binding]; other site
710685013073	Q-loop/lid; other site
710685013074	ABC transporter signature motif; other site
710685013075	Walker B; other site
710685013076	D-loop; other site
710685013077	H-loop/switch region; other site
710685013078	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
710685013079	ligand binding site [chemical binding]; other site
710685013080	flexible hinge region; other site
710685013081	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
710685013082	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
710685013083	catalytic motif [active]
710685013084	Zn binding site [ion binding]; other site
710685013085	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
710685013086	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
710685013087	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
710685013088	substrate binding site [chemical binding]; other site
710685013089	hexamer interface [polypeptide binding]; other site
710685013090	metal binding site [ion binding]; metal-binding site
710685013091	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
710685013092	putative RNA binding site [nucleotide binding]; other site
710685013093	16S rRNA methyltransferase B; Provisional; Region: PRK14902
710685013094	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
710685013095	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
710685013096	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
710685013097	putative active site [active]
710685013098	substrate binding site [chemical binding]; other site
710685013099	putative cosubstrate binding site; other site
710685013100	catalytic site [active]
710685013101	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
710685013102	substrate binding site [chemical binding]; other site
710685013103	LemA family; Region: LemA; cl00742
710685013104	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
710685013105	primosome assembly protein PriA; Provisional; Region: PRK14873
710685013106	YhhN-like protein; Region: YhhN; cl01505
710685013107	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685013108	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685013109	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685013110	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013111	S-adenosylmethionine synthetase; Validated; Region: PRK05250
710685013112	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
710685013113	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
710685013114	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
710685013115	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
710685013116	Flavoprotein; Region: Flavoprotein; cl08021
710685013117	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
710685013118	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
710685013119	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
710685013120	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
710685013121	catalytic site [active]
710685013122	G-X2-G-X-G-K; other site
710685013123	Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827
710685013124	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
710685013125	active site
710685013126	dimer interface [polypeptide binding]; other site
710685013127	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
710685013128	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
710685013129	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685013130	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
710685013131	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
710685013132	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685013133	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
710685013134	IMP binding site; other site
710685013135	dimer interface [polypeptide binding]; other site
710685013136	interdomain contacts; other site
710685013137	partial ornithine binding site; other site
710685013138	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
710685013139	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
710685013140	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
710685013141	catalytic site [active]
710685013142	subunit interface [polypeptide binding]; other site
710685013143	dihydroorotase; Validated; Region: pyrC; PRK09357
710685013144	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685013145	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
710685013146	active site
710685013147	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
710685013148	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
710685013149	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013150	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
710685013151	active site
710685013152	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685013153	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013154	hypothetical protein; Provisional; Region: PRK07588
710685013155	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013156	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
710685013157	Helix-turn-helix domains; Region: HTH; cl00088
710685013158	Integrase core domain; Region: rve; cl01316
710685013159	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
710685013160	putative RNA binding site [nucleotide binding]; other site
710685013161	elongation factor P; Validated; Region: PRK00529
710685013162	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
710685013163	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
710685013164	RNA binding site [nucleotide binding]; other site
710685013165	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
710685013166	RNA binding site [nucleotide binding]; other site
710685013167	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
710685013168	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
710685013169	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
710685013170	active site
710685013171	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
710685013172	trimer interface [polypeptide binding]; other site
710685013173	active site
710685013174	dimer interface [polypeptide binding]; other site
710685013175	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
710685013176	active site
710685013177	dimer interface [polypeptide binding]; other site
710685013178	metal binding site [ion binding]; metal-binding site
710685013179	shikimate kinase; Reviewed; Region: aroK; PRK00131
710685013180	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
710685013181	ADP binding site [chemical binding]; other site
710685013182	magnesium binding site [ion binding]; other site
710685013183	putative shikimate binding site; other site
710685013184	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
710685013185	Tetramer interface [polypeptide binding]; other site
710685013186	active site
710685013187	FMN-binding site [chemical binding]; other site
710685013188	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
710685013189	nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486
710685013190	nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323
710685013191	NHLP leader peptide domain; Region: TOMM_pelo; cl15464
710685013192	nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486
710685013193	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
710685013194	Helix-turn-helix domains; Region: HTH; cl00088
710685013195	Protein of unknown function (DUF3237); Region: DUF3237; cl07905
710685013196	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685013197	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
710685013198	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
710685013199	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
710685013200	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
710685013201	shikimate binding site; other site
710685013202	NAD(P) binding site [chemical binding]; other site
710685013203	YceG-like family; Region: YceG; pfam02618
710685013204	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
710685013205	dimerization interface [polypeptide binding]; other site
710685013206	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
710685013207	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
710685013208	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
710685013209	motif 1; other site
710685013210	active site
710685013211	motif 2; other site
710685013212	motif 3; other site
710685013213	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
710685013214	DHHA1 domain; Region: DHHA1; pfam02272
710685013215	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
710685013216	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
710685013217	putative hydrophobic ligand binding site [chemical binding]; other site
710685013218	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685013219	putative DNA binding site [nucleotide binding]; other site
710685013220	putative Zn2+ binding site [ion binding]; other site
710685013221	recombination factor protein RarA; Reviewed; Region: PRK13342
710685013222	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685013223	Walker A motif; other site
710685013224	ATP binding site [chemical binding]; other site
710685013225	Walker B motif; other site
710685013226	arginine finger; other site
710685013227	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
710685013228	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
710685013229	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
710685013230	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
710685013231	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
710685013232	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
710685013233	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
710685013234	Uncharacterized conserved protein [Function unknown]; Region: COG2308
710685013235	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
710685013236	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
710685013237	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
710685013238	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
710685013239	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
710685013240	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
710685013241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
710685013242	Domain of unknown function (DUF389); Region: DUF389; cl00781
710685013243	Helix-turn-helix domains; Region: HTH; cl00088
710685013244	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
710685013245	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
710685013246	dimer interface [polypeptide binding]; other site
710685013247	active site
710685013248	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685013249	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013250	short chain dehydrogenase; Provisional; Region: PRK06197
710685013251	NAD(P) binding site [chemical binding]; other site
710685013252	active site
710685013253	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
710685013254	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
710685013255	dimer interface [polypeptide binding]; other site
710685013256	anticodon binding site; other site
710685013257	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
710685013258	homodimer interface [polypeptide binding]; other site
710685013259	motif 1; other site
710685013260	active site
710685013261	motif 2; other site
710685013262	GAD domain; Region: GAD; pfam02938
710685013263	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
710685013264	active site
710685013265	motif 3; other site
710685013266	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
710685013267	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013268	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
710685013269	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
710685013270	putative hydrophobic ligand binding site [chemical binding]; other site
710685013271	protein interface [polypeptide binding]; other site
710685013272	gate; other site
710685013273	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
710685013274	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685013275	substrate binding pocket [chemical binding]; other site
710685013276	catalytic triad [active]
710685013277	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
710685013278	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685013279	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685013280	classical (c) SDRs; Region: SDR_c; cd05233
710685013281	NAD(P) binding site [chemical binding]; other site
710685013282	active site
710685013283	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
710685013284	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
710685013285	active site
710685013286	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
710685013287	catalytic triad [active]
710685013288	dimer interface [polypeptide binding]; other site
710685013289	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685013290	Helix-turn-helix domains; Region: HTH; cl00088
710685013291	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685013292	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685013293	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685013294	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
710685013295	active site
710685013296	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685013297	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685013298	active site
710685013299	Transposase; Region: DEDD_Tnp_IS110; pfam01548
710685013300	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
710685013301	Radical SAM superfamily; Region: Radical_SAM; pfam04055
710685013302	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
710685013303	FeS/SAM binding site; other site
710685013304	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
710685013305	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
710685013306	homodimer interface [polypeptide binding]; other site
710685013307	active site
710685013308	TDP-binding site; other site
710685013309	acceptor substrate-binding pocket; other site
710685013310	probable selenate reductase, molybdenum-binding subunit; Region: Se_sel_red_Mo; TIGR03313
710685013311	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
710685013312	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
710685013313	putative ligand binding site [chemical binding]; other site
710685013314	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
710685013315	TM-ABC transporter signature motif; other site
710685013316	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
710685013317	TM-ABC transporter signature motif; other site
710685013318	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
710685013319	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
710685013320	Walker A/P-loop; other site
710685013321	ATP binding site [chemical binding]; other site
710685013322	Q-loop/lid; other site
710685013323	ABC transporter signature motif; other site
710685013324	Walker B; other site
710685013325	D-loop; other site
710685013326	H-loop/switch region; other site
710685013327	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
710685013328	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
710685013329	Walker A/P-loop; other site
710685013330	ATP binding site [chemical binding]; other site
710685013331	Q-loop/lid; other site
710685013332	ABC transporter signature motif; other site
710685013333	Walker B; other site
710685013334	D-loop; other site
710685013335	H-loop/switch region; other site
710685013336	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685013337	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
710685013338	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
710685013339	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
710685013340	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
710685013341	metal binding site [ion binding]; metal-binding site
710685013342	active site
710685013343	I-site; other site
710685013344	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
710685013345	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
710685013346	dimer interface [polypeptide binding]; other site
710685013347	motif 1; other site
710685013348	active site
710685013349	motif 2; other site
710685013350	motif 3; other site
710685013351	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
710685013352	anticodon binding site; other site
710685013353	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685013354	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
710685013355	active site
710685013356	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
710685013357	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
710685013358	active site
710685013359	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
710685013360	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
710685013361	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
710685013362	Zn2+ binding site [ion binding]; other site
710685013363	Mg2+ binding site [ion binding]; other site
710685013364	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
710685013365	synthetase active site [active]
710685013366	NTP binding site [chemical binding]; other site
710685013367	metal binding site [ion binding]; metal-binding site
710685013368	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
710685013369	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
710685013370	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
710685013371	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
710685013372	active site
710685013373	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
710685013374	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
710685013375	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
710685013376	Protein export membrane protein; Region: SecD_SecF; cl14618
710685013377	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
710685013378	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
710685013379	Protein export membrane protein; Region: SecD_SecF; cl14618
710685013380	Preprotein translocase subunit; Region: YajC; cl00806
710685013381	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
710685013382	active site
710685013383	metal binding site [ion binding]; metal-binding site
710685013384	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
710685013385	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
710685013386	inhibitor-cofactor binding pocket; inhibition site
710685013387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685013388	catalytic residue [active]
710685013389	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685013390	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
710685013391	tetrameric interface [polypeptide binding]; other site
710685013392	NAD binding site [chemical binding]; other site
710685013393	catalytic residues [active]
710685013394	substrate binding site [chemical binding]; other site
710685013395	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685013396	Helix-turn-helix domains; Region: HTH; cl00088
710685013397	Transcriptional regulators [Transcription]; Region: MarR; COG1846
710685013398	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
710685013399	AMP-binding enzyme; Region: AMP-binding; cl15778
710685013400	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685013401	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
710685013402	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013403	NAD(P) binding site [chemical binding]; other site
710685013404	active site
710685013405	Protein of unknown function (DUF1304); Region: DUF1304; cl01533
710685013406	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
710685013407	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
710685013408	Walker A motif; other site
710685013409	ATP binding site [chemical binding]; other site
710685013410	Walker B motif; other site
710685013411	arginine finger; other site
710685013412	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
710685013413	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
710685013414	RuvA N terminal domain; Region: RuvA_N; pfam01330
710685013415	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
710685013416	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
710685013417	active site
710685013418	putative DNA-binding cleft [nucleotide binding]; other site
710685013419	dimer interface [polypeptide binding]; other site
710685013420	Mechanosensitive ion channel; Region: MS_channel; pfam00924
710685013421	Transcriptional regulator; Region: Transcrip_reg; cl00361
710685013422	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685013423	Helix-turn-helix domains; Region: HTH; cl00088
710685013424	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
710685013425	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
710685013426	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685013427	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685013428	active site
710685013429	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
710685013430	imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855
710685013431	predicted active site [active]
710685013432	catalytic triad [active]
710685013433	acyl-CoA thioesterase II; Region: tesB; TIGR00189
710685013434	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
710685013435	active site
710685013436	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
710685013437	catalytic triad [active]
710685013438	dimer interface [polypeptide binding]; other site
710685013439	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
710685013440	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
710685013441	active site
710685013442	multimer interface [polypeptide binding]; other site
710685013443	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
710685013444	nudix motif; other site
710685013445	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
710685013446	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
710685013447	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
710685013448	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685013449	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
710685013450	putative acyl-acceptor binding pocket; other site
710685013451	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
710685013452	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
710685013453	nucleotide binding site/active site [active]
710685013454	HIT family signature motif; other site
710685013455	catalytic residue [active]
710685013456	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
710685013457	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
710685013458	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
710685013459	active site
710685013460	dimer interface [polypeptide binding]; other site
710685013461	motif 1; other site
710685013462	motif 2; other site
710685013463	motif 3; other site
710685013464	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
710685013465	anticodon binding site; other site
710685013466	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
710685013467	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685013468	CoenzymeA binding site [chemical binding]; other site
710685013469	subunit interaction site [polypeptide binding]; other site
710685013470	PHB binding site; other site
710685013471	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
710685013472	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
710685013473	active site
710685013474	catalytic tetrad [active]
710685013475	Domain of unknown function (DUF1990); Region: DUF1990; cl01969
710685013476	GAF domain; Region: GAF_2; pfam13185
710685013477	ANTAR domain; Region: ANTAR; cl04297
710685013478	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
710685013479	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
710685013480	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
710685013481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685013482	putative substrate translocation pore; other site
710685013483	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685013484	Protein of unknown function (DUF1469); Region: DUF1469; cl12095
710685013485	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
710685013486	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
710685013487	GAF domain; Region: GAF_2; pfam13185
710685013488	GAF domain; Region: GAF; cl15785
710685013489	ANTAR domain; Region: ANTAR; cl04297
710685013490	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
710685013491	Helix-turn-helix domain; Region: HTH_18; pfam12833
710685013492	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685013493	hydrophobic ligand binding site; other site
710685013494	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
710685013495	Clp amino terminal domain; Region: Clp_N; pfam02861
710685013496	Clp amino terminal domain; Region: Clp_N; pfam02861
710685013497	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
710685013498	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685013499	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685013500	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
710685013501	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
710685013502	DNA binding site [nucleotide binding]
710685013503	active site
710685013504	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685013505	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
710685013506	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685013507	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
710685013508	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685013509	Walker A motif; other site
710685013510	ATP binding site [chemical binding]; other site
710685013511	Walker B motif; other site
710685013512	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
710685013513	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
710685013514	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685013515	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
710685013516	Phosphotransferase enzyme family; Region: APH; pfam01636
710685013517	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685013518	Double zinc ribbon; Region: DZR; pfam12773
710685013519	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
710685013520	cyclase homology domain; Region: CHD; cd07302
710685013521	nucleotidyl binding site; other site
710685013522	metal binding site [ion binding]; metal-binding site
710685013523	dimer interface [polypeptide binding]; other site
710685013524	Predicted ATPase [General function prediction only]; Region: COG3899
710685013525	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685013526	Tetratricopeptide repeat; Region: TPR_12; pfam13424
710685013527	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685013528	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685013529	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685013530	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685013531	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
710685013532	SelR domain; Region: SelR; pfam01641
710685013533	malate dehydrogenase; Provisional; Region: PRK13529
710685013534	Malic enzyme, N-terminal domain; Region: malic; pfam00390
710685013535	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013536	NAD(P) binding pocket [chemical binding]; other site
710685013537	Chlorite dismutase; Region: Chlor_dismutase; cl01280
710685013538	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
710685013539	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013540	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
710685013541	substrate binding site [chemical binding]; other site
710685013542	active site
710685013543	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
710685013544	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
710685013545	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
710685013546	catalytic site [active]
710685013547	putative active site [active]
710685013548	putative substrate binding site [chemical binding]; other site
710685013549	HRDC domain; Region: HRDC; cl02578
710685013550	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685013551	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
710685013552	putative active site [active]
710685013553	putative metal binding site [ion binding]; other site
710685013554	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
710685013555	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
710685013556	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
710685013557	TPP-binding site; other site
710685013558	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
710685013559	PYR/PP interface [polypeptide binding]; other site
710685013560	dimer interface [polypeptide binding]; other site
710685013561	TPP binding site [chemical binding]; other site
710685013562	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
710685013563	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
710685013564	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685013565	TRAM domain; Region: TRAM; cl01282
710685013566	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
710685013567	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
710685013568	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
710685013569	Hypothetical protein; Provisional; Region: PHA02866
710685013570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013571	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013572	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
710685013573	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
710685013574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685013575	putative substrate translocation pore; other site
710685013576	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
710685013577	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
710685013578	generic binding surface II; other site
710685013579	ssDNA binding site; other site
710685013580	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
710685013581	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
710685013582	trimer interface [polypeptide binding]; other site
710685013583	active site
710685013584	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
710685013585	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
710685013586	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
710685013587	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
710685013588	active site
710685013589	dimerization interface [polypeptide binding]; other site
710685013590	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
710685013591	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
710685013592	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
710685013593	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685013594	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
710685013595	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685013596	DNA binding residues [nucleotide binding]
710685013597	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
710685013598	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685013599	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
710685013600	DNA binding residues [nucleotide binding]
710685013601	TOBE domain; Region: TOBE_2; cl01440
710685013602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
710685013603	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
710685013604	homotrimer interaction site [polypeptide binding]; other site
710685013605	putative active site [active]
710685013606	Protein of unknown function (DUF952); Region: DUF952; cl01393
710685013607	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
710685013608	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
710685013609	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
710685013610	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
710685013611	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
710685013612	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685013613	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
710685013614	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685013615	DNA binding residues [nucleotide binding]
710685013616	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
710685013617	Helix-turn-helix domains; Region: HTH; cl00088
710685013618	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
710685013619	FeoA domain; Region: FeoA; cl00838
710685013620	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
710685013621	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
710685013622	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013623	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685013624	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
710685013625	PAC2 family; Region: PAC2; cl00847
710685013626	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685013627	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685013628	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
710685013629	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
710685013630	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
710685013631	ATP cone domain; Region: ATP-cone; pfam03477
710685013632	LexA repressor; Validated; Region: PRK00215
710685013633	Helix-turn-helix domains; Region: HTH; cl00088
710685013634	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
710685013635	Catalytic site [active]
710685013636	LGFP repeat; Region: LGFP; pfam08310
710685013637	LGFP repeat; Region: LGFP; pfam08310
710685013638	LGFP repeat; Region: LGFP; pfam08310
710685013639	LGFP repeat; Region: LGFP; pfam08310
710685013640	LGFP repeat; Region: LGFP; pfam08310
710685013641	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
710685013642	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
710685013643	HflX GTPase family; Region: HflX; cd01878
710685013644	G1 box; other site
710685013645	GTP/Mg2+ binding site [chemical binding]; other site
710685013646	Switch I region; other site
710685013647	G2 box; other site
710685013648	G3 box; other site
710685013649	Switch II region; other site
710685013650	G4 box; other site
710685013651	G5 box; other site
710685013652	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
710685013653	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
710685013654	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
710685013655	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685013656	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
710685013657	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
710685013658	active site
710685013659	metal binding site [ion binding]; metal-binding site
710685013660	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
710685013661	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
710685013662	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
710685013663	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
710685013664	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
710685013665	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
710685013666	FeS/SAM binding site; other site
710685013667	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
710685013668	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
710685013669	Walker A/P-loop; other site
710685013670	ATP binding site [chemical binding]; other site
710685013671	Q-loop/lid; other site
710685013672	ABC transporter signature motif; other site
710685013673	Walker B; other site
710685013674	D-loop; other site
710685013675	H-loop/switch region; other site
710685013676	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
710685013677	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
710685013678	substrate binding pocket [chemical binding]; other site
710685013679	membrane-bound complex binding site; other site
710685013680	hinge residues; other site
710685013681	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
710685013682	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685013683	dimer interface [polypeptide binding]; other site
710685013684	conserved gate region; other site
710685013685	putative PBP binding loops; other site
710685013686	ABC-ATPase subunit interface; other site
710685013687	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685013688	dimer interface [polypeptide binding]; other site
710685013689	conserved gate region; other site
710685013690	putative PBP binding loops; other site
710685013691	ABC-ATPase subunit interface; other site
710685013692	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
710685013693	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685013694	RecX family; Region: RecX; cl00936
710685013695	recombinase A; Provisional; Region: recA; PRK09354
710685013696	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
710685013697	hexamer interface [polypeptide binding]; other site
710685013698	Walker A motif; other site
710685013699	ATP binding site [chemical binding]; other site
710685013700	Walker B motif; other site
710685013701	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
710685013702	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
710685013703	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685013704	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
710685013705	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
710685013706	NifU-like domain; Region: NifU; cl00484
710685013707	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
710685013708	iron-sulfur cluster [ion binding]; other site
710685013709	[2Fe-2S] cluster binding site [ion binding]; other site
710685013710	Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068
710685013711	nickel binding site [ion binding]; other site
710685013712	HupF/HypC family; Region: HupF_HypC; cl00394
710685013713	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
710685013714	Acylphosphatase; Region: Acylphosphatase; cl00551
710685013715	HypF finger; Region: zf-HYPF; pfam07503
710685013716	HypF finger; Region: zf-HYPF; pfam07503
710685013717	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
710685013718	HupF/HypC family; Region: HupF_HypC; cl00394
710685013719	Hydrogenase formation hypA family; Region: HypD; cl12072
710685013720	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
710685013721	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
710685013722	dimerization interface [polypeptide binding]; other site
710685013723	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
710685013724	ATP binding site [chemical binding]; other site
710685013725	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
710685013726	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
710685013727	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
710685013728	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685013729	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
710685013730	PspA/IM30 family; Region: PspA_IM30; pfam04012
710685013731	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
710685013732	non-specific DNA binding site [nucleotide binding]; other site
710685013733	salt bridge; other site
710685013734	sequence-specific DNA binding site [nucleotide binding]; other site
710685013735	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
710685013736	bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308
710685013737	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
710685013738	Coenzyme A binding pocket [chemical binding]; other site
710685013739	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685013740	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
710685013741	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
710685013742	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685013743	classical (c) SDRs; Region: SDR_c; cd05233
710685013744	NAD(P) binding site [chemical binding]; other site
710685013745	active site
710685013746	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
710685013747	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685013748	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
710685013749	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
710685013750	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
710685013751	dimer interface [polypeptide binding]; other site
710685013752	active site
710685013753	catalytic residue [active]
710685013754	Thymidylate synthase complementing protein; Region: Thy1; cl03630
710685013755	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
710685013756	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
710685013757	nucleoside/Zn binding site; other site
710685013758	dimer interface [polypeptide binding]; other site
710685013759	catalytic motif [active]
710685013760	Protein of unknown function (DUF1006); Region: DUF1006; cl15826
710685013761	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
710685013762	folate binding site [chemical binding]; other site
710685013763	NADP+ binding site [chemical binding]; other site
710685013764	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
710685013765	dimerization interface [polypeptide binding]; other site
710685013766	active site
710685013767	Dienelactone hydrolase family; Region: DLH; pfam01738
710685013768	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
710685013769	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685013770	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685013771	active site
710685013772	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685013773	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685013774	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
710685013775	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
710685013776	dihydrodipicolinate reductase; Provisional; Region: PRK00048
710685013777	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013778	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
710685013779	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
710685013780	Helix-turn-helix domains; Region: HTH; cl00088
710685013781	alanine dehydrogenase; Region: alaDH; TIGR00518
710685013782	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
710685013783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013784	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
710685013785	SEC-C motif; Region: SEC-C; pfam02810
710685013786	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685013787	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
710685013788	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
710685013789	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
710685013790	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
710685013791	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
710685013792	RNase E interface [polypeptide binding]; other site
710685013793	trimer interface [polypeptide binding]; other site
710685013794	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
710685013795	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
710685013796	RNase E interface [polypeptide binding]; other site
710685013797	trimer interface [polypeptide binding]; other site
710685013798	active site
710685013799	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
710685013800	putative nucleic acid binding region [nucleotide binding]; other site
710685013801	G-X-X-G motif; other site
710685013802	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
710685013803	RNA binding site [nucleotide binding]; other site
710685013804	domain interface; other site
710685013805	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
710685013806	16S/18S rRNA binding site [nucleotide binding]; other site
710685013807	S13e-L30e interaction site [polypeptide binding]; other site
710685013808	25S rRNA binding site [nucleotide binding]; other site
710685013809	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
710685013810	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
710685013811	active site
710685013812	Riboflavin kinase; Region: Flavokinase; cl03312
710685013813	Helix-turn-helix domains; Region: HTH; cl00088
710685013814	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
710685013815	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
710685013816	FeoA domain; Region: FeoA; cl00838
710685013817	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685013818	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685013819	substrate binding pocket [chemical binding]; other site
710685013820	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
710685013821	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
710685013822	RNA binding site [nucleotide binding]; other site
710685013823	active site
710685013824	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
710685013825	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
710685013826	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
710685013827	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
710685013828	active site
710685013829	metal binding site [ion binding]; metal-binding site
710685013830	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
710685013831	Helix-turn-helix domains; Region: HTH; cl00088
710685013832	Predicted acyl esterases [General function prediction only]; Region: COG2936
710685013833	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
710685013834	Domain of unknown function (DUF1802); Region: DUF1802; cl01755
710685013835	Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349
710685013836	enoyl-CoA hydratase; Provisional; Region: PRK06190
710685013837	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685013838	substrate binding site [chemical binding]; other site
710685013839	oxyanion hole (OAH) forming residues; other site
710685013840	trimer interface [polypeptide binding]; other site
710685013841	putative efflux protein, MATE family; Region: matE; TIGR00797
710685013842	MatE; Region: MatE; cl10513
710685013843	MatE; Region: MatE; cl10513
710685013844	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
710685013845	DHH family; Region: DHH; pfam01368
710685013846	Ribosome-binding factor A; Region: RBFA; cl00542
710685013847	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
710685013848	translation initiation factor IF-2; Region: IF-2; TIGR00487
710685013849	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
710685013850	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
710685013851	G1 box; other site
710685013852	putative GEF interaction site [polypeptide binding]; other site
710685013853	GTP/Mg2+ binding site [chemical binding]; other site
710685013854	Switch I region; other site
710685013855	G2 box; other site
710685013856	G3 box; other site
710685013857	Switch II region; other site
710685013858	G4 box; other site
710685013859	G5 box; other site
710685013860	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
710685013861	Translation-initiation factor 2; Region: IF-2; pfam11987
710685013862	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
710685013863	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
710685013864	putative RNA binding cleft [nucleotide binding]; other site
710685013865	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
710685013866	NusA N-terminal domain; Region: NusA_N; pfam08529
710685013867	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
710685013868	RNA binding site [nucleotide binding]; other site
710685013869	homodimer interface [polypeptide binding]; other site
710685013870	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
710685013871	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
710685013872	G-X-X-G motif; other site
710685013873	ribosome maturation protein RimP; Reviewed; Region: PRK00092
710685013874	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
710685013875	Sm1 motif; other site
710685013876	D1 - D2 interaction site; other site
710685013877	D3 - B interaction site; other site
710685013878	Hfq - Hfq interaction site; other site
710685013879	RNA binding pocket [nucleotide binding]; other site
710685013880	Sm2 motif; other site
710685013881	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
710685013882	dinuclear metal binding motif [ion binding]; other site
710685013883	prolyl-tRNA synthetase; Provisional; Region: PRK09194
710685013884	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
710685013885	dimer interface [polypeptide binding]; other site
710685013886	motif 1; other site
710685013887	active site
710685013888	motif 2; other site
710685013889	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
710685013890	putative deacylase active site [active]
710685013891	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
710685013892	active site
710685013893	motif 3; other site
710685013894	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
710685013895	anticodon binding site; other site
710685013896	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
710685013897	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685013898	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685013899	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
710685013900	putative substrate translocation pore; other site
710685013901	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013902	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
710685013903	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
710685013904	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685013905	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
710685013906	catalytic triad [active]
710685013907	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
710685013908	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
710685013909	Walker A motif; other site
710685013910	homodimer interface [polypeptide binding]; other site
710685013911	ATP binding site [chemical binding]; other site
710685013912	hydroxycobalamin binding site [chemical binding]; other site
710685013913	Walker B motif; other site
710685013914	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
710685013915	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685013916	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
710685013917	metal ion-dependent adhesion site (MIDAS); other site
710685013918	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685013919	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
710685013920	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685013921	mycothione reductase; Reviewed; Region: PRK07846
710685013922	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685013923	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
710685013924	High-affinity nickel-transport protein; Region: NicO; cl00964
710685013925	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685013926	Helix-turn-helix domains; Region: HTH; cl00088
710685013927	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
710685013928	Predicted ATPase [General function prediction only]; Region: COG3903
710685013929	FAD dependent oxidoreductase; Region: DAO; pfam01266
710685013930	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
710685013931	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
710685013932	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
710685013933	Phosphotransferase enzyme family; Region: APH; pfam01636
710685013934	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
710685013935	active site
710685013936	ATP binding site [chemical binding]; other site
710685013937	substrate binding site [chemical binding]; other site
710685013938	dimer interface [polypeptide binding]; other site
710685013939	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685013940	dimerization interface [polypeptide binding]; other site
710685013941	putative DNA binding site [nucleotide binding]; other site
710685013942	putative Zn2+ binding site [ion binding]; other site
710685013943	Transcriptional regulators [Transcription]; Region: FadR; COG2186
710685013944	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685013945	DNA-binding site [nucleotide binding]; DNA binding site
710685013946	FCD domain; Region: FCD; cl11656
710685013947	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685013948	classical (c) SDRs; Region: SDR_c; cd05233
710685013949	NAD(P) binding site [chemical binding]; other site
710685013950	active site
710685013951	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685013952	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
710685013953	NAD(P) binding site [chemical binding]; other site
710685013954	catalytic residues [active]
710685013955	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
710685013956	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
710685013957	catalytic triad [active]
710685013958	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
710685013959	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
710685013960	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
710685013961	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
710685013962	Spore germination protein; Region: Spore_permease; cl15802
710685013963	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
710685013964	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
710685013965	active site
710685013966	dimer interface [polypeptide binding]; other site
710685013967	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
710685013968	Ligand Binding Site [chemical binding]; other site
710685013969	Molecular Tunnel; other site
710685013970	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
710685013971	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685013972	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685013973	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
710685013974	cobyric acid synthase; Provisional; Region: PRK00784
710685013975	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685013976	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685013977	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
710685013978	catalytic triad [active]
710685013979	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
710685013980	active site
710685013981	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
710685013982	Helix-turn-helix domains; Region: HTH; cl00088
710685013983	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
710685013984	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
710685013985	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
710685013986	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
710685013987	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685013988	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148
710685013989	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685013990	Predicted acetyltransferase [General function prediction only]; Region: COG3393
710685013991	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
710685013992	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
710685013993	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
710685013994	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
710685013995	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
710685013996	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
710685013997	active site
710685013998	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
710685013999	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
710685014000	putative substrate binding region [chemical binding]; other site
710685014001	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
710685014002	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
710685014003	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
710685014004	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
710685014005	Fasciclin domain; Region: Fasciclin; cl02663
710685014006	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
710685014007	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
710685014008	catalytic residues [active]
710685014009	Fasciclin domain; Region: Fasciclin; cl02663
710685014010	RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635
710685014011	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685014012	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
710685014013	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014014	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
710685014015	NAD(P) binding site [chemical binding]; other site
710685014016	active site
710685014017	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685014018	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
710685014019	SelR domain; Region: SelR; pfam01641
710685014020	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
710685014021	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685014022	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
710685014023	DNA photolyase; Region: DNA_photolyase; pfam00875
710685014024	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
710685014025	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685014026	classical (c) SDRs; Region: SDR_c; cd05233
710685014027	NAD(P) binding site [chemical binding]; other site
710685014028	active site
710685014029	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
710685014030	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685014031	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685014032	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
710685014033	Domain of unknown function (DUF427); Region: DUF427; cl00998
710685014034	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
710685014035	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685014036	active site
710685014037	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
710685014038	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685014039	Helix-turn-helix domains; Region: HTH; cl00088
710685014040	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
710685014041	active site
710685014042	metal binding site [ion binding]; metal-binding site
710685014043	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
710685014044	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685014045	active site
710685014046	metal binding site [ion binding]; metal-binding site
710685014047	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
710685014048	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
710685014049	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014050	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014051	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685014052	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
710685014053	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685014054	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685014055	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685014056	active site 2 [active]
710685014057	active site 1 [active]
710685014058	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685014059	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
710685014060	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685014061	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685014062	active site
710685014063	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
710685014064	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
710685014065	hydrophobic ligand binding site; other site
710685014066	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685014067	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685014068	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685014069	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685014070	classical (c) SDRs; Region: SDR_c; cd05233
710685014071	NAD(P) binding site [chemical binding]; other site
710685014072	active site
710685014073	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
710685014074	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
710685014075	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
710685014076	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014077	NAD(P) binding site [chemical binding]; other site
710685014078	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685014079	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
710685014080	Strictosidine synthase; Region: Str_synth; pfam03088
710685014081	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
710685014082	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
710685014083	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
710685014084	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685014085	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685014086	Helix-turn-helix domains; Region: HTH; cl00088
710685014087	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685014088	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
710685014089	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
710685014090	putative active site [active]
710685014091	putative substrate binding site [chemical binding]; other site
710685014092	ATP binding site [chemical binding]; other site
710685014093	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685014094	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685014095	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685014096	Helix-turn-helix domains; Region: HTH; cl00088
710685014097	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685014098	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
710685014099	NAD binding site [chemical binding]; other site
710685014100	catalytic residues [active]
710685014101	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685014102	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
710685014103	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
710685014104	FeS/SAM binding site; other site
710685014105	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
710685014106	ribosome recycling factor; Reviewed; Region: frr; PRK00083
710685014107	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
710685014108	hinge region; other site
710685014109	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
710685014110	putative nucleotide binding site [chemical binding]; other site
710685014111	uridine monophosphate binding site [chemical binding]; other site
710685014112	homohexameric interface [polypeptide binding]; other site
710685014113	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685014114	S-adenosylmethionine binding site [chemical binding]; other site
710685014115	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
710685014116	Helix-turn-helix domains; Region: HTH; cl00088
710685014117	Arginase family; Region: Arginase; cl00306
710685014118	Glycerate kinase family; Region: Gly_kinase; cl00841
710685014119	amidase; Provisional; Region: PRK07869
710685014120	Amidase; Region: Amidase; cl11426
710685014121	elongation factor Ts; Provisional; Region: tsf; PRK09377
710685014122	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
710685014123	Elongation factor TS; Region: EF_TS; pfam00889
710685014124	Elongation factor TS; Region: EF_TS; pfam00889
710685014125	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
710685014126	rRNA interaction site [nucleotide binding]; other site
710685014127	S8 interaction site; other site
710685014128	putative laminin-1 binding site; other site
710685014129	Peptidase family M23; Region: Peptidase_M23; pfam01551
710685014130	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
710685014131	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685014132	active site
710685014133	DNA binding site [nucleotide binding]
710685014134	Int/Topo IB signature motif; other site
710685014135	L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases.  It is thought...; Region: LMO_FMN; cd03332
710685014136	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
710685014137	putative active site [active]
710685014138	putative substrate binding site [chemical binding]; other site
710685014139	putative FMN binding site [chemical binding]; other site
710685014140	putative catalytic residues [active]
710685014141	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
710685014142	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
710685014143	FAD binding pocket [chemical binding]; other site
710685014144	FAD binding motif [chemical binding]; other site
710685014145	phosphate binding motif [ion binding]; other site
710685014146	NAD binding pocket [chemical binding]; other site
710685014147	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
710685014148	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
710685014149	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
710685014150	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
710685014151	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685014152	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
710685014153	Restriction endonuclease; Region: Mrr_cat; cl00516
710685014154	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
710685014155	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
710685014156	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
710685014157	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
710685014158	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
710685014159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685014160	dimer interface [polypeptide binding]; other site
710685014161	conserved gate region; other site
710685014162	ABC-ATPase subunit interface; other site
710685014163	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
710685014164	dimer interface [polypeptide binding]; other site
710685014165	conserved gate region; other site
710685014166	ABC-ATPase subunit interface; other site
710685014167	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
710685014168	ABC Carbohydrate and Solute Transporters-like subgroup.  This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols.  ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259
710685014169	Walker A/P-loop; other site
710685014170	ATP binding site [chemical binding]; other site
710685014171	Q-loop/lid; other site
710685014172	ABC transporter signature motif; other site
710685014173	Walker B; other site
710685014174	D-loop; other site
710685014175	H-loop/switch region; other site
710685014176	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
710685014177	AMP-binding enzyme; Region: AMP-binding; cl15778
710685014178	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685014179	Acyltransferase family; Region: Acyl_transf_3; pfam01757
710685014180	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685014181	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685014182	active site
710685014183	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
710685014184	acyl-CoA thioesterase II; Region: tesB; TIGR00189
710685014185	active site
710685014186	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
710685014187	catalytic triad [active]
710685014188	dimer interface [polypeptide binding]; other site
710685014189	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685014190	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685014191	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
710685014192	tetramer interface [polypeptide binding]; other site
710685014193	TPP-binding site [chemical binding]; other site
710685014194	heterodimer interface [polypeptide binding]; other site
710685014195	phosphorylation loop region [posttranslational modification]
710685014196	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
710685014197	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
710685014198	PYR/PP interface [polypeptide binding]; other site
710685014199	dimer interface [polypeptide binding]; other site
710685014200	TPP binding site [chemical binding]; other site
710685014201	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
710685014202	Arginase family; Region: Arginase; cl00306
710685014203	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685014204	UMP phosphatase; Provisional; Region: PRK10444
710685014205	active site
710685014206	motif I; other site
710685014207	motif II; other site
710685014208	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685014209	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
710685014210	Helix-turn-helix domains; Region: HTH; cl00088
710685014211	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
710685014212	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685014213	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014214	NAD(P) binding site [chemical binding]; other site
710685014215	active site
710685014216	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
710685014217	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
710685014218	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
710685014219	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685014220	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685014221	substrate binding site [chemical binding]; other site
710685014222	trimer interface [polypeptide binding]; other site
710685014223	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685014224	[2Fe-2S] cluster binding site [ion binding]; other site
710685014225	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
710685014226	alpha subunit interface [polypeptide binding]; other site
710685014227	active site
710685014228	substrate binding site [chemical binding]; other site
710685014229	Fe binding site [ion binding]; other site
710685014230	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685014231	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685014232	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
710685014233	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685014234	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685014235	Helix-turn-helix domains; Region: HTH; cl00088
710685014236	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685014237	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685014238	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
710685014239	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
710685014240	active site
710685014241	inhibitor site; inhibition site
710685014242	dimer interface [polypeptide binding]; other site
710685014243	catalytic residue [active]
710685014244	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685014245	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685014246	active site
710685014247	Helix-turn-helix domains; Region: HTH; cl00088
710685014248	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685014249	classical (c) SDRs; Region: SDR_c; cd05233
710685014250	NAD(P) binding site [chemical binding]; other site
710685014251	active site
710685014252	Uncharacterized conserved protein [Function unknown]; Region: COG2128
710685014253	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685014254	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685014255	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685014256	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685014257	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
710685014258	NAD binding site [chemical binding]; other site
710685014259	catalytic residues [active]
710685014260	short chain dehydrogenase; Provisional; Region: PRK06179
710685014261	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014262	NAD(P) binding site [chemical binding]; other site
710685014263	active site
710685014264	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
710685014265	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
710685014266	ligand binding site [chemical binding]; other site
710685014267	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685014268	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
710685014269	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
710685014270	metal ion-dependent adhesion site (MIDAS); other site
710685014271	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
710685014272	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685014273	active site
710685014274	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685014275	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685014276	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685014277	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
710685014278	FMN binding site [chemical binding]; other site
710685014279	dimer interface [polypeptide binding]; other site
710685014280	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685014281	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685014282	Helix-turn-helix domains; Region: HTH; cl00088
710685014283	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685014284	Helix-turn-helix domains; Region: HTH; cl00088
710685014285	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
710685014286	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
710685014287	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
710685014288	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
710685014289	ligand binding site [chemical binding]; other site
710685014290	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685014291	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685014292	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014293	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685014294	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014295	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
710685014296	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
710685014297	RNA/DNA hybrid binding site [nucleotide binding]; other site
710685014298	active site
710685014299	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
710685014300	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
710685014301	Catalytic site [active]
710685014302	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
710685014303	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
710685014304	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
710685014305	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685014306	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
710685014307	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
710685014308	RimM N-terminal domain; Region: RimM; pfam01782
710685014309	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
710685014310	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
710685014311	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
710685014312	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685014313	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685014314	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
710685014315	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685014316	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
710685014317	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
710685014318	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
710685014319	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
710685014320	active site
710685014321	signal recognition particle protein; Provisional; Region: PRK10867
710685014322	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
710685014323	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
710685014324	P loop; other site
710685014325	GTP binding site [chemical binding]; other site
710685014326	Signal peptide binding domain; Region: SRP_SPB; pfam02978
710685014327	PII uridylyl-transferase; Provisional; Region: PRK03381
710685014328	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
710685014329	metal binding triad; other site
710685014330	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
710685014331	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
710685014332	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
710685014333	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
710685014334	Nitrogen regulatory protein P-II; Region: P-II; cl00412
710685014335	Nitrogen regulatory protein P-II; Region: P-II; smart00938
710685014336	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
710685014337	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
710685014338	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
710685014339	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685014340	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
710685014341	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
710685014342	homotetramer interface [polypeptide binding]; other site
710685014343	FMN binding site [chemical binding]; other site
710685014344	homodimer contacts [polypeptide binding]; other site
710685014345	putative active site [active]
710685014346	putative substrate binding site [chemical binding]; other site
710685014347	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
710685014348	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
710685014349	Walker A/P-loop; other site
710685014350	ATP binding site [chemical binding]; other site
710685014351	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
710685014352	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
710685014353	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
710685014354	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
710685014355	ABC transporter signature motif; other site
710685014356	Walker B; other site
710685014357	D-loop; other site
710685014358	H-loop/switch region; other site
710685014359	Acylphosphatase; Region: Acylphosphatase; cl00551
710685014360	OsmC-like protein; Region: OsmC; cl00767
710685014361	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
710685014362	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
710685014363	DNA binding site [nucleotide binding]
710685014364	catalytic residue [active]
710685014365	H2TH interface [polypeptide binding]; other site
710685014366	putative catalytic residues [active]
710685014367	turnover-facilitating residue; other site
710685014368	intercalation triad [nucleotide binding]; other site
710685014369	8OG recognition residue [nucleotide binding]; other site
710685014370	putative reading head residues; other site
710685014371	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
710685014372	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
710685014373	ribonuclease III; Reviewed; Region: rnc; PRK00102
710685014374	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
710685014375	dimerization interface [polypeptide binding]; other site
710685014376	active site
710685014377	metal binding site [ion binding]; metal-binding site
710685014378	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
710685014379	dsRNA binding site [nucleotide binding]; other site
710685014380	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
710685014381	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
710685014382	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
710685014383	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
710685014384	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
710685014385	active site
710685014386	(T/H)XGH motif; other site
710685014387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685014388	S-adenosylmethionine binding site [chemical binding]; other site
710685014389	pyruvate carboxylase; Reviewed; Region: PRK12999
710685014390	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
710685014391	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685014392	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
710685014393	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
710685014394	active site
710685014395	catalytic residues [active]
710685014396	metal binding site [ion binding]; metal-binding site
710685014397	homodimer binding site [polypeptide binding]; other site
710685014398	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
710685014399	carboxyltransferase (CT) interaction site; other site
710685014400	biotinylation site [posttranslational modification]; other site
710685014401	Vitamin K epoxide reductase family; Region: VKOR; cl01729
710685014402	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
710685014403	catalytic residues [active]
710685014404	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685014405	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
710685014406	substrate binding pocket [chemical binding]; other site
710685014407	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685014408	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
710685014409	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
710685014410	active site
710685014411	catalytic tetrad [active]
710685014412	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
710685014413	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
710685014414	active site
710685014415	catalytic tetrad [active]
710685014416	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
710685014417	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
710685014418	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
710685014419	generic binding surface II; other site
710685014420	ssDNA binding site; other site
710685014421	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
710685014422	ATP binding site [chemical binding]; other site
710685014423	putative Mg++ binding site [ion binding]; other site
710685014424	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
710685014425	nucleotide binding region [chemical binding]; other site
710685014426	ATP-binding site [chemical binding]; other site
710685014427	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
710685014428	DAK2 domain; Region: Dak2; cl03685
710685014429	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
710685014430	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
710685014431	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
710685014432	ligand binding site [chemical binding]; other site
710685014433	active site
710685014434	UGI interface [polypeptide binding]; other site
710685014435	catalytic site [active]
710685014436	thiamine monophosphate kinase; Provisional; Region: PRK05731
710685014437	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
710685014438	ATP binding site [chemical binding]; other site
710685014439	dimerization interface [polypeptide binding]; other site
710685014440	Helix-turn-helix domains; Region: HTH; cl00088
710685014441	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
710685014442	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
710685014443	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
710685014444	ATP-grasp domain; Region: ATP-grasp_4; cl03087
710685014445	cystathionine gamma-lyase; Validated; Region: PRK07582
710685014446	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
710685014447	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
710685014448	catalytic residue [active]
710685014449	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
710685014450	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014451	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
710685014452	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
710685014453	polyphosphate kinase; Provisional; Region: PRK05443
710685014454	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
710685014455	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
710685014456	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
710685014457	putative domain interface [polypeptide binding]; other site
710685014458	putative active site [active]
710685014459	catalytic site [active]
710685014460	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
710685014461	putative active site [active]
710685014462	catalytic site [active]
710685014463	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
710685014464	active site
710685014465	Ap6A binding site [chemical binding]; other site
710685014466	nudix motif; other site
710685014467	metal binding site [ion binding]; metal-binding site
710685014468	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
710685014469	catalytic core [active]
710685014470	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
710685014471	IHF - DNA interface [nucleotide binding]; other site
710685014472	IHF dimer interface [polypeptide binding]; other site
710685014473	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
710685014474	substrate binding site [chemical binding]; other site
710685014475	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
710685014476	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
710685014477	substrate binding site [chemical binding]; other site
710685014478	ligand binding site [chemical binding]; other site
710685014479	Transcriptional regulator [Transcription]; Region: IclR; COG1414
710685014480	Helix-turn-helix domains; Region: HTH; cl00088
710685014481	Bacterial transcriptional regulator; Region: IclR; pfam01614
710685014482	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
710685014483	active site
710685014484	Erythromycin esterase homolog [General function prediction only]; Region: COG2312
710685014485	Erythromycin esterase; Region: Erythro_esteras; pfam05139
710685014486	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
710685014487	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
710685014488	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685014489	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685014490	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685014491	Ligand Binding Site [chemical binding]; other site
710685014492	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
710685014493	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685014494	Ligand Binding Site [chemical binding]; other site
710685014495	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685014496	Ligand Binding Site [chemical binding]; other site
710685014497	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
710685014498	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
710685014499	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685014500	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685014501	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685014502	Ligand Binding Site [chemical binding]; other site
710685014503	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685014504	Ligand Binding Site [chemical binding]; other site
710685014505	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685014506	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685014507	Ligand Binding Site [chemical binding]; other site
710685014508	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
710685014509	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
710685014510	HIGH motif; other site
710685014511	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
710685014512	active site
710685014513	KMSKS motif; other site
710685014514	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
710685014515	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
710685014516	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
710685014517	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685014518	putative substrate translocation pore; other site
710685014519	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
710685014520	tartrate dehydrogenase; Provisional; Region: PRK08194
710685014521	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
710685014522	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014523	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
710685014524	putative L-serine binding site [chemical binding]; other site
710685014525	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
710685014526	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014527	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
710685014528	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
710685014529	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
710685014530	DNA binding residues [nucleotide binding]
710685014531	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
710685014532	active site
710685014533	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
710685014534	ketol-acid reductoisomerase; Provisional; Region: PRK05479
710685014535	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014536	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
710685014537	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
710685014538	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
710685014539	putative valine binding site [chemical binding]; other site
710685014540	dimer interface [polypeptide binding]; other site
710685014541	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
710685014542	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
710685014543	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
710685014544	PYR/PP interface [polypeptide binding]; other site
710685014545	dimer interface [polypeptide binding]; other site
710685014546	TPP binding site [chemical binding]; other site
710685014547	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
710685014548	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
710685014549	TPP-binding site [chemical binding]; other site
710685014550	dimer interface [polypeptide binding]; other site
710685014551	Protein of unknown function (DUF983); Region: DUF983; cl02211
710685014552	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
710685014553	DoxX; Region: DoxX; cl00976
710685014554	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
710685014555	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
710685014556	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
710685014557	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
710685014558	GatB domain; Region: GatB_Yqey; cl11497
710685014559	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
710685014560	active site
710685014561	ADP/pyrophosphate binding site [chemical binding]; other site
710685014562	dimerization interface [polypeptide binding]; other site
710685014563	allosteric effector site; other site
710685014564	fructose-1,6-bisphosphate binding site; other site
710685014565	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
710685014566	Amidase; Region: Amidase; cl11426
710685014567	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
710685014568	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
710685014569	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
710685014570	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
710685014571	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
710685014572	nucleotide binding pocket [chemical binding]; other site
710685014573	K-X-D-G motif; other site
710685014574	catalytic site [active]
710685014575	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
710685014576	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
710685014577	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
710685014578	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
710685014579	Dimer interface [polypeptide binding]; other site
710685014580	BRCT sequence motif; other site
710685014581	Protein of unknown function (DUF419); Region: DUF419; cl15265
710685014582	4-coumarate--CoA ligase; Region: PLN02246
710685014583	AMP-binding enzyme; Region: AMP-binding; cl15778
710685014584	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685014585	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
710685014586	dimerization interface [polypeptide binding]; other site
710685014587	putative DNA binding site [nucleotide binding]; other site
710685014588	putative Zn2+ binding site [ion binding]; other site
710685014589	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898
710685014590	putative hydrophobic ligand binding site [chemical binding]; other site
710685014591	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
710685014592	PknH-like extracellular domain; Region: PknH_C; pfam14032
710685014593	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
710685014594	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
710685014595	Ligand Binding Site [chemical binding]; other site
710685014596	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
710685014597	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
710685014598	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
710685014599	catalytic residue [active]
710685014600	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
710685014601	putative acyl-acceptor binding pocket; other site
710685014602	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
710685014603	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
710685014604	putative FMN binding site [chemical binding]; other site
710685014605	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
710685014606	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
710685014607	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
710685014608	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
710685014609	Ligand binding site [chemical binding]; other site
710685014610	Electron transfer flavoprotein domain; Region: ETF; pfam01012
710685014611	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685014612	S-adenosylmethionine binding site [chemical binding]; other site
710685014613	Uncharacterized conserved protein [Function unknown]; Region: COG1543
710685014614	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
710685014615	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
710685014616	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
710685014617	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
710685014618	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685014619	substrate binding pocket [chemical binding]; other site
710685014620	catalytic triad [active]
710685014621	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
710685014622	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
710685014623	trimer interface [polypeptide binding]; other site
710685014624	active site
710685014625	substrate binding site [chemical binding]; other site
710685014626	CoA binding site [chemical binding]; other site
710685014627	FOG: WD40-like repeat [Function unknown]; Region: COG1520
710685014628	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
710685014629	active site
710685014630	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
710685014631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685014632	S-adenosylmethionine binding site [chemical binding]; other site
710685014633	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685014634	substrate binding site [chemical binding]; other site
710685014635	oxyanion hole (OAH) forming residues; other site
710685014636	trimer interface [polypeptide binding]; other site
710685014637	endoglucanase; Region: PLN02171
710685014638	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
710685014639	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685014640	Walker A/P-loop; other site
710685014641	ATP binding site [chemical binding]; other site
710685014642	Q-loop/lid; other site
710685014643	ABC transporter signature motif; other site
710685014644	Walker B; other site
710685014645	D-loop; other site
710685014646	H-loop/switch region; other site
710685014647	Predicted membrane protein [Function unknown]; Region: COG2364
710685014648	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
710685014649	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
710685014650	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685014651	DNA-binding site [nucleotide binding]; DNA binding site
710685014652	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
710685014653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
710685014654	homodimer interface [polypeptide binding]; other site
710685014655	catalytic residue [active]
710685014656	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
710685014657	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
710685014658	phosphoserine phosphatase SerB; Region: serB; TIGR00338
710685014659	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
710685014660	motif II; other site
710685014661	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
710685014662	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
710685014663	D-pathway; other site
710685014664	Putative ubiquinol binding site [chemical binding]; other site
710685014665	Low-spin heme (heme b) binding site [chemical binding]; other site
710685014666	Putative water exit pathway; other site
710685014667	Binuclear center (heme o3/CuB) [ion binding]; other site
710685014668	K-pathway; other site
710685014669	Putative proton exit pathway; other site
710685014670	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
710685014671	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
710685014672	siderophore binding site; other site
710685014673	YCII-related domain; Region: YCII; cl00999
710685014674	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
710685014675	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
710685014676	putative NAD(P) binding site [chemical binding]; other site
710685014677	putative substrate binding site [chemical binding]; other site
710685014678	catalytic Zn binding site [ion binding]; other site
710685014679	structural Zn binding site [ion binding]; other site
710685014680	dimer interface [polypeptide binding]; other site
710685014681	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
710685014682	GAF domain; Region: GAF; cl15785
710685014683	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
710685014684	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014685	Bacterial sugar transferase; Region: Bac_transf; cl00939
710685014686	Cutinase; Region: Cutinase; pfam01083
710685014687	EcsC protein family; Region: EcsC; pfam12787
710685014688	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685014689	active site
710685014690	ATP binding site [chemical binding]; other site
710685014691	substrate binding site [chemical binding]; other site
710685014692	activation loop (A-loop); other site
710685014693	PknH-like extracellular domain; Region: PknH_C; pfam14032
710685014694	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
710685014695	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
710685014696	dimer interface [polypeptide binding]; other site
710685014697	putative radical transfer pathway; other site
710685014698	diiron center [ion binding]; other site
710685014699	tyrosyl radical; other site
710685014700	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685014701	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014702	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
710685014703	Helix-turn-helix domains; Region: HTH; cl00088
710685014704	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
710685014705	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014706	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
710685014707	dimerization interface [polypeptide binding]; other site
710685014708	substrate binding pocket [chemical binding]; other site
710685014709	Predicted transcriptional regulator [Transcription]; Region: COG2345
710685014710	Helix-turn-helix domains; Region: HTH; cl00088
710685014711	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
710685014712	S-adenosylmethionine binding site [chemical binding]; other site
710685014713	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014714	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
710685014715	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
710685014716	Walker A/P-loop; other site
710685014717	ATP binding site [chemical binding]; other site
710685014718	Q-loop/lid; other site
710685014719	ABC transporter signature motif; other site
710685014720	Walker B; other site
710685014721	D-loop; other site
710685014722	H-loop/switch region; other site
710685014723	GIY-YIG domain of uncharacterized hypothetical protein found in phycodnavirus PBCV-1 DNA virus, T. thermophila Tlr element eoncoding protein Tlr8p, and similar proteins found in bacteria; Region: GIY-YIG_HE_Tlr8p_PBC-V_like; cd10443
710685014724	GIY-YIG motif/motif A; other site
710685014725	putative active site [active]
710685014726	putative metal binding site [ion binding]; other site
710685014727	GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl14912
710685014728	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
710685014729	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
710685014730	Class I ribonucleotide reductase; Region: RNR_I; cd01679
710685014731	active site
710685014732	dimer interface [polypeptide binding]; other site
710685014733	catalytic residues [active]
710685014734	effector binding site; other site
710685014735	R2 peptide binding site; other site
710685014736	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
710685014737	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
710685014738	catalytic residues [active]
710685014739	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
710685014740	Helix-turn-helix domains; Region: HTH; cl00088
710685014741	DNA polymerase IV; Validated; Region: PRK03352
710685014742	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
710685014743	active site
710685014744	DNA binding site [nucleotide binding]
710685014745	short chain dehydrogenase; Provisional; Region: PRK07832
710685014746	classical (c) SDRs; Region: SDR_c; cd05233
710685014747	NAD(P) binding site [chemical binding]; other site
710685014748	active site
710685014749	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685014750	Helix-turn-helix domains; Region: HTH; cl00088
710685014751	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685014752	Cytochrome P450; Region: p450; pfam00067
710685014753	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
710685014754	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
710685014755	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
710685014756	putative active site [active]
710685014757	putative substrate binding site [chemical binding]; other site
710685014758	ATP binding site [chemical binding]; other site
710685014759	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
710685014760	pyruvate dehydrogenase; Provisional; Region: PRK09124
710685014761	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
710685014762	PYR/PP interface [polypeptide binding]; other site
710685014763	tetramer interface [polypeptide binding]; other site
710685014764	dimer interface [polypeptide binding]; other site
710685014765	TPP binding site [chemical binding]; other site
710685014766	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
710685014767	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
710685014768	TPP-binding site [chemical binding]; other site
710685014769	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
710685014770	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014771	NAD(P) binding site [chemical binding]; other site
710685014772	active site
710685014773	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
710685014774	Moco binding site; other site
710685014775	metal coordination site [ion binding]; other site
710685014776	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
710685014777	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
710685014778	active site
710685014779	DNA binding site [nucleotide binding]
710685014780	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
710685014781	DNA binding site [nucleotide binding]
710685014782	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
710685014783	Predicted transcriptional regulator [Transcription]; Region: COG2345
710685014784	Helix-turn-helix domains; Region: HTH; cl00088
710685014785	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
710685014786	heme-binding site [chemical binding]; other site
710685014787	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
710685014788	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
710685014789	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
710685014790	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
710685014791	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
710685014792	[4Fe-4S] binding site [ion binding]; other site
710685014793	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
710685014794	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
710685014795	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
710685014796	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
710685014797	molybdopterin cofactor binding site; other site
710685014798	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685014799	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
710685014800	putative substrate translocation pore; other site
710685014801	carbon starvation protein A; Provisional; Region: PRK15015
710685014802	Carbon starvation protein CstA; Region: CstA; pfam02554
710685014803	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
710685014804	Protein of unknown function (DUF466); Region: DUF466; cl01082
710685014805	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
710685014806	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
710685014807	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
710685014808	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685014809	coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024
710685014810	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
710685014811	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
710685014812	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685014813	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
710685014814	probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857
710685014815	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685014816	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685014817	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685014818	Phosphotransferase enzyme family; Region: APH; pfam01636
710685014819	active site
710685014820	substrate binding site [chemical binding]; other site
710685014821	ATP binding site [chemical binding]; other site
710685014822	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685014823	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
710685014824	Helix-turn-helix domains; Region: HTH; cl00088
710685014825	Bacterial transcriptional repressor; Region: TetR_C_6; cl07106
710685014826	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685014827	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
710685014828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014829	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
710685014830	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
710685014831	homodimer interface [polypeptide binding]; other site
710685014832	putative substrate binding pocket [chemical binding]; other site
710685014833	diiron center [ion binding]; other site
710685014834	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
710685014835	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685014836	[2Fe-2S] cluster binding site [ion binding]; other site
710685014837	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
710685014838	catalytic triad [active]
710685014839	conserved cis-peptide bond; other site
710685014840	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685014841	CoenzymeA binding site [chemical binding]; other site
710685014842	subunit interaction site [polypeptide binding]; other site
710685014843	PHB binding site; other site
710685014844	acyl-CoA synthetase; Validated; Region: PRK07798
710685014845	AMP-binding enzyme; Region: AMP-binding; cl15778
710685014846	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
710685014847	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
710685014848	NAD(P) binding site [chemical binding]; other site
710685014849	catalytic residues [active]
710685014850	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014851	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
710685014852	NAD(P) binding site [chemical binding]; other site
710685014853	active site
710685014854	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685014855	tetracycline repressor protein TetR; Provisional; Region: PRK13756
710685014856	Helix-turn-helix domains; Region: HTH; cl00088
710685014857	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685014858	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685014859	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
710685014860	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
710685014861	molybdopterin cofactor binding site; other site
710685014862	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
710685014863	molybdopterin cofactor binding site; other site
710685014864	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
710685014865	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685014866	active site
710685014867	classical (c) SDRs; Region: SDR_c; cd05233
710685014868	NAD(P) binding site [chemical binding]; other site
710685014869	active site
710685014870	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685014871	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
710685014872	classical (c) SDRs; Region: SDR_c; cd05233
710685014873	NAD(P) binding site [chemical binding]; other site
710685014874	active site
710685014875	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
710685014876	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
710685014877	putative NADP binding site [chemical binding]; other site
710685014878	putative substrate binding site [chemical binding]; other site
710685014879	active site
710685014880	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685014881	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685014882	active site
710685014883	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685014884	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685014885	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685014886	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685014887	acyl-CoA synthetase; Validated; Region: PRK07798
710685014888	AMP-binding enzyme; Region: AMP-binding; cl15778
710685014889	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685014890	enoyl-CoA hydratase; Provisional; Region: PRK06210
710685014891	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685014892	substrate binding site [chemical binding]; other site
710685014893	oxyanion hole (OAH) forming residues; other site
710685014894	trimer interface [polypeptide binding]; other site
710685014895	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
710685014896	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
710685014897	active site
710685014898	inhibitor site; inhibition site
710685014899	dimer interface [polypeptide binding]; other site
710685014900	catalytic residue [active]
710685014901	enoyl-CoA hydratase; Provisional; Region: PRK08252
710685014902	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685014903	substrate binding site [chemical binding]; other site
710685014904	oxyanion hole (OAH) forming residues; other site
710685014905	trimer interface [polypeptide binding]; other site
710685014906	tetracycline repressor protein TetR; Provisional; Region: PRK13756
710685014907	Helix-turn-helix domains; Region: HTH; cl00088
710685014908	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
710685014909	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
710685014910	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
710685014911	dimer interface [polypeptide binding]; other site
710685014912	active site
710685014913	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685014914	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685014915	substrate binding site [chemical binding]; other site
710685014916	oxyanion hole (OAH) forming residues; other site
710685014917	trimer interface [polypeptide binding]; other site
710685014918	Transcriptional regulators [Transcription]; Region: FadR; COG2186
710685014919	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685014920	DNA-binding site [nucleotide binding]; DNA binding site
710685014921	FCD domain; Region: FCD; cl11656
710685014922	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685014923	CoenzymeA binding site [chemical binding]; other site
710685014924	subunit interaction site [polypeptide binding]; other site
710685014925	PHB binding site; other site
710685014926	enoyl-CoA hydratase; Provisional; Region: PRK06688
710685014927	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685014928	substrate binding site [chemical binding]; other site
710685014929	oxyanion hole (OAH) forming residues; other site
710685014930	trimer interface [polypeptide binding]; other site
710685014931	enoyl-CoA hydratase; Provisional; Region: PRK06494
710685014932	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685014933	substrate binding site [chemical binding]; other site
710685014934	oxyanion hole (OAH) forming residues; other site
710685014935	trimer interface [polypeptide binding]; other site
710685014936	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
710685014937	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685014938	substrate binding site [chemical binding]; other site
710685014939	oxyanion hole (OAH) forming residues; other site
710685014940	trimer interface [polypeptide binding]; other site
710685014941	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
710685014942	AMP-binding enzyme; Region: AMP-binding; cl15778
710685014943	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
710685014944	AMP-binding enzyme; Region: AMP-binding; cl15778
710685014945	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
710685014946	AMP-binding enzyme; Region: AMP-binding; cl15778
710685014947	Transcriptional regulators [Transcription]; Region: GntR; COG1802
710685014948	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685014949	DNA-binding site [nucleotide binding]; DNA binding site
710685014950	FCD domain; Region: FCD; cl11656
710685014951	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685014952	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685014953	active site
710685014954	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
710685014955	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
710685014956	dimer interface [polypeptide binding]; other site
710685014957	active site
710685014958	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685014959	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685014960	NAD(P) binding site [chemical binding]; other site
710685014961	active site
710685014962	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685014963	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685014964	active site
710685014965	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685014966	classical (c) SDRs; Region: SDR_c; cd05233
710685014967	NAD(P) binding site [chemical binding]; other site
710685014968	active site
710685014969	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
710685014970	putative active site [active]
710685014971	putative catalytic site [active]
710685014972	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
710685014973	metal binding site [ion binding]; metal-binding site
710685014974	active site
710685014975	I-site; other site
710685014976	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
710685014977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685014978	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
710685014979	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
710685014980	active site
710685014981	PAS domain S-box; Region: sensory_box; TIGR00229
710685014982	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
710685014983	PAS domain S-box; Region: sensory_box; TIGR00229
710685014984	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
710685014985	PAS domain S-box; Region: sensory_box; TIGR00229
710685014986	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
710685014987	metal binding site [ion binding]; metal-binding site
710685014988	active site
710685014989	I-site; other site
710685014990	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
710685014991	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685014992	active site
710685014993	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
710685014994	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685014995	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
710685014996	active site
710685014997	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
710685014998	EamA-like transporter family; Region: EamA; cl01037
710685014999	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685015000	Helix-turn-helix domains; Region: HTH; cl00088
710685015001	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685015002	Helix-turn-helix domains; Region: HTH; cl00088
710685015003	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685015004	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685015005	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015006	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
710685015007	iron-sulfur cluster [ion binding]; other site
710685015008	[2Fe-2S] cluster binding site [ion binding]; other site
710685015009	Nitronate monooxygenase; Region: NMO; pfam03060
710685015010	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
710685015011	FMN binding site [chemical binding]; other site
710685015012	substrate binding site [chemical binding]; other site
710685015013	putative catalytic residue [active]
710685015014	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
710685015015	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
710685015016	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
710685015017	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
710685015018	RNA/DNA hybrid binding site [nucleotide binding]; other site
710685015019	active site
710685015020	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
710685015021	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
710685015022	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685015023	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
710685015024	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685015025	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685015026	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685015027	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685015028	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685015029	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685015030	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685015031	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
710685015032	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685015033	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685015034	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685015035	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685015036	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685015037	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685015038	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685015039	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685015040	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685015041	active site
710685015042	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
710685015043	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685015044	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685015045	Excalibur calcium-binding domain; Region: Excalibur; cl05460
710685015046	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685015047	Helix-turn-helix domains; Region: HTH; cl00088
710685015048	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
710685015049	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
710685015050	Catalytic domain of Protein Kinases; Region: PKc; cd00180
710685015051	active site
710685015052	ATP binding site [chemical binding]; other site
710685015053	substrate binding site [chemical binding]; other site
710685015054	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
710685015055	substrate binding site [chemical binding]; other site
710685015056	activation loop (A-loop); other site
710685015057	activation loop (A-loop); other site
710685015058	Transport protein; Region: actII; TIGR00833
710685015059	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
710685015060	Helix-turn-helix domains; Region: HTH; cl00088
710685015061	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
710685015062	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685015063	CoenzymeA binding site [chemical binding]; other site
710685015064	subunit interaction site [polypeptide binding]; other site
710685015065	PHB binding site; other site
710685015066	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685015067	Helix-turn-helix domains; Region: HTH; cl00088
710685015068	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685015069	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685015070	Helix-turn-helix domains; Region: HTH; cl00088
710685015071	Helix-turn-helix domains; Region: HTH; cl00088
710685015072	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
710685015073	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685015074	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
710685015075	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
710685015076	active site
710685015077	DNA binding site [nucleotide binding]
710685015078	Int/Topo IB signature motif; other site
710685015079	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685015080	putative substrate translocation pore; other site
710685015081	D-galactonate transporter; Region: 2A0114; TIGR00893
710685015082	phosphoglucomutase; Validated; Region: PRK07564
710685015083	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
710685015084	active site
710685015085	substrate binding site [chemical binding]; other site
710685015086	metal binding site [ion binding]; metal-binding site
710685015087	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
710685015088	catalytic core [active]
710685015089	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
710685015090	Ligand Binding Site [chemical binding]; other site
710685015091	CrcB-like protein; Region: CRCB; cl09114
710685015092	CrcB-like protein; Region: CRCB; cl09114
710685015093	Phosphopantetheine attachment site; Region: PP-binding; cl09936
710685015094	long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851
710685015095	AMP-binding enzyme; Region: AMP-binding; cl15778
710685015096	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
710685015097	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
710685015098	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cd01901
710685015099	active site
710685015100	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685015101	Helix-turn-helix domains; Region: HTH; cl00088
710685015102	Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862
710685015103	putative hydrophobic ligand binding site [chemical binding]; other site
710685015104	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
710685015105	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685015106	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
710685015107	NAD binding site [chemical binding]; other site
710685015108	catalytic residues [active]
710685015109	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
710685015110	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
710685015111	active site
710685015112	dimer interface [polypeptide binding]; other site
710685015113	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
710685015114	active site
710685015115	trimer interface [polypeptide binding]; other site
710685015116	allosteric site; other site
710685015117	active site lid [active]
710685015118	hexamer (dimer of trimers) interface [polypeptide binding]; other site
710685015119	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
710685015120	HPr interaction site; other site
710685015121	glycerol kinase (GK) interaction site [polypeptide binding]; other site
710685015122	active site
710685015123	phosphorylation site [posttranslational modification]
710685015124	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
710685015125	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
710685015126	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
710685015127	active site turn [active]
710685015128	phosphorylation site [posttranslational modification]
710685015129	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
710685015130	AMP-binding enzyme; Region: AMP-binding; cl15778
710685015131	AMP-binding enzyme; Region: AMP-binding; cl15778
710685015132	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
710685015133	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685015134	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
710685015135	FMN binding site [chemical binding]; other site
710685015136	dimer interface [polypeptide binding]; other site
710685015137	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685015138	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015139	enoyl-CoA hydratase; Provisional; Region: PRK08290
710685015140	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685015141	substrate binding site [chemical binding]; other site
710685015142	oxyanion hole (OAH) forming residues; other site
710685015143	trimer interface [polypeptide binding]; other site
710685015144	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
710685015145	CoenzymeA binding site [chemical binding]; other site
710685015146	subunit interaction site [polypeptide binding]; other site
710685015147	PHB binding site; other site
710685015148	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685015149	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685015150	active site
710685015151	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685015152	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685015153	active site
710685015154	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685015155	Helix-turn-helix domains; Region: HTH; cl00088
710685015156	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685015157	enoyl-CoA hydratase; Provisional; Region: PRK06494
710685015158	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685015159	substrate binding site [chemical binding]; other site
710685015160	oxyanion hole (OAH) forming residues; other site
710685015161	trimer interface [polypeptide binding]; other site
710685015162	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
710685015163	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015164	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
710685015165	substrate binding pocket [chemical binding]; other site
710685015166	active site
710685015167	iron coordination sites [ion binding]; other site
710685015168	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
710685015169	thiolase; Provisional; Region: PRK06158
710685015170	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685015171	active site
710685015172	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685015173	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685015174	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685015175	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
710685015176	AMP-binding enzyme; Region: AMP-binding; cl15778
710685015177	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
710685015178	homodimer interface [polypeptide binding]; other site
710685015179	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685015180	NAD binding site [chemical binding]; other site
710685015181	active site
710685015182	enoyl-CoA hydratase; Provisional; Region: PRK06688
710685015183	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685015184	substrate binding site [chemical binding]; other site
710685015185	oxyanion hole (OAH) forming residues; other site
710685015186	trimer interface [polypeptide binding]; other site
710685015187	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685015188	active site 1 [active]
710685015189	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
710685015190	active site 2 [active]
710685015191	active site 1 [active]
710685015192	enoyl-CoA hydratase; Provisional; Region: PRK06688
710685015193	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685015194	substrate binding site [chemical binding]; other site
710685015195	oxyanion hole (OAH) forming residues; other site
710685015196	trimer interface [polypeptide binding]; other site
710685015197	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685015198	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
710685015199	active site
710685015200	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685015201	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685015202	substrate binding site [chemical binding]; other site
710685015203	oxyanion hole (OAH) forming residues; other site
710685015204	trimer interface [polypeptide binding]; other site
710685015205	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
710685015206	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
710685015207	substrate binding site [chemical binding]; other site
710685015208	oxyanion hole (OAH) forming residues; other site
710685015209	trimer interface [polypeptide binding]; other site
710685015210	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
710685015211	AMP-binding enzyme; Region: AMP-binding; cl15778
710685015212	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015213	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
710685015214	NAD(P) binding site [chemical binding]; other site
710685015215	active site
710685015216	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015217	active site
710685015218	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685015219	classical (c) SDRs; Region: SDR_c; cd05233
710685015220	NAD(P) binding site [chemical binding]; other site
710685015221	active site
710685015222	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685015223	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
710685015224	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685015225	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685015226	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015227	Protein of unknown function (DUF1749); Region: DUF1749; pfam08538
710685015228	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685015229	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015230	short chain dehydrogenase; Provisional; Region: PRK07063
710685015231	NAD(P) binding site [chemical binding]; other site
710685015232	active site
710685015233	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685015234	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
710685015235	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
710685015236	putative NAD(P) binding site [chemical binding]; other site
710685015237	catalytic Zn binding site [ion binding]; other site
710685015238	Transcriptional regulator [Transcription]; Region: IclR; COG1414
710685015239	Helix-turn-helix domains; Region: HTH; cl00088
710685015240	Domain of unknown function (DUF222); Region: DUF222; pfam02720
710685015241	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
710685015242	active site
710685015243	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
710685015244	AMP-binding enzyme; Region: AMP-binding; cl15778
710685015245	AMP-binding enzyme; Region: AMP-binding; cl15778
710685015246	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685015247	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685015248	active site
710685015249	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685015250	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685015251	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685015252	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685015253	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685015254	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
710685015255	active site
710685015256	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
710685015257	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685015258	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685015259	Isochorismatase family; Region: Isochorismatase; pfam00857
710685015260	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
710685015261	catalytic triad [active]
710685015262	conserved cis-peptide bond; other site
710685015263	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685015264	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
710685015265	putative active site [active]
710685015266	putative catalytic site [active]
710685015267	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685015268	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685015269	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685015270	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685015271	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685015272	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
710685015273	NAD binding site [chemical binding]; other site
710685015274	catalytic residues [active]
710685015275	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685015276	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685015277	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685015278	active site
710685015279	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
710685015280	active site
710685015281	catalytic site [active]
710685015282	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
710685015283	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685015284	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685015285	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685015286	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685015287	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
710685015288	active site
710685015289	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
710685015290	putative active site [active]
710685015291	putative catalytic site [active]
710685015292	lipid-transfer protein; Provisional; Region: PRK07855
710685015293	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685015294	active site
710685015295	Helix-turn-helix domains; Region: HTH; cl00088
710685015296	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
710685015297	metal binding site [ion binding]; metal-binding site
710685015298	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685015299	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
710685015300	CoA-transferase family III; Region: CoA_transf_3; pfam02515
710685015301	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685015302	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
710685015303	AMP-binding enzyme; Region: AMP-binding; cl15778
710685015304	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
710685015305	short chain dehydrogenase; Provisional; Region: PRK07814
710685015306	classical (c) SDRs; Region: SDR_c; cd05233
710685015307	NAD(P) binding site [chemical binding]; other site
710685015308	active site
710685015309	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685015310	classical (c) SDRs; Region: SDR_c; cd05233
710685015311	NAD(P) binding site [chemical binding]; other site
710685015312	active site
710685015313	Transcriptional regulators [Transcription]; Region: GntR; COG1802
710685015314	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
710685015315	DNA-binding site [nucleotide binding]; DNA binding site
710685015316	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015317	NAD(P) binding site [chemical binding]; other site
710685015318	active site
710685015319	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685015320	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685015321	classical (c) SDRs; Region: SDR_c; cd05233
710685015322	NAD(P) binding site [chemical binding]; other site
710685015323	active site
710685015324	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
710685015325	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
710685015326	classical (c) SDRs; Region: SDR_c; cd05233
710685015327	NAD(P) binding site [chemical binding]; other site
710685015328	active site
710685015329	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685015330	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015331	NAD(P) binding site [chemical binding]; other site
710685015332	active site
710685015333	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015334	NAD(P) binding site [chemical binding]; other site
710685015335	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
710685015336	active site
710685015337	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685015338	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015339	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015340	NAD(P) binding site [chemical binding]; other site
710685015341	active site
710685015342	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685015343	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
710685015344	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685015345	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015346	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
710685015347	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
710685015348	ligand binding site [chemical binding]; other site
710685015349	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
710685015350	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685015351	Helix-turn-helix domains; Region: HTH; cl00088
710685015352	classical (c) SDRs; Region: SDR_c; cd05233
710685015353	NAD(P) binding site [chemical binding]; other site
710685015354	active site
710685015355	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
710685015356	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
710685015357	NAD binding site [chemical binding]; other site
710685015358	catalytic residues [active]
710685015359	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
710685015360	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
710685015361	NAD binding site [chemical binding]; other site
710685015362	catalytic Zn binding site [ion binding]; other site
710685015363	substrate binding site [chemical binding]; other site
710685015364	structural Zn binding site [ion binding]; other site
710685015365	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
710685015366	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685015367	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685015368	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
710685015369	putative acyl-acceptor binding pocket; other site
710685015370	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
710685015371	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
710685015372	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
710685015373	short chain dehydrogenase; Provisional; Region: PRK07856
710685015374	classical (c) SDRs; Region: SDR_c; cd05233
710685015375	NAD(P) binding site [chemical binding]; other site
710685015376	active site
710685015377	3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837
710685015378	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685015379	classical (c) SDRs; Region: SDR_c; cd05233
710685015380	NAD(P) binding site [chemical binding]; other site
710685015381	active site
710685015382	amino acid transporter; Region: 2A0306; TIGR00909
710685015383	Spore germination protein; Region: Spore_permease; cl15802
710685015384	Transcriptional regulator [Transcription]; Region: IclR; COG1414
710685015385	Helix-turn-helix domains; Region: HTH; cl00088
710685015386	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
710685015387	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
710685015388	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685015389	classical (c) SDRs; Region: SDR_c; cd05233
710685015390	NAD(P) binding site [chemical binding]; other site
710685015391	active site
710685015392	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685015393	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
710685015394	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
710685015395	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
710685015396	active site
710685015397	diiron metal binding site [ion binding]; other site
710685015398	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
710685015399	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685015400	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685015401	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685015402	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685015403	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685015404	lipid-transfer protein; Provisional; Region: PRK07855
710685015405	active site
710685015406	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
710685015407	NADH(P)-binding; Region: NAD_binding_10; pfam13460
710685015408	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015409	NAD(P) binding site [chemical binding]; other site
710685015410	active site
710685015411	Predicted amidohydrolase [General function prediction only]; Region: COG0388
710685015412	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
710685015413	putative active site [active]
710685015414	catalytic triad [active]
710685015415	putative dimer interface [polypeptide binding]; other site
710685015416	Domain of unknown function DUF302; Region: DUF302; cl01364
710685015417	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685015418	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
710685015419	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
710685015420	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
710685015421	active site
710685015422	iron coordination sites [ion binding]; other site
710685015423	substrate binding pocket [chemical binding]; other site
710685015424	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685015425	[2Fe-2S] cluster binding site [ion binding]; other site
710685015426	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
710685015427	alpha subunit interface [polypeptide binding]; other site
710685015428	active site
710685015429	substrate binding site [chemical binding]; other site
710685015430	Fe binding site [ion binding]; other site
710685015431	Transcriptional regulator [Transcription]; Region: LysR; COG0583
710685015432	Helix-turn-helix domains; Region: HTH; cl00088
710685015433	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
710685015434	putative effector binding pocket; other site
710685015435	dimerization interface [polypeptide binding]; other site
710685015436	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685015437	Domain of unknown function (DUF385); Region: DUF385; cl04387
710685015438	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
710685015439	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685015440	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
710685015441	putative dimer interface [polypeptide binding]; other site
710685015442	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
710685015443	ligand binding site [chemical binding]; other site
710685015444	Zn binding site [ion binding]; other site
710685015445	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
710685015446	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
710685015447	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
710685015448	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
710685015449	DNA binding residues [nucleotide binding]
710685015450	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
710685015451	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
710685015452	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
710685015453	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685015454	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685015455	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685015456	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
710685015457	Transport protein; Region: actII; TIGR00833
710685015458	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
710685015459	anti sigma factor interaction site; other site
710685015460	regulatory phosphorylation site [posttranslational modification]; other site
710685015461	GAF domain; Region: GAF; cl15785
710685015462	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
710685015463	dimer interface [polypeptide binding]; other site
710685015464	phosphorylation site [posttranslational modification]
710685015465	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
710685015466	ATP binding site [chemical binding]; other site
710685015467	Mg2+ binding site [ion binding]; other site
710685015468	G-X-G motif; other site
710685015469	Response regulator receiver domain; Region: Response_reg; pfam00072
710685015470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
710685015471	active site
710685015472	phosphorylation site [posttranslational modification]
710685015473	intermolecular recognition site; other site
710685015474	dimerization interface [polypeptide binding]; other site
710685015475	PAS domain S-box; Region: sensory_box; TIGR00229
710685015476	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
710685015477	putative active site [active]
710685015478	heme pocket [chemical binding]; other site
710685015479	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
710685015480	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
710685015481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
710685015482	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
710685015483	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
710685015484	anti sigma factor interaction site; other site
710685015485	regulatory phosphorylation site [posttranslational modification]; other site
710685015486	PAS fold; Region: PAS_3; pfam08447
710685015487	ANTAR domain; Region: ANTAR; cl04297
710685015488	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
710685015489	PhoU domain; Region: PhoU; pfam01895
710685015490	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331
710685015491	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
710685015492	DUF35 OB-fold domain; Region: DUF35; pfam01796
710685015493	acetyl-CoA acetyltransferase; Provisional; Region: PRK08142
710685015494	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
710685015495	active site
710685015496	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685015497	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
710685015498	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685015499	active site
710685015500	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
710685015501	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
710685015502	active site
710685015503	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
710685015504	Helix-turn-helix domains; Region: HTH; cl00088
710685015505	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
710685015506	OsmC-like protein; Region: OsmC; cl00767
710685015507	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
710685015508	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
710685015509	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
710685015510	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
710685015511	DNA binding residues [nucleotide binding]
710685015512	putative dimer interface [polypeptide binding]; other site
710685015513	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
710685015514	PAS fold; Region: PAS_3; pfam08447
710685015515	putative active site [active]
710685015516	heme pocket [chemical binding]; other site
710685015517	ANTAR domain; Region: ANTAR; cl04297
710685015518	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
710685015519	classical (c) SDRs; Region: SDR_c; cd05233
710685015520	NAD(P) binding site [chemical binding]; other site
710685015521	active site
710685015522	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
710685015523	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
710685015524	putative acyl-acceptor binding pocket; other site
710685015525	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
710685015526	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685015527	phosphopeptide binding site; other site
710685015528	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
710685015529	phosphopeptide binding site; other site
710685015530	ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213
710685015531	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
710685015532	Walker A/P-loop; other site
710685015533	ATP binding site [chemical binding]; other site
710685015534	Q-loop/lid; other site
710685015535	ABC transporter signature motif; other site
710685015536	Walker B; other site
710685015537	D-loop; other site
710685015538	H-loop/switch region; other site
710685015539	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
710685015540	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
710685015541	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
710685015542	NAD(P) binding site [chemical binding]; other site
710685015543	active site
710685015544	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
710685015545	active site
710685015546	metal binding site [ion binding]; metal-binding site
710685015547	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
710685015548	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
710685015549	active site
710685015550	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
710685015551	catalytic triad [active]
710685015552	dimer interface [polypeptide binding]; other site
710685015553	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
710685015554	classical (c) SDRs; Region: SDR_c; cd05233
710685015555	NAD(P) binding site [chemical binding]; other site
710685015556	active site
710685015557	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685015558	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
710685015559	active site
710685015560	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
710685015561	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
710685015562	[2Fe-2S] cluster binding site [ion binding]; other site
710685015563	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
710685015564	hydrophobic ligand binding site; other site
710685015565	tetracycline repressor protein TetR; Provisional; Region: PRK13756
710685015566	Helix-turn-helix domains; Region: HTH; cl00088
710685015567	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
710685015568	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
710685015569	Major Facilitator Superfamily; Region: MFS_1; pfam07690
710685015570	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
710685015571	putative substrate translocation pore; other site
710685015572	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
710685015573	nucleoside/Zn binding site; other site
710685015574	dimer interface [polypeptide binding]; other site
710685015575	catalytic motif [active]
710685015576	Transport protein; Region: actII; TIGR00833
710685015577	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
710685015578	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
710685015579	Helix-turn-helix domains; Region: HTH; cl00088
710685015580	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
710685015581	active site