-- dump date 20111121_013400 -- class Genbank::misc_feature -- table misc_feature_note -- id note 336982000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 336982000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982000003 Walker A motif; other site 336982000004 ATP binding site [chemical binding]; other site 336982000005 Walker B motif; other site 336982000006 arginine finger; other site 336982000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 336982000008 DnaA box-binding interface [nucleotide binding]; other site 336982000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 336982000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 336982000011 putative DNA binding surface [nucleotide binding]; other site 336982000012 dimer interface [polypeptide binding]; other site 336982000013 beta-clamp/clamp loader binding surface; other site 336982000014 beta-clamp/translesion DNA polymerase binding surface; other site 336982000015 recombination protein F; Reviewed; Region: recF; PRK00064 336982000016 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 336982000017 Walker A/P-loop; other site 336982000018 ATP binding site [chemical binding]; other site 336982000019 Q-loop/lid; other site 336982000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982000021 ABC transporter signature motif; other site 336982000022 Walker B; other site 336982000023 D-loop; other site 336982000024 H-loop/switch region; other site 336982000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 336982000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 336982000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 336982000028 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 336982000029 anchoring element; other site 336982000030 dimer interface [polypeptide binding]; other site 336982000031 ATP binding site [chemical binding]; other site 336982000032 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 336982000033 active site 336982000034 putative metal-binding site [ion binding]; other site 336982000035 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 336982000036 DNA gyrase subunit A; Validated; Region: PRK05560 336982000037 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 336982000038 CAP-like domain; other site 336982000039 Active site [active] 336982000040 primary dimer interface [polypeptide binding]; other site 336982000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 336982000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 336982000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 336982000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 336982000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 336982000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 336982000047 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 336982000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 336982000049 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 336982000050 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 336982000051 active site 336982000052 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 336982000053 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 336982000054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 336982000055 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 336982000056 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 336982000057 Glutamine amidotransferase class-I; Region: GATase; pfam00117 336982000058 glutamine binding [chemical binding]; other site 336982000059 catalytic triad [active] 336982000060 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982000061 active site 336982000062 ATP binding site [chemical binding]; other site 336982000063 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982000064 substrate binding site [chemical binding]; other site 336982000065 activation loop (A-loop); other site 336982000066 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 336982000067 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 336982000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 336982000069 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 336982000070 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982000071 active site 336982000072 ATP binding site [chemical binding]; other site 336982000073 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982000074 substrate binding site [chemical binding]; other site 336982000075 activation loop (A-loop); other site 336982000076 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 336982000077 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 336982000078 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 336982000079 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 336982000080 Active site [active] 336982000081 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 336982000082 phosphopeptide binding site; other site 336982000083 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 336982000084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 336982000085 phosphopeptide binding site; other site 336982000086 Nitronate monooxygenase; Region: NMO; pfam03060 336982000087 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 336982000088 FMN binding site [chemical binding]; other site 336982000089 substrate binding site [chemical binding]; other site 336982000090 putative catalytic residue [active] 336982000091 Transcription factor WhiB; Region: Whib; pfam02467 336982000092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982000093 non-specific DNA binding site [nucleotide binding]; other site 336982000094 salt bridge; other site 336982000095 sequence-specific DNA binding site [nucleotide binding]; other site 336982000096 NlpC/P60 family; Region: NLPC_P60; cl11438 336982000097 Biofilm regulator BssS; Region: BssS; pfam10774 336982000098 Biofilm regulator BssS; Region: BssS; pfam10774 336982000099 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 336982000100 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 336982000101 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 336982000102 FemAB family; Region: FemAB; cl11444 336982000103 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 336982000104 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982000105 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982000106 catalytic residue [active] 336982000107 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982000108 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982000109 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 336982000110 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982000111 TIGR03084 family protein; Region: TIGR03084 336982000112 DinB superfamily; Region: DinB_2; cl00986 336982000113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 336982000114 H+ Antiporter protein; Region: 2A0121; TIGR00900 336982000115 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 336982000116 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 336982000117 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 336982000118 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982000119 active site 336982000120 HIGH motif; other site 336982000121 nucleotide binding site [chemical binding]; other site 336982000122 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982000123 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982000124 active site 336982000125 KMSKS motif; other site 336982000126 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 336982000127 tRNA binding surface [nucleotide binding]; other site 336982000128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982000129 Transcriptional regulators [Transcription]; Region: GntR; COG1802 336982000130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982000131 DNA-binding site [nucleotide binding]; DNA binding site 336982000132 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 336982000133 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982000134 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 336982000135 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 336982000136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982000137 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 336982000138 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 336982000139 Transglycosylase; Region: Transgly; cl07896 336982000140 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 336982000141 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 336982000142 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 336982000143 conserved cys residue [active] 336982000144 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 336982000145 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 336982000146 dimer interface [polypeptide binding]; other site 336982000147 ssDNA binding site [nucleotide binding]; other site 336982000148 tetramer (dimer of dimers) interface [polypeptide binding]; other site 336982000149 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 336982000150 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 336982000151 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 336982000152 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 336982000153 replicative DNA helicase; Validated; Region: PRK07773 336982000154 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 336982000155 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 336982000156 Walker A motif; other site 336982000157 ATP binding site [chemical binding]; other site 336982000158 Walker B motif; other site 336982000159 DNA binding loops [nucleotide binding] 336982000160 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 336982000161 thioester formation/cholesterol transfer; other site 336982000162 protein-splicing catalytic site; other site 336982000163 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 336982000164 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982000165 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 336982000166 ADP-ribose binding site [chemical binding]; other site 336982000167 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 336982000168 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 336982000169 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982000170 FAD binding domain; Region: FAD_binding_4; pfam01565 336982000171 Berberine and berberine like; Region: BBE; pfam08031 336982000172 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 336982000173 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 336982000174 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 336982000175 homotetrameric interface [polypeptide binding]; other site 336982000176 putative active site [active] 336982000177 metal binding site [ion binding]; metal-binding site 336982000178 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 336982000179 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 336982000180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000182 short chain dehydrogenase; Provisional; Region: PRK06197 336982000183 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 336982000184 putative NAD(P) binding site [chemical binding]; other site 336982000185 active site 336982000186 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 336982000187 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 336982000188 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 336982000189 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 336982000190 dimer interface [polypeptide binding]; other site 336982000191 glycine-pyridoxal phosphate binding site [chemical binding]; other site 336982000192 active site 336982000193 folate binding site [chemical binding]; other site 336982000194 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 336982000195 putative NTP binding site [chemical binding]; other site 336982000196 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 336982000197 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 336982000198 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 336982000199 Walker A/P-loop; other site 336982000200 ATP binding site [chemical binding]; other site 336982000201 Q-loop/lid; other site 336982000202 ABC transporter signature motif; other site 336982000203 Walker B; other site 336982000204 D-loop; other site 336982000205 H-loop/switch region; other site 336982000206 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982000207 ligand binding site [chemical binding]; other site 336982000208 flexible hinge region; other site 336982000209 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 336982000210 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 336982000211 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 336982000212 active site 336982000213 aspartate aminotransferase; Provisional; Region: PRK08361 336982000214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982000215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982000216 homodimer interface [polypeptide binding]; other site 336982000217 catalytic residue [active] 336982000218 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982000219 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000221 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 336982000222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982000223 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 336982000224 hydrogenase 4 subunit B; Validated; Region: PRK06521 336982000225 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 336982000226 NADH dehydrogenase; Region: NADHdh; cl00469 336982000227 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl12087 336982000228 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 336982000229 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 336982000230 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 336982000231 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 336982000232 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 336982000233 putative hydrophobic ligand binding site [chemical binding]; other site 336982000234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982000235 S-adenosylmethionine binding site [chemical binding]; other site 336982000236 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 336982000237 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 336982000238 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 336982000239 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 336982000240 metal-binding site [ion binding] 336982000241 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982000242 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982000243 Predicted integral membrane protein [Function unknown]; Region: COG5660 336982000244 Domain of unknown function DUF222; Region: DUF222; pfam02720 336982000245 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982000246 active site 336982000247 PPE family; Region: PPE; pfam00823 336982000248 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 336982000249 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 336982000250 FcoT-like thioesterase domain; Region: FcoT; pfam10862 336982000251 acyl-CoA synthetase; Validated; Region: PRK05857 336982000252 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982000253 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982000254 AMP-binding enzyme; Region: AMP-binding; pfam00501 336982000255 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982000256 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982000257 Condensation domain; Region: Condensation; cl09290 336982000258 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 336982000259 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982000260 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982000261 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 336982000262 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 336982000263 putative NAD(P) binding site [chemical binding]; other site 336982000264 active site 336982000265 putative substrate binding site [chemical binding]; other site 336982000266 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 336982000267 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 336982000268 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 336982000269 metal-binding site [ion binding] 336982000270 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982000271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982000272 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 336982000273 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982000274 ligand binding site [chemical binding]; other site 336982000275 flexible hinge region; other site 336982000276 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 336982000277 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 336982000278 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 336982000279 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982000280 HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 336982000281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982000282 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 336982000283 PE family; Region: PE; pfam00934 336982000284 Rhomboid family; Region: Rhomboid; cl11446 336982000285 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 336982000286 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 336982000287 active site 336982000288 catalytic triad [active] 336982000289 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 336982000290 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 336982000291 NADP-binding site; other site 336982000292 homotetramer interface [polypeptide binding]; other site 336982000293 substrate binding site [chemical binding]; other site 336982000294 homodimer interface [polypeptide binding]; other site 336982000295 active site 336982000296 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 336982000297 dimer interface [polypeptide binding]; other site 336982000298 active site 336982000299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 336982000300 active site 336982000301 motif I; other site 336982000302 motif II; other site 336982000303 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 336982000304 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 336982000305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 336982000306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982000307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 336982000308 dimerization interface [polypeptide binding]; other site 336982000309 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 336982000310 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 336982000311 PYR/PP interface [polypeptide binding]; other site 336982000312 dimer interface [polypeptide binding]; other site 336982000313 TPP binding site [chemical binding]; other site 336982000314 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 336982000315 TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules...; Region: TPP_BZL_OCoD_HPCL; cd02004 336982000316 TPP-binding site; other site 336982000317 dimer interface [polypeptide binding]; other site 336982000318 acyl-CoA synthetase; Validated; Region: PRK05852 336982000319 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982000320 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 336982000321 elongation factor G; Reviewed; Region: PRK12740 336982000322 G1 box; other site 336982000323 putative GEF interaction site [polypeptide binding]; other site 336982000324 GTP/Mg2+ binding site [chemical binding]; other site 336982000325 Switch I region; other site 336982000326 G2 box; other site 336982000327 G3 box; other site 336982000328 Switch II region; other site 336982000329 G4 box; other site 336982000330 G5 box; other site 336982000331 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 336982000332 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 336982000333 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 336982000334 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 336982000335 PE family; Region: PE; pfam00934 336982000336 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 336982000337 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 336982000338 trehalose synthase; Region: treS_nterm; TIGR02456 336982000339 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 336982000340 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 336982000341 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 336982000342 Predicted esterase [General function prediction only]; Region: COG0627 336982000343 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 336982000344 putative active site [active] 336982000345 putative catalytic site [active] 336982000346 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982000347 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982000348 active site 336982000349 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982000350 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 336982000351 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982000352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 336982000353 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982000354 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982000355 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982000356 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000357 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000358 Cytochrome P450; Region: p450; cl12078 336982000359 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 336982000360 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982000361 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 336982000362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982000363 NAD(P) binding site [chemical binding]; other site 336982000364 active site 336982000365 Domain of unknown function (DUF427); Region: DUF427; cl00998 336982000366 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982000367 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 336982000368 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 336982000369 minor groove reading motif; other site 336982000370 helix-hairpin-helix signature motif; other site 336982000371 active site 336982000372 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 336982000373 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 336982000374 Cl- selectivity filter; other site 336982000375 Cl- binding residues [ion binding]; other site 336982000376 pore gating glutamate residue; other site 336982000377 dimer interface [polypeptide binding]; other site 336982000378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000380 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982000381 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982000382 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982000383 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 336982000384 NAD(P) binding site [chemical binding]; other site 336982000385 catalytic residues [active] 336982000386 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 336982000387 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 336982000388 NAD binding site [chemical binding]; other site 336982000389 homodimer interface [polypeptide binding]; other site 336982000390 active site 336982000391 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 336982000392 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 336982000393 NAD(P) binding site [chemical binding]; other site 336982000394 PE family; Region: PE; pfam00934 336982000395 PE-PPE domain; Region: PE-PPE; pfam08237 336982000396 PE-PPE domain; Region: PE-PPE; pfam08237 336982000397 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 336982000398 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 336982000399 FAD binding site [chemical binding]; other site 336982000400 substrate binding site [chemical binding]; other site 336982000401 catalytic base [active] 336982000402 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 336982000403 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 336982000404 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 336982000405 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 336982000406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000408 PE family; Region: PE; pfam00934 336982000409 PE-PPE domain; Region: PE-PPE; pfam08237 336982000410 PE family; Region: PE; pfam00934 336982000411 PE-PPE domain; Region: PE-PPE; pfam08237 336982000412 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982000413 FAD binding domain; Region: FAD_binding_4; pfam01565 336982000414 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 336982000415 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 336982000416 NAD(P) binding site [chemical binding]; other site 336982000417 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 336982000418 active site 336982000419 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 336982000420 putative hydrophobic ligand binding site [chemical binding]; other site 336982000421 Predicted transcriptional regulators [Transcription]; Region: COG1725 336982000422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982000423 DNA-binding site [nucleotide binding]; DNA binding site 336982000424 FCD domain; Region: FCD; cl11656 336982000425 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 336982000426 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982000427 Domain of unknown function DUF140; Region: DUF140; cl00510 336982000428 Domain of unknown function DUF140; Region: DUF140; cl00510 336982000429 mce related protein; Region: MCE; cl03606 336982000430 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 336982000431 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982000432 mce related protein; Region: MCE; cl03606 336982000433 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982000434 mce related protein; Region: MCE; cl03606 336982000435 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982000436 mce related protein; Region: MCE; cl03606 336982000437 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982000438 mce related protein; Region: MCE; cl03606 336982000439 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982000440 mce related protein; Region: MCE; cl03606 336982000441 large tegument protein UL36; Provisional; Region: PHA03247 336982000442 RDD family; Region: RDD; cl00746 336982000443 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 336982000444 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 336982000445 ABC-2 type transporter; Region: ABC2_membrane; cl11417 336982000446 Pirin-related protein [General function prediction only]; Region: COG1741 336982000447 Cupin domain; Region: Cupin_2; cl09118 336982000448 RNA polymerase factor sigma-70; Validated; Region: PRK08241 336982000449 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982000450 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 336982000451 DNA binding residues [nucleotide binding] 336982000452 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982000453 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 336982000454 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982000455 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 336982000456 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 336982000457 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 336982000458 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 336982000459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982000460 S-adenosylmethionine binding site [chemical binding]; other site 336982000461 SPW repeat; Region: SPW; pfam03779 336982000462 SPW repeat; Region: SPW; pfam03779 336982000463 Dehydratase family; Region: ILVD_EDD; cl00340 336982000464 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 336982000465 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 336982000466 putative homotetramer interface [polypeptide binding]; other site 336982000467 putative homodimer interface [polypeptide binding]; other site 336982000468 putative allosteric switch controlling residues; other site 336982000469 putative metal binding site [ion binding]; other site 336982000470 putative homodimer-homodimer interface [polypeptide binding]; other site 336982000471 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 336982000472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982000473 putative substrate translocation pore; other site 336982000474 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 336982000475 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 336982000476 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 336982000477 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982000478 Walker A/P-loop; other site 336982000479 ATP binding site [chemical binding]; other site 336982000480 Q-loop/lid; other site 336982000481 ABC transporter signature motif; other site 336982000482 Walker B; other site 336982000483 D-loop; other site 336982000484 H-loop/switch region; other site 336982000485 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 336982000486 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982000487 Walker A/P-loop; other site 336982000488 ATP binding site [chemical binding]; other site 336982000489 Q-loop/lid; other site 336982000490 ABC transporter signature motif; other site 336982000491 Walker B; other site 336982000492 D-loop; other site 336982000493 H-loop/switch region; other site 336982000494 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 336982000495 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 336982000496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000497 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 336982000498 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 336982000499 putative [Fe4-S4] binding site [ion binding]; other site 336982000500 putative molybdopterin cofactor binding site [chemical binding]; other site 336982000501 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 336982000502 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 336982000503 putative molybdopterin cofactor binding site; other site 336982000504 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 336982000505 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 336982000506 active site 336982000507 Zn binding site [ion binding]; other site 336982000508 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982000509 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 336982000510 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 336982000511 Domain of unknown function DUF20; Region: UPF0118; cl00465 336982000512 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982000513 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 336982000514 putative metal binding site [ion binding]; other site 336982000515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982000516 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 336982000517 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 336982000518 active site 336982000519 substrate-binding site [chemical binding]; other site 336982000520 metal-binding site [ion binding] 336982000521 GTP binding site [chemical binding]; other site 336982000522 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 336982000523 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 336982000524 active site 336982000525 (T/H)XGH motif; other site 336982000526 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; cl01238 336982000527 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 336982000528 Radical SAM; Region: Elp3; smart00729 336982000529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 336982000530 FeS/SAM binding site; other site 336982000531 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 336982000532 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982000533 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982000534 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982000535 active site 336982000536 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 336982000537 putative active site [active] 336982000538 putative catalytic site [active] 336982000539 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 336982000540 active site 2 [active] 336982000541 active site 1 [active] 336982000542 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982000543 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982000544 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 336982000545 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 336982000546 Moco binding site; other site 336982000547 metal coordination site [ion binding]; other site 336982000548 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982000549 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982000550 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982000551 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982000552 Condensation domain; Region: Condensation; cl09290 336982000553 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 336982000554 enoyl-CoA hydratase; Provisional; Region: PRK08252 336982000555 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982000556 substrate binding site [chemical binding]; other site 336982000557 oxyanion hole (OAH) forming residues; other site 336982000558 trimer interface [polypeptide binding]; other site 336982000559 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 336982000560 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982000561 NAD binding site [chemical binding]; other site 336982000562 catalytic residues [active] 336982000563 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 336982000564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982000565 S-adenosylmethionine binding site [chemical binding]; other site 336982000566 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 336982000567 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 336982000568 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 336982000569 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 336982000570 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982000571 putative active site [active] 336982000572 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 336982000573 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active...; Region: PTE; cd00530 336982000574 active site 336982000575 substrate binding pocket [chemical binding]; other site 336982000576 homodimer interaction site [polypeptide binding]; other site 336982000577 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982000578 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 336982000579 active site 336982000580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000582 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 336982000583 active site 336982000584 diiron metal binding site [ion binding]; other site 336982000585 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 336982000586 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982000587 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 336982000588 NAD(P) binding site [chemical binding]; other site 336982000589 catalytic residues [active] 336982000590 Protein of unknown function (DUF1222); Region: DUF1222; pfam06762 336982000591 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 336982000592 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 336982000593 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 336982000594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000596 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982000597 enoyl-CoA hydratase; Region: PLN02864 336982000598 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 336982000599 active site 2 [active] 336982000600 active site 1 [active] 336982000601 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 336982000602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982000603 NAD(P) binding site [chemical binding]; other site 336982000604 active site 336982000605 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 336982000606 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 336982000607 dimer interface [polypeptide binding]; other site 336982000608 active site 336982000609 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 336982000610 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 336982000611 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 336982000612 FAD binding site [chemical binding]; other site 336982000613 substrate binding site [chemical binding]; other site 336982000614 catalytic residues [active] 336982000615 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 336982000616 Flavin Reductases; Region: FlaRed; cl00801 336982000617 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 336982000618 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982000619 catalytic loop [active] 336982000620 iron binding site [ion binding]; other site 336982000621 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 336982000622 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982000623 domain; Region: Succ_DH_flav_C; pfam02910 336982000624 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 336982000625 putative dimer interface [polypeptide binding]; other site 336982000626 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 336982000627 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982000628 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 336982000629 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 336982000630 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 336982000631 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 336982000632 homotrimer interface [polypeptide binding]; other site 336982000633 Walker A motif; other site 336982000634 GTP binding site [chemical binding]; other site 336982000635 Walker B motif; other site 336982000636 cobyric acid synthase; Provisional; Region: PRK00784 336982000637 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 336982000638 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 336982000639 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 336982000640 catalytic triad [active] 336982000641 PPE family; Region: PPE; pfam00823 336982000642 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 336982000643 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 336982000644 putative active site [active] 336982000645 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_C; cd03414 336982000646 putative active site [active] 336982000647 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 336982000648 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 336982000649 active site 336982000650 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 336982000651 DNA binding site [nucleotide binding] 336982000652 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 336982000653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 336982000654 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 336982000655 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 336982000656 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 336982000657 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 336982000658 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 336982000659 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 336982000660 intersubunit interface [polypeptide binding]; other site 336982000661 5-oxoprolinase; Region: PLN02666 336982000662 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 336982000663 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 336982000664 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 336982000665 Phd_YefM; Region: PhdYeFM; cl09153 336982000666 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 336982000667 nucleotide binding site [chemical binding]; other site 336982000668 acyl-CoA synthetase; Validated; Region: PRK07788 336982000669 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982000670 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982000671 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982000672 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 336982000673 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982000674 FAD binding site [chemical binding]; other site 336982000675 substrate binding site [chemical binding]; other site 336982000676 catalytic base [active] 336982000677 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 336982000678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000680 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 336982000681 Zn binding site [ion binding]; other site 336982000682 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 336982000683 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982000684 PE family; Region: PE; pfam00934 336982000685 PE family; Region: PE; pfam00934 336982000686 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000687 PPE family; Region: PPE; pfam00823 336982000688 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000689 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982000690 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 336982000691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982000692 Walker A motif; other site 336982000693 ATP binding site [chemical binding]; other site 336982000694 Walker B motif; other site 336982000695 arginine finger; other site 336982000696 Protein of unknown function (DUF690); Region: DUF690; cl04939 336982000697 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 336982000698 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982000699 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 336982000700 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982000701 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982000702 PPE family; Region: PPE; pfam00823 336982000703 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982000704 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 336982000705 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 336982000706 active site 336982000707 catalytic residues [active] 336982000708 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 336982000709 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982000710 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982000711 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 336982000712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982000713 S-adenosylmethionine binding site [chemical binding]; other site 336982000714 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 336982000715 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 336982000716 Sulfatase; Region: Sulfatase; cl10460 336982000717 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982000718 putative active site [active] 336982000719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982000720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000721 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 336982000722 short chain dehydrogenase; Provisional; Region: PRK06197 336982000723 putative NAD(P) binding site [chemical binding]; other site 336982000724 active site 336982000725 PPE family; Region: PPE; pfam00823 336982000726 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000727 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000728 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982000729 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982000730 Sec24-related protein; Provisional; Region: PTZ00395 336982000731 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(; Region: BluB; cd02145 336982000732 putative FMN binding site [chemical binding]; other site 336982000733 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 336982000734 active site 336982000735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 336982000736 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 336982000737 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 336982000738 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 336982000739 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 336982000740 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 336982000741 active site 336982000742 catalytic residues [active] 336982000743 Muconolactone delta-isomerase; Region: MIase; cl01992 336982000744 Muconolactone delta-isomerase; Region: MIase; cl01992 336982000745 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 336982000746 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 336982000747 putative active site [active] 336982000748 catalytic site [active] 336982000749 putative metal binding site [ion binding]; other site 336982000750 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 336982000751 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 336982000752 putative substrate binding pocket [chemical binding]; other site 336982000753 AC domain interface; other site 336982000754 catalytic triad [active] 336982000755 AB domain interface; other site 336982000756 interchain disulfide; other site 336982000757 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 336982000758 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 336982000759 trimer interface [polypeptide binding]; other site 336982000760 active site 336982000761 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 336982000762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982000763 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 336982000764 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 336982000765 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 336982000766 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982000767 dimerization interface [polypeptide binding]; other site 336982000768 putative DNA binding site [nucleotide binding]; other site 336982000769 putative Zn2+ binding site [ion binding]; other site 336982000770 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 336982000771 active site residue [active] 336982000772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982000773 Cytochrome P450; Region: p450; cl12078 336982000774 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 336982000775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982000777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982000778 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 336982000779 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 336982000780 DinB superfamily; Region: DinB_2; cl00986 336982000781 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982000782 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 336982000783 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 336982000784 substrate binding site [chemical binding]; other site 336982000785 tetramer interface [polypeptide binding]; other site 336982000786 PE family; Region: PE; pfam00934 336982000787 Domain of unknown function DUF222; Region: DUF222; pfam02720 336982000788 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982000789 active site 336982000790 alanine aminotransferase; Provisional; Region: PTZ00377 336982000791 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982000792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982000793 homodimer interface [polypeptide binding]; other site 336982000794 catalytic residue [active] 336982000795 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 336982000796 Cysteine-rich domain; Region: CCG; pfam02754 336982000797 Cysteine-rich domain; Region: CCG; pfam02754 336982000798 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 336982000799 DNA binding residues [nucleotide binding] 336982000800 dimerization interface [polypeptide binding]; other site 336982000801 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 336982000802 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 336982000803 GTP/Mg2+ binding site [chemical binding]; other site 336982000804 Switch I region; other site 336982000805 G2 box; other site 336982000806 Switch II region; other site 336982000807 G3 box; other site 336982000808 G4 box; other site 336982000809 G5 box; other site 336982000810 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 336982000811 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 336982000812 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982000813 active site 336982000814 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 336982000815 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 336982000816 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 336982000817 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 336982000818 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 336982000819 dimer interface [polypeptide binding]; other site 336982000820 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 336982000821 chaperone protein DnaJ; Provisional; Region: PRK14279 336982000822 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 336982000823 HSP70 interaction site [polypeptide binding]; other site 336982000824 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 336982000825 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 336982000826 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 336982000827 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 336982000828 DNA binding residues [nucleotide binding] 336982000829 putative dimer interface [polypeptide binding]; other site 336982000830 PPE family; Region: PPE; pfam00823 336982000831 Sec24-related protein; Provisional; Region: PTZ00395 336982000832 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982000833 Sec24-related protein; Provisional; Region: PTZ00395 336982000834 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 336982000835 CoenzymeA binding site [chemical binding]; other site 336982000836 subunit interaction site [polypeptide binding]; other site 336982000837 PHB binding site; other site 336982000838 adenylosuccinate synthetase; Provisional; Region: PRK01117 336982000839 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 336982000840 GDP-binding site [chemical binding]; other site 336982000841 ACT binding site; other site 336982000842 IMP binding site; other site 336982000843 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 336982000844 active site 336982000845 putative substrate binding region [chemical binding]; other site 336982000846 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 336982000847 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 336982000848 MgtE intracellular N domain; Region: MgtE_N; cl15244 336982000849 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 336982000850 Divalent cation transporter; Region: MgtE; cl00786 336982000851 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 336982000852 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 336982000853 active site 336982000854 intersubunit interface [polypeptide binding]; other site 336982000855 zinc binding site [ion binding]; other site 336982000856 Na+ binding site [ion binding]; other site 336982000857 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 336982000858 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 336982000859 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 336982000860 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982000861 Predicted kinase [General function prediction only]; Region: COG0645 336982000862 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 336982000863 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 336982000864 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 336982000865 putative hydrophobic ligand binding site [chemical binding]; other site 336982000866 MoxR-like ATPases [General function prediction only]; Region: COG0714 336982000867 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 336982000868 Ligand binding site [chemical binding]; other site 336982000869 metal binding site [ion binding]; metal-binding site 336982000870 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 336982000871 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 336982000872 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 336982000873 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 336982000874 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 336982000875 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 336982000876 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982000877 catalytic loop [active] 336982000878 iron binding site [ion binding]; other site 336982000879 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 336982000880 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 336982000881 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 336982000882 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 336982000883 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 336982000884 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 336982000885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 336982000886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982000887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982000888 Protein of unknown function (DUF1458); Region: DUF1458; cl01328 336982000889 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 336982000890 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 336982000891 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 336982000892 Clp amino terminal domain; Region: Clp_N; pfam02861 336982000893 Clp amino terminal domain; Region: Clp_N; pfam02861 336982000894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982000895 Walker A motif; other site 336982000896 ATP binding site [chemical binding]; other site 336982000897 Walker B motif; other site 336982000898 arginine finger; other site 336982000899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982000900 Walker A motif; other site 336982000901 ATP binding site [chemical binding]; other site 336982000902 Walker B motif; other site 336982000903 arginine finger; other site 336982000904 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 336982000905 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 336982000906 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 336982000907 heme-binding site [chemical binding]; other site 336982000908 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 336982000909 FAD binding pocket [chemical binding]; other site 336982000910 FAD binding motif [chemical binding]; other site 336982000911 phosphate binding motif [ion binding]; other site 336982000912 beta-alpha-beta structure motif; other site 336982000913 NAD binding pocket [chemical binding]; other site 336982000914 cyclase homology domain; Region: CHD; cd07302 336982000915 nucleotidyl binding site; other site 336982000916 metal binding site [ion binding]; metal-binding site 336982000917 dimer interface [polypeptide binding]; other site 336982000918 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982000919 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 336982000920 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 336982000921 DNA binding residues [nucleotide binding] 336982000922 PPE family; Region: PPE; pfam00823 336982000923 phosphoribosylglycinamide formyltransferase 2; Region: purT; TIGR01142 336982000924 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 336982000925 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 336982000926 active site residue [active] 336982000927 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 336982000928 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 336982000929 homodimer interface [polypeptide binding]; other site 336982000930 substrate-cofactor binding pocket; other site 336982000931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982000932 catalytic residue [active] 336982000933 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 336982000934 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982000935 Domain of unknown function DUF222; Region: DUF222; pfam02720 336982000936 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982000937 active site 336982000938 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982000939 Beta-lactamase; Region: Beta-lactamase; cl01009 336982000940 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 336982000941 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982000942 FAD binding site [chemical binding]; other site 336982000943 substrate binding pocket [chemical binding]; other site 336982000944 catalytic base [active] 336982000945 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 336982000946 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982000947 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 336982000948 acyl-CoA synthetase; Validated; Region: PRK05850 336982000949 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982000950 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982000951 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982000952 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 336982000953 active site 336982000954 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 336982000955 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982000956 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982000957 Thioesterase; Region: PKS_TE; smart00824 336982000958 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982000959 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 336982000960 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982000961 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982000962 phosphate acetyltransferase; Reviewed; Region: PRK05632 336982000963 DRTGG domain; Region: DRTGG; cl12147 336982000964 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 336982000965 Acetokinase family; Region: Acetate_kinase; cl01029 336982000966 Protein kinase domain; Region: Pkinase; pfam00069 336982000967 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982000968 active site 336982000969 ATP binding site [chemical binding]; other site 336982000970 substrate binding site [chemical binding]; other site 336982000971 activation loop (A-loop); other site 336982000972 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 336982000973 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 336982000974 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 336982000975 substrate binding pocket [chemical binding]; other site 336982000976 membrane-bound complex binding site; other site 336982000977 hinge residues; other site 336982000978 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 336982000979 nudix motif; other site 336982000980 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 336982000981 thiamine phosphate binding site [chemical binding]; other site 336982000982 active site 336982000983 pyrophosphate binding site [ion binding]; other site 336982000984 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982000985 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 336982000986 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 336982000987 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 336982000988 thiS-thiF/thiG interaction site; other site 336982000989 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 336982000990 ThiS interaction site; other site 336982000991 putative active site [active] 336982000992 tetramer interface [polypeptide binding]; other site 336982000993 M28, and M42; Region: Zinc_peptidase_like; cl14876 336982000994 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 336982000995 PA/protease or protease-like domain interface [polypeptide binding]; other site 336982000996 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 336982000997 active site 336982000998 metal binding site [ion binding]; metal-binding site 336982000999 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 336982001000 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 336982001001 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 336982001002 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 336982001003 dimer interface [polypeptide binding]; other site 336982001004 substrate binding site [chemical binding]; other site 336982001005 ATP binding site [chemical binding]; other site 336982001006 ThiC family; Region: ThiC; cl08031 336982001007 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 336982001008 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982001009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982001010 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 336982001011 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 336982001012 putative phosphate binding site [ion binding]; other site 336982001013 putative catalytic site [active] 336982001014 active site 336982001015 metal binding site A [ion binding]; metal-binding site 336982001016 DNA binding site [nucleotide binding] 336982001017 putative AP binding site [nucleotide binding]; other site 336982001018 putative metal binding site B [ion binding]; other site 336982001019 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 336982001020 active site 336982001021 catalytic residues [active] 336982001022 metal binding site [ion binding]; metal-binding site 336982001023 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 336982001024 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 336982001025 E-class dimer interface [polypeptide binding]; other site 336982001026 P-class dimer interface [polypeptide binding]; other site 336982001027 active site 336982001028 Cu2+ binding site [ion binding]; other site 336982001029 Zn2+ binding site [ion binding]; other site 336982001030 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 336982001031 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 336982001032 Found in ATP-dependent protease La (LON); Region: LON; cl01056 336982001033 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 336982001034 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 336982001035 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 336982001036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982001037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982001038 Walker A motif; other site 336982001039 ATP binding site [chemical binding]; other site 336982001040 Walker B motif; other site 336982001041 arginine finger; other site 336982001042 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 336982001043 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 336982001044 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 336982001045 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 336982001046 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 336982001047 dimer interface [polypeptide binding]; other site 336982001048 putative functional site; other site 336982001049 putative MPT binding site; other site 336982001050 short chain dehydrogenase; Provisional; Region: PRK06197 336982001051 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 336982001052 putative NAD(P) binding site [chemical binding]; other site 336982001053 active site 336982001054 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 336982001055 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 336982001056 ring oligomerisation interface [polypeptide binding]; other site 336982001057 ATP/Mg binding site [chemical binding]; other site 336982001058 stacking interactions; other site 336982001059 hinge regions; other site 336982001060 PPE family; Region: PPE; pfam00823 336982001061 DinB superfamily; Region: DinB_2; cl00986 336982001062 Anti-sigma-K factor rskA; Region: RskA; cl02208 336982001063 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 336982001064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982001065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 336982001066 DNA binding residues [nucleotide binding] 336982001067 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 336982001068 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 336982001069 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982001071 Protein of unknown function (DUF1365); Region: DUF1365; cl01388 336982001072 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 336982001073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982001074 Transport protein; Region: actII; TIGR00833 336982001075 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 336982001076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982001077 PPE family; Region: PPE; pfam00823 336982001078 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 336982001079 enoyl-CoA hydratase; Provisional; Region: PRK12478 336982001080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982001081 substrate binding site [chemical binding]; other site 336982001082 oxyanion hole (OAH) forming residues; other site 336982001083 trimer interface [polypeptide binding]; other site 336982001084 PemK-like protein; Region: PemK; cl00995 336982001085 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 336982001086 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982001087 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 336982001088 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982001089 NAD(P) binding site [chemical binding]; other site 336982001090 catalytic residues [active] 336982001091 Protein of unknown function (DUF779); Region: DUF779; cl01432 336982001092 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 336982001093 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982001094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982001095 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 336982001096 Uncharacterized conserved protein [Function unknown]; Region: COG2128 336982001097 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 336982001098 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 336982001099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982001100 non-specific DNA binding site [nucleotide binding]; other site 336982001101 salt bridge; other site 336982001102 sequence-specific DNA binding site [nucleotide binding]; other site 336982001103 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 336982001104 Domain of unknown function (DUF955); Region: DUF955; cl01076 336982001105 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 336982001106 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 336982001107 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 336982001108 active site 336982001109 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 336982001110 active site 2 [active] 336982001111 active site 1 [active] 336982001112 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 336982001113 oligomerization interface [polypeptide binding]; other site 336982001114 active site 336982001115 metal binding site [ion binding]; metal-binding site 336982001116 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 336982001117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982001118 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 336982001119 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982001121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982001122 S-adenosylmethionine binding site [chemical binding]; other site 336982001123 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982001125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982001126 S-adenosylmethionine binding site [chemical binding]; other site 336982001127 UbiA prenyltransferase family; Region: UbiA; cl00337 336982001128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982001129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982001130 Predicted membrane protein [Function unknown]; Region: COG2733 336982001131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982001132 non-specific DNA binding site [nucleotide binding]; other site 336982001133 salt bridge; other site 336982001134 sequence-specific DNA binding site [nucleotide binding]; other site 336982001135 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 336982001136 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 336982001137 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 336982001138 intersubunit interface [polypeptide binding]; other site 336982001139 active site 336982001140 catalytic residue [active] 336982001141 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 336982001142 putative active site [active] 336982001143 catalytic triad [active] 336982001144 putative dimer interface [polypeptide binding]; other site 336982001145 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 336982001146 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 336982001147 FAD binding domain; Region: FAD_binding_4; pfam01565 336982001148 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 336982001149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 336982001150 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 336982001151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982001152 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 336982001153 NAD(P) binding site [chemical binding]; other site 336982001154 active site 336982001155 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 336982001156 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 336982001157 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 336982001158 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 336982001159 putative ADP-binding pocket [chemical binding]; other site 336982001160 Protein of unknown function (DUF2596); Region: DUF2596; pfam10770 336982001161 LysE type translocator; Region: LysE; cl00565 336982001162 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982001163 catalytic core [active] 336982001164 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 336982001165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 336982001166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 336982001167 dimer interface [polypeptide binding]; other site 336982001168 phosphorylation site [posttranslational modification] 336982001169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982001170 ATP binding site [chemical binding]; other site 336982001171 Mg2+ binding site [ion binding]; other site 336982001172 G-X-G motif; other site 336982001173 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982001174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 336982001175 active site 336982001176 phosphorylation site [posttranslational modification] 336982001177 intermolecular recognition site; other site 336982001178 dimerization interface [polypeptide binding]; other site 336982001179 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 336982001180 DNA binding site [nucleotide binding] 336982001181 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 336982001182 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 336982001183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982001184 DNA-binding site [nucleotide binding]; DNA binding site 336982001185 FCD domain; Region: FCD; cl11656 336982001186 exopolyphosphatase; Region: exo_poly_only; TIGR03706 336982001187 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 336982001188 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 336982001189 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 336982001190 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 336982001191 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 336982001192 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 336982001193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982001194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982001195 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 336982001196 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 336982001197 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 336982001198 putative NAD(P) binding site [chemical binding]; other site 336982001199 active site 336982001200 putative substrate binding site [chemical binding]; other site 336982001201 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 336982001202 putative acyl-acceptor binding pocket; other site 336982001203 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982001205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982001206 S-adenosylmethionine binding site [chemical binding]; other site 336982001207 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 336982001208 active site 336982001209 catalytic site [active] 336982001210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982001211 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 336982001212 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 336982001213 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982001214 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 336982001215 glutamyl-tRNA reductase; Region: hemA; TIGR01035 336982001216 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 336982001217 tRNA; other site 336982001218 putative tRNA binding site [nucleotide binding]; other site 336982001219 putative NADP binding site [chemical binding]; other site 336982001220 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 336982001221 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 336982001222 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 336982001223 domain interfaces; other site 336982001224 active site 336982001225 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 336982001226 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 336982001227 active site 336982001228 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 336982001229 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 336982001230 dimer interface [polypeptide binding]; other site 336982001231 active site 336982001232 Schiff base residues; other site 336982001233 Domain of unknown function DUF222; Region: DUF222; pfam02720 336982001234 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982001235 active site 336982001236 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 336982001237 anti sigma factor interaction site; other site 336982001238 regulatory phosphorylation site [posttranslational modification]; other site 336982001239 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 336982001240 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 336982001241 active site 336982001242 catalytic triad [active] 336982001243 oxyanion hole [active] 336982001244 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 336982001245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982001246 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 336982001247 Amino acid permease; Region: AA_permease; pfam00324 336982001248 Domain of unknown function (DUF385); Region: DUF385; cl04387 336982001249 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 336982001250 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982001251 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982001252 catalytic residue [active] 336982001253 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982001254 catalytic core [active] 336982001255 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 336982001256 catalytic residues [active] 336982001257 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 336982001258 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 336982001259 ResB-like family; Region: ResB; pfam05140 336982001260 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 336982001261 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 336982001262 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 336982001263 P-loop; other site 336982001264 Magnesium ion binding site [ion binding]; other site 336982001265 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 336982001266 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 336982001267 dimer interface [polypeptide binding]; other site 336982001268 active site 336982001269 CoA binding pocket [chemical binding]; other site 336982001270 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 336982001271 UbiA prenyltransferase family; Region: UbiA; cl00337 336982001272 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 336982001273 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 336982001274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982001275 NAD(P) binding site [chemical binding]; other site 336982001276 active site 336982001277 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 336982001278 Ligand binding site [chemical binding]; other site 336982001279 Putative Catalytic site [active] 336982001280 DXD motif; other site 336982001281 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982001282 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982001283 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 336982001284 Phosphate transporter family; Region: PHO4; cl00396 336982001285 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 336982001286 active site 336982001287 short chain dehydrogenase; Provisional; Region: PRK05866 336982001288 classical (c) SDRs; Region: SDR_c; cd05233 336982001289 NAD(P) binding site [chemical binding]; other site 336982001290 active site 336982001291 naphthoate synthase; Validated; Region: PRK08321 336982001292 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982001293 substrate binding site [chemical binding]; other site 336982001294 oxyanion hole (OAH) forming residues; other site 336982001295 trimer interface [polypeptide binding]; other site 336982001296 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 336982001297 putative active site [active] 336982001298 homotetrameric interface [polypeptide binding]; other site 336982001299 metal binding site [ion binding]; metal-binding site 336982001300 acyl-CoA synthetase; Validated; Region: PRK06188 336982001301 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982001302 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 336982001303 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 336982001304 active site 336982001305 O-succinylbenzoate synthase; Provisional; Region: PRK02901 336982001306 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway...; Region: OSBS; cd03320 336982001307 active site 336982001308 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982001309 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982001310 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 336982001311 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 336982001312 dimer interface [polypeptide binding]; other site 336982001313 tetramer interface [polypeptide binding]; other site 336982001314 PYR/PP interface [polypeptide binding]; other site 336982001315 TPP binding site [chemical binding]; other site 336982001316 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 336982001317 TPP-binding site; other site 336982001318 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 336982001319 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 336982001320 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 336982001321 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 336982001322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982001323 S-adenosylmethionine binding site [chemical binding]; other site 336982001324 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982001325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982001326 S-adenosylmethionine binding site [chemical binding]; other site 336982001327 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 336982001328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982001329 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 336982001330 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 336982001331 substrate binding pocket [chemical binding]; other site 336982001332 chain length determination region; other site 336982001333 substrate-Mg2+ binding site; other site 336982001334 catalytic residues [active] 336982001335 aspartate-rich region 1; other site 336982001336 active site lid residues [active] 336982001337 aspartate-rich region 2; other site 336982001338 Peptidase family M48; Region: Peptidase_M48; cl12018 336982001339 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 336982001340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982001341 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 336982001342 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982001343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982001344 Protein of unknown function (DUF520); Region: DUF520; cl00723 336982001345 O-methyltransferase; Region: Methyltransf_2; pfam00891 336982001346 Cytochrome P450; Region: p450; cl12078 336982001347 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 336982001348 ATP cone domain; Region: ATP-cone; pfam03477 336982001349 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 336982001350 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 336982001351 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 336982001352 active site 336982001353 dimer interface [polypeptide binding]; other site 336982001354 effector binding site; other site 336982001355 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 336982001356 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 336982001357 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 336982001358 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 336982001359 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 336982001360 active site 336982001361 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 336982001362 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 336982001363 putative active site [active] 336982001364 putative metal binding site [ion binding]; other site 336982001365 hypothetical protein; Provisional; Region: PRK07588 336982001366 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982001367 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982001368 dimerization interface [polypeptide binding]; other site 336982001369 putative DNA binding site [nucleotide binding]; other site 336982001370 putative Zn2+ binding site [ion binding]; other site 336982001371 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 336982001372 putative hydrophobic ligand binding site [chemical binding]; other site 336982001373 TIGR03086 family protein; Region: TIGR03086 336982001374 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 336982001375 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 336982001376 PE family; Region: PE; pfam00934 336982001377 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 336982001378 Protein of unknown function DUF82; Region: DUF82; pfam01927 336982001379 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 336982001380 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982001381 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 336982001382 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 336982001383 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 336982001384 Predicted integral membrane protein [Function unknown]; Region: COG0392 336982001385 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 336982001386 Transcriptional regulators [Transcription]; Region: FadR; COG2186 336982001387 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982001388 DNA-binding site [nucleotide binding]; DNA binding site 336982001389 FCD domain; Region: FCD; cl11656 336982001390 Domain of unknown function DUF140; Region: DUF140; cl00510 336982001391 Domain of unknown function DUF140; Region: DUF140; cl00510 336982001392 mce related protein; Region: MCE; cl03606 336982001393 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 336982001394 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982001395 mce related protein; Region: MCE; cl03606 336982001396 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982001397 mce related protein; Region: MCE; cl03606 336982001398 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982001399 mce related protein; Region: MCE; cl03606 336982001400 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982001401 mce related protein; Region: MCE; cl03606 336982001402 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982001403 mce related protein; Region: MCE; cl03606 336982001404 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 336982001405 oligomeric interface; other site 336982001406 putative active site [active] 336982001407 homodimer interface [polypeptide binding]; other site 336982001408 Phd_YefM; Region: PhdYeFM; cl09153 336982001409 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 336982001410 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 336982001411 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 336982001412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982001413 ATP binding site [chemical binding]; other site 336982001414 Mg2+ binding site [ion binding]; other site 336982001415 G-X-G motif; other site 336982001416 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982001417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 336982001418 active site 336982001419 phosphorylation site [posttranslational modification] 336982001420 intermolecular recognition site; other site 336982001421 dimerization interface [polypeptide binding]; other site 336982001422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 336982001423 DNA binding site [nucleotide binding] 336982001424 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 336982001425 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 336982001426 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 336982001427 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 336982001428 catalytic residues [active] 336982001429 catalytic nucleophile [active] 336982001430 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 336982001431 Probable transposase; Region: OrfB_IS605; pfam01385 336982001432 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 336982001433 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 336982001434 putative active site [active] 336982001435 SEC-C motif; Region: SEC-C; cl12132 336982001436 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 336982001437 putative active site [active] 336982001438 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 336982001439 nucleotide binding site/active site [active] 336982001440 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 336982001441 galactokinase; Provisional; Region: PRK00555 336982001442 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 336982001443 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982001444 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 336982001445 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 336982001446 putative active site [active] 336982001447 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 336982001448 Phd_YefM; Region: PhdYeFM; cl09153 336982001449 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 336982001450 oligomeric interface; other site 336982001451 putative active site [active] 336982001452 homodimer interface [polypeptide binding]; other site 336982001453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 336982001454 FIST N domain; Region: FIST; pfam08495 336982001455 FIST C domain; Region: FIST_C; pfam10442 336982001456 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 336982001457 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 336982001458 UvrD/REP helicase; Region: UvrD-helicase; cl14126 336982001459 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 336982001460 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 336982001461 enoyl-CoA hydratase; Provisional; Region: PRK06213 336982001462 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982001463 substrate binding site [chemical binding]; other site 336982001464 oxyanion hole (OAH) forming residues; other site 336982001465 trimer interface [polypeptide binding]; other site 336982001466 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982001467 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 336982001468 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 336982001469 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 336982001470 active site 336982001471 catalytic site [active] 336982001472 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 336982001473 active site 336982001474 catalytic site [active] 336982001475 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 336982001476 active site 336982001477 catalytic site [active] 336982001478 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 336982001479 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 336982001480 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 336982001481 putative homodimer interface [polypeptide binding]; other site 336982001482 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 336982001483 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 336982001484 23S rRNA interface [nucleotide binding]; other site 336982001485 L7/L12 interface [polypeptide binding]; other site 336982001486 putative thiostrepton binding site; other site 336982001487 L25 interface [polypeptide binding]; other site 336982001488 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 336982001489 mRNA/rRNA interface [nucleotide binding]; other site 336982001490 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982001492 S-adenosylmethionine binding site [chemical binding]; other site 336982001493 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982001495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982001496 S-adenosylmethionine binding site [chemical binding]; other site 336982001497 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982001499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982001500 S-adenosylmethionine binding site [chemical binding]; other site 336982001501 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982001502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982001503 S-adenosylmethionine binding site [chemical binding]; other site 336982001504 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982001505 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 336982001506 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 336982001507 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 336982001508 active site 336982001509 ATP binding site [chemical binding]; other site 336982001510 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 336982001511 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 336982001512 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 336982001513 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 336982001514 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 336982001515 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 336982001516 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 336982001517 N-acetylmannosamine kinase; Provisional; Region: PRK05082 336982001518 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 336982001519 23S rRNA interface [nucleotide binding]; other site 336982001520 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 336982001521 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 336982001522 core dimer interface [polypeptide binding]; other site 336982001523 peripheral dimer interface [polypeptide binding]; other site 336982001524 L10 interface [polypeptide binding]; other site 336982001525 L11 interface [polypeptide binding]; other site 336982001526 putative EF-Tu interaction site [polypeptide binding]; other site 336982001527 putative EF-G interaction site [polypeptide binding]; other site 336982001528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982001529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982001530 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 336982001531 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 336982001532 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 336982001533 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 336982001534 Walker A/P-loop; other site 336982001535 ATP binding site [chemical binding]; other site 336982001536 Q-loop/lid; other site 336982001537 ABC transporter signature motif; other site 336982001538 Walker B; other site 336982001539 D-loop; other site 336982001540 H-loop/switch region; other site 336982001541 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982001542 putative active site [active] 336982001543 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 336982001544 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 336982001545 PemK-like protein; Region: PemK; cl00995 336982001546 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982001547 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 336982001548 Sulfatase; Region: Sulfatase; cl10460 336982001549 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982001550 putative active site [active] 336982001551 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 336982001552 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 336982001553 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 336982001554 RPB10 interaction site [polypeptide binding]; other site 336982001555 RPB1 interaction site [polypeptide binding]; other site 336982001556 RPB11 interaction site [polypeptide binding]; other site 336982001557 RPB3 interaction site [polypeptide binding]; other site 336982001558 RPB12 interaction site [polypeptide binding]; other site 336982001559 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 336982001560 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 336982001561 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 336982001562 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 336982001563 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 336982001564 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 336982001565 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 336982001566 G-loop; other site 336982001567 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 336982001568 DNA binding site [nucleotide binding] 336982001569 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 336982001570 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 336982001571 endonuclease IV; Provisional; Region: PRK01060 336982001572 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 336982001573 AP (apurinic/apyrimidinic) site pocket; other site 336982001574 DNA interaction; other site 336982001575 Metal-binding active site; metal-binding site 336982001576 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 336982001577 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982001578 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 336982001579 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982001580 active site 336982001581 enoyl-CoA hydratase; Provisional; Region: PRK08272 336982001582 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982001583 substrate binding site [chemical binding]; other site 336982001584 oxyanion hole (OAH) forming residues; other site 336982001585 trimer interface [polypeptide binding]; other site 336982001586 PaaX-like protein; Region: PaaX; pfam07848 336982001587 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 336982001588 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982001589 substrate binding site [chemical binding]; other site 336982001590 oxyanion hole (OAH) forming residues; other site 336982001591 trimer interface [polypeptide binding]; other site 336982001592 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982001593 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 336982001594 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 336982001595 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 336982001596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982001597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982001598 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 336982001599 S17 interaction site [polypeptide binding]; other site 336982001600 S8 interaction site; other site 336982001601 16S rRNA interaction site [nucleotide binding]; other site 336982001602 streptomycin interaction site [chemical binding]; other site 336982001603 23S rRNA interaction site [nucleotide binding]; other site 336982001604 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 336982001605 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 336982001606 elongation factor G; Reviewed; Region: PRK00007 336982001607 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 336982001608 G1 box; other site 336982001609 putative GEF interaction site [polypeptide binding]; other site 336982001610 GTP/Mg2+ binding site [chemical binding]; other site 336982001611 Switch I region; other site 336982001612 G2 box; other site 336982001613 G3 box; other site 336982001614 Switch II region; other site 336982001615 G4 box; other site 336982001616 G5 box; other site 336982001617 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 336982001618 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 336982001619 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 336982001620 elongation factor Tu; Reviewed; Region: PRK00049 336982001621 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 336982001622 G1 box; other site 336982001623 GEF interaction site [polypeptide binding]; other site 336982001624 GTP/Mg2+ binding site [chemical binding]; other site 336982001625 Switch I region; other site 336982001626 G2 box; other site 336982001627 G3 box; other site 336982001628 Switch II region; other site 336982001629 G4 box; other site 336982001630 G5 box; other site 336982001631 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 336982001632 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 336982001633 Antibiotic Binding Site [chemical binding]; other site 336982001634 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 336982001635 classical (c) SDRs; Region: SDR_c; cd05233 336982001636 NAD(P) binding site [chemical binding]; other site 336982001637 active site 336982001638 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 336982001639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982001640 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 336982001641 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 336982001642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982001643 mycofactocin system RPExFGAL proteinn; Region: Ac_RPExFGAL; TIGR03967 336982001644 radical SAM peptide maturase, mycofactocin system; Region: rSAM_MSMEG_1423; TIGR03962 336982001645 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 336982001646 FeS/SAM binding site; other site 336982001647 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 336982001648 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 336982001649 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 336982001650 phosphate binding site [ion binding]; other site 336982001651 Creatinine amidohydrolase; Region: Creatininase; cl00618 336982001652 mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965 336982001653 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 336982001654 Probable Catalytic site [active] 336982001655 metal binding site [ion binding]; metal-binding site 336982001656 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 336982001657 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 336982001658 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 336982001659 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 336982001660 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 336982001661 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 336982001662 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 336982001663 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 336982001664 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 336982001665 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 336982001666 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 336982001667 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 336982001668 putative translocon binding site; other site 336982001669 protein-rRNA interface [nucleotide binding]; other site 336982001670 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 336982001671 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 336982001672 G-X-X-G motif; other site 336982001673 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 336982001674 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 336982001675 23S rRNA interface [nucleotide binding]; other site 336982001676 5S rRNA interface [nucleotide binding]; other site 336982001677 putative antibiotic binding site [chemical binding]; other site 336982001678 L25 interface [polypeptide binding]; other site 336982001679 L27 interface [polypeptide binding]; other site 336982001680 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 336982001681 putative translocon interaction site; other site 336982001682 23S rRNA interface [nucleotide binding]; other site 336982001683 signal recognition particle (SRP54) interaction site; other site 336982001684 L23 interface [polypeptide binding]; other site 336982001685 trigger factor interaction site; other site 336982001686 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 336982001687 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 336982001688 Sulfatase; Region: Sulfatase; cl10460 336982001689 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 336982001690 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 336982001691 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 336982001692 KOW motif; Region: KOW; cl00354 336982001693 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 336982001694 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 336982001695 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 336982001696 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 336982001697 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 336982001698 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 336982001699 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 336982001700 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 336982001701 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 336982001702 5S rRNA interface [nucleotide binding]; other site 336982001703 23S rRNA interface [nucleotide binding]; other site 336982001704 L5 interface [polypeptide binding]; other site 336982001705 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 336982001706 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 336982001707 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 336982001708 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 336982001709 23S rRNA binding site [nucleotide binding]; other site 336982001710 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 336982001711 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 336982001712 tandem repeat interface [polypeptide binding]; other site 336982001713 oligomer interface [polypeptide binding]; other site 336982001714 active site residues [active] 336982001715 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 336982001716 tandem repeat interface [polypeptide binding]; other site 336982001717 oligomer interface [polypeptide binding]; other site 336982001718 active site residues [active] 336982001719 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982001720 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982001721 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cd00398 336982001722 intersubunit interface [polypeptide binding]; other site 336982001723 active site 336982001724 Zn2+ binding site [ion binding]; other site 336982001725 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 336982001726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982001727 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 336982001728 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 336982001729 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 336982001730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982001731 Coenzyme A binding pocket [chemical binding]; other site 336982001732 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982001733 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 336982001734 SecY translocase; Region: SecY; pfam00344 336982001735 adenylate kinase; Reviewed; Region: adk; PRK00279 336982001736 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 336982001737 AMP-binding site [chemical binding]; other site 336982001738 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 336982001739 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 336982001740 active site 336982001741 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 336982001742 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982001743 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 336982001744 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 336982001745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982001746 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 336982001747 TIGR03086 family protein; Region: TIGR03086 336982001748 Biofilm regulator BssS; Region: BssS; pfam10774 336982001749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 336982001750 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 336982001751 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 336982001752 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982001753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982001754 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 336982001755 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982001756 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982001757 active site 336982001758 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 336982001759 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982001760 tetrameric interface [polypeptide binding]; other site 336982001761 NAD binding site [chemical binding]; other site 336982001762 catalytic residues [active] 336982001763 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 336982001764 PPE family; Region: PPE; pfam00823 336982001765 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982001766 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982001767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 336982001768 active site 336982001769 phosphorylation site [posttranslational modification] 336982001770 intermolecular recognition site; other site 336982001771 dimerization interface [polypeptide binding]; other site 336982001772 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 336982001773 DNA binding site [nucleotide binding] 336982001774 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 336982001775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 336982001776 dimer interface [polypeptide binding]; other site 336982001777 phosphorylation site [posttranslational modification] 336982001778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982001779 ATP binding site [chemical binding]; other site 336982001780 Mg2+ binding site [ion binding]; other site 336982001781 G-X-G motif; other site 336982001782 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 336982001783 nucleotide binding site/active site [active] 336982001784 HIT family signature motif; other site 336982001785 catalytic residue [active] 336982001786 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982001787 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 336982001788 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 336982001789 NAD binding site [chemical binding]; other site 336982001790 catalytic Zn binding site [ion binding]; other site 336982001791 substrate binding site [chemical binding]; other site 336982001792 structural Zn binding site [ion binding]; other site 336982001793 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 336982001794 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 336982001795 Cytochrome P450; Region: p450; cl12078 336982001796 classical (c) SDRs; Region: SDR_c; cd05233 336982001797 NAD(P) binding site [chemical binding]; other site 336982001798 active site 336982001799 Cytochrome P450; Region: p450; cl12078 336982001800 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982001801 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 336982001802 NAD binding site [chemical binding]; other site 336982001803 catalytic residues [active] 336982001804 short chain dehydrogenase; Provisional; Region: PRK07774 336982001805 classical (c) SDRs; Region: SDR_c; cd05233 336982001806 NAD(P) binding site [chemical binding]; other site 336982001807 active site 336982001808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982001809 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 336982001810 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 336982001811 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 336982001812 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 336982001813 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 336982001814 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 336982001815 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 336982001816 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 336982001817 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 336982001818 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982001819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 336982001820 Protein of unknown function (DUF429); Region: DUF429; cl12046 336982001821 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 336982001822 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 336982001823 tetramer interface [polypeptide binding]; other site 336982001824 active site 336982001825 Cytochrome P450; Region: p450; cl12078 336982001826 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 336982001827 ATP binding site [chemical binding]; other site 336982001828 active site 336982001829 substrate binding site [chemical binding]; other site 336982001830 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 336982001831 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982001832 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 336982001833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982001834 putative substrate translocation pore; other site 336982001835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982001836 Predicted deacetylase [General function prediction only]; Region: COG3233 336982001837 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982001838 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982001839 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 336982001840 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 336982001841 putative active site [active] 336982001842 catalytic triad [active] 336982001843 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 336982001844 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982001845 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 336982001846 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 336982001847 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982001848 DNA-binding site [nucleotide binding]; DNA binding site 336982001849 UTRA domain; Region: UTRA; cl06649 336982001850 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 336982001851 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 336982001852 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982001853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982001854 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 336982001855 Transposase; Region: DEDD_Tnp_IS110; pfam01548 336982001856 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 336982001857 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 336982001858 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 336982001859 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 336982001860 active site 336982001861 metal binding site [ion binding]; metal-binding site 336982001862 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 336982001863 active site 336982001864 metal binding site [ion binding]; metal-binding site 336982001865 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 336982001866 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 336982001867 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 336982001868 dimerization interface [polypeptide binding]; other site 336982001869 ATP binding site [chemical binding]; other site 336982001870 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 336982001871 dimerization interface [polypeptide binding]; other site 336982001872 ATP binding site [chemical binding]; other site 336982001873 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 336982001874 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 336982001875 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 336982001876 active site 336982001877 metal binding site [ion binding]; metal-binding site 336982001878 hexamer interface [polypeptide binding]; other site 336982001879 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 336982001880 amidophosphoribosyltransferase; Provisional; Region: PRK07847 336982001881 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 336982001882 active site 336982001883 tetramer interface [polypeptide binding]; other site 336982001884 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 336982001885 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 336982001886 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 336982001887 dimerization interface [polypeptide binding]; other site 336982001888 putative ATP binding site [chemical binding]; other site 336982001889 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 336982001890 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 336982001891 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 336982001892 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 336982001893 Aminotransferase class IV; Region: Aminotran_4; pfam01063 336982001894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982001895 catalytic residue [active] 336982001896 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 336982001897 heme-binding site [chemical binding]; other site 336982001898 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 336982001899 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 336982001900 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 336982001901 active site residue [active] 336982001902 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 336982001903 active site residue [active] 336982001904 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 336982001905 catalytic residues [active] 336982001906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 336982001907 DNA binding site [nucleotide binding] 336982001908 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 336982001909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 336982001910 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 336982001911 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 336982001912 Walker A/P-loop; other site 336982001913 ATP binding site [chemical binding]; other site 336982001914 Q-loop/lid; other site 336982001915 ABC transporter signature motif; other site 336982001916 Walker B; other site 336982001917 D-loop; other site 336982001918 H-loop/switch region; other site 336982001919 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 336982001920 PhoU domain; Region: PhoU; pfam01895 336982001921 PhoU domain; Region: PhoU; pfam01895 336982001922 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 336982001923 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 336982001924 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 336982001925 FMN binding site [chemical binding]; other site 336982001926 active site 336982001927 catalytic residues [active] 336982001928 substrate binding site [chemical binding]; other site 336982001929 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 336982001930 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 336982001931 homodimer interface [polypeptide binding]; other site 336982001932 putative substrate binding pocket [chemical binding]; other site 336982001933 diiron center [ion binding]; other site 336982001934 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 336982001935 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982001936 dimerization interface [polypeptide binding]; other site 336982001937 putative DNA binding site [nucleotide binding]; other site 336982001938 putative Zn2+ binding site [ion binding]; other site 336982001939 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 336982001940 dimer interface [polypeptide binding]; other site 336982001941 catalytic motif [active] 336982001942 nucleoside/Zn binding site; other site 336982001943 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 336982001944 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982001945 PE family; Region: PE; pfam00934 336982001946 PE family; Region: PE; pfam00934 336982001947 putative transposase OrfB; Reviewed; Region: PHA02517 336982001948 Integrase core domain; Region: rve; cl01316 336982001949 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982001950 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 336982001951 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; cl02021 336982001952 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 336982001953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982001954 S-adenosylmethionine binding site [chemical binding]; other site 336982001955 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 336982001956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982001957 putative substrate translocation pore; other site 336982001958 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 336982001959 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 336982001960 tetramer interface [polypeptide binding]; other site 336982001961 TPP-binding site [chemical binding]; other site 336982001962 heterodimer interface [polypeptide binding]; other site 336982001963 phosphorylation loop region [posttranslational modification] 336982001964 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 336982001965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 336982001966 active site 336982001967 phosphorylation site [posttranslational modification] 336982001968 intermolecular recognition site; other site 336982001969 dimerization interface [polypeptide binding]; other site 336982001970 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 336982001971 DNA binding residues [nucleotide binding] 336982001972 dimerization interface [polypeptide binding]; other site 336982001973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 336982001974 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 336982001975 Multicopper oxidase; Region: Cu-oxidase; cl14658 336982001976 Multicopper oxidase; Region: Cu-oxidase; cl14658 336982001977 Multicopper oxidase; Region: Cu-oxidase; cl14658 336982001978 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 336982001979 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 336982001980 dimer interface [polypeptide binding]; other site 336982001981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982001982 catalytic residue [active] 336982001983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982001984 multidrug resistance protein MdtH; Provisional; Region: PRK11646 336982001985 putative substrate translocation pore; other site 336982001986 hypothetical protein; Provisional; Region: PRK06194 336982001987 classical (c) SDRs; Region: SDR_c; cd05233 336982001988 NAD(P) binding site [chemical binding]; other site 336982001989 active site 336982001990 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 336982001991 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 336982001992 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 336982001993 dimer interface [polypeptide binding]; other site 336982001994 PYR/PP interface [polypeptide binding]; other site 336982001995 TPP binding site [chemical binding]; other site 336982001996 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 336982001997 TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of pyruvate to acetaldehyde and CO2. It is able to utilize...; Region: TPP_PDC_IPDC; cd02005 336982001998 TPP-binding site [chemical binding]; other site 336982001999 dimer interface [polypeptide binding]; other site 336982002000 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 336982002001 putative hydrophobic ligand binding site [chemical binding]; other site 336982002002 CoA-transferase family III; Region: CoA_transf_3; cl00778 336982002003 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 336982002004 putative hydrophobic ligand binding site [chemical binding]; other site 336982002005 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 336982002006 putative hydrophobic ligand binding site [chemical binding]; other site 336982002007 hypothetical protein; Provisional; Region: PRK08912 336982002008 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982002009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982002010 homodimer interface [polypeptide binding]; other site 336982002011 catalytic residue [active] 336982002012 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 336982002013 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 336982002014 dimer interface [polypeptide binding]; other site 336982002015 active site 336982002016 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 336982002017 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982002018 substrate binding site [chemical binding]; other site 336982002019 oxyanion hole (OAH) forming residues; other site 336982002020 trimer interface [polypeptide binding]; other site 336982002021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982002022 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 336982002023 DNA repair helicase rad25; Region: rad25; TIGR00603 336982002024 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 336982002025 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982002026 ATP binding site [chemical binding]; other site 336982002027 putative Mg++ binding site [ion binding]; other site 336982002028 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982002029 nucleotide binding region [chemical binding]; other site 336982002030 ATP-binding site [chemical binding]; other site 336982002031 Predicted transcriptional regulator [Transcription]; Region: COG2378 336982002032 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 336982002033 trimer interface [polypeptide binding]; other site 336982002034 dimer interface [polypeptide binding]; other site 336982002035 putative active site [active] 336982002036 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 336982002037 MPT binding site; other site 336982002038 trimer interface [polypeptide binding]; other site 336982002039 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 336982002040 MoaE homodimer interface [polypeptide binding]; other site 336982002041 MoaD interaction [polypeptide binding]; other site 336982002042 active site residues [active] 336982002043 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 336982002044 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 336982002045 MoaE interaction surface [polypeptide binding]; other site 336982002046 MoeB interaction surface [polypeptide binding]; other site 336982002047 thiocarboxylated glycine; other site 336982002048 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 336982002049 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 336982002050 FeS/SAM binding site; other site 336982002051 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 336982002052 hypothetical protein; Provisional; Region: PRK11770 336982002053 Domain of unknown function (DUF307); Region: DUF307; pfam03733 336982002054 Domain of unknown function (DUF307); Region: DUF307; pfam03733 336982002055 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 336982002056 DNA-binding site [nucleotide binding]; DNA binding site 336982002057 RNA-binding motif; other site 336982002058 PE family; Region: PE; pfam00934 336982002059 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982002060 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982002061 active site 336982002062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 336982002063 FIST N domain; Region: FIST; pfam08495 336982002064 FIST C domain; Region: FIST_C; pfam10442 336982002065 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 336982002066 H+ Antiporter protein; Region: 2A0121; TIGR00900 336982002067 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 336982002068 PPE family; Region: PPE; pfam00823 336982002069 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982002070 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982002071 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 336982002072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982002073 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 336982002074 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 336982002075 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 336982002076 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 336982002077 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982002078 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982002079 catalytic residue [active] 336982002080 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 336982002081 Ferredoxin [Energy production and conversion]; Region: COG1146 336982002082 4Fe-4S binding domain; Region: Fer4; cl02805 336982002083 ferredoxin-NADP+ reductase; Region: PLN02852 336982002084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982002085 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 336982002086 putative dimer interface [polypeptide binding]; other site 336982002087 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 336982002088 putative catalytic site [active] 336982002089 putative phosphate binding site [ion binding]; other site 336982002090 putative metal binding site [ion binding]; other site 336982002091 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 336982002092 dimer interface [polypeptide binding]; other site 336982002093 Citrate synthase; Region: Citrate_synt; pfam00285 336982002094 active site 336982002095 citrylCoA binding site [chemical binding]; other site 336982002096 oxalacetate/citrate binding site [chemical binding]; other site 336982002097 coenzyme A binding site [chemical binding]; other site 336982002098 catalytic triad [active] 336982002099 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982002100 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 336982002101 DNA binding residues [nucleotide binding] 336982002102 dimerization interface [polypeptide binding]; other site 336982002103 cyclase homology domain; Region: CHD; cd07302 336982002104 nucleotidyl binding site; other site 336982002105 metal binding site [ion binding]; metal-binding site 336982002106 dimer interface [polypeptide binding]; other site 336982002107 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982002108 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982002109 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 336982002110 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982002111 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982002112 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982002113 Condensation domain; Region: Condensation; cl09290 336982002114 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 336982002115 dimer interface [polypeptide binding]; other site 336982002116 Citrate synthase; Region: Citrate_synt; pfam00285 336982002117 active site 336982002118 citrylCoA binding site [chemical binding]; other site 336982002119 NADH binding [chemical binding]; other site 336982002120 cationic pore residues; other site 336982002121 oxalacetate/citrate binding site [chemical binding]; other site 336982002122 coenzyme A binding site [chemical binding]; other site 336982002123 catalytic triad [active] 336982002124 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 336982002125 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 336982002126 BON domain; Region: BON; cl02771 336982002127 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 336982002128 ligand binding site [chemical binding]; other site 336982002129 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 336982002130 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 336982002131 dimerization interface [polypeptide binding]; other site 336982002132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 336982002133 dimer interface [polypeptide binding]; other site 336982002134 phosphorylation site [posttranslational modification] 336982002135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 336982002136 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982002137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 336982002138 active site 336982002139 phosphorylation site [posttranslational modification] 336982002140 intermolecular recognition site; other site 336982002141 dimerization interface [polypeptide binding]; other site 336982002142 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 336982002143 DNA binding site [nucleotide binding] 336982002144 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 336982002145 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 336982002146 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 336982002147 enoyl-CoA hydratase; Provisional; Region: PRK07854 336982002148 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982002149 substrate binding site [chemical binding]; other site 336982002150 oxyanion hole (OAH) forming residues; other site 336982002151 trimer interface [polypeptide binding]; other site 336982002152 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982002153 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982002154 Beta-lactamase; Region: Beta-lactamase; cl01009 336982002155 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 336982002156 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 336982002157 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982002158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982002159 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 336982002160 hydrophobic ligand binding site; other site 336982002161 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 336982002162 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 336982002163 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 336982002164 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 336982002165 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 336982002166 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 336982002167 active site 336982002168 PPE family; Region: PPE; pfam00823 336982002169 PE family; Region: PE; pfam00934 336982002170 BCCT family transporter; Region: BCCT; cl00569 336982002171 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 336982002172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 336982002173 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982002174 MULE transposase domain; Region: MULE; pfam10551 336982002175 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 336982002176 catalytic residues [active] 336982002177 catalytic nucleophile [active] 336982002178 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 336982002179 Probable transposase; Region: OrfB_IS605; pfam01385 336982002180 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 336982002181 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 336982002182 putative active site pocket [active] 336982002183 dimerization interface [polypeptide binding]; other site 336982002184 putative catalytic residue [active] 336982002185 Protein of unknown function (DUF867); Region: DUF867; cl01713 336982002186 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 336982002187 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 336982002188 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 336982002189 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 336982002190 classical (c) SDRs; Region: SDR_c; cd05233 336982002191 NAD(P) binding site [chemical binding]; other site 336982002192 active site 336982002193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982002194 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 336982002195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982002196 dimer interface [polypeptide binding]; other site 336982002197 conserved gate region; other site 336982002198 putative PBP binding loops; other site 336982002199 ABC-ATPase subunit interface; other site 336982002200 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 336982002201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982002202 dimer interface [polypeptide binding]; other site 336982002203 conserved gate region; other site 336982002204 putative PBP binding loops; other site 336982002205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 336982002206 ABC-ATPase subunit interface; other site 336982002207 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982002208 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982002209 active site 336982002210 ATP binding site [chemical binding]; other site 336982002211 substrate binding site [chemical binding]; other site 336982002212 activation loop (A-loop); other site 336982002213 Uncharacterized conserved protein [Function unknown]; Region: COG3391 336982002214 NHL repeat; Region: NHL; pfam01436 336982002215 NHL repeat; Region: NHL; pfam01436 336982002216 NHL repeat; Region: NHL; pfam01436 336982002217 NHL repeat; Region: NHL; pfam01436 336982002218 NHL repeat; Region: NHL; pfam01436 336982002219 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982002220 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 336982002221 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 336982002222 Walker A/P-loop; other site 336982002223 ATP binding site [chemical binding]; other site 336982002224 Q-loop/lid; other site 336982002225 ABC transporter signature motif; other site 336982002226 Walker B; other site 336982002227 D-loop; other site 336982002228 H-loop/switch region; other site 336982002229 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982002230 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 336982002231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 336982002232 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 336982002233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982002234 dimer interface [polypeptide binding]; other site 336982002235 conserved gate region; other site 336982002236 putative PBP binding loops; other site 336982002237 ABC-ATPase subunit interface; other site 336982002238 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 336982002239 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 336982002240 putative DNA binding site [nucleotide binding]; other site 336982002241 putative homodimer interface [polypeptide binding]; other site 336982002242 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 336982002243 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: MtLigD_Pol_like; cd04863 336982002244 nucleotide binding site [chemical binding]; other site 336982002245 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 336982002246 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 336982002247 active site 336982002248 DNA binding site [nucleotide binding] 336982002249 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 336982002250 DNA binding site [nucleotide binding] 336982002251 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 336982002252 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 336982002253 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982002254 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982002255 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 336982002256 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 336982002257 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982002258 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 336982002259 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 336982002260 short chain dehydrogenase; Provisional; Region: PRK08251 336982002261 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 336982002262 putative NAD(P) binding site [chemical binding]; other site 336982002263 active site 336982002264 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 336982002265 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 336982002266 active site 336982002267 dimer interface [polypeptide binding]; other site 336982002268 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 336982002269 dimer interface [polypeptide binding]; other site 336982002270 active site 336982002271 Predicted esterase [General function prediction only]; Region: COG0627 336982002272 Chorismate mutase type II; Region: CM_2; cl00693 336982002273 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 336982002274 UvrD/REP helicase; Region: UvrD-helicase; cl14126 336982002275 Peptidase family M23; Region: Peptidase_M23; pfam01551 336982002276 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 336982002277 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 336982002278 CoA-ligase; Region: Ligase_CoA; pfam00549 336982002279 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 336982002280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982002281 CoA-ligase; Region: Ligase_CoA; pfam00549 336982002282 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 336982002283 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982002284 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Region: PurN; TIGR00639 336982002285 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 336982002286 active site 336982002287 substrate binding site [chemical binding]; other site 336982002288 cosubstrate binding site; other site 336982002289 catalytic site [active] 336982002290 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 336982002291 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 336982002292 purine monophosphate binding site [chemical binding]; other site 336982002293 dimer interface [polypeptide binding]; other site 336982002294 putative catalytic residues [active] 336982002295 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 336982002296 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 336982002297 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 336982002298 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982002299 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 336982002300 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 336982002301 homotetrameric interface [polypeptide binding]; other site 336982002302 putative active site [active] 336982002303 metal binding site [ion binding]; metal-binding site 336982002304 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 336982002305 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 336982002306 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 336982002307 putative homotetramer interface [polypeptide binding]; other site 336982002308 putative homodimer interface [polypeptide binding]; other site 336982002309 allosteric switch controlling residues; other site 336982002310 putative metal binding site [ion binding]; other site 336982002311 putative homodimer-homodimer interface [polypeptide binding]; other site 336982002312 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 336982002313 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 336982002314 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982002315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982002316 enoyl-CoA hydratase; Provisional; Region: PRK07827 336982002317 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982002318 substrate binding site [chemical binding]; other site 336982002319 oxyanion hole (OAH) forming residues; other site 336982002320 trimer interface [polypeptide binding]; other site 336982002321 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982002322 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 336982002323 active site 336982002324 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 336982002325 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 336982002326 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 336982002327 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 336982002328 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 336982002329 carboxyltransferase (CT) interaction site; other site 336982002330 biotinylation site [posttranslational modification]; other site 336982002331 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 336982002332 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 336982002333 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 336982002334 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982002335 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982002336 active site 336982002337 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 336982002338 PE family; Region: PE; pfam00934 336982002339 PE family; Region: PE; pfam00934 336982002340 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 336982002341 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 336982002342 PE family; Region: PE; pfam00934 336982002343 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 336982002344 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 336982002345 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 336982002346 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982002347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 336982002348 active site 336982002349 phosphorylation site [posttranslational modification] 336982002350 intermolecular recognition site; other site 336982002351 dimerization interface [polypeptide binding]; other site 336982002352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 336982002353 DNA binding site [nucleotide binding] 336982002354 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 336982002355 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 336982002356 dimerization interface [polypeptide binding]; other site 336982002357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 336982002358 dimer interface [polypeptide binding]; other site 336982002359 phosphorylation site [posttranslational modification] 336982002360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982002361 ATP binding site [chemical binding]; other site 336982002362 Mg2+ binding site [ion binding]; other site 336982002363 G-X-G motif; other site 336982002364 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 336982002365 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 336982002366 MPT binding site; other site 336982002367 trimer interface [polypeptide binding]; other site 336982002368 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 336982002369 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 336982002370 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 336982002371 Walker A/P-loop; other site 336982002372 ATP binding site [chemical binding]; other site 336982002373 Q-loop/lid; other site 336982002374 ABC transporter signature motif; other site 336982002375 Walker B; other site 336982002376 D-loop; other site 336982002377 H-loop/switch region; other site 336982002378 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 336982002379 FtsX-like permease family; Region: FtsX; pfam02687 336982002380 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 336982002381 FtsX-like permease family; Region: FtsX; pfam02687 336982002382 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 336982002383 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 336982002384 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 336982002385 substrate binding pocket [chemical binding]; other site 336982002386 chain length determination region; other site 336982002387 substrate-Mg2+ binding site; other site 336982002388 catalytic residues [active] 336982002389 aspartate-rich region 1; other site 336982002390 active site lid residues [active] 336982002391 aspartate-rich region 2; other site 336982002392 SAF domain; Region: SAF; cl00555 336982002393 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 336982002394 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 336982002395 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982002396 active site 336982002397 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 336982002398 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 336982002399 dimer interface [polypeptide binding]; other site 336982002400 putative functional site; other site 336982002401 putative MPT binding site; other site 336982002402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 336982002403 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 336982002404 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982002405 ligand binding site [chemical binding]; other site 336982002406 flexible hinge region; other site 336982002407 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 336982002408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982002409 Coenzyme A binding pocket [chemical binding]; other site 336982002410 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 336982002411 Amidinotransferase; Region: Amidinotransf; cl12043 336982002412 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 336982002413 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 336982002414 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 336982002415 Predicted methyltransferases [General function prediction only]; Region: COG0313 336982002416 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 336982002417 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 336982002418 chorismate binding enzyme; Region: Chorismate_bind; cl10555 336982002419 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 336982002420 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 336982002421 active site 336982002422 HIGH motif; other site 336982002423 KMSKS motif; other site 336982002424 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 336982002425 tRNA binding surface [nucleotide binding]; other site 336982002426 anticodon binding site; other site 336982002427 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 336982002428 active site 336982002429 Domain of unknown function (DUF348); Region: DUF348; pfam03990 336982002430 Domain of unknown function (DUF348); Region: DUF348; pfam03990 336982002431 G5 domain; Region: G5; pfam07501 336982002432 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 336982002433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982002434 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 336982002435 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 336982002436 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 336982002437 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982002438 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982002439 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982002440 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 336982002441 putative active site [active] 336982002442 catalytic residue [active] 336982002443 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 336982002444 5S rRNA interface [nucleotide binding]; other site 336982002445 CTC domain interface; other site 336982002446 L16 interface [polypeptide binding]; other site 336982002447 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 336982002448 ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251 336982002449 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 336982002450 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 336982002451 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 336982002452 Substrate binding site [chemical binding]; other site 336982002453 Mg++ binding site [ion binding]; other site 336982002454 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 336982002455 active site 336982002456 substrate binding site [chemical binding]; other site 336982002457 CoA binding site [chemical binding]; other site 336982002458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982002459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982002460 transcription-repair coupling factor; Provisional; Region: PRK10689 336982002461 transcription-repair coupling factor; Region: mfd; TIGR00580 336982002462 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 336982002463 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982002464 ATP binding site [chemical binding]; other site 336982002465 putative Mg++ binding site [ion binding]; other site 336982002466 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982002467 nucleotide binding region [chemical binding]; other site 336982002468 ATP-binding site [chemical binding]; other site 336982002469 TRCF domain; Region: TRCF; pfam03461 336982002470 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 336982002471 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 336982002472 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 336982002473 N-acetyl-D-glucosamine binding site [chemical binding]; other site 336982002474 enolase; Provisional; Region: eno; PRK00077 336982002475 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 336982002476 dimer interface [polypeptide binding]; other site 336982002477 metal binding site [ion binding]; metal-binding site 336982002478 substrate binding pocket [chemical binding]; other site 336982002479 Septum formation initiator; Region: DivIC; cl11433 336982002480 Protein of unknown function (DUF501); Region: DUF501; cl00652 336982002481 exopolyphosphatase; Region: exo_poly_only; TIGR03706 336982002482 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 336982002483 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 336982002484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 336982002485 active site 336982002486 phosphorylation site [posttranslational modification] 336982002487 intermolecular recognition site; other site 336982002488 dimerization interface [polypeptide binding]; other site 336982002489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 336982002490 DNA binding site [nucleotide binding] 336982002491 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 336982002492 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 336982002493 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 336982002494 Ligand Binding Site [chemical binding]; other site 336982002495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 336982002496 dimer interface [polypeptide binding]; other site 336982002497 phosphorylation site [posttranslational modification] 336982002498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982002499 ATP binding site [chemical binding]; other site 336982002500 Mg2+ binding site [ion binding]; other site 336982002501 G-X-G motif; other site 336982002502 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 336982002503 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 336982002504 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 336982002505 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982002506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982002507 K+-transporting ATPase, c chain; Region: KdpC; cl00944 336982002508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 336982002509 dimer interface [polypeptide binding]; other site 336982002510 phosphorylation site [posttranslational modification] 336982002511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982002512 ATP binding site [chemical binding]; other site 336982002513 Mg2+ binding site [ion binding]; other site 336982002514 G-X-G motif; other site 336982002515 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982002516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 336982002517 active site 336982002518 phosphorylation site [posttranslational modification] 336982002519 intermolecular recognition site; other site 336982002520 dimerization interface [polypeptide binding]; other site 336982002521 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 336982002522 DNA binding site [nucleotide binding] 336982002523 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 336982002524 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 336982002525 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982002526 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982002527 PPE family; Region: PPE; pfam00823 336982002528 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982002529 PE family; Region: PE; pfam00934 336982002530 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982002531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 336982002532 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 336982002533 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 336982002534 Predicted transcriptional regulator [Transcription]; Region: COG5340 336982002535 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 336982002536 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982002537 MULE transposase domain; Region: MULE; pfam10551 336982002538 Transcriptional regulators [Transcription]; Region: MarR; COG1846 336982002539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982002540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982002541 NAD(P) binding site [chemical binding]; other site 336982002542 active site 336982002543 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 336982002544 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 336982002545 Domain of unknown function (DUF427); Region: DUF427; cl00998 336982002546 D-lactate dehydrogenase; Provisional; Region: PRK11183 336982002547 Domain of unknown function (DUF427); Region: DUF427; cl00998 336982002548 Uncharacterized conserved protein [Function unknown]; Region: COG3391 336982002549 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982002550 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 336982002551 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 336982002552 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 336982002553 hydrophobic ligand binding site; other site 336982002554 TIGR03442 family protein; Region: TIGR03442 336982002555 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 336982002556 putative active site [active] 336982002557 putative dimer interface [polypeptide binding]; other site 336982002558 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 336982002559 nucleophile elbow; other site 336982002560 hypothetical protein; Provisional; Region: PRK10279 336982002561 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 336982002562 active site 336982002563 nucleophile elbow; other site 336982002564 Cysteine dioxygenase type I; Region: CDO_I; cl02350 336982002565 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 336982002566 active site residue [active] 336982002567 PE family; Region: PE; pfam00934 336982002568 PE family; Region: PE; pfam00934 336982002569 Predicted membrane protein [Function unknown]; Region: COG4425 336982002570 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 336982002571 enoyl-CoA hydratase; Provisional; Region: PRK05862 336982002572 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982002573 substrate binding site [chemical binding]; other site 336982002574 oxyanion hole (OAH) forming residues; other site 336982002575 trimer interface [polypeptide binding]; other site 336982002576 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 336982002577 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982002578 substrate binding site [chemical binding]; other site 336982002579 oxyanion hole (OAH) forming residues; other site 336982002580 trimer interface [polypeptide binding]; other site 336982002581 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473 336982002582 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 336982002583 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 336982002584 dimer interface [polypeptide binding]; other site 336982002585 active site 336982002586 FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it turn are loaded onto the acyl...; Region: FeeA_FeeB_like; cd01836 336982002587 active site 336982002588 catalytic triad [active] 336982002589 oxyanion hole [active] 336982002590 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 336982002591 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982002592 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 336982002593 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 336982002594 dimer interface [polypeptide binding]; other site 336982002595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982002596 catalytic residue [active] 336982002597 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as...; Region: CBS_pair_PALP_assoc2; cd04609 336982002598 RDD family; Region: RDD; cl00746 336982002599 cystathionine gamma-synthase; Provisional; Region: PRK07811 336982002600 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 336982002601 homodimer interface [polypeptide binding]; other site 336982002602 substrate-cofactor binding pocket; other site 336982002603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982002604 catalytic residue [active] 336982002605 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 336982002606 domain; Region: GreA_GreB_N; pfam03449 336982002607 C-term; Region: GreA_GreB; pfam01272 336982002608 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 336982002609 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 336982002610 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955 336982002611 catalytic residues [active] 336982002612 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 336982002613 Haemolysin-III related; Region: HlyIII; cl03831 336982002614 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 336982002615 catalytic residue [active] 336982002616 putative FPP diphosphate binding site; other site 336982002617 putative FPP binding hydrophobic cleft; other site 336982002618 dimer interface [polypeptide binding]; other site 336982002619 putative IPP diphosphate binding site; other site 336982002620 PE family; Region: PE; pfam00934 336982002621 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 336982002622 putative IPP diphosphate binding site; other site 336982002623 PE family; Region: PE; pfam00934 336982002624 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 336982002625 PE family; Region: PE; pfam00934 336982002626 pantothenate kinase; Provisional; Region: PRK05439 336982002627 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 336982002628 ATP-binding site [chemical binding]; other site 336982002629 CoA-binding site [chemical binding]; other site 336982002630 Mg2+-binding site [ion binding]; other site 336982002631 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 336982002632 dimer interface [polypeptide binding]; other site 336982002633 glycine-pyridoxal phosphate binding site [chemical binding]; other site 336982002634 active site 336982002635 folate binding site [chemical binding]; other site 336982002636 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 336982002637 dinuclear metal binding motif [ion binding]; other site 336982002638 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 336982002639 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 336982002640 putative active site [active] 336982002641 PhoH-like protein; Region: PhoH; cl12134 336982002642 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 336982002643 fumarate hydratase; Reviewed; Region: fumC; PRK00485 336982002644 Class II fumarases; Region: Fumarase_classII; cd01362 336982002645 active site 336982002646 tetramer interface [polypeptide binding]; other site 336982002647 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 336982002648 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 336982002649 putative active site [active] 336982002650 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 336982002651 Domain of unknown function DUF20; Region: UPF0118; cl00465 336982002652 PemK-like protein; Region: PemK; cl00995 336982002653 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982002654 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982002655 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982002656 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 336982002657 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 336982002658 putative NAD(P) binding site [chemical binding]; other site 336982002659 active site 336982002660 putative substrate binding site [chemical binding]; other site 336982002661 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 336982002662 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 336982002663 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 336982002664 generic binding surface II; other site 336982002665 generic binding surface I; other site 336982002666 LytB protein; Region: LYTB; cl00507 336982002667 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 336982002668 GTP-binding protein YchF; Reviewed; Region: PRK09601 336982002669 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 336982002670 G1 box; other site 336982002671 GTP/Mg2+ binding site [chemical binding]; other site 336982002672 Switch I region; other site 336982002673 G2 box; other site 336982002674 Switch II region; other site 336982002675 G3 box; other site 336982002676 G4 box; other site 336982002677 G5 box; other site 336982002678 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 336982002679 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 336982002680 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982002681 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 336982002682 cyclase homology domain; Region: CHD; cd07302 336982002683 nucleotidyl binding site; other site 336982002684 metal binding site [ion binding]; metal-binding site 336982002685 dimer interface [polypeptide binding]; other site 336982002686 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 336982002687 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 336982002688 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 336982002689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982002690 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 336982002691 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982002692 short chain dehydrogenase; Validated; Region: PRK05855 336982002693 Condensation domain; Region: Condensation; cl09290 336982002694 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982002695 pyruvate phosphate dikinase; Provisional; Region: PRK05878 336982002696 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 336982002697 Domain of unknown function DUF222; Region: DUF222; pfam02720 336982002698 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982002699 active site 336982002700 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 336982002701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982002702 non-specific DNA binding site [nucleotide binding]; other site 336982002703 salt bridge; other site 336982002704 sequence-specific DNA binding site [nucleotide binding]; other site 336982002705 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 336982002706 Domain of unknown function (DUF955); Region: DUF955; cl01076 336982002707 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 336982002708 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 336982002709 citrate synthase; Provisional; Region: PRK14033 336982002710 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 336982002711 oxalacetate binding site [chemical binding]; other site 336982002712 citrylCoA binding site [chemical binding]; other site 336982002713 coenzyme A binding site [chemical binding]; other site 336982002714 catalytic triad [active] 336982002715 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 336982002716 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 336982002717 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 336982002718 THF binding site; other site 336982002719 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 336982002720 substrate binding site [chemical binding]; other site 336982002721 THF binding site; other site 336982002722 zinc-binding site [ion binding]; other site 336982002723 PPE family; Region: PPE; pfam00823 336982002724 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 336982002725 active site 336982002726 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982002727 substrate binding site [chemical binding]; other site 336982002728 oxyanion hole (OAH) forming residues; other site 336982002729 enoyl-CoA hydratase; Provisional; Region: PRK06494 336982002730 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 336982002731 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 336982002732 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 336982002733 enoyl-CoA hydratase; Provisional; Region: PRK06688 336982002734 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 336982002735 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982002736 trimer interface [polypeptide binding]; other site 336982002737 enoyl-CoA hydratase; Provisional; Region: PRK06688 336982002738 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982002739 substrate binding site [chemical binding]; other site 336982002740 oxyanion hole (OAH) forming residues; other site 336982002741 trimer interface [polypeptide binding]; other site 336982002742 CoA-transferase family III; Region: CoA_transf_3; cl00778 336982002743 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 336982002744 NAD binding site [chemical binding]; other site 336982002745 homotetramer interface [polypeptide binding]; other site 336982002746 homodimer interface [polypeptide binding]; other site 336982002747 active site 336982002748 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982002749 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982002750 Domain of unknown function DUF222; Region: DUF222; pfam02720 336982002751 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982002752 active site 336982002753 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 336982002754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 336982002755 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412 336982002756 NAD+ binding site [chemical binding]; other site 336982002757 substrate binding site [chemical binding]; other site 336982002758 Zn binding site [ion binding]; other site 336982002759 Predicted transcriptional regulators [Transcription]; Region: COG1725 336982002760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982002761 DNA-binding site [nucleotide binding]; DNA binding site 336982002762 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982002763 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 336982002764 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 336982002765 uncharacterized HhH-GPD family protein; Region: TIGR03252 336982002766 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 336982002767 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 336982002768 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 336982002769 aromatic arch; other site 336982002770 DCoH dimer interaction site [polypeptide binding]; other site 336982002771 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 336982002772 DCoH tetramer interaction site [polypeptide binding]; other site 336982002773 substrate binding site [chemical binding]; other site 336982002774 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 336982002775 active site 336982002776 8-oxo-dGMP binding site [chemical binding]; other site 336982002777 nudix motif; other site 336982002778 metal binding site [ion binding]; metal-binding site 336982002779 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 336982002780 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_Nitrate-R-NarG-like; cd02750 336982002781 [4Fe-4S] binding site [ion binding]; other site 336982002782 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 336982002783 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 336982002784 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 336982002785 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 336982002786 molybdopterin cofactor binding site; other site 336982002787 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 336982002788 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 336982002789 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 336982002790 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 336982002791 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 336982002792 G1 box; other site 336982002793 putative GEF interaction site [polypeptide binding]; other site 336982002794 GTP/Mg2+ binding site [chemical binding]; other site 336982002795 Switch I region; other site 336982002796 G2 box; other site 336982002797 G3 box; other site 336982002798 Switch II region; other site 336982002799 G4 box; other site 336982002800 G5 box; other site 336982002801 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 336982002802 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 336982002803 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 336982002804 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 336982002805 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982002806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982002807 PPE family; Region: PPE; pfam00823 336982002808 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982002809 PE family; Region: PE; pfam00934 336982002810 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 336982002811 PE family; Region: PE; pfam00934 336982002812 FO synthase; Reviewed; Region: fbiC; PRK09234 336982002813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 336982002814 FeS/SAM binding site; other site 336982002815 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 336982002816 FeS/SAM binding site; other site 336982002817 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 336982002818 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 336982002819 active site 336982002820 FMN binding site [chemical binding]; other site 336982002821 2,4-decadienoyl-CoA binding site; other site 336982002822 catalytic residue [active] 336982002823 4Fe-4S cluster binding site [ion binding]; other site 336982002824 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 336982002825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982002826 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 336982002827 Ferredoxin [Energy production and conversion]; Region: COG1146 336982002828 4Fe-4S binding domain; Region: Fer4; cl02805 336982002829 aspartate aminotransferase; Provisional; Region: PRK07681 336982002830 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982002831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982002832 homodimer interface [polypeptide binding]; other site 336982002833 catalytic residue [active] 336982002834 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 336982002835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 336982002836 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 336982002837 ATP binding site [chemical binding]; other site 336982002838 putative Mg++ binding site [ion binding]; other site 336982002839 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 336982002840 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982002841 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982002842 active site 336982002843 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982002844 PKS_DH; Region: PKS_DH; smart00826 336982002845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982002846 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982002847 Enoylreductase; Region: PKS_ER; smart00829 336982002848 NAD(P) binding site [chemical binding]; other site 336982002849 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 336982002850 putative NADP binding site [chemical binding]; other site 336982002851 active site 336982002852 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982002853 Condensation domain; Region: Condensation; cl09290 336982002854 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982002855 PE-PPE domain; Region: PE-PPE; pfam08237 336982002856 acyl-CoA synthetase; Validated; Region: PRK05850 336982002857 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982002858 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982002859 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982002860 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 336982002861 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 336982002862 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982002863 Glutamate binding site [chemical binding]; other site 336982002864 NAD binding site [chemical binding]; other site 336982002865 catalytic residues [active] 336982002866 Proline dehydrogenase; Region: Pro_dh; cl03282 336982002867 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 336982002868 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982002869 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 336982002870 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982002871 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982002872 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982002873 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982002874 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982002875 acyl-CoA synthetase; Validated; Region: PRK07787 336982002876 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982002877 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 336982002878 PE family; Region: PE; pfam00934 336982002879 PPE family; Region: PPE; pfam00823 336982002880 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982002881 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982002882 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982002883 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982002884 MULE transposase domain; Region: MULE; pfam10551 336982002885 metabolite-proton symporter; Region: 2A0106; TIGR00883 336982002886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982002887 putative substrate translocation pore; other site 336982002888 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 336982002889 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 336982002890 putative trimer interface [polypeptide binding]; other site 336982002891 putative CoA binding site [chemical binding]; other site 336982002892 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 336982002893 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 336982002894 metal binding site [ion binding]; metal-binding site 336982002895 putative dimer interface [polypeptide binding]; other site 336982002896 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 336982002897 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 336982002898 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 336982002899 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982002900 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 336982002901 dihydropteroate synthase; Region: DHPS; TIGR01496 336982002902 substrate binding pocket [chemical binding]; other site 336982002903 dimer interface [polypeptide binding]; other site 336982002904 inhibitor binding site; inhibition site 336982002905 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982002906 active site 336982002907 DivIVA domain; Region: DivI1A_domain; TIGR03544 336982002908 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 336982002909 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 336982002910 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 336982002911 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 336982002912 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 336982002913 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 336982002914 ligand binding site [chemical binding]; other site 336982002915 oligomer interface [polypeptide binding]; other site 336982002916 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 336982002917 dimer interface [polypeptide binding]; other site 336982002918 N-terminal domain interface [polypeptide binding]; other site 336982002919 sulfate 1 binding site; other site 336982002920 PE family; Region: PE; pfam00934 336982002921 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 336982002922 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 336982002923 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 336982002924 ABC-2 type transporter; Region: ABC2_membrane; cl11417 336982002925 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 336982002926 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 336982002927 Walker A/P-loop; other site 336982002928 ATP binding site [chemical binding]; other site 336982002929 Q-loop/lid; other site 336982002930 ABC transporter signature motif; other site 336982002931 Walker B; other site 336982002932 D-loop; other site 336982002933 H-loop/switch region; other site 336982002934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982002935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982002936 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 336982002937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982002938 S-adenosylmethionine binding site [chemical binding]; other site 336982002939 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 336982002940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982002941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 336982002942 DNA binding residues [nucleotide binding] 336982002943 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 336982002944 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 336982002945 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 336982002946 protein binding site [polypeptide binding]; other site 336982002947 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 336982002948 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 336982002949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 336982002950 active site 336982002951 motif I; other site 336982002952 motif II; other site 336982002953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 336982002954 Predicted membrane protein [Function unknown]; Region: COG3428 336982002955 Bacterial membrane flanked domain; Region: DUF304; cl01348 336982002956 Bacterial membrane flanked domain; Region: DUF304; cl01348 336982002957 Phd_YefM; Region: PhdYeFM; cl09153 336982002958 Domain of unknown function DUF59; Region: DUF59; cl00941 336982002959 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 336982002960 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 336982002961 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 336982002962 N-acetyl-D-glucosamine binding site [chemical binding]; other site 336982002963 catalytic residue [active] 336982002964 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 336982002965 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 336982002966 MgtE intracellular N domain; Region: MgtE_N; cl15244 336982002967 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 336982002968 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 336982002969 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982002970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982002971 dimer interface [polypeptide binding]; other site 336982002972 conserved gate region; other site 336982002973 putative PBP binding loops; other site 336982002974 ABC-ATPase subunit interface; other site 336982002975 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 336982002976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982002977 dimer interface [polypeptide binding]; other site 336982002978 conserved gate region; other site 336982002979 ABC-ATPase subunit interface; other site 336982002980 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 336982002981 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 336982002982 Walker A/P-loop; other site 336982002983 ATP binding site [chemical binding]; other site 336982002984 Q-loop/lid; other site 336982002985 ABC transporter signature motif; other site 336982002986 Walker B; other site 336982002987 D-loop; other site 336982002988 H-loop/switch region; other site 336982002989 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 336982002990 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 336982002991 malate dehydrogenase; Provisional; Region: PRK05442 336982002992 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 336982002993 NAD(P) binding site [chemical binding]; other site 336982002994 dimer interface [polypeptide binding]; other site 336982002995 malate binding site [chemical binding]; other site 336982002996 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982002997 PE family; Region: PE; pfam00934 336982002998 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982002999 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 336982003000 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 336982003001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982003002 NAD(P) binding site [chemical binding]; other site 336982003003 active site 336982003004 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 336982003005 Phd_YefM; Region: PhdYeFM; cl09153 336982003006 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 336982003007 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 336982003008 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 336982003009 TPP-binding site [chemical binding]; other site 336982003010 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 336982003011 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 336982003012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982003013 putative substrate translocation pore; other site 336982003014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982003015 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 336982003016 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 336982003017 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 336982003018 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 336982003019 ATP binding site [chemical binding]; other site 336982003020 Mg++ binding site [ion binding]; other site 336982003021 motif III; other site 336982003022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982003023 nucleotide binding region [chemical binding]; other site 336982003024 ATP-binding site [chemical binding]; other site 336982003025 DbpA RNA binding domain; Region: DbpA; pfam03880 336982003026 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 336982003027 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 336982003028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982003029 Cytochrome P450; Region: p450; cl12078 336982003030 FAD binding domain; Region: FAD_binding_4; pfam01565 336982003031 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 336982003032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982003033 H+ Antiporter protein; Region: 2A0121; TIGR00900 336982003034 putative substrate translocation pore; other site 336982003035 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 336982003036 hypothetical protein; Validated; Region: PRK05868 336982003037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982003038 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982003039 Domain of unknown function (DUF385); Region: DUF385; cl04387 336982003040 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 336982003041 HIT family signature motif; other site 336982003042 catalytic residue [active] 336982003043 amidase; Provisional; Region: PRK12470 336982003044 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 336982003045 cyclase homology domain; Region: CHD; cd07302 336982003046 nucleotidyl binding site; other site 336982003047 metal binding site [ion binding]; metal-binding site 336982003048 dimer interface [polypeptide binding]; other site 336982003049 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982003050 active site 336982003051 ATP binding site [chemical binding]; other site 336982003052 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982003053 substrate binding site [chemical binding]; other site 336982003054 activation loop (A-loop); other site 336982003055 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 336982003056 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 336982003057 DNA binding site [nucleotide binding] 336982003058 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 336982003059 phosphopeptide binding site; other site 336982003060 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 336982003061 putative active site [active] 336982003062 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 336982003063 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982003064 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 336982003065 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 336982003066 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 336982003067 Walker A/P-loop; other site 336982003068 ATP binding site [chemical binding]; other site 336982003069 Q-loop/lid; other site 336982003070 ABC transporter signature motif; other site 336982003071 Walker B; other site 336982003072 D-loop; other site 336982003073 H-loop/switch region; other site 336982003074 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 336982003075 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 336982003076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982003077 Walker A/P-loop; other site 336982003078 ATP binding site [chemical binding]; other site 336982003079 Q-loop/lid; other site 336982003080 ABC transporter signature motif; other site 336982003081 Walker B; other site 336982003082 D-loop; other site 336982003083 H-loop/switch region; other site 336982003084 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 336982003085 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 336982003086 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982003087 catalytic core [active] 336982003088 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 336982003089 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 336982003090 active site 336982003091 metal binding site [ion binding]; metal-binding site 336982003092 DNA binding site [nucleotide binding] 336982003093 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982003094 Uncharacterized conserved protein [Function unknown]; Region: COG4717 336982003095 choline dehydrogenase; Validated; Region: PRK02106 336982003096 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 336982003097 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 336982003098 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 336982003099 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 336982003100 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 336982003101 Walker A/P-loop; other site 336982003102 ATP binding site [chemical binding]; other site 336982003103 Q-loop/lid; other site 336982003104 ABC transporter signature motif; other site 336982003105 Walker B; other site 336982003106 D-loop; other site 336982003107 H-loop/switch region; other site 336982003108 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 336982003109 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 336982003110 Walker A/P-loop; other site 336982003111 ATP binding site [chemical binding]; other site 336982003112 Q-loop/lid; other site 336982003113 ABC transporter signature motif; other site 336982003114 Walker B; other site 336982003115 D-loop; other site 336982003116 H-loop/switch region; other site 336982003117 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 336982003118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982003119 dimer interface [polypeptide binding]; other site 336982003120 conserved gate region; other site 336982003121 putative PBP binding loops; other site 336982003122 ABC-ATPase subunit interface; other site 336982003123 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 336982003124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982003125 dimer interface [polypeptide binding]; other site 336982003126 conserved gate region; other site 336982003127 putative PBP binding loops; other site 336982003128 ABC-ATPase subunit interface; other site 336982003129 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 336982003130 active site clefts [active] 336982003131 zinc binding site [ion binding]; other site 336982003132 dimer interface [polypeptide binding]; other site 336982003133 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 336982003134 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 336982003135 Active Sites [active] 336982003136 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 336982003137 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 336982003138 CysD dimerization site [polypeptide binding]; other site 336982003139 G1 box; other site 336982003140 putative GEF interaction site [polypeptide binding]; other site 336982003141 GTP/Mg2+ binding site [chemical binding]; other site 336982003142 Switch I region; other site 336982003143 G2 box; other site 336982003144 G3 box; other site 336982003145 Switch II region; other site 336982003146 G4 box; other site 336982003147 G5 box; other site 336982003148 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 336982003149 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 336982003150 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 336982003151 ligand-binding site [chemical binding]; other site 336982003152 Rrf2 family protein; Region: rrf2_super; TIGR00738 336982003153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982003154 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 336982003155 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 336982003156 putative peptidoglycan binding site; other site 336982003157 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 336982003158 putative peptidoglycan binding site; other site 336982003159 Putative esterase; Region: Esterase; pfam00756 336982003160 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982003161 Predicted membrane protein [Function unknown]; Region: COG4325 336982003162 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982003163 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 336982003164 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 336982003165 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 336982003166 active site 336982003167 HIGH motif; other site 336982003168 KMSK motif region; other site 336982003169 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 336982003170 tRNA binding surface [nucleotide binding]; other site 336982003171 anticodon binding site; other site 336982003172 diaminopimelate decarboxylase; Region: lysA; TIGR01048 336982003173 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 336982003174 active site 336982003175 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 336982003176 substrate binding site [chemical binding]; other site 336982003177 catalytic residues [active] 336982003178 dimer interface [polypeptide binding]; other site 336982003179 homoserine dehydrogenase; Provisional; Region: PRK06349 336982003180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982003181 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 336982003182 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 336982003183 threonine synthase; Reviewed; Region: PRK06721 336982003184 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 336982003185 homodimer interface [polypeptide binding]; other site 336982003186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982003187 catalytic residue [active] 336982003188 homoserine kinase; Provisional; Region: PRK01212 336982003189 transcription termination factor Rho; Provisional; Region: PRK12678 336982003190 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 336982003191 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 336982003192 RNA binding site [nucleotide binding]; other site 336982003193 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 336982003194 multimer interface [polypeptide binding]; other site 336982003195 Walker A motif; other site 336982003196 ATP binding site [chemical binding]; other site 336982003197 Walker B motif; other site 336982003198 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 336982003199 peptide chain release factor 1; Region: prfA; TIGR00019 336982003200 RF-1 domain; Region: RF-1; cl02875 336982003201 RF-1 domain; Region: RF-1; cl02875 336982003202 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 336982003203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982003204 S-adenosylmethionine binding site [chemical binding]; other site 336982003205 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 336982003206 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 336982003207 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 336982003208 Mg++ binding site [ion binding]; other site 336982003209 putative catalytic motif [active] 336982003210 substrate binding site [chemical binding]; other site 336982003211 ATP synthase A chain; Region: ATP-synt_A; cl00413 336982003212 ATP synthase subunit C; Region: ATP-synt_C; cl00466 336982003213 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 336982003214 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 336982003215 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 336982003216 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 336982003217 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 336982003218 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 336982003219 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982003220 Walker A motif; other site 336982003221 ATP binding site [chemical binding]; other site 336982003222 Walker B motif; other site 336982003223 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 336982003224 ATP synthase; Region: ATP-synt; cl00365 336982003225 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 336982003226 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 336982003227 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 336982003228 alpha subunit interaction interface [polypeptide binding]; other site 336982003229 Walker A motif; other site 336982003230 ATP binding site [chemical binding]; other site 336982003231 Walker B motif; other site 336982003232 inhibitor binding site; inhibition site 336982003233 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 336982003234 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 336982003235 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 336982003236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 336982003237 Transposase; Region: DDE_Tnp_ISL3; pfam01610 336982003238 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 336982003239 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 336982003240 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 336982003241 hinge; other site 336982003242 active site 336982003243 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 336982003244 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 336982003245 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 336982003246 DNA binding site [nucleotide binding] 336982003247 active site 336982003248 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 336982003249 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 336982003250 AlkA N-terminal domain; Region: AlkA_N; pfam06029 336982003251 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 336982003252 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 336982003253 minor groove reading motif; other site 336982003254 helix-hairpin-helix signature motif; other site 336982003255 substrate binding pocket [chemical binding]; other site 336982003256 active site 336982003257 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 336982003258 cyclase homology domain; Region: CHD; cd07302 336982003259 nucleotidyl binding site; other site 336982003260 metal binding site [ion binding]; metal-binding site 336982003261 dimer interface [polypeptide binding]; other site 336982003262 cyclase homology domain; Region: CHD; cd07302 336982003263 nucleotidyl binding site; other site 336982003264 metal binding site [ion binding]; metal-binding site 336982003265 dimer interface [polypeptide binding]; other site 336982003266 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982003267 putative transposase OrfB; Reviewed; Region: PHA02517 336982003268 Integrase core domain; Region: rve; cl01316 336982003269 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 336982003270 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 336982003271 cyclase homology domain; Region: CHD; cd07302 336982003272 nucleotidyl binding site; other site 336982003273 metal binding site [ion binding]; metal-binding site 336982003274 dimer interface [polypeptide binding]; other site 336982003275 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 336982003276 cyclase homology domain; Region: CHD; cd07302 336982003277 nucleotidyl binding site; other site 336982003278 metal binding site [ion binding]; metal-binding site 336982003279 dimer interface [polypeptide binding]; other site 336982003280 Protein of unknown function DUF91; Region: DUF91; cl00709 336982003281 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 336982003282 dimer interface [polypeptide binding]; other site 336982003283 substrate binding site [chemical binding]; other site 336982003284 metal binding site [ion binding]; metal-binding site 336982003285 putative acyltransferase; Provisional; Region: PRK05790 336982003286 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 336982003287 dimer interface [polypeptide binding]; other site 336982003288 active site 336982003289 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 336982003290 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 336982003291 PE family; Region: PE; pfam00934 336982003292 glycogen branching enzyme; Provisional; Region: PRK05402 336982003293 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 336982003294 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 336982003295 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 336982003296 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 336982003297 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 336982003298 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 336982003299 putative homodimer interface [polypeptide binding]; other site 336982003300 putative active site pocket [active] 336982003301 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 336982003302 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 336982003303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 336982003304 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 336982003305 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 336982003306 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 336982003307 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 336982003308 active site 336982003309 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 336982003310 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 336982003311 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 336982003312 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 336982003313 putative active site pocket [active] 336982003314 cleavage site 336982003315 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 336982003316 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982003317 Rhomboid family; Region: Rhomboid; cl11446 336982003318 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 336982003319 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982003320 ribonuclease PH; Reviewed; Region: rph; PRK00173 336982003321 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 336982003322 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 336982003323 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 336982003324 active site 336982003325 dimerization interface [polypeptide binding]; other site 336982003326 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 336982003327 Glucitol operon activator protein (GutM); Region: GutM; cl01890 336982003328 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982003329 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 336982003330 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982003331 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982003332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982003333 active site 336982003334 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 336982003335 Siderophore biosynthesis protein domain; Region: AlcB; pfam10331 336982003336 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 336982003337 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 336982003338 FAD binding pocket [chemical binding]; other site 336982003339 FAD binding motif [chemical binding]; other site 336982003340 phosphate binding motif [ion binding]; other site 336982003341 NAD binding pocket [chemical binding]; other site 336982003342 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 336982003343 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982003344 Walker A/P-loop; other site 336982003345 ATP binding site [chemical binding]; other site 336982003346 Q-loop/lid; other site 336982003347 ABC transporter signature motif; other site 336982003348 Walker B; other site 336982003349 D-loop; other site 336982003350 H-loop/switch region; other site 336982003351 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 336982003352 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982003353 Walker A/P-loop; other site 336982003354 ATP binding site [chemical binding]; other site 336982003355 Q-loop/lid; other site 336982003356 ABC transporter signature motif; other site 336982003357 Walker B; other site 336982003358 D-loop; other site 336982003359 H-loop/switch region; other site 336982003360 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 336982003361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982003362 NAD(P) binding site [chemical binding]; other site 336982003363 active site 336982003364 tetracycline repressor protein TetR; Provisional; Region: PRK13756 336982003365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982003366 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 336982003367 GAF domain; Region: GAF; cl00853 336982003368 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 336982003369 metal binding site [ion binding]; metal-binding site 336982003370 active site 336982003371 I-site; other site 336982003372 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 336982003373 hypothetical protein; Provisional; Region: PRK07877 336982003374 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 336982003375 ATP binding site [chemical binding]; other site 336982003376 substrate interface [chemical binding]; other site 336982003377 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 336982003378 cyclase homology domain; Region: CHD; cd07302 336982003379 nucleotidyl binding site; other site 336982003380 dimer interface [polypeptide binding]; other site 336982003381 metal binding site [ion binding]; metal-binding site 336982003382 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982003383 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 336982003384 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 336982003385 DNA binding residues [nucleotide binding] 336982003386 dimerization interface [polypeptide binding]; other site 336982003387 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 336982003388 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 336982003389 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982003390 PPE family; Region: PPE; pfam00823 336982003391 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982003392 PAS fold; Region: PAS_4; pfam08448 336982003393 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 336982003394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 336982003395 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 336982003396 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 336982003397 anti sigma factor interaction site; other site 336982003398 regulatory phosphorylation site [posttranslational modification]; other site 336982003399 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 336982003400 synthetase active site [active] 336982003401 NTP binding site [chemical binding]; other site 336982003402 metal binding site [ion binding]; metal-binding site 336982003403 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982003404 Beta-lactamase; Region: Beta-lactamase; cl01009 336982003405 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 336982003406 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 336982003407 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 336982003408 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 336982003409 putative di-iron ligands [ion binding]; other site 336982003410 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 336982003411 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 336982003412 malonyl-CoA binding site [chemical binding]; other site 336982003413 dimer interface [polypeptide binding]; other site 336982003414 active site 336982003415 product binding site; other site 336982003416 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 336982003417 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 336982003418 YcaO-like family; Region: YcaO; cl09146 336982003419 Uncharacterized conserved protein [Function unknown]; Region: COG3482 336982003420 TfuA-like protein; Region: TfuA; pfam07812 336982003421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982003422 S-adenosylmethionine binding site [chemical binding]; other site 336982003423 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 336982003424 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 336982003425 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 336982003426 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 336982003427 dihydroorotase; Validated; Region: pyrC; PRK09357 336982003428 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 336982003429 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 336982003430 active site 336982003431 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 336982003432 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 336982003433 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 336982003434 catalytic site [active] 336982003435 subunit interface [polypeptide binding]; other site 336982003436 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 336982003437 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 336982003438 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 336982003439 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 336982003440 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 336982003441 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 336982003442 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 336982003443 IMP binding site; other site 336982003444 dimer interface [polypeptide binding]; other site 336982003445 interdomain contacts; other site 336982003446 partial ornithine binding site; other site 336982003447 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 336982003448 active site 336982003449 dimer interface [polypeptide binding]; other site 336982003450 PPE family; Region: PPE; pfam00823 336982003451 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 336982003452 catalytic site [active] 336982003453 G-X2-G-X-G-K; other site 336982003454 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 336982003455 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 336982003456 Flavoprotein; Region: Flavoprotein; cl08021 336982003457 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 336982003458 S-adenosylmethionine synthetase; Validated; Region: PRK05250 336982003459 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 336982003460 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 336982003461 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 336982003462 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982003463 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982003464 Cytochrome P450; Region: p450; cl12078 336982003465 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 336982003466 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 336982003467 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 336982003468 PE family; Region: PE; pfam00934 336982003469 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 336982003470 oligomeric interface; other site 336982003471 putative active site [active] 336982003472 homodimer interface [polypeptide binding]; other site 336982003473 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 336982003474 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982003475 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982003476 substrate binding pocket [chemical binding]; other site 336982003477 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982003478 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982003479 substrate binding pocket [chemical binding]; other site 336982003480 YhhN-like protein; Region: YhhN; cl01505 336982003481 primosome assembly protein PriA; Provisional; Region: PRK14873 336982003482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982003483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982003484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982003485 S-adenosylmethionine binding site [chemical binding]; other site 336982003486 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 336982003487 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 336982003488 putative active site [active] 336982003489 substrate binding site [chemical binding]; other site 336982003490 putative cosubstrate binding site; other site 336982003491 catalytic site [active] 336982003492 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 336982003493 substrate binding site [chemical binding]; other site 336982003494 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 336982003495 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 336982003496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982003497 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 336982003498 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 336982003499 substrate binding site [chemical binding]; other site 336982003500 hexamer interface [polypeptide binding]; other site 336982003501 metal binding site [ion binding]; metal-binding site 336982003502 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 336982003503 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 336982003504 catalytic motif [active] 336982003505 Zn binding site [ion binding]; other site 336982003506 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 336982003507 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 336982003508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982003509 putative substrate translocation pore; other site 336982003510 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 336982003511 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 336982003512 Lumazine binding domain; Region: Lum_binding; pfam00677 336982003513 Lumazine binding domain; Region: Lum_binding; pfam00677 336982003514 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 336982003515 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 336982003516 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 336982003517 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 336982003518 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 336982003519 dimerization interface [polypeptide binding]; other site 336982003520 active site 336982003521 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 336982003522 homopentamer interface [polypeptide binding]; other site 336982003523 active site 336982003524 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 336982003525 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 336982003526 putative sugar binding sites [chemical binding]; other site 336982003527 Q-X-W motif; other site 336982003528 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 336982003529 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 336982003530 UvrB/uvrC motif; Region: UVR; pfam02151 336982003531 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 336982003532 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 336982003533 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 336982003534 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 336982003535 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 336982003536 phosphate binding site [ion binding]; other site 336982003537 putative substrate binding pocket [chemical binding]; other site 336982003538 dimer interface [polypeptide binding]; other site 336982003539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 336982003540 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 336982003541 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982003542 Condensation domain; Region: Condensation; cl09290 336982003543 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982003544 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982003545 substrate binding pocket [chemical binding]; other site 336982003546 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982003547 acyl-CoA synthetase; Provisional; Region: PRK13382 336982003548 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982003549 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 336982003550 putative acyl-acceptor binding pocket; other site 336982003551 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 336982003552 PE family; Region: PE; pfam00934 336982003553 PE-PPE domain; Region: PE-PPE; pfam08237 336982003554 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 336982003555 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 336982003556 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982003557 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 336982003558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982003559 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 336982003560 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 336982003561 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 336982003562 substrate binding site [chemical binding]; other site 336982003563 hinge regions; other site 336982003564 ADP binding site [chemical binding]; other site 336982003565 catalytic site [active] 336982003566 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 336982003567 substrate binding site [chemical binding]; other site 336982003568 dimer interface [polypeptide binding]; other site 336982003569 catalytic triad [active] 336982003570 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982003571 PE family; Region: PE; pfam00934 336982003572 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 336982003573 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 336982003574 molybdopterin cofactor binding site [chemical binding]; other site 336982003575 substrate binding site [chemical binding]; other site 336982003576 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 336982003577 molybdopterin cofactor binding site; other site 336982003578 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 336982003579 hydrophobic ligand binding site; other site 336982003580 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 336982003581 putative active site [active] 336982003582 opcA protein; Region: OpcA; TIGR00534 336982003583 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 336982003584 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 336982003585 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 336982003586 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 336982003587 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 336982003588 putative active site [active] 336982003589 transaldolase; Provisional; Region: PRK03903 336982003590 catalytic residue [active] 336982003591 transketolase; Reviewed; Region: PRK05899 336982003592 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 336982003593 TPP-binding site [chemical binding]; other site 336982003594 dimer interface [polypeptide binding]; other site 336982003595 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 336982003596 PYR/PP interface [polypeptide binding]; other site 336982003597 dimer interface [polypeptide binding]; other site 336982003598 TPP binding site [chemical binding]; other site 336982003599 PE family; Region: PE; pfam00934 336982003600 UbiA prenyltransferase family; Region: UbiA; cl00337 336982003601 PE family; Region: PE; pfam00934 336982003602 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 336982003603 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 336982003604 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 336982003605 NADP binding site [chemical binding]; other site 336982003606 dimer interface [polypeptide binding]; other site 336982003607 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 336982003608 ABC-2 type transporter; Region: ABC2_membrane; cl11417 336982003609 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 336982003610 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 336982003611 Walker A/P-loop; other site 336982003612 ATP binding site [chemical binding]; other site 336982003613 Q-loop/lid; other site 336982003614 ABC transporter signature motif; other site 336982003615 Walker B; other site 336982003616 D-loop; other site 336982003617 H-loop/switch region; other site 336982003618 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 336982003619 Predicted transcriptional regulator [Transcription]; Region: COG2345 336982003620 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982003621 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 336982003622 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 336982003623 thioester formation/cholesterol transfer; other site 336982003624 protein-splicing catalytic site; other site 336982003625 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 336982003626 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 336982003627 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 336982003628 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 336982003629 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 336982003630 FeS assembly ATPase SufC; Region: sufC; TIGR01978 336982003631 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 336982003632 Walker A/P-loop; other site 336982003633 ATP binding site [chemical binding]; other site 336982003634 Q-loop/lid; other site 336982003635 ABC transporter signature motif; other site 336982003636 Walker B; other site 336982003637 D-loop; other site 336982003638 H-loop/switch region; other site 336982003639 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 336982003640 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 336982003641 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982003642 catalytic residue [active] 336982003643 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 336982003644 trimerization site [polypeptide binding]; other site 336982003645 active site 336982003646 Domain of unknown function DUF59; Region: DUF59; cl00941 336982003647 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 336982003648 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 336982003649 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982003650 active site 336982003651 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 336982003652 PE family; Region: PE; pfam00934 336982003653 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 336982003654 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982003655 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 336982003656 catalytic residues [active] 336982003657 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 336982003658 catalytic residues [active] 336982003659 enoyl-CoA hydratase; Provisional; Region: PRK05864 336982003660 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982003661 substrate binding site [chemical binding]; other site 336982003662 oxyanion hole (OAH) forming residues; other site 336982003663 trimer interface [polypeptide binding]; other site 336982003664 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 336982003665 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982003666 Walker A/P-loop; other site 336982003667 ATP binding site [chemical binding]; other site 336982003668 Q-loop/lid; other site 336982003669 ABC transporter signature motif; other site 336982003670 Walker B; other site 336982003671 D-loop; other site 336982003672 H-loop/switch region; other site 336982003673 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 336982003674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982003675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982003676 aconitate hydratase; Validated; Region: PRK09277 336982003677 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 336982003678 substrate binding site [chemical binding]; other site 336982003679 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 336982003680 ligand binding site [chemical binding]; other site 336982003681 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 336982003682 substrate binding site [chemical binding]; other site 336982003683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 336982003684 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 336982003685 NlpC/P60 family; Region: NLPC_P60; cl11438 336982003686 NlpC/P60 family; Region: NLPC_P60; cl11438 336982003687 MoxR-like ATPases [General function prediction only]; Region: COG0714 336982003688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982003689 Walker A motif; other site 336982003690 ATP binding site [chemical binding]; other site 336982003691 Walker B motif; other site 336982003692 arginine finger; other site 336982003693 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982003694 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 336982003695 Protein of unknown function DUF58; Region: DUF58; pfam01882 336982003696 hypothetical protein; Provisional; Region: PRK13685 336982003697 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 336982003698 metal ion-dependent adhesion site (MIDAS); other site 336982003699 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 336982003700 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 336982003701 NAD(P) binding site [chemical binding]; other site 336982003702 homotetramer interface [polypeptide binding]; other site 336982003703 homodimer interface [polypeptide binding]; other site 336982003704 active site 336982003705 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 336982003706 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 336982003707 NAD binding site [chemical binding]; other site 336982003708 homotetramer interface [polypeptide binding]; other site 336982003709 homodimer interface [polypeptide binding]; other site 336982003710 substrate binding site [chemical binding]; other site 336982003711 active site 336982003712 ferrochelatase; Reviewed; Region: hemH; PRK00035 336982003713 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 336982003714 C-terminal domain interface [polypeptide binding]; other site 336982003715 active site 336982003716 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 336982003717 active site 336982003718 N-terminal domain interface [polypeptide binding]; other site 336982003719 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 336982003720 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 336982003721 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 336982003722 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 336982003723 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 336982003724 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 336982003725 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 336982003726 heterodimer interface [polypeptide binding]; other site 336982003727 substrate interaction site [chemical binding]; other site 336982003728 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 336982003729 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 336982003730 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily...; Region: MM_CoA_mutase_alpha_like; cd03679 336982003731 active site 336982003732 substrate binding site [chemical binding]; other site 336982003733 coenzyme B12 binding site [chemical binding]; other site 336982003734 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 336982003735 B12 binding site [chemical binding]; other site 336982003736 cobalt ligand [ion binding]; other site 336982003737 PemK-like protein; Region: PemK; cl00995 336982003738 membrane ATPase/protein kinase; Provisional; Region: PRK09435 336982003739 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 336982003740 Walker A; other site 336982003741 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982003742 Beta-lactamase; Region: Beta-lactamase; cl01009 336982003743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982003744 S-adenosylmethionine binding site [chemical binding]; other site 336982003745 Protein of unknown function (DUF1458); Region: DUF1458; cl01328 336982003746 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 336982003747 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 336982003748 Ligand binding site [chemical binding]; other site 336982003749 Putative Catalytic site [active] 336982003750 DXD motif; other site 336982003751 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 336982003752 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 336982003753 active site 336982003754 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982003755 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 336982003756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982003757 inhibitor-cofactor binding pocket; inhibition site 336982003758 catalytic residue [active] 336982003759 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 336982003760 putative trimer interface [polypeptide binding]; other site 336982003761 putative CoA binding site [chemical binding]; other site 336982003762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982003763 WbqC-like protein family; Region: WbqC; pfam08889 336982003764 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 336982003765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982003766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982003767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982003768 GDP-mannose 4,6-dehydratase; Region: PLN02653 336982003769 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 336982003770 NADP-binding site; other site 336982003771 homotetramer interface [polypeptide binding]; other site 336982003772 substrate binding site [chemical binding]; other site 336982003773 homodimer interface [polypeptide binding]; other site 336982003774 active site 336982003775 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 336982003776 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 336982003777 NADP binding site [chemical binding]; other site 336982003778 active site 336982003779 putative substrate binding site [chemical binding]; other site 336982003780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982003781 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 336982003782 metal binding site [ion binding]; metal-binding site 336982003783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982003784 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982003785 active site 336982003786 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 336982003787 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982003788 active site 336982003789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982003790 active site 336982003791 acyl-CoA synthetase; Validated; Region: PRK05850 336982003792 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982003793 Transport protein; Region: actII; TIGR00833 336982003794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982003795 S-adenosylmethionine binding site [chemical binding]; other site 336982003796 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 336982003797 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 336982003798 homodimer interface [polypeptide binding]; other site 336982003799 active site 336982003800 TDP-binding site; other site 336982003801 acceptor substrate-binding pocket; other site 336982003802 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 336982003803 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 336982003804 Probable Catalytic site [active] 336982003805 metal binding site [ion binding]; metal-binding site 336982003806 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 336982003807 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 336982003808 homodimer interface [polypeptide binding]; other site 336982003809 active site 336982003810 TDP-binding site; other site 336982003811 acceptor substrate-binding pocket; other site 336982003812 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982003813 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982003814 active site 336982003815 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982003816 PKS_DH; Region: PKS_DH; smart00826 336982003817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982003818 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982003819 Enoylreductase; Region: PKS_ER; smart00829 336982003820 NAD(P) binding site [chemical binding]; other site 336982003821 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 336982003822 putative NADP binding site [chemical binding]; other site 336982003823 active site 336982003824 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982003825 acyl-CoA synthetase; Validated; Region: PRK05850 336982003826 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982003827 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 336982003828 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 336982003829 NAD(P) binding site [chemical binding]; other site 336982003830 Uncharacterized conserved protein [Function unknown]; Region: COG2128 336982003831 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 336982003832 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 336982003833 CoenzymeA binding site [chemical binding]; other site 336982003834 subunit interaction site [polypeptide binding]; other site 336982003835 PHB binding site; other site 336982003836 Nitronate monooxygenase; Region: NMO; pfam03060 336982003837 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 336982003838 FMN binding site [chemical binding]; other site 336982003839 substrate binding site [chemical binding]; other site 336982003840 putative catalytic residue [active] 336982003841 transcriptional regulator BetI; Validated; Region: PRK00767 336982003842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982003843 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 336982003844 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 336982003845 HIGH motif; other site 336982003846 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 336982003847 active site 336982003848 KMSKS motif; other site 336982003849 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 336982003850 tRNA binding surface [nucleotide binding]; other site 336982003851 anticodon binding site; other site 336982003852 DNA polymerase IV; Provisional; Region: PRK03348 336982003853 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 336982003854 active site 336982003855 DNA binding site [nucleotide binding] 336982003856 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 336982003857 active site/substrate binding site [active] 336982003858 tetramer interface [polypeptide binding]; other site 336982003859 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 336982003860 lipoprotein signal peptidase; Provisional; Region: PRK14787 336982003861 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 336982003862 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 336982003863 active site 336982003864 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 336982003865 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 336982003866 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 336982003867 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 336982003868 apolar tunnel; other site 336982003869 heme binding site [chemical binding]; other site 336982003870 dimerization interface [polypeptide binding]; other site 336982003871 short chain dehydrogenase; Provisional; Region: PRK05866 336982003872 classical (c) SDRs; Region: SDR_c; cd05233 336982003873 NAD(P) binding site [chemical binding]; other site 336982003874 active site 336982003875 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 336982003876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982003877 NAD(P) binding site [chemical binding]; other site 336982003878 active site 336982003879 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 336982003880 hydrophobic ligand binding site; other site 336982003881 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 336982003882 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 336982003883 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 336982003884 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 336982003885 generic binding surface II; other site 336982003886 generic binding surface I; other site 336982003887 PPE family; Region: PPE; pfam00823 336982003888 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982003889 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982003890 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982003891 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982003892 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 336982003893 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 336982003894 putative acyl-acceptor binding pocket; other site 336982003895 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 336982003896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982003897 domain; Region: Succ_DH_flav_C; pfam02910 336982003898 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 336982003899 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 336982003900 D-subunit interface [polypeptide binding]; other site 336982003901 Iron-sulfur protein interface; other site 336982003902 proximal quinone binding site [chemical binding]; other site 336982003903 distal quinone binding site [chemical binding]; other site 336982003904 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 336982003905 Iron-sulfur protein interface; other site 336982003906 proximal quinone binding site [chemical binding]; other site 336982003907 C-subunit interface; other site 336982003908 distal quinone binding site; other site 336982003909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982003910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982003911 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982003912 Domain of unknown function (DUF385); Region: DUF385; cl04387 336982003913 threonine dehydratase; Validated; Region: PRK08639 336982003914 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 336982003915 tetramer interface [polypeptide binding]; other site 336982003916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982003917 catalytic residue [active] 336982003918 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 336982003919 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 336982003920 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982003921 putative active site [active] 336982003922 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 336982003923 Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853 336982003924 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 336982003925 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 336982003926 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 336982003927 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 336982003928 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 336982003929 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 336982003930 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 336982003931 NlpC/P60 family; Region: NLPC_P60; cl11438 336982003932 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 336982003933 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 336982003934 inhibitor-cofactor binding pocket; inhibition site 336982003935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982003936 catalytic residue [active] 336982003937 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 336982003938 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982003939 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982003940 catalytic residue [active] 336982003941 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 336982003942 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 336982003943 Domain of unknown function DUF222; Region: DUF222; pfam02720 336982003944 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982003945 active site 336982003946 biotin synthase; Validated; Region: PRK06256 336982003947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 336982003948 FeS/SAM binding site; other site 336982003949 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 336982003950 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 336982003951 Secretory lipase; Region: LIP; pfam03583 336982003952 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 336982003953 nudix motif; other site 336982003954 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 336982003955 Quinolinate synthetase A protein; Region: NadA; cl00420 336982003956 L-aspartate oxidase; Provisional; Region: PRK07804 336982003957 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982003958 domain; Region: Succ_DH_flav_C; pfam02910 336982003959 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 336982003960 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 336982003961 dimerization interface [polypeptide binding]; other site 336982003962 active site 336982003963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982003964 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 336982003965 Domain of unknown function (DUF385); Region: DUF385; cl04387 336982003966 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 336982003967 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 336982003968 NAD binding site [chemical binding]; other site 336982003969 dimerization interface [polypeptide binding]; other site 336982003970 product binding site; other site 336982003971 substrate binding site [chemical binding]; other site 336982003972 zinc binding site [ion binding]; other site 336982003973 catalytic residues [active] 336982003974 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 336982003975 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982003976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982003977 homodimer interface [polypeptide binding]; other site 336982003978 catalytic residue [active] 336982003979 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 336982003980 4-fold oligomerization interface [polypeptide binding]; other site 336982003981 putative active site pocket [active] 336982003982 metal binding residues [ion binding]; metal-binding site 336982003983 3-fold/trimer interface [polypeptide binding]; other site 336982003984 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 336982003985 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 336982003986 putative active site [active] 336982003987 oxyanion strand; other site 336982003988 catalytic triad [active] 336982003989 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 336982003990 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 336982003991 catalytic residues [active] 336982003992 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 336982003993 active site 336982003994 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 336982003995 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 336982003996 substrate binding site [chemical binding]; other site 336982003997 glutamase interaction surface [polypeptide binding]; other site 336982003998 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 336982003999 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 336982004000 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 336982004001 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 336982004002 catalytic triad [active] 336982004003 anthranilate synthase component I; Provisional; Region: PRK13571 336982004004 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 336982004005 chorismate binding enzyme; Region: Chorismate_bind; cl10555 336982004006 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl09759 336982004007 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 336982004008 active site 336982004009 ribulose/triose binding site [chemical binding]; other site 336982004010 phosphate binding site [ion binding]; other site 336982004011 substrate (anthranilate) binding pocket [chemical binding]; other site 336982004012 product (indole) binding pocket [chemical binding]; other site 336982004013 tryptophan synthase, beta chain; Region: PLN02618 336982004014 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 336982004015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982004016 catalytic residue [active] 336982004017 tryptophan synthase; Region: PLN02591 336982004018 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 336982004019 substrate binding site [chemical binding]; other site 336982004020 active site 336982004021 catalytic residues [active] 336982004022 heterodimer interface [polypeptide binding]; other site 336982004023 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 336982004024 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 336982004025 TM2 domain; Region: TM2; cl00984 336982004026 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 336982004027 pyruvate kinase; Provisional; Region: PRK06247 336982004028 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 336982004029 domain interfaces; other site 336982004030 active site 336982004031 acyl-CoA thioesterase II; Region: tesB; TIGR00189 336982004032 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 336982004033 active site 336982004034 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 336982004035 catalytic triad [active] 336982004036 dimer interface [polypeptide binding]; other site 336982004037 Uncharacterized conserved protein [Function unknown]; Region: COG2898 336982004038 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 336982004039 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 336982004040 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982004041 Walker A/P-loop; other site 336982004042 ATP binding site [chemical binding]; other site 336982004043 Q-loop/lid; other site 336982004044 ABC transporter signature motif; other site 336982004045 Walker B; other site 336982004046 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 336982004047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982004048 Walker A/P-loop; other site 336982004049 ATP binding site [chemical binding]; other site 336982004050 Q-loop/lid; other site 336982004051 ABC transporter signature motif; other site 336982004052 Walker B; other site 336982004053 D-loop; other site 336982004054 H-loop/switch region; other site 336982004055 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 336982004056 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 336982004057 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 336982004058 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 336982004059 cyclase homology domain; Region: CHD; cd07302 336982004060 nucleotidyl binding site; other site 336982004061 metal binding site [ion binding]; metal-binding site 336982004062 dimer interface [polypeptide binding]; other site 336982004063 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 336982004064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 336982004065 active site 336982004066 phosphorylation site [posttranslational modification] 336982004067 intermolecular recognition site; other site 336982004068 dimerization interface [polypeptide binding]; other site 336982004069 ANTAR domain; Region: ANTAR; pfam03861 336982004070 lipid-transfer protein; Provisional; Region: PRK06059 336982004071 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 336982004072 active site 336982004073 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 336982004074 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 336982004075 DUF35 OB-fold domain; Region: DUF35; pfam01796 336982004076 DNA polymerase I; Provisional; Region: PRK05755 336982004077 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 336982004078 active site 336982004079 metal binding site 1 [ion binding]; metal-binding site 336982004080 putative 5' ssDNA interaction site; other site 336982004081 metal binding site 3; metal-binding site 336982004082 metal binding site 2 [ion binding]; metal-binding site 336982004083 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 336982004084 putative DNA binding site [nucleotide binding]; other site 336982004085 putative metal binding site [ion binding]; other site 336982004086 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 336982004087 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 336982004088 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 336982004089 active site 336982004090 DNA binding site [nucleotide binding] 336982004091 catalytic site [active] 336982004092 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 336982004093 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 336982004094 RNA binding site [nucleotide binding]; other site 336982004095 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 336982004096 RNA binding site [nucleotide binding]; other site 336982004097 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 336982004098 RNA binding site [nucleotide binding]; other site 336982004099 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 336982004100 RNA binding site [nucleotide binding]; other site 336982004101 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 336982004102 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 336982004103 CoA-binding site [chemical binding]; other site 336982004104 ATP-binding [chemical binding]; other site 336982004105 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 336982004106 Protein of unknown function (DUF402); Region: DUF402; cl00979 336982004107 excinuclease ABC subunit B; Provisional; Region: PRK05298 336982004108 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982004109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982004110 nucleotide binding region [chemical binding]; other site 336982004111 ATP-binding site [chemical binding]; other site 336982004112 Ultra-violet resistance protein B; Region: UvrB; pfam12344 336982004113 UvrB/uvrC motif; Region: UVR; pfam02151 336982004114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982004115 putative substrate translocation pore; other site 336982004116 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 336982004117 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982004118 Ligand Binding Site [chemical binding]; other site 336982004119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982004120 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 336982004121 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 336982004122 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 336982004123 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 336982004124 Predicted esterase [General function prediction only]; Region: COG0627 336982004125 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982004126 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 336982004127 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 336982004128 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 336982004129 dimer interface [polypeptide binding]; other site 336982004130 putative anticodon binding site; other site 336982004131 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 336982004132 motif 1; other site 336982004133 dimer interface [polypeptide binding]; other site 336982004134 active site 336982004135 motif 2; other site 336982004136 motif 3; other site 336982004137 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 336982004138 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 336982004139 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 336982004140 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 336982004141 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 336982004142 23S rRNA binding site [nucleotide binding]; other site 336982004143 L21 binding site [polypeptide binding]; other site 336982004144 L13 binding site [polypeptide binding]; other site 336982004145 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 336982004146 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 336982004147 PE family; Region: PE; pfam00934 336982004148 cyclase homology domain; Region: CHD; cd07302 336982004149 nucleotidyl binding site; other site 336982004150 metal binding site [ion binding]; metal-binding site 336982004151 dimer interface [polypeptide binding]; other site 336982004152 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 336982004153 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 336982004154 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 336982004155 dimer interface [polypeptide binding]; other site 336982004156 motif 1; other site 336982004157 active site 336982004158 motif 2; other site 336982004159 motif 3; other site 336982004160 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 336982004161 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 336982004162 putative tRNA-binding site [nucleotide binding]; other site 336982004163 B3/4 domain; Region: B3_4; cl11458 336982004164 tRNA synthetase B5 domain; Region: B5; cl08394 336982004165 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 336982004166 dimer interface [polypeptide binding]; other site 336982004167 motif 1; other site 336982004168 motif 3; other site 336982004169 motif 2; other site 336982004170 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 336982004171 PE family; Region: PE; pfam00934 336982004172 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 336982004173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004174 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 336982004175 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 336982004176 heterotetramer interface [polypeptide binding]; other site 336982004177 active site pocket [active] 336982004178 cleavage site 336982004179 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 336982004180 feedback inhibition sensing region; other site 336982004181 homohexameric interface [polypeptide binding]; other site 336982004182 nucleotide binding site [chemical binding]; other site 336982004183 N-acetyl-L-glutamate binding site [chemical binding]; other site 336982004184 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 336982004185 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 336982004186 inhibitor-cofactor binding pocket; inhibition site 336982004187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982004188 catalytic residue [active] 336982004189 ornithine carbamoyltransferase; Provisional; Region: PRK00779 336982004190 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 336982004191 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 336982004192 arginine repressor; Provisional; Region: PRK03341 336982004193 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 336982004194 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 336982004195 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 336982004196 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 336982004197 ANP binding site [chemical binding]; other site 336982004198 Substrate Binding Site II [chemical binding]; other site 336982004199 Substrate Binding Site I [chemical binding]; other site 336982004200 argininosuccinate lyase; Provisional; Region: PRK00855 336982004201 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 336982004202 active sites [active] 336982004203 tetramer interface [polypeptide binding]; other site 336982004204 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 336982004205 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 336982004206 malonyl-CoA binding site [chemical binding]; other site 336982004207 dimer interface [polypeptide binding]; other site 336982004208 active site 336982004209 product binding site; other site 336982004210 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982004211 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982004212 active site 336982004213 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982004214 PKS_DH; Region: PKS_DH; smart00826 336982004215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004216 Enoylreductase; Region: PKS_ER; smart00829 336982004217 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982004218 NAD(P) binding site [chemical binding]; other site 336982004219 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 336982004220 putative NADP binding site [chemical binding]; other site 336982004221 active site 336982004222 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982004223 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982004224 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982004225 active site 336982004226 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982004227 PKS_DH; Region: PKS_DH; smart00826 336982004228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004229 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982004230 NAD(P) binding site [chemical binding]; other site 336982004231 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 336982004232 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 336982004233 putative NADP binding site [chemical binding]; other site 336982004234 active site 336982004235 acyl-CoA synthetase; Validated; Region: PRK06060 336982004236 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982004237 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 336982004238 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982004239 active site 336982004240 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 336982004241 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982004242 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982004243 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 336982004244 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 336982004245 malonyl-CoA binding site [chemical binding]; other site 336982004246 dimer interface [polypeptide binding]; other site 336982004247 active site 336982004248 product binding site; other site 336982004249 Cytochrome P450; Region: p450; cl12078 336982004250 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 336982004251 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 336982004252 ABC transporter; Region: ABC_tran_2; pfam12848 336982004253 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 336982004254 Domain of unknown function (DUF427); Region: DUF427; cl00998 336982004255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982004256 putative substrate translocation pore; other site 336982004257 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 336982004258 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 336982004259 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982004260 dimerization interface [polypeptide binding]; other site 336982004261 putative DNA binding site [nucleotide binding]; other site 336982004262 putative Zn2+ binding site [ion binding]; other site 336982004263 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 336982004264 active site residue [active] 336982004265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 336982004266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982004267 ligand binding site [chemical binding]; other site 336982004268 flexible hinge region; other site 336982004269 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982004270 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 336982004271 putative catalytic residues [active] 336982004272 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif...; Region: TlpA_like_ScsD_MtbDsbE; cd03011 336982004273 catalytic residues [active] 336982004274 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982004275 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982004276 active site 336982004277 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982004278 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 336982004279 FeS/SAM binding site; other site 336982004280 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 336982004281 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 336982004282 acyl-CoA synthetase; Validated; Region: PRK07868 336982004283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982004284 ABC-2 type transporter; Region: ABC2_membrane; cl11417 336982004285 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 336982004286 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 336982004287 Walker A/P-loop; other site 336982004288 ATP binding site [chemical binding]; other site 336982004289 Q-loop/lid; other site 336982004290 ABC transporter signature motif; other site 336982004291 Walker B; other site 336982004292 D-loop; other site 336982004293 H-loop/switch region; other site 336982004294 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 336982004295 active site 336982004296 DNA binding site [nucleotide binding] 336982004297 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 336982004298 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 336982004299 active site 336982004300 HIGH motif; other site 336982004301 dimer interface [polypeptide binding]; other site 336982004302 KMSKS motif; other site 336982004303 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 336982004304 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982004305 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 336982004306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982004307 active site 336982004308 motif I; other site 336982004309 motif II; other site 336982004310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982004311 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 336982004312 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 336982004313 RNA binding surface [nucleotide binding]; other site 336982004314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982004315 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 336982004316 ATP-NAD kinase; Region: NAD_kinase; pfam01513 336982004317 DNA repair protein RecN; Region: recN; TIGR00634 336982004318 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 336982004319 Walker A/P-loop; other site 336982004320 ATP binding site [chemical binding]; other site 336982004321 Q-loop/lid; other site 336982004322 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 336982004323 Q-loop/lid; other site 336982004324 ABC transporter signature motif; other site 336982004325 Walker B; other site 336982004326 D-loop; other site 336982004327 H-loop/switch region; other site 336982004328 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 336982004329 Thiamine pyrophosphokinase; Region: TPK; cl09135 336982004330 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 336982004331 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 336982004332 CTP synthetase; Validated; Region: pyrG; PRK05380 336982004333 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 336982004334 Catalytic site [active] 336982004335 Active site [active] 336982004336 UTP binding site [chemical binding]; other site 336982004337 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 336982004338 active site 336982004339 putative oxyanion hole; other site 336982004340 catalytic triad [active] 336982004341 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 336982004342 dimer interface [polypeptide binding]; other site 336982004343 ADP-ribose binding site [chemical binding]; other site 336982004344 active site 336982004345 nudix motif; other site 336982004346 metal binding site [ion binding]; metal-binding site 336982004347 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 336982004348 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 336982004349 DNA binding site [nucleotide binding] 336982004350 Int/Topo IB signature motif; other site 336982004351 active site 336982004352 Domain of unknown function DUF222; Region: DUF222; pfam02720 336982004353 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982004354 active site 336982004355 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 336982004356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982004357 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 336982004358 PPE family; Region: PPE; pfam00823 336982004359 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982004360 PPE family; Region: PPE; pfam00823 336982004361 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982004362 Sulfate transporter family; Region: Sulfate_transp; cl00967 336982004363 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 336982004364 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 336982004365 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 336982004366 ScpA/B protein; Region: ScpA_ScpB; cl00598 336982004367 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 336982004368 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 336982004369 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 336982004370 RNA binding surface [nucleotide binding]; other site 336982004371 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 336982004372 active site 336982004373 cytidylate kinase; Provisional; Region: cmk; PRK00023 336982004374 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 336982004375 CMP-binding site; other site 336982004376 The sites determining sugar specificity; other site 336982004377 GTP-binding protein Der; Reviewed; Region: PRK03003 336982004378 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 336982004379 GTP/Mg2+ binding site [chemical binding]; other site 336982004380 Switch I region; other site 336982004381 G2 box; other site 336982004382 Switch II region; other site 336982004383 G3 box; other site 336982004384 G4 box; other site 336982004385 G5 box; other site 336982004386 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 336982004387 G1 box; other site 336982004388 GTP/Mg2+ binding site [chemical binding]; other site 336982004389 Switch I region; other site 336982004390 G2 box; other site 336982004391 G3 box; other site 336982004392 Switch II region; other site 336982004393 G4 box; other site 336982004394 G5 box; other site 336982004395 short chain dehydrogenase; Provisional; Region: PRK06841 336982004396 classical (c) SDRs; Region: SDR_c; cd05233 336982004397 NAD(P) binding site [chemical binding]; other site 336982004398 active site 336982004399 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 336982004400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004401 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 336982004402 Putative cyclase; Region: Cyclase; cl00814 336982004403 Cupin domain; Region: Cupin_2; cl09118 336982004404 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 336982004405 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 336982004406 putative switch regulator; other site 336982004407 non-specific DNA interactions [nucleotide binding]; other site 336982004408 DNA binding site [nucleotide binding] 336982004409 sequence specific DNA binding site [nucleotide binding]; other site 336982004410 putative cAMP binding site [chemical binding]; other site 336982004411 Bacterial transcriptional regulator; Region: IclR; pfam01614 336982004412 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 336982004413 putative active site [active] 336982004414 homotetrameric interface [polypeptide binding]; other site 336982004415 metal binding site [ion binding]; metal-binding site 336982004416 biotin carboxylase-like protein; Validated; Region: PRK06524 336982004417 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 336982004418 Beta-lactamase; Region: Beta-lactamase; cl01009 336982004419 hypothetical protein; Mapped to H37Rv Rv1724c; interrupted by transposases 336982004420 putative transposase OrfB; Reviewed; Region: PHA02517 336982004421 Integrase core domain; Region: rve; cl01316 336982004422 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982004423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982004424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982004425 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982004426 FAD binding domain; Region: FAD_binding_4; pfam01565 336982004427 Berberine and berberine like; Region: BBE; pfam08031 336982004428 TIGR03086 family protein; Region: TIGR03086 336982004429 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982004430 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982004431 Beta-lactamase; Region: Beta-lactamase; cl01009 336982004432 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982004433 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 336982004434 NAD(P) binding site [chemical binding]; other site 336982004435 catalytic residues [active] 336982004436 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 336982004437 putative catalytic residue [active] 336982004438 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 336982004439 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 336982004440 gating phenylalanine in ion channel; other site 336982004441 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 336982004442 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 336982004443 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 336982004444 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 336982004445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982004446 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 336982004447 putative substrate translocation pore; other site 336982004448 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 336982004449 high affinity sulphate transporter 1; Region: sulP; TIGR00815 336982004450 Sulfate transporter family; Region: Sulfate_transp; cl00967 336982004451 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 336982004452 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 336982004453 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982004454 putative active site [active] 336982004455 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982004456 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982004457 active site 336982004458 ATP binding site [chemical binding]; other site 336982004459 substrate binding site [chemical binding]; other site 336982004460 activation loop (A-loop); other site 336982004461 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 336982004462 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 336982004463 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and...; Region: IPP_Isomerase; cd02885 336982004464 active site 336982004465 metal binding site [ion binding]; metal-binding site 336982004466 nudix motif; other site 336982004467 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982004468 active site 336982004469 ATP binding site [chemical binding]; other site 336982004470 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982004471 substrate binding site [chemical binding]; other site 336982004472 activation loop (A-loop); other site 336982004473 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 336982004474 phosphopeptide binding site; other site 336982004475 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 336982004476 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 336982004477 phosphopeptide binding site; other site 336982004478 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 336982004479 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with...; Region: ABCG_EPDR; cd03213 336982004480 Walker A/P-loop; other site 336982004481 ATP binding site [chemical binding]; other site 336982004482 Q-loop/lid; other site 336982004483 ABC transporter signature motif; other site 336982004484 Walker B; other site 336982004485 D-loop; other site 336982004486 H-loop/switch region; other site 336982004487 ABC-2 type transporter; Region: ABC2_membrane; cl11417 336982004488 acyl-CoA synthetase; Provisional; Region: PRK13388 336982004489 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982004490 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982004491 hypothetical protein; Provisional; Region: PRK06185 336982004492 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982004493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982004494 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 336982004495 PPE family; Region: PPE; pfam00823 336982004496 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982004497 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982004498 EBNA-3B; Provisional; Region: PHA03378 336982004499 putative transposase OrfB; Reviewed; Region: PHA02517 336982004500 Integrase core domain; Region: rve; cl01316 336982004501 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982004502 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 336982004503 Phosphoesterase family; Region: Phosphoesterase; cl10627 336982004504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 336982004505 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 336982004506 sulfite oxidase; Provisional; Region: PLN00177 336982004507 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 336982004508 Moco binding site; other site 336982004509 metal coordination site [ion binding]; other site 336982004510 dimerization interface [polypeptide binding]; other site 336982004511 Transport protein; Region: actII; TIGR00833 336982004512 cutinase cut1; Mapped to H37Rv Rv1758; interrupted by transposases 336982004513 putative transposase OrfB; Reviewed; Region: PHA02517 336982004514 Integrase core domain; Region: rve; cl01316 336982004515 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982004516 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982004517 putative transposase OrfB; Reviewed; Region: PHA02517 336982004518 Integrase core domain; Region: rve; cl01316 336982004519 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982004520 Condensation domain; Region: Condensation; cl09290 336982004521 Domain of unknown function (DUF74); Region: DUF74; cl00426 336982004522 Domain of unknown function (DUF74); Region: DUF74; cl00426 336982004523 Domain of unknown function DUF222; Region: DUF222; pfam02720 336982004524 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982004525 active site 336982004526 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982004527 putative transposase OrfB; Reviewed; Region: PHA02517 336982004528 Integrase core domain; Region: rve; cl01316 336982004529 Integrase core domain; Region: rve; cl01316 336982004530 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 336982004531 putative homotetramer interface [polypeptide binding]; other site 336982004532 putative homodimer interface [polypeptide binding]; other site 336982004533 putative allosteric switch controlling residues; other site 336982004534 putative metal binding site [ion binding]; other site 336982004535 putative homodimer-homodimer interface [polypeptide binding]; other site 336982004536 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 336982004537 PE family; Region: PE; pfam00934 336982004538 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 336982004539 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 336982004540 dimer interface [polypeptide binding]; other site 336982004541 active site 336982004542 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 336982004543 substrate binding site [chemical binding]; other site 336982004544 catalytic residue [active] 336982004545 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 336982004546 M28, and M42; Region: Zinc_peptidase_like; cl14876 336982004547 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 336982004548 FAD binding domain; Region: FAD_binding_4; pfam01565 336982004549 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 336982004550 ANTAR domain; Region: ANTAR; pfam03861 336982004551 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982004552 Transcriptional regulator [Transcription]; Region: IclR; COG1414 336982004553 Bacterial transcriptional regulator; Region: IclR; pfam01614 336982004554 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982004555 FAD binding domain; Region: FAD_binding_4; pfam01565 336982004556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982004557 cytochrome p450 144 CYP144; Mapped to H37Rv Rv1777; interrupted by transposase 336982004558 putative transposase OrfB; Reviewed; Region: PHA02517 336982004559 Integrase core domain; Region: rve; cl01316 336982004560 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982004561 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 336982004562 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 336982004563 Protein of unknown function (DUF690); Region: DUF690; cl04939 336982004564 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 336982004565 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982004566 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 336982004567 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982004568 Cytochrome P450; Region: p450; cl12078 336982004569 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 336982004570 PPE family; Region: PPE; pfam00823 336982004571 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982004572 PE family; Region: PE; pfam00934 336982004573 PPE family; Region: PPE; pfam00823 336982004574 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982004575 PPE family; Region: PPE; pfam00823 336982004576 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982004577 PE family; Region: PE; pfam00934 336982004578 Esat-6 like protein esxM; Mapped to H37Rv Rv1792 336982004579 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982004580 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 336982004581 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 336982004582 catalytic residues [active] 336982004583 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 336982004584 active site 336982004585 catalytic residues [active] 336982004586 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 336982004587 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 336982004588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982004589 Walker A motif; other site 336982004590 ATP binding site [chemical binding]; other site 336982004591 Walker B motif; other site 336982004592 arginine finger; other site 336982004593 PPE family; Region: PPE; pfam00823 336982004594 PE-PPE domain; Region: PE-PPE; pfam08237 336982004595 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982004596 PPE family; Region: PPE; pfam00823 336982004597 PPE family; Region: PPE; pfam00823 336982004598 PE family; Region: PE; pfam00934 336982004599 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982004600 PE family; Region: PE; pfam00934 336982004601 PPE family; Region: PPE; pfam00823 336982004602 PPE family; Region: PPE; pfam00823 336982004603 PPE family; Region: PPE; pfam00823 336982004604 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982004605 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 336982004606 MgtC family; Region: MgtC; cl12207 336982004607 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 336982004608 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 336982004609 hypothetical protein; Validated; Region: PRK07121 336982004610 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982004611 PE family; Region: PE; pfam00934 336982004612 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 336982004613 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 336982004614 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 336982004615 hypothetical protein; Provisional; Region: PRK05858 336982004616 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 336982004617 PYR/PP interface [polypeptide binding]; other site 336982004618 dimer interface [polypeptide binding]; other site 336982004619 TPP binding site [chemical binding]; other site 336982004620 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 336982004621 TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules...; Region: TPP_BZL_OCoD_HPCL; cd02004 336982004622 TPP-binding site; other site 336982004623 dimer interface [polypeptide binding]; other site 336982004624 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 336982004625 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 336982004626 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982004627 nucleotide binding region [chemical binding]; other site 336982004628 ATP-binding site [chemical binding]; other site 336982004629 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 336982004630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 336982004631 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 336982004632 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 336982004633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 336982004634 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 336982004635 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 336982004636 lipoyl attachment site [posttranslational modification]; other site 336982004637 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 336982004638 phosphopeptide binding site; other site 336982004639 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 336982004640 DNA binding residues [nucleotide binding] 336982004641 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 336982004642 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 336982004643 DNA binding residues [nucleotide binding] 336982004644 putative dimer interface [polypeptide binding]; other site 336982004645 glycine dehydrogenase; Provisional; Region: PRK05367 336982004646 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 336982004647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982004648 tetramer interface [polypeptide binding]; other site 336982004649 catalytic residue [active] 336982004650 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 336982004651 tetramer interface [polypeptide binding]; other site 336982004652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982004653 catalytic residue [active] 336982004654 haloalkane dehalogenase; Provisional; Region: PRK03204 336982004655 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982004656 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 336982004657 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 336982004658 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_ywmD_type; cd01456 336982004659 metal ion-dependent adhesion site (MIDAS); other site 336982004660 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 336982004661 active site 336982004662 FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 336982004663 putative active site [active] 336982004664 Domain of unknown function DUF21; Region: DUF21; pfam01595 336982004665 FOG: CBS domain [General function prediction only]; Region: COG0517 336982004666 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 336982004667 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 336982004668 Domain of unknown function DUF21; Region: DUF21; pfam01595 336982004669 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 336982004670 Transporter associated domain; Region: CorC_HlyC; pfam03471 336982004671 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 336982004672 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 336982004673 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 336982004674 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 336982004675 active site 336982004676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004677 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 336982004678 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 336982004679 Peptidase family M48; Region: Peptidase_M48; cl12018 336982004680 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982004681 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 336982004682 CoenzymeA binding site [chemical binding]; other site 336982004683 subunit interaction site [polypeptide binding]; other site 336982004684 PHB binding site; other site 336982004685 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 336982004686 alpha-gamma subunit interface [polypeptide binding]; other site 336982004687 beta-gamma subunit interface [polypeptide binding]; other site 336982004688 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 336982004689 gamma-beta subunit interface [polypeptide binding]; other site 336982004690 alpha-beta subunit interface [polypeptide binding]; other site 336982004691 urease subunit alpha; Reviewed; Region: ureC; PRK13206 336982004692 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 336982004693 subunit interactions [polypeptide binding]; other site 336982004694 active site 336982004695 flap region; other site 336982004696 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 336982004697 UreF; Region: UreF; pfam01730 336982004698 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 336982004699 UreD urease accessory protein; Region: UreD; cl00530 336982004700 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 336982004701 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982004702 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982004703 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 336982004704 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 336982004705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004706 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 336982004707 NAD(P) binding site [chemical binding]; other site 336982004708 active site 336982004709 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982004710 sulfate transport protein; Provisional; Region: cysT; CHL00187 336982004711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 336982004712 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 336982004713 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982004714 Walker A/P-loop; other site 336982004715 ATP binding site [chemical binding]; other site 336982004716 Q-loop/lid; other site 336982004717 ABC transporter signature motif; other site 336982004718 Walker B; other site 336982004719 D-loop; other site 336982004720 H-loop/switch region; other site 336982004721 TOBE domain; Region: TOBE_2; cl01440 336982004722 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 336982004723 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 336982004724 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 336982004725 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 336982004726 putative NAD(P) binding site [chemical binding]; other site 336982004727 putative substrate binding site [chemical binding]; other site 336982004728 catalytic Zn binding site [ion binding]; other site 336982004729 structural Zn binding site [ion binding]; other site 336982004730 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 336982004731 MOSC domain; Region: MOSC; pfam03473 336982004732 short chain dehydrogenase; Provisional; Region: PRK07825 336982004733 classical (c) SDRs; Region: SDR_c; cd05233 336982004734 NAD(P) binding site [chemical binding]; other site 336982004735 active site 336982004736 CoA-transferase family III; Region: CoA_transf_3; cl00778 336982004737 CoA-transferase family III; Region: CoA_transf_3; cl00778 336982004738 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 336982004739 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 336982004740 active site 336982004741 hypothetical protein; Provisional; Region: PRK05865 336982004742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 336982004744 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982004745 Domain of unknown function (DUF385); Region: DUF385; cl04387 336982004746 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 336982004747 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 336982004748 active site 336982004749 substrate binding site [chemical binding]; other site 336982004750 FMN binding site [chemical binding]; other site 336982004751 putative catalytic residues [active] 336982004752 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 336982004753 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 336982004754 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 336982004755 Ferritin-like domain; Region: Ferritin; pfam00210 336982004756 heme binding site [chemical binding]; other site 336982004757 ferroxidase pore; other site 336982004758 ferroxidase diiron center [ion binding]; other site 336982004759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982004760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982004761 putative substrate translocation pore; other site 336982004762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982004763 putative substrate translocation pore; other site 336982004764 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 336982004765 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 336982004766 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 336982004767 Cytochrome P450; Region: p450; cl12078 336982004768 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 336982004769 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 336982004770 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 336982004771 putative NAD(P) binding site [chemical binding]; other site 336982004772 active site 336982004773 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 336982004774 hydrophobic ligand binding site; other site 336982004775 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 336982004776 Chorismate mutase type II; Region: CM_2; cl00693 336982004777 Predicted esterase [General function prediction only]; Region: COG0627 336982004778 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982004779 YceI-like domain; Region: YceI; cl01001 336982004780 Nitronate monooxygenase; Region: NMO; pfam03060 336982004781 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 336982004782 FMN binding site [chemical binding]; other site 336982004783 substrate binding site [chemical binding]; other site 336982004784 putative catalytic residue [active] 336982004785 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 336982004786 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 336982004787 catalytic Zn binding site [ion binding]; other site 336982004788 NAD(P) binding site [chemical binding]; other site 336982004789 structural Zn binding site [ion binding]; other site 336982004790 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982004791 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 336982004792 putative active site [active] 336982004793 dimerization interface [polypeptide binding]; other site 336982004794 putative tRNAtyr binding site [nucleotide binding]; other site 336982004795 Domain of unknown function DUF77; Region: DUF77; cl00307 336982004796 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_2; cd03330 336982004797 putative ADP-ribose binding site [chemical binding]; other site 336982004798 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982004799 cyclase homology domain; Region: CHD; cd07302 336982004800 nucleotidyl binding site; other site 336982004801 metal binding site [ion binding]; metal-binding site 336982004802 dimer interface [polypeptide binding]; other site 336982004803 competence damage-inducible protein A; Provisional; Region: PRK00549 336982004804 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 336982004805 putative MPT binding site; other site 336982004806 Competence-damaged protein; Region: CinA; cl00666 336982004807 putative sialic acid transporter; Region: 2A0112; TIGR00891 336982004808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982004809 putative substrate translocation pore; other site 336982004810 Membrane protein of unknown function; Region: DUF360; cl00850 336982004811 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 336982004812 anti sigma factor interaction site; other site 336982004813 regulatory phosphorylation site [posttranslational modification]; other site 336982004814 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 336982004815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982004816 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 336982004817 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 336982004818 dimer interface [polypeptide binding]; other site 336982004819 active site 336982004820 heme binding site [chemical binding]; other site 336982004821 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 336982004822 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 336982004823 metal binding site 2 [ion binding]; metal-binding site 336982004824 putative DNA binding helix; other site 336982004825 metal binding site 1 [ion binding]; metal-binding site 336982004826 dimer interface [polypeptide binding]; other site 336982004827 structural Zn2+ binding site [ion binding]; other site 336982004828 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 336982004829 substrate binding site [chemical binding]; other site 336982004830 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 336982004831 substrate binding site [chemical binding]; other site 336982004832 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 336982004833 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 336982004834 putative NAD(P) binding site [chemical binding]; other site 336982004835 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982004836 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 336982004837 tetramer interface [polypeptide binding]; other site 336982004838 active site 336982004839 Mg2+/Mn2+ binding site [ion binding]; other site 336982004840 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 336982004841 PPE family; Region: PPE; pfam00823 336982004842 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982004843 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982004844 PPE family; Region: PPE; pfam00823 336982004845 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982004846 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982004847 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 336982004848 putative hydrophobic ligand binding site [chemical binding]; other site 336982004849 protein interface [polypeptide binding]; other site 336982004850 gate; other site 336982004851 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 336982004852 putative acyl-acceptor binding pocket; other site 336982004853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982004854 Beta-lactamase; Region: Beta-lactamase; cl01009 336982004855 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982004856 Beta-lactamase; Region: Beta-lactamase; cl01009 336982004857 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 336982004858 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982004859 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 336982004860 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 336982004861 short chain dehydrogenase; Provisional; Region: PRK05867 336982004862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004863 NAD(P) binding site [chemical binding]; other site 336982004864 active site 336982004865 TIGR03085 family protein; Region: TIGR03085 336982004866 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 336982004867 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 336982004868 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 336982004869 conserved cys residue [active] 336982004870 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 336982004871 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 336982004872 dimer interface [polypeptide binding]; other site 336982004873 catalytic triad [active] 336982004874 peroxidatic and resolving cysteines [active] 336982004875 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982004876 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 336982004877 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 336982004878 active site 336982004879 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982004880 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 336982004881 FAD binding site [chemical binding]; other site 336982004882 substrate binding site [chemical binding]; other site 336982004883 catalytic base [active] 336982004884 enoyl-CoA hydratase; Provisional; Region: PRK08290 336982004885 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982004886 substrate binding site [chemical binding]; other site 336982004887 oxyanion hole (OAH) forming residues; other site 336982004888 trimer interface [polypeptide binding]; other site 336982004889 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982004890 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 336982004891 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 336982004892 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982004893 catalytic loop [active] 336982004894 iron binding site [ion binding]; other site 336982004895 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 336982004896 FAD binding pocket [chemical binding]; other site 336982004897 FAD binding motif [chemical binding]; other site 336982004898 phosphate binding motif [ion binding]; other site 336982004899 beta-alpha-beta structure motif; other site 336982004900 NAD binding pocket [chemical binding]; other site 336982004901 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 336982004902 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982004903 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982004904 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 336982004905 Flavin Reductases; Region: FlaRed; cl00801 336982004906 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 336982004907 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 336982004908 dimerization interface [polypeptide binding]; other site 336982004909 active site 336982004910 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 336982004911 putative NAD(P) binding site [chemical binding]; other site 336982004912 active site 336982004913 homodimer interface [polypeptide binding]; other site 336982004914 PemK-like protein; Region: PemK; cl00995 336982004915 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900 336982004916 SEC-C motif; Region: SEC-C; cl12132 336982004917 Domain of unknown function DUF222; Region: DUF222; pfam02720 336982004918 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982004919 active site 336982004920 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 336982004921 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982004922 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 336982004923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 336982004924 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 336982004925 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 336982004926 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 336982004927 putative active site [active] 336982004928 Phd_YefM; Region: PhdYeFM; cl09153 336982004929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982004930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982004931 Domain of unknown function DUF140; Region: DUF140; cl00510 336982004932 Domain of unknown function DUF140; Region: DUF140; cl00510 336982004933 Domain of unknown function DUF140; Region: DUF140; cl00510 336982004934 mce related protein; Region: MCE; cl03606 336982004935 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 336982004936 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982004937 mce related protein; Region: MCE; cl03606 336982004938 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982004939 mce related protein; Region: MCE; cl03606 336982004940 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982004941 mce related protein; Region: MCE; cl03606 336982004942 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982004943 mce related protein; Region: MCE; cl03606 336982004944 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982004945 mce related protein; Region: MCE; cl03606 336982004946 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982004947 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 336982004948 YacP-like NYN domain; Region: NYN_YacP; cl01491 336982004949 Peptidase family M48; Region: Peptidase_M48; cl12018 336982004950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982004951 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 336982004952 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 336982004953 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 336982004954 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 336982004955 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 336982004956 dimer interface [polypeptide binding]; other site 336982004957 putative radical transfer pathway; other site 336982004958 diiron center [ion binding]; other site 336982004959 tyrosyl radical; other site 336982004960 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 336982004961 putative active site [active] 336982004962 PE family; Region: PE; pfam00934 336982004963 Cutinase; Region: Cutinase; pfam01083 336982004964 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 336982004965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982004966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982004967 dimerization interface [polypeptide binding]; other site 336982004968 LysE type translocator; Region: LysE; cl00565 336982004969 Cellulose binding domain; Region: CBM_2; cl02709 336982004970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982004971 S-adenosylmethionine binding site [chemical binding]; other site 336982004972 RES domain; Region: RES; cl02411 336982004973 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 336982004974 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 336982004975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982004976 PemK-like protein; Region: PemK; cl00995 336982004977 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 336982004978 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982004979 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 336982004980 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982004981 dimerization interface [polypeptide binding]; other site 336982004982 putative DNA binding site [nucleotide binding]; other site 336982004983 putative Zn2+ binding site [ion binding]; other site 336982004984 Uncharacterized conserved protein [Function unknown]; Region: COG3945 336982004985 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 336982004986 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982004987 Ligand Binding Site [chemical binding]; other site 336982004988 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 336982004989 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 336982004990 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982004991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982004992 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 336982004993 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 336982004994 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 336982004995 tetramer interface [polypeptide binding]; other site 336982004996 active site 336982004997 Mg2+/Mn2+ binding site [ion binding]; other site 336982004998 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 336982004999 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 336982005000 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 336982005001 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 336982005002 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 336982005003 homotetramer interface [polypeptide binding]; other site 336982005004 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 336982005005 NAD binding site [chemical binding]; other site 336982005006 homodimer interface [polypeptide binding]; other site 336982005007 active site 336982005008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982005009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 336982005010 Predicted kinase [General function prediction only]; Region: COG0645 336982005011 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982005012 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 336982005013 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982005014 Ligand Binding Site [chemical binding]; other site 336982005015 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 336982005016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982005017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982005018 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 336982005019 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 336982005020 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 336982005021 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 336982005022 Ferredoxin [Energy production and conversion]; Region: COG1146 336982005023 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 336982005024 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 336982005025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982005026 Walker A motif; other site 336982005027 ATP binding site [chemical binding]; other site 336982005028 Walker B motif; other site 336982005029 arginine finger; other site 336982005030 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 336982005031 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982005032 putative active site [active] 336982005033 Transcriptional regulators [Transcription]; Region: MarR; COG1846 336982005034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982005035 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 336982005036 Transposase; Region: DEDD_Tnp_IS110; pfam01548 336982005037 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 336982005038 conserved hypothetical protein; Mapped to H37Rv Rv2015c; interrupted by transposases 336982005039 putative transposase OrfB; Reviewed; Region: PHA02517 336982005040 Integrase core domain; Region: rve; cl01316 336982005041 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982005042 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 336982005043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982005044 non-specific DNA binding site [nucleotide binding]; other site 336982005045 salt bridge; other site 336982005046 sequence-specific DNA binding site [nucleotide binding]; other site 336982005047 Domain of unknown function (DUF955); Region: DUF955; cl01076 336982005048 Protein of unknown function (DUF433); Region: DUF433; cl01030 336982005049 hypothetical helicase; Mapped to H37Rv Rv2020c; interrupted gene 336982005050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 336982005051 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 336982005052 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 336982005053 Cation efflux family; Region: Cation_efflux; cl00316 336982005054 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982005055 Ligand Binding Site [chemical binding]; other site 336982005056 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982005057 Ligand Binding Site [chemical binding]; other site 336982005058 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 336982005059 GAF domain; Region: GAF; cl00853 336982005060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 336982005061 Histidine kinase; Region: HisKA_3; pfam07730 336982005062 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 336982005063 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 336982005064 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 336982005065 putative substrate binding site [chemical binding]; other site 336982005066 putative ATP binding site [chemical binding]; other site 336982005067 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 336982005068 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 336982005069 Erythromycin esterase; Region: Erythro_esteras; pfam05139 336982005070 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 336982005071 putative dimer interface [polypeptide binding]; other site 336982005072 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 336982005073 hypothetical protein; Provisional; Region: PRK07877 336982005074 dimer interface [polypeptide binding]; other site 336982005075 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 336982005076 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982005077 putative DNA binding site [nucleotide binding]; other site 336982005078 dimerization interface [polypeptide binding]; other site 336982005079 putative Zn2+ binding site [ion binding]; other site 336982005080 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 336982005081 putative hydrophobic ligand binding site [chemical binding]; other site 336982005082 CLM binding site; other site 336982005083 L1 loop; other site 336982005084 DNA binding site [nucleotide binding] 336982005085 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 336982005086 DinB superfamily; Region: DinB_2; cl00986 336982005087 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 336982005088 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 336982005089 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 336982005090 nucleophile elbow; other site 336982005091 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 336982005092 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 336982005093 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 336982005094 Walker A/P-loop; other site 336982005095 ATP binding site [chemical binding]; other site 336982005096 Q-loop/lid; other site 336982005097 ABC transporter signature motif; other site 336982005098 Walker B; other site 336982005099 D-loop; other site 336982005100 H-loop/switch region; other site 336982005101 TOBE domain; Region: TOBE_2; cl01440 336982005102 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 336982005103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982005104 dimer interface [polypeptide binding]; other site 336982005105 conserved gate region; other site 336982005106 putative PBP binding loops; other site 336982005107 ABC-ATPase subunit interface; other site 336982005108 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 336982005109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982005110 dimer interface [polypeptide binding]; other site 336982005111 conserved gate region; other site 336982005112 putative PBP binding loops; other site 336982005113 ABC-ATPase subunit interface; other site 336982005114 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 336982005115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982005116 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982005117 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 336982005118 Isochorismatase family; Region: Isochorismatase; pfam00857 336982005119 catalytic triad [active] 336982005120 metal binding site [ion binding]; metal-binding site 336982005121 conserved cis-peptide bond; other site 336982005122 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 336982005123 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 336982005124 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982005125 substrate binding pocket [chemical binding]; other site 336982005126 catalytic triad [active] 336982005127 hypothetical protein; Provisional; Region: PRK05865 336982005128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982005129 NAD(P) binding site [chemical binding]; other site 336982005130 active site 336982005131 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 336982005132 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982005133 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982005134 active site 336982005135 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982005136 PKS_DH; Region: PKS_DH; smart00826 336982005137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982005138 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982005139 Enoylreductase; Region: PKS_ER; smart00829 336982005140 NAD(P) binding site [chemical binding]; other site 336982005141 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 336982005142 putative NADP binding site [chemical binding]; other site 336982005143 active site 336982005144 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982005145 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982005146 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982005147 active site 336982005148 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982005149 PKS_DH; Region: PKS_DH; smart00826 336982005150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982005151 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982005152 Enoylreductase; Region: PKS_ER; smart00829 336982005153 NAD(P) binding site [chemical binding]; other site 336982005154 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 336982005155 putative NADP binding site [chemical binding]; other site 336982005156 active site 336982005157 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982005158 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 336982005159 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 336982005160 putative active site [active] 336982005161 catalytic triad [active] 336982005162 putative dimer interface [polypeptide binding]; other site 336982005163 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 336982005164 Ligand binding site [chemical binding]; other site 336982005165 Putative Catalytic site [active] 336982005166 DXD motif; other site 336982005167 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 336982005168 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 336982005169 active site 336982005170 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 336982005171 Dienelactone hydrolase family; Region: DLH; pfam01738 336982005172 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982005173 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 336982005174 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 336982005175 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 336982005176 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 336982005177 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 336982005178 intersubunit interface [polypeptide binding]; other site 336982005179 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 336982005180 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 336982005181 precorrin-3B synthase; Region: CobG; TIGR02435 336982005182 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 336982005183 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 336982005184 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 336982005185 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 336982005186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982005187 S-adenosylmethionine binding site [chemical binding]; other site 336982005188 Beta-lactamase; Region: Beta-lactamase; cl01009 336982005189 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 336982005190 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982005191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 336982005192 DNA binding residues [nucleotide binding] 336982005193 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 336982005194 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 336982005195 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 336982005196 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 336982005197 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 336982005198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982005199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982005200 NAD(P) binding site [chemical binding]; other site 336982005201 active site 336982005202 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 336982005203 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 336982005204 putative active site [active] 336982005205 catalytic site [active] 336982005206 putative metal binding site [ion binding]; other site 336982005207 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 336982005208 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982005209 putative transposase OrfB; Reviewed; Region: PHA02517 336982005210 Integrase core domain; Region: rve; cl01316 336982005211 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 336982005212 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982005213 active site 336982005214 ATP binding site [chemical binding]; other site 336982005215 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982005216 substrate binding site [chemical binding]; other site 336982005217 activation loop (A-loop); other site 336982005218 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 336982005219 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 336982005220 active site 336982005221 autotransport protein MisL; Provisional; Region: PRK15313 336982005222 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 336982005223 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 336982005224 active site 336982005225 metal binding site 1 [ion binding]; metal-binding site 336982005226 putative 5' ssDNA interaction site; other site 336982005227 metal binding site 3; metal-binding site 336982005228 metal binding site 2 [ion binding]; metal-binding site 336982005229 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 336982005230 putative DNA binding site [nucleotide binding]; other site 336982005231 putative metal binding site [ion binding]; other site 336982005232 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 336982005233 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982005234 ATP binding site [chemical binding]; other site 336982005235 putative Mg++ binding site [ion binding]; other site 336982005236 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982005237 nucleotide binding region [chemical binding]; other site 336982005238 ATP-binding site [chemical binding]; other site 336982005239 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 336982005240 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 336982005241 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 336982005242 Predicted transcriptional regulator [Transcription]; Region: COG2378 336982005243 Predicted transcriptional regulator [Transcription]; Region: COG2378 336982005244 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 336982005245 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 336982005246 Domain of unknown function DUF222; Region: DUF222; pfam02720 336982005247 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982005248 active site 336982005249 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 336982005250 SNF2 Helicase protein; Region: DUF3670; pfam12419 336982005251 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982005252 ATP binding site [chemical binding]; other site 336982005253 putative Mg++ binding site [ion binding]; other site 336982005254 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982005255 nucleotide binding region [chemical binding]; other site 336982005256 ATP-binding site [chemical binding]; other site 336982005257 Uncharacterized conserved protein [Function unknown]; Region: COG4279 336982005258 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982005259 PPE family; Region: PPE; pfam00823 336982005260 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 336982005261 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 336982005262 active site 336982005263 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]; Region: PRE1; COG0638 336982005264 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 336982005265 active site 336982005266 Pup-like protein; Region: Pup; cl05289 336982005267 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 336982005268 Pup-ligase protein; Region: Pup_ligase; pfam03136 336982005269 proteasome ATPase; Region: pup_AAA; TIGR03689 336982005270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982005271 Walker A motif; other site 336982005272 ATP binding site [chemical binding]; other site 336982005273 Walker B motif; other site 336982005274 arginine finger; other site 336982005275 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 336982005276 Protein of unknown function (DUF503); Region: DUF503; cl00669 336982005277 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 336982005278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982005279 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 336982005280 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 336982005281 Predicted membrane protein [Function unknown]; Region: COG3918 336982005282 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 336982005283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982005284 HisG, C-terminal domain; Region: HisG_C; cl06867 336982005285 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 336982005286 PPE family; Region: PPE; pfam00823 336982005287 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 336982005288 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 336982005289 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 336982005290 substrate binding pocket [chemical binding]; other site 336982005291 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 336982005292 B12 binding site [chemical binding]; other site 336982005293 cobalt ligand [ion binding]; other site 336982005294 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 336982005295 PAC2 family; Region: PAC2; cl00847 336982005296 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 336982005297 short chain dehydrogenase; Provisional; Region: PRK05872 336982005298 classical (c) SDRs; Region: SDR_c; cd05233 336982005299 NAD(P) binding site [chemical binding]; other site 336982005300 active site 336982005301 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 336982005302 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 336982005303 active site 336982005304 HIGH motif; other site 336982005305 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982005306 active site 336982005307 KMSKS motif; other site 336982005308 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 336982005309 putative tRNA binding surface [nucleotide binding]; other site 336982005310 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 336982005311 active site 336982005312 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (...; Region: PI3Kc_like; cl00119 336982005313 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 336982005314 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982005315 catalytic core [active] 336982005316 Bacitracin resistance protein BacA; Region: BacA; cl00858 336982005317 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 336982005318 quinone interaction residues [chemical binding]; other site 336982005319 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 336982005320 active site 336982005321 catalytic residues [active] 336982005322 FMN binding site [chemical binding]; other site 336982005323 substrate binding site [chemical binding]; other site 336982005324 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 336982005325 substrate binding site [chemical binding]; other site 336982005326 hypothetical protein; Provisional; Region: PRK07906 336982005327 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 336982005328 putative metal binding site [ion binding]; other site 336982005329 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 336982005330 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 336982005331 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 336982005332 DivIVA domain; Region: DivI1A_domain; TIGR03544 336982005333 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 336982005334 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 336982005335 YGGT family; Region: YGGT; cl00508 336982005336 Protein of unknown function (DUF552); Region: DUF552; cl00775 336982005337 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 336982005338 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 336982005339 catalytic residue [active] 336982005340 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 336982005341 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 336982005342 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 336982005343 nucleotide binding site [chemical binding]; other site 336982005344 SulA interaction site; other site 336982005345 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 336982005346 Cell division protein FtsQ; Region: FtsQ; pfam03799 336982005347 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 336982005348 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 336982005349 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 336982005350 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 336982005351 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 336982005352 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 336982005353 active site 336982005354 homodimer interface [polypeptide binding]; other site 336982005355 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 336982005356 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 336982005357 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 336982005358 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 336982005359 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 336982005360 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 336982005361 Mg++ binding site [ion binding]; other site 336982005362 putative catalytic motif [active] 336982005363 putative substrate binding site [chemical binding]; other site 336982005364 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 336982005365 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 336982005366 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 336982005367 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 336982005368 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 336982005369 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 336982005370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982005371 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 336982005372 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982005373 PE family; Region: PE; pfam00934 336982005374 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 336982005375 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 336982005376 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 336982005377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982005378 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 336982005379 cell division protein MraZ; Reviewed; Region: PRK00326 336982005380 MraZ protein; Region: MraZ; pfam02381 336982005381 MraZ protein; Region: MraZ; pfam02381 336982005382 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 336982005383 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 336982005384 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 336982005385 substrate binding pocket [chemical binding]; other site 336982005386 chain length determination region; other site 336982005387 substrate-Mg2+ binding site; other site 336982005388 catalytic residues [active] 336982005389 aspartate-rich region 1; other site 336982005390 active site lid residues [active] 336982005391 aspartate-rich region 2; other site 336982005392 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 336982005393 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982005394 active site 336982005395 ATP binding site [chemical binding]; other site 336982005396 substrate binding site [chemical binding]; other site 336982005397 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982005398 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 336982005399 substrate binding site [chemical binding]; other site 336982005400 activation loop (A-loop); other site 336982005401 activation loop (A-loop); other site 336982005402 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 336982005403 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 336982005404 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 336982005405 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 336982005406 putative acyl-acceptor binding pocket; other site 336982005407 arsenite-activated ATPase ArsA; Region: arsA; TIGR00345 336982005408 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 336982005409 dimerization interface [polypeptide binding]; other site 336982005410 Metal binding site [ion binding]; metal-binding site 336982005411 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 336982005412 putative hydrophobic ligand binding site [chemical binding]; other site 336982005413 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 336982005414 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982005415 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 336982005416 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 336982005417 NlpC/P60 family; Region: NLPC_P60; cl11438 336982005418 hypothetical protein; Validated; Region: PRK07883 336982005419 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 336982005420 active site 336982005421 substrate binding site [chemical binding]; other site 336982005422 catalytic site [active] 336982005423 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 336982005424 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 336982005425 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 336982005426 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 336982005427 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 336982005428 Subunit I/III interface [polypeptide binding]; other site 336982005429 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 336982005430 Cytochrome c; Region: Cytochrom_C; cl11414 336982005431 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 336982005432 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 336982005433 iron-sulfur cluster [ion binding]; other site 336982005434 [2Fe-2S] cluster binding site [ion binding]; other site 336982005435 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 336982005436 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 336982005437 heme bH binding site [chemical binding]; other site 336982005438 intrachain domain interface; other site 336982005439 heme bL binding site [chemical binding]; other site 336982005440 interchain domain interface [polypeptide binding]; other site 336982005441 Qo binding site; other site 336982005442 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 336982005443 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 336982005444 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 336982005445 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 336982005446 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 336982005447 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 336982005448 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 336982005449 dimer interface [polypeptide binding]; other site 336982005450 active site 336982005451 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 336982005452 Ligand Binding Site [chemical binding]; other site 336982005453 Molecular Tunnel; other site 336982005454 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 336982005455 substrate binding site [chemical binding]; other site 336982005456 ATP binding site [chemical binding]; other site 336982005457 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 336982005458 Glycerate kinase family; Region: Gly_kinase; cl00841 336982005459 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 336982005460 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 336982005461 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 336982005462 putative dimer interface [polypeptide binding]; other site 336982005463 active site pocket [active] 336982005464 putative cataytic base [active] 336982005465 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 336982005466 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 336982005467 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 336982005468 homodimer interface [polypeptide binding]; other site 336982005469 substrate-cofactor binding pocket; other site 336982005470 catalytic residue [active] 336982005471 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 336982005472 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 336982005473 cyclase homology domain; Region: CHD; cd07302 336982005474 nucleotidyl binding site; other site 336982005475 metal binding site [ion binding]; metal-binding site 336982005476 dimer interface [polypeptide binding]; other site 336982005477 multifunctional aminopeptidase A; Provisional; Region: PRK00913 336982005478 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 336982005479 interface (dimer of trimers) [polypeptide binding]; other site 336982005480 Substrate-binding/catalytic site; other site 336982005481 Zn-binding sites [ion binding]; other site 336982005482 short chain dehydrogenase; Validated; Region: PRK05855 336982005483 classical (c) SDRs; Region: SDR_c; cd05233 336982005484 NAD(P) binding site [chemical binding]; other site 336982005485 active site 336982005486 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 336982005487 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 336982005488 E3 interaction surface; other site 336982005489 lipoyl attachment site [posttranslational modification]; other site 336982005490 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 336982005491 E3 interaction surface; other site 336982005492 lipoyl attachment site [posttranslational modification]; other site 336982005493 e3 binding domain; Region: E3_binding; pfam02817 336982005494 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 336982005495 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 336982005496 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 336982005497 putative NAD(P) binding site [chemical binding]; other site 336982005498 putative active site [active] 336982005499 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 336982005500 lipoyl synthase; Provisional; Region: PRK05481 336982005501 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 336982005502 FeS/SAM binding site; other site 336982005503 RDD family; Region: RDD; cl00746 336982005504 glutamine synthetase, type I; Region: GlnA; TIGR00653 336982005505 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 336982005506 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 336982005507 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 336982005508 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 336982005509 metal binding triad; other site 336982005510 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 336982005511 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 336982005512 metal binding triad; other site 336982005513 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 336982005514 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 336982005515 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 336982005516 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 336982005517 stage V sporulation protein AD; Validated; Region: PRK08304 336982005518 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 336982005519 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982005520 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 336982005521 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982005522 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 336982005523 oligomerization interface [polypeptide binding]; other site 336982005524 active site 336982005525 metal binding site [ion binding]; metal-binding site 336982005526 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 336982005527 putative active site; other site 336982005528 putative metal binding residues [ion binding]; other site 336982005529 signature motif; other site 336982005530 putative triphosphate binding site [ion binding]; other site 336982005531 CHAD domain; Region: CHAD; cl10506 336982005532 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl01578 336982005533 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 336982005534 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 336982005535 RNA/DNA hybrid binding site [nucleotide binding]; other site 336982005536 active site 336982005537 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982005538 catalytic core [active] 336982005539 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 336982005540 Putative zinc ribbon domain; Region: DUF164; pfam02591 336982005541 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 336982005542 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 336982005543 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 336982005544 hypothetical protein; Provisional; Region: PRK07908 336982005545 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982005546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982005547 homodimer interface [polypeptide binding]; other site 336982005548 catalytic residue [active] 336982005549 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982005550 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 336982005551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 336982005552 active site 336982005553 motif I; other site 336982005554 motif II; other site 336982005555 Low molecular weight phosphatase family; Region: LMWPc; cd00115 336982005556 Active site [active] 336982005557 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 336982005558 CobD/Cbib protein; Region: CobD_Cbib; cl00561 336982005559 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 336982005560 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 336982005561 dimer interface [polypeptide binding]; other site 336982005562 catalytic triad [active] 336982005563 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 336982005564 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 336982005565 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 336982005566 dimer interface [polypeptide binding]; other site 336982005567 TPP-binding site [chemical binding]; other site 336982005568 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 336982005569 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982005570 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 336982005571 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982005572 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 336982005573 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 336982005574 dimer interface [polypeptide binding]; other site 336982005575 active site 336982005576 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 336982005577 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 336982005578 dimer interface [polypeptide binding]; other site 336982005579 active site 336982005580 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 336982005581 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 336982005582 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 336982005583 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 336982005584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982005585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982005586 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982005587 FAD binding domain; Region: FAD_binding_4; pfam01565 336982005588 diacylglycerol kinase; Reviewed; Region: PRK11914 336982005589 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 336982005590 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 336982005591 Beta-lactamase; Region: Beta-lactamase; cl01009 336982005592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982005593 S-adenosylmethionine binding site [chemical binding]; other site 336982005594 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 336982005595 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 336982005596 NAD binding site [chemical binding]; other site 336982005597 catalytic Zn binding site [ion binding]; other site 336982005598 substrate binding site [chemical binding]; other site 336982005599 structural Zn binding site [ion binding]; other site 336982005600 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982005601 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 336982005602 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 336982005603 putative active site [active] 336982005604 catalytic triad [active] 336982005605 putative dimer interface [polypeptide binding]; other site 336982005606 short chain dehydrogenase; Provisional; Region: PRK06197 336982005607 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 336982005608 putative NAD(P) binding site [chemical binding]; other site 336982005609 active site 336982005610 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 336982005611 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982005612 Cytochrome P450; Region: p450; cl12078 336982005613 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 336982005614 Cytochrome P450; Region: p450; cl12078 336982005615 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 336982005616 Domain of unknown function DUF; Region: DUF202; cl09954 336982005617 Domain of unknown function DUF; Region: DUF202; cl09954 336982005618 Cytochrome P450; Region: p450; cl12078 336982005619 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 336982005620 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 336982005621 putative active site [active] 336982005622 catalytic site [active] 336982005623 putative metal binding site [ion binding]; other site 336982005624 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 336982005625 FAD binding domain; Region: FAD_binding_4; pfam01565 336982005626 Phosphate transporter family; Region: PHO4; cl00396 336982005627 Phosphate transporter family; Region: PHO4; cl00396 336982005628 Transcriptional regulator [Transcription]; Region: LysR; COG0583 336982005629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982005630 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982005631 dimerization interface [polypeptide binding]; other site 336982005632 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982005633 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982005634 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982005635 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982005636 Condensation domain; Region: Condensation; cl09290 336982005637 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 336982005638 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 336982005639 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 336982005640 CDP-diacylglycerol pyrophosphatase cdh; Mapped to H37Rv Rv2289 336982005641 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 336982005642 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 336982005643 active site residue [active] 336982005644 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 336982005645 active site residue [active] 336982005646 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 336982005647 aspartate aminotransferase; Provisional; Region: PRK08361 336982005648 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982005649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982005650 homodimer interface [polypeptide binding]; other site 336982005651 catalytic residue [active] 336982005652 Uncharacterised protein family (UPF0167); Region: UPF0167; cl01252 336982005653 haloalkane dehalogenase; Provisional; Region: PRK00870 336982005654 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 336982005655 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 336982005656 active site 336982005657 catalytic tetrad [active] 336982005658 heat shock protein 90; Provisional; Region: PRK05218 336982005659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 336982005660 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982005661 Cutinase; Region: Cutinase; pfam01083 336982005662 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 336982005663 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 336982005664 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 336982005665 Condensation domain; Region: Condensation; cl09290 336982005666 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 336982005667 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982005668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 336982005669 Protein of unknown function (DUF433); Region: DUF433; cl01030 336982005670 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 336982005671 DNA binding site [nucleotide binding] 336982005672 active site 336982005673 Int/Topo IB signature motif; other site 336982005674 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 336982005675 DNA binding residues [nucleotide binding] 336982005676 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 336982005677 Uncharacterized conserved protein [Function unknown]; Region: COG2128 336982005678 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 336982005679 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 336982005680 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 336982005681 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 336982005682 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 336982005683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982005684 putative PBP binding loops; other site 336982005685 ABC-ATPase subunit interface; other site 336982005686 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 336982005687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982005688 dimer interface [polypeptide binding]; other site 336982005689 conserved gate region; other site 336982005690 putative PBP binding loops; other site 336982005691 ABC-ATPase subunit interface; other site 336982005692 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982005693 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 336982005694 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 336982005695 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 336982005696 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 336982005697 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982005698 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982005699 catalytic residue [active] 336982005700 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982005701 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982005702 Amidinotransferase; Region: Amidinotransf; cl12043 336982005703 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 336982005704 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 336982005705 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982005706 Cobalt transport protein; Region: CbiQ; cl00463 336982005707 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 336982005708 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 336982005709 Walker A/P-loop; other site 336982005710 ATP binding site [chemical binding]; other site 336982005711 Q-loop/lid; other site 336982005712 ABC transporter signature motif; other site 336982005713 Walker B; other site 336982005714 D-loop; other site 336982005715 H-loop/switch region; other site 336982005716 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 336982005717 Walker A/P-loop; other site 336982005718 ATP binding site [chemical binding]; other site 336982005719 Q-loop/lid; other site 336982005720 ABC transporter signature motif; other site 336982005721 Walker B; other site 336982005722 D-loop; other site 336982005723 H-loop/switch region; other site 336982005724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982005725 PE family; Region: PE; pfam00934 336982005726 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 336982005727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982005728 putative substrate translocation pore; other site 336982005729 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 336982005730 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 336982005731 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 336982005732 malate dehydrogenase; Provisional; Region: PRK13529 336982005733 Malic enzyme, N-terminal domain; Region: malic; pfam00390 336982005734 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 336982005735 NAD(P) binding site [chemical binding]; other site 336982005736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982005737 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982005738 putative substrate translocation pore; other site 336982005739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982005740 putative substrate translocation pore; other site 336982005741 cysteine synthases; Region: cysKM; TIGR01136 336982005742 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 336982005743 dimer interface [polypeptide binding]; other site 336982005744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982005745 catalytic residue [active] 336982005746 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 336982005747 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 336982005748 trimer interface [polypeptide binding]; other site 336982005749 active site 336982005750 substrate binding site [chemical binding]; other site 336982005751 CoA binding site [chemical binding]; other site 336982005752 hypothetical protein; Provisional; Region: PRK14851 336982005753 hypothetical protein; Validated; Region: PRK08223 336982005754 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 336982005755 ATP binding site [chemical binding]; other site 336982005756 substrate interface [chemical binding]; other site 336982005757 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982005758 PE family; Region: PE; pfam00934 336982005759 DNA primase; Validated; Region: dnaG; PRK05667 336982005760 CHC2 zinc finger; Region: zf-CHC2; cl02597 336982005761 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 336982005762 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 336982005763 active site 336982005764 metal binding site [ion binding]; metal-binding site 336982005765 interdomain interaction site; other site 336982005766 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 336982005767 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 336982005768 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 336982005769 Domain of unknown function (DUF477); Region: DUF477; cl01535 336982005770 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982005771 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982005772 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 336982005773 Phosphoesterase family; Region: Phosphoesterase; cl10627 336982005774 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 336982005775 Phosphoesterase family; Region: Phosphoesterase; cl10627 336982005776 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 336982005777 Phosphoesterase family; Region: Phosphoesterase; cl10627 336982005778 PPE family; Region: PPE; pfam00823 336982005779 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982005780 putative transposase OrfB; Reviewed; Region: PHA02517 336982005781 Integrase core domain; Region: rve; cl01316 336982005782 PPE family; Region: PPE; pfam00823 336982005783 Sec24-related protein; Provisional; Region: PTZ00395 336982005784 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982005785 putative transposase OrfB; Reviewed; Region: PHA02517 336982005786 Integrase core domain; Region: rve; cl01316 336982005787 PPE family; Region: PPE; pfam00823 336982005788 PPE family; Region: PPE; pfam00823 336982005789 glycyl-tRNA synthetase; Provisional; Region: PRK04173 336982005790 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 336982005791 active site 336982005792 motif 2; other site 336982005793 motif 3; other site 336982005794 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 336982005795 anticodon binding site; other site 336982005796 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982005797 dimerization interface [polypeptide binding]; other site 336982005798 putative DNA binding site [nucleotide binding]; other site 336982005799 putative Zn2+ binding site [ion binding]; other site 336982005800 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 336982005801 metal binding site 2 [ion binding]; metal-binding site 336982005802 putative DNA binding helix; other site 336982005803 metal binding site 1 [ion binding]; metal-binding site 336982005804 dimer interface [polypeptide binding]; other site 336982005805 structural Zn2+ binding site [ion binding]; other site 336982005806 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 336982005807 catalytic residue [active] 336982005808 putative FPP diphosphate binding site; other site 336982005809 putative FPP binding hydrophobic cleft; other site 336982005810 dimer interface [polypeptide binding]; other site 336982005811 putative IPP diphosphate binding site; other site 336982005812 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 336982005813 Recombination protein O N terminal; Region: RecO_N; pfam11967 336982005814 Recombination protein O C terminal; Region: RecO_C; pfam02565 336982005815 amidase; Provisional; Region: PRK06061 336982005816 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 336982005817 GTPase Era; Reviewed; Region: era; PRK00089 336982005818 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 336982005819 G1 box; other site 336982005820 GTP/Mg2+ binding site [chemical binding]; other site 336982005821 Switch I region; other site 336982005822 G2 box; other site 336982005823 Switch II region; other site 336982005824 G3 box; other site 336982005825 G4 box; other site 336982005826 G5 box; other site 336982005827 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 336982005828 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 336982005829 Domain of unknown function DUF21; Region: DUF21; pfam01595 336982005830 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 336982005831 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 336982005832 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 336982005833 PhoH-like protein; Region: PhoH; cl12134 336982005834 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 336982005835 PE family; Region: PE; pfam00934 336982005836 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 336982005837 chaperone protein DnaJ; Provisional; Region: PRK14278 336982005838 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 336982005839 HSP70 interaction site [polypeptide binding]; other site 336982005840 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 336982005841 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 336982005842 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 336982005843 HrcA protein C terminal domain; Region: HrcA; pfam01628 336982005844 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 336982005845 MbtH-like protein; Region: MbtH; cl01279 336982005846 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 336982005847 Condensation domain; Region: Condensation; cl09290 336982005848 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 336982005849 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982005850 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982005851 Condensation domain; Region: Condensation; cl09290 336982005852 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 336982005853 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 336982005854 Condensation domain; Region: Condensation; cl09290 336982005855 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982005856 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982005857 Condensation domain; Region: Condensation; cl09290 336982005858 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 336982005859 peptide synthase; Validated; Region: PRK05691 336982005860 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982005861 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 336982005862 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982005863 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 336982005864 NADP binding site [chemical binding]; other site 336982005865 active site 336982005866 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982005867 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982005868 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 336982005869 active site 336982005870 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982005871 Condensation domain; Region: Condensation; cl09290 336982005872 Nonribosomal peptide synthase; Region: NRPS; pfam08415 336982005873 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 336982005874 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982005875 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982005876 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982005877 Thioesterase domain; Region: Thioesterase; pfam00975 336982005878 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 336982005879 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982005880 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 336982005881 salicylate synthase MbtI; Reviewed; Region: PRK07912 336982005882 chorismate binding enzyme; Region: Chorismate_bind; cl10555 336982005883 Domain of unknown function (DUF897); Region: DUF897; cl01312 336982005884 coproporphyrinogen III oxidase; Validated; Region: PRK05628 336982005885 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 336982005886 HemN C-terminal region; Region: HemN_C; pfam06969 336982005887 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 336982005888 conserved hypothetical protein; Mapped to H37Rv Rv2390c; interrupted by transposases 336982005889 putative transposase OrfB; Reviewed; Region: PHA02517 336982005890 Integrase core domain; Region: rve; cl01316 336982005891 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982005892 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 336982005893 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 336982005894 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 336982005895 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 336982005896 Active Sites [active] 336982005897 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 336982005898 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 336982005899 putative active site [active] 336982005900 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_C; cd03414 336982005901 putative active site [active] 336982005902 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 336982005903 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 336982005904 OPT oligopeptide transporter protein; Region: OPT; cl14607 336982005905 putative oligopeptide transporter, OPT family; Region: TIGR00733 336982005906 PE family; Region: PE; pfam00934 336982005907 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296 336982005908 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 336982005909 Walker A/P-loop; other site 336982005910 ATP binding site [chemical binding]; other site 336982005911 Q-loop/lid; other site 336982005912 ABC transporter signature motif; other site 336982005913 Walker B; other site 336982005914 D-loop; other site 336982005915 H-loop/switch region; other site 336982005916 sulfate transport protein; Provisional; Region: cysT; CHL00187 336982005917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982005918 dimer interface [polypeptide binding]; other site 336982005919 conserved gate region; other site 336982005920 putative PBP binding loops; other site 336982005921 ABC-ATPase subunit interface; other site 336982005922 sulfate transport protein; Provisional; Region: cysT; CHL00187 336982005923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982005924 dimer interface [polypeptide binding]; other site 336982005925 conserved gate region; other site 336982005926 putative PBP binding loops; other site 336982005927 ABC-ATPase subunit interface; other site 336982005928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982005929 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 336982005930 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 336982005931 GTP-binding protein LepA; Provisional; Region: PRK05433 336982005932 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 336982005933 G1 box; other site 336982005934 putative GEF interaction site [polypeptide binding]; other site 336982005935 GTP/Mg2+ binding site [chemical binding]; other site 336982005936 Switch I region; other site 336982005937 G2 box; other site 336982005938 G3 box; other site 336982005939 Switch II region; other site 336982005940 G4 box; other site 336982005941 G5 box; other site 336982005942 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 336982005943 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 336982005944 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 336982005945 PemK-like protein; Region: PemK; cl00995 336982005946 FOG: CBS domain [General function prediction only]; Region: COG0517 336982005947 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 336982005948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982005949 PE family; Region: PE; pfam00934 336982005950 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 336982005951 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 336982005952 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 336982005953 Uncharacterized conserved protein [Function unknown]; Region: COG2308 336982005954 Domain of unknown function (DUF404); Region: DUF404; pfam04169 336982005955 Domain of unknown function (DUF407); Region: DUF407; pfam04174 336982005956 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 336982005957 hypothetical protein; Reviewed; Region: PRK07914 336982005958 Competence protein; Region: Competence; cl00471 336982005959 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 336982005960 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 336982005961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 336982005962 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 336982005963 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 336982005964 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 336982005965 active site 336982005966 catalytic triad [active] 336982005967 oxyanion hole [active] 336982005968 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982005969 catalytic core [active] 336982005970 Domain of unknown function DUF143; Region: DUF143; cl00519 336982005971 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 336982005972 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 336982005973 active site 336982005974 (T/H)XGH motif; other site 336982005975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982005976 S-adenosylmethionine binding site [chemical binding]; other site 336982005977 Transposase; Region: DEDD_Tnp_IS110; pfam01548 336982005978 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 336982005979 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 336982005980 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 336982005981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982005982 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 336982005983 Walker A motif; other site 336982005984 ATP binding site [chemical binding]; other site 336982005985 Walker B motif; other site 336982005986 arginine finger; other site 336982005987 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 336982005988 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 336982005989 putative catalytic cysteine [active] 336982005990 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 336982005991 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 336982005992 dimer interface [polypeptide binding]; other site 336982005993 decamer (pentamer of dimers) interface [polypeptide binding]; other site 336982005994 catalytic triad [active] 336982005995 peroxidatic and resolving cysteines [active] 336982005996 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 336982005997 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 336982005998 PPE family; Region: PPE; pfam00823 336982005999 PE family; Region: PE; pfam00934 336982006000 Mechanosensitive ion channel; Region: MS_channel; pfam00924 336982006001 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982006002 ligand binding site [chemical binding]; other site 336982006003 flexible hinge region; other site 336982006004 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 336982006005 dimerization interface [polypeptide binding]; other site 336982006006 cyclase homology domain; Region: CHD; cd07302 336982006007 nucleotidyl binding site; other site 336982006008 metal binding site [ion binding]; metal-binding site 336982006009 dimer interface [polypeptide binding]; other site 336982006010 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 336982006011 substrate binding site [chemical binding]; other site 336982006012 ATP binding site [chemical binding]; other site 336982006013 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 336982006014 NAD synthetase; Reviewed; Region: nadE; PRK02628 336982006015 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 336982006016 multimer interface [polypeptide binding]; other site 336982006017 active site 336982006018 catalytic triad [active] 336982006019 protein interface 1 [polypeptide binding]; other site 336982006020 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 336982006021 homodimer interface [polypeptide binding]; other site 336982006022 NAD binding pocket [chemical binding]; other site 336982006023 ATP binding pocket [chemical binding]; other site 336982006024 Mg binding site [ion binding]; other site 336982006025 active-site loop [active] 336982006026 gamma-glutamyl kinase; Provisional; Region: PRK05429 336982006027 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 336982006028 nucleotide binding site [chemical binding]; other site 336982006029 homotetrameric interface [polypeptide binding]; other site 336982006030 putative phosphate binding site [ion binding]; other site 336982006031 putative allosteric binding site; other site 336982006032 PUA domain; Region: PUA; cl00607 336982006033 GTPase CgtA; Reviewed; Region: obgE; PRK12296 336982006034 GTP1/OBG; Region: GTP1_OBG; pfam01018 336982006035 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 336982006036 G1 box; other site 336982006037 GTP/Mg2+ binding site [chemical binding]; other site 336982006038 Switch I region; other site 336982006039 G2 box; other site 336982006040 G3 box; other site 336982006041 Switch II region; other site 336982006042 G4 box; other site 336982006043 G5 box; other site 336982006044 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 336982006045 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 336982006046 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 336982006047 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 336982006048 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 336982006049 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 336982006050 homodimer interface [polypeptide binding]; other site 336982006051 oligonucleotide binding site [chemical binding]; other site 336982006052 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 336982006053 active site 336982006054 multimer interface [polypeptide binding]; other site 336982006055 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 336982006056 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 336982006057 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 336982006058 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982006059 active site 336982006060 HIGH motif; other site 336982006061 nucleotide binding site [chemical binding]; other site 336982006062 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 336982006063 active site 336982006064 KMSKS motif; other site 336982006065 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 336982006066 tRNA binding surface [nucleotide binding]; other site 336982006067 anticodon binding site; other site 336982006068 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 336982006069 Uncharacterized conserved protein [Function unknown]; Region: COG3268 336982006070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982006071 NAD(P) binding pocket [chemical binding]; other site 336982006072 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 336982006073 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 336982006074 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 336982006075 GTP binding site [chemical binding]; other site 336982006076 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 336982006077 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 336982006078 TPP-binding site [chemical binding]; other site 336982006079 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 336982006080 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 336982006081 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 336982006082 dimer interface [polypeptide binding]; other site 336982006083 PYR/PP interface [polypeptide binding]; other site 336982006084 TPP binding site [chemical binding]; other site 336982006085 substrate binding site [chemical binding]; other site 336982006086 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982006087 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 336982006088 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 336982006089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982006090 Walker A motif; other site 336982006091 ATP binding site [chemical binding]; other site 336982006092 Walker B motif; other site 336982006093 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 336982006094 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 336982006095 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 336982006096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982006097 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982006098 putative substrate translocation pore; other site 336982006099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982006100 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 336982006101 oligomer interface [polypeptide binding]; other site 336982006102 active site residues [active] 336982006103 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 336982006104 oligomer interface [polypeptide binding]; other site 336982006105 active site residues [active] 336982006106 trigger factor; Provisional; Region: tig; PRK01490 336982006107 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 336982006108 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 336982006109 Beta-lactamase; Region: Beta-lactamase; cl01009 336982006110 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 336982006111 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 336982006112 putative DNA binding site [nucleotide binding]; other site 336982006113 catalytic residue [active] 336982006114 putative H2TH interface [polypeptide binding]; other site 336982006115 putative catalytic residues [active] 336982006116 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 336982006117 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 336982006118 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 336982006119 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 336982006120 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 336982006121 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 336982006122 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 336982006123 Zn binding site [ion binding]; other site 336982006124 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 336982006125 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982006126 active site 336982006127 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 336982006128 apolar tunnel; other site 336982006129 heme binding site [chemical binding]; other site 336982006130 dimerization interface [polypeptide binding]; other site 336982006131 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 336982006132 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 336982006133 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 336982006134 active site 336982006135 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 336982006136 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 336982006137 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982006138 Walker A/P-loop; other site 336982006139 ATP binding site [chemical binding]; other site 336982006140 Q-loop/lid; other site 336982006141 ABC transporter signature motif; other site 336982006142 Walker B; other site 336982006143 D-loop; other site 336982006144 H-loop/switch region; other site 336982006145 ABC transporter; Region: ABC_tran_2; pfam12848 336982006146 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 336982006147 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 336982006148 dimer interface [polypeptide binding]; other site 336982006149 ssDNA binding site [nucleotide binding]; other site 336982006150 tetramer (dimer of dimers) interface [polypeptide binding]; other site 336982006151 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 336982006152 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 336982006153 putative acyl-acceptor binding pocket; other site 336982006154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982006155 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 336982006156 putative acyl-acceptor binding pocket; other site 336982006157 Condensation domain; Region: Condensation; cl09290 336982006158 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982006159 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 336982006160 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982006161 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982006162 enoyl-CoA hydratase; Provisional; Region: PRK05870 336982006163 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982006164 substrate binding site [chemical binding]; other site 336982006165 oxyanion hole (OAH) forming residues; other site 336982006166 trimer interface [polypeptide binding]; other site 336982006167 PE family; Region: PE; pfam00934 336982006168 cyclase homology domain; Region: CHD; cd07302 336982006169 nucleotidyl binding site; other site 336982006170 metal binding site [ion binding]; metal-binding site 336982006171 dimer interface [polypeptide binding]; other site 336982006172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982006173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 336982006174 DNA binding residues [nucleotide binding] 336982006175 dimerization interface [polypeptide binding]; other site 336982006176 PE family; Region: PE; pfam00934 336982006177 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 336982006178 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cl00358 336982006179 active site 336982006180 dimerization interface [polypeptide binding]; other site 336982006181 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982006182 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 336982006183 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 336982006184 E3 interaction surface; other site 336982006185 lipoyl attachment site [posttranslational modification]; other site 336982006186 e3 binding domain; Region: E3_binding; pfam02817 336982006187 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 336982006188 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 336982006189 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 336982006190 alpha subunit interface [polypeptide binding]; other site 336982006191 TPP binding site [chemical binding]; other site 336982006192 heterodimer interface [polypeptide binding]; other site 336982006193 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 336982006194 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 336982006195 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 336982006196 tetramer interface [polypeptide binding]; other site 336982006197 TPP-binding site [chemical binding]; other site 336982006198 heterodimer interface [polypeptide binding]; other site 336982006199 phosphorylation loop region [posttranslational modification] 336982006200 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 336982006201 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 336982006202 putative active site [active] 336982006203 putative catalytic site [active] 336982006204 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982006205 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982006206 active site 336982006207 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 336982006208 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 336982006209 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 336982006210 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 336982006211 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 336982006212 carboxyltransferase (CT) interaction site; other site 336982006213 biotinylation site [posttranslational modification]; other site 336982006214 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 336982006215 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 336982006216 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 336982006217 Coenzyme A transferase; Region: CoA_trans; cl00773 336982006218 Coenzyme A transferase; Region: CoA_trans; cl00773 336982006219 AMP-binding domain protein; Validated; Region: PRK08315 336982006220 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982006221 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982006222 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 336982006223 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 336982006224 classical (c) SDRs; Region: SDR_c; cd05233 336982006225 NAD(P) binding site [chemical binding]; other site 336982006226 active site 336982006227 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 336982006228 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 336982006229 putative active site [active] 336982006230 putative substrate binding site [chemical binding]; other site 336982006231 catalytic site [active] 336982006232 dimer interface [polypeptide binding]; other site 336982006233 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982006234 MULE transposase domain; Region: MULE; pfam10551 336982006235 PIN domain; Region: PIN; cl09128 336982006236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 336982006237 Domain of unknown function (DUF955); Region: DUF955; cl01076 336982006238 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 336982006239 PE family; Region: PE; pfam00934 336982006240 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 336982006241 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 336982006242 catalytic triad [active] 336982006243 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 336982006244 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 336982006245 active site 336982006246 metal binding site [ion binding]; metal-binding site 336982006247 dimer interface [polypeptide binding]; other site 336982006248 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 336982006249 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982006250 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 336982006251 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 336982006252 phosphate binding site [ion binding]; other site 336982006253 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 336982006254 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 336982006255 putative active site [active] 336982006256 putative catalytic site [active] 336982006257 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982006258 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 336982006259 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 336982006260 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 336982006261 putative NAD(P) binding site [chemical binding]; other site 336982006262 active site 336982006263 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 336982006264 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 336982006265 active site 336982006266 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 336982006267 active site 336982006268 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982006269 putative active site [active] 336982006270 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 336982006271 Restriction endonuclease; Region: Mrr_cat; cl00747 336982006272 ERCC4 domain; Region: ERCC4; pfam02732 336982006273 Lsr2; Region: Lsr2; pfam11774 336982006274 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982006275 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 336982006276 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982006277 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982006278 catalytic residue [active] 336982006279 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 336982006280 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 336982006281 putative RNA binding site [nucleotide binding]; other site 336982006282 elongation factor P; Validated; Region: PRK00529 336982006283 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 336982006284 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 336982006285 RNA binding site [nucleotide binding]; other site 336982006286 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 336982006287 RNA binding site [nucleotide binding]; other site 336982006288 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 336982006289 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 336982006290 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 336982006291 active site 336982006292 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 336982006293 trimer interface [polypeptide binding]; other site 336982006294 active site 336982006295 dimer interface [polypeptide binding]; other site 336982006296 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 336982006297 active site 336982006298 dimer interface [polypeptide binding]; other site 336982006299 metal binding site [ion binding]; metal-binding site 336982006300 shikimate kinase; Reviewed; Region: aroK; PRK00131 336982006301 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 336982006302 ADP binding site [chemical binding]; other site 336982006303 magnesium binding site [ion binding]; other site 336982006304 putative shikimate binding site; other site 336982006305 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 336982006306 Tetramer interface [polypeptide binding]; other site 336982006307 Active site [active] 336982006308 FMN-binding site [chemical binding]; other site 336982006309 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 336982006310 digalactosyldiacylglycerol synthase; Region: PLN02846 336982006311 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 336982006312 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982006313 putative active site [active] 336982006314 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 336982006315 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 336982006316 oligomeric interface; other site 336982006317 putative active site [active] 336982006318 homodimer interface [polypeptide binding]; other site 336982006319 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982006320 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl10494 336982006321 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 336982006322 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 336982006323 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 336982006324 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 336982006325 NAD(P) binding site [chemical binding]; other site 336982006326 shikimate binding site; other site 336982006327 YceG-like family; Region: YceG; pfam02618 336982006328 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 336982006329 dimerization interface [polypeptide binding]; other site 336982006330 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 336982006331 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 336982006332 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 336982006333 motif 1; other site 336982006334 active site 336982006335 motif 2; other site 336982006336 motif 3; other site 336982006337 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 336982006338 DHHA1 domain; Region: DHHA1; pfam02272 336982006339 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 336982006340 recombination factor protein RarA; Reviewed; Region: PRK13342 336982006341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982006342 Walker A motif; other site 336982006343 ATP binding site [chemical binding]; other site 336982006344 Walker B motif; other site 336982006345 arginine finger; other site 336982006346 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 336982006347 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 336982006348 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 336982006349 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 336982006350 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 336982006351 Walker A/P-loop; other site 336982006352 ATP binding site [chemical binding]; other site 336982006353 Q-loop/lid; other site 336982006354 ABC transporter signature motif; other site 336982006355 Walker B; other site 336982006356 D-loop; other site 336982006357 H-loop/switch region; other site 336982006358 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982006359 ligand binding site [chemical binding]; other site 336982006360 flexible hinge region; other site 336982006361 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982006362 ligand binding site [chemical binding]; other site 336982006363 flexible hinge region; other site 336982006364 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 336982006365 active site 336982006366 nucleophile elbow; other site 336982006367 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 336982006368 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 336982006369 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 336982006370 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 336982006371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 336982006372 Uncharacterized conserved protein [Function unknown]; Region: COG2308 336982006373 Domain of unknown function (DUF404); Region: DUF404; pfam04169 336982006374 Domain of unknown function (DUF407); Region: DUF407; pfam04174 336982006375 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 336982006376 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl09206 336982006377 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 336982006378 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 336982006379 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 336982006380 Protein of unknown function (DUF419); Region: DUF419; cl09948 336982006381 Predicted membrane protein [Function unknown]; Region: COG4129 336982006382 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 336982006383 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 336982006384 dimer interface [polypeptide binding]; other site 336982006385 anticodon binding site; other site 336982006386 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 336982006387 homodimer interface [polypeptide binding]; other site 336982006388 motif 1; other site 336982006389 active site 336982006390 motif 2; other site 336982006391 GAD domain; Region: GAD; pfam02938 336982006392 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 336982006393 active site 336982006394 motif 3; other site 336982006395 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 336982006396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982006397 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 336982006398 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 336982006399 putative hydrophobic ligand binding site [chemical binding]; other site 336982006400 protein interface [polypeptide binding]; other site 336982006401 gate; other site 336982006402 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 336982006403 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 336982006404 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 336982006405 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 336982006406 active site 336982006407 metal binding site [ion binding]; metal-binding site 336982006408 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 336982006409 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 336982006410 haloalkane dehalogenase; Provisional; Region: PRK03592 336982006411 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 336982006412 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 336982006413 dimer interface [polypeptide binding]; other site 336982006414 motif 1; other site 336982006415 active site 336982006416 motif 2; other site 336982006417 motif 3; other site 336982006418 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 336982006419 anticodon binding site; other site 336982006420 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982006421 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 336982006422 active site 336982006423 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 336982006424 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 336982006425 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 336982006426 synthetase active site [active] 336982006427 NTP binding site [chemical binding]; other site 336982006428 metal binding site [ion binding]; metal-binding site 336982006429 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 336982006430 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 336982006431 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 336982006432 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 336982006433 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 336982006434 Protein export membrane protein; Region: SecD_SecF; cl14618 336982006435 protein-export membrane protein SecD; Region: secD; TIGR01129 336982006436 Protein export membrane protein; Region: SecD_SecF; cl14618 336982006437 Preprotein translocase subunit; Region: YajC; cl00806 336982006438 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 336982006439 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 336982006440 inhibitor-cofactor binding pocket; inhibition site 336982006441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982006442 catalytic residue [active] 336982006443 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 336982006444 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 336982006445 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 336982006446 putative NAD(P) binding site [chemical binding]; other site 336982006447 active site 336982006448 putative substrate binding site [chemical binding]; other site 336982006449 PE family; Region: PE; pfam00934 336982006450 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 336982006451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982006452 Walker A motif; other site 336982006453 ATP binding site [chemical binding]; other site 336982006454 Walker B motif; other site 336982006455 arginine finger; other site 336982006456 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 336982006457 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 336982006458 RuvA N terminal domain; Region: RuvA_N; pfam01330 336982006459 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 336982006460 active site 336982006461 putative DNA-binding cleft [nucleotide binding]; other site 336982006462 dimer interface [polypeptide binding]; other site 336982006463 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982006464 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 336982006465 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 336982006466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982006467 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 336982006468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982006469 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982006470 Domain of unknown function DUF28; Region: DUF28; cl00361 336982006471 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 336982006472 predicted active site [active] 336982006473 catalytic triad [active] 336982006474 acyl-CoA thioesterase II; Region: tesB; TIGR00189 336982006475 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 336982006476 active site 336982006477 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 336982006478 catalytic triad [active] 336982006479 dimer interface [polypeptide binding]; other site 336982006480 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 336982006481 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 336982006482 active site 336982006483 multimer interface [polypeptide binding]; other site 336982006484 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 336982006485 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 336982006486 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 336982006487 PPE family; Region: PPE; pfam00823 336982006488 PE-PPE domain; Region: PE-PPE; pfam08237 336982006489 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 336982006490 nudix motif; other site 336982006491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 336982006492 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 336982006493 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 336982006494 putative acyl-acceptor binding pocket; other site 336982006495 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 336982006496 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 336982006497 nucleotide binding site/active site [active] 336982006498 HIT family signature motif; other site 336982006499 catalytic residue [active] 336982006500 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 336982006501 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 336982006502 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 336982006503 active site 336982006504 dimer interface [polypeptide binding]; other site 336982006505 motif 1; other site 336982006506 motif 2; other site 336982006507 motif 3; other site 336982006508 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 336982006509 anticodon binding site; other site 336982006510 PE family; Region: PE; pfam00934 336982006511 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 336982006512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982006513 Predicted transcriptional regulator [Transcription]; Region: COG2345 336982006514 Cupin domain; Region: Cupin_2; cl09118 336982006515 Predicted transcriptional regulator [Transcription]; Region: COG2345 336982006516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982006517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982006518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982006519 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982006520 Ligand Binding Site [chemical binding]; other site 336982006521 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982006522 Ligand Binding Site [chemical binding]; other site 336982006523 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982006524 Ligand Binding Site [chemical binding]; other site 336982006525 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 336982006526 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 336982006527 active site 336982006528 putative substrate binding region [chemical binding]; other site 336982006529 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC...; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 336982006530 FOG: CBS domain [General function prediction only]; Region: COG0517 336982006531 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 336982006532 peptide chain release factor eRF/aRF, subunit 1; Region: eRF; TIGR00108 336982006533 Archease protein family (DUF101/UPF0211); Region: Archease; cl00606 336982006534 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 336982006535 hypothetical protein; Reviewed; Region: PRK09588 336982006536 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 336982006537 PE family; Region: PE; pfam00934 336982006538 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 336982006539 P-loop motif; other site 336982006540 ATP binding site [chemical binding]; other site 336982006541 Chloramphenicol (Cm) binding site [chemical binding]; other site 336982006542 catalytic residue [active] 336982006543 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 336982006544 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 336982006545 anti sigma factor interaction site; other site 336982006546 regulatory phosphorylation site [posttranslational modification]; other site 336982006547 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 336982006548 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982006549 putative DNA binding site [nucleotide binding]; other site 336982006550 putative Zn2+ binding site [ion binding]; other site 336982006551 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 336982006552 putative metal binding site [ion binding]; other site 336982006553 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982006554 dimerization interface [polypeptide binding]; other site 336982006555 putative DNA binding site [nucleotide binding]; other site 336982006556 putative Zn2+ binding site [ion binding]; other site 336982006557 Membrane transport protein; Region: Mem_trans; cl09117 336982006558 Low molecular weight phosphatase family; Region: LMWPc; cd00115 336982006559 Active site [active] 336982006560 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 336982006561 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 336982006562 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 336982006563 DNA binding site [nucleotide binding] 336982006564 Int/Topo IB signature motif; other site 336982006565 active site 336982006566 ParB-like partition proteins; Region: parB_part; TIGR00180 336982006567 ParB-like nuclease domain; Region: ParBc; cl02129 336982006568 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 336982006569 Phage capsid family; Region: Phage_capsid; pfam05065 336982006570 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 336982006571 Phage terminase, small subunit; Region: Terminase_4; cl01525 336982006572 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 336982006573 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 336982006574 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 336982006575 Phage integrase family; Region: Phage_integrase; pfam00589 336982006576 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 336982006577 Int/Topo IB signature motif; other site 336982006578 active site 336982006579 DNA binding site [nucleotide binding] 336982006580 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982006581 MULE transposase domain; Region: MULE; pfam10551 336982006582 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 336982006583 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 336982006584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982006585 Coenzyme A binding pocket [chemical binding]; other site 336982006586 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 336982006587 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 336982006588 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 336982006589 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982006590 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 336982006591 SelR domain; Region: SelR; cl00369 336982006592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982006593 S-adenosylmethionine binding site [chemical binding]; other site 336982006594 Chlorite dismutase; Region: Chlor_dismutase; cl01280 336982006595 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 336982006596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982006597 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 336982006598 substrate binding site [chemical binding]; other site 336982006599 active site 336982006600 enoyl-CoA hydratase; Provisional; Region: PRK07327 336982006601 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982006602 substrate binding site [chemical binding]; other site 336982006603 oxyanion hole (OAH) forming residues; other site 336982006604 trimer interface [polypeptide binding]; other site 336982006605 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 336982006606 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 336982006607 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 336982006608 putative active site [active] 336982006609 catalytic site [active] 336982006610 putative substrate binding site [chemical binding]; other site 336982006611 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 336982006612 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 336982006613 TPP-binding site; other site 336982006614 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 336982006615 PYR/PP interface [polypeptide binding]; other site 336982006616 dimer interface [polypeptide binding]; other site 336982006617 TPP binding site [chemical binding]; other site 336982006618 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 336982006619 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 336982006620 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 336982006621 transmembrane helices; other site 336982006622 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 336982006623 transmembrane helices; other site 336982006624 Citrate transporter; Region: CitMHS; pfam03600 336982006625 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 336982006626 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 336982006627 Walker A/P-loop; other site 336982006628 ATP binding site [chemical binding]; other site 336982006629 Q-loop/lid; other site 336982006630 ABC transporter signature motif; other site 336982006631 Walker B; other site 336982006632 D-loop; other site 336982006633 H-loop/switch region; other site 336982006634 TRAM domain; Region: TRAM; cl01282 336982006635 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 336982006636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982006637 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 336982006638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982006639 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 336982006640 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 336982006641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982006642 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 336982006643 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 336982006644 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 336982006645 generic binding surface II; other site 336982006646 ssDNA binding site; other site 336982006647 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 336982006648 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 336982006649 trimer interface [polypeptide binding]; other site 336982006650 active site 336982006651 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 336982006652 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 336982006653 active site 336982006654 dimerization interface [polypeptide binding]; other site 336982006655 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 336982006656 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 336982006657 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982006658 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 336982006659 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 336982006660 DNA binding residues [nucleotide binding] 336982006661 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 336982006662 homotrimer interaction site [polypeptide binding]; other site 336982006663 putative active site [active] 336982006664 Protein of unknown function (DUF952); Region: DUF952; cl01393 336982006665 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 336982006666 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 336982006667 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 336982006668 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 336982006669 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 336982006670 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982006671 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 336982006672 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 336982006673 DNA binding residues [nucleotide binding] 336982006674 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 336982006675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982006676 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 336982006677 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 336982006678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982006679 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982006680 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 336982006681 PAC2 family; Region: PAC2; cl00847 336982006682 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982006683 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982006684 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 336982006685 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 336982006686 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 336982006687 heme-binding site [chemical binding]; other site 336982006688 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 336982006689 ATP cone domain; Region: ATP-cone; pfam03477 336982006690 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 336982006691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982006692 LexA repressor; Validated; Region: PRK00215 336982006693 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 336982006694 Catalytic site [active] 336982006695 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 336982006696 LGFP repeat; Region: LGFP; pfam08310 336982006697 LGFP repeat; Region: LGFP; pfam08310 336982006698 LGFP repeat; Region: LGFP; pfam08310 336982006699 LGFP repeat; Region: LGFP; pfam08310 336982006700 LGFP repeat; Region: LGFP; pfam08310 336982006701 Integral membrane protein TerC family; Region: TerC; cl10468 336982006702 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982006703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982006704 active site 336982006705 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 336982006706 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 336982006707 G1 box; other site 336982006708 GTP/Mg2+ binding site [chemical binding]; other site 336982006709 Switch I region; other site 336982006710 G2 box; other site 336982006711 G3 box; other site 336982006712 Switch II region; other site 336982006713 G4 box; other site 336982006714 G5 box; other site 336982006715 diaminopimelate epimerase; Region: DapF; TIGR00652 336982006716 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 336982006717 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 336982006718 IPP transferase; Region: IPPT; cl00403 336982006719 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 336982006720 active site 336982006721 metal binding site [ion binding]; metal-binding site 336982006722 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 336982006723 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 336982006724 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 336982006725 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 336982006726 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 336982006727 FeS/SAM binding site; other site 336982006728 TRAM domain; Region: TRAM; cl01282 336982006729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 336982006730 RecX family; Region: RecX; cl00936 336982006731 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 336982006732 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 336982006733 hexamer interface [polypeptide binding]; other site 336982006734 Walker A motif; other site 336982006735 ATP binding site [chemical binding]; other site 336982006736 Walker B motif; other site 336982006737 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 336982006738 thioester formation/cholesterol transfer; other site 336982006739 protein-splicing catalytic site; other site 336982006740 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982006741 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 336982006742 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 336982006743 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 336982006744 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982006745 PE family; Region: PE; pfam00934 336982006746 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 336982006747 PspA/IM30 family; Region: PspA_IM30; pfam04012 336982006748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 336982006749 non-specific DNA binding site [nucleotide binding]; other site 336982006750 salt bridge; other site 336982006751 sequence-specific DNA binding site [nucleotide binding]; other site 336982006752 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 336982006753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982006754 Coenzyme A binding pocket [chemical binding]; other site 336982006755 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982006756 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 336982006757 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 336982006758 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 336982006759 classical (c) SDRs; Region: SDR_c; cd05233 336982006760 NAD(P) binding site [chemical binding]; other site 336982006761 active site 336982006762 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982006763 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 336982006764 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982006765 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 336982006766 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 336982006767 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 336982006768 dimer interface [polypeptide binding]; other site 336982006769 active site 336982006770 catalytic residue [active] 336982006771 Thymidylate synthase complementing protein; Region: Thy1; cl03630 336982006772 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 336982006773 HsdM N-terminal domain; Region: HsdM_N; pfam12161 336982006774 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 336982006775 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 336982006776 putative active site [active] 336982006777 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 336982006778 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 336982006779 putative active site [active] 336982006780 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 336982006781 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 336982006782 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 336982006783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 336982006784 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 336982006785 folate binding site [chemical binding]; other site 336982006786 NADP+ binding site [chemical binding]; other site 336982006787 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 336982006788 dimerization interface [polypeptide binding]; other site 336982006789 active site 336982006790 Dienelactone hydrolase family; Region: DLH; pfam01738 336982006791 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 336982006792 classical (c) SDRs; Region: SDR_c; cd05233 336982006793 NAD(P) binding site [chemical binding]; other site 336982006794 active site 336982006795 PPE family; Region: PPE; pfam00823 336982006796 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982006797 PE family; Region: PE; pfam00934 336982006798 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982006799 PPE family; Region: PPE; pfam00823 336982006800 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 336982006801 dihydrodipicolinate reductase; Provisional; Region: PRK00048 336982006802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982006803 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 336982006804 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 336982006805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 336982006806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 336982006807 Coenzyme A binding pocket [chemical binding]; other site 336982006808 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 336982006809 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 336982006810 FMN-binding pocket [chemical binding]; other site 336982006811 flavin binding motif; other site 336982006812 phosphate binding motif [ion binding]; other site 336982006813 beta-alpha-beta structure motif; other site 336982006814 NAD binding pocket [chemical binding]; other site 336982006815 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982006816 catalytic loop [active] 336982006817 iron binding site [ion binding]; other site 336982006818 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 336982006819 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 336982006820 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 336982006821 hydrophobic ligand binding site; other site 336982006822 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 336982006823 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982006824 alanine dehydrogenase; Region: alaDH; TIGR00518 336982006825 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 336982006826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982006827 Nitronate monooxygenase; Region: NMO; pfam03060 336982006828 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 336982006829 FMN binding site [chemical binding]; other site 336982006830 substrate binding site [chemical binding]; other site 336982006831 putative catalytic residue [active] 336982006832 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 336982006833 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 336982006834 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 336982006835 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 336982006836 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 336982006837 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 336982006838 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 336982006839 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 336982006840 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 336982006841 putative nucleic acid binding region [nucleotide binding]; other site 336982006842 G-X-X-G motif; other site 336982006843 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 336982006844 RNA binding site [nucleotide binding]; other site 336982006845 domain interface; other site 336982006846 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 336982006847 16S/18S rRNA binding site [nucleotide binding]; other site 336982006848 S13e-L30e interaction site [polypeptide binding]; other site 336982006849 25S rRNA binding site [nucleotide binding]; other site 336982006850 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 336982006851 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 336982006852 active site 336982006853 Riboflavin kinase; Region: Flavokinase; pfam01687 336982006854 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 336982006855 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 336982006856 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111 336982006857 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 336982006858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982006859 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 336982006860 FeoA domain; Region: FeoA; cl00838 336982006861 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982006862 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982006863 active site 336982006864 lipid-transfer protein; Provisional; Region: PRK08256 336982006865 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 336982006866 active site 336982006867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 336982006868 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 336982006869 Probable transposase; Region: OrfB_IS605; pfam01385 336982006870 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 336982006871 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 336982006872 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 336982006873 catalytic residues [active] 336982006874 catalytic nucleophile [active] 336982006875 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 336982006876 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 336982006877 RNA binding site [nucleotide binding]; other site 336982006878 active site 336982006879 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 336982006880 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 336982006881 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 336982006882 active site 336982006883 metal binding site [ion binding]; metal-binding site 336982006884 Uncharacterized conserved protein [Function unknown]; Region: COG4717 336982006885 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 336982006886 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 336982006887 Predicted acyl esterases [General function prediction only]; Region: COG2936 336982006888 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 336982006889 PemK-like protein; Region: PemK; cl00995 336982006890 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 336982006891 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 336982006892 Integrase core domain; Region: rve; cl01316 336982006893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 336982006894 Integrase core domain; Region: rve; cl01316 336982006895 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 336982006896 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 336982006897 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982006898 putative transposase OrfB; Reviewed; Region: PHA02517 336982006899 Integrase core domain; Region: rve; cl01316 336982006900 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982006901 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 336982006902 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 336982006903 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 336982006904 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 336982006905 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 336982006906 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 336982006907 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 336982006908 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 336982006909 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 336982006910 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 336982006911 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 336982006912 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 336982006913 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 336982006914 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 336982006915 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 336982006916 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 336982006917 putative active site [active] 336982006918 Phd_YefM; Region: PhdYeFM; cl09153 336982006919 enoyl-CoA hydratase; Provisional; Region: PRK06190 336982006920 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982006921 substrate binding site [chemical binding]; other site 336982006922 oxyanion hole (OAH) forming residues; other site 336982006923 trimer interface [polypeptide binding]; other site 336982006924 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 336982006925 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 336982006926 Walker A/P-loop; other site 336982006927 ATP binding site [chemical binding]; other site 336982006928 Q-loop/lid; other site 336982006929 ABC transporter signature motif; other site 336982006930 Walker B; other site 336982006931 D-loop; other site 336982006932 H-loop/switch region; other site 336982006933 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 336982006934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982006935 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 336982006936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982006937 dimer interface [polypeptide binding]; other site 336982006938 conserved gate region; other site 336982006939 putative PBP binding loops; other site 336982006940 ABC-ATPase subunit interface; other site 336982006941 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 336982006942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982006943 dimer interface [polypeptide binding]; other site 336982006944 conserved gate region; other site 336982006945 putative PBP binding loops; other site 336982006946 ABC-ATPase subunit interface; other site 336982006947 putative efflux protein, MATE family; Region: matE; TIGR00797 336982006948 MatE; Region: MatE; pfam01554 336982006949 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 336982006950 DHH family; Region: DHH; pfam01368 336982006951 Ribosome-binding factor A; Region: RBFA; cl00542 336982006952 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 336982006953 translation initiation factor IF-2; Region: IF-2; TIGR00487 336982006954 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 336982006955 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 336982006956 G1 box; other site 336982006957 putative GEF interaction site [polypeptide binding]; other site 336982006958 GTP/Mg2+ binding site [chemical binding]; other site 336982006959 Switch I region; other site 336982006960 G2 box; other site 336982006961 G3 box; other site 336982006962 Switch II region; other site 336982006963 G4 box; other site 336982006964 G5 box; other site 336982006965 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 336982006966 Translation-initiation factor 2; Region: IF-2; pfam11987 336982006967 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 336982006968 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 336982006969 putative RNA binding cleft [nucleotide binding]; other site 336982006970 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 336982006971 NusA N-terminal domain; Region: NusA_N; pfam08529 336982006972 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 336982006973 RNA binding site [nucleotide binding]; other site 336982006974 homodimer interface [polypeptide binding]; other site 336982006975 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 336982006976 G-X-X-G motif; other site 336982006977 ribosome maturation protein RimP; Reviewed; Region: PRK00092 336982006978 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 336982006979 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 336982006980 Sm1 motif; other site 336982006981 D3 - B interaction site; other site 336982006982 D1 - D2 interaction site; other site 336982006983 Hfq - Hfq interaction site; other site 336982006984 RNA binding pocket [nucleotide binding]; other site 336982006985 Sm2 motif; other site 336982006986 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 336982006987 dinuclear metal binding motif [ion binding]; other site 336982006988 prolyl-tRNA synthetase; Provisional; Region: PRK09194 336982006989 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 336982006990 dimer interface [polypeptide binding]; other site 336982006991 motif 1; other site 336982006992 active site 336982006993 motif 2; other site 336982006994 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 336982006995 putative deacylase active site [active] 336982006996 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 336982006997 active site 336982006998 motif 3; other site 336982006999 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 336982007000 anticodon binding site; other site 336982007001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982007002 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 336982007003 putative substrate translocation pore; other site 336982007004 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 336982007005 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 336982007006 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 336982007007 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 336982007008 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 336982007009 catalytic triad [active] 336982007010 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 336982007011 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 336982007012 homodimer interface [polypeptide binding]; other site 336982007013 Walker A motif; other site 336982007014 ATP binding site [chemical binding]; other site 336982007015 hydroxycobalamin binding site [chemical binding]; other site 336982007016 Walker B motif; other site 336982007017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982007018 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 336982007019 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase...; Region: vWA_Magnesium_chelatase; cd01451 336982007020 metal ion-dependent adhesion site (MIDAS); other site 336982007021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 336982007022 Predicted dehydrogenase [General function prediction only]; Region: COG0579 336982007023 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 336982007024 PE family; Region: PE; pfam00934 336982007025 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 336982007026 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982007027 mycothione reductase; Reviewed; Region: PRK07846 336982007028 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982007029 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 336982007030 High-affinity nickel-transport protein; Region: NicO; cl00964 336982007031 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 336982007032 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 336982007033 classical (c) SDRs; Region: SDR_c; cd05233 336982007034 NAD(P) binding site [chemical binding]; other site 336982007035 active site 336982007036 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982007037 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 336982007038 NAD(P) binding site [chemical binding]; other site 336982007039 catalytic residues [active] 336982007040 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 336982007041 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 336982007042 catalytic triad [active] 336982007043 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 336982007044 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 336982007045 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 336982007046 active site 336982007047 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 336982007048 FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 336982007049 putative active site [active] 336982007050 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 336982007051 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 336982007052 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 336982007053 Phd_YefM; Region: PhdYeFM; cl09153 336982007054 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 336982007055 Predicted acetyltransferase [General function prediction only]; Region: COG3393 336982007056 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 336982007057 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 336982007058 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 336982007059 active site 336982007060 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 336982007061 protein binding site [polypeptide binding]; other site 336982007062 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 336982007063 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 336982007064 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 336982007065 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982007066 Fasciclin domain; Region: Fasciclin; cl02663 336982007067 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 336982007068 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 336982007069 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 336982007070 catalytic residues [active] 336982007071 Fasciclin domain; Region: Fasciclin; cl02663 336982007072 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 336982007073 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 336982007074 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif...; Region: TlpA_like_ScsD_MtbDsbE; cd03011 336982007075 catalytic residues [active] 336982007076 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 336982007077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 336982007078 FeS/SAM binding site; other site 336982007079 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 336982007080 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 336982007081 hinge region; other site 336982007082 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 336982007083 putative nucleotide binding site [chemical binding]; other site 336982007084 uridine monophosphate binding site [chemical binding]; other site 336982007085 homohexameric interface [polypeptide binding]; other site 336982007086 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 336982007087 DNA binding site [nucleotide binding] 336982007088 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 336982007089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 336982007090 Probable transposase; Region: OrfB_IS605; pfam01385 336982007091 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 336982007092 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 336982007093 catalytic residues [active] 336982007094 catalytic nucleophile [active] 336982007095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982007096 amidase; Provisional; Region: PRK07869 336982007097 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 336982007098 elongation factor Ts; Provisional; Region: tsf; PRK09377 336982007099 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 336982007100 Elongation factor TS; Region: EF_TS; pfam00889 336982007101 Elongation factor TS; Region: EF_TS; pfam00889 336982007102 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 336982007103 rRNA interaction site [nucleotide binding]; other site 336982007104 S8 interaction site; other site 336982007105 putative laminin-1 binding site; other site 336982007106 Peptidase family M23; Region: Peptidase_M23; pfam01551 336982007107 PPE family; Region: PPE; pfam00823 336982007108 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982007109 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 336982007110 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982007111 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 336982007112 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 336982007113 DNA binding site [nucleotide binding] 336982007114 Int/Topo IB signature motif; other site 336982007115 active site 336982007116 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 336982007117 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 336982007118 FAD binding pocket [chemical binding]; other site 336982007119 FAD binding motif [chemical binding]; other site 336982007120 phosphate binding motif [ion binding]; other site 336982007121 NAD binding pocket [chemical binding]; other site 336982007122 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 336982007123 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 336982007124 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 336982007125 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 336982007126 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982007127 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 336982007128 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 336982007129 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 336982007130 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 336982007131 putative molybdopterin cofactor binding site [chemical binding]; other site 336982007132 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 336982007133 putative molybdopterin cofactor binding site; other site 336982007134 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 336982007135 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 336982007136 RNA/DNA hybrid binding site [nucleotide binding]; other site 336982007137 active site 336982007138 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 336982007139 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 336982007140 Catalytic site [active] 336982007141 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 336982007142 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 336982007143 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 336982007144 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 336982007145 RimM N-terminal domain; Region: RimM; pfam01782 336982007146 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 336982007147 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 336982007148 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982007149 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 336982007150 Beta-lactamase; Region: Beta-lactamase; cl01009 336982007151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982007152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982007153 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 336982007154 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 336982007155 active site 336982007156 putative substrate binding pocket [chemical binding]; other site 336982007157 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 336982007158 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982007159 active site 336982007160 ATP binding site [chemical binding]; other site 336982007161 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 336982007162 substrate binding site [chemical binding]; other site 336982007163 activation loop (A-loop); other site 336982007164 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 336982007165 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 336982007166 active site 336982007167 signal recognition particle protein; Provisional; Region: PRK10867 336982007168 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 336982007169 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 336982007170 P loop; other site 336982007171 GTP binding site [chemical binding]; other site 336982007172 Signal peptide binding domain; Region: SRP_SPB; pfam02978 336982007173 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 336982007174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982007175 ATP binding site [chemical binding]; other site 336982007176 putative Mg++ binding site [ion binding]; other site 336982007177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982007178 ATP-binding site [chemical binding]; other site 336982007179 PII uridylyl-transferase; Provisional; Region: PRK03381 336982007180 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 336982007181 metal binding triad; other site 336982007182 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 336982007183 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 336982007184 Nitrogen regulatory protein P-II; Region: P-II; cl00412 336982007185 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 336982007186 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 336982007187 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 336982007188 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 336982007189 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 336982007190 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 336982007191 Walker A/P-loop; other site 336982007192 ATP binding site [chemical binding]; other site 336982007193 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 336982007194 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 336982007195 ABC transporter signature motif; other site 336982007196 Walker B; other site 336982007197 D-loop; other site 336982007198 H-loop/switch region; other site 336982007199 Acylphosphatase; Region: Acylphosphatase; cl00551 336982007200 OsmC-like protein; Region: OsmC; cl00767 336982007201 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 336982007202 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 336982007203 DNA binding site [nucleotide binding] 336982007204 catalytic residue [active] 336982007205 H2TH interface [polypeptide binding]; other site 336982007206 putative catalytic residues [active] 336982007207 turnover-facilitating residue; other site 336982007208 intercalation triad [nucleotide binding]; other site 336982007209 8OG recognition residue [nucleotide binding]; other site 336982007210 putative reading head residues; other site 336982007211 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 336982007212 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 336982007213 ribonuclease III; Reviewed; Region: rnc; PRK00102 336982007214 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 336982007215 dimerization interface [polypeptide binding]; other site 336982007216 active site 336982007217 metal binding site [ion binding]; metal-binding site 336982007218 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 336982007219 dsRNA binding site [nucleotide binding]; other site 336982007220 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 336982007221 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 336982007222 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 336982007223 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982007224 Thioesterase domain; Region: Thioesterase; pfam00975 336982007225 acyl-CoA synthetase; Validated; Region: PRK05850 336982007226 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982007227 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982007228 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982007229 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982007230 active site 336982007231 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982007232 PKS_DH; Region: PKS_DH; smart00826 336982007233 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 336982007234 NADP binding site [chemical binding]; other site 336982007235 active site 336982007236 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982007237 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982007238 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 336982007239 active site 336982007240 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982007241 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 336982007242 NADP binding site [chemical binding]; other site 336982007243 active site 336982007244 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982007245 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982007246 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982007247 active site 336982007248 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982007249 PKS_DH; Region: PKS_DH; smart00826 336982007250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982007251 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982007252 Enoylreductase; Region: PKS_ER; smart00829 336982007253 NAD(P) binding site [chemical binding]; other site 336982007254 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 336982007255 putative NADP binding site [chemical binding]; other site 336982007256 active site 336982007257 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982007258 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982007259 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982007260 active site 336982007261 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982007262 PKS_DH; Region: PKS_DH; smart00826 336982007263 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 336982007264 putative NADP binding site [chemical binding]; other site 336982007265 active site 336982007266 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982007267 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982007268 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982007269 active site 336982007270 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982007271 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982007272 Condensation domain; Region: Condensation; cl09290 336982007273 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 336982007274 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982007275 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 336982007276 Walker A/P-loop; other site 336982007277 ATP binding site [chemical binding]; other site 336982007278 Q-loop/lid; other site 336982007279 ABC transporter signature motif; other site 336982007280 Walker B; other site 336982007281 D-loop; other site 336982007282 H-loop/switch region; other site 336982007283 ABC-2 type transporter; Region: ABC2_membrane; cl11417 336982007284 ABC-2 type transporter; Region: ABC2_membrane; cl11417 336982007285 acyltransferase PapA5; Provisional; Region: PRK09294 336982007286 Condensation domain; Region: Condensation; cl09290 336982007287 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982007288 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982007289 active site 336982007290 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982007291 PKS_DH; Region: PKS_DH; smart00826 336982007292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982007293 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982007294 Enoylreductase; Region: PKS_ER; smart00829 336982007295 NAD(P) binding site [chemical binding]; other site 336982007296 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 336982007297 putative NADP binding site [chemical binding]; other site 336982007298 active site 336982007299 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982007300 acyl-CoA synthetase; Validated; Region: PRK05850 336982007301 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982007302 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982007303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 336982007304 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 336982007305 Integrase core domain; Region: rve; cl01316 336982007306 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 336982007307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982007308 ATP binding site [chemical binding]; other site 336982007309 Walker A motif; other site 336982007310 Walker B motif; other site 336982007311 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 336982007312 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 336982007313 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982007314 PKS_DH; Region: PKS_DH; smart00826 336982007315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982007316 Enoylreductase; Region: PKS_ER; smart00829 336982007317 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982007318 NAD(P) binding site [chemical binding]; other site 336982007319 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 336982007320 putative NADP binding site [chemical binding]; other site 336982007321 active site 336982007322 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982007323 Erythronolide synthase docking; Region: Docking; pfam08990 336982007324 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982007325 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 336982007326 active site 336982007327 acyl-CoA synthetase; Validated; Region: PRK06060 336982007328 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982007329 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982007330 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982007331 Chorismate lyase; Region: Chor_lyase; cl01230 336982007332 acyl-CoA synthetase; Validated; Region: PRK05850 336982007333 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982007334 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 336982007335 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982007336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982007337 S-adenosylmethionine binding site [chemical binding]; other site 336982007338 Uncharacterized conserved protein [Function unknown]; Region: COG3268 336982007339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982007340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982007341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982007342 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 336982007343 metal binding site [ion binding]; metal-binding site 336982007344 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 336982007345 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 336982007346 active site 336982007347 TDP-binding site; other site 336982007348 acceptor substrate-binding pocket; other site 336982007349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982007350 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 336982007351 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 336982007352 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 336982007353 active site 336982007354 TDP-binding site; other site 336982007355 acceptor substrate-binding pocket; other site 336982007356 Predicted permease; Region: DUF318; cl00487 336982007357 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 336982007358 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 336982007359 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 336982007360 putative active site [active] 336982007361 putative substrate binding site [chemical binding]; other site 336982007362 putative cosubstrate binding site; other site 336982007363 catalytic site [active] 336982007364 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 336982007365 active site 336982007366 (T/H)XGH motif; other site 336982007367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982007368 pyruvate carboxylase; Reviewed; Region: PRK12999 336982007369 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 336982007370 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 336982007371 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 336982007372 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 336982007373 active site 336982007374 catalytic residues [active] 336982007375 metal binding site [ion binding]; metal-binding site 336982007376 homodimer binding site [polypeptide binding]; other site 336982007377 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 336982007378 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 336982007379 carboxyltransferase (CT) interaction site; other site 336982007380 biotinylation site [posttranslational modification]; other site 336982007381 Vitamin K epoxide reductase family; Region: VKOR; cl01729 336982007382 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 336982007383 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982007384 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982007385 substrate binding pocket [chemical binding]; other site 336982007386 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 336982007387 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 336982007388 active site 336982007389 catalytic tetrad [active] 336982007390 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 336982007391 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 336982007392 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 336982007393 generic binding surface II; other site 336982007394 ssDNA binding site; other site 336982007395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982007396 ATP binding site [chemical binding]; other site 336982007397 putative Mg++ binding site [ion binding]; other site 336982007398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982007399 nucleotide binding region [chemical binding]; other site 336982007400 ATP-binding site [chemical binding]; other site 336982007401 DAK2 domain; Region: Dak2; cl03685 336982007402 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 336982007403 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 336982007404 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 336982007405 thiamine monophosphate kinase; Provisional; Region: PRK05731 336982007406 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 336982007407 ATP binding site [chemical binding]; other site 336982007408 dimerization interface [polypeptide binding]; other site 336982007409 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 336982007410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 336982007411 Probable transposase; Region: OrfB_IS605; pfam01385 336982007412 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 336982007413 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 336982007414 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 336982007415 catalytic residues [active] 336982007416 catalytic nucleophile [active] 336982007417 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 336982007418 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 336982007419 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 336982007420 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 336982007421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982007422 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 336982007423 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 336982007424 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982007425 polyphosphate kinase; Provisional; Region: PRK05443 336982007426 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 336982007427 putative domain interface [polypeptide binding]; other site 336982007428 putative active site [active] 336982007429 catalytic site [active] 336982007430 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 336982007431 putative domain interface [polypeptide binding]; other site 336982007432 putative active site [active] 336982007433 catalytic site [active] 336982007434 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 336982007435 active site 336982007436 Ap6A binding site [chemical binding]; other site 336982007437 nudix motif; other site 336982007438 metal binding site [ion binding]; metal-binding site 336982007439 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982007440 catalytic core [active] 336982007441 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 336982007442 IHF - DNA interface [nucleotide binding]; other site 336982007443 IHF dimer interface [polypeptide binding]; other site 336982007444 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 336982007445 substrate binding site [chemical binding]; other site 336982007446 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 336982007447 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 336982007448 substrate binding site [chemical binding]; other site 336982007449 ligand binding site [chemical binding]; other site 336982007450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982007451 Transcriptional regulator [Transcription]; Region: IclR; COG1414 336982007452 Bacterial transcriptional regulator; Region: IclR; pfam01614 336982007453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982007454 S-adenosylmethionine binding site [chemical binding]; other site 336982007455 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 336982007456 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 336982007457 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 336982007458 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982007459 active site 336982007460 HIGH motif; other site 336982007461 nucleotide binding site [chemical binding]; other site 336982007462 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 336982007463 active site 336982007464 KMSKS motif; other site 336982007465 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 336982007466 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 336982007467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982007468 Major Facilitator Superfamily; Region: MFS_1; pfam07690 336982007469 putative substrate translocation pore; other site 336982007470 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 336982007471 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 336982007472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982007473 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 336982007474 putative L-serine binding site [chemical binding]; other site 336982007475 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 336982007476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982007477 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 336982007478 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 336982007479 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982007480 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 336982007481 Walker A/P-loop; other site 336982007482 ATP binding site [chemical binding]; other site 336982007483 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 336982007484 ketol-acid reductoisomerase; Provisional; Region: PRK05479 336982007485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982007486 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 336982007487 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 336982007488 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 336982007489 putative valine binding site [chemical binding]; other site 336982007490 dimer interface [polypeptide binding]; other site 336982007491 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 336982007492 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 336982007493 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 336982007494 PYR/PP interface [polypeptide binding]; other site 336982007495 dimer interface [polypeptide binding]; other site 336982007496 TPP binding site [chemical binding]; other site 336982007497 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 336982007498 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 336982007499 TPP-binding site [chemical binding]; other site 336982007500 dimer interface [polypeptide binding]; other site 336982007501 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 336982007502 DoxX; Region: DoxX; cl00976 336982007503 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 336982007504 Flavin Reductases; Region: FlaRed; cl00801 336982007505 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 336982007506 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 336982007507 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 336982007508 GatB domain; Region: GatB_Yqey; cl11497 336982007509 6-phosphofructokinase; Provisional; Region: PRK03202 336982007510 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 336982007511 active site 336982007512 ADP/pyrophosphate binding site [chemical binding]; other site 336982007513 dimerization interface [polypeptide binding]; other site 336982007514 allosteric effector site; other site 336982007515 fructose-1,6-bisphosphate binding site; other site 336982007516 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 336982007517 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 336982007518 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 336982007519 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 336982007520 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 336982007521 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 336982007522 nucleotide binding pocket [chemical binding]; other site 336982007523 K-X-D-G motif; other site 336982007524 catalytic site [active] 336982007525 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 336982007526 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 336982007527 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 336982007528 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 336982007529 Dimer interface [polypeptide binding]; other site 336982007530 BRCT sequence motif; other site 336982007531 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step...; Region: CIMS_like; cd03310 336982007532 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982007533 PPE family; Region: PPE; pfam00823 336982007534 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982007535 PPE family; Region: PPE; pfam00823 336982007536 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982007537 MULE transposase domain; Region: MULE; pfam10551 336982007538 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 336982007539 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 336982007540 Ligand Binding Site [chemical binding]; other site 336982007541 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 336982007542 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982007543 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982007544 catalytic residue [active] 336982007545 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 336982007546 putative acyl-acceptor binding pocket; other site 336982007547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 336982007548 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 336982007549 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 336982007550 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 336982007551 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 336982007552 Ligand binding site [chemical binding]; other site 336982007553 tocopherol O-methyltransferase; Region: PLN02244 336982007554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982007555 S-adenosylmethionine binding site [chemical binding]; other site 336982007556 Uncharacterized conserved protein [Function unknown]; Region: COG1543 336982007557 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 336982007558 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 336982007559 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 336982007560 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 336982007561 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 336982007562 trimer interface [polypeptide binding]; other site 336982007563 active site 336982007564 substrate binding site [chemical binding]; other site 336982007565 CoA binding site [chemical binding]; other site 336982007566 FOG: WD40-like repeat [Function unknown]; Region: COG1520 336982007567 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 336982007568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982007569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982007570 S-adenosylmethionine binding site [chemical binding]; other site 336982007571 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982007572 substrate binding site [chemical binding]; other site 336982007573 oxyanion hole (OAH) forming residues; other site 336982007574 trimer interface [polypeptide binding]; other site 336982007575 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 336982007576 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982007577 Walker A/P-loop; other site 336982007578 ATP binding site [chemical binding]; other site 336982007579 Q-loop/lid; other site 336982007580 ABC transporter signature motif; other site 336982007581 Walker B; other site 336982007582 D-loop; other site 336982007583 H-loop/switch region; other site 336982007584 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 336982007585 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 336982007586 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 336982007587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 336982007588 motif II; other site 336982007589 hydrolase family protein; Region: PLN02887 336982007590 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 336982007591 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 336982007592 D-pathway; other site 336982007593 Putative ubiquinol binding site [chemical binding]; other site 336982007594 Low-spin heme (heme b) binding site [chemical binding]; other site 336982007595 Putative water exit pathway; other site 336982007596 Binuclear center (heme o3/CuB) [ion binding]; other site 336982007597 K-pathway; other site 336982007598 Putative proton exit pathway; other site 336982007599 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 336982007600 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 336982007601 siderophore binding site; other site 336982007602 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 336982007603 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 336982007604 putative NAD(P) binding site [chemical binding]; other site 336982007605 putative substrate binding site [chemical binding]; other site 336982007606 catalytic Zn binding site [ion binding]; other site 336982007607 structural Zn binding site [ion binding]; other site 336982007608 dimer interface [polypeptide binding]; other site 336982007609 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 336982007610 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 336982007611 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 336982007612 dimer interface [polypeptide binding]; other site 336982007613 putative radical transfer pathway; other site 336982007614 diiron center [ion binding]; other site 336982007615 tyrosyl radical; other site 336982007616 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982007617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982007618 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 336982007619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982007620 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 336982007621 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 336982007622 Class I ribonucleotide reductase; Region: RNR_I; cd01679 336982007623 active site 336982007624 dimer interface [polypeptide binding]; other site 336982007625 catalytic residues [active] 336982007626 effector binding site; other site 336982007627 R2 peptide binding site; other site 336982007628 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 336982007629 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 336982007630 catalytic residues [active] 336982007631 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 336982007632 DNA polymerase IV; Validated; Region: PRK03352 336982007633 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 336982007634 active site 336982007635 DNA binding site [nucleotide binding] 336982007636 short chain dehydrogenase; Provisional; Region: PRK05650 336982007637 classical (c) SDRs; Region: SDR_c; cd05233 336982007638 NAD(P) binding site [chemical binding]; other site 336982007639 active site 336982007640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982007641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982007642 Cytochrome P450; Region: p450; cl12078 336982007643 Transcriptional regulators [Transcription]; Region: FadR; COG2186 336982007644 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982007645 FCD domain; Region: FCD; cl11656 336982007646 Transcriptional regulators [Transcription]; Region: FadR; COG2186 336982007647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 336982007648 DNA-binding site [nucleotide binding]; DNA binding site 336982007649 FCD domain; Region: FCD; cl11656 336982007650 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982007651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982007652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982007653 active site 336982007654 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 336982007655 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 336982007656 active site 336982007657 DNA binding site [nucleotide binding] 336982007658 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 336982007659 DNA binding site [nucleotide binding] 336982007660 Carbon starvation protein CstA; Region: CstA; cl00856 336982007661 DoxX; Region: DoxX; cl00976 336982007662 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 336982007663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 336982007664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982007665 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982007666 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 336982007667 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 336982007668 active site 336982007669 substrate binding site [chemical binding]; other site 336982007670 metal binding site [ion binding]; metal-binding site 336982007671 CrcB-like protein; Region: CRCB; cl09114 336982007672 CrcB-like protein; Region: CRCB; cl09114 336982007673 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 336982007674 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 336982007675 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 336982007676 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982007677 Protein of unknown function, DUF488; Region: DUF488; cl01246 336982007678 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982007679 active site 336982007680 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 336982007681 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 336982007682 putative hydrophobic ligand binding site [chemical binding]; other site 336982007683 protein interface [polypeptide binding]; other site 336982007684 gate; other site 336982007685 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 336982007686 Sulfatase; Region: Sulfatase; cl10460 336982007687 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 336982007688 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982007689 Protein kinase domain; Region: Pkinase; pfam00069 336982007690 Catalytic domain of Protein Kinases; Region: PKc; cd00180 336982007691 active site 336982007692 ATP binding site [chemical binding]; other site 336982007693 substrate binding site [chemical binding]; other site 336982007694 activation loop (A-loop); other site 336982007695 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 336982007696 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl02058 336982007697 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 336982007698 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 336982007699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 336982007700 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982007701 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982007702 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 336982007703 short chain dehydrogenase; Provisional; Region: PRK06181 336982007704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982007705 NAD(P) binding site [chemical binding]; other site 336982007706 active site 336982007707 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 336982007708 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 336982007709 NAD binding site [chemical binding]; other site 336982007710 catalytic Zn binding site [ion binding]; other site 336982007711 substrate binding site [chemical binding]; other site 336982007712 structural Zn binding site [ion binding]; other site 336982007713 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982007714 Condensation domain; Region: Condensation; cl09290 336982007715 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982007716 Condensation domain; Region: Condensation; cl09290 336982007717 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 336982007718 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 336982007719 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982007720 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 336982007721 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 336982007722 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 336982007723 Protein of unknown function (DUF808); Region: DUF808; cl01002 336982007724 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 336982007725 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982007726 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982007727 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982007728 active site 336982007729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982007730 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 336982007731 PE family; Region: PE; pfam00934 336982007732 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 336982007733 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982007734 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 336982007735 DinB superfamily; Region: DinB_2; cl00986 336982007736 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 336982007737 SmpB-tmRNA interface; other site 336982007738 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 336982007739 FtsX-like permease family; Region: FtsX; pfam02687 336982007740 Type II (General) Secretory Pathway (IISP) Family protein; Region: 3a0501s02; TIGR00960 336982007741 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982007742 Walker A/P-loop; other site 336982007743 ATP binding site [chemical binding]; other site 336982007744 Q-loop/lid; other site 336982007745 ABC transporter signature motif; other site 336982007746 Walker B; other site 336982007747 D-loop; other site 336982007748 H-loop/switch region; other site 336982007749 Mechanosensitive ion channel; Region: MS_channel; pfam00924 336982007750 peptide chain release factor 2; Validated; Region: prfB; PRK00578 336982007751 RF-1 domain; Region: RF-1; cl02875 336982007752 RF-1 domain; Region: RF-1; cl02875 336982007753 ferredoxin-NADP+ reductase; Region: PLN02852 336982007754 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982007755 FAD binding domain; Region: FAD_binding_4; pfam01565 336982007756 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 336982007757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 336982007758 FeS/SAM binding site; other site 336982007759 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 336982007760 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 336982007761 aromatic arch; other site 336982007762 DCoH dimer interaction site [polypeptide binding]; other site 336982007763 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 336982007764 DCoH tetramer interaction site [polypeptide binding]; other site 336982007765 substrate binding site [chemical binding]; other site 336982007766 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 336982007767 trimer interface [polypeptide binding]; other site 336982007768 dimer interface [polypeptide binding]; other site 336982007769 putative active site [active] 336982007770 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 336982007771 MoaE interaction surface [polypeptide binding]; other site 336982007772 MoeB interaction surface [polypeptide binding]; other site 336982007773 thiocarboxylated glycine; other site 336982007774 hydrolase, haloacid dehalogenase-like family; Mapped to H37Rv Rv3113; interrupted by transposases 336982007775 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982007776 putative transposase OrfB; Reviewed; Region: PHA02517 336982007777 Integrase core domain; Region: rve; cl01316 336982007778 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 336982007779 nucleoside/Zn binding site; other site 336982007780 dimer interface [polypeptide binding]; other site 336982007781 catalytic motif [active] 336982007782 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982007783 MULE transposase domain; Region: MULE; pfam10551 336982007784 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 336982007785 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 336982007786 ATP binding site [chemical binding]; other site 336982007787 substrate interface [chemical binding]; other site 336982007788 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 336982007789 active site residue [active] 336982007790 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 336982007791 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 336982007792 active site residue [active] 336982007793 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 336982007794 active site residue [active] 336982007795 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 336982007796 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 336982007797 MoaE homodimer interface [polypeptide binding]; other site 336982007798 MoaD interaction [polypeptide binding]; other site 336982007799 active site residues [active] 336982007800 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 336982007801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982007802 S-adenosylmethionine binding site [chemical binding]; other site 336982007803 Cytochrome P450; Region: p450; cl12078 336982007804 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 336982007805 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209 336982007806 DNA binding site [nucleotide binding] 336982007807 PPE family; Region: PPE; pfam00823 336982007808 hypothetical protein; Provisional; Region: PRK07877 336982007809 Integrase core domain; Region: rve; cl01316 336982007810 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 336982007811 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982007812 Condensation domain; Region: Condensation; cl09290 336982007813 hypothetical protein; Provisional; Region: PRK07877 336982007814 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 336982007815 dimer interface [polypeptide binding]; other site 336982007816 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 336982007817 GAF domain; Region: GAF; cl00853 336982007818 Histidine kinase; Region: HisKA_3; pfam07730 336982007819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982007820 ATP binding site [chemical binding]; other site 336982007821 Mg2+ binding site [ion binding]; other site 336982007822 G-X-G motif; other site 336982007823 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 336982007824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 336982007825 active site 336982007826 phosphorylation site [posttranslational modification] 336982007827 intermolecular recognition site; other site 336982007828 dimerization interface [polypeptide binding]; other site 336982007829 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 336982007830 DNA binding residues [nucleotide binding] 336982007831 dimerization interface [polypeptide binding]; other site 336982007832 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 336982007833 Ligand Binding Site [chemical binding]; other site 336982007834 PPE family; Region: PPE; pfam00823 336982007835 PPE family; Region: PPE; pfam00823 336982007836 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982007837 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 336982007838 active site 336982007839 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 336982007840 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 336982007841 FeS/SAM binding site; other site 336982007842 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982007843 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982007844 active site 336982007845 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982007846 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982007847 active site 336982007848 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 336982007849 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 336982007850 NAD(P) binding site [chemical binding]; other site 336982007851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 336982007852 active site 336982007853 phosphorylation site [posttranslational modification] 336982007854 intermolecular recognition site; other site 336982007855 dimerization interface [polypeptide binding]; other site 336982007856 PPE family; Region: PPE; pfam00823 336982007857 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 336982007858 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 336982007859 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 336982007860 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 336982007861 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 336982007862 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 336982007863 putative dimer interface [polypeptide binding]; other site 336982007864 [2Fe-2S] cluster binding site [ion binding]; other site 336982007865 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 336982007866 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 336982007867 SLBB domain; Region: SLBB; pfam10531 336982007868 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 336982007869 NADH dehydrogenase subunit G; Validated; Region: PRK07860 336982007870 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982007871 catalytic loop [active] 336982007872 iron binding site [ion binding]; other site 336982007873 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 336982007874 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 336982007875 [4Fe-4S] binding site [ion binding]; other site 336982007876 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 336982007877 NADH dehydrogenase; Region: NADHdh; cl00469 336982007878 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 336982007879 4Fe-4S binding domain; Region: Fer4; cl02805 336982007880 4Fe-4S binding domain; Region: Fer4; cl02805 336982007881 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 336982007882 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 336982007883 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 336982007884 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 336982007885 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 336982007886 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 336982007887 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 336982007888 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 336982007889 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 336982007890 PPE family; Region: PPE; pfam00823 336982007891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982007892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982007893 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 336982007894 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 336982007895 [2Fe-2S] cluster binding site [ion binding]; other site 336982007896 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 336982007897 putative alpha subunit interface [polypeptide binding]; other site 336982007898 putative active site [active] 336982007899 putative substrate binding site [chemical binding]; other site 336982007900 Fe binding site [ion binding]; other site 336982007901 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 336982007902 Protein of unknown function DUF58; Region: DUF58; pfam01882 336982007903 MoxR-like ATPases [General function prediction only]; Region: COG0714 336982007904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982007905 Walker A motif; other site 336982007906 ATP binding site [chemical binding]; other site 336982007907 Walker B motif; other site 336982007908 arginine finger; other site 336982007909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982007910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982007911 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 336982007912 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 336982007913 putative active site [active] 336982007914 putative substrate binding site [chemical binding]; other site 336982007915 ATP binding site [chemical binding]; other site 336982007916 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 336982007917 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982007918 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 336982007919 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982007920 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982007921 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982007922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982007923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982007924 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 336982007925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982007926 NAD(P) binding site [chemical binding]; other site 336982007927 active site 336982007928 amidase; Provisional; Region: PRK06170 336982007929 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 336982007930 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982007931 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982007932 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982007933 Domain of unknown function (DUF385); Region: DUF385; cl04387 336982007934 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 336982007935 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982007936 putative active site [active] 336982007937 Phd_YefM; Region: PhdYeFM; cl09153 336982007938 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 336982007939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 336982007940 putative transposase OrfB; Reviewed; Region: PHA02517 336982007941 Integrase core domain; Region: rve; cl01316 336982007942 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982007943 RES domain; Region: RES; cl02411 336982007944 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 336982007945 Integrase core domain; Region: rve; cl01316 336982007946 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982007947 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 336982007948 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 336982007949 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 336982007950 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 336982007951 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 336982007952 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 336982007953 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 336982007954 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 336982007955 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 336982007956 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 336982007957 active site 336982007958 ATP binding site [chemical binding]; other site 336982007959 Transcription factor WhiB; Region: Whib; pfam02467 336982007960 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 336982007961 UvrD/REP helicase; Region: UvrD-helicase; cl14126 336982007962 HRDC domain; Region: HRDC; cl02578 336982007963 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 336982007964 catalytic residues [active] 336982007965 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 336982007966 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 336982007967 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 336982007968 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 336982007969 putative NADH binding site [chemical binding]; other site 336982007970 putative active site [active] 336982007971 nudix motif; other site 336982007972 putative metal binding site [ion binding]; other site 336982007973 Ion channel; Region: Ion_trans_2; cl11596 336982007974 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 336982007975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982007976 UvrD/REP helicase; Region: UvrD-helicase; cl14126 336982007977 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 336982007978 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 336982007979 UvrD/REP helicase; Region: UvrD-helicase; cl14126 336982007980 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 336982007981 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 336982007982 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982007983 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982007984 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 336982007985 active site 336982007986 DNA binding site [nucleotide binding] 336982007987 TIGR02569 family protein; Region: TIGR02569_actnb 336982007988 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 336982007989 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 336982007990 ATP binding site [chemical binding]; other site 336982007991 substrate interface [chemical binding]; other site 336982007992 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 336982007993 active site residue [active] 336982007994 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 336982007995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982007996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982007997 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 336982007998 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 336982007999 DEAD-like helicases superfamily; Region: DEXDc; smart00487 336982008000 ATP binding site [chemical binding]; other site 336982008001 Mg++ binding site [ion binding]; other site 336982008002 motif III; other site 336982008003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982008004 nucleotide binding region [chemical binding]; other site 336982008005 ATP-binding site [chemical binding]; other site 336982008006 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 336982008007 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 336982008008 P-loop; other site 336982008009 Magnesium ion binding site [ion binding]; other site 336982008010 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 336982008011 Magnesium ion binding site [ion binding]; other site 336982008012 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982008013 catalytic core [active] 336982008014 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 336982008015 chorismate binding enzyme; Region: Chorismate_bind; cl10555 336982008016 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 336982008017 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 336982008018 Transcription factor WhiB; Region: Whib; pfam02467 336982008019 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 336982008020 PAS domain S-box; Region: sensory_box; TIGR00229 336982008021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 336982008022 Histidine kinase; Region: HisKA_2; cl06527 336982008023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982008024 ATP binding site [chemical binding]; other site 336982008025 Mg2+ binding site [ion binding]; other site 336982008026 G-X-G motif; other site 336982008027 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 336982008028 carboxyltransferase (CT) interaction site; other site 336982008029 biotinylation site [posttranslational modification]; other site 336982008030 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 336982008031 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 336982008032 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982008033 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 336982008034 DNA binding residues [nucleotide binding] 336982008035 short chain dehydrogenase; Provisional; Region: PRK08278 336982008036 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 336982008037 NAD(P) binding site [chemical binding]; other site 336982008038 homodimer interface [polypeptide binding]; other site 336982008039 active site 336982008040 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 336982008041 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 336982008042 putative deacylase active site [active] 336982008043 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 336982008044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 336982008045 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 336982008046 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 336982008047 putative active site [active] 336982008048 putative substrate binding site [chemical binding]; other site 336982008049 ATP binding site [chemical binding]; other site 336982008050 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 336982008051 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 336982008052 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 336982008053 hinge; other site 336982008054 active site 336982008055 Predicted GTPases [General function prediction only]; Region: COG1162 336982008056 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 336982008057 GTPase/Zn-binding domain interface [polypeptide binding]; other site 336982008058 GTP/Mg2+ binding site [chemical binding]; other site 336982008059 G4 box; other site 336982008060 G5 box; other site 336982008061 G1 box; other site 336982008062 Switch I region; other site 336982008063 G2 box; other site 336982008064 G3 box; other site 336982008065 Switch II region; other site 336982008066 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 336982008067 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 336982008068 putative di-iron ligands [ion binding]; other site 336982008069 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 336982008070 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 336982008071 FAD binding pocket [chemical binding]; other site 336982008072 FAD binding motif [chemical binding]; other site 336982008073 phosphate binding motif [ion binding]; other site 336982008074 beta-alpha-beta structure motif; other site 336982008075 NAD binding pocket [chemical binding]; other site 336982008076 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982008077 catalytic loop [active] 336982008078 iron binding site [ion binding]; other site 336982008079 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 336982008080 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982008081 Condensation domain; Region: Condensation; cl09290 336982008082 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 336982008083 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 336982008084 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 336982008085 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 336982008086 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 336982008087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982008088 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 336982008089 putative substrate translocation pore; other site 336982008090 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 336982008091 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982008092 ligand binding site [chemical binding]; other site 336982008093 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 336982008094 nucleophile elbow; other site 336982008095 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 336982008096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 336982008097 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 336982008098 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 336982008099 30S subunit binding site; other site 336982008100 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 336982008101 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 336982008102 lipoprotein LpqB; Provisional; Region: PRK13616 336982008103 Sporulation and spore germination; Region: Germane; pfam10646 336982008104 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 336982008105 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 336982008106 dimerization interface [polypeptide binding]; other site 336982008107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 336982008108 dimer interface [polypeptide binding]; other site 336982008109 phosphorylation site [posttranslational modification] 336982008110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982008111 ATP binding site [chemical binding]; other site 336982008112 Mg2+ binding site [ion binding]; other site 336982008113 G-X-G motif; other site 336982008114 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982008115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 336982008116 active site 336982008117 phosphorylation site [posttranslational modification] 336982008118 intermolecular recognition site; other site 336982008119 dimerization interface [polypeptide binding]; other site 336982008120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 336982008121 DNA binding site [nucleotide binding] 336982008122 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 336982008123 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 336982008124 TMP-binding site; other site 336982008125 ATP-binding site [chemical binding]; other site 336982008126 Adenosylhomocysteinase; Provisional; Region: PTZ00075 336982008127 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 336982008128 oligomerization interface [polypeptide binding]; other site 336982008129 active site 336982008130 NAD+ binding site [chemical binding]; other site 336982008131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982008132 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 336982008133 Rubredoxin [Energy production and conversion]; Region: COG1773 336982008134 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 336982008135 iron binding site [ion binding]; other site 336982008136 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 336982008137 Rubredoxin; Region: Rubredoxin; pfam00301 336982008138 iron binding site [ion binding]; other site 336982008139 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 336982008140 Di-iron ligands [ion binding]; other site 336982008141 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 336982008142 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 336982008143 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 336982008144 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 336982008145 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 336982008146 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 336982008147 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 336982008148 active site 336982008149 substrate binding site [chemical binding]; other site 336982008150 metal binding site [ion binding]; metal-binding site 336982008151 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 336982008152 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 336982008153 Transcription factor WhiB; Region: Whib; pfam02467 336982008154 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 336982008155 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 336982008156 phosphate binding site [ion binding]; other site 336982008157 dimer interface [polypeptide binding]; other site 336982008158 substrate binding site [chemical binding]; other site 336982008159 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 336982008160 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 336982008161 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes...; Region: NADPH_oxidoreductase_1; cd02150 336982008162 putative FMN binding site [chemical binding]; other site 336982008163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982008164 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 336982008165 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 336982008166 active site 336982008167 Substrate binding site [chemical binding]; other site 336982008168 Mg++ binding site [ion binding]; other site 336982008169 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 336982008170 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 336982008171 Probable Catalytic site [active] 336982008172 metal binding site [ion binding]; metal-binding site 336982008173 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 336982008174 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 336982008175 NADP binding site [chemical binding]; other site 336982008176 active site 336982008177 putative substrate binding site [chemical binding]; other site 336982008178 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 336982008179 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982008180 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 336982008181 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 336982008182 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982008183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982008184 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 336982008185 CoA-transferase family III; Region: CoA_transf_3; cl00778 336982008186 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 336982008187 Sulfate transporter family; Region: Sulfate_transp; cl00967 336982008188 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 336982008189 active site clefts [active] 336982008190 zinc binding site [ion binding]; other site 336982008191 dimer interface [polypeptide binding]; other site 336982008192 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982008193 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 336982008194 FAD binding site [chemical binding]; other site 336982008195 homotetramer interface [polypeptide binding]; other site 336982008196 substrate binding pocket [chemical binding]; other site 336982008197 catalytic base [active] 336982008198 AIR carboxylase; Region: AIRC; cl00310 336982008199 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 336982008200 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 336982008201 GtrA-like protein; Region: GtrA; cl00971 336982008202 Bacterial membrane flanked domain; Region: DUF304; cl01348 336982008203 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 336982008204 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 336982008205 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 336982008206 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 336982008207 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 336982008208 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 336982008209 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 336982008210 active site 336982008211 dimer interface [polypeptide binding]; other site 336982008212 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 336982008213 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 336982008214 active site residue [active] 336982008215 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 336982008216 active site residue [active] 336982008217 Fe-S metabolism associated domain; Region: SufE; cl00951 336982008218 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 336982008219 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 336982008220 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 336982008221 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 336982008222 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 336982008223 carboxyltransferase (CT) interaction site; other site 336982008224 biotinylation site [posttranslational modification]; other site 336982008225 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 336982008226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982008227 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 336982008228 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 336982008229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 336982008230 L-lysine aminotransferase; Provisional; Region: PRK08297 336982008231 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 336982008232 inhibitor-cofactor binding pocket; inhibition site 336982008233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982008234 catalytic residue [active] 336982008235 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 336982008236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982008237 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 336982008238 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 336982008239 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 336982008240 tetrameric interface [polypeptide binding]; other site 336982008241 NAD binding site [chemical binding]; other site 336982008242 catalytic residues [active] 336982008243 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 336982008244 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982008245 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982008246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982008247 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 336982008248 ATP binding site [chemical binding]; other site 336982008249 putative Mg++ binding site [ion binding]; other site 336982008250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 336982008251 nucleotide binding region [chemical binding]; other site 336982008252 ATP-binding site [chemical binding]; other site 336982008253 DEAD/H associated; Region: DEAD_assoc; pfam08494 336982008254 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 336982008255 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 336982008256 putative DNA binding site [nucleotide binding]; other site 336982008257 catalytic residue [active] 336982008258 putative H2TH interface [polypeptide binding]; other site 336982008259 putative catalytic residues [active] 336982008260 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 336982008261 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 336982008262 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982008263 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 336982008264 Sulfatase; Region: Sulfatase; cl10460 336982008265 PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558 336982008266 probable active site [active] 336982008267 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 336982008268 PhoU domain; Region: PhoU; pfam01895 336982008269 PhoU domain; Region: PhoU; pfam01895 336982008270 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 336982008271 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 336982008272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982008273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982008274 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 336982008275 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 336982008276 putative active site pocket [active] 336982008277 dimerization interface [polypeptide binding]; other site 336982008278 putative catalytic residue [active] 336982008279 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 336982008280 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 336982008281 metal binding site [ion binding]; metal-binding site 336982008282 putative dimer interface [polypeptide binding]; other site 336982008283 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 336982008284 amidohydrolase; Region: amidohydrolases; TIGR01891 336982008285 metal binding site [ion binding]; metal-binding site 336982008286 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 336982008287 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 336982008288 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 336982008289 active site 336982008290 substrate binding site [chemical binding]; other site 336982008291 metal binding site [ion binding]; metal-binding site 336982008292 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 336982008293 Phosphoesterase family; Region: Phosphoesterase; cl10627 336982008294 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982008295 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 336982008296 active site 336982008297 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 336982008298 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 336982008299 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 336982008300 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 336982008301 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 336982008302 active site 336982008303 catalytic motif [active] 336982008304 Zn binding site [ion binding]; other site 336982008305 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 336982008306 putative Iron-sulfur protein interface [polypeptide binding]; other site 336982008307 putative proximal heme binding site [chemical binding]; other site 336982008308 putative SdhD-like interface [polypeptide binding]; other site 336982008309 putative distal heme binding site [chemical binding]; other site 336982008310 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 336982008311 putative Iron-sulfur protein interface [polypeptide binding]; other site 336982008312 putative proximal heme binding site [chemical binding]; other site 336982008313 putative SdhC-like subunit interface [polypeptide binding]; other site 336982008314 putative distal heme binding site [chemical binding]; other site 336982008315 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 336982008316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982008317 domain; Region: Succ_DH_flav_C; pfam02910 336982008318 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 336982008319 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982008320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982008321 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 336982008322 MoaE interaction surface [polypeptide binding]; other site 336982008323 MoeB interaction surface [polypeptide binding]; other site 336982008324 thiocarboxylated glycine; other site 336982008325 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 336982008326 MoaE homodimer interface [polypeptide binding]; other site 336982008327 MoaD interaction [polypeptide binding]; other site 336982008328 active site residues [active] 336982008329 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 336982008330 trimer interface [polypeptide binding]; other site 336982008331 dimer interface [polypeptide binding]; other site 336982008332 putative active site [active] 336982008333 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 336982008334 aromatic arch; other site 336982008335 DCoH dimer interaction site [polypeptide binding]; other site 336982008336 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 336982008337 DCoH tetramer interaction site [polypeptide binding]; other site 336982008338 substrate binding site [chemical binding]; other site 336982008339 putative transposase OrfB; Reviewed; Region: PHA02517 336982008340 Integrase core domain; Region: rve; cl01316 336982008341 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 336982008342 Transposase; Region: DEDD_Tnp_IS110; pfam01548 336982008343 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 336982008344 Uncharacterized conserved protein [Function unknown]; Region: COG2128 336982008345 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 336982008346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982008347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 336982008348 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982008349 hypothetical protein; Provisional; Region: PRK06541 336982008350 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 336982008351 inhibitor-cofactor binding pocket; inhibition site 336982008352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982008353 catalytic residue [active] 336982008354 Beta-lactamase; Region: Beta-lactamase; cl01009 336982008355 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 336982008356 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 336982008357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982008358 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 336982008359 active site 336982008360 dimer interface [polypeptide binding]; other site 336982008361 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982008362 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 336982008363 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 336982008364 DNA binding residues [nucleotide binding] 336982008365 dimer interface [polypeptide binding]; other site 336982008366 metal binding site [ion binding]; metal-binding site 336982008367 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 336982008368 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 336982008369 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 336982008370 active site 336982008371 HIGH motif; other site 336982008372 dimer interface [polypeptide binding]; other site 336982008373 KMSKS motif; other site 336982008374 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 336982008375 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 336982008376 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 336982008377 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 336982008378 homodimer interface [polypeptide binding]; other site 336982008379 substrate-cofactor binding pocket; other site 336982008380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982008381 catalytic residue [active] 336982008382 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 336982008383 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982008384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982008385 S-adenosylmethionine binding site [chemical binding]; other site 336982008386 PPE family; Region: PPE; pfam00823 336982008387 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008388 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008389 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008390 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008391 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008392 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008393 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008394 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008395 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008396 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008397 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008398 PE family; Region: PE; pfam00934 336982008399 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 336982008400 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982008401 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008402 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982008403 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008404 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008405 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008406 PPE family; Region: PPE; pfam00823 336982008407 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008408 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008409 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 336982008410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 336982008411 Transposase; Region: DDE_Tnp_ISL3; pfam01610 336982008412 PPE family; Region: PPE; pfam00823 336982008413 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008414 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008415 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008416 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008417 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008418 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008419 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008420 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982008421 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008422 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008423 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008424 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 336982008425 Berberine and berberine like; Region: BBE; pfam08031 336982008426 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982008427 Protein of unknown function (DUF732); Region: DUF732; pfam05305 336982008428 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 336982008429 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 336982008430 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 336982008431 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 336982008432 homodimer interface [polypeptide binding]; other site 336982008433 NADP binding site [chemical binding]; other site 336982008434 substrate binding site [chemical binding]; other site 336982008435 Phd_YefM; Region: PhdYeFM; cl09153 336982008436 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 336982008437 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 336982008438 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 336982008439 active site 336982008440 FMN binding site [chemical binding]; other site 336982008441 substrate binding site [chemical binding]; other site 336982008442 putative catalytic residue [active] 336982008443 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 336982008444 phosphate binding site [ion binding]; other site 336982008445 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 336982008446 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 336982008447 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 336982008448 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 336982008449 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 336982008450 G1 box; other site 336982008451 GTP/Mg2+ binding site [chemical binding]; other site 336982008452 G2 box; other site 336982008453 Switch I region; other site 336982008454 G3 box; other site 336982008455 Switch II region; other site 336982008456 G4 box; other site 336982008457 G5 box; other site 336982008458 Protein of unknown function (DUF742); Region: DUF742; pfam05331 336982008459 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 336982008460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 336982008461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982008462 ATP binding site [chemical binding]; other site 336982008463 Mg2+ binding site [ion binding]; other site 336982008464 G-X-G motif; other site 336982008465 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 336982008466 PE family; Region: PE; pfam00934 336982008467 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 336982008468 FMN binding site [chemical binding]; other site 336982008469 dimer interface [polypeptide binding]; other site 336982008470 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 336982008471 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 336982008472 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 336982008473 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 336982008474 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 336982008475 generic binding surface II; other site 336982008476 generic binding surface I; other site 336982008477 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982008478 Condensation domain; Region: Condensation; cl09290 336982008479 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 336982008480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982008481 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 336982008482 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982008483 substrate binding site [chemical binding]; other site 336982008484 oxyanion hole (OAH) forming residues; other site 336982008485 trimer interface [polypeptide binding]; other site 336982008486 enoyl-CoA hydratase; Provisional; Region: PRK06144 336982008487 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 336982008488 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 336982008489 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 336982008490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 336982008491 motif II; other site 336982008492 ent-copalyl diphosphate synthase; Region: PLN02592 336982008493 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 336982008494 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 336982008495 TPP-binding site [chemical binding]; other site 336982008496 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 336982008497 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 336982008498 PYR/PP interface [polypeptide binding]; other site 336982008499 dimer interface [polypeptide binding]; other site 336982008500 TPP binding site [chemical binding]; other site 336982008501 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 336982008502 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 336982008503 LytB protein; Region: LYTB; cl00507 336982008504 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 336982008505 substrate binding pocket [chemical binding]; other site 336982008506 chain length determination region; other site 336982008507 substrate-Mg2+ binding site; other site 336982008508 catalytic residues [active] 336982008509 aspartate-rich region 1; other site 336982008510 active site lid residues [active] 336982008511 aspartate-rich region 2; other site 336982008512 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 336982008513 putative active site [active] 336982008514 Phd_YefM; Region: PhdYeFM; cl09153 336982008515 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 336982008516 Transposase domain (DUF772); Region: DUF772; cl12084 336982008517 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 336982008518 PE family; Region: PE; pfam00934 336982008519 enoyl-CoA hydratase; Region: PLN02864 336982008520 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 336982008521 dimer interaction site [polypeptide binding]; other site 336982008522 substrate-binding tunnel; other site 336982008523 active site 336982008524 catalytic site [active] 336982008525 substrate binding site [chemical binding]; other site 336982008526 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982008527 short chain dehydrogenase; Provisional; Region: PRK07201 336982008528 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 336982008529 putative NAD(P) binding site [chemical binding]; other site 336982008530 active site 336982008531 putative substrate binding site [chemical binding]; other site 336982008532 classical (c) SDRs; Region: SDR_c; cd05233 336982008533 NAD(P) binding site [chemical binding]; other site 336982008534 active site 336982008535 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982008536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982008537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982008538 S-adenosylmethionine binding site [chemical binding]; other site 336982008539 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_3; cd02653 336982008540 active site 336982008541 DNA Polymerase Y-family; Region: PolY_like; cd03468 336982008542 DNA binding site [nucleotide binding] 336982008543 GMP synthase; Reviewed; Region: guaA; PRK00074 336982008544 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 336982008545 AMP/PPi binding site [chemical binding]; other site 336982008546 candidate oxyanion hole; other site 336982008547 catalytic triad [active] 336982008548 potential glutamine specificity residues [chemical binding]; other site 336982008549 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 336982008550 ATP Binding subdomain [chemical binding]; other site 336982008551 Ligand Binding sites [chemical binding]; other site 336982008552 Dimerization subdomain; other site 336982008553 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 336982008554 active site lid residues [active] 336982008555 substrate binding pocket [chemical binding]; other site 336982008556 catalytic residues [active] 336982008557 substrate-Mg2+ binding site; other site 336982008558 aspartate-rich region 1; other site 336982008559 aspartate-rich region 2; other site 336982008560 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 336982008561 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 336982008562 substrate binding pocket [chemical binding]; other site 336982008563 chain length determination region; other site 336982008564 substrate-Mg2+ binding site; other site 336982008565 catalytic residues [active] 336982008566 aspartate-rich region 1; other site 336982008567 active site lid residues [active] 336982008568 aspartate-rich region 2; other site 336982008569 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982008570 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 336982008571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982008572 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 336982008573 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 336982008574 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 336982008575 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 336982008576 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 336982008577 inhibitor-cofactor binding pocket; inhibition site 336982008578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982008579 catalytic residue [active] 336982008580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 336982008581 hypothetical protein; Provisional; Region: PRK07579 336982008582 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 336982008583 active site 336982008584 cosubstrate binding site; other site 336982008585 substrate binding site [chemical binding]; other site 336982008586 catalytic site [active] 336982008587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982008588 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 336982008589 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 336982008590 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 336982008591 putative active site [active] 336982008592 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 336982008593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982008594 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 336982008595 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 336982008596 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 336982008597 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 336982008598 phosphate binding site [ion binding]; other site 336982008599 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 336982008600 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 336982008601 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 336982008602 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 336982008603 active site 336982008604 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 336982008605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982008606 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 336982008607 DNA binding residues [nucleotide binding] 336982008608 Transcription factor WhiB; Region: Whib; pfam02467 336982008609 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 336982008610 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 336982008611 ring oligomerisation interface [polypeptide binding]; other site 336982008612 ATP/Mg binding site [chemical binding]; other site 336982008613 stacking interactions; other site 336982008614 hinge regions; other site 336982008615 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 336982008616 oligomerisation interface [polypeptide binding]; other site 336982008617 mobile loop; other site 336982008618 roof hairpin; other site 336982008619 UGMP family protein; Validated; Region: PRK09604 336982008620 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 336982008621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 336982008622 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 336982008623 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 336982008624 alanine racemase; Reviewed; Region: alr; PRK00053 336982008625 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 336982008626 active site 336982008627 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 336982008628 dimer interface [polypeptide binding]; other site 336982008629 substrate binding site [chemical binding]; other site 336982008630 catalytic residues [active] 336982008631 PPE family; Region: PPE; pfam00823 336982008632 PPE family; Region: PPE; pfam00823 336982008633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 336982008634 Integrase core domain; Region: rve; cl01316 336982008635 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 336982008636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982008637 Walker A motif; other site 336982008638 ATP binding site [chemical binding]; other site 336982008639 Walker B motif; other site 336982008640 arginine finger; other site 336982008641 PE family; Region: PE; pfam00934 336982008642 PPE family; Region: PPE; pfam00823 336982008643 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982008644 PPE family; Region: PPE; pfam00823 336982008645 putative transposase OrfB; Reviewed; Region: PHA02517 336982008646 Integrase core domain; Region: rve; cl01316 336982008647 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982008648 MULE transposase domain; Region: MULE; pfam10551 336982008649 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 336982008650 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 336982008651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982008652 catalytic residue [active] 336982008653 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 336982008654 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 336982008655 putative substrate binding site [chemical binding]; other site 336982008656 putative ATP binding site [chemical binding]; other site 336982008657 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 336982008658 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 336982008659 glutaminase active site [active] 336982008660 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 336982008661 dimer interface [polypeptide binding]; other site 336982008662 active site 336982008663 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 336982008664 dimer interface [polypeptide binding]; other site 336982008665 active site 336982008666 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 336982008667 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 336982008668 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 336982008669 active site 336982008670 substrate binding site [chemical binding]; other site 336982008671 metal binding site [ion binding]; metal-binding site 336982008672 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 336982008673 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 336982008674 23S rRNA interface [nucleotide binding]; other site 336982008675 L3 interface [polypeptide binding]; other site 336982008676 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982008677 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982008678 C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 336982008679 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 336982008680 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982008681 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 336982008682 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982008683 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982008684 secretion protein snm4; Region: sec_mycoba_snm4; TIGR02958 336982008685 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 336982008686 active site 336982008687 catalytic residues [active] 336982008688 Protein of unknown function (DUF690); Region: DUF690; cl04939 336982008689 Cutinase; Region: Cutinase; pfam01083 336982008690 Cutinase; Region: Cutinase; pfam01083 336982008691 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 336982008692 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 336982008693 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 336982008694 dimerization interface 3.5A [polypeptide binding]; other site 336982008695 active site 336982008696 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 336982008697 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 336982008698 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 336982008699 alphaNTD - beta interaction site [polypeptide binding]; other site 336982008700 alphaNTD homodimer interface [polypeptide binding]; other site 336982008701 alphaNTD - beta' interaction site [polypeptide binding]; other site 336982008702 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 336982008703 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 336982008704 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 336982008705 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 336982008706 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 336982008707 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 336982008708 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 336982008709 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 336982008710 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 336982008711 rRNA binding site [nucleotide binding]; other site 336982008712 predicted 30S ribosome binding site; other site 336982008713 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982008714 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 336982008715 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 336982008716 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 336982008717 NAD binding site [chemical binding]; other site 336982008718 substrate binding site [chemical binding]; other site 336982008719 homodimer interface [polypeptide binding]; other site 336982008720 active site 336982008721 Cupin domain; Region: Cupin_2; cl09118 336982008722 Domain of unknown function DUF222; Region: DUF222; pfam02720 336982008723 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 336982008724 active site 336982008725 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 336982008726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982008727 NAD(P) binding site [chemical binding]; other site 336982008728 active site 336982008729 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 336982008730 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 336982008731 active site 336982008732 catalytic residues [active] 336982008733 metal binding site [ion binding]; metal-binding site 336982008734 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 336982008735 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 336982008736 PYR/PP interface [polypeptide binding]; other site 336982008737 dimer interface [polypeptide binding]; other site 336982008738 TPP binding site [chemical binding]; other site 336982008739 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 336982008740 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 336982008741 TPP-binding site [chemical binding]; other site 336982008742 Cupin domain; Region: Cupin_2; cl09118 336982008743 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982008744 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982008745 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982008746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982008747 metabolite-proton symporter; Region: 2A0106; TIGR00883 336982008748 putative substrate translocation pore; other site 336982008749 PE family; Region: PE; pfam00934 336982008750 PPE family; Region: PPE; pfam00823 336982008751 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982008752 patatin-related protein; Region: TIGR03607 336982008753 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982008754 Condensation domain; Region: Condensation; cl09290 336982008755 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 336982008756 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 336982008757 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 336982008758 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 336982008759 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 336982008760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982008761 NAD(P) binding site [chemical binding]; other site 336982008762 active site 336982008763 DoxX; Region: DoxX; cl00976 336982008764 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 336982008765 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982008766 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982008767 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 336982008768 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 336982008769 active site 336982008770 homotetramer interface [polypeptide binding]; other site 336982008771 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982008772 mce related protein; Region: MCE; cl03606 336982008773 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982008774 mce related protein; Region: MCE; cl03606 336982008775 mce related protein; Region: MCE; cl03606 336982008776 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 336982008777 Mer2; Region: Mer2; pfam09074 336982008778 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982008779 mce related protein; Region: MCE; cl03606 336982008780 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 336982008781 mce related protein; Region: MCE; cl03606 336982008782 mce related protein; Region: MCE; cl03606 336982008783 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 336982008784 Domain of unknown function DUF140; Region: DUF140; cl00510 336982008785 Domain of unknown function DUF140; Region: DUF140; cl00510 336982008786 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 336982008787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982008788 NAD(P) binding site [chemical binding]; other site 336982008789 active site 336982008790 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 336982008791 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 336982008792 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982008793 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 336982008794 FAD binding site [chemical binding]; other site 336982008795 substrate binding site [chemical binding]; other site 336982008796 catalytic base [active] 336982008797 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982008798 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008799 active site 336982008800 acyl-CoA synthetase; Validated; Region: PRK07867 336982008801 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982008802 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982008803 PE family; Region: PE; pfam00934 336982008804 PE family; Region: PE; pfam00934 336982008805 hypothetical protein; Validated; Region: PRK07586 336982008806 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 336982008807 PYR/PP interface [polypeptide binding]; other site 336982008808 dimer interface [polypeptide binding]; other site 336982008809 TPP binding site [chemical binding]; other site 336982008810 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002 336982008811 TPP-binding site [chemical binding]; other site 336982008812 dimer interface [polypeptide binding]; other site 336982008813 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 336982008814 PE family; Region: PE; pfam00934 336982008815 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982008816 PE family; Region: PE; pfam00934 336982008817 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982008818 acyl-CoA synthetase; Validated; Region: PRK07798 336982008819 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982008820 enoyl-CoA hydratase; Provisional; Region: PRK07799 336982008821 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982008822 substrate binding site [chemical binding]; other site 336982008823 oxyanion hole (OAH) forming residues; other site 336982008824 trimer interface [polypeptide binding]; other site 336982008825 Cytochrome P450; Region: p450; cl12078 336982008826 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 336982008827 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 336982008828 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 336982008829 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 336982008830 DUF35 OB-fold domain; Region: DUF35; pfam01796 336982008831 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 336982008832 DUF35 OB-fold domain; Region: DUF35; pfam01796 336982008833 lipid-transfer protein; Provisional; Region: PRK07937 336982008834 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 336982008835 active site 336982008836 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 336982008837 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 336982008838 active site 336982008839 Uncharacterized conserved protein [Function unknown]; Region: COG3391 336982008840 NHL repeat; Region: NHL; pfam01436 336982008841 NHL repeat; Region: NHL; pfam01436 336982008842 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 336982008843 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 336982008844 trimer interface [polypeptide binding]; other site 336982008845 putative metal binding site [ion binding]; other site 336982008846 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 336982008847 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway...; Region: Rieske_RO_Alpha_KSH; cd03531 336982008848 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 336982008849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982008850 NAD(P) binding site [chemical binding]; other site 336982008851 active site 336982008852 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 336982008853 PPE family; Region: PPE; pfam00823 336982008854 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 336982008855 PPE family; Region: PPE; pfam00823 336982008856 Sec24-related protein; Provisional; Region: PTZ00395 336982008857 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 336982008858 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 336982008859 active site 336982008860 catalytic residues [active] 336982008861 metal binding site [ion binding]; metal-binding site 336982008862 DmpG-like communication domain; Region: DmpG_comm; pfam07836 336982008863 acetaldehyde dehydrogenase; Validated; Region: PRK08300 336982008864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982008865 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 336982008866 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 336982008867 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 336982008868 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982008869 enoyl-CoA hydratase; Region: PLN02864 336982008870 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 336982008871 dimer interaction site [polypeptide binding]; other site 336982008872 substrate-binding tunnel; other site 336982008873 active site 336982008874 catalytic site [active] 336982008875 substrate binding site [chemical binding]; other site 336982008876 PPE family; Region: PPE; pfam00823 336982008877 PE-PPE domain; Region: PE-PPE; pfam08237 336982008878 lipid-transfer protein; Provisional; Region: PRK07855 336982008879 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 336982008880 active site 336982008881 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 336982008882 putative active site [active] 336982008883 putative catalytic site [active] 336982008884 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 336982008885 active site 336982008886 catalytic site [active] 336982008887 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 336982008888 DUF35 OB-fold domain; Region: DUF35; pfam01796 336982008889 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982008890 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008891 active site 336982008892 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982008893 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 336982008894 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008895 active site 336982008896 Cytochrome P450; Region: p450; cl12078 336982008897 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 336982008898 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 336982008899 dimer interface [polypeptide binding]; other site 336982008900 active site 336982008901 Domain of unknown function (DUF385); Region: DUF385; cl04387 336982008902 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 336982008903 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 336982008904 homodimer interface [polypeptide binding]; other site 336982008905 NAD binding site [chemical binding]; other site 336982008906 active site 336982008907 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 336982008908 classical (c) SDRs; Region: SDR_c; cd05233 336982008909 NAD(P) binding site [chemical binding]; other site 336982008910 active site 336982008911 enoyl-CoA hydratase; Provisional; Region: PRK07938 336982008912 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982008913 substrate binding site [chemical binding]; other site 336982008914 oxyanion hole (OAH) forming residues; other site 336982008915 trimer interface [polypeptide binding]; other site 336982008916 Coenzyme A transferase; Region: CoA_trans; cl00773 336982008917 Coenzyme A transferase; Region: CoA_trans; cl00773 336982008918 Nitronate monooxygenase; Region: NMO; pfam03060 336982008919 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 336982008920 FMN binding site [chemical binding]; other site 336982008921 substrate binding site [chemical binding]; other site 336982008922 putative catalytic residue [active] 336982008923 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 336982008924 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 336982008925 putative di-iron ligands [ion binding]; other site 336982008926 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 336982008927 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 336982008928 FAD binding pocket [chemical binding]; other site 336982008929 FAD binding motif [chemical binding]; other site 336982008930 phosphate binding motif [ion binding]; other site 336982008931 beta-alpha-beta structure motif; other site 336982008932 NAD(p) ribose binding residues [chemical binding]; other site 336982008933 NAD binding pocket [chemical binding]; other site 336982008934 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 336982008935 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982008936 catalytic loop [active] 336982008937 iron binding site [ion binding]; other site 336982008938 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 336982008939 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 336982008940 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 336982008941 dimer interface [polypeptide binding]; other site 336982008942 active site 336982008943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982008944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982008945 PPE family; Region: PPE; pfam00823 336982008946 Sec24-related protein; Provisional; Region: PTZ00395 336982008947 short chain dehydrogenase; Provisional; Region: PRK07831 336982008948 classical (c) SDRs; Region: SDR_c; cd05233 336982008949 NAD(P) binding site [chemical binding]; other site 336982008950 active site 336982008951 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 336982008952 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008953 active site 336982008954 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 336982008955 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982008956 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982008957 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008958 active site 336982008959 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 336982008960 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008961 active site 336982008962 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 336982008963 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008964 active site 336982008965 aspartate aminotransferase; Provisional; Region: PRK08361 336982008966 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982008967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982008968 homodimer interface [polypeptide binding]; other site 336982008969 catalytic residue [active] 336982008970 N-acetyltransferase; Region: Acetyltransf_2; cl00949 336982008971 Flavin Reductases; Region: FlaRed; cl00801 336982008972 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 336982008973 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 336982008974 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 336982008975 active site 336982008976 Fe binding site [ion binding]; other site 336982008977 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 336982008978 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982008979 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 336982008980 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 336982008981 Flavin binding site [chemical binding]; other site 336982008982 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 336982008983 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 336982008984 FAD binding pocket [chemical binding]; other site 336982008985 FAD binding motif [chemical binding]; other site 336982008986 phosphate binding motif [ion binding]; other site 336982008987 beta-alpha-beta structure motif; other site 336982008988 NAD(p) ribose binding residues [chemical binding]; other site 336982008989 NAD binding pocket [chemical binding]; other site 336982008990 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 336982008991 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 336982008992 catalytic loop [active] 336982008993 iron binding site [ion binding]; other site 336982008994 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008995 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 336982008996 active site 336982008997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982008998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982008999 Transcriptional regulators [Transcription]; Region: PurR; COG1609 336982009000 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 336982009001 DNA binding site [nucleotide binding] 336982009002 domain linker motif; other site 336982009003 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 336982009004 putative dimerization interface [polypeptide binding]; other site 336982009005 putative ligand binding site [chemical binding]; other site 336982009006 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982009007 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 336982009008 transmembrane helices; other site 336982009009 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 336982009010 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 336982009011 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 336982009012 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 336982009013 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 336982009014 active site 336982009015 HIGH motif; other site 336982009016 nucleotide binding site [chemical binding]; other site 336982009017 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 336982009018 KMSKS motif; other site 336982009019 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 336982009020 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 336982009021 homotrimer interaction site [polypeptide binding]; other site 336982009022 zinc binding site [ion binding]; other site 336982009023 CDP-binding sites; other site 336982009024 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 336982009025 substrate binding site [chemical binding]; other site 336982009026 dimer interface [polypeptide binding]; other site 336982009027 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 336982009028 DNA repair protein RadA; Provisional; Region: PRK11823 336982009029 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 336982009030 Walker A motif/ATP binding site; other site 336982009031 ATP binding site [chemical binding]; other site 336982009032 Walker B motif; other site 336982009033 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 336982009034 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 336982009035 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 336982009036 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 336982009037 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 336982009038 active site clefts [active] 336982009039 zinc binding site [ion binding]; other site 336982009040 dimer interface [polypeptide binding]; other site 336982009041 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 336982009042 endonuclease III; Region: ENDO3c; smart00478 336982009043 minor groove reading motif; other site 336982009044 helix-hairpin-helix signature motif; other site 336982009045 substrate binding pocket [chemical binding]; other site 336982009046 active site 336982009047 FES domain; Region: FES; smart00525 336982009048 PE family; Region: PE; pfam00934 336982009049 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982009050 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 336982009051 Beta-lactamase; Region: Beta-lactamase; cl01009 336982009052 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 336982009053 PE family; Region: PE; pfam00934 336982009054 Clp protease ATP binding subunit; Region: clpC; CHL00095 336982009055 Clp amino terminal domain; Region: Clp_N; pfam02861 336982009056 Clp amino terminal domain; Region: Clp_N; pfam02861 336982009057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982009058 Walker A motif; other site 336982009059 ATP binding site [chemical binding]; other site 336982009060 Walker B motif; other site 336982009061 arginine finger; other site 336982009062 UvrB/uvrC motif; Region: UVR; pfam02151 336982009063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982009064 Walker A motif; other site 336982009065 ATP binding site [chemical binding]; other site 336982009066 Walker B motif; other site 336982009067 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 336982009068 Lsr2; Region: Lsr2; pfam11774 336982009069 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 336982009070 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 336982009071 dimer interface [polypeptide binding]; other site 336982009072 putative anticodon binding site; other site 336982009073 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 336982009074 motif 1; other site 336982009075 dimer interface [polypeptide binding]; other site 336982009076 active site 336982009077 motif 2; other site 336982009078 motif 3; other site 336982009079 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 336982009080 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 336982009081 tetramerization interface [polypeptide binding]; other site 336982009082 active site 336982009083 Pantoate-beta-alanine ligase; Region: PanC; cd00560 336982009084 pantoate--beta-alanine ligase; Region: panC; TIGR00018 336982009085 active site 336982009086 ATP-binding site [chemical binding]; other site 336982009087 pantoate-binding site; other site 336982009088 HXXH motif; other site 336982009089 Uncharacterized conserved protein [Function unknown]; Region: COG5495 336982009090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982009091 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 336982009092 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 336982009093 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 336982009094 catalytic center binding site [active] 336982009095 ATP binding site [chemical binding]; other site 336982009096 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 336982009097 homooctamer interface [polypeptide binding]; other site 336982009098 active site 336982009099 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 336982009100 dihydropteroate synthase; Region: DHPS; TIGR01496 336982009101 substrate binding pocket [chemical binding]; other site 336982009102 dimer interface [polypeptide binding]; other site 336982009103 inhibitor binding site; inhibition site 336982009104 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 336982009105 homodecamer interface [polypeptide binding]; other site 336982009106 GTP cyclohydrolase I; Provisional; Region: PLN03044 336982009107 active site 336982009108 putative catalytic site residues [active] 336982009109 zinc binding site [ion binding]; other site 336982009110 GTP-CH-I/GFRP interaction surface; other site 336982009111 FtsH Extracellular; Region: FtsH_ext; pfam06480 336982009112 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 336982009113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982009114 Walker A motif; other site 336982009115 ATP binding site [chemical binding]; other site 336982009116 Walker B motif; other site 336982009117 arginine finger; other site 336982009118 Peptidase family M41; Region: Peptidase_M41; pfam01434 336982009119 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 336982009120 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982009121 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982009122 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 336982009123 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 336982009124 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982009125 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982009126 PPE family; Region: PPE; pfam00823 336982009127 PE family; Region: PE; pfam00934 336982009128 Protein of unknown function (DUF541); Region: SIMPL; cl01077 336982009129 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 336982009130 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 336982009131 Ligand Binding Site [chemical binding]; other site 336982009132 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 336982009133 Beta-lactamase; Region: Beta-lactamase; cl01009 336982009134 PBP4 family; Region: PBP4; TIGR00666 336982009135 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 336982009136 dimer interface [polypeptide binding]; other site 336982009137 substrate binding site [chemical binding]; other site 336982009138 metal binding sites [ion binding]; metal-binding site 336982009139 Integral membrane protein TerC family; Region: TerC; cl10468 336982009140 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 336982009141 Ligand binding site [chemical binding]; other site 336982009142 Putative Catalytic site [active] 336982009143 DXD motif; other site 336982009144 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 336982009145 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 336982009146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982009147 NAD(P) binding site [chemical binding]; other site 336982009148 active site 336982009149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 336982009150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 336982009151 transposase; Provisional; Region: PRK06526 336982009152 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982009153 Transposase, Mutator family; Region: Transposase_mut; pfam00872 336982009154 MULE transposase domain; Region: MULE; pfam10551 336982009155 Fic/DOC family; Region: Fic; cl00960 336982009156 DNA polymerase III subunit delta'; Validated; Region: PRK07940 336982009157 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982009158 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 336982009159 cyclase homology domain; Region: CHD; cd07302 336982009160 nucleotidyl binding site; other site 336982009161 metal binding site [ion binding]; metal-binding site 336982009162 dimer interface [polypeptide binding]; other site 336982009163 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 336982009164 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 336982009165 active site 336982009166 interdomain interaction site; other site 336982009167 putative metal-binding site [ion binding]; other site 336982009168 nucleotide binding site [chemical binding]; other site 336982009169 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 336982009170 domain I; other site 336982009171 phosphate binding site [ion binding]; other site 336982009172 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 336982009173 domain II; other site 336982009174 domain III; other site 336982009175 nucleotide binding site [chemical binding]; other site 336982009176 DNA binding groove [nucleotide binding] 336982009177 catalytic site [active] 336982009178 domain IV; other site 336982009179 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 336982009180 DNA-binding site [nucleotide binding]; DNA binding site 336982009181 RNA-binding motif; other site 336982009182 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 336982009183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 336982009184 ATP binding site [chemical binding]; other site 336982009185 putative Mg++ binding site [ion binding]; other site 336982009186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 336982009187 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 336982009188 PE family; Region: PE; pfam00934 336982009189 PE family; Region: PE; pfam00934 336982009190 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 336982009191 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 336982009192 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 336982009193 Walker A motif; other site 336982009194 hexamer interface [polypeptide binding]; other site 336982009195 ATP binding site [chemical binding]; other site 336982009196 Walker B motif; other site 336982009197 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 336982009198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982009199 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 336982009200 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 336982009201 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 336982009202 Walker A/P-loop; other site 336982009203 ATP binding site [chemical binding]; other site 336982009204 Q-loop/lid; other site 336982009205 ABC transporter signature motif; other site 336982009206 Walker B; other site 336982009207 D-loop; other site 336982009208 H-loop/switch region; other site 336982009209 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 336982009210 Walker A/P-loop; other site 336982009211 ATP binding site [chemical binding]; other site 336982009212 Q-loop/lid; other site 336982009213 ABC transporter signature motif; other site 336982009214 Walker B; other site 336982009215 D-loop; other site 336982009216 H-loop/switch region; other site 336982009217 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 336982009218 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 336982009219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982009220 ABC-ATPase subunit interface; other site 336982009221 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 336982009222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 336982009223 dimer interface [polypeptide binding]; other site 336982009224 conserved gate region; other site 336982009225 ABC-ATPase subunit interface; other site 336982009226 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 336982009227 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 336982009228 acetyl-CoA synthetase; Provisional; Region: PRK00174 336982009229 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 336982009230 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982009231 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 336982009232 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 336982009233 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 336982009234 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 336982009235 putative active site [active] 336982009236 putative CoA binding site [chemical binding]; other site 336982009237 nudix motif; other site 336982009238 metal binding site [ion binding]; metal-binding site 336982009239 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 336982009240 catalytic residues [active] 336982009241 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 336982009242 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 336982009243 minor groove reading motif; other site 336982009244 helix-hairpin-helix signature motif; other site 336982009245 substrate binding pocket [chemical binding]; other site 336982009246 active site 336982009247 FES domain; Region: FES; smart00525 336982009248 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 336982009249 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982009250 ligand binding site [chemical binding]; other site 336982009251 flexible hinge region; other site 336982009252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 336982009253 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982009254 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 336982009255 homotrimer interaction site [polypeptide binding]; other site 336982009256 putative active site [active] 336982009257 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 336982009258 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 336982009259 P loop; other site 336982009260 Nucleotide binding site [chemical binding]; other site 336982009261 DTAP/Switch II; other site 336982009262 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 336982009263 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 336982009264 DTAP/Switch II; other site 336982009265 Switch I; other site 336982009266 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 336982009267 Transcription factor WhiB; Region: Whib; pfam02467 336982009268 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 336982009269 Transglycosylase; Region: Transgly; cl07896 336982009270 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 336982009271 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 336982009272 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 336982009273 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 336982009274 putative active site [active] 336982009275 putative metal binding site [ion binding]; other site 336982009276 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 336982009277 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 336982009278 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982009279 catalytic residue [active] 336982009280 Cytochrome P450; Region: p450; cl12078 336982009281 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 336982009282 anti sigma factor interaction site; other site 336982009283 regulatory phosphorylation site [posttranslational modification]; other site 336982009284 GatB domain; Region: GatB_Yqey; cl11497 336982009285 MoxR-like ATPases [General function prediction only]; Region: COG0714 336982009286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982009287 Walker A motif; other site 336982009288 ATP binding site [chemical binding]; other site 336982009289 Walker B motif; other site 336982009290 arginine finger; other site 336982009291 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 336982009292 Protein of unknown function DUF58; Region: DUF58; pfam01882 336982009293 Integral membrane protein DUF95; Region: DUF95; cl00572 336982009294 RDD family; Region: RDD; cl00746 336982009295 glycerol kinase; Provisional; Region: glpK; PRK00047 336982009296 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 336982009297 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 336982009298 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 336982009299 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 336982009300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982009301 S-adenosylmethionine binding site [chemical binding]; other site 336982009302 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982009303 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982009304 catalytic residue [active] 336982009305 Uncharacterized conserved protein [Function unknown]; Region: COG4301 336982009306 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 336982009307 TIGR03442 family protein; Region: TIGR03442 336982009308 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 336982009309 putative active site [active] 336982009310 putative dimer interface [polypeptide binding]; other site 336982009311 TIGR03440 family protein; Region: unchr_TIGR03440 336982009312 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 336982009313 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 336982009314 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 336982009315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982009316 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 336982009317 aspartate kinase; Reviewed; Region: PRK06635 336982009318 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 336982009319 putative nucleotide binding site [chemical binding]; other site 336982009320 putative catalytic residues [active] 336982009321 putative Mg ion binding site [ion binding]; other site 336982009322 putative aspartate binding site [chemical binding]; other site 336982009323 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 336982009324 putative allosteric regulatory site; other site 336982009325 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 336982009326 putative allosteric regulatory residue; other site 336982009327 2-isopropylmalate synthase; Validated; Region: PRK03739 336982009328 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 336982009329 active site 336982009330 catalytic residues [active] 336982009331 metal binding site [ion binding]; metal-binding site 336982009332 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 336982009333 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 336982009334 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 336982009335 active site 336982009336 substrate binding site [chemical binding]; other site 336982009337 catalytic site [active] 336982009338 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 336982009339 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 336982009340 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 336982009341 catalytic triad [active] 336982009342 recombination protein RecR; Reviewed; Region: recR; PRK00076 336982009343 RecR protein; Region: RecR; pfam02132 336982009344 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 336982009345 putative active site [active] 336982009346 putative metal-binding site [ion binding]; other site 336982009347 tetramer interface [polypeptide binding]; other site 336982009348 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 336982009349 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 336982009350 active site 336982009351 metal binding site [ion binding]; metal-binding site 336982009352 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 336982009353 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982009354 FAD binding domain; Region: FAD_binding_4; pfam01565 336982009355 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 336982009356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982009357 S-adenosylmethionine binding site [chemical binding]; other site 336982009358 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 336982009359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982009360 Walker A motif; other site 336982009361 ATP binding site [chemical binding]; other site 336982009362 Walker B motif; other site 336982009363 arginine finger; other site 336982009364 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 336982009365 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982009366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982009367 catalytic residue [active] 336982009368 Cutinase; Region: Cutinase; pfam01083 336982009369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982009370 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 336982009371 NAD(P) binding site [chemical binding]; other site 336982009372 active site 336982009373 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 336982009374 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 336982009375 putative NAD(P) binding site [chemical binding]; other site 336982009376 catalytic Zn binding site [ion binding]; other site 336982009377 Uncharacterized conserved protein [Function unknown]; Region: COG3349 336982009378 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982009379 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 336982009380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 336982009381 putative substrate translocation pore; other site 336982009382 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 336982009383 ligand binding site [chemical binding]; other site 336982009384 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 336982009385 active site 336982009386 nucleophile elbow; other site 336982009387 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 336982009388 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 336982009389 FeS/SAM binding site; other site 336982009390 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 336982009391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 336982009392 S-adenosylmethionine binding site [chemical binding]; other site 336982009393 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 336982009394 nucleotide binding site [chemical binding]; other site 336982009395 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 336982009396 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 336982009397 active site 336982009398 DNA binding site [nucleotide binding] 336982009399 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 336982009400 DNA binding site [nucleotide binding] 336982009401 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 336982009402 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 336982009403 nudix motif; other site 336982009404 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982009405 Condensation domain; Region: Condensation; cl09290 336982009406 Adenosine specific kinase; Region: Adenosine_kin; cl00796 336982009407 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 336982009408 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 336982009409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 336982009410 Uncharacterized conserved protein [Function unknown]; Region: COG2966 336982009411 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 336982009412 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 336982009413 PPE family; Region: PPE; pfam00823 336982009414 PPE family; Region: PPE; pfam00823 336982009415 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 336982009416 Condensation domain; Region: Condensation; cl09290 336982009417 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982009418 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982009419 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982009420 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982009421 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 336982009422 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 336982009423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982009424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 336982009425 dimerization interface [polypeptide binding]; other site 336982009426 putative DNA binding site [nucleotide binding]; other site 336982009427 putative Zn2+ binding site [ion binding]; other site 336982009428 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 336982009429 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 336982009430 DNA binding residues [nucleotide binding] 336982009431 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 336982009432 active site 336982009433 Int/Topo IB signature motif; other site 336982009434 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 336982009435 nucleoside/Zn binding site; other site 336982009436 dimer interface [polypeptide binding]; other site 336982009437 catalytic motif [active] 336982009438 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 336982009439 prephenate dehydrogenase; Validated; Region: PRK06545 336982009440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982009441 Protein of unknown function (DUF1089); Region: DUF1089; cl01425 336982009442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 336982009443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 336982009444 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 336982009445 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 336982009446 Walker A/P-loop; other site 336982009447 ATP binding site [chemical binding]; other site 336982009448 Q-loop/lid; other site 336982009449 ABC transporter signature motif; other site 336982009450 Walker B; other site 336982009451 D-loop; other site 336982009452 H-loop/switch region; other site 336982009453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 336982009454 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 336982009455 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 336982009456 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 336982009457 putative active site [active] 336982009458 putative substrate binding site [chemical binding]; other site 336982009459 ATP binding site [chemical binding]; other site 336982009460 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 336982009461 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982009462 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 336982009463 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 336982009464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 336982009465 dimer interface [polypeptide binding]; other site 336982009466 phosphorylation site [posttranslational modification] 336982009467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 336982009468 ATP binding site [chemical binding]; other site 336982009469 Mg2+ binding site [ion binding]; other site 336982009470 G-X-G motif; other site 336982009471 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 336982009472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 336982009473 active site 336982009474 phosphorylation site [posttranslational modification] 336982009475 intermolecular recognition site; other site 336982009476 dimerization interface [polypeptide binding]; other site 336982009477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 336982009478 DNA binding site [nucleotide binding] 336982009479 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 336982009480 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982009481 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 336982009482 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 336982009483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 336982009484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 336982009485 homodimer interface [polypeptide binding]; other site 336982009486 catalytic residue [active] 336982009487 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 336982009488 TIGR03086 family protein; Region: TIGR03086 336982009489 enoyl-CoA hydratase; Provisional; Region: PRK06142 336982009490 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 336982009491 substrate binding site [chemical binding]; other site 336982009492 oxyanion hole (OAH) forming residues; other site 336982009493 trimer interface [polypeptide binding]; other site 336982009494 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 336982009495 Beta-lactamase; Region: Beta-lactamase; cl01009 336982009496 Domain of unknown function DUF222; Region: DUF222; pfam02720 336982009497 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 336982009498 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 336982009499 NAD(P) binding site [chemical binding]; other site 336982009500 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 336982009501 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 336982009502 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 336982009503 catalytic residue [active] 336982009504 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 336982009505 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 336982009506 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 336982009507 Walker A/P-loop; other site 336982009508 ATP binding site [chemical binding]; other site 336982009509 Q-loop/lid; other site 336982009510 ABC transporter signature motif; other site 336982009511 Walker B; other site 336982009512 D-loop; other site 336982009513 H-loop/switch region; other site 336982009514 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 336982009515 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982009516 active site 336982009517 ABC-2 type transporter; Region: ABC2_membrane; cl11417 336982009518 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 336982009519 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 336982009520 NAD binding site [chemical binding]; other site 336982009521 substrate binding site [chemical binding]; other site 336982009522 active site 336982009523 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 336982009524 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982009525 active site 336982009526 Peptidase family M23; Region: Peptidase_M23; pfam01551 336982009527 Leucine carboxyl methyltransferase; Region: LCM; cl01306 336982009528 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 336982009529 C-term; Region: GreA_GreB; pfam01272 336982009530 GtrA-like protein; Region: GtrA; cl00971 336982009531 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 336982009532 FAD binding domain; Region: FAD_binding_4; pfam01565 336982009533 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 336982009534 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 336982009535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982009536 NAD(P) binding site [chemical binding]; other site 336982009537 active site 336982009538 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 336982009539 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 336982009540 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 336982009541 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 336982009542 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 336982009543 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982009544 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 336982009545 FAD binding site [chemical binding]; other site 336982009546 substrate binding site [chemical binding]; other site 336982009547 catalytic residues [active] 336982009548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 336982009549 Transposase; Region: DDE_Tnp_ISL3; pfam01610 336982009550 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 336982009551 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 336982009552 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 336982009553 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982009554 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982009555 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 336982009556 active site 336982009557 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 336982009558 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982009559 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982009560 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 336982009561 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 336982009562 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 336982009563 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982009564 Cutinase; Region: Cutinase; pfam01083 336982009565 Predicted esterase [General function prediction only]; Region: COG0627 336982009566 Predicted esterase [General function prediction only]; Region: COG0627 336982009567 UbiA prenyltransferase family; Region: UbiA; cl00337 336982009568 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 336982009569 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 336982009570 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 336982009571 active site 336982009572 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 336982009573 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 336982009574 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982009575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982009576 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 336982009577 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 336982009578 amidase catalytic site [active] 336982009579 Zn binding residues [ion binding]; other site 336982009580 substrate binding site [chemical binding]; other site 336982009581 LGFP repeat; Region: LGFP; pfam08310 336982009582 PE family; Region: PE; pfam00934 336982009583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 336982009584 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 336982009585 active site 336982009586 motif I; other site 336982009587 motif II; other site 336982009588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 336982009589 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 336982009590 putative acyl-acceptor binding pocket; other site 336982009591 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 336982009592 putative acyl-acceptor binding pocket; other site 336982009593 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 336982009594 putative acyl-acceptor binding pocket; other site 336982009595 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (...; Region: APH; cd05150 336982009596 Phosphotransferase enzyme family; Region: APH; pfam01636 336982009597 active site 336982009598 ATP binding site [chemical binding]; other site 336982009599 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 336982009600 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 336982009601 iron-sulfur cluster [ion binding]; other site 336982009602 [2Fe-2S] cluster binding site [ion binding]; other site 336982009603 Condensation domain; Region: Condensation; cl09290 336982009604 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 336982009605 PE-PPE domain; Region: PE-PPE; pfam08237 336982009606 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 336982009607 Condensation domain; Region: Condensation; cl09290 336982009608 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 336982009609 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 336982009610 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 336982009611 active site 336982009612 Acyl transferase domain; Region: Acyl_transf_1; cl08282 336982009613 PKS_DH; Region: PKS_DH; smart00826 336982009614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 336982009615 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 336982009616 Enoylreductase; Region: PKS_ER; smart00829 336982009617 NAD(P) binding site [chemical binding]; other site 336982009618 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 336982009619 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 336982009620 putative NADP binding site [chemical binding]; other site 336982009621 active site 336982009622 Phosphopantetheine attachment site; Region: PP-binding; cl09936 336982009623 acyl-CoA synthetase; Validated; Region: PRK05850 336982009624 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 336982009625 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 336982009626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 336982009627 Probable transposase; Region: OrfB_IS605; pfam01385 336982009628 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 336982009629 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 336982009630 catalytic residues [active] 336982009631 catalytic nucleophile [active] 336982009632 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 336982009633 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982009634 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 336982009635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982009636 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 336982009637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982009638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982009639 Cupin domain; Region: Cupin_2; cl09118 336982009640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 336982009641 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 336982009642 seryl-tRNA synthetase; Provisional; Region: PRK05431 336982009643 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 336982009644 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 336982009645 dimer interface [polypeptide binding]; other site 336982009646 active site 336982009647 motif 1; other site 336982009648 motif 2; other site 336982009649 motif 3; other site 336982009650 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 336982009651 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 336982009652 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 336982009653 catalytic core [active] 336982009654 prephenate dehydratase; Provisional; Region: PRK11898 336982009655 Prephenate dehydratase; Region: PDT; pfam00800 336982009656 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 336982009657 putative L-Phe binding site [chemical binding]; other site 336982009658 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 336982009659 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 336982009660 Ferritin-like domain; Region: Ferritin; pfam00210 336982009661 ferroxidase diiron center [ion binding]; other site 336982009662 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 336982009663 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 336982009664 putative active site [active] 336982009665 catalytic site [active] 336982009666 putative metal binding site [ion binding]; other site 336982009667 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 336982009668 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 336982009669 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 336982009670 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 336982009671 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 336982009672 Fimbrial protein; Region: Fimbrial; cl01416 336982009673 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 336982009674 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 336982009675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 336982009676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 336982009677 hypothetical protein; Provisional; Region: PRK07945 336982009678 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 336982009679 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 336982009680 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 336982009681 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982009682 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 336982009683 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 336982009684 active site 336982009685 dimer interface [polypeptide binding]; other site 336982009686 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 336982009687 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 336982009688 active site 336982009689 FMN binding site [chemical binding]; other site 336982009690 substrate binding site [chemical binding]; other site 336982009691 3Fe-4S cluster binding site [ion binding]; other site 336982009692 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 336982009693 domain interface; other site 336982009694 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 336982009695 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 336982009696 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 336982009697 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 336982009698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982009699 Walker A motif; other site 336982009700 ATP binding site [chemical binding]; other site 336982009701 Walker B motif; other site 336982009702 arginine finger; other site 336982009703 Protein of unknown function (DUF690); Region: DUF690; cl04939 336982009704 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 336982009705 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982009706 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 336982009707 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982009708 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982009709 PPE family; Region: PPE; pfam00823 336982009710 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982009711 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 336982009712 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 336982009713 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 336982009714 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 336982009715 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 336982009716 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 336982009717 active site 336982009718 catalytic residues [active] 336982009719 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 336982009720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 336982009721 Walker A motif; other site 336982009722 ATP binding site [chemical binding]; other site 336982009723 Walker B motif; other site 336982009724 arginine finger; other site 336982009725 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 336982009726 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 336982009727 catalytic residues [active] 336982009728 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 336982009729 active site 336982009730 catalytic residues [active] 336982009731 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 336982009732 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 336982009733 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982009734 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982009735 PPE family; Region: PPE; pfam00823 336982009736 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 336982009737 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982009738 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 336982009739 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982009740 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 336982009741 Protein of unknown function (DUF690); Region: DUF690; cl04939 336982009742 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 336982009743 Proteins of 100 residues with WXG; Region: WXG100; cl02005 336982009744 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 336982009745 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 336982009746 active site 336982009747 NTP binding site [chemical binding]; other site 336982009748 metal binding triad [ion binding]; metal-binding site 336982009749 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 336982009750 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 336982009751 Zn2+ binding site [ion binding]; other site 336982009752 Mg2+ binding site [ion binding]; other site 336982009753 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 336982009754 active site 336982009755 Ap6A binding site [chemical binding]; other site 336982009756 nudix motif; other site 336982009757 metal binding site [ion binding]; metal-binding site 336982009758 MviN-like protein; Region: MVIN; pfam03023 336982009759 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 336982009760 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 336982009761 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 336982009762 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 336982009763 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 336982009764 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 336982009765 catalytic residues [active] 336982009766 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 336982009767 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 336982009768 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 336982009769 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 336982009770 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 336982009771 active site 336982009772 metal binding site [ion binding]; metal-binding site 336982009773 ParB-like partition proteins; Region: parB_part; TIGR00180 336982009774 ParB-like nuclease domain; Region: ParBc; cl02129 336982009775 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 336982009776 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 336982009777 P-loop; other site 336982009778 Magnesium ion binding site [ion binding]; other site 336982009779 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 336982009780 Magnesium ion binding site [ion binding]; other site 336982009781 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 336982009782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 336982009783 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 336982009784 G-X-X-G motif; other site 336982009785 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 336982009786 RxxxH motif; other site 336982009787 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 336982009788 Domain of unknown function DUF37; Region: DUF37; cl00506 336982009789 Ribonuclease P; Region: Ribonuclease_P; cl00457 336982009790 Ribosomal protein L34; Region: Ribosomal_L34; cl00370