-- dump date 20111121_013415 -- class Genbank::misc_feature -- table misc_feature_note -- id note 710127000001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710127000002 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 710127000003 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 710127000004 Magnesium ion binding site [ion binding]; other site 710127000005 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 710127000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 710127000007 Walker A motif; other site 710127000008 ATP binding site [chemical binding]; other site 710127000009 Walker B motif; other site 710127000010 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 710127000011 DnaA box-binding interface [nucleotide binding]; other site 710127000012 Potential MGA_0625 ABC-type multidrug/protein/lipid (MdlB-like) transport system component gene region; MGRL004 710127000013 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710127000014 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 710127000015 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 710127000016 Walker A/P-loop; other site 710127000017 ATP binding site [chemical binding]; other site 710127000018 Q-loop/lid; other site 710127000019 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 710127000020 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710127000021 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 710127000022 Walker A/P-loop; other site 710127000023 ATP binding site [chemical binding]; other site 710127000024 Q-loop/lid; other site 710127000025 ABC transporter signature motif; other site 710127000026 Walker B; other site 710127000027 D-loop; other site 710127000028 H-loop/switch region; other site 710127000029 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 710127000030 Ribonuclease P; Region: Ribonuclease_P; cl00457 710127000031 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 710127000032 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 710127000033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 710127000034 hypothetical protein; Provisional; Region: PRK05905 710127000035 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 710127000036 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 710127000037 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 710127000038 active site 710127000039 HIGH motif; other site 710127000040 KMSK motif region; other site 710127000041 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 710127000042 tRNA binding surface [nucleotide binding]; other site 710127000043 anticodon binding site; other site 710127000044 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710127000045 putative catalytic site [active] 710127000046 putative metal binding site [ion binding]; other site 710127000047 putative phosphate binding site [ion binding]; other site 710127000048 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 710127000049 amphipathic channel; other site 710127000050 Asn-Pro-Ala signature motifs; other site 710127000051 glycerol kinase; Provisional; Region: glpK; PRK00047 710127000052 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 710127000053 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 710127000054 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 710127000055 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 710127000056 Domain of unknown function DUF31; Region: DUF31; pfam01732 710127000057 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710127000058 Ferritin-like domain; Region: Ferritin; pfam00210 710127000059 dinuclear metal binding motif [ion binding]; other site 710127000060 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 710127000061 Ligand Binding Site [chemical binding]; other site 710127000062 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 710127000063 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710127000064 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 710127000065 FtsX-like permease family; Region: FtsX; pfam02687 710127000066 FtsX-like permease family; Region: FtsX; pfam02687 710127000067 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710127000068 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 710127000069 Walker A/P-loop; other site 710127000070 ATP binding site [chemical binding]; other site 710127000071 Q-loop/lid; other site 710127000072 ABC transporter signature motif; other site 710127000073 Walker B; other site 710127000074 D-loop; other site 710127000075 H-loop/switch region; other site 710127000076 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 710127000077 homotrimer interaction site [polypeptide binding]; other site 710127000078 zinc binding site [ion binding]; other site 710127000079 CDP-binding sites; other site 710127000080 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 710127000081 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 710127000082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 710127000083 Walker A motif; other site 710127000084 ATP binding site [chemical binding]; other site 710127000085 Walker B motif; other site 710127000086 arginine finger; other site 710127000087 Peptidase family M41; Region: Peptidase_M41; pfam01434 710127000088 DAK2 domain; Region: Dak2; cl03685 710127000089 Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; Region: COG5219 710127000090 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 710127000091 dimerization domain swap beta strand [polypeptide binding]; other site 710127000092 regulatory protein interface [polypeptide binding]; other site 710127000093 active site 710127000094 regulatory phosphorylation site [posttranslational modification]; other site 710127000095 transketolase; Reviewed; Region: PRK05899 710127000096 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 710127000097 TPP-binding site [chemical binding]; other site 710127000098 dimer interface [polypeptide binding]; other site 710127000099 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 710127000100 PYR/PP interface [polypeptide binding]; other site 710127000101 dimer interface [polypeptide binding]; other site 710127000102 TPP binding site [chemical binding]; other site 710127000103 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710127000104 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 710127000105 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 710127000106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710127000107 nucleotide binding region [chemical binding]; other site 710127000108 ATP-binding site [chemical binding]; other site 710127000109 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 710127000110 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 710127000111 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 710127000112 Catalytic site; other site 710127000113 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 710127000114 Walker A/P-loop; other site 710127000115 ATP binding site [chemical binding]; other site 710127000116 Q-loop/lid; other site 710127000117 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 710127000118 Q-loop/lid; other site 710127000119 ABC transporter signature motif; other site 710127000120 Walker B; other site 710127000121 D-loop; other site 710127000122 H-loop/switch region; other site 710127000123 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710127000124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 710127000125 dimer interface [polypeptide binding]; other site 710127000126 conserved gate region; other site 710127000127 putative PBP binding loops; other site 710127000128 ABC-ATPase subunit interface; other site 710127000129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 710127000130 dimer interface [polypeptide binding]; other site 710127000131 conserved gate region; other site 710127000132 putative PBP binding loops; other site 710127000133 ABC-ATPase subunit interface; other site 710127000134 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 710127000135 DHH family; Region: DHH; pfam01368 710127000136 excinuclease ABC subunit B; Provisional; Region: PRK05298 710127000137 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710127000138 ATP binding site [chemical binding]; other site 710127000139 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710127000140 nucleotide binding region [chemical binding]; other site 710127000141 ATP-binding site [chemical binding]; other site 710127000142 Ultra-violet resistance protein B; Region: UvrB; pfam12344 710127000143 UvrB/uvrC motif; Region: UVR; pfam02151 710127000144 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710127000145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 710127000146 dimer interface [polypeptide binding]; other site 710127000147 conserved gate region; other site 710127000148 putative PBP binding loops; other site 710127000149 ABC-ATPase subunit interface; other site 710127000150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 710127000151 dimer interface [polypeptide binding]; other site 710127000152 conserved gate region; other site 710127000153 ABC-ATPase subunit interface; other site 710127000154 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 710127000155 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 710127000156 Walker A/P-loop; other site 710127000157 ATP binding site [chemical binding]; other site 710127000158 Q-loop/lid; other site 710127000159 ABC transporter signature motif; other site 710127000160 Walker B; other site 710127000161 D-loop; other site 710127000162 H-loop/switch region; other site 710127000163 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 710127000164 PhoU domain; Region: PhoU; pfam01895 710127000165 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 710127000166 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 710127000167 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 710127000168 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 710127000169 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 710127000170 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 710127000171 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 710127000172 dimer interface [polypeptide binding]; other site 710127000173 putative radical transfer pathway; other site 710127000174 diiron center [ion binding]; other site 710127000175 tyrosyl radical; other site 710127000176 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 710127000177 dimerization interface [polypeptide binding]; other site 710127000178 active site 710127000179 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 710127000180 folate binding site [chemical binding]; other site 710127000181 NADP+ binding site [chemical binding]; other site 710127000182 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 710127000183 catalytic motif [active] 710127000184 Zn binding site [ion binding]; other site 710127000185 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 710127000186 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 710127000187 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 710127000188 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 710127000189 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 710127000190 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 710127000191 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 710127000192 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 710127000193 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 710127000194 putative translocon binding site; other site 710127000195 protein-rRNA interface [nucleotide binding]; other site 710127000196 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 710127000197 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 710127000198 G-X-X-G motif; other site 710127000199 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 710127000200 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 710127000201 23S rRNA interface [nucleotide binding]; other site 710127000202 5S rRNA interface [nucleotide binding]; other site 710127000203 putative antibiotic binding site [chemical binding]; other site 710127000204 L25 interface [polypeptide binding]; other site 710127000205 L27 interface [polypeptide binding]; other site 710127000206 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cl09943 710127000207 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 710127000208 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 710127000209 KOW motif; Region: KOW; cl00354 710127000210 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 710127000211 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 710127000212 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 710127000213 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 710127000214 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 710127000215 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 710127000216 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 710127000217 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 710127000218 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 710127000219 5S rRNA interface [nucleotide binding]; other site 710127000220 L5 interface [polypeptide binding]; other site 710127000221 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 710127000222 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 710127000223 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 710127000224 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 710127000225 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 710127000226 SecY translocase; Region: SecY; pfam00344 710127000227 adenylate kinases; Region: adk; TIGR01351 710127000228 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 710127000229 AMP-binding site [chemical binding]; other site 710127000230 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 710127000231 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 710127000232 active site 710127000233 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 710127000234 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710127000235 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 710127000236 NAD binding site [chemical binding]; other site 710127000237 dimer interface [polypeptide binding]; other site 710127000238 substrate binding site [chemical binding]; other site 710127000239 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 710127000240 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 710127000241 dimer interface [polypeptide binding]; other site 710127000242 putative anticodon binding site; other site 710127000243 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 710127000244 motif 1; other site 710127000245 active site 710127000246 motif 2; other site 710127000247 motif 3; other site 710127000248 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 710127000249 HSP70 interaction site [polypeptide binding]; other site 710127000250 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 710127000251 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 710127000252 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 710127000253 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 710127000254 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 710127000255 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 710127000256 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 710127000257 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 710127000258 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710127000259 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 710127000260 16S/18S rRNA binding site [nucleotide binding]; other site 710127000261 S13e-L30e interaction site [polypeptide binding]; other site 710127000262 25S rRNA binding site [nucleotide binding]; other site 710127000263 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 710127000264 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 710127000265 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 710127000266 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710127000267 catalytic residues [active] 710127000268 DNA polymerase III PolC; Validated; Region: polC; PRK00448 710127000269 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 710127000270 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 710127000271 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 710127000272 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 710127000273 elongation factor Ts; Provisional; Region: tsf; PRK09377 710127000274 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 710127000275 Elongation factor TS; Region: EF_TS; pfam00889 710127000276 Elongation factor TS; Region: EF_TS; pfam00889 710127000277 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 710127000278 putative nucleotide binding site [chemical binding]; other site 710127000279 uridine monophosphate binding site [chemical binding]; other site 710127000280 homohexameric interface [polypeptide binding]; other site 710127000281 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 710127000282 hinge region; other site 710127000283 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 710127000284 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 710127000285 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 710127000286 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 710127000287 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 710127000288 active site 710127000289 putative substrate binding region [chemical binding]; other site 710127000290 DNA polymerase III PolC; Validated; Region: polC; PRK00448 710127000291 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 710127000292 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 710127000293 active site 710127000294 substrate binding site [chemical binding]; other site 710127000295 catalytic site [active] 710127000296 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 710127000297 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 710127000298 Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488 710127000299 putative catalytic residues [active] 710127000300 putative active site [active] 710127000301 Potential subtilisin-like protease gene region; MGRL101 710127000302 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710127000303 active site 710127000304 catalytic residues [active] 710127000305 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710127000306 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 710127000307 Walker A/P-loop; other site 710127000308 ATP binding site [chemical binding]; other site 710127000309 Q-loop/lid; other site 710127000310 ABC transporter signature motif; other site 710127000311 Walker B; other site 710127000312 D-loop; other site 710127000313 H-loop/switch region; other site 710127000314 Helicase subunit of the DNA excision repair complex [DNA replication, recombination, and repair]; Region: UvrB; COG0556 710127000315 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710127000316 active site 710127000317 catalytic residues [active] 710127000318 Potential MGA_0817 unique hypothetical membrane protein gene region; MGRL113 710127000319 transcription termination factor NusA; Region: NusA; TIGR01953 710127000320 NusA N-terminal domain; Region: NusA_N; pfam08529 710127000321 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 710127000322 G-X-X-G motif; other site 710127000323 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 710127000324 translation initiation factor IF-2; Region: IF-2; TIGR00487 710127000325 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 710127000326 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 710127000327 G1 box; other site 710127000328 putative GEF interaction site [polypeptide binding]; other site 710127000329 GTP/Mg2+ binding site [chemical binding]; other site 710127000330 Switch I region; other site 710127000331 G2 box; other site 710127000332 G3 box; other site 710127000333 Switch II region; other site 710127000334 G4 box; other site 710127000335 G5 box; other site 710127000336 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 710127000337 Translation-initiation factor 2; Region: IF-2; pfam11987 710127000338 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 710127000339 Ribosome-binding factor A; Region: RBFA; cl00542 710127000340 Potential MGA_0829 conserved hypothetical liproprotein gene region; MGRL119 710127000341 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 710127000342 RNA binding site [nucleotide binding]; other site 710127000343 active site 710127000344 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 710127000345 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 710127000346 active site 710127000347 Riboflavin kinase; Region: Flavokinase; pfam01687 710127000348 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 710127000349 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 710127000350 Ligand Binding Site [chemical binding]; other site 710127000351 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 710127000352 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 710127000353 Coenzyme A transferase; Region: CoA_trans; cl00773 710127000354 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 710127000355 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 710127000356 motif 1; other site 710127000357 active site 710127000358 motif 2; other site 710127000359 motif 3; other site 710127000360 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 710127000361 DHHA1 domain; Region: DHHA1; pfam02272 710127000362 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 710127000363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 710127000364 Peptidase family U32; Region: Peptidase_U32; cl03113 710127000365 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 710127000366 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 710127000367 Peptidase family U32; Region: Peptidase_U32; cl03113 710127000368 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 710127000369 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 710127000370 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 710127000371 putative active site [active] 710127000372 substrate binding site [chemical binding]; other site 710127000373 putative cosubstrate binding site; other site 710127000374 catalytic site [active] 710127000375 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 710127000376 substrate binding site [chemical binding]; other site 710127000377 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 710127000378 Domain of unknown function (DUF386); Region: DUF386; cl01047 710127000379 Domain of unknown function DUF28; Region: DUF28; cl00361 710127000380 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 710127000381 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 710127000382 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 710127000383 active site turn [active] 710127000384 phosphorylation site [posttranslational modification] 710127000385 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 710127000386 HPr interaction site; other site 710127000387 glycerol kinase (GK) interaction site [polypeptide binding]; other site 710127000388 active site 710127000389 phosphorylation site [posttranslational modification] 710127000390 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 710127000391 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710127000392 tetrameric interface [polypeptide binding]; other site 710127000393 activator binding site; other site 710127000394 NADP binding site [chemical binding]; other site 710127000395 substrate binding site [chemical binding]; other site 710127000396 catalytic residues [active] 710127000397 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 710127000398 peptide chain release factor 1; Validated; Region: prfA; PRK00591 710127000399 RF-1 domain; Region: RF-1; cl02875 710127000400 RF-1 domain; Region: RF-1; cl02875 710127000401 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 710127000402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 710127000403 S-adenosylmethionine binding site [chemical binding]; other site 710127000404 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 710127000405 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 710127000406 Recombination protein U; Region: RecU; cl01314 710127000407 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 710127000408 IHF - DNA interface [nucleotide binding]; other site 710127000409 IHF dimer interface [polypeptide binding]; other site 710127000410 Domain of unknown function (DUF1951); Region: DUF1951; pfam09188 710127000411 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 710127000412 23S rRNA interface [nucleotide binding]; other site 710127000413 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 710127000414 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 710127000415 core dimer interface [polypeptide binding]; other site 710127000416 peripheral dimer interface [polypeptide binding]; other site 710127000417 L10 interface [polypeptide binding]; other site 710127000418 L11 interface [polypeptide binding]; other site 710127000419 putative EF-Tu interaction site [polypeptide binding]; other site 710127000420 putative EF-G interaction site [polypeptide binding]; other site 710127000421 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 710127000422 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 710127000423 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 710127000424 HSP70 interaction site [polypeptide binding]; other site 710127000425 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 710127000426 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 710127000427 putative efflux protein, MATE family; Region: matE; TIGR00797 710127000428 MatE; Region: MatE; pfam01554 710127000429 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 710127000430 tRNA binding surface [nucleotide binding]; other site 710127000431 anticodon binding site; other site 710127000432 Potential MGA_0886/85 DnaJ-like molecular chaperone gene region; MGRL163 710127000433 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 710127000434 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 710127000435 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 710127000436 HSP70 interaction site [polypeptide binding]; other site 710127000437 Potential MGA_0889/92 conserved hypothetical protein gene region; MGRL165 710127000438 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 710127000439 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 710127000440 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 710127000441 active site 710127000442 HIGH motif; other site 710127000443 KMSKS motif; other site 710127000444 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 710127000445 tRNA binding surface [nucleotide binding]; other site 710127000446 anticodon binding site; other site 710127000447 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 710127000448 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 710127000449 G1 box; other site 710127000450 GTP/Mg2+ binding site [chemical binding]; other site 710127000451 Switch I region; other site 710127000452 G2 box; other site 710127000453 Switch II region; other site 710127000454 G3 box; other site 710127000455 G4 box; other site 710127000456 G5 box; other site 710127000457 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 710127000458 G1 box; other site 710127000459 GTP/Mg2+ binding site [chemical binding]; other site 710127000460 Switch I region; other site 710127000461 G2 box; other site 710127000462 G3 box; other site 710127000463 Switch II region; other site 710127000464 G4 box; other site 710127000465 G5 box; other site 710127000466 cytidylate kinase; Provisional; Region: cmk; PRK00023 710127000467 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 710127000468 CMP-binding site; other site 710127000469 The sites determining sugar specificity; other site 710127000470 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 710127000471 conserved cys residue [active] 710127000472 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710127000473 active site 710127000474 catalytic residues [active] 710127000475 Potential MGA_0908/11 unique hypothetical membrane protein gene region; MGRL183 710127000476 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710127000477 MULE transposase domain; Region: MULE; pfam10551 710127000478 IPP transferase; Region: IPPT; cl00403 710127000479 coproporphyrinogen III oxidase; Provisional; Region: PRK05904 710127000480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 710127000481 FeS/SAM binding site; other site 710127000482 HemN C-terminal region; Region: HemN_C; pfam06969 710127000483 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 710127000484 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 710127000485 Walker A/P-loop; other site 710127000486 ATP binding site [chemical binding]; other site 710127000487 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 710127000488 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 710127000489 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 710127000490 ABC transporter signature motif; other site 710127000491 Walker B; other site 710127000492 D-loop; other site 710127000493 H-loop/switch region; other site 710127000494 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 710127000495 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 710127000496 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 710127000497 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 710127000498 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 710127000499 Protein of unknown function (DUF3217); Region: DUF3217; pfam11506 710127000500 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 710127000501 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 710127000502 active site 710127000503 dimer interface [polypeptide binding]; other site 710127000504 motif 1; other site 710127000505 motif 2; other site 710127000506 motif 3; other site 710127000507 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 710127000508 anticodon binding site; other site 710127000509 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 710127000510 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 710127000511 active site 710127000512 ATP binding site [chemical binding]; other site 710127000513 substrate binding site [chemical binding]; other site 710127000514 dimer interface [polypeptide binding]; other site 710127000515 Cytadhesin P30/P32; Region: Cytadhesin_P30; pfam07271 710127000516 Cytadhesin P30/P32; Region: Cytadhesin_P30; pfam07271 710127000517 adhesin P1; Region: termin_org_P1; TIGR03839 710127000518 adhesin P1; Region: termin_org_P1; TIGR03839 710127000519 adhesin P1; Region: termin_org_P1; TIGR03839 710127000520 adhesin P1; Region: termin_org_P1; TIGR03839 710127000521 adhesin P1; Region: termin_org_P1; TIGR03839 710127000522 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 710127000523 adhesin P1; Region: termin_org_P1; TIGR03839 710127000524 Cytadhesin P30/P32; Region: Cytadhesin_P30; pfam07271 710127000525 histidyl-tRNA synthetase; Region: hisS; TIGR00442 710127000526 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 710127000527 dimer interface [polypeptide binding]; other site 710127000528 motif 1; other site 710127000529 active site 710127000530 motif 2; other site 710127000531 motif 3; other site 710127000532 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 710127000533 anticodon binding site; other site 710127000534 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 710127000535 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 710127000536 Dimer interface [polypeptide binding]; other site 710127000537 anticodon binding site; other site 710127000538 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 710127000539 homodimer interface [polypeptide binding]; other site 710127000540 motif 1; other site 710127000541 active site 710127000542 motif 2; other site 710127000543 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710127000544 active site 710127000545 motif 3; other site 710127000546 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 710127000547 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 710127000548 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 710127000549 synthetase active site [active] 710127000550 NTP binding site [chemical binding]; other site 710127000551 metal binding site [ion binding]; metal-binding site 710127000552 CTP synthetase; Validated; Region: pyrG; PRK05380 710127000553 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 710127000554 Catalytic site [active] 710127000555 Active site [active] 710127000556 UTP binding site [chemical binding]; other site 710127000557 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 710127000558 active site 710127000559 putative oxyanion hole; other site 710127000560 catalytic triad [active] 710127000561 Protein export membrane protein; Region: SecD_SecF; cl14618 710127000562 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 710127000563 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 710127000564 domain; Region: GreA_GreB_N; pfam03449 710127000565 C-term; Region: GreA_GreB; pfam01272 710127000566 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710127000567 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 710127000568 dimerization interface [polypeptide binding]; other site 710127000569 DPS ferroxidase diiron center [ion binding]; other site 710127000570 ion pore; other site 710127000571 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000572 Potential MGA_0968/70 VlhA.4.03 variable lipoprotein family protein gene region; MGRL220 710127000573 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000574 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000575 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000576 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000577 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000578 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000579 Potential MGA_vlhA.4.07.2a/b variable lipoprotein family protein gene region; MGRL226 710127000580 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000581 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000582 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000583 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000584 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000585 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000586 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000587 GA module; Region: GA; cl08325 710127000588 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000589 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000590 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 710127000591 trimer interface [polypeptide binding]; other site 710127000592 active site 710127000593 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 710127000594 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 710127000595 active site 710127000596 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 710127000597 lipoprotein signal peptidase; Provisional; Region: PRK14787 710127000598 DNA topoisomerase I; Validated; Region: PRK05582 710127000599 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 710127000600 conserved cys residue [active] 710127000601 potential MGA_1359 gene region; likely fragment of restriction modification methylase; MGRL243 710127000602 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 710127000603 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710127000604 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 710127000605 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 710127000606 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 710127000607 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 710127000608 RPB10 interaction site [polypeptide binding]; other site 710127000609 RPB11 interaction site [polypeptide binding]; other site 710127000610 RPB3 interaction site [polypeptide binding]; other site 710127000611 RPB12 interaction site [polypeptide binding]; other site 710127000612 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 710127000613 RPB1 interaction site [polypeptide binding]; other site 710127000614 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 710127000615 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 710127000616 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 710127000617 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 710127000618 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 710127000619 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 710127000620 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 710127000621 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 710127000622 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 710127000623 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 710127000624 G-loop; other site 710127000625 DNA binding site [nucleotide binding] 710127000626 Potential MGA_1014/1345 Unique hypothetical protein gene region intact in other M. gallisepticum strains; MGRL250 710127000627 Domain of unknown function DUF20; Region: UPF0118; cl00465 710127000628 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 710127000629 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 710127000630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 710127000631 Walker A/P-loop; other site 710127000632 ATP binding site [chemical binding]; other site 710127000633 Q-loop/lid; other site 710127000634 ABC transporter signature motif; other site 710127000635 Walker B; other site 710127000636 D-loop; other site 710127000637 H-loop/switch region; other site 710127000638 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 710127000639 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 710127000640 prolyl-tRNA synthetase; Provisional; Region: PRK08661 710127000641 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_arch_euk; cd00778 710127000642 dimer interface [polypeptide binding]; other site 710127000643 motif 1; other site 710127000644 active site 710127000645 motif 2; other site 710127000646 motif 3; other site 710127000647 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266 710127000648 anticodon binding site; other site 710127000649 Phosphopantetheine attachment site; Region: PP-binding; cl09936 710127000650 elongation factor Tu; Reviewed; Region: PRK00049 710127000651 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 710127000652 G1 box; other site 710127000653 GEF interaction site [polypeptide binding]; other site 710127000654 GTP/Mg2+ binding site [chemical binding]; other site 710127000655 Switch I region; other site 710127000656 G2 box; other site 710127000657 G3 box; other site 710127000658 Switch II region; other site 710127000659 G4 box; other site 710127000660 G5 box; other site 710127000661 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 710127000662 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 710127000663 Antibiotic Binding Site [chemical binding]; other site 710127000664 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 710127000665 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 710127000666 putative tRNA-binding site [nucleotide binding]; other site 710127000667 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 710127000668 DNA polymerase III DnaE; Validated; Region: dnaE; PRK05898 710127000669 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 710127000670 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 710127000671 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 710127000672 5'-3' exonuclease; Provisional; Region: PRK14976 710127000673 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 710127000674 active site 710127000675 metal binding site 1 [ion binding]; metal-binding site 710127000676 putative 5' ssDNA interaction site; other site 710127000677 metal binding site 3; metal-binding site 710127000678 metal binding site 2 [ion binding]; metal-binding site 710127000679 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 710127000680 putative DNA binding site [nucleotide binding]; other site 710127000681 putative metal binding site [ion binding]; other site 710127000682 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 710127000683 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 710127000684 DNA binding site [nucleotide binding] 710127000685 catalytic residue [active] 710127000686 H2TH interface [polypeptide binding]; other site 710127000687 putative catalytic residues [active] 710127000688 turnover-facilitating residue; other site 710127000689 intercalation triad [nucleotide binding]; other site 710127000690 8OG recognition residue [nucleotide binding]; other site 710127000691 putative reading head residues; other site 710127000692 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710127000693 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710127000694 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 710127000695 CoA-binding site [chemical binding]; other site 710127000696 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 710127000697 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 710127000698 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 710127000699 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710127000700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 710127000701 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 710127000702 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 710127000703 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318 710127000704 putative dimer interface [polypeptide binding]; other site 710127000705 putative anticodon binding site; other site 710127000706 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 710127000707 homodimer interface [polypeptide binding]; other site 710127000708 motif 1; other site 710127000709 motif 2; other site 710127000710 active site 710127000711 motif 3; other site 710127000712 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 710127000713 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 710127000714 substrate binding site [chemical binding]; other site 710127000715 dimer interface [polypeptide binding]; other site 710127000716 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710127000717 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 710127000718 Walker A/P-loop; other site 710127000719 ATP binding site [chemical binding]; other site 710127000720 Q-loop/lid; other site 710127000721 ABC transporter signature motif; other site 710127000722 Walker B; other site 710127000723 D-loop; other site 710127000724 H-loop/switch region; other site 710127000725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 710127000726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 710127000727 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 710127000728 catalytic residue [active] 710127000729 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710127000730 MULE transposase domain; Region: MULE; pfam10551 710127000731 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 710127000732 Potential MGA_1088/89 ABC-type transport system ATPase component gene region; MGRL294 710127000733 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710127000734 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 710127000735 Walker A/P-loop; other site 710127000736 ATP binding site [chemical binding]; other site 710127000737 Q-loop/lid; other site 710127000738 ABC transporter signature motif; other site 710127000739 Walker B; other site 710127000740 D-loop; other site 710127000741 H-loop/switch region; other site 710127000742 FtsX-like permease family; Region: FtsX; pfam02687 710127000743 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 710127000744 Catalytic site [active] 710127000745 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 710127000746 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 710127000747 asparagine synthetase A; Reviewed; Region: PRK06462 710127000748 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710127000749 motif 1; other site 710127000750 dimer interface [polypeptide binding]; other site 710127000751 active site 710127000752 motif 2; other site 710127000753 motif 3; other site 710127000754 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 710127000755 M28, and M42; Region: Zinc_peptidase_like; cl14876 710127000756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710127000757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 710127000758 S-adenosylmethionine binding site [chemical binding]; other site 710127000759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 710127000760 RmuC family; Region: RmuC; pfam02646 710127000761 Potential MGA_1108/9 predicted ISMHp1-like transposase gene region; MGA_t10; MGRL304 710127000762 Transposase [DNA replication, recombination, and repair]; Region: COG5421 710127000763 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 710127000764 Potential MGA_1113/2 gene region; MGRL307 710127000765 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 710127000766 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 710127000767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 710127000768 active site 710127000769 motif I; other site 710127000770 motif II; other site 710127000771 Potential MGA_1117/9 cytadherence-related molecule (crmB)-like protein gene region; MGRL310 710127000772 adhesin P1; Region: termin_org_P1; TIGR03839 710127000773 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 710127000774 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 710127000775 dimer interface [polypeptide binding]; other site 710127000776 substrate binding site [chemical binding]; other site 710127000777 metal binding sites [ion binding]; metal-binding site 710127000778 Protein of unknown function DUF45; Region: DUF45; cl00636 710127000779 FeS assembly ATPase SufC; Region: sufC; TIGR01978 710127000780 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 710127000781 Walker A/P-loop; other site 710127000782 ATP binding site [chemical binding]; other site 710127000783 Q-loop/lid; other site 710127000784 ABC transporter signature motif; other site 710127000785 Walker B; other site 710127000786 D-loop; other site 710127000787 H-loop/switch region; other site 710127000788 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 710127000789 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710127000790 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710127000791 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710127000792 catalytic residue [active] 710127000793 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 710127000794 trimerization site [polypeptide binding]; other site 710127000795 active site 710127000796 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 710127000797 FeS assembly protein SufB; Region: sufB; TIGR01980 710127000798 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 710127000799 HSP70 interaction site [polypeptide binding]; other site 710127000800 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 710127000801 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 710127000802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710127000803 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 710127000804 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 710127000805 HSP70 interaction site [polypeptide binding]; other site 710127000806 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710127000807 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 710127000808 Walker A/P-loop; other site 710127000809 ATP binding site [chemical binding]; other site 710127000810 Q-loop/lid; other site 710127000811 ABC transporter signature motif; other site 710127000812 Walker B; other site 710127000813 D-loop; other site 710127000814 H-loop/switch region; other site 710127000815 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 710127000816 OsmC-like protein; Region: OsmC; cl00767 710127000817 signal recognition particle protein; Provisional; Region: PRK10867 710127000818 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 710127000819 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 710127000820 P loop; other site 710127000821 GTP binding site [chemical binding]; other site 710127000822 Signal peptide binding domain; Region: SRP_SPB; pfam02978 710127000823 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 710127000824 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 710127000825 active site 710127000826 HIGH motif; other site 710127000827 dimer interface [polypeptide binding]; other site 710127000828 KMSKS motif; other site 710127000829 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 710127000830 dimer interface [polypeptide binding]; other site 710127000831 glycine-pyridoxal phosphate binding site [chemical binding]; other site 710127000832 active site 710127000833 folate binding site [chemical binding]; other site 710127000834 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 710127000835 active site 710127000836 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 710127000837 23S rRNA interface [nucleotide binding]; other site 710127000838 L3 interface [polypeptide binding]; other site 710127000839 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 710127000840 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 710127000841 GcpE protein; Region: GcpE; pfam04551 710127000842 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 710127000843 Domain of unknown function DUF31; Region: DUF31; pfam01732 710127000844 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 710127000845 ATP synthase A chain; Region: ATP-synt_A; cl00413 710127000846 ATP synthase subunit C; Region: ATP-synt_C; cl00466 710127000847 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 710127000848 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 710127000849 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 710127000850 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 710127000851 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 710127000852 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 710127000853 beta subunit interaction interface [polypeptide binding]; other site 710127000854 Walker A motif; other site 710127000855 ATP binding site [chemical binding]; other site 710127000856 Walker B motif; other site 710127000857 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710127000858 ATP synthase; Region: ATP-synt; cl00365 710127000859 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 710127000860 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 710127000861 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 710127000862 alpha subunit interaction interface [polypeptide binding]; other site 710127000863 Walker A motif; other site 710127000864 ATP binding site [chemical binding]; other site 710127000865 Walker B motif; other site 710127000866 inhibitor binding site; inhibition site 710127000867 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710127000868 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00539 710127000869 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 710127000870 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 710127000871 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 710127000872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710127000873 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 710127000874 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 710127000875 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 710127000876 substrate binding site [chemical binding]; other site 710127000877 hinge regions; other site 710127000878 ADP binding site [chemical binding]; other site 710127000879 catalytic site [active] 710127000880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 710127000881 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 710127000882 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 710127000883 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710127000884 active site 710127000885 HIGH motif; other site 710127000886 nucleotide binding site [chemical binding]; other site 710127000887 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 710127000888 active site 710127000889 KMSKS motif; other site 710127000890 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 710127000891 tRNA binding surface [nucleotide binding]; other site 710127000892 anticodon binding site; other site 710127000893 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710127000894 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 710127000895 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; cl10712 710127000896 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 710127000897 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 710127000898 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 710127000899 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 710127000900 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 710127000901 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 710127000902 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 710127000903 Amidinotransferase; Region: Amidinotransf; cl12043 710127000904 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 710127000905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 710127000906 phosphodiesterase; Provisional; Region: PRK12704 710127000907 phosphodiesterase; Provisional; Region: PRK12704 710127000908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 710127000909 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710127000910 terminal organelle assembly protein TopJ; Region: termin_org_DnaJ; TIGR03835 710127000911 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 710127000912 HSP70 interaction site [polypeptide binding]; other site 710127000913 EAGR box; Region: EAGR_box; TIGR03834 710127000914 terminal organelle assembly protein TopJ; Region: termin_org_DnaJ; TIGR03835 710127000915 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 710127000916 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 710127000917 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 710127000918 dimer interface [polypeptide binding]; other site 710127000919 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 710127000920 Potential MGA_1233/34/37 VlhA.5.01 variable lipoprotein family protein gene region; MGRL378 710127000921 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429 710127000922 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000923 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000924 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000925 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000926 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000927 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000928 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000929 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000930 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000931 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000932 Potential vlhA.5.10 variably expressed lipoprotein and hemagglutinin (VlhA) family protein gene region; MGRL387 710127000933 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000934 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000935 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000936 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000937 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 710127000938 active site 710127000939 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 710127000941 beta-phosphoglucomutase; Region: bPGM; TIGR01990 710127000942 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 710127000943 Potential MGA_1350 hypothetical protein gene region; MGRL395 710127000944 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 710127000945 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 710127000946 TPP-binding site; other site 710127000947 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 710127000948 PYR/PP interface [polypeptide binding]; other site 710127000949 dimer interface [polypeptide binding]; other site 710127000950 TPP binding site [chemical binding]; other site 710127000951 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 710127000952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 710127000953 HrcA protein C terminal domain; Region: HrcA; pfam01628 710127000954 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 710127000955 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 710127000956 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 710127000957 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 710127000958 translation initiation factor IF-3; Region: infC; TIGR00168 710127000959 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 710127000960 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 710127000961 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 710127000962 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 710127000963 23S rRNA binding site [nucleotide binding]; other site 710127000964 L21 binding site [polypeptide binding]; other site 710127000965 L13 binding site [polypeptide binding]; other site 710127000966 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 710127000967 dUTPase; Region: dUTPase_2; pfam08761 710127000968 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 710127000969 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 710127000970 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 710127000971 dimer interface [polypeptide binding]; other site 710127000972 motif 1; other site 710127000973 active site 710127000974 motif 2; other site 710127000975 motif 3; other site 710127000976 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 710127000977 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 710127000978 putative tRNA-binding site [nucleotide binding]; other site 710127000979 B3/4 domain; Region: B3_4; cl11458 710127000980 tRNA synthetase B5 domain; Region: B5; cl08394 710127000981 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 710127000982 dimer interface [polypeptide binding]; other site 710127000983 motif 1; other site 710127000984 motif 3; other site 710127000985 motif 2; other site 710127000986 4-coumarate--CoA ligase; Region: PLN02246 710127000987 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 710127000988 P-loop; other site 710127000989 active site 710127000990 phosphorylation site [posttranslational modification] 710127000991 Potential MGA_1284/5 ABC transporter ATP-binding protein gene region; MGRL408 710127000992 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 710127000993 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 710127000994 Q-loop/lid; other site 710127000995 ABC transporter signature motif; other site 710127000996 Walker B; other site 710127000997 D-loop; other site 710127000998 H-loop/switch region; other site 710127000999 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710127001000 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 710127001001 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 710127001002 Walker A/P-loop; other site 710127001003 ATP binding site [chemical binding]; other site 710127001004 Q-loop/lid; other site 710127001005 ABC transporter signature motif; other site 710127001006 Walker B; other site 710127001007 D-loop; other site 710127001008 H-loop/switch region; other site 710127001009 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 710127001010 Protein of unknown function (DUF464); Region: DUF464; cl01080 710127001011 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 710127001012 endonuclease IV; Provisional; Region: PRK01060 710127001013 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 710127001014 AP (apurinic/apyrimidinic) site pocket; other site 710127001015 DNA interaction; other site 710127001016 Metal-binding active site; metal-binding site 710127001017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 710127001018 Protein of unknown function (DUF3196); Region: DUF3196; pfam11428 710127001019 trigger factor; Region: tig; TIGR00115 710127001020 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 710127001021 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 710127001022 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 710127001023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 710127001024 Walker A motif; other site 710127001025 ATP binding site [chemical binding]; other site 710127001026 Walker B motif; other site 710127001027 arginine finger; other site 710127001028 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 710127001029 ABC-2 type transporter; Region: ABC2_membrane; cl11417 710127001030 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710127001031 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 710127001032 Walker A/P-loop; other site 710127001033 ATP binding site [chemical binding]; other site 710127001034 Q-loop/lid; other site 710127001035 ABC transporter signature motif; other site 710127001036 Walker B; other site 710127001037 D-loop; other site 710127001038 H-loop/switch region; other site 710127001039 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 710127001040 putative active site [active] 710127001041 putative catalytic site [active] 710127001042 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710127001043 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 710127001044 putative active site [active] 710127001045 metal binding site [ion binding]; metal-binding site 710127001046 homodimer binding site [polypeptide binding]; other site 710127001047 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 710127001048 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 710127001049 UvrD/REP helicase; Region: UvrD-helicase; cl14126 710127001050 RDD family; Region: RDD; cl00746 710127001051 NifU-like domain; Region: NifU; cl00484 710127001052 Domain of unknown function (DUF205); Region: DUF205; cl00410 710127001053 Uncharacterized conserved protein [Function unknown]; Region: COG0327 710127001054 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 710127001055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 710127001056 RNA polymerase sigma factor; Provisional; Region: PRK05901 710127001057 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710127001058 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710127001059 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 710127001060 DNA binding residues [nucleotide binding] 710127001061 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 710127001062 CHC2 zinc finger; Region: zf-CHC2; cl02597 710127001063 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 710127001064 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 710127001065 active site 710127001066 metal binding site [ion binding]; metal-binding site 710127001067 interdomain interaction site; other site 710127001068 glycyl-tRNA synthetase; Provisional; Region: PRK04173 710127001069 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710127001070 motif 1; other site 710127001071 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 710127001072 active site 710127001073 motif 2; other site 710127001074 motif 3; other site 710127001075 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266 710127001076 anticodon binding site; other site 710127001077 Recombination protein O N terminal; Region: RecO_N; pfam11967 710127001078 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 710127001079 GTPase Era; Reviewed; Region: era; PRK00089 710127001080 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 710127001081 G1 box; other site 710127001082 GTP/Mg2+ binding site [chemical binding]; other site 710127001083 Switch I region; other site 710127001084 G2 box; other site 710127001085 Switch II region; other site 710127001086 G3 box; other site 710127001087 G4 box; other site 710127001088 G5 box; other site 710127001089 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 710127001090 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 710127001091 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 710127001092 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39E; cd02424 710127001093 putative active site [active] 710127001094 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 710127001095 Walker A/P-loop; other site 710127001096 ATP binding site [chemical binding]; other site 710127001097 Q-loop/lid; other site 710127001098 ABC transporter signature motif; other site 710127001099 Walker B; other site 710127001100 D-loop; other site 710127001101 H-loop/switch region; other site 710127001102 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 710127001103 nucleotide binding site [chemical binding]; other site 710127001104 SulA interaction site; other site 710127001105 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 710127001106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 710127001107 cell division protein MraZ; Reviewed; Region: PRK00326 710127001108 MraZ protein; Region: MraZ; pfam02381 710127001109 MraZ protein; Region: MraZ; pfam02381 710127001110 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 710127001111 segregation and condensation protein A/unknown domain fusion protein; Provisional; Region: scpA; PRK00478 710127001112 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 710127001113 folate binding site [chemical binding]; other site 710127001114 NADP+ binding site [chemical binding]; other site 710127001115 ScpA/B protein; Region: ScpA_ScpB; cl00598 710127001116 Selenoprotein S (SelS); Region: Selenoprotein_S; pfam06936 710127001117 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710127001118 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710127001119 putative acyl-acceptor binding pocket; other site 710127001120 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 710127001121 cell division protein GpsB; Provisional; Region: PRK14127 710127001122 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 710127001123 RNA/DNA hybrid binding site [nucleotide binding]; other site 710127001124 active site 710127001125 hypothetical protein; Provisional; Region: PRK06148 710127001126 LemA family; Region: LemA; cl00742 710127001127 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 710127001128 Potential MGA_0050/1318/0049/1317 hypothetical membrane protein gene region; MGRL456 710127001129 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 710127001130 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 710127001131 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 710127001132 active site 710127001133 (T/H)XGH motif; other site 710127001134 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 710127001135 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 710127001136 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 710127001137 GTP/Mg2+ binding site [chemical binding]; other site 710127001138 G4 box; other site 710127001139 G5 box; other site 710127001140 G1 box; other site 710127001141 Switch I region; other site 710127001142 G2 box; other site 710127001143 G3 box; other site 710127001144 Switch II region; other site 710127001145 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 710127001146 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 710127001147 CAP-like domain; other site 710127001148 Active site [active] 710127001149 primary dimer interface [polypeptide binding]; other site 710127001150 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710127001151 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 710127001152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710127001153 ATP binding site [chemical binding]; other site 710127001154 Mg2+ binding site [ion binding]; other site 710127001155 G-X-G motif; other site 710127001156 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 710127001157 anchoring element; other site 710127001158 dimer interface [polypeptide binding]; other site 710127001159 ATP binding site [chemical binding]; other site 710127001160 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 710127001161 active site 710127001162 putative metal-binding site [ion binding]; other site 710127001163 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 710127001164 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 710127001165 IHF - DNA interface [nucleotide binding]; other site 710127001166 IHF dimer interface [polypeptide binding]; other site 710127001167 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001168 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001169 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001170 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001171 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001172 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001173 Potential MGA_0073 predicted transposase gene region; MGA_t12; MGRL471 710127001174 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710127001175 MULE transposase domain; Region: MULE; pfam10551 710127001176 hypothetical protein; Provisional; Region: PRK12472 710127001177 GA module; Region: GA; cl08325 710127001178 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001179 Potential MGA_0080/79 VlhA1.08 variable lipoprotein family protein gene region; MGRL474 710127001180 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001181 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710127001182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710127001183 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 710127001184 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 710127001185 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 710127001186 HIGH motif; other site 710127001187 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710127001188 active site 710127001189 KMSKS motif; other site 710127001190 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 710127001191 tRNA binding surface [nucleotide binding]; other site 710127001192 anticodon binding site; other site 710127001193 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 710127001194 substrate binding site [chemical binding]; other site 710127001195 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 710127001196 substrate binding site [chemical binding]; other site 710127001197 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 710127001198 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710127001199 active site 710127001200 catalytic tetrad [active] 710127001201 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH...; Region: Peptidase_C1B; cd00585 710127001202 trimer interface [polypeptide binding]; other site 710127001203 active site 710127001204 G bulge; other site 710127001205 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH...; Region: Peptidase_C1B; cd00585 710127001206 trimer interface [polypeptide binding]; other site 710127001207 active site 710127001208 G bulge; other site 710127001209 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 710127001210 SmpB-tmRNA interface; other site 710127001211 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710127001212 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710127001213 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 710127001214 active site 710127001215 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 710127001216 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 710127001217 Amidinotransferase; Region: Amidinotransf; cl12043 710127001218 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 710127001219 Sugar specificity; other site 710127001220 Pyrimidine base specificity; other site 710127001221 ATP-binding site [chemical binding]; other site 710127001222 GTPase CgtA; Reviewed; Region: obgE; PRK12297 710127001223 GTP1/OBG; Region: GTP1_OBG; pfam01018 710127001224 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 710127001225 G1 box; other site 710127001226 GTP/Mg2+ binding site [chemical binding]; other site 710127001227 Switch I region; other site 710127001228 G2 box; other site 710127001229 G3 box; other site 710127001230 Switch II region; other site 710127001231 G4 box; other site 710127001232 G5 box; other site 710127001233 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 710127001234 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 710127001235 interface (dimer of trimers) [polypeptide binding]; other site 710127001236 Substrate-binding/catalytic site; other site 710127001237 Zn-binding sites [ion binding]; other site 710127001238 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 710127001239 gating phenylalanine in ion channel; other site 710127001240 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001241 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 710127001242 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001243 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 710127001244 ribonuclease R; Region: RNase_R; TIGR02063 710127001245 RNB domain; Region: RNB; pfam00773 710127001246 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 710127001247 RNA binding site [nucleotide binding]; other site 710127001248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 710127001249 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 710127001250 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 710127001251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 710127001252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710127001253 DNA-binding site [nucleotide binding]; DNA binding site 710127001254 S-adenosylmethionine synthetase; Validated; Region: PRK05250 710127001255 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 710127001256 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 710127001257 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 710127001258 putative glycoprotease GCP; Region: bact_gcp; TIGR03723 710127001259 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 710127001260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710127001261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 710127001262 dimer interface [polypeptide binding]; other site 710127001263 conserved gate region; other site 710127001264 putative PBP binding loops; other site 710127001265 ABC-ATPase subunit interface; other site 710127001266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 710127001267 dimer interface [polypeptide binding]; other site 710127001268 conserved gate region; other site 710127001269 putative PBP binding loops; other site 710127001270 ABC-ATPase subunit interface; other site 710127001271 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 710127001272 Walker A/P-loop; other site 710127001273 ATP binding site [chemical binding]; other site 710127001274 Q-loop/lid; other site 710127001275 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 710127001276 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 710127001277 ABC transporter signature motif; other site 710127001278 Walker B; other site 710127001279 D-loop; other site 710127001280 H-loop/switch region; other site 710127001281 hypothetical protein; Provisional; Region: PRK12705 710127001282 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 710127001283 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 710127001284 recombinase A; Provisional; Region: recA; PRK09354 710127001285 hexamer interface [polypeptide binding]; other site 710127001286 Walker A motif; other site 710127001287 ATP binding site [chemical binding]; other site 710127001288 Walker B motif; other site 710127001289 Potential MGA_0145 predicted transposase gene region; MGA_t13; MGRL518 710127001290 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710127001291 MULE transposase domain; Region: MULE; pfam10551 710127001292 Potential MGA_0148/7 predicted transposase gene region; MGA_t14; MGRL519 710127001293 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710127001294 MULE transposase domain; Region: MULE; pfam10551 710127001295 SelR domain; Region: SelR; cl00369 710127001296 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 710127001297 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 710127001298 ring oligomerisation interface [polypeptide binding]; other site 710127001299 ATP/Mg binding site [chemical binding]; other site 710127001300 stacking interactions; other site 710127001301 hinge regions; other site 710127001302 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 710127001303 oligomerisation interface [polypeptide binding]; other site 710127001304 mobile loop; other site 710127001305 roof hairpin; other site 710127001306 pyruvate kinase; Provisional; Region: PRK05826 710127001307 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 710127001308 domain interfaces; other site 710127001309 active site 710127001310 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 710127001311 6-phosphofructokinase; Provisional; Region: PRK03202 710127001312 active site 710127001313 ADP/pyrophosphate binding site [chemical binding]; other site 710127001314 dimerization interface [polypeptide binding]; other site 710127001315 allosteric effector site; other site 710127001316 fructose-1,6-bisphosphate binding site; other site 710127001317 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 710127001318 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 710127001319 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 710127001320 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 710127001321 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 710127001322 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 710127001323 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710127001324 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710127001325 E3 interaction surface; other site 710127001326 lipoyl attachment site [posttranslational modification]; other site 710127001327 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 710127001328 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710127001329 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 710127001330 alpha subunit interface [polypeptide binding]; other site 710127001331 TPP binding site [chemical binding]; other site 710127001332 heterodimer interface [polypeptide binding]; other site 710127001333 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710127001334 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 710127001335 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710127001336 tetramer interface [polypeptide binding]; other site 710127001337 TPP-binding site [chemical binding]; other site 710127001338 heterodimer interface [polypeptide binding]; other site 710127001339 phosphorylation loop region [posttranslational modification] 710127001340 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 710127001341 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 710127001342 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710127001343 Acetokinase family; Region: Acetate_kinase; cl01029 710127001344 Cation transport protein; Region: TrkH; cl10514 710127001345 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 710127001346 Cation transport protein; Region: TrkH; cl10514 710127001347 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710127001348 Domain of unknown function DUF21; Region: DUF21; pfam01595 710127001349 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710127001350 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 710127001351 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 710127001352 Substrate-binding site [chemical binding]; other site 710127001353 Substrate specificity [chemical binding]; other site 710127001354 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 710127001355 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 710127001356 Substrate-binding site [chemical binding]; other site 710127001357 Substrate specificity [chemical binding]; other site 710127001358 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 710127001359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 710127001360 Walker A motif; other site 710127001361 ATP binding site [chemical binding]; other site 710127001362 Walker B motif; other site 710127001363 arginine finger; other site 710127001364 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 710127001365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 710127001366 Walker A motif; other site 710127001367 ATP binding site [chemical binding]; other site 710127001368 Walker B motif; other site 710127001369 arginine finger; other site 710127001370 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 710127001371 ribonuclease III; Reviewed; Region: rnc; PRK00102 710127001372 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 710127001373 dimerization interface [polypeptide binding]; other site 710127001374 active site 710127001375 metal binding site [ion binding]; metal-binding site 710127001376 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 710127001377 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 710127001378 DAK2 domain; Region: Dak2; cl03685 710127001379 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 710127001380 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 710127001381 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 710127001382 active site 710127001383 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710127001384 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 710127001385 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 710127001386 DHH family; Region: DHH; pfam01368 710127001387 DHHA1 domain; Region: DHHA1; pfam02272 710127001388 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 710127001389 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 710127001390 Ligand Binding Site [chemical binding]; other site 710127001391 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 710127001392 EAGR box; Region: EAGR_box; TIGR03834 710127001393 EAGR box; Region: EAGR_box; TIGR03834 710127001394 EAGR box; Region: EAGR_box; TIGR03834 710127001395 terminal organelle assembly protein TopJ; Region: termin_org_DnaJ; TIGR03835 710127001396 EAGR box; Region: EAGR_box; TIGR03834 710127001397 EAGR box; Region: EAGR_box; TIGR03834 710127001398 terminal organelle assembly protein TopJ; Region: termin_org_DnaJ; TIGR03835 710127001399 EAGR box; Region: EAGR_box; TIGR03834 710127001400 EAGR box; Region: EAGR_box; TIGR03834 710127001401 EAGR box; Region: EAGR_box; TIGR03834 710127001402 EAGR box; Region: EAGR_box; TIGR03834 710127001403 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 710127001404 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 710127001405 ATP binding site [chemical binding]; other site 710127001406 putative Mg++ binding site [ion binding]; other site 710127001407 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710127001408 nucleotide binding region [chemical binding]; other site 710127001409 ATP-binding site [chemical binding]; other site 710127001410 enolase; Provisional; Region: eno; PRK00077 710127001411 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 710127001412 dimer interface [polypeptide binding]; other site 710127001413 metal binding site [ion binding]; metal-binding site 710127001414 substrate binding pocket [chemical binding]; other site 710127001415 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 710127001416 HIT family signature motif; other site 710127001417 catalytic residue [active] 710127001418 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 710127001419 translation elongation factor P; Region: efp; TIGR00038 710127001420 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 710127001421 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 710127001422 RNA binding site [nucleotide binding]; other site 710127001423 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 710127001424 RNA binding site [nucleotide binding]; other site 710127001425 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 710127001426 Walker A/P-loop; other site 710127001427 ATP binding site [chemical binding]; other site 710127001428 Q-loop/lid; other site 710127001429 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 710127001430 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 710127001431 ABC transporter signature motif; other site 710127001432 Walker B; other site 710127001433 D-loop; other site 710127001434 H-loop/switch region; other site 710127001435 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710127001436 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 710127001437 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 710127001438 Walker A/P-loop; other site 710127001439 ATP binding site [chemical binding]; other site 710127001440 Q-loop/lid; other site 710127001441 ABC transporter signature motif; other site 710127001442 Walker B; other site 710127001443 D-loop; other site 710127001444 H-loop/switch region; other site 710127001445 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710127001446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 710127001447 dimer interface [polypeptide binding]; other site 710127001448 conserved gate region; other site 710127001449 putative PBP binding loops; other site 710127001450 ABC-ATPase subunit interface; other site 710127001451 Potential MGA_0224/3 ABC-type dipeptide/oligopeptide/nickel transport system permease protein (DppB/OppB) gene region; MGRL562 710127001452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 710127001453 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710127001454 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 710127001455 Walker A/P-loop; other site 710127001456 ATP binding site [chemical binding]; other site 710127001457 Q-loop/lid; other site 710127001458 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 710127001459 ABC transporter signature motif; other site 710127001460 Walker B; other site 710127001461 D-loop; other site 710127001462 H-loop/switch region; other site 710127001463 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710127001464 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 710127001465 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 710127001466 Walker A/P-loop; other site 710127001467 ATP binding site [chemical binding]; other site 710127001468 Q-loop/lid; other site 710127001469 ABC transporter signature motif; other site 710127001470 Walker B; other site 710127001471 D-loop; other site 710127001472 H-loop/switch region; other site 710127001473 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710127001474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 710127001475 dimer interface [polypeptide binding]; other site 710127001476 conserved gate region; other site 710127001477 putative PBP binding loops; other site 710127001478 ABC-ATPase subunit interface; other site 710127001479 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710127001480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 710127001481 dimer interface [polypeptide binding]; other site 710127001482 conserved gate region; other site 710127001483 putative PBP binding loops; other site 710127001484 ABC-ATPase subunit interface; other site 710127001485 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 710127001486 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 710127001487 rRNA interaction site [nucleotide binding]; other site 710127001488 S8 interaction site; other site 710127001489 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 710127001490 recombination factor protein RarA; Reviewed; Region: PRK13342 710127001491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 710127001492 Walker A motif; other site 710127001493 ATP binding site [chemical binding]; other site 710127001494 Walker B motif; other site 710127001495 arginine finger; other site 710127001496 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 710127001497 Predicted methyltransferases [General function prediction only]; Region: COG0313 710127001498 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 710127001499 Potential MGA_0250 unique hypothetical protein gene region; product in strain R(low) clonal isolate (clone 2) lacks N-terminal 61 amino acids present in other M.gallisepticum isolates including high passage strain R(high); MGRL576 710127001500 OsmC-like protein; Region: OsmC; cl00767 710127001501 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 710127001502 Potential MGA_0258/6 phase-variant protein A (pvpA) gene region; MGRL580 710127001503 elongation factor G; Reviewed; Region: PRK00007 710127001504 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 710127001505 G1 box; other site 710127001506 putative GEF interaction site [polypeptide binding]; other site 710127001507 GTP/Mg2+ binding site [chemical binding]; other site 710127001508 Switch I region; other site 710127001509 G2 box; other site 710127001510 G3 box; other site 710127001511 Switch II region; other site 710127001512 G4 box; other site 710127001513 G5 box; other site 710127001514 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 710127001515 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 710127001516 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 710127001517 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 710127001518 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 710127001519 S17 interaction site [polypeptide binding]; other site 710127001520 S8 interaction site; other site 710127001521 16S rRNA interaction site [nucleotide binding]; other site 710127001522 streptomycin interaction site [chemical binding]; other site 710127001523 23S rRNA interaction site [nucleotide binding]; other site 710127001524 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 710127001525 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 710127001526 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 710127001527 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710127001528 RNA binding surface [nucleotide binding]; other site 710127001529 Domain of unknown function DUF31; Region: DUF31; pfam01732 710127001530 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 710127001531 Predicted integral membrane protein [Function unknown]; Region: COG0392 710127001532 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 710127001533 Ion channel; Region: Ion_trans_2; cl11596 710127001534 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 710127001535 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710127001536 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 710127001537 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cl00164 710127001538 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 710127001539 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting...; Region: ArsC_Spx; cd03032 710127001540 putative catalytic residues [active] 710127001541 thiol/disulfide switch; other site 710127001542 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 710127001543 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 710127001544 active site 710127001545 HIGH motif; other site 710127001546 dimer interface [polypeptide binding]; other site 710127001547 KMSKS motif; other site 710127001548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 710127001549 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 710127001550 active site 710127001551 motif I; other site 710127001552 motif II; other site 710127001553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 710127001554 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 710127001555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 710127001556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 710127001557 cytadherence high molecular weight protein 1 N-terminal region; Region: termin_org_HMW1; TIGR03836 710127001558 EAGR box; Region: EAGR_box; TIGR03834 710127001559 EAGR box; Region: EAGR_box; TIGR03834 710127001560 EAGR box; Region: EAGR_box; TIGR03834 710127001561 terminal organelle assembly protein TopJ; Region: termin_org_DnaJ; TIGR03835 710127001562 EAGR box; Region: EAGR_box; TIGR03834 710127001563 EAGR box; Region: EAGR_box; TIGR03834 710127001564 terminal organelle assembly protein TopJ; Region: termin_org_DnaJ; TIGR03835 710127001565 EAGR box; Region: EAGR_box; TIGR03834 710127001566 EAGR box; Region: EAGR_box; TIGR03834 710127001567 V-type ATP synthase subunit I; Validated; Region: PRK05771 710127001568 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 710127001569 GTP-binding protein LepA; Provisional; Region: PRK05433 710127001570 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 710127001571 G1 box; other site 710127001572 putative GEF interaction site [polypeptide binding]; other site 710127001573 GTP/Mg2+ binding site [chemical binding]; other site 710127001574 Switch I region; other site 710127001575 G2 box; other site 710127001576 G3 box; other site 710127001577 Switch II region; other site 710127001578 G4 box; other site 710127001579 G5 box; other site 710127001580 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 710127001581 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 710127001582 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 710127001583 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 710127001584 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 710127001585 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 710127001586 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 710127001587 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 710127001588 hypothetical protein; Provisional; Region: PRK09609 710127001589 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 710127001590 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 710127001591 Asp-box motif; other site 710127001592 catalytic site [active] 710127001593 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 710127001594 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 710127001595 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 710127001596 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 710127001597 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710127001598 active site 710127001599 HIGH motif; other site 710127001600 nucleotide binding site [chemical binding]; other site 710127001601 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 710127001602 active site 710127001603 KMSKS motif; other site 710127001604 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 710127001605 tRNA binding surface [nucleotide binding]; other site 710127001606 anticodon binding site; other site 710127001607 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 710127001608 G1 box; other site 710127001609 GTP/Mg2+ binding site [chemical binding]; other site 710127001610 Switch I region; other site 710127001611 G2 box; other site 710127001612 G3 box; other site 710127001613 Switch II region; other site 710127001614 G4 box; other site 710127001615 G5 box; other site 710127001616 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 710127001617 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 710127001618 TPP-binding site [chemical binding]; other site 710127001619 transketolase; Reviewed; Region: PRK05899 710127001620 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710127001621 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710127001622 active site 710127001623 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 710127001624 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 710127001625 active site 710127001626 DNA binding site [nucleotide binding] 710127001627 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 710127001628 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in...; Region: TOPRIM_RNase_M5_like; cd01027 710127001629 putative active site [active] 710127001630 putative metal binding site [ion binding]; other site 710127001631 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 710127001632 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 710127001633 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 710127001634 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 710127001635 dimerization interface 3.5A [polypeptide binding]; other site 710127001636 active site 710127001637 Cobalt transport protein; Region: CbiQ; cl00463 710127001638 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13631 710127001639 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 710127001640 Walker A/P-loop; other site 710127001641 ATP binding site [chemical binding]; other site 710127001642 Q-loop/lid; other site 710127001643 ABC transporter signature motif; other site 710127001644 Walker B; other site 710127001645 D-loop; other site 710127001646 H-loop/switch region; other site 710127001647 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 710127001648 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 710127001649 Walker A/P-loop; other site 710127001650 ATP binding site [chemical binding]; other site 710127001651 Q-loop/lid; other site 710127001652 ABC transporter signature motif; other site 710127001653 Walker B; other site 710127001654 D-loop; other site 710127001655 H-loop/switch region; other site 710127001656 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 710127001657 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 710127001658 Sulfatase; Region: Sulfatase; cl10460 710127001659 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 710127001660 substrate binding site [chemical binding]; other site 710127001661 dimer interface [polypeptide binding]; other site 710127001662 catalytic triad [active] 710127001663 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 710127001664 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 710127001665 active site 710127001666 substrate binding site [chemical binding]; other site 710127001667 metal binding site [ion binding]; metal-binding site 710127001668 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 710127001669 active site 710127001670 catalytic motif [active] 710127001671 Zn binding site [ion binding]; other site 710127001672 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 710127001673 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 710127001674 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 710127001675 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 710127001676 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 710127001677 intersubunit interface [polypeptide binding]; other site 710127001678 active site 710127001679 catalytic residue [active] 710127001680 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 710127001681 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 710127001682 TM-ABC transporter signature motif; other site 710127001683 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 710127001684 TM-ABC transporter signature motif; other site 710127001685 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 710127001686 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 710127001687 Walker A/P-loop; other site 710127001688 ATP binding site [chemical binding]; other site 710127001689 Q-loop/lid; other site 710127001690 ABC transporter signature motif; other site 710127001691 Walker B; other site 710127001692 D-loop; other site 710127001693 H-loop/switch region; other site 710127001694 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 710127001695 Potential MGA_0376/7 VlhA.3.0.1 variable lipoprotein family protein gene region; MGRL642 710127001696 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001697 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001698 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001699 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001700 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001701 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001702 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001703 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001704 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001705 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 710127001706 recombination protein RecR; Reviewed; Region: recR; PRK00076 710127001707 RecR protein; Region: RecR; pfam02132 710127001708 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 710127001709 putative active site [active] 710127001710 putative metal-binding site [ion binding]; other site 710127001711 tetramer interface [polypeptide binding]; other site 710127001712 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 710127001713 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05896 710127001714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 710127001715 Walker A motif; other site 710127001716 ATP binding site [chemical binding]; other site 710127001717 Walker B motif; other site 710127001718 arginine finger; other site 710127001719 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 710127001720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 710127001721 Walker A motif; other site 710127001722 ATP binding site [chemical binding]; other site 710127001723 Walker B motif; other site 710127001724 arginine finger; other site 710127001725 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 710127001726 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 710127001727 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 710127001728 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 710127001729 GatB domain; Region: GatB_Yqey; cl11497 710127001730 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 710127001731 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 710127001732 aspartyl/glutamyl-tRNA amidotransferase subunit C-like protein; Provisional; Region: PRK12821 710127001733 hypothetical protein; Provisional; Region: PRK09609 710127001734 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 710127001735 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 710127001736 replicative DNA helicase; Region: DnaB; TIGR00665 710127001737 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 710127001738 Walker A motif; other site 710127001739 ATP binding site [chemical binding]; other site 710127001740 Walker B motif; other site 710127001741 DNA binding loops [nucleotide binding] 710127001742 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 710127001743 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 710127001744 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 710127001745 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 710127001746 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 710127001747 dimer interface [polypeptide binding]; other site 710127001748 ssDNA binding site [nucleotide binding]; other site 710127001749 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710127001750 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 710127001751 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 710127001752 dimer interface [polypeptide binding]; other site 710127001753 active site 710127001754 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 710127001755 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general...; Region: PBEF_like; cd01569 710127001756 active site 710127001757 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710127001758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 710127001759 Mg296 protein; Region: Mg296; pfam09644 710127001760 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 710127001761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 710127001762 active site 710127001763 motif I; other site 710127001764 motif II; other site 710127001765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 710127001766 motif II; other site 710127001767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 710127001768 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 710127001769 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 710127001770 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 710127001771 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 710127001772 GTP/Mg2+ binding site [chemical binding]; other site 710127001773 G4 box; other site 710127001774 G5 box; other site 710127001775 G1 box; other site 710127001776 Switch I region; other site 710127001777 G2 box; other site 710127001778 G3 box; other site 710127001779 Switch II region; other site 710127001780 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 710127001781 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 710127001782 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 710127001783 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 710127001784 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 710127001785 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 710127001786 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 710127001787 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 710127001788 alphaNTD homodimer interface [polypeptide binding]; other site 710127001789 alphaNTD - beta interaction site [polypeptide binding]; other site 710127001790 alphaNTD - beta' interaction site [polypeptide binding]; other site 710127001791 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 710127001792 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 710127001793 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 710127001794 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 710127001795 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 710127001796 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 710127001797 rRNA binding site [nucleotide binding]; other site 710127001798 predicted 30S ribosome binding site; other site 710127001799 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710127001800 catalytic residues [active] 710127001801 DNA topoisomerase I; Validated; Region: PRK05582 710127001802 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 710127001803 active site 710127001804 interdomain interaction site; other site 710127001805 putative metal-binding site [ion binding]; other site 710127001806 nucleotide binding site [chemical binding]; other site 710127001807 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 710127001808 domain I; other site 710127001809 DNA binding groove [nucleotide binding] 710127001810 phosphate binding site [ion binding]; other site 710127001811 domain II; other site 710127001812 domain III; other site 710127001813 nucleotide binding site [chemical binding]; other site 710127001814 catalytic site [active] 710127001815 domain IV; other site 710127001816 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 710127001817 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 710127001818 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 710127001819 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 710127001820 substrate binding site [chemical binding]; other site 710127001821 hexamer interface [polypeptide binding]; other site 710127001822 metal binding site [ion binding]; metal-binding site 710127001823 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 710127001824 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 710127001825 active site 710127001826 dimer interface [polypeptide binding]; other site 710127001827 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 710127001828 dimer interface [polypeptide binding]; other site 710127001829 active site 710127001830 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 710127001831 GTPase/OB domain interface [polypeptide binding]; other site 710127001832 ribosome small subunit-dependent GTPase A; Region: TIGR00157 710127001833 GTPase/Zn-binding domain interface [polypeptide binding]; other site 710127001834 GTP/Mg2+ binding site [chemical binding]; other site 710127001835 G4 box; other site 710127001836 G1 box; other site 710127001837 Switch I region; other site 710127001838 G2 box; other site 710127001839 G3 box; other site 710127001840 Switch II region; other site 710127001841 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710127001842 active site 710127001843 ATP binding site [chemical binding]; other site 710127001844 substrate binding site [chemical binding]; other site 710127001845 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710127001846 activation loop (A-loop); other site 710127001847 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 710127001848 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 710127001849 Active site [active] 710127001850 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 710127001851 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 710127001852 catalytic site [active] 710127001853 G-X2-G-X-G-K; other site 710127001854 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 710127001855 active site 710127001856 catalytic residues [active] 710127001857 metal binding site [ion binding]; metal-binding site 710127001858 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 710127001859 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 710127001860 glucose-inhibited division protein A; Region: gidA; TIGR00136 710127001861 16S rRNA (guanine(527)-N(7))-methyltransferase GidB; Region: gidB; TIGR00138 710127001862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 710127001863 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710127001864 NusG family protein; Region: NusG_myco; TIGR01956 710127001865 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 710127001866 putative homodimer interface [polypeptide binding]; other site 710127001867 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 710127001868 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 710127001869 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710127001870 MULE transposase domain; Region: MULE; pfam10551 710127001871 Protein of unknown function (DUF2714); Region: DUF2714; pfam10896 710127001872 Potential MGA_0485/7 conserved hypothetical gene region; MGRL710 710127001873 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 710127001874 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 710127001875 Walker A motif; other site 710127001876 ATP binding site [chemical binding]; other site 710127001877 Walker B motif; other site 710127001878 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 710127001879 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 710127001880 Walker A motif; other site 710127001881 ATP binding site [chemical binding]; other site 710127001882 Walker B motif; other site 710127001883 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710127001884 Domain of unknown function DUF31; Region: DUF31; pfam01732 710127001885 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 710127001886 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 710127001887 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 710127001888 hypothetical protein; Provisional; Region: PRK08185 710127001889 intersubunit interface [polypeptide binding]; other site 710127001890 active site 710127001891 zinc binding site [ion binding]; other site 710127001892 Na+ binding site [ion binding]; other site 710127001893 GTP-binding protein YchF; Reviewed; Region: PRK09601 710127001894 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 710127001895 G1 box; other site 710127001896 GTP/Mg2+ binding site [chemical binding]; other site 710127001897 Switch I region; other site 710127001898 G2 box; other site 710127001899 Switch II region; other site 710127001900 G3 box; other site 710127001901 G4 box; other site 710127001902 G5 box; other site 710127001903 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 710127001904 Thymidine kinase; Region: TK; cl00631 710127001905 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 710127001906 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 710127001907 23S rRNA interface [nucleotide binding]; other site 710127001908 L7/L12 interface [polypeptide binding]; other site 710127001909 putative thiostrepton binding site; other site 710127001910 L25 interface [polypeptide binding]; other site 710127001911 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 710127001912 mRNA/rRNA interface [nucleotide binding]; other site 710127001913 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 710127001914 putative active site [active] 710127001915 catalytic residue [active] 710127001916 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 710127001917 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 710127001918 Ligand Binding Site [chemical binding]; other site 710127001919 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 710127001920 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 710127001921 active site 710127001922 phosphorylation site [posttranslational modification] 710127001923 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 710127001924 P-loop; other site 710127001925 active site 710127001926 phosphorylation site [posttranslational modification] 710127001927 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 710127001928 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 710127001929 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 710127001930 Potential MGA_0518/7 Subtilisin-like serine protease gene region; MGRL727 710127001931 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710127001932 active site 710127001933 catalytic residues [active] 710127001934 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 710127001935 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 710127001936 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 710127001937 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 710127001938 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 710127001939 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 710127001940 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 710127001941 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 710127001942 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 710127001943 active site 710127001944 HIGH motif; other site 710127001945 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 710127001946 KMSKS motif; other site 710127001947 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 710127001948 active site 710127001949 catalytic triad [active] 710127001950 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710127001951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 710127001952 Walker A motif; other site 710127001953 ATP binding site [chemical binding]; other site 710127001954 Walker B motif; other site 710127001955 arginine finger; other site 710127001956 HsdM N-terminal domain; Region: HsdM_N; pfam12161 710127001957 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 710127001958 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 710127001959 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 710127001960 Potential MGA_0539/40 type I restriction-modification system specificity (S) subunit gene region.; MGRL737f 710127001961 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 710127001962 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 710127001963 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 710127001964 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 710127001965 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710127001966 ATP binding site [chemical binding]; other site 710127001967 putative Mg++ binding site [ion binding]; other site 710127001968 Herpesvirus UL31-like protein; Region: Herpes_UL31; pfam02718 710127001969 Region encodes amino acid sequences similar to N-terminal regions of conserved hypothetical proteins predicted in M. synoviae 710127001970 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 710127001971 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 710127001972 nucleotide binding pocket [chemical binding]; other site 710127001973 K-X-D-G motif; other site 710127001974 catalytic site [active] 710127001975 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 710127001976 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 710127001977 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 710127001978 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 710127001979 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 710127001980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710127001981 ATP binding site [chemical binding]; other site 710127001982 putative Mg++ binding site [ion binding]; other site 710127001983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710127001984 nucleotide binding region [chemical binding]; other site 710127001985 ATP-binding site [chemical binding]; other site 710127001986 Potential MGA_0578 conserved hypothetical protein gene region; MGRL763 710127001987 Domain of unknown function DUF31; Region: DUF31; pfam01732 710127001988 Potential MGA_0584/3 conserved hypothetical protein gene region; MGRL766 710127001989 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 710127001990 NAD(P) binding site [chemical binding]; other site 710127001991 catalytic residues [active] 710127001992 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 710127001993 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710127001994 Zn2+ binding site [ion binding]; other site 710127001995 Mg2+ binding site [ion binding]; other site 710127001996 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 710127001997 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 710127001998 HIGH motif; other site 710127001999 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 710127002000 active site 710127002001 KMSKS motif; other site 710127002002 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 710127002003 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 710127002004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710127002005 NAD(P) binding pocket [chemical binding]; other site 710127002006 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 710127002007 HPr kinase/phosphorylase; Provisional; Region: PRK05428 710127002008 DRTGG domain; Region: DRTGG; cl12147 710127002009 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 710127002010 Hpr binding site; other site 710127002011 active site 710127002012 homohexamer subunit interaction site [polypeptide binding]; other site 710127002013 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 710127002014 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 710127002015 active site 710127002016 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 710127002017 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 710127002018 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 710127002019 G1 box; other site 710127002020 GTP/Mg2+ binding site [chemical binding]; other site 710127002021 Switch I region; other site 710127002022 G2 box; other site 710127002023 Switch II region; other site 710127002024 G3 box; other site 710127002025 G4 box; other site 710127002026 G5 box; other site 710127002027 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 710127002028 DNA polymerase III subunit delta'; Validated; Region: PRK05818 710127002029 thymidylate kinase; Validated; Region: tmk; PRK00698 710127002030 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 710127002031 TMP-binding site; other site 710127002032 ATP-binding site [chemical binding]; other site 710127002033 seryl-tRNA synthetase; Provisional; Region: PRK05431 710127002034 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 710127002035 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 710127002036 dimer interface [polypeptide binding]; other site 710127002037 active site 710127002038 motif 1; other site 710127002039 motif 2; other site 710127002040 motif 3; other site 710127002041 DNA gyrase subunit A; Validated; Region: PRK05560 710127002042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 710127002043 CAP-like domain; other site 710127002044 Active site [active] 710127002045 primary dimer interface [polypeptide binding]; other site 710127002046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710127002047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710127002048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710127002049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710127002050 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 710127002051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710127002052 ATP binding site [chemical binding]; other site 710127002053 Mg2+ binding site [ion binding]; other site 710127002054 G-X-G motif; other site 710127002055 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 710127002056 anchoring element; other site 710127002057 dimer interface [polypeptide binding]; other site 710127002058 ATP binding site [chemical binding]; other site 710127002059 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 710127002060 active site 710127002061 putative metal-binding site [ion binding]; other site 710127002062 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 710127002063 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 710127002064 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 710127002065 HSP70 interaction site [polypeptide binding]; other site 710127002066 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cl02940 710127002067 putative DNA binding surface [nucleotide binding]; other site 710127002068 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 710127002069 dimer interface [polypeptide binding]; other site 710127002070 beta-clamp/clamp loader binding surface; other site 710127002071 beta-clamp/translesion DNA polymerase binding surface; other site