-- dump date   	20111121_013431
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
267748000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
267748000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
267748000003	Walker A motif; other site
267748000004	ATP binding site [chemical binding]; other site
267748000005	Walker B motif; other site
267748000006	arginine finger; other site
267748000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
267748000008	DnaA box-binding interface [nucleotide binding]; other site
267748000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
267748000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140
267748000011	putative DNA binding surface [nucleotide binding]; other site
267748000012	dimer interface [polypeptide binding]; other site
267748000013	beta-clamp/clamp loader binding surface; other site
267748000014	beta-clamp/translesion DNA polymerase binding surface; other site
267748000015	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
267748000016	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
267748000017	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
267748000018	HIGH motif; other site
267748000019	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
267748000020	active site
267748000021	KMSKS motif; other site
267748000022	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
267748000023	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
267748000024	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
267748000025	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
267748000026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
267748000027	dimer interface [polypeptide binding]; other site
267748000028	conserved gate region; other site
267748000029	ABC-ATPase subunit interface; other site
267748000030	phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972
267748000031	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
267748000032	Walker A/P-loop; other site
267748000033	ATP binding site [chemical binding]; other site
267748000034	Q-loop/lid; other site
267748000035	ABC transporter signature motif; other site
267748000036	Walker B; other site
267748000037	D-loop; other site
267748000038	H-loop/switch region; other site
267748000039	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
267748000040	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
267748000041	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
267748000042	TM-ABC transporter signature motif; other site
267748000043	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
267748000044	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
267748000045	Walker A/P-loop; other site
267748000046	ATP binding site [chemical binding]; other site
267748000047	Q-loop/lid; other site
267748000048	ABC transporter signature motif; other site
267748000049	Walker B; other site
267748000050	D-loop; other site
267748000051	H-loop/switch region; other site
267748000052	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
267748000053	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
267748000054	putative ligand binding site [chemical binding]; other site
267748000055	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115
267748000056	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
267748000057	active site
267748000058	dimer interface [polypeptide binding]; other site
267748000059	effector binding site; other site
267748000060	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
267748000061	Walker A motif; other site
267748000062	ATP binding site [chemical binding]; other site
267748000063	Walker B motif; other site
267748000064	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
267748000065	inhibitor binding site; inhibition site
267748000066	catalytic motif [active]
267748000067	Catalytic residue [active]
267748000068	Active site flap [active]
267748000069	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
267748000070	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083
267748000071	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
267748000072	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
267748000073	dimerization interface [polypeptide binding]; other site
267748000074	active site
267748000075	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209
267748000076	folate binding site [chemical binding]; other site
267748000077	NADP+ binding site [chemical binding]; other site
267748000078	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
267748000079	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
267748000080	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
267748000081	Walker A/P-loop; other site
267748000082	ATP binding site [chemical binding]; other site
267748000083	Q-loop/lid; other site
267748000084	ABC transporter signature motif; other site
267748000085	Walker B; other site
267748000086	D-loop; other site
267748000087	H-loop/switch region; other site
267748000088	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
267748000089	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
267748000090	TM-ABC transporter signature motif; other site
267748000091	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
267748000092	TM-ABC transporter signature motif; other site
267748000093	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
267748000094	tetramer (dimer of dimers) interface [polypeptide binding]; other site
267748000095	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
267748000096	NAD binding site [chemical binding]; other site
267748000097	dimer interface [polypeptide binding]; other site
267748000098	substrate binding site [chemical binding]; other site
267748000099	Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672
267748000100	Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672
267748000101	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
267748000102	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322
267748000103	dimer interface [polypeptide binding]; other site
267748000104	putative anticodon binding site; other site
267748000105	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
267748000106	motif 1; other site
267748000107	active site
267748000108	motif 2; other site
267748000109	motif 3; other site
267748000110	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
267748000111	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
267748000112	active site
267748000113	motif I; other site
267748000114	motif II; other site
267748000115	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
267748000116	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
267748000117	active site
267748000118	motif I; other site
267748000119	motif II; other site
267748000120	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
267748000121	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
267748000122	active site
267748000123	motif I; other site
267748000124	motif II; other site
267748000125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
267748000126	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
267748000127	Walker A/P-loop; other site
267748000128	ATP binding site [chemical binding]; other site
267748000129	Q-loop/lid; other site
267748000130	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
267748000131	ABC transporter signature motif; other site
267748000132	Walker B; other site
267748000133	D-loop; other site
267748000134	H-loop/switch region; other site
267748000135	TOBE domain; Region: TOBE_2; cl01440
267748000136	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
267748000137	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
267748000138	dimer interface [polypeptide binding]; other site
267748000139	conserved gate region; other site
267748000140	putative PBP binding loops; other site
267748000141	ABC-ATPase subunit interface; other site
267748000142	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
267748000143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
267748000144	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
267748000145	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
267748000146	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
267748000147	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
267748000148	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254
267748000149	putative nucleotide binding site [chemical binding]; other site
267748000150	uridine monophosphate binding site [chemical binding]; other site
267748000151	homohexameric interface [polypeptide binding]; other site
267748000152	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
267748000153	hinge region; other site
267748000154	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
267748000155	DNA polymerase III PolC; Validated; Region: polC; PRK00448
267748000156	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
267748000157	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
267748000158	generic binding surface II; other site
267748000159	generic binding surface I; other site
267748000160	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
267748000161	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
267748000162	active site
267748000163	substrate binding site [chemical binding]; other site
267748000164	catalytic site [active]
267748000165	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
267748000166	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
267748000167	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
267748000168	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
267748000169	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
267748000170	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
267748000171	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
267748000172	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
267748000173	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
267748000174	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212
267748000175	active site turn [active]
267748000176	phosphorylation site [posttranslational modification]
267748000177	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
267748000178	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
267748000179	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
267748000180	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162
267748000181	HPr interaction site; other site
267748000182	glycerol kinase (GK) interaction site [polypeptide binding]; other site
267748000183	active site
267748000184	phosphorylation site [posttranslational modification]
267748000185	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
267748000186	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
267748000187	DHH family; Region: DHH; pfam01368
267748000188	DHHA1 domain; Region: DHHA1; pfam02272
267748000189	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803
267748000190	active site
267748000191	FMN binding site [chemical binding]; other site
267748000192	substrate binding site [chemical binding]; other site
267748000193	putative catalytic residue [active]
267748000194	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
267748000195	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
267748000196	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
267748000197	RNA binding surface [nucleotide binding]; other site
267748000198	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
267748000199	THUMP domain; Region: THUMP; cl12076
267748000200	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
267748000201	Ligand Binding Site [chemical binding]; other site
267748000202	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
267748000203	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07133
267748000204	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
267748000205	Walker A motif; other site
267748000206	ATP binding site [chemical binding]; other site
267748000207	Walker B motif; other site
267748000208	Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494
267748000209	recombination protein RecR; Reviewed; Region: recR; PRK00076
267748000210	RecR protein; Region: RecR; pfam02132
267748000211	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
267748000212	putative active site [active]
267748000213	putative metal-binding site [ion binding]; other site
267748000214	tetramer interface [polypeptide binding]; other site
267748000215	thymidylate kinase; Validated; Region: tmk; PRK00698
267748000216	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672
267748000217	TMP-binding site; other site
267748000218	ATP-binding site [chemical binding]; other site
267748000219	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
267748000220	trimerization site [polypeptide binding]; other site
267748000221	active site
267748000222	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
267748000223	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
267748000224	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
267748000225	catalytic residue [active]
267748000226	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
267748000227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
267748000228	DNA topoisomerase I; Validated; Region: PRK05582
267748000229	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363
267748000230	active site
267748000231	interdomain interaction site; other site
267748000232	putative metal-binding site [ion binding]; other site
267748000233	nucleotide binding site [chemical binding]; other site
267748000234	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
267748000235	domain I; other site
267748000236	DNA binding groove [nucleotide binding]
267748000237	phosphate binding site [ion binding]; other site
267748000238	domain II; other site
267748000239	domain III; other site
267748000240	nucleotide binding site [chemical binding]; other site
267748000241	catalytic site [active]
267748000242	domain IV; other site
267748000243	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
267748000244	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
267748000245	substrate binding site [chemical binding]; other site
267748000246	Protein of unknown function (DUF3196); Region: DUF3196; pfam11428
267748000247	trigger factor; Region: tig; TIGR00115
267748000248	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
267748000249	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
267748000250	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903
267748000251	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
267748000252	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228
267748000253	nucleotide binding site/active site [active]
267748000254	HIT family signature motif; other site
267748000255	catalytic residue [active]
267748000256	seryl-tRNA synthetase; Provisional; Region: PRK05431
267748000257	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
267748000258	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
267748000259	dimer interface [polypeptide binding]; other site
267748000260	active site
267748000261	motif 1; other site
267748000262	motif 2; other site
267748000263	motif 3; other site
267748000264	RecD/TraA family; Region: recD_rel; TIGR01448
267748000265	UvrD/REP helicase; Region: UvrD-helicase; cl14126
267748000266	Predicted RNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG2263
267748000267	RecD/TraA family; Region: recD_rel; TIGR01448
267748000268	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
267748000269	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
267748000270	putative active site [active]
267748000271	putative metal binding site [ion binding]; other site
267748000272	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
267748000273	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
267748000274	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222
267748000275	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
267748000276	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
267748000277	NAD(P) binding pocket [chemical binding]; other site
267748000278	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
267748000279	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
267748000280	ATP binding site [chemical binding]; other site
267748000281	Mg2+ binding site [ion binding]; other site
267748000282	G-X-G motif; other site
267748000283	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
267748000284	anchoring element; other site
267748000285	dimer interface [polypeptide binding]; other site
267748000286	ATP binding site [chemical binding]; other site
267748000287	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
267748000288	active site
267748000289	putative metal-binding site [ion binding]; other site
267748000290	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
267748000291	SdiA-regulated; Region: SdiA-regulated; cl06158
267748000292	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
267748000293	HrcA protein C terminal domain; Region: HrcA; pfam01628
267748000294	trigger factor; Region: tig; TIGR00115
267748000295	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446
267748000296	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
267748000297	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
267748000298	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
267748000299	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
267748000300	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
267748000301	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
267748000302	active site
267748000303	tetramer interface [polypeptide binding]; other site
267748000304	Domain of unknown function (DUF205); Region: DUF205; cl00410
267748000305	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
267748000306	YlqF.  Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856
267748000307	GTP/Mg2+ binding site [chemical binding]; other site
267748000308	G4 box; other site
267748000309	G5 box; other site
267748000310	G1 box; other site
267748000311	Switch I region; other site
267748000312	G2 box; other site
267748000313	G3 box; other site
267748000314	Switch II region; other site
267748000315	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
267748000316	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
267748000317	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
267748000318	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
267748000319	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
267748000320	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
267748000321	active site
267748000322	motif I; other site
267748000323	motif II; other site
267748000324	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
267748000325	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
267748000326	RNA/DNA hybrid binding site [nucleotide binding]; other site
267748000327	active site
267748000328	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
267748000329	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
267748000330	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
267748000331	active site
267748000332	HIGH motif; other site
267748000333	KMSK motif region; other site
267748000334	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
267748000335	tRNA binding surface [nucleotide binding]; other site
267748000336	anticodon binding site; other site
267748000337	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947
267748000338	hypothetical protein; Provisional; Region: PRK08185
267748000339	intersubunit interface [polypeptide binding]; other site
267748000340	active site
267748000341	zinc binding site [ion binding]; other site
267748000342	Na+ binding site [ion binding]; other site
267748000343	Staphylococcal nuclease homologues; Region: SNc; smart00318
267748000344	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
267748000345	Catalytic site; other site
267748000346	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
267748000347	UGMP family protein; Validated; Region: PRK09604
267748000348	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
267748000349	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
267748000350	Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520
267748000351	Ion channel; Region: Ion_trans_2; cl11596
267748000352	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
267748000353	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
267748000354	P loop; other site
267748000355	GTP binding site [chemical binding]; other site
267748000356	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403
267748000357	mRNA/rRNA interface [nucleotide binding]; other site
267748000358	50S ribosomal protein L11/unknown domain fusion protein; Provisional; Region: PRK14539
267748000359	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
267748000360	23S rRNA interface [nucleotide binding]; other site
267748000361	L7/L12 interface [polypeptide binding]; other site
267748000362	putative thiostrepton binding site; other site
267748000363	L25 interface [polypeptide binding]; other site
267748000364	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
267748000365	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
267748000366	catalytic residues [active]
267748000367	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
267748000368	catalytic residues [active]
267748000369	prolyl-tRNA synthetase; Provisional; Region: PRK08661
267748000370	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_arch_euk; cd00778
267748000371	dimer interface [polypeptide binding]; other site
267748000372	motif 1; other site
267748000373	active site
267748000374	motif 2; other site
267748000375	motif 3; other site
267748000376	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity...; Region: ProRS_anticodon_zinc; cd00862
267748000377	anticodon binding site; other site
267748000378	zinc-binding site [ion binding]; other site
267748000379	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
267748000380	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
267748000381	putative homodimer interface [polypeptide binding]; other site
267748000382	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
267748000383	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
267748000384	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
267748000385	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
267748000386	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
267748000387	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
267748000388	active site
267748000389	HIGH motif; other site
267748000390	nucleotide binding site [chemical binding]; other site
267748000391	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
267748000392	active site
267748000393	KMSKS motif; other site
267748000394	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
267748000395	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
267748000396	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455
267748000397	RNA binding site [nucleotide binding]; other site
267748000398	homodimer interface [polypeptide binding]; other site
267748000399	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
267748000400	G-X-X-G motif; other site
267748000401	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
267748000402	putative RNA binding cleft [nucleotide binding]; other site
267748000403	translation initiation factor IF-2; Region: IF-2; TIGR00487
267748000404	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
267748000405	IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily.  IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits.  As seen in other GTPases...; Region: IF2_eIF5B; cd01887
267748000406	G1 box; other site
267748000407	putative GEF interaction site [polypeptide binding]; other site
267748000408	GTP/Mg2+ binding site [chemical binding]; other site
267748000409	Switch I region; other site
267748000410	G2 box; other site
267748000411	G3 box; other site
267748000412	Switch II region; other site
267748000413	G4 box; other site
267748000414	G5 box; other site
267748000415	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702
267748000416	Translation-initiation factor 2; Region: IF-2; pfam11987
267748000417	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692
267748000418	Ribosome-binding factor A; Region: RBFA; cl00542
267748000419	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520
267748000420	Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445
267748000421	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679
267748000422	hypothetical protein; Provisional; Region: PRK09609
267748000423	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
267748000424	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
267748000425	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
267748000426	active site
267748000427	HIGH motif; other site
267748000428	nucleotide binding site [chemical binding]; other site
267748000429	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
267748000430	active site
267748000431	KMSKS motif; other site
267748000432	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
267748000433	tRNA binding surface [nucleotide binding]; other site
267748000434	anticodon binding site; other site
267748000435	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
267748000436	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
267748000437	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
267748000438	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
267748000439	homodimer interface [polypeptide binding]; other site
267748000440	NADP binding site [chemical binding]; other site
267748000441	substrate binding site [chemical binding]; other site
267748000442	F0F1-type ATP synthase, alpha subunit [Energy production and conversion]; Region: AtpA; COG0056
267748000443	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
267748000444	Walker A motif; other site
267748000445	ATP binding site [chemical binding]; other site
267748000446	Walker B motif; other site
267748000447	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
267748000448	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
267748000449	alpha subunit interaction interface [polypeptide binding]; other site
267748000450	Walker A motif; other site
267748000451	ATP binding site [chemical binding]; other site
267748000452	Walker B motif; other site
267748000453	inhibitor binding site; inhibition site
267748000454	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
267748000455	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
267748000456	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
267748000457	Acetokinase family; Region: Acetate_kinase; cl01029
267748000458	Uncharacterized conserved protein [Function unknown]; Region: COG1284
267748000459	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
267748000460	replicative DNA helicase; Region: DnaB; TIGR00665
267748000461	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
267748000462	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
267748000463	Walker A motif; other site
267748000464	ATP binding site [chemical binding]; other site
267748000465	Walker B motif; other site
267748000466	DNA binding loops [nucleotide binding]
267748000467	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
267748000468	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
267748000469	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
267748000470	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
267748000471	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
267748000472	DHH family; Region: DHH; pfam01368
267748000473	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433
267748000474	interface (dimer of trimers) [polypeptide binding]; other site
267748000475	Substrate-binding/catalytic site; other site
267748000476	Zn-binding sites [ion binding]; other site
267748000477	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
267748000478	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
267748000479	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
267748000480	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
267748000481	rRNA interaction site [nucleotide binding]; other site
267748000482	S8 interaction site; other site
267748000483	putative laminin-1 binding site; other site
267748000484	elongation factor Ts; Provisional; Region: tsf; PRK09377
267748000485	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
267748000486	Elongation factor TS; Region: EF_TS; pfam00889
267748000487	Elongation factor TS; Region: EF_TS; pfam00889
267748000488	Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577
267748000489	Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577
267748000490	enolase; Provisional; Region: eno; PRK00077
267748000491	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
267748000492	dimer interface [polypeptide binding]; other site
267748000493	metal binding site [ion binding]; metal-binding site
267748000494	substrate binding pocket [chemical binding]; other site
267748000495	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
267748000496	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
267748000497	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
267748000498	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
267748000499	HPr kinase/phosphorylase; Provisional; Region: PRK05428
267748000500	DRTGG domain; Region: DRTGG; cl12147
267748000501	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918
267748000502	Hpr binding site; other site
267748000503	active site
267748000504	homohexamer subunit interaction site [polypeptide binding]; other site
267748000505	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
267748000506	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
267748000507	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
267748000508	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
267748000509	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
267748000510	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
267748000511	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
267748000512	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
267748000513	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
267748000514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
267748000515	S-adenosylmethionine binding site [chemical binding]; other site
267748000516	peptide chain release factor 1; Validated; Region: prfA; PRK00591
267748000517	RF-1 domain; Region: RF-1; cl02875
267748000518	RF-1 domain; Region: RF-1; cl02875
267748000519	Domain of unknown function DUF28; Region: DUF28; cl00361
267748000520	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
267748000521	Ligand Binding Site [chemical binding]; other site
267748000522	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
267748000523	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
267748000524	NAD binding site [chemical binding]; other site
267748000525	homodimer interface [polypeptide binding]; other site
267748000526	active site
267748000527	substrate binding site [chemical binding]; other site
267748000528	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
267748000529	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
267748000530	nucleotide binding pocket [chemical binding]; other site
267748000531	K-X-D-G motif; other site
267748000532	catalytic site [active]
267748000533	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
267748000534	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
267748000535	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
267748000536	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cl00038
267748000537	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
267748000538	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
267748000539	Walker A/P-loop; other site
267748000540	ATP binding site [chemical binding]; other site
267748000541	Q-loop/lid; other site
267748000542	ABC transporter signature motif; other site
267748000543	Walker B; other site
267748000544	D-loop; other site
267748000545	H-loop/switch region; other site
267748000546	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
267748000547	oligoendopeptidase F; Region: pepF; TIGR00181
267748000548	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
267748000549	active site
267748000550	Zn binding site [ion binding]; other site
267748000551	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
267748000552	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cd00741
267748000553	nucleophilic elbow; other site
267748000554	catalytic triad; other site
267748000555	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408
267748000556	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799
267748000557	active site
267748000558	substrate binding site [chemical binding]; other site
267748000559	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
267748000560	metal binding site [ion binding]; metal-binding site
267748000561	Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219
267748000562	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
267748000563	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
267748000564	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
267748000565	active site
267748000566	catalytic site [active]
267748000567	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
267748000568	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
267748000569	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
267748000570	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
267748000571	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
267748000572	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
267748000573	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
267748000574	alpha subunit interaction interface [polypeptide binding]; other site
267748000575	Walker A motif; other site
267748000576	ATP binding site [chemical binding]; other site
267748000577	Walker B motif; other site
267748000578	inhibitor binding site; inhibition site
267748000579	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
267748000580	ATP synthase; Region: ATP-synt; cl00365
267748000581	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
267748000582	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
267748000583	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
267748000584	beta subunit interaction interface [polypeptide binding]; other site
267748000585	Walker A motif; other site
267748000586	ATP binding site [chemical binding]; other site
267748000587	Walker B motif; other site
267748000588	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
267748000589	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
267748000590	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
267748000591	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
267748000592	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
267748000593	ATP synthase subunit C; Region: ATP-synt_C; cl00466
267748000594	ATP synthase A chain; Region: ATP-synt_A; cl00413
267748000595	Phosphopantetheine attachment site; Region: PP-binding; cl09936
267748000596	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
267748000597	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
267748000598	Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235
267748000599	Amidinotransferase; Region: Amidinotransf; cl12043
267748000600	elongation factor Tu; Reviewed; Region: PRK12736
267748000601	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
267748000602	G1 box; other site
267748000603	GEF interaction site [polypeptide binding]; other site
267748000604	GTP/Mg2+ binding site [chemical binding]; other site
267748000605	Switch I region; other site
267748000606	G2 box; other site
267748000607	G3 box; other site
267748000608	Switch II region; other site
267748000609	G4 box; other site
267748000610	G5 box; other site
267748000611	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
267748000612	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
267748000613	Antibiotic Binding Site [chemical binding]; other site
267748000614	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
267748000615	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
267748000616	dimer interface [polypeptide binding]; other site
267748000617	ssDNA binding site [nucleotide binding]; other site
267748000618	tetramer (dimer of dimers) interface [polypeptide binding]; other site
267748000619	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
267748000620	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
267748000621	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
267748000622	23S rRNA interface [nucleotide binding]; other site
267748000623	L3 interface [polypeptide binding]; other site
267748000624	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
267748000625	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
267748000626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
267748000627	SelR domain; Region: SelR; cl00369
267748000628	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
267748000629	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
267748000630	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
267748000631	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
267748000632	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
267748000633	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
267748000634	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
267748000635	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
267748000636	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
267748000637	putative translocon binding site; other site
267748000638	protein-rRNA interface [nucleotide binding]; other site
267748000639	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
267748000640	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The...; Region: 30S_S3_KH; cd02412
267748000641	G-X-X-G motif; other site
267748000642	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
267748000643	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
267748000644	23S rRNA interface [nucleotide binding]; other site
267748000645	5S rRNA interface [nucleotide binding]; other site
267748000646	putative antibiotic binding site [chemical binding]; other site
267748000647	L25 interface [polypeptide binding]; other site
267748000648	L27 interface [polypeptide binding]; other site
267748000649	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427
267748000650	23S rRNA interface [nucleotide binding]; other site
267748000651	putative translocon interaction site; other site
267748000652	signal recognition particle (SRP54) interaction site; other site
267748000653	L23 interface [polypeptide binding]; other site
267748000654	trigger factor interaction site; other site
267748000655	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
267748000656	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
267748000657	KOW motif; Region: KOW; cl00354
267748000658	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
267748000659	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
267748000660	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
267748000661	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
267748000662	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
267748000663	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
267748000664	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
267748000665	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
267748000666	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
267748000667	23S rRNA interface [nucleotide binding]; other site
267748000668	L21e interface [polypeptide binding]; other site
267748000669	5S rRNA interface [nucleotide binding]; other site
267748000670	L27 interface [polypeptide binding]; other site
267748000671	L5 interface [polypeptide binding]; other site
267748000672	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
267748000673	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
267748000674	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
267748000675	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
267748000676	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
267748000677	SecY translocase; Region: SecY; pfam00344
267748000678	adenylate kinases; Region: adk; TIGR01351
267748000679	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
267748000680	AMP-binding site [chemical binding]; other site
267748000681	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
267748000682	methionine aminopeptidase; Reviewed; Region: PRK07281
267748000683	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
267748000684	active site
267748000685	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
267748000686	rRNA binding site [nucleotide binding]; other site
267748000687	predicted 30S ribosome binding site; other site
267748000688	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
267748000689	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
267748000690	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
267748000691	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
267748000692	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
267748000693	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
267748000694	alphaNTD - beta interaction site [polypeptide binding]; other site
267748000695	alphaNTD homodimer interface [polypeptide binding]; other site
267748000696	alphaNTD - beta' interaction site [polypeptide binding]; other site
267748000697	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
267748000698	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
267748000699	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
267748000700	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799
267748000701	active site
267748000702	substrate binding site [chemical binding]; other site
267748000703	metal binding site [ion binding]; metal-binding site
267748000704	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
267748000705	SmpB-tmRNA interface; other site
267748000706	ribonuclease R; Region: RNase_R; TIGR02063
267748000707	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
267748000708	RNB domain; Region: RNB; pfam00773
267748000709	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
267748000710	RNA binding site [nucleotide binding]; other site
267748000711	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
267748000712	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
267748000713	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
267748000714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
267748000715	Walker A motif; other site
267748000716	ATP binding site [chemical binding]; other site
267748000717	Walker B motif; other site
267748000718	arginine finger; other site
267748000719	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
267748000720	Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508
267748000721	dUTPase; Region: dUTPase_2; pfam08761
267748000722	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
267748000723	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
267748000724	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
267748000725	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
267748000726	Walker A motif; other site
267748000727	ATP binding site [chemical binding]; other site
267748000728	Walker B motif; other site
267748000729	arginine finger; other site
267748000730	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
267748000731	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
267748000732	Protein export membrane protein; Region: SecD_SecF; cl14618
267748000733	histidyl-tRNA synthetase; Region: hisS; TIGR00442
267748000734	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
267748000735	dimer interface [polypeptide binding]; other site
267748000736	motif 1; other site
267748000737	active site
267748000738	motif 2; other site
267748000739	motif 3; other site
267748000740	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
267748000741	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
267748000742	dimer interface [polypeptide binding]; other site
267748000743	anticodon binding site; other site
267748000744	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
267748000745	motif 1; other site
267748000746	dimer interface [polypeptide binding]; other site
267748000747	active site
267748000748	motif 2; other site
267748000749	GAD domain; Region: GAD; pfam02938
267748000750	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
267748000751	active site
267748000752	motif 3; other site
267748000753	DNA polymerase IV; Validated; Region: PRK01810
267748000754	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
267748000755	active site
267748000756	DNA binding site [nucleotide binding]
267748000757	putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152
267748000758	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
267748000759	active site
267748000760	(T/H)XGH motif; other site
267748000761	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
267748000762	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164
267748000763	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
267748000764	TraX protein; Region: TraX; cl05434
267748000765	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
267748000766	dimer interface [polypeptide binding]; other site
267748000767	catalytic triad [active]
267748000768	peroxidatic and resolving cysteines [active]
267748000769	DEAD-like helicases superfamily; Region: DEXDc; smart00487
267748000770	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
267748000771	ATP binding site [chemical binding]; other site
267748000772	putative Mg++ binding site [ion binding]; other site
267748000773	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
267748000774	nucleotide binding region [chemical binding]; other site
267748000775	ATP-binding site [chemical binding]; other site
267748000776	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
267748000777	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591
267748000778	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
267748000779	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
267748000780	RPB1 interaction site [polypeptide binding]; other site
267748000781	RPB10 interaction site [polypeptide binding]; other site
267748000782	RPB11 interaction site [polypeptide binding]; other site
267748000783	RPB3 interaction site [polypeptide binding]; other site
267748000784	RPB12 interaction site [polypeptide binding]; other site
267748000785	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
267748000786	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
267748000787	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
267748000788	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
267748000789	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
267748000790	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
267748000791	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
267748000792	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
267748000793	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
267748000794	DNA binding site [nucleotide binding]
267748000795	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
267748000796	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
267748000797	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
267748000798	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
267748000799	ATP binding site [chemical binding]; other site
267748000800	putative Mg++ binding site [ion binding]; other site
267748000801	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
267748000802	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
267748000803	HsdM N-terminal domain; Region: HsdM_N; pfam12161
267748000804	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
267748000805	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
267748000806	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
267748000807	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
267748000808	HsdM N-terminal domain; Region: HsdM_N; pfam12161
267748000809	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
267748000810	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
267748000811	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
267748000812	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
267748000813	Uncharacterized conserved protein [Function unknown]; Region: COG0327
267748000814	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309
267748000815	RNA polymerase sigma factor; Provisional; Region: PRK05901
267748000816	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
267748000817	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
267748000818	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
267748000819	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
267748000820	DNA primase, catalytic core; Region: dnaG; TIGR01391
267748000821	CHC2 zinc finger; Region: zf-CHC2; cl02597
267748000822	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
267748000823	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
267748000824	active site
267748000825	metal binding site [ion binding]; metal-binding site
267748000826	interdomain interaction site; other site
267748000827	glycyl-tRNA synthetase; Provisional; Region: PRK04173
267748000828	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
267748000829	motif 1; other site
267748000830	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774
267748000831	active site
267748000832	motif 2; other site
267748000833	motif 3; other site
267748000834	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266
267748000835	anticodon binding site; other site
267748000836	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200
267748000837	amphipathic channel; other site
267748000838	Asn-Pro-Ala signature motifs; other site
267748000839	glycerol kinase; Provisional; Region: glpK; PRK00047
267748000840	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
267748000841	FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782
267748000842	FAD dependent oxidoreductase; Region: DAO; pfam01266
267748000843	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
267748000844	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
267748000845	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
267748000846	alpha subunit interaction interface [polypeptide binding]; other site
267748000847	Walker A motif; other site
267748000848	ATP binding site [chemical binding]; other site
267748000849	Walker B motif; other site
267748000850	inhibitor binding site; inhibition site
267748000851	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
267748000852	F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165
267748000853	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
267748000854	Walker A motif; other site
267748000855	ATP binding site [chemical binding]; other site
267748000856	Walker B motif; other site
267748000857	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
267748000858	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
267748000859	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
267748000860	Domain of unknown function(DUF2779); Region: DUF2779; pfam11074
267748000861	S-adenosylmethionine synthetase; Validated; Region: PRK05250
267748000862	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
267748000863	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
267748000864	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
267748000865	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
267748000866	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl12019
267748000867	active site
267748000868	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
267748000869	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
267748000870	ATP binding site [chemical binding]; other site
267748000871	putative Mg++ binding site [ion binding]; other site
267748000872	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
267748000873	nucleotide binding region [chemical binding]; other site
267748000874	ATP-binding site [chemical binding]; other site
267748000875	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
267748000876	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
267748000877	active site
267748000878	HIGH motif; other site
267748000879	KMSKS motif; other site
267748000880	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
267748000881	tRNA binding surface [nucleotide binding]; other site
267748000882	anticodon binding site; other site
267748000883	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
267748000884	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
267748000885	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
267748000886	dimer interface [polypeptide binding]; other site
267748000887	motif 1; other site
267748000888	active site
267748000889	motif 2; other site
267748000890	motif 3; other site
267748000891	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
267748000892	Sulfatase; Region: Sulfatase; cl10460
267748000893	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
267748000894	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204
267748000895	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
267748000896	active site
267748000897	ADP/pyrophosphate binding site [chemical binding]; other site
267748000898	dimerization interface [polypeptide binding]; other site
267748000899	allosteric effector site; other site
267748000900	fructose-1,6-bisphosphate binding site; other site
267748000901	pyruvate kinase; Provisional; Region: PRK05826
267748000902	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
267748000903	domain interfaces; other site
267748000904	active site
267748000905	Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200
267748000906	Predicted ATPase [General function prediction only]; Region: COG4637
267748000907	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
267748000908	Walker A/P-loop; other site
267748000909	ATP binding site [chemical binding]; other site
267748000910	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903
267748000911	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
267748000912	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
267748000913	RNA binding surface [nucleotide binding]; other site
267748000914	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
267748000915	active site
267748000916	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146
267748000917	dimer interface [polypeptide binding]; other site
267748000918	FMN binding site [chemical binding]; other site
267748000919	NADPH bind site [chemical binding]; other site
267748000920	Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200
267748000921	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
267748000922	Sulfatase; Region: Sulfatase; cl10460
267748000923	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
267748000924	active site
267748000925	substrate binding site [chemical binding]; other site
267748000926	The YihA (EngB) subfamily.  This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control.  YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876
267748000927	G1 box; other site
267748000928	GTP/Mg2+ binding site [chemical binding]; other site
267748000929	Switch I region; other site
267748000930	G2 box; other site
267748000931	G3 box; other site
267748000932	Switch II region; other site
267748000933	G4 box; other site
267748000934	G5 box; other site
267748000935	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
267748000936	DpnII restriction endonuclease; Region: DpnII; pfam04556
267748000937	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
267748000938	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
267748000939	non-specific DNA binding site [nucleotide binding]; other site
267748000940	salt bridge; other site
267748000941	sequence-specific DNA binding site [nucleotide binding]; other site
267748000942	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408
267748000943	Era subfamily.  Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria.  It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163
267748000944	GTPase Era; Reviewed; Region: era; PRK00089
267748000945	G1 box; other site
267748000946	GTP/Mg2+ binding site [chemical binding]; other site
267748000947	Switch I region; other site
267748000948	G2 box; other site
267748000949	Switch II region; other site
267748000950	G3 box; other site
267748000951	G4 box; other site
267748000952	G5 box; other site
267748000953	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098
267748000954	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
267748000955	active site
267748000956	catalytic motif [active]
267748000957	Zn binding site [ion binding]; other site
267748000958	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
267748000959	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
267748000960	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39E; cd02424
267748000961	putative active site [active]
267748000962	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
267748000963	Walker A/P-loop; other site
267748000964	ATP binding site [chemical binding]; other site
267748000965	Q-loop/lid; other site
267748000966	ABC transporter signature motif; other site
267748000967	Walker B; other site
267748000968	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
267748000969	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
267748000970	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
267748000971	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
267748000972	Walker A/P-loop; other site
267748000973	ATP binding site [chemical binding]; other site
267748000974	Q-loop/lid; other site
267748000975	ABC transporter signature motif; other site
267748000976	Walker B; other site
267748000977	D-loop; other site
267748000978	H-loop/switch region; other site
267748000979	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
267748000980	hypothetical protein; Provisional; Region: PRK13671
267748000981	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
267748000982	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
267748000983	comEA protein; Region: comE; TIGR01259
267748000984	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
267748000985	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
267748000986	trehalose synthase; Region: treS_nterm; TIGR02456
267748000987	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
267748000988	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
267748000989	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
267748000990	Walker A motif; other site
267748000991	ATP binding site [chemical binding]; other site
267748000992	Walker B motif; other site
267748000993	arginine finger; other site
267748000994	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
267748000995	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
267748000996	Walker A motif; other site
267748000997	ATP binding site [chemical binding]; other site
267748000998	Walker B motif; other site
267748000999	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
267748001000	elongation factor G; Reviewed; Region: PRK12739
267748001001	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
267748001002	G1 box; other site
267748001003	putative GEF interaction site [polypeptide binding]; other site
267748001004	GTP/Mg2+ binding site [chemical binding]; other site
267748001005	Switch I region; other site
267748001006	G2 box; other site
267748001007	G3 box; other site
267748001008	Switch II region; other site
267748001009	G4 box; other site
267748001010	G5 box; other site
267748001011	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
267748001012	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
267748001013	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
267748001014	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
267748001015	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
267748001016	S17 interaction site [polypeptide binding]; other site
267748001017	S8 interaction site; other site
267748001018	16S rRNA interaction site [nucleotide binding]; other site
267748001019	streptomycin interaction site [chemical binding]; other site
267748001020	23S rRNA interaction site [nucleotide binding]; other site
267748001021	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
267748001022	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
267748001023	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
267748001024	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
267748001025	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
267748001026	DNA binding site [nucleotide binding]
267748001027	catalytic residue [active]
267748001028	H2TH interface [polypeptide binding]; other site
267748001029	putative catalytic residues [active]
267748001030	turnover-facilitating residue; other site
267748001031	intercalation triad [nucleotide binding]; other site
267748001032	8OG recognition residue [nucleotide binding]; other site
267748001033	putative reading head residues; other site
267748001034	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
267748001035	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
267748001036	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
267748001037	active site
267748001038	catalytic triad [active]
267748001039	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
267748001040	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
267748001041	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
267748001042	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
267748001043	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
267748001044	GatB domain; Region: GatB_Yqey; cl11497
267748001045	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
267748001046	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
267748001047	cell division protein MraZ; Reviewed; Region: PRK00326
267748001048	MraZ protein; Region: MraZ; pfam02381
267748001049	MraZ protein; Region: MraZ; pfam02381
267748001050	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
267748001051	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
267748001052	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209
267748001053	DNA binding site [nucleotide binding]
267748001054	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
267748001055	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
267748001056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
267748001057	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
267748001058	anchoring element; other site
267748001059	dimer interface [polypeptide binding]; other site
267748001060	ATP binding site [chemical binding]; other site
267748001061	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
267748001062	active site
267748001063	metal binding site [ion binding]; metal-binding site
267748001064	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
267748001065	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
267748001066	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
267748001067	Walker A/P-loop; other site
267748001068	ATP binding site [chemical binding]; other site
267748001069	Q-loop/lid; other site
267748001070	ABC transporter signature motif; other site
267748001071	Walker B; other site
267748001072	D-loop; other site
267748001073	H-loop/switch region; other site
267748001074	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
267748001075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
267748001076	ABC-ATPase subunit interface; other site
267748001077	putative PBP binding loops; other site
267748001078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
267748001079	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
267748001080	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
267748001081	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
267748001082	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
267748001083	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
267748001084	beta-phosphoglucomutase; Region: bPGM; TIGR01990
267748001085	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
267748001086	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
267748001087	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
267748001088	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
267748001089	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
267748001090	ligand binding site [chemical binding]; other site
267748001091	oligomer interface [polypeptide binding]; other site
267748001092	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651
267748001093	dimer interface [polypeptide binding]; other site
267748001094	N-terminal domain interface [polypeptide binding]; other site
267748001095	sulfate 1 binding site; other site
267748001096	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
267748001097	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
267748001098	ligand binding site [chemical binding]; other site
267748001099	oligomer interface [polypeptide binding]; other site
267748001100	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651
267748001101	dimer interface [polypeptide binding]; other site
267748001102	N-terminal domain interface [polypeptide binding]; other site
267748001103	sulfate 1 binding site; other site
267748001104	pullulanase, type I; Region: pulA_typeI; TIGR02104
267748001105	Pullulanase domain N-terminus. Pullulanase (AKA dextrinase; alpha-dextrin endo-1,6-alpha glucosidase) is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-...; Region: Pullulanase_N_term; cd02860
267748001106	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
267748001107	glycogen branching enzyme; Provisional; Region: PRK12313
267748001108	Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855
267748001109	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
267748001110	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
267748001111	glycogen synthase; Provisional; Region: glgA; PRK00654
267748001112	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
267748001113	ADP-binding pocket [chemical binding]; other site
267748001114	homodimer interface [polypeptide binding]; other site
267748001115	GTP-binding protein LepA; Provisional; Region: PRK05433
267748001116	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
267748001117	G1 box; other site
267748001118	putative GEF interaction site [polypeptide binding]; other site
267748001119	GTP/Mg2+ binding site [chemical binding]; other site
267748001120	Switch I region; other site
267748001121	G2 box; other site
267748001122	G3 box; other site
267748001123	Switch II region; other site
267748001124	G4 box; other site
267748001125	G5 box; other site
267748001126	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699
267748001127	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
267748001128	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
267748001129	Smr domain; Region: Smr; cl02619
267748001130	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
267748001131	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
267748001132	putative active site [active]
267748001133	substrate binding site [chemical binding]; other site
267748001134	putative cosubstrate binding site; other site
267748001135	catalytic site [active]
267748001136	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
267748001137	substrate binding site [chemical binding]; other site
267748001138	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
267748001139	dimerization domain swap beta strand [polypeptide binding]; other site
267748001140	regulatory protein interface [polypeptide binding]; other site
267748001141	active site
267748001142	regulatory phosphorylation site [posttranslational modification]; other site
267748001143	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
267748001144	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
267748001145	active site
267748001146	HIGH motif; other site
267748001147	nucleotide binding site [chemical binding]; other site
267748001148	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
267748001149	active site
267748001150	KMSKS motif; other site
267748001151	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
267748001152	tRNA binding surface [nucleotide binding]; other site
267748001153	anticodon binding site; other site
267748001154	CTP synthetase; Validated; Region: pyrG; PRK05380
267748001155	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113
267748001156	Catalytic site [active]
267748001157	Active site [active]
267748001158	UTP binding site [chemical binding]; other site
267748001159	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
267748001160	active site
267748001161	putative oxyanion hole; other site
267748001162	catalytic triad [active]
267748001163	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
267748001164	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
267748001165	active site
267748001166	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
267748001167	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
267748001168	Walker A/P-loop; other site
267748001169	ATP binding site [chemical binding]; other site
267748001170	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
267748001171	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
267748001172	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
267748001173	Q-loop/lid; other site
267748001174	ABC transporter signature motif; other site
267748001175	Walker B; other site
267748001176	D-loop; other site
267748001177	H-loop/switch region; other site
267748001178	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
267748001179	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
267748001180	dimerization interface [polypeptide binding]; other site
267748001181	active site
267748001182	metal binding site [ion binding]; metal-binding site
267748001183	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048
267748001184	dsRNA binding site [nucleotide binding]; other site
267748001185	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
267748001186	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
267748001187	DAK2 domain; Region: Dak2; cl03685
267748001188	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
267748001189	Predicted membrane protein [Function unknown]; Region: COG3356
267748001190	hypothetical protein; Provisional; Region: PRK06148
267748001191	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
267748001192	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
267748001193	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
267748001194	substrate binding site [chemical binding]; other site
267748001195	dimer interface [polypeptide binding]; other site
267748001196	catalytic triad [active]
267748001197	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
267748001198	UDP-galactopyranose mutase; Region: UDP-GALP_mutase; TIGR00031
267748001199	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
267748001200	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
267748001201	active site
267748001202	GTPase CgtA; Reviewed; Region: obgE; PRK12297
267748001203	GTP1/OBG; Region: GTP1_OBG; pfam01018
267748001204	Obg subfamily.  The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation.  Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
267748001205	G1 box; other site
267748001206	GTP/Mg2+ binding site [chemical binding]; other site
267748001207	Switch I region; other site
267748001208	G2 box; other site
267748001209	G3 box; other site
267748001210	Switch II region; other site
267748001211	G4 box; other site
267748001212	G5 box; other site
267748001213	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
267748001214	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
267748001215	active site
267748001216	catalytic triad [active]
267748001217	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
267748001218	Cation transport protein; Region: TrkH; cl10514
267748001219	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
267748001220	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
267748001221	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
267748001222	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
267748001223	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
267748001224	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
267748001225	Cobalt transport protein; Region: CbiQ; cl00463
267748001226	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13651
267748001227	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
267748001228	Walker A/P-loop; other site
267748001229	ATP binding site [chemical binding]; other site
267748001230	Q-loop/lid; other site
267748001231	ABC transporter signature motif; other site
267748001232	Walker B; other site
267748001233	D-loop; other site
267748001234	H-loop/switch region; other site
267748001235	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632
267748001236	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
267748001237	Walker A/P-loop; other site
267748001238	ATP binding site [chemical binding]; other site
267748001239	Q-loop/lid; other site
267748001240	ABC transporter signature motif; other site
267748001241	Walker B; other site
267748001242	D-loop; other site
267748001243	H-loop/switch region; other site
267748001244	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
267748001245	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
267748001246	domain; Region: GreA_GreB_N; pfam03449
267748001247	C-term; Region: GreA_GreB; pfam01272
267748001248	Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525
267748001249	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
267748001250	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673
267748001251	motif 1; other site
267748001252	active site
267748001253	motif 2; other site
267748001254	motif 3; other site
267748001255	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
267748001256	DHHA1 domain; Region: DHHA1; pfam02272
267748001257	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
267748001258	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998
267748001259	Ligand Binding Site [chemical binding]; other site
267748001260	BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181
267748001261	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
267748001262	Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536
267748001263	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
267748001264	dimerization interface [polypeptide binding]; other site
267748001265	putative DNA binding site [nucleotide binding]; other site
267748001266	putative Zn2+ binding site [ion binding]; other site
267748001267	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
267748001268	Walker A/P-loop; other site
267748001269	ATP binding site [chemical binding]; other site
267748001270	Q-loop/lid; other site
267748001271	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
267748001272	ABC transporter signature motif; other site
267748001273	Walker B; other site
267748001274	D-loop; other site
267748001275	H-loop/switch region; other site
267748001276	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
267748001277	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198
267748001278	substrate binding site [chemical binding]; other site
267748001279	hinge regions; other site
267748001280	ADP binding site [chemical binding]; other site
267748001281	catalytic site [active]
267748001282	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
267748001283	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
267748001284	Walker A/P-loop; other site
267748001285	ATP binding site [chemical binding]; other site
267748001286	Q-loop/lid; other site
267748001287	ABC transporter signature motif; other site
267748001288	Walker B; other site
267748001289	D-loop; other site
267748001290	H-loop/switch region; other site
267748001291	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
267748001292	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
267748001293	dimer interface [polypeptide binding]; other site
267748001294	conserved gate region; other site
267748001295	ABC-ATPase subunit interface; other site
267748001296	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
267748001297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
267748001298	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
267748001299	substrate binding site [chemical binding]; other site
267748001300	hinge regions; other site
267748001301	ADP binding site [chemical binding]; other site
267748001302	catalytic site [active]
267748001303	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
267748001304	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
267748001305	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
267748001306	putative active site [active]
267748001307	catalytic site [active]
267748001308	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
267748001309	putative active site [active]
267748001310	catalytic site [active]
267748001311	Chromate transporter; Region: Chromate_transp; pfam02417
267748001312	Chromate transporter; Region: Chromate_transp; pfam02417
267748001313	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
267748001314	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
267748001315	CAP-like domain; other site
267748001316	Active site [active]
267748001317	primary dimer interface [polypeptide binding]; other site
267748001318	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
267748001319	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
267748001320	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
267748001321	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433
267748001322	interface (dimer of trimers) [polypeptide binding]; other site
267748001323	Substrate-binding/catalytic site; other site
267748001324	Zn-binding sites [ion binding]; other site
267748001325	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
267748001326	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212
267748001327	active site turn [active]
267748001328	phosphorylation site [posttranslational modification]
267748001329	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
267748001330	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
267748001331	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
267748001332	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
267748001333	active site
267748001334	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
267748001335	putative substrate binding site [chemical binding]; other site
267748001336	putative ATP binding site [chemical binding]; other site
267748001337	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02193
267748001338	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573
267748001339	RNA binding site [nucleotide binding]; other site
267748001340	active site
267748001341	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
267748001342	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
267748001343	active site
267748001344	motif I; other site
267748001345	motif II; other site
267748001346	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
267748001347	hypothetical protein; Provisional; Region: PRK07143
267748001348	Cytidylyltransferase-like domain; Region: cytidylyltransferase_like; cd02039
267748001349	active site
267748001350	(T/H)XGH motif; other site
267748001351	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353
267748001352	16S/18S rRNA binding site [nucleotide binding]; other site
267748001353	S13e-L30e interaction site [polypeptide binding]; other site
267748001354	25S rRNA binding site [nucleotide binding]; other site
267748001355	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378
267748001356	dimer interface [polypeptide binding]; other site
267748001357	glycine-pyridoxal phosphate binding site [chemical binding]; other site
267748001358	active site
267748001359	folate binding site [chemical binding]; other site
267748001360	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236
267748001361	dimerization interface [polypeptide binding]; other site
267748001362	domain crossover interface; other site
267748001363	redox-dependent activation switch; other site
267748001364	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
267748001365	active site
267748001366	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
267748001367	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
267748001368	active site
267748001369	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
267748001370	ScpA/B protein; Region: ScpA_ScpB; cl00598
267748001371	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
267748001372	putative acyl-acceptor binding pocket; other site
267748001373	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
267748001374	Recombination protein U; Region: RecU; cl01314
267748001375	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
267748001376	IHF - DNA interface [nucleotide binding]; other site
267748001377	IHF dimer interface [polypeptide binding]; other site
267748001378	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
267748001379	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
267748001380	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
267748001381	ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594
267748001382	EngA1 subfamily.  This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894
267748001383	G1 box; other site
267748001384	GTP/Mg2+ binding site [chemical binding]; other site
267748001385	Switch I region; other site
267748001386	G2 box; other site
267748001387	Switch II region; other site
267748001388	G3 box; other site
267748001389	G4 box; other site
267748001390	G5 box; other site
267748001391	EngA2 subfamily.  This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895
267748001392	G1 box; other site
267748001393	GTP/Mg2+ binding site [chemical binding]; other site
267748001394	Switch I region; other site
267748001395	G2 box; other site
267748001396	G3 box; other site
267748001397	Switch II region; other site
267748001398	G4 box; other site
267748001399	G5 box; other site
267748001400	cytidylate kinase; Provisional; Region: cmk; PRK00023
267748001401	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
267748001402	CMP-binding site; other site
267748001403	The sites determining sugar specificity; other site
267748001404	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
267748001405	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
267748001406	HSP70 interaction site [polypeptide binding]; other site
267748001407	DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908
267748001408	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
267748001409	DNA polymerase III DnaE; Validated; Region: dnaE; PRK07135
267748001410	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
267748001411	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
267748001412	5'-3' exonuclease; Provisional; Region: PRK14976
267748001413	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
267748001414	active site
267748001415	metal binding site 1 [ion binding]; metal-binding site
267748001416	putative 5' ssDNA interaction site; other site
267748001417	metal binding site 3; metal-binding site
267748001418	metal binding site 2 [ion binding]; metal-binding site
267748001419	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
267748001420	putative DNA binding site [nucleotide binding]; other site
267748001421	putative metal binding site [ion binding]; other site
267748001422	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
267748001423	UvrD/REP helicase; Region: UvrD-helicase; cl14126
267748001424	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
267748001425	UvrD/REP helicase; Region: UvrD-helicase; cl14126
267748001426	RDD family; Region: RDD; cl00746
267748001427	DNA gyrase subunit A; Validated; Region: PRK05560
267748001428	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
267748001429	CAP-like domain; other site
267748001430	Active site [active]
267748001431	primary dimer interface [polypeptide binding]; other site
267748001432	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
267748001433	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
267748001434	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
267748001435	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
267748001436	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
267748001437	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
267748001438	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
267748001439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
267748001440	S-adenosylmethionine binding site [chemical binding]; other site
267748001441	Protein of unknown function (DUF402); Region: DUF402; cl00979
267748001442	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
267748001443	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cl00164
267748001444	active site turn [active]
267748001445	phosphorylation site [posttranslational modification]
267748001446	tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233
267748001447	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
267748001448	active site
267748001449	HIGH motif; other site
267748001450	dimer interface [polypeptide binding]; other site
267748001451	KMSKS motif; other site
267748001452	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
267748001453	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
267748001454	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
267748001455	S-adenosylmethionine binding site [chemical binding]; other site
267748001456	Catalytic domain of Protein Kinases; Region: PKc; cd00180
267748001457	active site
267748001458	ATP binding site [chemical binding]; other site
267748001459	substrate binding site [chemical binding]; other site
267748001460	activation loop (A-loop); other site
267748001461	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
267748001462	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318
267748001463	putative dimer interface [polypeptide binding]; other site
267748001464	putative anticodon binding site; other site
267748001465	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
267748001466	motif 1; other site
267748001467	dimer interface [polypeptide binding]; other site
267748001468	active site
267748001469	motif 2; other site
267748001470	motif 3; other site
267748001471	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
267748001472	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
267748001473	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254
267748001474	Walker A/P-loop; other site
267748001475	ATP binding site [chemical binding]; other site
267748001476	Q-loop/lid; other site
267748001477	ABC transporter signature motif; other site
267748001478	Walker B; other site
267748001479	D-loop; other site
267748001480	H-loop/switch region; other site
267748001481	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
267748001482	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
267748001483	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
267748001484	Walker A/P-loop; other site
267748001485	ATP binding site [chemical binding]; other site
267748001486	Q-loop/lid; other site
267748001487	ABC transporter signature motif; other site
267748001488	Walker B; other site
267748001489	D-loop; other site
267748001490	H-loop/switch region; other site
267748001491	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
267748001492	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
267748001493	putative active site [active]
267748001494	metal binding site [ion binding]; metal-binding site
267748001495	homodimer binding site [polypeptide binding]; other site
267748001496	recombinase A; Provisional; Region: recA; PRK09354
267748001497	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
267748001498	hexamer interface [polypeptide binding]; other site
267748001499	Walker A motif; other site
267748001500	ATP binding site [chemical binding]; other site
267748001501	Walker B motif; other site
267748001502	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
267748001503	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
267748001504	putative tRNA-binding site [nucleotide binding]; other site
267748001505	B3/4 domain; Region: B3_4; cl11458
267748001506	tRNA synthetase B5 domain; Region: B5; cl08394
267748001507	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
267748001508	motif 1; other site
267748001509	dimer interface [polypeptide binding]; other site
267748001510	active site
267748001511	motif 3; other site
267748001512	recombination factor protein RarA; Reviewed; Region: PRK13342
267748001513	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
267748001514	Walker A motif; other site
267748001515	ATP binding site [chemical binding]; other site
267748001516	Walker B motif; other site
267748001517	arginine finger; other site
267748001518	MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440
267748001519	Protein of unknown function DUF45; Region: DUF45; cl00636
267748001520	Nuclease-related domain; Region: NERD; pfam08378
267748001521	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
267748001522	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
267748001523	dimer interface [polypeptide binding]; other site
267748001524	substrate binding site [chemical binding]; other site
267748001525	metal binding sites [ion binding]; metal-binding site
267748001526	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
267748001527	active site
267748001528	catalytic triad [active]
267748001529	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
267748001530	dimer interface [polypeptide binding]; other site
267748001531	catalytic triad [active]
267748001532	peroxidatic and resolving cysteines [active]
267748001533	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2)...; Region: phosphohexomutase; cl03757
267748001534	metal binding site [ion binding]; metal-binding site
267748001535	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
267748001536	DNA polymerase III subunit delta'; Validated; Region: PRK07132
267748001537	signal recognition particle protein; Provisional; Region: PRK10867
267748001538	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
267748001539	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
267748001540	P loop; other site
267748001541	GTP binding site [chemical binding]; other site
267748001542	Signal peptide binding domain; Region: SRP_SPB; pfam02978
267748001543	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
267748001544	mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659
267748001545	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
267748001546	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
267748001547	catalytic motif [active]
267748001548	Zn binding site [ion binding]; other site
267748001549	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
267748001550	putative tRNA-binding site [nucleotide binding]; other site
267748001551	Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577
267748001552	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797
267748001553	23S rRNA interface [nucleotide binding]; other site
267748001554	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
267748001555	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
267748001556	core dimer interface [polypeptide binding]; other site
267748001557	peripheral dimer interface [polypeptide binding]; other site
267748001558	L10 interface [polypeptide binding]; other site
267748001559	L11 interface [polypeptide binding]; other site
267748001560	putative EF-Tu interaction site [polypeptide binding]; other site
267748001561	putative EF-G interaction site [polypeptide binding]; other site
267748001562	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
267748001563	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
267748001564	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
267748001565	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
267748001566	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
267748001567	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
267748001568	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
267748001569	intersubunit interface [polypeptide binding]; other site
267748001570	active site
267748001571	catalytic residue [active]
267748001572	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
267748001573	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
267748001574	active site
267748001575	HIGH motif; other site
267748001576	KMSKS motif; other site
267748001577	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
267748001578	tRNA binding surface [nucleotide binding]; other site
267748001579	anticodon binding site; other site
267748001580	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
267748001581	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
267748001582	Walker B motif; other site
267748001583	arginine finger; other site
267748001584	Peptidase family M41; Region: Peptidase_M41; pfam01434
267748001585	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
267748001586	putative active site [active]
267748001587	catalytic residue [active]
267748001588	Ferritin-like domain; Region: Ferritin; pfam00210
267748001589	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
267748001590	dimerization interface [polypeptide binding]; other site
267748001591	DPS ferroxidase diiron center [ion binding]; other site
267748001592	ion pore; other site
267748001593	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
267748001594	GIY-YIG catalytic domain; Region: GIY-YIG; cl01061
267748001595	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
267748001596	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
267748001597	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
267748001598	active site
267748001599	HIGH motif; other site
267748001600	dimer interface [polypeptide binding]; other site
267748001601	KMSKS motif; other site
267748001602	endonuclease IV; Provisional; Region: PRK01060
267748001603	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019
267748001604	AP (apurinic/apyrimidinic) site pocket; other site
267748001605	DNA interaction; other site
267748001606	Metal-binding active site; metal-binding site
267748001607	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
267748001608	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
267748001609	aminopeptidase; Provisional; Region: PRK09795
267748001610	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
267748001611	active site
267748001612	elongation factor P; Validated; Region: PRK00529
267748001613	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
267748001614	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470
267748001615	RNA binding site [nucleotide binding]; other site
267748001616	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794
267748001617	RNA binding site [nucleotide binding]; other site
267748001618	transketolase; Reviewed; Region: PRK05899
267748001619	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
267748001620	TPP-binding site [chemical binding]; other site
267748001621	dimer interface [polypeptide binding]; other site
267748001622	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
267748001623	PYR/PP interface [polypeptide binding]; other site
267748001624	dimer interface [polypeptide binding]; other site
267748001625	TPP binding site [chemical binding]; other site
267748001626	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
267748001627	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
267748001628	active site
267748001629	dimer interface [polypeptide binding]; other site
267748001630	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
267748001631	dimer interface [polypeptide binding]; other site
267748001632	active site
267748001633	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
267748001634	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
267748001635	S-adenosylmethionine binding site [chemical binding]; other site
267748001636	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071
267748001637	catalytic site [active]
267748001638	G-X2-G-X-G-K; other site
267748001639	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
267748001640	Protein phosphatase 2C; Region: PP2C; pfam00481
267748001641	Active site [active]
267748001642	Catalytic domain of Protein Kinases; Region: PKc; cd00180
267748001643	active site
267748001644	ATP binding site [chemical binding]; other site
267748001645	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
267748001646	substrate binding site [chemical binding]; other site
267748001647	activation loop (A-loop); other site
267748001648	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
267748001649	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
267748001650	GTPase/Zn-binding domain interface [polypeptide binding]; other site
267748001651	GTP/Mg2+ binding site [chemical binding]; other site
267748001652	G4 box; other site
267748001653	G5 box; other site
267748001654	G1 box; other site
267748001655	Switch I region; other site
267748001656	G2 box; other site
267748001657	G3 box; other site
267748001658	Switch II region; other site
267748001659	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
267748001660	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
267748001661	substrate binding site [chemical binding]; other site
267748001662	hexamer interface [polypeptide binding]; other site
267748001663	metal binding site [ion binding]; metal-binding site
267748001664	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
267748001665	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
267748001666	TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes.  It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes.  TrmE contains a GTPase...; Region: trmE; cd04164
267748001667	G1 box; other site
267748001668	GTP/Mg2+ binding site [chemical binding]; other site
267748001669	Switch I region; other site
267748001670	G2 box; other site
267748001671	Switch II region; other site
267748001672	G3 box; other site
267748001673	G4 box; other site
267748001674	G5 box; other site
267748001675	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
267748001676	putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
267748001677	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
267748001678	active site
267748001679	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
267748001680	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
267748001681	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
267748001682	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
267748001683	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
267748001684	S-adenosylmethionine binding site [chemical binding]; other site
267748001685	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
267748001686	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
267748001687	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
267748001688	active site
267748001689	dimer interface [polypeptide binding]; other site
267748001690	motif 1; other site
267748001691	motif 2; other site
267748001692	motif 3; other site
267748001693	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
267748001694	anticodon binding site; other site
267748001695	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
267748001696	catalytic residues [active]
267748001697	excinuclease ABC subunit B; Provisional; Region: PRK05298
267748001698	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
267748001699	ATP binding site [chemical binding]; other site
267748001700	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
267748001701	nucleotide binding region [chemical binding]; other site
267748001702	ATP-binding site [chemical binding]; other site
267748001703	Ultra-violet resistance protein B; Region: UvrB; pfam12344
267748001704	UvrB/uvrC motif; Region: UVR; pfam02151
267748001705	LemA family; Region: LemA; cl00742
267748001706	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
267748001707	active site
267748001708	HIGH motif; other site
267748001709	nucleotide binding site [chemical binding]; other site
267748001710	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
267748001711	CoA-binding site [chemical binding]; other site
267748001712	ATP-binding [chemical binding]; other site
267748001713	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
267748001714	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454
267748001715	substrate-cofactor binding pocket; other site
267748001716	pyridoxal 5'-phosphate binding site [chemical binding]; other site
267748001717	catalytic residue [active]
267748001718	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
267748001719	L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272
267748001720	NAD binding site [chemical binding]; other site
267748001721	homodimer interface [polypeptide binding]; other site
267748001722	active site
267748001723	putative substrate binding site [chemical binding]; other site
267748001724	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
267748001725	E3 interaction surface; other site
267748001726	lipoyl attachment site [posttranslational modification]; other site
267748001727	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
267748001728	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
267748001729	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
267748001730	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
267748001731	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
267748001732	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
267748001733	E3 interaction surface; other site
267748001734	lipoyl attachment site [posttranslational modification]; other site
267748001735	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
267748001736	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
267748001737	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
267748001738	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
267748001739	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
267748001740	alpha subunit interface [polypeptide binding]; other site
267748001741	TPP binding site [chemical binding]; other site
267748001742	heterodimer interface [polypeptide binding]; other site
267748001743	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
267748001744	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
267748001745	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
267748001746	tetramer interface [polypeptide binding]; other site
267748001747	TPP-binding site [chemical binding]; other site
267748001748	heterodimer interface [polypeptide binding]; other site
267748001749	phosphorylation loop region [posttranslational modification]
267748001750	Protein of unknown function (DUF328); Region: DUF328; cl01143
267748001751	PQ loop repeat; Region: PQ-loop; cl12056
267748001752	PQ loop repeat; Region: PQ-loop; cl12056
267748001753	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
267748001754	conserved cys residue [active]
267748001755	Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130
267748001756	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
267748001757	Flavoprotein; Region: Flavoprotein; cl08021
267748001758	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
267748001759	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
267748001760	dimer interface [polypeptide binding]; other site
267748001761	active site
267748001762	ATP binding site [chemical binding]; other site
267748001763	substrate binding site [chemical binding]; other site
267748001764	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
267748001765	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
267748001766	dimerization interface [polypeptide binding]; other site
267748001767	active site
267748001768	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
267748001769	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
267748001770	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
267748001771	GTP-binding protein YchF; Reviewed; Region: PRK09601
267748001772	YchF subfamily.  YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1.  Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
267748001773	G1 box; other site
267748001774	GTP/Mg2+ binding site [chemical binding]; other site
267748001775	Switch I region; other site
267748001776	G2 box; other site
267748001777	Switch II region; other site
267748001778	G3 box; other site
267748001779	G4 box; other site
267748001780	G5 box; other site
267748001781	GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information on the function of the TGS domain, but...; Region: TGS; cl03735
267748001782	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
267748001783	substrate binding site [chemical binding]; other site
267748001784	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
267748001785	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
267748001786	active site
267748001787	phosphorylation site [posttranslational modification]
267748001788	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569
267748001789	P-loop; other site
267748001790	active site
267748001791	phosphorylation site [posttranslational modification]
267748001792	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
267748001793	Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200
267748001794	Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200
267748001795	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
267748001796	Protein of unknown function DUF262; Region: DUF262; cl14890
267748001797	Protein of unknown function DUF262; Region: DUF262; cl14890
267748001798	Signal recognition particle GTPase [Intracellular trafficking and secretion]; Region: FtsY; COG0552
267748001799	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
267748001800	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
267748001801	Walker A motif; other site
267748001802	ATP binding site [chemical binding]; other site
267748001803	Walker B motif; other site
267748001804	Uncharacterized conserved protein [Function unknown]; Region: COG3410
267748001805	Thymidine kinase; Region: TK; cl00631
267748001806	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
267748001807	active site
267748001808	catalytic residues [active]
267748001809	metal binding site [ion binding]; metal-binding site
267748001810	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
267748001811	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
267748001812	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
267748001813	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
267748001814	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
267748001815	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
267748001816	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
267748001817	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
267748001818	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
267748001819	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
267748001820	Walker A/P-loop; other site
267748001821	ATP binding site [chemical binding]; other site
267748001822	Q-loop/lid; other site
267748001823	ABC transporter signature motif; other site
267748001824	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
267748001825	Walker B; other site
267748001826	D-loop; other site
267748001827	H-loop/switch region; other site
267748001828	ABC transporter; Region: ABC_tran_2; pfam12848
267748001829	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
267748001830	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
267748001831	RNA/DNA hybrid binding site [nucleotide binding]; other site
267748001832	active site
267748001833	PQ loop repeat; Region: PQ-loop; cl12056
267748001834	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
267748001835	23S rRNA binding site [nucleotide binding]; other site
267748001836	L21 binding site [polypeptide binding]; other site
267748001837	L13 binding site [polypeptide binding]; other site
267748001838	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
267748001839	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
267748001840	translation initiation factor IF-3; Region: infC; TIGR00168
267748001841	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
267748001842	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
267748001843	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
267748001844	Ribonuclease P; Region: Ribonuclease_P; cl00457
267748001845	Ribosomal protein L34; Region: Ribosomal_L34; cl00370