-- dump date 20120504_153434 -- class Genbank::misc_feature -- table misc_feature_note -- id note 862259000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14087 862259000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862259000003 Walker A motif; other site 862259000004 ATP binding site [chemical binding]; other site 862259000005 Walker B motif; other site 862259000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 862259000007 DnaA box-binding interface [nucleotide binding]; other site 862259000008 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 862259000009 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 862259000010 putative DNA binding surface [nucleotide binding]; other site 862259000011 dimer interface [polypeptide binding]; other site 862259000012 beta-clamp/clamp loader binding surface; other site 862259000013 beta-clamp/translesion DNA polymerase binding surface; other site 862259000014 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 862259000015 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 862259000016 putative active site [active] 862259000017 putative metal binding site [ion binding]; other site 862259000018 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 862259000019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862259000020 S-adenosylmethionine binding site [chemical binding]; other site 862259000021 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 862259000022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862259000023 ATP binding site [chemical binding]; other site 862259000024 Mg2+ binding site [ion binding]; other site 862259000025 G-X-G motif; other site 862259000026 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 862259000027 anchoring element; other site 862259000028 dimer interface [polypeptide binding]; other site 862259000029 ATP binding site [chemical binding]; other site 862259000030 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 862259000031 active site 862259000032 putative metal-binding site [ion binding]; other site 862259000033 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 862259000034 DNA gyrase subunit A; Validated; Region: PRK05560 862259000035 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 862259000036 CAP-like domain; other site 862259000037 active site 862259000038 primary dimer interface [polypeptide binding]; other site 862259000039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862259000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862259000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862259000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862259000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862259000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862259000045 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862259000046 TM-ABC transporter signature motif; other site 862259000047 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862259000048 TM-ABC transporter signature motif; other site 862259000049 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 862259000050 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 862259000051 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 862259000052 Walker A/P-loop; other site 862259000053 ATP binding site [chemical binding]; other site 862259000054 Q-loop/lid; other site 862259000055 ABC transporter signature motif; other site 862259000056 Walker B; other site 862259000057 D-loop; other site 862259000058 H-loop/switch region; other site 862259000059 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 862259000060 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862259000061 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862259000062 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 862259000063 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 862259000064 active site 862259000065 HIGH motif; other site 862259000066 KMSKS motif; other site 862259000067 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 862259000068 tRNA binding surface [nucleotide binding]; other site 862259000069 anticodon binding site; other site 862259000070 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 862259000071 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 862259000072 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 862259000073 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 862259000074 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 862259000075 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 862259000076 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 862259000077 putative active site [active] 862259000078 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 862259000079 active site 862259000080 phosphorylation site [posttranslational modification] 862259000081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259000082 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 862259000083 NAD(P) binding site [chemical binding]; other site 862259000084 active site 862259000085 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 862259000086 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259000087 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 862259000088 active site 862259000089 P-loop; other site 862259000090 phosphorylation site [posttranslational modification] 862259000091 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 862259000092 Divergent AAA domain; Region: AAA_4; pfam04326 862259000093 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 862259000094 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 862259000095 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 862259000096 dimer interface [polypeptide binding]; other site 862259000097 ssDNA binding site [nucleotide binding]; other site 862259000098 tetramer (dimer of dimers) interface [polypeptide binding]; other site 862259000099 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 862259000100 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 862259000101 DNA-binding site [nucleotide binding]; DNA binding site 862259000102 RNA-binding motif; other site 862259000103 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 862259000104 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 862259000105 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 862259000106 Walker A/P-loop; other site 862259000107 ATP binding site [chemical binding]; other site 862259000108 Q-loop/lid; other site 862259000109 ABC transporter signature motif; other site 862259000110 Walker B; other site 862259000111 D-loop; other site 862259000112 H-loop/switch region; other site 862259000113 Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones]; Region: COG1281 862259000114 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 862259000115 dimerization interface [polypeptide binding]; other site 862259000116 domain crossover interface; other site 862259000117 redox-dependent activation switch; other site 862259000118 GnsA/GnsB family; Region: GnsAB; pfam08178 862259000119 FtsX-like permease family; Region: FtsX; cl15850 862259000120 FtsX-like permease family; Region: FtsX; cl15850 862259000121 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259000122 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 862259000123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259000124 Membrane transport protein; Region: Mem_trans; cl09117 862259000125 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000126 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 862259000127 FtsH Extracellular; Region: FtsH_ext; pfam06480 862259000128 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 862259000129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862259000130 Walker A motif; other site 862259000131 ATP binding site [chemical binding]; other site 862259000132 Walker B motif; other site 862259000133 arginine finger; other site 862259000134 Peptidase family M41; Region: Peptidase_M41; pfam01434 862259000135 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 862259000136 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 862259000137 Ligand Binding Site [chemical binding]; other site 862259000138 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 862259000139 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 862259000140 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 862259000141 putative active site [active] 862259000142 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 862259000143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862259000144 S-adenosylmethionine binding site [chemical binding]; other site 862259000145 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 862259000146 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000147 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 862259000148 thymidylate kinase; Validated; Region: tmk; PRK00698 862259000149 TMP-binding site; other site 862259000150 ATP-binding site [chemical binding]; other site 862259000151 recombination protein RecR; Reviewed; Region: recR; PRK00076 862259000152 RecR protein; Region: RecR; pfam02132 862259000153 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 862259000154 putative active site [active] 862259000155 putative metal-binding site [ion binding]; other site 862259000156 tetramer interface [polypeptide binding]; other site 862259000157 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 862259000158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862259000159 Walker A motif; other site 862259000160 ATP binding site [chemical binding]; other site 862259000161 Walker B motif; other site 862259000162 arginine finger; other site 862259000163 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 862259000164 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 862259000165 nucleoside/Zn binding site; other site 862259000166 dimer interface [polypeptide binding]; other site 862259000167 catalytic motif [active] 862259000168 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 862259000169 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 862259000170 active site 862259000171 Putative peptidase (DUF31); Region: DUF31; pfam01732 862259000172 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 862259000173 catalytic triad [active] 862259000174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259000175 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 862259000176 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 862259000177 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 862259000178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259000179 Predicted membrane protein [Function unknown]; Region: COG2364 862259000180 seryl-tRNA synthetase; Provisional; Region: PRK05431 862259000181 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 862259000182 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 862259000183 dimer interface [polypeptide binding]; other site 862259000184 active site 862259000185 motif 1; other site 862259000186 motif 2; other site 862259000187 motif 3; other site 862259000188 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 862259000189 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 862259000190 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 862259000191 FMN binding site [chemical binding]; other site 862259000192 active site 862259000193 catalytic residues [active] 862259000194 substrate binding site [chemical binding]; other site 862259000195 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 862259000196 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 862259000197 dimer interface [polypeptide binding]; other site 862259000198 putative anticodon binding site; other site 862259000199 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 862259000200 motif 1; other site 862259000201 active site 862259000202 motif 2; other site 862259000203 motif 3; other site 862259000204 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 862259000205 catalytic residues [active] 862259000206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862259000207 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 862259000208 active site 862259000209 motif I; other site 862259000210 motif II; other site 862259000211 Competence protein; Region: Competence; cl00471 862259000212 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862259000213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862259000214 dimer interface [polypeptide binding]; other site 862259000215 conserved gate region; other site 862259000216 putative PBP binding loops; other site 862259000217 ABC-ATPase subunit interface; other site 862259000218 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862259000219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862259000220 dimer interface [polypeptide binding]; other site 862259000221 conserved gate region; other site 862259000222 putative PBP binding loops; other site 862259000223 ABC-ATPase subunit interface; other site 862259000224 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 862259000225 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 862259000226 Walker A/P-loop; other site 862259000227 ATP binding site [chemical binding]; other site 862259000228 Q-loop/lid; other site 862259000229 ABC transporter signature motif; other site 862259000230 Walker B; other site 862259000231 D-loop; other site 862259000232 H-loop/switch region; other site 862259000233 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 862259000234 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 862259000235 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 862259000236 putative dimer interface [polypeptide binding]; other site 862259000237 putative anticodon binding site; other site 862259000238 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 862259000239 homodimer interface [polypeptide binding]; other site 862259000240 motif 1; other site 862259000241 motif 2; other site 862259000242 active site 862259000243 motif 3; other site 862259000244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862259000245 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 862259000246 active site 862259000247 motif I; other site 862259000248 motif II; other site 862259000249 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862259000250 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 862259000251 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 862259000252 UGMP family protein; Validated; Region: PRK09604 862259000253 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 862259000254 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 862259000255 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 862259000256 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 862259000257 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 862259000258 trmE is a tRNA modification GTPase; Region: trmE; cd04164 862259000259 G1 box; other site 862259000260 GTP/Mg2+ binding site [chemical binding]; other site 862259000261 Switch I region; other site 862259000262 G2 box; other site 862259000263 Switch II region; other site 862259000264 G3 box; other site 862259000265 G4 box; other site 862259000266 G5 box; other site 862259000267 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 862259000268 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 862259000269 HTH-like domain; Region: HTH_21; pfam13276 862259000270 Integrase core domain; Region: rve; cl01316 862259000271 Integrase core domain; Region: rve_3; cl15866 862259000272 Helix-turn-helix domains; Region: HTH; cl00088 862259000273 Helix-turn-helix domains; Region: HTH; cl00088 862259000274 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 862259000275 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 862259000276 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 862259000277 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259000278 TMPIT-like protein; Region: TMPIT; pfam07851 862259000279 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 862259000280 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 862259000281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862259000282 nucleotide binding region [chemical binding]; other site 862259000283 ATP-binding site [chemical binding]; other site 862259000284 Uncharacterized conserved protein [Function unknown]; Region: COG1739 862259000285 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 862259000286 5'-3' exonuclease; Region: 53EXOc; smart00475 862259000287 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 862259000288 active site 862259000289 metal binding site 1 [ion binding]; metal-binding site 862259000290 putative 5' ssDNA interaction site; other site 862259000291 metal binding site 3; metal-binding site 862259000292 metal binding site 2 [ion binding]; metal-binding site 862259000293 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 862259000294 putative DNA binding site [nucleotide binding]; other site 862259000295 putative metal binding site [ion binding]; other site 862259000296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259000297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259000298 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 862259000299 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 862259000300 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000301 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 862259000302 CoA-binding site [chemical binding]; other site 862259000303 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 862259000304 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862259000305 RNA binding surface [nucleotide binding]; other site 862259000306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 862259000307 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 862259000308 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 862259000309 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 862259000310 generic binding surface II; other site 862259000311 generic binding surface I; other site 862259000312 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 862259000313 putative RNA binding site [nucleotide binding]; other site 862259000314 endonuclease IV; Provisional; Region: PRK01060 862259000315 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 862259000316 AP (apurinic/apyrimidinic) site pocket; other site 862259000317 DNA interaction; other site 862259000318 Metal-binding active site; metal-binding site 862259000319 Riboflavin kinase; Region: Flavokinase; cl03312 862259000320 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 862259000321 Active site serine [active] 862259000322 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862259000323 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 862259000324 DXD motif; other site 862259000325 putative transposase OrfB; Reviewed; Region: PHA02517 862259000326 HTH-like domain; Region: HTH_21; pfam13276 862259000327 Integrase core domain; Region: rve; cl01316 862259000328 Integrase core domain; Region: rve_3; cl15866 862259000329 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862259000330 active site 862259000331 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 862259000332 active site 862259000333 tetramer interface; other site 862259000334 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 862259000335 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 862259000336 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 862259000337 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 862259000338 ABC transporter; Region: ABC_tran_2; pfam12848 862259000339 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 862259000340 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 862259000341 active site 862259000342 threonine dehydratase; Provisional; Region: PRK08198 862259000343 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 862259000344 tetramer interface [polypeptide binding]; other site 862259000345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862259000346 catalytic residue [active] 862259000347 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862259000348 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 862259000349 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259000350 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 862259000351 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 862259000352 active site turn [active] 862259000353 phosphorylation site [posttranslational modification] 862259000354 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 862259000355 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 862259000356 HIGH motif; other site 862259000357 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 862259000358 active site 862259000359 KMSKS motif; other site 862259000360 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 862259000361 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862259000362 Zn2+ binding site [ion binding]; other site 862259000363 Mg2+ binding site [ion binding]; other site 862259000364 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 862259000365 CTP synthetase; Validated; Region: pyrG; PRK05380 862259000366 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 862259000367 Catalytic site [active] 862259000368 active site 862259000369 UTP binding site [chemical binding]; other site 862259000370 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 862259000371 active site 862259000372 putative oxyanion hole; other site 862259000373 catalytic triad [active] 862259000374 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259000375 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259000376 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 862259000377 hypothetical protein; Provisional; Region: PRK08185 862259000378 intersubunit interface [polypeptide binding]; other site 862259000379 active site 862259000380 zinc binding site [ion binding]; other site 862259000381 Na+ binding site [ion binding]; other site 862259000382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862259000383 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862259000384 Walker A motif; other site 862259000385 ATP binding site [chemical binding]; other site 862259000386 Walker B motif; other site 862259000387 arginine finger; other site 862259000388 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 862259000389 active site 862259000390 catalytic triad [active] 862259000391 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862259000392 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 862259000393 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 862259000394 active site 862259000395 catalytic site [active] 862259000396 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 862259000397 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 862259000398 DHH family; Region: DHH; pfam01368 862259000399 DHHA1 domain; Region: DHHA1; pfam02272 862259000400 thymidine kinase; Provisional; Region: PRK04296 862259000401 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000402 Switch II region; other site 862259000403 G3 box; other site 862259000404 peptide chain release factor 1; Validated; Region: prfA; PRK00591 862259000405 Sec1 family; Region: Sec1; cl15415 862259000406 RF-1 domain; Region: RF-1; cl02875 862259000407 RF-1 domain; Region: RF-1; cl02875 862259000408 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 862259000409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259000410 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 862259000411 cardiolipin synthetase; Reviewed; Region: PRK12452 862259000412 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 862259000413 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 862259000414 putative active site [active] 862259000415 catalytic site [active] 862259000416 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 862259000417 putative active site [active] 862259000418 catalytic site [active] 862259000419 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 862259000420 S17 interaction site [polypeptide binding]; other site 862259000421 S8 interaction site; other site 862259000422 16S rRNA interaction site [nucleotide binding]; other site 862259000423 streptomycin interaction site [chemical binding]; other site 862259000424 23S rRNA interaction site [nucleotide binding]; other site 862259000425 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 862259000426 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 862259000427 elongation factor G; Reviewed; Region: PRK00007 862259000428 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 862259000429 G1 box; other site 862259000430 putative GEF interaction site [polypeptide binding]; other site 862259000431 GTP/Mg2+ binding site [chemical binding]; other site 862259000432 Switch I region; other site 862259000433 G2 box; other site 862259000434 G3 box; other site 862259000435 Switch II region; other site 862259000436 G4 box; other site 862259000437 G5 box; other site 862259000438 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 862259000439 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 862259000440 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 862259000441 elongation factor Tu; Reviewed; Region: PRK00049 862259000442 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 862259000443 G1 box; other site 862259000444 GEF interaction site [polypeptide binding]; other site 862259000445 GTP/Mg2+ binding site [chemical binding]; other site 862259000446 Switch I region; other site 862259000447 G2 box; other site 862259000448 G3 box; other site 862259000449 Switch II region; other site 862259000450 G4 box; other site 862259000451 G5 box; other site 862259000452 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 862259000453 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 862259000454 Antibiotic Binding Site [chemical binding]; other site 862259000455 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 862259000456 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259000457 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259000458 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 862259000459 active site turn [active] 862259000460 phosphorylation site [posttranslational modification] 862259000461 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 862259000462 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 862259000463 active site 862259000464 homotrimer interface [polypeptide binding]; other site 862259000465 catalytic site [active] 862259000466 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 862259000467 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 862259000468 interface (dimer of trimers) [polypeptide binding]; other site 862259000469 Substrate-binding/catalytic site; other site 862259000470 Zn-binding sites [ion binding]; other site 862259000471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862259000472 S-adenosylmethionine binding site [chemical binding]; other site 862259000473 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 862259000474 MgtE intracellular N domain; Region: MgtE_N; cl15244 862259000475 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 862259000476 Divalent cation transporter; Region: MgtE; cl00786 862259000477 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 862259000478 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 862259000479 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259000480 Integrase core domain; Region: rve; cl01316 862259000481 Integrase core domain; Region: rve_3; cl15866 862259000482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 862259000483 Helix-turn-helix domains; Region: HTH; cl00088 862259000484 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 862259000485 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 862259000486 motif 1; other site 862259000487 active site 862259000488 motif 2; other site 862259000489 motif 3; other site 862259000490 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 862259000491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862259000492 dimer interface [polypeptide binding]; other site 862259000493 conserved gate region; other site 862259000494 putative PBP binding loops; other site 862259000495 ABC-ATPase subunit interface; other site 862259000496 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 862259000497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862259000498 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000499 AAA domain; Region: AAA_23; pfam13476 862259000500 Walker A/P-loop; other site 862259000501 ATP binding site [chemical binding]; other site 862259000502 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 862259000503 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862259000504 Q-loop/lid; other site 862259000505 ABC transporter signature motif; other site 862259000506 Walker B; other site 862259000507 D-loop; other site 862259000508 H-loop/switch region; other site 862259000509 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862259000510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000511 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 862259000512 Walker A/P-loop; other site 862259000513 ATP binding site [chemical binding]; other site 862259000514 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862259000515 Q-loop/lid; other site 862259000516 ABC transporter signature motif; other site 862259000517 Walker B; other site 862259000518 D-loop; other site 862259000519 H-loop/switch region; other site 862259000520 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862259000521 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 862259000522 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 862259000523 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 862259000524 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 862259000525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259000526 RelB antitoxin; Region: RelB; cl01171 862259000527 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 862259000528 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000529 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 862259000530 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000531 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 862259000532 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862259000533 motif II; other site 862259000534 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862259000535 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 862259000536 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 862259000537 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 862259000538 HTH-like domain; Region: HTH_21; pfam13276 862259000539 Integrase core domain; Region: rve; cl01316 862259000540 Integrase core domain; Region: rve_3; cl15866 862259000541 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 862259000542 Helix-turn-helix domains; Region: HTH; cl00088 862259000543 Helix-turn-helix domains; Region: HTH; cl00088 862259000544 beta-phosphoglucomutase; Region: bPGM; TIGR01990 862259000545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862259000546 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 862259000547 homodimer interface [polypeptide binding]; other site 862259000548 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 862259000549 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 862259000550 active site 862259000551 homodimer interface [polypeptide binding]; other site 862259000552 catalytic site [active] 862259000553 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 862259000554 homodimer interface [polypeptide binding]; other site 862259000555 maltodextrin glucosidase; Provisional; Region: PRK10785 862259000556 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 862259000557 active site 862259000558 homodimer interface [polypeptide binding]; other site 862259000559 catalytic site [active] 862259000560 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 862259000561 reticulocyte binding protein 2-like protein; Provisional; Region: PTZ00440 862259000562 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 862259000563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862259000564 dimer interface [polypeptide binding]; other site 862259000565 conserved gate region; other site 862259000566 putative PBP binding loops; other site 862259000567 ABC-ATPase subunit interface; other site 862259000568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862259000569 dimer interface [polypeptide binding]; other site 862259000570 conserved gate region; other site 862259000571 putative PBP binding loops; other site 862259000572 ABC-ATPase subunit interface; other site 862259000573 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 862259000574 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 862259000575 Walker A/P-loop; other site 862259000576 ATP binding site [chemical binding]; other site 862259000577 Q-loop/lid; other site 862259000578 ABC transporter signature motif; other site 862259000579 Walker B; other site 862259000580 D-loop; other site 862259000581 H-loop/switch region; other site 862259000582 maltose phosphorylase; Provisional; Region: PRK13807 862259000583 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 862259000584 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 862259000585 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 862259000586 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 862259000587 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 862259000588 Ca binding site [ion binding]; other site 862259000589 active site 862259000590 catalytic site [active] 862259000591 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 862259000592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862259000593 DNA-binding site [nucleotide binding]; DNA binding site 862259000594 UTRA domain; Region: UTRA; cl01230 862259000595 oligoendopeptidase F; Region: pepF; TIGR00181 862259000596 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 862259000597 active site 862259000598 Zn binding site [ion binding]; other site 862259000599 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 862259000600 interface (dimer of trimers) [polypeptide binding]; other site 862259000601 Substrate-binding/catalytic site; other site 862259000602 Zn-binding sites [ion binding]; other site 862259000603 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 862259000604 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000605 Chromate transporter; Region: Chromate_transp; pfam02417 862259000606 Chromate transporter; Region: Chromate_transp; pfam02417 862259000607 Abi-like protein; Region: Abi_2; cl01988 862259000608 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862259000609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862259000610 dimer interface [polypeptide binding]; other site 862259000611 conserved gate region; other site 862259000612 putative PBP binding loops; other site 862259000613 ABC-ATPase subunit interface; other site 862259000614 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862259000615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862259000616 dimer interface [polypeptide binding]; other site 862259000617 conserved gate region; other site 862259000618 putative PBP binding loops; other site 862259000619 ABC-ATPase subunit interface; other site 862259000620 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862259000621 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 862259000622 Walker A/P-loop; other site 862259000623 ATP binding site [chemical binding]; other site 862259000624 Q-loop/lid; other site 862259000625 ABC transporter signature motif; other site 862259000626 Walker B; other site 862259000627 D-loop; other site 862259000628 H-loop/switch region; other site 862259000629 ribosomal protein L20; Region: rpl20; CHL00068 862259000630 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 862259000631 23S rRNA binding site [nucleotide binding]; other site 862259000632 L21 binding site [polypeptide binding]; other site 862259000633 L13 binding site [polypeptide binding]; other site 862259000634 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 862259000635 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 862259000636 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 862259000637 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 862259000638 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 862259000639 active site 862259000640 catalytic residues [active] 862259000641 metal binding site [ion binding]; metal-binding site 862259000642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 862259000643 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 862259000644 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 862259000645 catalytic site [active] 862259000646 G-X2-G-X-G-K; other site 862259000647 16S rRNA methyltransferase B; Provisional; Region: PRK14902 862259000648 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 862259000649 putative RNA binding site [nucleotide binding]; other site 862259000650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862259000651 S-adenosylmethionine binding site [chemical binding]; other site 862259000652 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 862259000653 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 862259000654 cofactor binding site; other site 862259000655 DNA binding site [nucleotide binding] 862259000656 substrate interaction site [chemical binding]; other site 862259000657 Eco47II restriction endonuclease; Region: RE_Eco47II; pfam09553 862259000658 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 862259000659 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 862259000660 G1 box; other site 862259000661 putative GEF interaction site [polypeptide binding]; other site 862259000662 GTP/Mg2+ binding site [chemical binding]; other site 862259000663 Switch I region; other site 862259000664 G2 box; other site 862259000665 G3 box; other site 862259000666 Switch II region; other site 862259000667 G4 box; other site 862259000668 G5 box; other site 862259000669 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 862259000670 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 862259000671 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259000672 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259000673 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 862259000674 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000675 Walker A motif; other site 862259000676 ATP binding site [chemical binding]; other site 862259000677 Walker B motif; other site 862259000678 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259000679 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259000680 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259000681 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 862259000682 dimer interface [polypeptide binding]; other site 862259000683 ssDNA binding site [nucleotide binding]; other site 862259000684 tetramer (dimer of dimers) interface [polypeptide binding]; other site 862259000685 Domain of unknown function (DUF955); Region: DUF955; cl01076 862259000686 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259000687 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259000688 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259000689 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 862259000690 AAA-like domain; Region: AAA_10; pfam12846 862259000691 Domain of unknown function DUF87; Region: DUF87; pfam01935 862259000692 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862259000693 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000694 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000695 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 862259000696 FtsX-like permease family; Region: FtsX; cl15850 862259000697 FtsX-like permease family; Region: FtsX; cl15850 862259000698 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 862259000699 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 862259000700 Protein phosphatase 2C; Region: PP2C; pfam00481 862259000701 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 862259000702 active site 862259000703 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 862259000704 Catalytic domain of Protein Kinases; Region: PKc; cd00180 862259000705 active site 862259000706 ATP binding site [chemical binding]; other site 862259000707 substrate binding site [chemical binding]; other site 862259000708 activation loop (A-loop); other site 862259000709 GTPase RsgA; Reviewed; Region: PRK00098 862259000710 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 862259000711 RNA binding site [nucleotide binding]; other site 862259000712 homodimer interface [polypeptide binding]; other site 862259000713 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 862259000714 GTPase/Zn-binding domain interface [polypeptide binding]; other site 862259000715 GTP/Mg2+ binding site [chemical binding]; other site 862259000716 G4 box; other site 862259000717 G5 box; other site 862259000718 G1 box; other site 862259000719 Switch I region; other site 862259000720 G2 box; other site 862259000721 G3 box; other site 862259000722 Switch II region; other site 862259000723 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 862259000724 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 862259000725 substrate binding site [chemical binding]; other site 862259000726 hexamer interface [polypeptide binding]; other site 862259000727 metal binding site [ion binding]; metal-binding site 862259000728 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 862259000729 Thiamine pyrophosphokinase; Region: TPK; cd07995 862259000730 active site 862259000731 dimerization interface [polypeptide binding]; other site 862259000732 thiamine binding site [chemical binding]; other site 862259000733 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 862259000734 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862259000735 active site 862259000736 HIGH motif; other site 862259000737 nucleotide binding site [chemical binding]; other site 862259000738 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 862259000739 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 862259000740 active site 862259000741 KMSKS motif; other site 862259000742 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 862259000743 tRNA binding surface [nucleotide binding]; other site 862259000744 anticodon binding site; other site 862259000745 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 862259000746 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 862259000747 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 862259000748 classical (c) SDRs; Region: SDR_c; cd05233 862259000749 NAD(P) binding site [chemical binding]; other site 862259000750 active site 862259000751 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 862259000752 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862259000753 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 862259000754 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 862259000755 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 862259000756 GIY-YIG motif/motif A; other site 862259000757 active site 862259000758 catalytic site [active] 862259000759 putative DNA binding site [nucleotide binding]; other site 862259000760 metal binding site [ion binding]; metal-binding site 862259000761 UvrB/uvrC motif; Region: UVR; pfam02151 862259000762 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 862259000763 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 862259000764 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 862259000765 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 862259000766 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 862259000767 classical (c) SDRs; Region: SDR_c; cd05233 862259000768 NAD(P) binding site [chemical binding]; other site 862259000769 active site 862259000770 Predicted GTPase [General function prediction only]; Region: COG0218 862259000771 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 862259000772 G1 box; other site 862259000773 GTP/Mg2+ binding site [chemical binding]; other site 862259000774 Switch I region; other site 862259000775 G2 box; other site 862259000776 G3 box; other site 862259000777 Switch II region; other site 862259000778 G4 box; other site 862259000779 G5 box; other site 862259000780 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 862259000781 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 862259000782 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862259000783 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 862259000784 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862259000785 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862259000786 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 862259000787 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 862259000788 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259000789 ATP-grasp domain; Region: ATP-grasp_4; cl03087 862259000790 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 862259000791 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259000792 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 862259000793 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259000794 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259000795 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 862259000796 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 862259000797 Active site serine [active] 862259000798 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 862259000799 THUMP domain; Region: THUMP; cl12076 862259000800 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 862259000801 Ligand Binding Site [chemical binding]; other site 862259000802 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 862259000803 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 862259000804 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862259000805 RNA binding surface [nucleotide binding]; other site 862259000806 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 862259000807 DAK2 domain; Region: Dak2; cl03685 862259000808 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 862259000809 HPr interaction site; other site 862259000810 glycerol kinase (GK) interaction site [polypeptide binding]; other site 862259000811 active site 862259000812 phosphorylation site [posttranslational modification] 862259000813 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 862259000814 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 862259000815 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 862259000816 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 862259000817 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964 862259000818 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862259000819 active site 862259000820 nucleotide binding site [chemical binding]; other site 862259000821 HIGH motif; other site 862259000822 KMSKS motif; other site 862259000823 Putative peptidase (DUF31); Region: DUF31; pfam01732 862259000824 Acetokinase family; Region: Acetate_kinase; cl01029 862259000825 propionate/acetate kinase; Provisional; Region: PRK12379 862259000826 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 862259000827 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 862259000828 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 862259000829 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862259000830 E3 interaction surface; other site 862259000831 lipoyl attachment site [posttranslational modification]; other site 862259000832 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 862259000833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259000834 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862259000835 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 862259000836 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 862259000837 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862259000838 E3 interaction surface; other site 862259000839 lipoyl attachment site [posttranslational modification]; other site 862259000840 e3 binding domain; Region: E3_binding; pfam02817 862259000841 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 862259000842 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 862259000843 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 862259000844 alpha subunit interface [polypeptide binding]; other site 862259000845 TPP binding site [chemical binding]; other site 862259000846 heterodimer interface [polypeptide binding]; other site 862259000847 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862259000848 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 862259000849 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 862259000850 tetramer interface [polypeptide binding]; other site 862259000851 TPP-binding site [chemical binding]; other site 862259000852 heterodimer interface [polypeptide binding]; other site 862259000853 phosphorylation loop region [posttranslational modification] 862259000854 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 862259000855 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 862259000856 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 862259000857 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 862259000858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259000859 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862259000860 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 862259000861 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 862259000862 Divergent AAA domain; Region: AAA_4; pfam04326 862259000863 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 862259000864 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 862259000865 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 862259000866 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 862259000867 active site 862259000868 dimer interface [polypeptide binding]; other site 862259000869 motif 1; other site 862259000870 motif 2; other site 862259000871 motif 3; other site 862259000872 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 862259000873 anticodon binding site; other site 862259000874 pyruvate kinase; Provisional; Region: PRK05826 862259000875 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 862259000876 domain interfaces; other site 862259000877 active site 862259000878 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 862259000879 active site 862259000880 ADP/pyrophosphate binding site [chemical binding]; other site 862259000881 dimerization interface [polypeptide binding]; other site 862259000882 allosteric effector site; other site 862259000883 fructose-1,6-bisphosphate binding site; other site 862259000884 Predicted dehydrogenase [General function prediction only]; Region: COG0579 862259000885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259000886 glycerol kinase; Provisional; Region: glpK; PRK00047 862259000887 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 862259000888 N- and C-terminal domain interface [polypeptide binding]; other site 862259000889 active site 862259000890 MgATP binding site [chemical binding]; other site 862259000891 catalytic site [active] 862259000892 metal binding site [ion binding]; metal-binding site 862259000893 glycerol binding site [chemical binding]; other site 862259000894 homotetramer interface [polypeptide binding]; other site 862259000895 homodimer interface [polypeptide binding]; other site 862259000896 FBP binding site [chemical binding]; other site 862259000897 protein IIAGlc interface [polypeptide binding]; other site 862259000898 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 862259000899 amphipathic channel; other site 862259000900 Asn-Pro-Ala signature motifs; other site 862259000901 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862259000902 active site 862259000903 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 862259000904 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 862259000905 active site 862259000906 enolase; Provisional; Region: eno; PRK00077 862259000907 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 862259000908 dimer interface [polypeptide binding]; other site 862259000909 metal binding site [ion binding]; metal-binding site 862259000910 substrate binding pocket [chemical binding]; other site 862259000911 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 862259000912 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 862259000913 putative active site [active] 862259000914 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 862259000915 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 862259000916 active site turn [active] 862259000917 phosphorylation site [posttranslational modification] 862259000918 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259000919 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 862259000920 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 862259000921 putative active site [active] 862259000922 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 862259000923 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862259000924 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000925 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000926 AAA-like domain; Region: AAA_10; pfam12846 862259000927 Domain of unknown function DUF87; Region: DUF87; pfam01935 862259000928 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259000929 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259000930 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259000931 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 862259000932 Domain of unknown function (DUF955); Region: DUF955; cl01076 862259000933 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 862259000934 dimer interface [polypeptide binding]; other site 862259000935 ssDNA binding site [nucleotide binding]; other site 862259000936 tetramer (dimer of dimers) interface [polypeptide binding]; other site 862259000937 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259000938 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259000939 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259000940 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 862259000941 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259000942 Walker A motif; other site 862259000943 ATP binding site [chemical binding]; other site 862259000944 Walker B motif; other site 862259000945 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 862259000946 active site 862259000947 phosphorylation site [posttranslational modification] 862259000948 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 862259000949 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 862259000950 P-loop; other site 862259000951 active site 862259000952 phosphorylation site [posttranslational modification] 862259000953 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259000954 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 862259000955 prolyl-tRNA synthetase; Provisional; Region: PRK08661 862259000956 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 862259000957 dimer interface [polypeptide binding]; other site 862259000958 motif 1; other site 862259000959 active site 862259000960 motif 2; other site 862259000961 motif 3; other site 862259000962 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 862259000963 anticodon binding site; other site 862259000964 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 862259000965 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 862259000966 RNA/DNA hybrid binding site [nucleotide binding]; other site 862259000967 active site 862259000968 GTP-binding protein LepA; Provisional; Region: PRK05433 862259000969 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 862259000970 G1 box; other site 862259000971 putative GEF interaction site [polypeptide binding]; other site 862259000972 GTP/Mg2+ binding site [chemical binding]; other site 862259000973 Switch I region; other site 862259000974 G2 box; other site 862259000975 G3 box; other site 862259000976 Switch II region; other site 862259000977 G4 box; other site 862259000978 G5 box; other site 862259000979 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 862259000980 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 862259000981 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 862259000982 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 862259000983 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 862259000984 dimer interface [polypeptide binding]; other site 862259000985 anticodon binding site; other site 862259000986 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 862259000987 homodimer interface [polypeptide binding]; other site 862259000988 motif 1; other site 862259000989 active site 862259000990 motif 2; other site 862259000991 GAD domain; Region: GAD; pfam02938 862259000992 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 862259000993 active site 862259000994 motif 3; other site 862259000995 histidyl-tRNA synthetase; Region: hisS; TIGR00442 862259000996 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 862259000997 dimer interface [polypeptide binding]; other site 862259000998 motif 1; other site 862259000999 active site 862259001000 motif 2; other site 862259001001 motif 3; other site 862259001002 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 862259001003 anticodon binding site; other site 862259001004 Ribosome-binding factor A; Region: RBFA; cl00542 862259001005 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 862259001006 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 862259001007 RNA binding site [nucleotide binding]; other site 862259001008 active site 862259001009 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862259001010 active site 862259001011 nucleotide binding site [chemical binding]; other site 862259001012 HIGH motif; other site 862259001013 KMSKS motif; other site 862259001014 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 862259001015 Active site serine [active] 862259001016 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 862259001017 Active site serine [active] 862259001018 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 862259001019 16S/18S rRNA binding site [nucleotide binding]; other site 862259001020 S13e-L30e interaction site [polypeptide binding]; other site 862259001021 25S rRNA binding site [nucleotide binding]; other site 862259001022 translation initiation factor IF-2; Region: IF-2; TIGR00487 862259001023 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 862259001024 G1 box; other site 862259001025 putative GEF interaction site [polypeptide binding]; other site 862259001026 GTP/Mg2+ binding site [chemical binding]; other site 862259001027 Switch I region; other site 862259001028 G2 box; other site 862259001029 G3 box; other site 862259001030 Switch II region; other site 862259001031 G4 box; other site 862259001032 G5 box; other site 862259001033 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 862259001034 Translation-initiation factor 2; Region: IF-2; pfam11987 862259001035 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 862259001036 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 862259001037 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 862259001038 putative RNA binding cleft [nucleotide binding]; other site 862259001039 transcription termination factor NusA; Region: NusA; TIGR01953 862259001040 NusA N-terminal domain; Region: NusA_N; pfam08529 862259001041 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 862259001042 RNA binding site [nucleotide binding]; other site 862259001043 homodimer interface [polypeptide binding]; other site 862259001044 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 862259001045 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 862259001046 G-X-X-G motif; other site 862259001047 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 862259001048 Sm1 motif; other site 862259001049 D3 - B interaction site; other site 862259001050 D1 - D2 interaction site; other site 862259001051 Hfq - Hfq interaction site; other site 862259001052 RNA binding pocket [nucleotide binding]; other site 862259001053 Sm2 motif; other site 862259001054 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 862259001055 dimer interface [polypeptide binding]; other site 862259001056 FMN binding site [chemical binding]; other site 862259001057 DNA polymerase III PolC; Validated; Region: polC; PRK00448 862259001058 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 862259001059 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 862259001060 generic binding surface II; other site 862259001061 generic binding surface I; other site 862259001062 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 862259001063 active site 862259001064 substrate binding site [chemical binding]; other site 862259001065 catalytic site [active] 862259001066 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 862259001067 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 862259001068 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 862259001069 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 862259001070 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 862259001071 active site 862259001072 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 862259001073 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 862259001074 active site 862259001075 HIGH motif; other site 862259001076 dimer interface [polypeptide binding]; other site 862259001077 KMSKS motif; other site 862259001078 HTH-like domain; Region: HTH_21; pfam13276 862259001079 Integrase core domain; Region: rve; cl01316 862259001080 Integrase core domain; Region: rve_3; cl15866 862259001081 Helix-turn-helix domains; Region: HTH; cl00088 862259001082 Helix-turn-helix domains; Region: HTH; cl00088 862259001083 RmuC family; Region: RmuC; pfam02646 862259001084 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 862259001085 active site 862259001086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259001087 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 862259001088 transketolase; Reviewed; Region: PRK05899 862259001089 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 862259001090 TPP-binding site [chemical binding]; other site 862259001091 dimer interface [polypeptide binding]; other site 862259001092 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862259001093 PYR/PP interface [polypeptide binding]; other site 862259001094 dimer interface [polypeptide binding]; other site 862259001095 TPP binding site [chemical binding]; other site 862259001096 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862259001097 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 862259001098 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 862259001099 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259001100 ATP binding site [chemical binding]; other site 862259001101 putative Mg++ binding site [ion binding]; other site 862259001102 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 862259001103 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862259001104 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 862259001105 Divergent AAA domain; Region: AAA_4; pfam04326 862259001106 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 862259001107 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001108 Helix-turn-helix domains; Region: HTH; cl00088 862259001109 Helix-turn-helix domains; Region: HTH; cl00088 862259001110 HTH-like domain; Region: HTH_21; pfam13276 862259001111 Integrase core domain; Region: rve; cl01316 862259001112 Integrase core domain; Region: rve_3; cl15866 862259001113 Helix-turn-helix domains; Region: HTH; cl00088 862259001114 HTH-like domain; Region: HTH_21; pfam13276 862259001115 Integrase core domain; Region: rve; cl01316 862259001116 Integrase core domain; Region: rve_3; cl15866 862259001117 ScpA/B protein; Region: ScpA_ScpB; cl00598 862259001118 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 862259001119 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 862259001120 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862259001121 RNA binding surface [nucleotide binding]; other site 862259001122 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 862259001123 active site 862259001124 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 862259001125 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 862259001126 Substrate-binding site [chemical binding]; other site 862259001127 Substrate specificity [chemical binding]; other site 862259001128 Transcriptional regulator; Region: Transcrip_reg; cl00361 862259001129 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 862259001130 active site 862259001131 phosphorylation site [posttranslational modification] 862259001132 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 862259001133 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 862259001134 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 862259001135 P-loop; other site 862259001136 active site 862259001137 phosphorylation site [posttranslational modification] 862259001138 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862259001139 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259001140 Walker A/P-loop; other site 862259001141 ATP binding site [chemical binding]; other site 862259001142 Q-loop/lid; other site 862259001143 ABC transporter signature motif; other site 862259001144 Walker B; other site 862259001145 D-loop; other site 862259001146 H-loop/switch region; other site 862259001147 Mediator complex subunit 15; Region: Med15_fungi; pfam05397 862259001148 Uncharacterized conserved protein [Function unknown]; Region: COG2433 862259001149 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 862259001150 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 862259001151 dimer interface [polypeptide binding]; other site 862259001152 substrate binding site [chemical binding]; other site 862259001153 metal binding sites [ion binding]; metal-binding site 862259001154 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 862259001155 cytidylate kinase; Provisional; Region: cmk; PRK00023 862259001156 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 862259001157 CMP-binding site; other site 862259001158 The sites determining sugar specificity; other site 862259001159 GTP-binding protein Der; Reviewed; Region: PRK00093 862259001160 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 862259001161 G1 box; other site 862259001162 GTP/Mg2+ binding site [chemical binding]; other site 862259001163 Switch I region; other site 862259001164 G2 box; other site 862259001165 Switch II region; other site 862259001166 G3 box; other site 862259001167 G4 box; other site 862259001168 G5 box; other site 862259001169 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 862259001170 G1 box; other site 862259001171 GTP/Mg2+ binding site [chemical binding]; other site 862259001172 Switch I region; other site 862259001173 G2 box; other site 862259001174 G3 box; other site 862259001175 Switch II region; other site 862259001176 G4 box; other site 862259001177 G5 box; other site 862259001178 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 862259001179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259001180 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 862259001181 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 862259001182 IHF dimer interface [polypeptide binding]; other site 862259001183 IHF - DNA interface [nucleotide binding]; other site 862259001184 Recombination protein U; Region: RecU; cl01314 862259001185 cell division protein GpsB; Provisional; Region: PRK14127 862259001186 DivIVA domain; Region: DivI1A_domain; TIGR03544 862259001187 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 862259001188 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001189 DNA polymerase III PolC; Validated; Region: polC; PRK00448 862259001190 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001191 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259001192 Competence-damaged protein; Region: CinA; cl00666 862259001193 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 862259001194 protein RecA; Region: tigrfam_recA; TIGR02012 862259001195 hexamer interface [polypeptide binding]; other site 862259001196 Walker A motif; other site 862259001197 ATP binding site [chemical binding]; other site 862259001198 Walker B motif; other site 862259001199 phosphodiesterase; Provisional; Region: PRK12704 862259001200 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 862259001201 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 862259001202 signal recognition particle protein; Region: ffh; TIGR00959 862259001203 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 862259001204 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 862259001205 P loop; other site 862259001206 GTP binding site [chemical binding]; other site 862259001207 Signal peptide binding domain; Region: SRP_SPB; pfam02978 862259001208 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 862259001209 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 862259001210 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 862259001211 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 862259001212 RimM N-terminal domain; Region: RimM; pfam01782 862259001213 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 862259001214 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 862259001215 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 862259001216 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 862259001217 GTP/Mg2+ binding site [chemical binding]; other site 862259001218 G4 box; other site 862259001219 G5 box; other site 862259001220 G1 box; other site 862259001221 Switch I region; other site 862259001222 G2 box; other site 862259001223 G3 box; other site 862259001224 Switch II region; other site 862259001225 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 862259001226 RNA/DNA hybrid binding site [nucleotide binding]; other site 862259001227 active site 862259001228 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 862259001229 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 862259001230 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862259001231 active site residue [active] 862259001232 putative inner membrane protein; Provisional; Region: PRK11099 862259001233 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 862259001234 generic binding surface II; other site 862259001235 generic binding surface I; other site 862259001236 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862259001237 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862259001238 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 862259001239 Walker A/P-loop; other site 862259001240 ATP binding site [chemical binding]; other site 862259001241 Q-loop/lid; other site 862259001242 ABC transporter signature motif; other site 862259001243 Walker B; other site 862259001244 D-loop; other site 862259001245 H-loop/switch region; other site 862259001246 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862259001247 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 862259001248 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 862259001249 Walker A/P-loop; other site 862259001250 ATP binding site [chemical binding]; other site 862259001251 Q-loop/lid; other site 862259001252 ABC transporter signature motif; other site 862259001253 Walker B; other site 862259001254 D-loop; other site 862259001255 H-loop/switch region; other site 862259001256 GTPase CgtA; Reviewed; Region: obgE; PRK12297 862259001257 GTP1/OBG; Region: GTP1_OBG; pfam01018 862259001258 Obg GTPase; Region: Obg; cd01898 862259001259 G1 box; other site 862259001260 GTP/Mg2+ binding site [chemical binding]; other site 862259001261 Switch I region; other site 862259001262 G2 box; other site 862259001263 G3 box; other site 862259001264 Switch II region; other site 862259001265 G4 box; other site 862259001266 G5 box; other site 862259001267 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 862259001268 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 862259001269 NAD synthase; Region: NAD_synthase; pfam02540 862259001270 homodimer interface [polypeptide binding]; other site 862259001271 NAD binding pocket [chemical binding]; other site 862259001272 ATP binding pocket [chemical binding]; other site 862259001273 Mg binding site [ion binding]; other site 862259001274 active-site loop [active] 862259001275 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 862259001276 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 862259001277 active site 862259001278 (T/H)XGH motif; other site 862259001279 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 862259001280 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 862259001281 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 862259001282 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 862259001283 Substrate-binding site [chemical binding]; other site 862259001284 Substrate specificity [chemical binding]; other site 862259001285 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 862259001286 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 862259001287 Helix-turn-helix domains; Region: HTH; cl00088 862259001288 HTH-like domain; Region: HTH_21; pfam13276 862259001289 Integrase core domain; Region: rve; cl01316 862259001290 Integrase core domain; Region: rve_3; cl15866 862259001291 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 862259001292 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 862259001293 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 862259001294 putative active site [active] 862259001295 substrate binding site [chemical binding]; other site 862259001296 putative cosubstrate binding site; other site 862259001297 catalytic site [active] 862259001298 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 862259001299 substrate binding site [chemical binding]; other site 862259001300 translation elongation factor P; Region: efp; TIGR00038 862259001301 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 862259001302 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 862259001303 RNA binding site [nucleotide binding]; other site 862259001304 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 862259001305 RNA binding site [nucleotide binding]; other site 862259001306 trigger factor; Region: tig; TIGR00115 862259001307 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 862259001308 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 862259001309 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 862259001310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862259001311 Walker A motif; other site 862259001312 ATP binding site [chemical binding]; other site 862259001313 Walker B motif; other site 862259001314 arginine finger; other site 862259001315 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 862259001316 recombination factor protein RarA; Reviewed; Region: PRK13342 862259001317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862259001318 Walker A motif; other site 862259001319 ATP binding site [chemical binding]; other site 862259001320 Walker B motif; other site 862259001321 arginine finger; other site 862259001322 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 862259001323 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 862259001324 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 862259001325 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 862259001326 FtsX-like permease family; Region: FtsX; cl15850 862259001327 DJ-1 family protein; Region: not_thiJ; TIGR01383 862259001328 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 862259001329 conserved cys residue [active] 862259001330 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 862259001331 putative active site [active] 862259001332 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 862259001333 GTPase Era; Reviewed; Region: era; PRK00089 862259001334 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 862259001335 G1 box; other site 862259001336 GTP/Mg2+ binding site [chemical binding]; other site 862259001337 Switch I region; other site 862259001338 G2 box; other site 862259001339 Switch II region; other site 862259001340 G3 box; other site 862259001341 G4 box; other site 862259001342 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 862259001343 Recombination protein O N terminal; Region: RecO_N; cl15812 862259001344 DNA repair protein RecO; Region: reco; TIGR00613 862259001345 Recombination protein O C terminal; Region: RecO_C; pfam02565 862259001346 glycyl-tRNA synthetase; Provisional; Region: PRK04173 862259001347 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 862259001348 dimer interface [polypeptide binding]; other site 862259001349 motif 1; other site 862259001350 active site 862259001351 motif 2; other site 862259001352 motif 3; other site 862259001353 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 862259001354 anticodon binding site; other site 862259001355 DNA primase, catalytic core; Region: dnaG; TIGR01391 862259001356 CHC2 zinc finger; Region: zf-CHC2; cl15369 862259001357 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 862259001358 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 862259001359 active site 862259001360 metal binding site [ion binding]; metal-binding site 862259001361 interdomain interaction site; other site 862259001362 DNA polymerase III PolC; Validated; Region: polC; PRK00448 862259001363 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 862259001364 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862259001365 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 862259001366 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862259001367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259001368 Uncharacterized conserved protein [Function unknown]; Region: COG0327 862259001369 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 862259001370 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259001371 DEAD-like helicases superfamily; Region: DEXDc; smart00487 862259001372 ATP binding site [chemical binding]; other site 862259001373 putative Mg++ binding site [ion binding]; other site 862259001374 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862259001375 nucleotide binding region [chemical binding]; other site 862259001376 ATP-binding site [chemical binding]; other site 862259001377 Uncharacterized conserved protein [Function unknown]; Region: COG1284 862259001378 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 862259001379 Protein export membrane protein; Region: SecD_SecF; cl14618 862259001380 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 862259001381 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862259001382 active site 862259001383 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 862259001384 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 862259001385 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 862259001386 synthetase active site [active] 862259001387 NTP binding site [chemical binding]; other site 862259001388 metal binding site [ion binding]; metal-binding site 862259001389 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 862259001390 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 862259001391 putative transposase OrfB; Reviewed; Region: PHA02517 862259001392 HTH-like domain; Region: HTH_21; pfam13276 862259001393 Integrase core domain; Region: rve; cl01316 862259001394 Integrase core domain; Region: rve_3; cl15866 862259001395 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259001396 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 862259001397 Walker A/P-loop; other site 862259001398 ATP binding site [chemical binding]; other site 862259001399 Q-loop/lid; other site 862259001400 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 862259001401 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259001402 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 862259001403 ABC transporter signature motif; other site 862259001404 Walker B; other site 862259001405 D-loop; other site 862259001406 H-loop/switch region; other site 862259001407 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 862259001408 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 862259001409 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 862259001410 dimerization interface [polypeptide binding]; other site 862259001411 active site 862259001412 metal binding site [ion binding]; metal-binding site 862259001413 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 862259001414 dsRNA binding site [nucleotide binding]; other site 862259001415 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 862259001416 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 862259001417 DAK2 domain; Region: Dak2; cl03685 862259001418 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 862259001419 Asp23 family; Region: Asp23; cl00574 862259001420 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 862259001421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862259001422 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 862259001423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862259001424 dimer interface [polypeptide binding]; other site 862259001425 conserved gate region; other site 862259001426 putative PBP binding loops; other site 862259001427 ABC-ATPase subunit interface; other site 862259001428 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 862259001429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862259001430 dimer interface [polypeptide binding]; other site 862259001431 conserved gate region; other site 862259001432 putative PBP binding loops; other site 862259001433 ABC-ATPase subunit interface; other site 862259001434 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 862259001435 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 862259001436 Walker A/P-loop; other site 862259001437 ATP binding site [chemical binding]; other site 862259001438 Q-loop/lid; other site 862259001439 ABC transporter signature motif; other site 862259001440 Walker B; other site 862259001441 D-loop; other site 862259001442 H-loop/switch region; other site 862259001443 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 862259001444 PhoU domain; Region: PhoU; pfam01895 862259001445 PhoU domain; Region: PhoU; pfam01895 862259001446 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 862259001447 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 862259001448 P loop; other site 862259001449 GTP binding site [chemical binding]; other site 862259001450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 862259001451 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 862259001452 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862259001453 putative active site [active] 862259001454 metal binding site [ion binding]; metal-binding site 862259001455 homodimer binding site [polypeptide binding]; other site 862259001456 S-adenosylmethionine synthetase; Validated; Region: PRK05250 862259001457 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 862259001458 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 862259001459 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 862259001460 CutC family; Region: CutC; cl01218 862259001461 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 862259001462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259001463 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 862259001464 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 862259001465 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 862259001466 ligand binding site [chemical binding]; other site 862259001467 active site 862259001468 UGI interface [polypeptide binding]; other site 862259001469 catalytic site [active] 862259001470 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 862259001471 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 862259001472 generic binding surface II; other site 862259001473 generic binding surface I; other site 862259001474 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 862259001475 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 862259001476 HIT family signature motif; other site 862259001477 catalytic residue [active] 862259001478 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 862259001479 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862259001480 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862259001481 catalytic residue [active] 862259001482 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 862259001483 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 862259001484 trimerization site [polypeptide binding]; other site 862259001485 active site 862259001486 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 862259001487 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 862259001488 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 862259001489 active site 862259001490 Zn binding site [ion binding]; other site 862259001491 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 862259001492 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 862259001493 active site 862259001494 dimer interface [polypeptide binding]; other site 862259001495 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 862259001496 dimer interface [polypeptide binding]; other site 862259001497 active site 862259001498 dUTPase; Region: dUTPase_2; pfam08761 862259001499 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 862259001500 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 862259001501 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 862259001502 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 862259001503 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 862259001504 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862259001505 tetrameric interface [polypeptide binding]; other site 862259001506 activator binding site; other site 862259001507 NADP binding site [chemical binding]; other site 862259001508 substrate binding site [chemical binding]; other site 862259001509 catalytic residues [active] 862259001510 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 862259001511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862259001512 Mg2+ binding site [ion binding]; other site 862259001513 G-X-G motif; other site 862259001514 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 862259001515 anchoring element; other site 862259001516 dimer interface [polypeptide binding]; other site 862259001517 ATP binding site [chemical binding]; other site 862259001518 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 862259001519 active site 862259001520 putative metal-binding site [ion binding]; other site 862259001521 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 862259001522 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 862259001523 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 862259001524 CAP-like domain; other site 862259001525 active site 862259001526 primary dimer interface [polypeptide binding]; other site 862259001527 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862259001528 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862259001529 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 862259001530 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259001531 Family description; Region: UvrD_C_2; cl15862 862259001532 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259001533 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 862259001534 Walker A/P-loop; other site 862259001535 ATP binding site [chemical binding]; other site 862259001536 Q-loop/lid; other site 862259001537 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259001538 ABC transporter signature motif; other site 862259001539 Walker B; other site 862259001540 D-loop; other site 862259001541 H-loop/switch region; other site 862259001542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862259001543 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 862259001544 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001545 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001546 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001547 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001548 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001549 Helix-turn-helix domains; Region: HTH; cl00088 862259001550 HTH-like domain; Region: HTH_21; pfam13276 862259001551 Integrase core domain; Region: rve; cl01316 862259001552 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 862259001553 putative active site [active] 862259001554 putative FMN binding site [chemical binding]; other site 862259001555 putative substrate binding site [chemical binding]; other site 862259001556 putative catalytic residue [active] 862259001557 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 862259001558 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 862259001559 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 862259001560 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 862259001561 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 862259001562 lipoyl attachment site [posttranslational modification]; other site 862259001563 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862259001564 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862259001565 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862259001566 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862259001567 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862259001568 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001569 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259001570 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 862259001571 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 862259001572 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 862259001573 Walker A/P-loop; other site 862259001574 ATP binding site [chemical binding]; other site 862259001575 Q-loop/lid; other site 862259001576 ABC transporter signature motif; other site 862259001577 Walker B; other site 862259001578 D-loop; other site 862259001579 H-loop/switch region; other site 862259001580 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 862259001581 tetramer (dimer of dimers) interface [polypeptide binding]; other site 862259001582 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 862259001583 NAD binding site [chemical binding]; other site 862259001584 dimer interface [polypeptide binding]; other site 862259001585 substrate binding site [chemical binding]; other site 862259001586 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 862259001587 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862259001588 active site 862259001589 Metallothionein; Region: Metallothionein; pfam05522 862259001590 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 862259001591 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 862259001592 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 862259001593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862259001594 Walker A motif; other site 862259001595 ATP binding site [chemical binding]; other site 862259001596 Walker B motif; other site 862259001597 arginine finger; other site 862259001598 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 862259001599 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 862259001600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259001601 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862259001602 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 862259001603 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 862259001604 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 862259001605 GTP/Mg2+ binding site [chemical binding]; other site 862259001606 G4 box; other site 862259001607 G5 box; other site 862259001608 G1 box; other site 862259001609 Switch I region; other site 862259001610 G2 box; other site 862259001611 G3 box; other site 862259001612 Switch II region; other site 862259001613 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 862259001614 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 862259001615 active site 862259001616 DNA binding site [nucleotide binding] 862259001617 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 862259001618 active site 862259001619 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 862259001620 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 862259001621 ATP-binding site [chemical binding]; other site 862259001622 Sugar specificity; other site 862259001623 Pyrimidine base specificity; other site 862259001624 hypothetical protein; Provisional; Region: PRK07205 862259001625 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 862259001626 active site 862259001627 metal binding site [ion binding]; metal-binding site 862259001628 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 862259001629 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 862259001630 putative active site cavity [active] 862259001631 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 862259001632 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 862259001633 Domain of unknown function (DUF386); Region: DUF386; cl01047 862259001634 Sodium:solute symporter family; Region: SSF; cl00456 862259001635 N-acetylneuraminate lyase; Region: nanA; TIGR00683 862259001636 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 862259001637 inhibitor site; inhibition site 862259001638 active site 862259001639 dimer interface [polypeptide binding]; other site 862259001640 catalytic residue [active] 862259001641 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 862259001642 Protein of unknown function (DUF464); Region: DUF464; cl01080 862259001643 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 862259001644 Predicted methyltransferases [General function prediction only]; Region: COG0313 862259001645 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 862259001646 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 862259001647 putative acyl-acceptor binding pocket; other site 862259001648 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 862259001649 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 862259001650 catalytic motif [active] 862259001651 Zn binding site [ion binding]; other site 862259001652 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 862259001653 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862259001654 RNA binding surface [nucleotide binding]; other site 862259001655 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 862259001656 active site 862259001657 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 862259001658 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 862259001659 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862259001660 active site 862259001661 HIGH motif; other site 862259001662 nucleotide binding site [chemical binding]; other site 862259001663 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862259001664 active site 862259001665 KMSKS motif; other site 862259001666 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 862259001667 tRNA binding surface [nucleotide binding]; other site 862259001668 anticodon binding site; other site 862259001669 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862259001670 Protein of unknown function (DUF552); Region: DUF552; cl00775 862259001671 cell division protein FtsZ; Provisional; Region: PRK13018 862259001672 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 862259001673 nucleotide binding site [chemical binding]; other site 862259001674 SulA interaction site; other site 862259001675 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 862259001676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259001677 cell division protein MraZ; Reviewed; Region: PRK00326 862259001678 MraZ protein; Region: MraZ; pfam02381 862259001679 MraZ protein; Region: MraZ; pfam02381 862259001680 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 862259001681 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 862259001682 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 862259001683 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 862259001684 putative tRNA-binding site [nucleotide binding]; other site 862259001685 B3/4 domain; Region: B3_4; cl11458 862259001686 tRNA synthetase B5 domain; Region: B5; cl08394 862259001687 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 862259001688 dimer interface [polypeptide binding]; other site 862259001689 motif 1; other site 862259001690 motif 3; other site 862259001691 motif 2; other site 862259001692 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 862259001693 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 862259001694 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 862259001695 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 862259001696 dimer interface [polypeptide binding]; other site 862259001697 motif 1; other site 862259001698 active site 862259001699 motif 2; other site 862259001700 motif 3; other site 862259001701 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 862259001702 FtsX-like permease family; Region: FtsX; cl15850 862259001703 FtsX-like permease family; Region: FtsX; cl15850 862259001704 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 862259001705 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 862259001706 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 862259001707 active site 862259001708 HIGH motif; other site 862259001709 KMSK motif region; other site 862259001710 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 862259001711 tRNA binding surface [nucleotide binding]; other site 862259001712 anticodon binding site; other site 862259001713 ribosome recycling factor; Reviewed; Region: frr; PRK00083 862259001714 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 862259001715 hinge region; other site 862259001716 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 862259001717 putative nucleotide binding site [chemical binding]; other site 862259001718 uridine monophosphate binding site [chemical binding]; other site 862259001719 homohexameric interface [polypeptide binding]; other site 862259001720 elongation factor Ts; Provisional; Region: tsf; PRK09377 862259001721 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 862259001722 Elongation factor TS; Region: EF_TS; pfam00889 862259001723 Elongation factor TS; Region: EF_TS; pfam00889 862259001724 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 862259001725 rRNA interaction site [nucleotide binding]; other site 862259001726 S8 interaction site; other site 862259001727 putative laminin-1 binding site; other site 862259001728 chaperone protein DnaJ; Provisional; Region: PRK14296 862259001729 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 862259001730 HSP70 interaction site [polypeptide binding]; other site 862259001731 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 862259001732 Zn binding sites [ion binding]; other site 862259001733 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 862259001734 dimer interface [polypeptide binding]; other site 862259001735 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 862259001736 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 862259001737 dimer interface [polypeptide binding]; other site 862259001738 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 862259001739 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 862259001740 HrcA protein C terminal domain; Region: HrcA; pfam01628 862259001741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862259001742 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862259001743 Walker A motif; other site 862259001744 ATP binding site [chemical binding]; other site 862259001745 Walker B motif; other site 862259001746 arginine finger; other site 862259001747 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 862259001748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862259001749 Walker A motif; other site 862259001750 ATP binding site [chemical binding]; other site 862259001751 Walker B motif; other site 862259001752 arginine finger; other site 862259001753 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 862259001754 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 862259001755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862259001756 motif II; other site 862259001757 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 862259001758 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 862259001759 active site 862259001760 dimerization interface [polypeptide binding]; other site 862259001761 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 862259001762 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 862259001763 alpha subunit interaction interface [polypeptide binding]; other site 862259001764 Walker A motif; other site 862259001765 ATP binding site [chemical binding]; other site 862259001766 Walker B motif; other site 862259001767 inhibitor binding site; inhibition site 862259001768 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 862259001769 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 862259001770 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259001771 Walker A motif; other site 862259001772 ATP binding site [chemical binding]; other site 862259001773 Walker B motif; other site 862259001774 Protein of unknown function (DUF2714); Region: DUF2714; pfam10896 862259001775 Putative peptidase (DUF31); Region: DUF31; pfam01732 862259001776 Putative peptidase (DUF31); Region: DUF31; pfam01732 862259001777 Mycoplasma virulence signal region (Myco_arth_vir_N); Region: Myco_arth_vir_N; cl15438 862259001778 Putative peptidase (DUF31); Region: DUF31; pfam01732 862259001779 Mycoplasma virulence signal region (Myco_arth_vir_N); Region: Myco_arth_vir_N; cl15438 862259001780 Putative peptidase (DUF31); Region: DUF31; pfam01732 862259001781 Mycoplasma virulence signal region (Myco_arth_vir_N); Region: Myco_arth_vir_N; cl15438 862259001782 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 862259001783 active site 862259001784 catalytic triad [active] 862259001785 DNA polymerase III, gamma/tau subunits [DNA replication, recombination, and repair]; Region: DnaX; COG2812 862259001786 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862259001787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862259001788 Walker A motif; other site 862259001789 ATP binding site [chemical binding]; other site 862259001790 Walker B motif; other site 862259001791 arginine finger; other site 862259001792 hypothetical protein; Provisional; Region: PRK08185 862259001793 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 862259001794 intersubunit interface [polypeptide binding]; other site 862259001795 active site 862259001796 zinc binding site [ion binding]; other site 862259001797 Na+ binding site [ion binding]; other site 862259001798 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 862259001799 Helix-turn-helix domains; Region: HTH; cl00088 862259001800 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 862259001801 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 862259001802 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 862259001803 active site turn [active] 862259001804 phosphorylation site [posttranslational modification] 862259001805 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259001806 phosphodiesterase; Provisional; Region: PRK12704 862259001807 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 862259001808 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 862259001809 putative substrate binding site [chemical binding]; other site 862259001810 putative ATP binding site [chemical binding]; other site 862259001811 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 862259001812 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 862259001813 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 862259001814 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 862259001815 Divergent AAA domain; Region: AAA_4; pfam04326 862259001816 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 862259001817 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 862259001818 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 862259001819 MatE; Region: MatE; cl10513 862259001820 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 862259001821 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259001822 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 862259001823 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259001824 Family description; Region: UvrD_C_2; cl15862 862259001825 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 862259001826 putative active site [active] 862259001827 Fic family protein [Function unknown]; Region: COG3177 862259001828 Fic/DOC family; Region: Fic; cl00960 862259001829 Abi-like protein; Region: Abi_2; cl01988 862259001830 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001831 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259001832 Fic/DOC family; Region: Fic; cl00960 862259001833 conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319 862259001834 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 862259001835 2-oxoisovalerate dehydrogenase E2 component; Region: PLN02528 862259001836 e3 binding domain; Region: E3_binding; pfam02817 862259001837 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001838 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259001839 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001840 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259001841 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259001842 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001843 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259001844 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259001845 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001846 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259001847 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259001848 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259001849 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 862259001850 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 862259001851 generic binding surface I; other site 862259001852 generic binding surface II; other site 862259001853 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862259001854 Zn2+ binding site [ion binding]; other site 862259001855 Mg2+ binding site [ion binding]; other site 862259001856 replicative DNA helicase; Region: DnaB; TIGR00665 862259001857 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 862259001858 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 862259001859 Walker A motif; other site 862259001860 ATP binding site [chemical binding]; other site 862259001861 Walker B motif; other site 862259001862 DNA binding loops [nucleotide binding] 862259001863 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 862259001864 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 862259001865 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 862259001866 LemA family; Region: LemA; cl00742 862259001867 Phosphoglycerate kinase; Region: PGK; pfam00162 862259001868 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 862259001869 substrate binding site [chemical binding]; other site 862259001870 hinge regions; other site 862259001871 ADP binding site [chemical binding]; other site 862259001872 catalytic site [active] 862259001873 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 862259001874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259001875 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 862259001876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862259001877 Walker A motif; other site 862259001878 ATP binding site [chemical binding]; other site 862259001879 Walker B motif; other site 862259001880 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 862259001881 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 862259001882 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 862259001883 DNA binding site [nucleotide binding] 862259001884 catalytic residue [active] 862259001885 H2TH interface [polypeptide binding]; other site 862259001886 putative catalytic residues [active] 862259001887 turnover-facilitating residue; other site 862259001888 intercalation triad [nucleotide binding]; other site 862259001889 8OG recognition residue [nucleotide binding]; other site 862259001890 putative reading head residues; other site 862259001891 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 862259001892 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 862259001893 DNA polymerase I; Provisional; Region: PRK05755 862259001894 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 862259001895 active site 862259001896 metal binding site 1 [ion binding]; metal-binding site 862259001897 putative 5' ssDNA interaction site; other site 862259001898 metal binding site 3; metal-binding site 862259001899 metal binding site 2 [ion binding]; metal-binding site 862259001900 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 862259001901 putative DNA binding site [nucleotide binding]; other site 862259001902 putative metal binding site [ion binding]; other site 862259001903 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 862259001904 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 862259001905 active site 862259001906 DNA binding site [nucleotide binding] 862259001907 catalytic site [active] 862259001908 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 862259001909 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 862259001910 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 862259001911 generic binding surface I; other site 862259001912 generic binding surface II; other site 862259001913 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 862259001914 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 862259001915 active site 862259001916 HIGH motif; other site 862259001917 dimer interface [polypeptide binding]; other site 862259001918 KMSKS motif; other site 862259001919 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 862259001920 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 862259001921 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 862259001922 active site 862259001923 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 862259001924 putative tRNA-binding site [nucleotide binding]; other site 862259001925 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 862259001926 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 862259001927 Helix-turn-helix domains; Region: HTH; cl00088 862259001928 putative DNA binding helix; other site 862259001929 metal binding site 2 [ion binding]; metal-binding site 862259001930 metal binding site 1 [ion binding]; metal-binding site 862259001931 dimer interface [polypeptide binding]; other site 862259001932 structural Zn2+ binding site [ion binding]; other site 862259001933 carbamate kinase; Reviewed; Region: PRK12686 862259001934 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 862259001935 putative substrate binding site [chemical binding]; other site 862259001936 nucleotide binding site [chemical binding]; other site 862259001937 nucleotide binding site [chemical binding]; other site 862259001938 homodimer interface [polypeptide binding]; other site 862259001939 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 862259001940 agmatine deiminase; Region: agmatine_aguA; TIGR03380 862259001941 Amino acid permease; Region: AA_permease_2; pfam13520 862259001942 putrescine carbamoyltransferase; Provisional; Region: PRK02255 862259001943 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 862259001944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259001945 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862259001946 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 862259001947 Walker A/P-loop; other site 862259001948 ATP binding site [chemical binding]; other site 862259001949 Q-loop/lid; other site 862259001950 ABC transporter signature motif; other site 862259001951 Walker B; other site 862259001952 D-loop; other site 862259001953 H-loop/switch region; other site 862259001954 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 862259001955 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 862259001956 HIGH motif; other site 862259001957 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 862259001958 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862259001959 active site 862259001960 KMSKS motif; other site 862259001961 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 862259001962 tRNA binding surface [nucleotide binding]; other site 862259001963 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 862259001964 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 862259001965 23S rRNA interface [nucleotide binding]; other site 862259001966 L3 interface [polypeptide binding]; other site 862259001967 FtsX-like permease family; Region: FtsX; cl15850 862259001968 FtsX-like permease family; Region: FtsX; cl15850 862259001969 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 862259001970 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 862259001971 dimerization interface 3.5A [polypeptide binding]; other site 862259001972 active site 862259001973 Cobalt transport protein; Region: CbiQ; cl00463 862259001974 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13645 862259001975 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 862259001976 Walker A/P-loop; other site 862259001977 ATP binding site [chemical binding]; other site 862259001978 Q-loop/lid; other site 862259001979 ABC transporter signature motif; other site 862259001980 Walker B; other site 862259001981 D-loop; other site 862259001982 H-loop/switch region; other site 862259001983 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 862259001984 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 862259001985 Walker A/P-loop; other site 862259001986 ATP binding site [chemical binding]; other site 862259001987 Q-loop/lid; other site 862259001988 ABC transporter signature motif; other site 862259001989 Walker B; other site 862259001990 D-loop; other site 862259001991 H-loop/switch region; other site 862259001992 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 862259001993 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 862259001994 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 862259001995 alphaNTD homodimer interface [polypeptide binding]; other site 862259001996 alphaNTD - beta interaction site [polypeptide binding]; other site 862259001997 alphaNTD - beta' interaction site [polypeptide binding]; other site 862259001998 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 862259001999 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 862259002000 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 862259002001 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 862259002002 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 862259002003 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 862259002004 rRNA binding site [nucleotide binding]; other site 862259002005 predicted 30S ribosome binding site; other site 862259002006 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 862259002007 active site 862259002008 adenylate kinases; Region: adk; TIGR01351 862259002009 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 862259002010 AMP-binding site [chemical binding]; other site 862259002011 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 862259002012 preprotein translocase, SecY subunit; Region: 3a0501s007; TIGR00967 862259002013 SecY translocase; Region: SecY; pfam00344 862259002014 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 862259002015 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 862259002016 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 862259002017 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 862259002018 5S rRNA interface [nucleotide binding]; other site 862259002019 L27 interface [polypeptide binding]; other site 862259002020 23S rRNA interface [nucleotide binding]; other site 862259002021 L5 interface [polypeptide binding]; other site 862259002022 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 862259002023 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 862259002024 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 862259002025 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 862259002026 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 862259002027 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 862259002028 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 862259002029 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 862259002030 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 862259002031 KOW motif; Region: KOW; cl00354 862259002032 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 862259002033 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 862259002034 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943 862259002035 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 862259002036 23S rRNA interface [nucleotide binding]; other site 862259002037 5S rRNA interface [nucleotide binding]; other site 862259002038 putative antibiotic binding site [chemical binding]; other site 862259002039 L25 interface [polypeptide binding]; other site 862259002040 L27 interface [polypeptide binding]; other site 862259002041 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 862259002042 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 862259002043 G-X-X-G motif; other site 862259002044 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 862259002045 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 862259002046 putative translocon binding site; other site 862259002047 protein-rRNA interface [nucleotide binding]; other site 862259002048 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 862259002049 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 862259002050 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 862259002051 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 862259002052 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 862259002053 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 862259002054 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 862259002055 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 862259002056 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 862259002057 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 862259002058 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 862259002059 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 862259002060 Ca binding site [ion binding]; other site 862259002061 active site 862259002062 catalytic site [active] 862259002063 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 862259002064 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 862259002065 active site turn [active] 862259002066 phosphorylation site [posttranslational modification] 862259002067 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259002068 Transcriptional regulators [Transcription]; Region: PurR; COG1609 862259002069 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862259002070 DNA binding site [nucleotide binding] 862259002071 domain linker motif; other site 862259002072 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259002073 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862259002074 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 862259002075 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 862259002076 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 862259002077 homodimer interface [polypeptide binding]; other site 862259002078 NADP binding site [chemical binding]; other site 862259002079 substrate binding site [chemical binding]; other site 862259002080 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 862259002081 Cation transport protein; Region: TrkH; cl10514 862259002082 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 862259002083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259002084 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 862259002085 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 862259002086 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 862259002087 GatB domain; Region: GatB_Yqey; cl11497 862259002088 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 862259002089 Amidase; Region: Amidase; cl11426 862259002090 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 862259002091 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 862259002092 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 862259002093 nucleotide binding pocket [chemical binding]; other site 862259002094 K-X-D-G motif; other site 862259002095 catalytic site [active] 862259002096 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 862259002097 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 862259002098 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 862259002099 Dimer interface [polypeptide binding]; other site 862259002100 BRCT sequence motif; other site 862259002101 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 862259002102 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 862259002103 active site 862259002104 CAAX protease self-immunity; Region: Abi; cl00558 862259002105 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 862259002106 dimerization domain swap beta strand [polypeptide binding]; other site 862259002107 regulatory protein interface [polypeptide binding]; other site 862259002108 active site 862259002109 regulatory phosphorylation site [posttranslational modification]; other site 862259002110 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 862259002111 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259002112 Family description; Region: UvrD_C_2; cl15862 862259002113 RDD family; Region: RDD; cl00746 862259002114 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 862259002115 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862259002116 active site 862259002117 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259002118 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 862259002119 SelR domain; Region: SelR; pfam01641 862259002120 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 862259002121 hypothetical protein; Provisional; Region: PRK06148 862259002122 Protein of unknown function DUF262; Region: DUF262; cl14890 862259002123 putative transposase OrfB; Reviewed; Region: PHA02517 862259002124 HTH-like domain; Region: HTH_21; pfam13276 862259002125 Integrase core domain; Region: rve; cl01316 862259002126 Integrase core domain; Region: rve_3; cl15866 862259002127 Protein of unknown function DUF262; Region: DUF262; cl14890 862259002128 Protein of unknown function DUF262; Region: DUF262; cl14890 862259002129 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862259002130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862259002131 dimer interface [polypeptide binding]; other site 862259002132 conserved gate region; other site 862259002133 putative PBP binding loops; other site 862259002134 ABC-ATPase subunit interface; other site 862259002135 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 862259002136 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 862259002137 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259002138 Walker A/P-loop; other site 862259002139 ATP binding site [chemical binding]; other site 862259002140 Q-loop/lid; other site 862259002141 ABC transporter signature motif; other site 862259002142 Walker B; other site 862259002143 D-loop; other site 862259002144 H-loop/switch region; other site 862259002145 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 862259002146 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 862259002147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862259002148 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 862259002149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862259002150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862259002151 homodimer interface [polypeptide binding]; other site 862259002152 catalytic residue [active] 862259002153 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 862259002154 homotrimer interaction site [polypeptide binding]; other site 862259002155 putative active site [active] 862259002156 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259002157 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259002158 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259002159 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259002160 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259002161 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259002162 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259002163 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862259002164 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 862259002165 active site 862259002166 trimer interface [polypeptide binding]; other site 862259002167 allosteric site; other site 862259002168 active site lid [active] 862259002169 hexamer (dimer of trimers) interface [polypeptide binding]; other site 862259002170 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 862259002171 substrate binding site [chemical binding]; other site 862259002172 dimer interface [polypeptide binding]; other site 862259002173 catalytic triad [active] 862259002174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862259002175 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 862259002176 active site 862259002177 motif I; other site 862259002178 motif II; other site 862259002179 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862259002180 Sulfatase; Region: Sulfatase; cl10460 862259002181 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 862259002182 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 862259002183 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 862259002184 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 862259002185 intersubunit interface [polypeptide binding]; other site 862259002186 active site 862259002187 catalytic residue [active] 862259002188 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 862259002189 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 862259002190 active site 862259002191 substrate binding site [chemical binding]; other site 862259002192 metal binding site [ion binding]; metal-binding site 862259002193 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 862259002194 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 862259002195 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 862259002196 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 862259002197 Helix-turn-helix domains; Region: HTH; cl00088 862259002198 Helix-turn-helix domains; Region: HTH; cl00088 862259002199 HTH-like domain; Region: HTH_21; pfam13276 862259002200 Integrase core domain; Region: rve; cl01316 862259002201 Integrase core domain; Region: rve_3; cl15866 862259002202 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 862259002203 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 862259002204 active site 862259002205 phosphorylation site [posttranslational modification] 862259002206 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 862259002207 P-loop; other site 862259002208 active site 862259002209 phosphorylation site [posttranslational modification] 862259002210 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259002211 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 862259002212 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 862259002213 putative substrate binding site [chemical binding]; other site 862259002214 putative ATP binding site [chemical binding]; other site 862259002215 Helix-turn-helix domains; Region: HTH; cl00088 862259002216 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 862259002217 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 862259002218 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 862259002219 Helix-turn-helix domains; Region: HTH; cl00088 862259002220 Helix-turn-helix domains; Region: HTH; cl00088 862259002221 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 862259002222 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 862259002223 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259002224 V-type ATP synthase subunit I; Validated; Region: PRK05771 862259002225 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259002226 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259002227 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259002228 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259002229 V-type ATP synthase subunit I; Validated; Region: PRK05771 862259002230 Fic/DOC family; Region: Fic; cl00960 862259002231 RelB antitoxin; Region: RelB; cl01171 862259002232 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 862259002233 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 862259002234 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 862259002235 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 862259002236 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 862259002237 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 862259002238 active site 862259002239 phosphorylation site [posttranslational modification] 862259002240 alpha-mannosidase; Provisional; Region: PRK09819 862259002241 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 862259002242 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 862259002243 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 862259002244 P-loop; other site 862259002245 active site 862259002246 phosphorylation site [posttranslational modification] 862259002247 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259002248 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862259002249 active site 862259002250 adenylosuccinate lyase; Provisional; Region: PRK07492 862259002251 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 862259002252 tetramer interface [polypeptide binding]; other site 862259002253 active site 862259002254 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 862259002255 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 862259002256 GDP-binding site [chemical binding]; other site 862259002257 ACT binding site; other site 862259002258 IMP binding site; other site 862259002259 Helix-turn-helix domains; Region: HTH; cl00088 862259002260 Helix-turn-helix domains; Region: HTH; cl00088 862259002261 HTH-like domain; Region: HTH_21; pfam13276 862259002262 Integrase core domain; Region: rve; cl01316 862259002263 Integrase core domain; Region: rve_3; cl15866 862259002264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259002265 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259002266 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259002267 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 862259002268 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 862259002269 Class I ribonucleotide reductase; Region: RNR_I; cd01679 862259002270 active site 862259002271 dimer interface [polypeptide binding]; other site 862259002272 catalytic residues [active] 862259002273 effector binding site; other site 862259002274 R2 peptide binding site; other site 862259002275 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 862259002276 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 862259002277 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 862259002278 dimer interface [polypeptide binding]; other site 862259002279 putative radical transfer pathway; other site 862259002280 diiron center [ion binding]; other site 862259002281 tyrosyl radical; other site 862259002282 ribonuclease R; Region: RNase_R; TIGR02063 862259002283 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 862259002284 RNB domain; Region: RNB; pfam00773 862259002285 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 862259002286 RNA binding site [nucleotide binding]; other site 862259002287 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 862259002288 SmpB-tmRNA interface; other site 862259002289 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 862259002290 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259002291 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 862259002292 active site turn [active] 862259002293 phosphorylation site [posttranslational modification] 862259002294 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 862259002295 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 862259002296 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 862259002297 ornithine carbamoyltransferase; Validated; Region: PRK02102 862259002298 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 862259002299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259002300 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 862259002301 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 862259002302 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862259002303 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 862259002304 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862259002305 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 862259002306 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 862259002307 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 862259002308 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 862259002309 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 862259002310 alpha subunit interaction interface [polypeptide binding]; other site 862259002311 Walker A motif; other site 862259002312 ATP binding site [chemical binding]; other site 862259002313 Walker B motif; other site 862259002314 inhibitor binding site; inhibition site 862259002315 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 862259002316 ATP synthase; Region: ATP-synt; cl00365 862259002317 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 862259002318 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 862259002319 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 862259002320 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 862259002321 beta subunit interaction interface [polypeptide binding]; other site 862259002322 Walker A motif; other site 862259002323 ATP binding site [chemical binding]; other site 862259002324 Walker B motif; other site 862259002325 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 862259002326 Plant ATP synthase F0; Region: YMF19; cl07975 862259002327 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 862259002328 Plant ATP synthase F0; Region: YMF19; cl07975 862259002329 ATP synthase subunit C; Region: ATP-synt_C; cl00466 862259002330 ATP synthase A chain; Region: ATP-synt_A; cl00413 862259002331 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862259002332 active site 862259002333 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 862259002334 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 862259002335 dimer interface [polypeptide binding]; other site 862259002336 glycine-pyridoxal phosphate binding site [chemical binding]; other site 862259002337 active site 862259002338 folate binding site [chemical binding]; other site 862259002339 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 862259002340 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862259002341 active site residue [active] 862259002342 Putative peptidase (DUF31); Region: DUF31; pfam01732 862259002343 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 862259002344 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 862259002345 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 862259002346 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 862259002347 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 862259002348 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 862259002349 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 862259002350 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 862259002351 G-loop; other site 862259002352 DNA binding site [nucleotide binding] 862259002353 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 862259002354 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 862259002355 RPB1 interaction site [polypeptide binding]; other site 862259002356 RPB10 interaction site [polypeptide binding]; other site 862259002357 RPB11 interaction site [polypeptide binding]; other site 862259002358 RPB3 interaction site [polypeptide binding]; other site 862259002359 RPB12 interaction site [polypeptide binding]; other site 862259002360 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 862259002361 L11 interface [polypeptide binding]; other site 862259002362 putative EF-Tu interaction site [polypeptide binding]; other site 862259002363 putative EF-G interaction site [polypeptide binding]; other site 862259002364 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 862259002365 23S rRNA interface [nucleotide binding]; other site 862259002366 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 862259002367 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 862259002368 mRNA/rRNA interface [nucleotide binding]; other site 862259002369 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 862259002370 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 862259002371 23S rRNA interface [nucleotide binding]; other site 862259002372 L7/L12 interface [polypeptide binding]; other site 862259002373 putative thiostrepton binding site; other site 862259002374 L25 interface [polypeptide binding]; other site 862259002375 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 862259002376 active site 862259002377 tetramer interface; other site 862259002378 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862259002379 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 862259002380 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 862259002381 DXD motif; other site 862259002382 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 862259002383 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 862259002384 NAD binding site [chemical binding]; other site 862259002385 homodimer interface [polypeptide binding]; other site 862259002386 active site 862259002387 substrate binding site [chemical binding]; other site 862259002388 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 862259002389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259002390 UDP-galactopyranose mutase; Region: GLF; pfam03275 862259002391 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259002392 AAA domain; Region: AAA_21; pfam13304 862259002393 Walker A/P-loop; other site 862259002394 ATP binding site [chemical binding]; other site 862259002395 Q-loop/lid; other site 862259002396 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862259002397 ABC transporter signature motif; other site 862259002398 Walker B; other site 862259002399 D-loop; other site 862259002400 H-loop/switch region; other site 862259002401 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862259002402 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 862259002403 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 862259002404 Walker A/P-loop; other site 862259002405 ATP binding site [chemical binding]; other site 862259002406 Q-loop/lid; other site 862259002407 ABC transporter signature motif; other site 862259002408 Walker B; other site 862259002409 D-loop; other site 862259002410 H-loop/switch region; other site 862259002411 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862259002412 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 862259002413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862259002414 dimer interface [polypeptide binding]; other site 862259002415 conserved gate region; other site 862259002416 putative PBP binding loops; other site 862259002417 ABC-ATPase subunit interface; other site 862259002418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862259002419 dimer interface [polypeptide binding]; other site 862259002420 conserved gate region; other site 862259002421 putative PBP binding loops; other site 862259002422 ABC-ATPase subunit interface; other site 862259002423 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 862259002424 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 862259002425 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 862259002426 putative homodimer interface [polypeptide binding]; other site 862259002427 KOW motif; Region: KOW; cl00354 862259002428 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 862259002429 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 862259002430 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 862259002431 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 862259002432 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 862259002433 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 862259002434 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862259002435 active site 862259002436 HIGH motif; other site 862259002437 nucleotide binding site [chemical binding]; other site 862259002438 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862259002439 active site 862259002440 KMSKS motif; other site 862259002441 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 862259002442 hypothetical protein; Provisional; Region: PRK09609 862259002443 hypothetical protein; Provisional; Region: PRK09609 862259002444 replicative DNA helicase; Region: DnaB; TIGR00665 862259002445 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 862259002446 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 862259002447 Walker A motif; other site 862259002448 ATP binding site [chemical binding]; other site 862259002449 Walker B motif; other site 862259002450 DNA binding loops [nucleotide binding] 862259002451 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 862259002452 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 862259002453 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 862259002454 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 862259002455 putative active site [active] 862259002456 catalytic residue [active] 862259002457 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 862259002458 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 862259002459 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862259002460 active site 862259002461 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 862259002462 active site 862259002463 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 862259002464 excinuclease ABC subunit B; Provisional; Region: PRK05298 862259002465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862259002466 ATP binding site [chemical binding]; other site 862259002467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862259002468 nucleotide binding region [chemical binding]; other site 862259002469 ATP-binding site [chemical binding]; other site 862259002470 Ultra-violet resistance protein B; Region: UvrB; pfam12344 862259002471 UvrB/uvrC motif; Region: UVR; pfam02151 862259002472 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 862259002473 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 862259002474 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 862259002475 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 862259002476 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 862259002477 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 862259002478 HPr kinase/phosphorylase; Provisional; Region: PRK05428 862259002479 DRTGG domain; Region: DRTGG; cl12147 862259002480 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 862259002481 Hpr binding site; other site 862259002482 active site 862259002483 homohexamer subunit interaction site [polypeptide binding]; other site 862259002484 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 862259002485 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 862259002486 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 862259002487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259002488 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862259002489 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 862259002490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 862259002491 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 862259002492 putative transposase OrfB; Reviewed; Region: PHA02517 862259002493 HTH-like domain; Region: HTH_21; pfam13276 862259002494 Integrase core domain; Region: rve; cl01316 862259002495 Integrase core domain; Region: rve_3; cl15866 862259002496 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259002497 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259002498 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 862259002499 active site 862259002500 catalytic residues [active] 862259002501 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 862259002502 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259002503 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 862259002504 active site turn [active] 862259002505 phosphorylation site [posttranslational modification] 862259002506 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 862259002507 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 862259002508 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 862259002509 active site turn [active] 862259002510 phosphorylation site [posttranslational modification] 862259002511 Divergent AAA domain; Region: AAA_4; pfam04326 862259002512 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 862259002513 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 862259002514 DNA topoisomerase I; Validated; Region: PRK05582 862259002515 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 862259002516 active site 862259002517 metal binding site [ion binding]; metal-binding site 862259002518 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 862259002519 domain I; other site 862259002520 DNA binding groove [nucleotide binding] 862259002521 phosphate binding site [ion binding]; other site 862259002522 domain II; other site 862259002523 domain III; other site 862259002524 nucleotide binding site [chemical binding]; other site 862259002525 catalytic site [active] 862259002526 domain IV; other site 862259002527 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 862259002528 Integrase core domain; Region: rve; cl01316 862259002529 Integrase core domain; Region: rve_3; cl15866 862259002530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 862259002531 Helix-turn-helix domains; Region: HTH; cl00088 862259002532 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 862259002533 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 862259002534 Walker A/P-loop; other site 862259002535 ATP binding site [chemical binding]; other site 862259002536 Q-loop/lid; other site 862259002537 ABC transporter signature motif; other site 862259002538 Walker B; other site 862259002539 D-loop; other site 862259002540 H-loop/switch region; other site 862259002541 cytochrome b; Provisional; Region: CYTB; MTH00100 862259002542 ABC-2 type transporter; Region: ABC2_membrane; cl11417 862259002543 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 862259002544 Protein of unknown function DUF45; Region: DUF45; cl00636 862259002545 GTP-binding protein YchF; Reviewed; Region: PRK09601 862259002546 YchF GTPase; Region: YchF; cd01900 862259002547 G1 box; other site 862259002548 GTP/Mg2+ binding site [chemical binding]; other site 862259002549 Switch I region; other site 862259002550 G2 box; other site 862259002551 Switch II region; other site 862259002552 G3 box; other site 862259002553 G4 box; other site 862259002554 G5 box; other site 862259002555 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 862259002556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 862259002557 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 862259002558 Amino acid permease; Region: AA_permease_2; pfam13520 862259002559 Amino acid permease; Region: AA_permease_2; pfam13520 862259002560 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 862259002561 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862259002562 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862259002563 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 862259002564 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 862259002565 IHF dimer interface [polypeptide binding]; other site 862259002566 IHF - DNA interface [nucleotide binding]; other site 862259002567 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 862259002568 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 862259002569 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 862259002570 motif 1; other site 862259002571 dimer interface [polypeptide binding]; other site 862259002572 active site 862259002573 motif 2; other site 862259002574 motif 3; other site 862259002575 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 862259002576 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 862259002577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862259002578 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 862259002579 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 862259002580 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 862259002581 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862259002582 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 862259002583 catalytic triad [active] 862259002584 conserved cis-peptide bond; other site 862259002585 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 862259002586 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259002587 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 862259002588 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 862259002589 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 862259002590 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259002591 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259002592 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 862259002593 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259002594 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 862259002595 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259002596 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 862259002597 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259002598 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259002599 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259002600 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 862259002601 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 862259002602 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862259002603 putative transposase OrfB; Reviewed; Region: PHA02517 862259002604 HTH-like domain; Region: HTH_21; pfam13276 862259002605 Integrase core domain; Region: rve; cl01316 862259002606 Integrase core domain; Region: rve_3; cl15866 862259002607 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862259002608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862259002609 Walker A motif; other site 862259002610 ATP binding site [chemical binding]; other site 862259002611 Walker B motif; other site 862259002612 arginine finger; other site 862259002613 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 862259002614 active site 862259002615 catalytic triad [active] 862259002616 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862259002617 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862259002618 putative transposase OrfB; Reviewed; Region: PHA02517 862259002619 HTH-like domain; Region: HTH_21; pfam13276 862259002620 Integrase core domain; Region: rve; cl01316 862259002621 Integrase core domain; Region: rve_3; cl15866 862259002622 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862259002623 active site 862259002624 ATP binding site [chemical binding]; other site 862259002625 substrate binding site [chemical binding]; other site 862259002626 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 862259002627 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862259002628 active site 862259002629 motif I; other site 862259002630 motif II; other site 862259002631 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 862259002632 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 862259002633 Ribonuclease P; Region: Ribonuclease_P; cl00457 862259002634 Ribosomal protein L34; Region: Ribosomal_L34; cl00370