-- dump date 20120504_153510 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272635000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 272635000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272635000003 Walker A motif; other site 272635000004 ATP binding site [chemical binding]; other site 272635000005 Walker B motif; other site 272635000006 arginine finger; other site 272635000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272635000008 DnaA box-binding interface [nucleotide binding]; other site 272635000009 DNA polymerase sliding clamp subunit (PCNA homolog) [DNA replication, recombination, and repair]; Region: DnaN; COG0592 272635000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272635000011 putative DNA binding surface [nucleotide binding]; other site 272635000012 dimer interface [polypeptide binding]; other site 272635000013 beta-clamp/clamp loader binding surface; other site 272635000014 beta-clamp/translesion DNA polymerase binding surface; other site 272635000015 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 272635000016 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272635000017 LicD family; Region: LicD; cl01378 272635000018 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272635000019 nucleotide binding site/active site [active] 272635000020 HIT family signature motif; other site 272635000021 catalytic residue [active] 272635000022 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272635000023 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272635000024 23S rRNA interface [nucleotide binding]; other site 272635000025 L7/L12 interface [polypeptide binding]; other site 272635000026 putative thiostrepton binding site; other site 272635000027 L25 interface [polypeptide binding]; other site 272635000028 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272635000029 mRNA/rRNA interface [nucleotide binding]; other site 272635000030 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635000031 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635000032 PQ loop repeat; Region: PQ-loop; cl12056 272635000033 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272635000034 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272635000035 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272635000036 G1 box; other site 272635000037 GTP/Mg2+ binding site [chemical binding]; other site 272635000038 Switch I region; other site 272635000039 G2 box; other site 272635000040 Switch II region; other site 272635000041 G3 box; other site 272635000042 G5 box; other site 272635000043 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272635000044 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272635000045 active site 272635000046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635000047 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 272635000048 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272635000049 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272635000050 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272635000051 active site turn [active] 272635000052 phosphorylation site [posttranslational modification] 272635000053 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 272635000054 HPr interaction site; other site 272635000055 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272635000056 active site 272635000057 phosphorylation site [posttranslational modification] 272635000058 putative transposase OrfB; Reviewed; Region: PHA02517 272635000059 Integrase core domain; Region: rve; cl01316 272635000060 hypothetical protein; Provisional; Region: PRK06148 272635000061 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 272635000062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635000063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635000064 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272635000065 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272635000066 DHH family; Region: DHH; pfam01368 272635000067 DHHA1 domain; Region: DHHA1; pfam02272 272635000068 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 272635000069 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272635000070 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272635000071 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 272635000072 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 272635000073 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 272635000074 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 272635000075 Catalytic site; other site 272635000076 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 272635000077 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000078 Walker A/P-loop; other site 272635000079 ATP binding site [chemical binding]; other site 272635000080 Q-loop/lid; other site 272635000081 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000082 ABC transporter signature motif; other site 272635000083 Walker B; other site 272635000084 D-loop; other site 272635000085 H-loop/switch region; other site 272635000086 TOBE domain; Region: TOBE_2; cl01440 272635000087 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272635000088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272635000089 dimer interface [polypeptide binding]; other site 272635000090 conserved gate region; other site 272635000091 putative PBP binding loops; other site 272635000092 ABC-ATPase subunit interface; other site 272635000093 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272635000094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272635000095 dimer interface [polypeptide binding]; other site 272635000096 conserved gate region; other site 272635000097 putative PBP binding loops; other site 272635000098 ABC-ATPase subunit interface; other site 272635000099 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 272635000100 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 272635000101 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 272635000102 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272635000103 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272635000104 seryl-tRNA synthetase; Provisional; Region: PRK05431 272635000105 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272635000106 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 272635000107 motif 1; other site 272635000108 dimer interface [polypeptide binding]; other site 272635000109 active site 272635000110 motif 2; other site 272635000111 motif 3; other site 272635000112 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272635000113 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272635000114 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272635000115 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272635000116 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272635000117 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272635000118 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272635000119 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272635000120 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272635000121 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272635000122 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 272635000123 Walker A/P-loop; other site 272635000124 ATP binding site [chemical binding]; other site 272635000125 Q-loop/lid; other site 272635000126 ABC transporter signature motif; other site 272635000127 Walker B; other site 272635000128 D-loop; other site 272635000129 H-loop/switch region; other site 272635000130 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 272635000131 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 272635000132 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272635000133 Walker A/P-loop; other site 272635000134 ATP binding site [chemical binding]; other site 272635000135 Q-loop/lid; other site 272635000136 ABC transporter signature motif; other site 272635000137 Walker B; other site 272635000138 D-loop; other site 272635000139 H-loop/switch region; other site 272635000140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635000141 DNA binding site [nucleotide binding] 272635000142 substrate interaction site [chemical binding]; other site 272635000143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635000144 cofactor binding site; other site 272635000145 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 272635000146 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272635000147 putative active site [active] 272635000148 substrate binding site [chemical binding]; other site 272635000149 putative cosubstrate binding site; other site 272635000150 catalytic site [active] 272635000151 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272635000152 substrate binding site [chemical binding]; other site 272635000153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635000154 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 272635000155 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 272635000156 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 272635000157 Predicted integral membrane protein [Function unknown]; Region: COG5522; cl02331 272635000158 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07133 272635000159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272635000160 Walker A motif; other site 272635000161 ATP binding site [chemical binding]; other site 272635000162 Walker B motif; other site 272635000163 arginine finger; other site 272635000164 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07133 272635000165 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 272635000166 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 272635000167 RecR protein; Region: RecR; pfam02132 272635000168 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272635000169 putative active site [active] 272635000170 putative metal-binding site [ion binding]; other site 272635000171 tetramer interface [polypeptide binding]; other site 272635000172 thymidylate kinase; Validated; Region: tmk; PRK00698 272635000173 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272635000174 TMP-binding site; other site 272635000175 ATP-binding site [chemical binding]; other site 272635000176 DNA polymerase III subunit delta'; Validated; Region: PRK07132 272635000177 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000178 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 272635000179 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 272635000180 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272635000181 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 272635000182 putative active site [active] 272635000183 putative metal binding site [ion binding]; other site 272635000184 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272635000185 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000186 Walker A/P-loop; other site 272635000187 ATP binding site [chemical binding]; other site 272635000188 ABC transporter; Region: ABC_tran; pfam00005 272635000189 Q-loop/lid; other site 272635000190 ABC transporter signature motif; other site 272635000191 Walker B; other site 272635000192 D-loop; other site 272635000193 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000194 H-loop/switch region; other site 272635000195 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272635000196 FtsX-like permease family; Region: FtsX; pfam02687 272635000197 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000198 Walker A/P-loop; other site 272635000199 ATP binding site [chemical binding]; other site 272635000200 Q-loop/lid; other site 272635000201 ABC transporter signature motif; other site 272635000202 Walker B; other site 272635000203 D-loop; other site 272635000204 H-loop/switch region; other site 272635000205 FtsX-like permease family; Region: FtsX; pfam02687 272635000206 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272635000207 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 272635000208 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272635000209 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272635000210 ATP binding site [chemical binding]; other site 272635000211 Mg++ binding site [ion binding]; other site 272635000212 motif III; other site 272635000213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272635000214 nucleotide binding region [chemical binding]; other site 272635000215 ATP-binding site [chemical binding]; other site 272635000216 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl01740 272635000217 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 272635000218 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000219 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 272635000220 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000221 HsdM N-terminal domain; Region: HsdM_N; pfam12161 272635000222 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 272635000223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635000224 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272635000225 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272635000226 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272635000227 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 272635000228 Recombination protein U; Region: RecU; cl01314 272635000229 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272635000230 IHF - DNA interface [nucleotide binding]; other site 272635000231 IHF dimer interface [polypeptide binding]; other site 272635000232 GTP-binding protein Der; Reviewed; Region: PRK00093 272635000233 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272635000234 G1 box; other site 272635000235 GTP/Mg2+ binding site [chemical binding]; other site 272635000236 Switch I region; other site 272635000237 G2 box; other site 272635000238 Switch II region; other site 272635000239 G3 box; other site 272635000240 G4 box; other site 272635000241 G5 box; other site 272635000242 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272635000243 G1 box; other site 272635000244 GTP/Mg2+ binding site [chemical binding]; other site 272635000245 Switch I region; other site 272635000246 G2 box; other site 272635000247 G3 box; other site 272635000248 Switch II region; other site 272635000249 G4 box; other site 272635000250 G5 box; other site 272635000251 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 272635000252 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272635000253 CMP-binding site; other site 272635000254 The sites determining sugar specificity; other site 272635000255 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272635000256 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272635000257 HIGH motif; other site 272635000258 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272635000259 active site 272635000260 KMSKS motif; other site 272635000261 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272635000262 tRNA binding surface [nucleotide binding]; other site 272635000263 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 272635000264 putative dimer interface [polypeptide binding]; other site 272635000265 catalytic triad [active] 272635000266 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272635000267 endonuclease III; Region: ENDO3c; smart00478 272635000268 minor groove reading motif; other site 272635000269 helix-hairpin-helix signature motif; other site 272635000270 substrate binding pocket [chemical binding]; other site 272635000271 active site 272635000272 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 272635000273 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272635000274 DNA binding site [nucleotide binding] 272635000275 active site 272635000276 excinuclease ABC subunit B; Provisional; Region: PRK05298 272635000277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272635000278 ATP binding site [chemical binding]; other site 272635000279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272635000280 nucleotide binding region [chemical binding]; other site 272635000281 ATP-binding site [chemical binding]; other site 272635000282 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272635000283 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964 272635000284 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272635000285 active site 272635000286 nucleotide binding site [chemical binding]; other site 272635000287 HIGH motif; other site 272635000288 KMSKS motif; other site 272635000289 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272635000290 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000291 Walker A/P-loop; other site 272635000292 ATP binding site [chemical binding]; other site 272635000293 Q-loop/lid; other site 272635000294 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272635000295 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000296 ABC transporter signature motif; other site 272635000297 Walker B; other site 272635000298 D-loop; other site 272635000299 H-loop/switch region; other site 272635000300 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272635000301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272635000302 dimer interface [polypeptide binding]; other site 272635000303 conserved gate region; other site 272635000304 putative PBP binding loops; other site 272635000305 ABC-ATPase subunit interface; other site 272635000306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272635000307 dimer interface [polypeptide binding]; other site 272635000308 conserved gate region; other site 272635000309 putative PBP binding loops; other site 272635000310 ABC-ATPase subunit interface; other site 272635000311 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272635000312 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272635000313 Ca binding site [ion binding]; other site 272635000314 active site 272635000315 catalytic site [active] 272635000316 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 272635000317 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 272635000318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272635000319 nucleotide binding region [chemical binding]; other site 272635000320 ATP-binding site [chemical binding]; other site 272635000321 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272635000322 RF-1 domain; Region: RF-1; cl02875 272635000323 RF-1 domain; Region: RF-1; cl02875 272635000324 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 272635000325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635000326 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000327 Walker A/P-loop; other site 272635000328 ATP binding site [chemical binding]; other site 272635000329 ABC transporter; Region: ABC_tran; pfam00005 272635000330 Q-loop/lid; other site 272635000331 ABC transporter signature motif; other site 272635000332 Walker B; other site 272635000333 D-loop; other site 272635000334 H-loop/switch region; other site 272635000335 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 272635000336 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 272635000337 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272635000338 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272635000339 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272635000340 hypothetical protein; Provisional; Region: PRK08185 272635000341 intersubunit interface [polypeptide binding]; other site 272635000342 active site 272635000343 zinc binding site [ion binding]; other site 272635000344 Na+ binding site [ion binding]; other site 272635000345 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 272635000346 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 272635000347 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272635000348 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272635000349 putative acyl-acceptor binding pocket; other site 272635000350 ScpA/B protein; Region: ScpA_ScpB; cl00598 272635000351 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 272635000352 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272635000353 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 272635000354 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 272635000355 active site 272635000356 UGMP family protein; Validated; Region: PRK09604 272635000357 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 272635000358 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 272635000359 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 272635000360 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 272635000361 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 272635000362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635000363 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272635000364 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272635000365 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272635000366 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272635000367 active site 272635000368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 272635000369 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 272635000370 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272635000371 active site 272635000372 phosphorylation site [posttranslational modification] 272635000373 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272635000374 P-loop; other site 272635000375 active site 272635000376 phosphorylation site [posttranslational modification] 272635000377 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272635000378 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272635000379 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 272635000380 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272635000381 active site 272635000382 dimer interface [polypeptide binding]; other site 272635000383 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272635000384 dimer interface [polypeptide binding]; other site 272635000385 active site 272635000386 Divergent AAA domain; Region: AAA_4; pfam04326 272635000387 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635000388 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635000389 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635000390 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272635000391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635000392 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 272635000393 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272635000394 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272635000395 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 272635000396 Catalytic site; other site 272635000397 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 272635000398 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 272635000399 HrcA protein C terminal domain; Region: HrcA; pfam01628 272635000400 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 272635000401 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272635000402 dimer interface [polypeptide binding]; other site 272635000403 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272635000404 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 272635000405 Cation transport protein; Region: TrkH; cl10514 272635000406 thymidine kinase; Provisional; Region: PRK04296 272635000407 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 272635000408 DNA gyrase subunit A; Validated; Region: PRK05560 272635000409 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 272635000410 CAP-like domain; other site 272635000411 active site 272635000412 primary dimer interface [polypeptide binding]; other site 272635000413 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272635000414 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272635000415 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272635000416 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272635000417 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272635000418 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 272635000419 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 272635000420 Ribonuclease P; Region: Ribonuclease_P; cl00457 272635000421 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 272635000422 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 272635000423 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 272635000424 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272635000425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272635000426 motif II; other site 272635000427 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272635000428 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 272635000429 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272635000430 GIY-YIG motif/motif A; other site 272635000431 active site 272635000432 catalytic site [active] 272635000433 putative DNA binding site [nucleotide binding]; other site 272635000434 metal binding site [ion binding]; metal-binding site 272635000435 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272635000436 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 272635000437 dimerization interface [polypeptide binding]; other site 272635000438 DPS ferroxidase diiron center [ion binding]; other site 272635000439 ion pore; other site 272635000440 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 272635000441 Recombination protein O N terminal; Region: RecO_N; cl15812 272635000442 Recombination protein O C terminal; Region: RecO_C; pfam02565 272635000443 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 272635000444 DAK2 domain; Region: Dak2; cl03685 272635000445 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 272635000446 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 272635000447 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272635000448 dimerization interface [polypeptide binding]; other site 272635000449 active site 272635000450 metal binding site [ion binding]; metal-binding site 272635000451 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272635000452 dsRNA binding site [nucleotide binding]; other site 272635000453 GTP-binding protein YchF; Reviewed; Region: PRK09601 272635000454 YchF GTPase; Region: YchF; cd01900 272635000455 G1 box; other site 272635000456 GTP/Mg2+ binding site [chemical binding]; other site 272635000457 Switch I region; other site 272635000458 G2 box; other site 272635000459 Switch II region; other site 272635000460 G3 box; other site 272635000461 G4 box; other site 272635000462 G5 box; other site 272635000463 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272635000464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272635000465 S-adenosylmethionine binding site [chemical binding]; other site 272635000466 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272635000467 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 272635000468 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 272635000469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635000470 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272635000471 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272635000472 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272635000473 catalytic residue [active] 272635000474 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272635000475 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272635000476 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272635000477 catalytic residue [active] 272635000478 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272635000479 trimerization site [polypeptide binding]; other site 272635000480 active site 272635000481 Protein of unknown function (DUF402); Region: DUF402; cl00979 272635000482 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 272635000483 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272635000484 active site 272635000485 HIGH motif; other site 272635000486 nucleotide binding site [chemical binding]; other site 272635000487 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272635000488 active site 272635000489 KMSKS motif; other site 272635000490 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 272635000491 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 272635000492 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 272635000493 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272635000494 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 272635000495 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 272635000496 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272635000497 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272635000498 putative homodimer interface [polypeptide binding]; other site 272635000499 prolyl-tRNA synthetase; Provisional; Region: PRK08661 272635000500 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 272635000501 dimer interface [polypeptide binding]; other site 272635000502 motif 1; other site 272635000503 active site 272635000504 motif 2; other site 272635000505 motif 3; other site 272635000506 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 272635000507 anticodon binding site; other site 272635000508 zinc-binding site [ion binding]; other site 272635000509 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272635000510 catalytic residues [active] 272635000511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 272635000512 cofactor binding site; other site 272635000513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 272635000514 DNA binding site [nucleotide binding] 272635000515 substrate interaction site [chemical binding]; other site 272635000516 Protein of unknown function DUF262; Region: DUF262; cl14890 272635000517 Protein of unknown function DUF262; Region: DUF262; cl14890 272635000518 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 272635000519 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272635000520 active site 272635000521 DNA binding site [nucleotide binding] 272635000522 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 272635000523 chaperone protein DnaJ; Provisional; Region: PRK14277 272635000524 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272635000525 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 272635000526 Walker A/P-loop; other site 272635000527 ATP binding site [chemical binding]; other site 272635000528 Q-loop/lid; other site 272635000529 ABC transporter signature motif; other site 272635000530 Walker B; other site 272635000531 D-loop; other site 272635000532 H-loop/switch region; other site 272635000533 ABC-2 type transporter; Region: ABC2_membrane; cl11417 272635000534 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 272635000535 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 272635000536 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 272635000537 P-loop; other site 272635000538 active site 272635000539 phosphorylation site [posttranslational modification] 272635000540 Amidase; Region: Amidase; cl11426 272635000541 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272635000542 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272635000543 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272635000544 GatB domain; Region: GatB_Yqey; cl11497 272635000545 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 272635000546 transcription termination factor NusA; Region: NusA; TIGR01953 272635000547 NusA N-terminal domain; Region: NusA_N; pfam08529 272635000548 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272635000549 G-X-X-G motif; other site 272635000550 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 272635000551 putative RNA binding cleft [nucleotide binding]; other site 272635000552 translation initiation factor IF-2; Region: IF-2; TIGR00487 272635000553 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272635000554 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272635000555 G1 box; other site 272635000556 putative GEF interaction site [polypeptide binding]; other site 272635000557 GTP/Mg2+ binding site [chemical binding]; other site 272635000558 Switch I region; other site 272635000559 G2 box; other site 272635000560 G3 box; other site 272635000561 Switch II region; other site 272635000562 G4 box; other site 272635000563 G5 box; other site 272635000564 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272635000565 Translation-initiation factor 2; Region: IF-2; pfam11987 272635000566 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272635000567 trigger factor; Provisional; Region: tig; PRK01490 272635000568 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 272635000569 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272635000570 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 272635000571 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635000572 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272635000573 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 272635000574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272635000575 dimer interface [polypeptide binding]; other site 272635000576 conserved gate region; other site 272635000577 putative PBP binding loops; other site 272635000578 ABC-ATPase subunit interface; other site 272635000579 ribosome recycling factor; Reviewed; Region: frr; PRK00083 272635000580 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cl00240 272635000581 hinge region; other site 272635000582 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272635000583 putative nucleotide binding site [chemical binding]; other site 272635000584 uridine monophosphate binding site [chemical binding]; other site 272635000585 homohexameric interface [polypeptide binding]; other site 272635000586 glycerol kinase; Provisional; Region: glpK; PRK00047 272635000587 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272635000588 N- and C-terminal domain interface [polypeptide binding]; other site 272635000589 active site 272635000590 MgATP binding site [chemical binding]; other site 272635000591 catalytic site [active] 272635000592 metal binding site [ion binding]; metal-binding site 272635000593 glycerol binding site [chemical binding]; other site 272635000594 homotetramer interface [polypeptide binding]; other site 272635000595 homodimer interface [polypeptide binding]; other site 272635000596 FBP binding site [chemical binding]; other site 272635000597 protein IIAGlc interface [polypeptide binding]; other site 272635000598 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 272635000599 amphipathic channel; other site 272635000600 Asn-Pro-Ala signature motifs; other site 272635000601 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272635000602 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 272635000603 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 272635000604 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000605 Walker A/P-loop; other site 272635000606 ATP binding site [chemical binding]; other site 272635000607 Q-loop/lid; other site 272635000608 ABC transporter signature motif; other site 272635000609 Walker B; other site 272635000610 D-loop; other site 272635000611 H-loop/switch region; other site 272635000612 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 272635000613 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 272635000614 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 272635000615 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272635000616 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 272635000617 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 272635000618 F0F1-type ATP synthase, alpha subunit [Energy production and conversion]; Region: AtpA; COG0056 272635000619 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000620 Walker A motif; other site 272635000621 ATP binding site [chemical binding]; other site 272635000622 Walker B motif; other site 272635000623 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272635000624 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000625 Walker A motif; other site 272635000626 ATP binding site [chemical binding]; other site 272635000627 Walker B motif; other site 272635000628 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272635000629 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 272635000630 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 272635000631 Acetokinase family; Region: Acetate_kinase; cl01029 272635000632 propionate/acetate kinase; Provisional; Region: PRK12379 272635000633 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 272635000634 G1 box; other site 272635000635 GTP/Mg2+ binding site [chemical binding]; other site 272635000636 Switch I region; other site 272635000637 G2 box; other site 272635000638 G3 box; other site 272635000639 Switch II region; other site 272635000640 G4 box; other site 272635000641 pyruvate kinase; Provisional; Region: PRK05826 272635000642 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 272635000643 domain interfaces; other site 272635000644 active site 272635000645 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 272635000646 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 272635000647 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 272635000648 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272635000649 active site 272635000650 HIGH motif; other site 272635000651 KMSK motif region; other site 272635000652 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272635000653 tRNA binding surface [nucleotide binding]; other site 272635000654 anticodon binding site; other site 272635000655 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272635000656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272635000657 active site 272635000658 motif I; other site 272635000659 motif II; other site 272635000660 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635000661 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 272635000662 Phosphoglycerate kinase; Region: PGK; pfam00162 272635000663 substrate binding site [chemical binding]; other site 272635000664 hinge regions; other site 272635000665 ADP binding site [chemical binding]; other site 272635000666 catalytic site [active] 272635000667 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 272635000668 GTP-binding protein LepA; Provisional; Region: PRK05433 272635000669 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 272635000670 G1 box; other site 272635000671 putative GEF interaction site [polypeptide binding]; other site 272635000672 GTP/Mg2+ binding site [chemical binding]; other site 272635000673 Switch I region; other site 272635000674 G2 box; other site 272635000675 G3 box; other site 272635000676 Switch II region; other site 272635000677 G4 box; other site 272635000678 G5 box; other site 272635000679 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272635000680 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272635000681 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272635000682 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635000683 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272635000684 protein RecA; Region: tigrfam_recA; TIGR02012 272635000685 hexamer interface [polypeptide binding]; other site 272635000686 Walker A motif; other site 272635000687 ATP binding site [chemical binding]; other site 272635000688 Walker B motif; other site 272635000689 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272635000690 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 272635000691 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 272635000692 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 272635000693 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 272635000694 hypothetical protein; Provisional; Region: PRK09609 272635000695 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 272635000696 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272635000697 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272635000698 active site 272635000699 HIGH motif; other site 272635000700 nucleotide binding site [chemical binding]; other site 272635000701 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272635000702 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272635000703 active site 272635000704 KMSKS motif; other site 272635000705 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272635000706 tRNA binding surface [nucleotide binding]; other site 272635000707 anticodon binding site; other site 272635000708 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 272635000709 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272635000710 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272635000711 homodimer interface [polypeptide binding]; other site 272635000712 NADP binding site [chemical binding]; other site 272635000713 substrate binding site [chemical binding]; other site 272635000714 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272635000715 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272635000716 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272635000717 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 272635000718 ribosomal protein L20; Region: rpl20; CHL00068 272635000719 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272635000720 23S rRNA binding site [nucleotide binding]; other site 272635000721 L21 binding site [polypeptide binding]; other site 272635000722 L13 binding site [polypeptide binding]; other site 272635000723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272635000724 putative substrate translocation pore; other site 272635000725 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 272635000726 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 272635000727 active site 272635000728 catalytic site [active] 272635000729 metal binding site [ion binding]; metal-binding site 272635000730 dimer interface [polypeptide binding]; other site 272635000731 FAD dependent oxidoreductase; Region: DAO; pfam01266 272635000732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635000733 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 272635000734 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 272635000735 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272635000736 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 272635000737 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272635000738 alpha subunit interaction interface [polypeptide binding]; other site 272635000739 Walker A motif; other site 272635000740 ATP binding site [chemical binding]; other site 272635000741 Walker B motif; other site 272635000742 inhibitor binding site; inhibition site 272635000743 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272635000744 ATP synthase; Region: ATP-synt; cl00365 272635000745 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 272635000746 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272635000747 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 272635000748 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272635000749 beta subunit interaction interface [polypeptide binding]; other site 272635000750 Walker A motif; other site 272635000751 ATP binding site [chemical binding]; other site 272635000752 Walker B motif; other site 272635000753 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272635000754 Plant ATP synthase F0; Region: YMF19; cl07975 272635000755 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 272635000756 ATP synthase subunit C; Region: ATP-synt_C; cl00466 272635000757 ATP synthase A chain; Region: ATP-synt_A; cl00413 272635000758 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 272635000759 Sulfatase; Region: Sulfatase; cl10460 272635000760 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 272635000761 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 272635000762 catalytic motif [active] 272635000763 Zn binding site [ion binding]; other site 272635000764 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 272635000765 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272635000766 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272635000767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272635000768 dimer interface [polypeptide binding]; other site 272635000769 conserved gate region; other site 272635000770 putative PBP binding loops; other site 272635000771 ABC-ATPase subunit interface; other site 272635000772 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272635000773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272635000774 dimer interface [polypeptide binding]; other site 272635000775 conserved gate region; other site 272635000776 putative PBP binding loops; other site 272635000777 ABC-ATPase subunit interface; other site 272635000778 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272635000779 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 272635000780 Walker A/P-loop; other site 272635000781 ATP binding site [chemical binding]; other site 272635000782 Q-loop/lid; other site 272635000783 ABC transporter signature motif; other site 272635000784 Walker B; other site 272635000785 D-loop; other site 272635000786 H-loop/switch region; other site 272635000787 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272635000788 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 272635000789 Walker A/P-loop; other site 272635000790 ATP binding site [chemical binding]; other site 272635000791 Q-loop/lid; other site 272635000792 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 272635000793 ABC transporter signature motif; other site 272635000794 Walker B; other site 272635000795 D-loop; other site 272635000796 H-loop/switch region; other site 272635000797 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272635000798 Putative peptidase (DUF31); Region: DUF31; pfam01732 272635000799 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272635000800 core dimer interface [polypeptide binding]; other site 272635000801 peripheral dimer interface [polypeptide binding]; other site 272635000802 L10 interface [polypeptide binding]; other site 272635000803 L11 interface [polypeptide binding]; other site 272635000804 putative EF-Tu interaction site [polypeptide binding]; other site 272635000805 putative EF-G interaction site [polypeptide binding]; other site 272635000806 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272635000807 23S rRNA interface [nucleotide binding]; other site 272635000808 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272635000809 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 272635000810 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272635000811 MatE; Region: MatE; cl10513 272635000812 Domain of unknown function (DUF205); Region: DUF205; cl00410 272635000813 Amino acid permease; Region: AA_permease; pfam00324 272635000814 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272635000815 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272635000816 RNA binding surface [nucleotide binding]; other site 272635000817 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 272635000818 active site 272635000819 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 272635000820 RNA/DNA hybrid binding site [nucleotide binding]; other site 272635000821 active site 272635000822 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272635000823 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272635000824 active site 272635000825 motif I; other site 272635000826 motif II; other site 272635000827 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272635000828 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 272635000829 active site 272635000830 metal binding site [ion binding]; metal-binding site 272635000831 homotetramer interface [polypeptide binding]; other site 272635000832 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 272635000833 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272635000834 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 272635000835 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 272635000836 DivIVA domain; Region: DivI1A_domain; TIGR03544 272635000837 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 272635000838 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The...; Region: YlqF; cd01856 272635000839 GTP/Mg2+ binding site [chemical binding]; other site 272635000840 G4 box; other site 272635000841 G5 box; other site 272635000842 G1 box; other site 272635000843 Switch I region; other site 272635000844 G2 box; other site 272635000845 G3 box; other site 272635000846 Switch II region; other site 272635000847 Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones]; Region: COG1281 272635000848 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 272635000849 dimerization interface [polypeptide binding]; other site 272635000850 domain crossover interface; other site 272635000851 redox-dependent activation switch; other site 272635000852 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635000853 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635000854 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635000855 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272635000856 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272635000857 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272635000858 DNA binding site [nucleotide binding] 272635000859 catalytic residue [active] 272635000860 H2TH interface [polypeptide binding]; other site 272635000861 putative catalytic residues [active] 272635000862 turnover-facilitating residue; other site 272635000863 intercalation triad [nucleotide binding]; other site 272635000864 8OG recognition residue [nucleotide binding]; other site 272635000865 putative reading head residues; other site 272635000866 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272635000867 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272635000868 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272635000869 active site 272635000870 catalytic triad [active] 272635000871 oxyanion hole [active] 272635000872 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272635000873 intersubunit interface [polypeptide binding]; other site 272635000874 active site 272635000875 catalytic residue [active] 272635000876 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 272635000877 oligoendopeptidase F; Region: pepF; TIGR00181 272635000878 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 272635000879 active site 272635000880 Zn binding site [ion binding]; other site 272635000881 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 272635000882 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 272635000883 Nuclease-related domain; Region: NERD; pfam08378 272635000884 Protein of unknown function DUF45; Region: DUF45; cl00636 272635000885 Competence-damaged protein; Region: CinA; cl00666 272635000886 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272635000887 16S/18S rRNA binding site [nucleotide binding]; other site 272635000888 S13e-L30e interaction site [polypeptide binding]; other site 272635000889 25S rRNA binding site [nucleotide binding]; other site 272635000890 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 272635000891 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 272635000892 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272635000893 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272635000894 dimer interface [polypeptide binding]; other site 272635000895 anticodon binding site; other site 272635000896 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 272635000897 homodimer interface [polypeptide binding]; other site 272635000898 motif 1; other site 272635000899 active site 272635000900 motif 2; other site 272635000901 GAD domain; Region: GAD; pfam02938 272635000902 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 272635000903 active site 272635000904 motif 3; other site 272635000905 histidyl-tRNA synthetase; Region: hisS; TIGR00442 272635000906 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 272635000907 dimer interface [polypeptide binding]; other site 272635000908 motif 1; other site 272635000909 active site 272635000910 motif 2; other site 272635000911 motif 3; other site 272635000912 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 272635000913 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 272635000914 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272635000915 active site 272635000916 (T/H)XGH motif; other site 272635000917 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 272635000918 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 272635000919 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272635000920 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272635000921 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272635000922 RNA binding surface [nucleotide binding]; other site 272635000923 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 272635000924 active site 272635000925 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 272635000926 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272635000927 dimer interface [polypeptide binding]; other site 272635000928 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272635000929 active site 272635000930 folate binding site [chemical binding]; other site 272635000931 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 272635000932 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 272635000933 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 272635000934 signal recognition particle protein; Provisional; Region: PRK10867 272635000935 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 272635000936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000937 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272635000938 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 272635000939 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 272635000940 putative ligand binding site [chemical binding]; other site 272635000941 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272635000942 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635000943 Walker A/P-loop; other site 272635000944 ATP binding site [chemical binding]; other site 272635000945 Q-loop/lid; other site 272635000946 ABC transporter signature motif; other site 272635000947 Walker B; other site 272635000948 D-loop; other site 272635000949 H-loop/switch region; other site 272635000950 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 272635000951 phosphodiesterase; Provisional; Region: PRK12704 272635000952 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272635000953 TM-ABC transporter signature motif; other site 272635000954 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272635000955 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 272635000956 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272635000957 putative tRNA-binding site [nucleotide binding]; other site 272635000958 B3/4 domain; Region: B3_4; cl11458 272635000959 tRNA synthetase B5 domain; Region: B5; cl08394 272635000960 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 272635000961 motif 1; other site 272635000962 dimer interface [polypeptide binding]; other site 272635000963 active site 272635000964 motif 2; other site 272635000965 motif 3; other site 272635000966 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272635000967 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272635000968 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272635000969 dimer interface [polypeptide binding]; other site 272635000970 motif 1; other site 272635000971 active site 272635000972 motif 2; other site 272635000973 motif 3; other site 272635000974 ribonuclease R; Region: RNase_R; TIGR02063 272635000975 RNB domain; Region: RNB; pfam00773 272635000976 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272635000977 RNA binding site [nucleotide binding]; other site 272635000978 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272635000979 SmpB-tmRNA interface; other site 272635000980 GTPase CgtA; Reviewed; Region: obgE; PRK12297 272635000981 GTP1/OBG; Region: GTP1_OBG; pfam01018 272635000982 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 272635000983 G1 box; other site 272635000984 GTP/Mg2+ binding site [chemical binding]; other site 272635000985 Switch I region; other site 272635000986 G2 box; other site 272635000987 G3 box; other site 272635000988 Switch II region; other site 272635000989 G4 box; other site 272635000990 G5 box; other site 272635000991 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 272635000992 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 272635000993 Phosphopantetheine attachment site; Region: PP-binding; cl09936 272635000994 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 272635000995 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272635000996 hypothetical protein; Provisional; Region: PRK08185 272635000997 intersubunit interface [polypeptide binding]; other site 272635000998 active site 272635000999 zinc binding site [ion binding]; other site 272635001000 Na+ binding site [ion binding]; other site 272635001001 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272635001002 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 272635001003 active site turn [active] 272635001004 phosphorylation site [posttranslational modification] 272635001005 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272635001006 active site 272635001007 trimer interface [polypeptide binding]; other site 272635001008 allosteric site; other site 272635001009 active site lid [active] 272635001010 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272635001011 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 272635001012 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 272635001013 putative active site cavity [active] 272635001014 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272635001015 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272635001016 active site turn [active] 272635001017 phosphorylation site [posttranslational modification] 272635001018 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272635001019 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272635001020 putative active site [active] 272635001021 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272635001022 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272635001023 active site 272635001024 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272635001025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272635001026 Mg2+ binding site [ion binding]; other site 272635001027 G-X-G motif; other site 272635001028 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272635001029 anchoring element; other site 272635001030 dimer interface [polypeptide binding]; other site 272635001031 ATP binding site [chemical binding]; other site 272635001032 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272635001033 active site 272635001034 putative metal-binding site [ion binding]; other site 272635001035 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272635001036 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 272635001037 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 272635001038 CAP-like domain; other site 272635001039 active site 272635001040 primary dimer interface [polypeptide binding]; other site 272635001041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272635001042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272635001043 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 272635001044 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272635001045 interface (dimer of trimers) [polypeptide binding]; other site 272635001046 Substrate-binding/catalytic site; other site 272635001047 Zn-binding sites [ion binding]; other site 272635001048 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272635001049 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39E; cd02424 272635001050 putative active site [active] 272635001051 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 272635001052 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001053 Walker A/P-loop; other site 272635001054 ATP binding site [chemical binding]; other site 272635001055 Q-loop/lid; other site 272635001056 ABC transporter signature motif; other site 272635001057 Walker B; other site 272635001058 D-loop; other site 272635001059 H-loop/switch region; other site 272635001060 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 272635001061 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272635001062 active site 272635001063 catalytic motif [active] 272635001064 Zn binding site [ion binding]; other site 272635001065 GTPase Era; Reviewed; Region: era; PRK00089 272635001066 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272635001067 G1 box; other site 272635001068 GTP/Mg2+ binding site [chemical binding]; other site 272635001069 Switch I region; other site 272635001070 G2 box; other site 272635001071 Switch II region; other site 272635001072 G3 box; other site 272635001073 G4 box; other site 272635001074 G5 box; other site 272635001075 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 272635001076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001077 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 272635001078 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 272635001079 Walker A/P-loop; other site 272635001080 ATP binding site [chemical binding]; other site 272635001081 Q-loop/lid; other site 272635001082 ABC transporter signature motif; other site 272635001083 Walker B; other site 272635001084 D-loop; other site 272635001085 H-loop/switch region; other site 272635001086 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13651 272635001087 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 272635001088 Walker A/P-loop; other site 272635001089 ATP binding site [chemical binding]; other site 272635001090 Q-loop/lid; other site 272635001091 ABC transporter signature motif; other site 272635001092 Walker B; other site 272635001093 D-loop; other site 272635001094 H-loop/switch region; other site 272635001095 Cobalt transport protein; Region: CbiQ; cl00463 272635001096 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 272635001097 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272635001098 nucleotide binding pocket [chemical binding]; other site 272635001099 K-X-D-G motif; other site 272635001100 catalytic site [active] 272635001101 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272635001102 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 272635001103 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272635001104 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272635001105 dimer interface [polypeptide binding]; other site 272635001106 putative anticodon binding site; other site 272635001107 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272635001108 motif 1; other site 272635001109 active site 272635001110 motif 2; other site 272635001111 motif 3; other site 272635001112 Integrase core domain; Region: rve; cl01316 272635001113 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272635001114 Helix-turn-helix domains; Region: HTH; cl00088 272635001115 putative transposase OrfB; Reviewed; Region: PHA02517 272635001116 Integrase core domain; Region: rve; cl01316 272635001117 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 272635001118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272635001119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 272635001120 ATP binding site [chemical binding]; other site 272635001121 putative Mg++ binding site [ion binding]; other site 272635001122 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 272635001123 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 272635001124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635001125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635001126 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 272635001127 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 272635001128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635001129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635001130 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 272635001131 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 272635001132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635001133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635001134 Integrase core domain; Region: rve; cl01316 272635001135 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272635001136 Helix-turn-helix domains; Region: HTH; cl00088 272635001137 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 272635001138 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 272635001139 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272635001140 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 272635001141 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272635001142 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272635001143 dimer interface [polypeptide binding]; other site 272635001144 putative anticodon binding site; other site 272635001145 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272635001146 motif 1; other site 272635001147 active site 272635001148 motif 2; other site 272635001149 motif 3; other site 272635001150 Fic/DOC family; Region: Fic; cl00960 272635001151 elongation factor Tu; Reviewed; Region: PRK00049 272635001152 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 272635001153 G1 box; other site 272635001154 GEF interaction site [polypeptide binding]; other site 272635001155 GTP/Mg2+ binding site [chemical binding]; other site 272635001156 Switch I region; other site 272635001157 G2 box; other site 272635001158 G3 box; other site 272635001159 Switch II region; other site 272635001160 G4 box; other site 272635001161 G5 box; other site 272635001162 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272635001163 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272635001164 Antibiotic Binding Site [chemical binding]; other site 272635001165 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272635001166 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 272635001167 MgtE intracellular N domain; Region: MgtE_N; cl15244 272635001168 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 272635001169 Divalent cation transporter; Region: MgtE; cl00786 272635001170 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272635001171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272635001172 dimer interface [polypeptide binding]; other site 272635001173 conserved gate region; other site 272635001174 putative PBP binding loops; other site 272635001175 ABC-ATPase subunit interface; other site 272635001176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272635001177 dimer interface [polypeptide binding]; other site 272635001178 conserved gate region; other site 272635001179 putative PBP binding loops; other site 272635001180 ABC-ATPase subunit interface; other site 272635001181 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272635001182 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 272635001183 Walker A/P-loop; other site 272635001184 ATP binding site [chemical binding]; other site 272635001185 Q-loop/lid; other site 272635001186 ABC transporter signature motif; other site 272635001187 Walker B; other site 272635001188 D-loop; other site 272635001189 H-loop/switch region; other site 272635001190 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272635001191 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001192 Walker A/P-loop; other site 272635001193 ATP binding site [chemical binding]; other site 272635001194 Q-loop/lid; other site 272635001195 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 272635001196 ABC transporter signature motif; other site 272635001197 Walker B; other site 272635001198 D-loop; other site 272635001199 H-loop/switch region; other site 272635001200 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272635001201 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001202 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272635001203 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272635001204 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272635001205 chromosome segregation protein; Provisional; Region: PRK03918 272635001206 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 272635001207 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 272635001208 Ion channel; Region: Ion_trans_2; cl11596 272635001209 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272635001210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272635001211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272635001212 dimer interface [polypeptide binding]; other site 272635001213 conserved gate region; other site 272635001214 ABC-ATPase subunit interface; other site 272635001215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272635001216 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001217 Walker A/P-loop; other site 272635001218 ATP binding site [chemical binding]; other site 272635001219 Q-loop/lid; other site 272635001220 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001221 ABC transporter signature motif; other site 272635001222 Walker B; other site 272635001223 D-loop; other site 272635001224 H-loop/switch region; other site 272635001225 TOBE domain; Region: TOBE_2; cl01440 272635001226 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 272635001227 elongation factor G; Reviewed; Region: PRK12739 272635001228 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 272635001229 G1 box; other site 272635001230 putative GEF interaction site [polypeptide binding]; other site 272635001231 GTP/Mg2+ binding site [chemical binding]; other site 272635001232 Switch I region; other site 272635001233 G2 box; other site 272635001234 G3 box; other site 272635001235 Switch II region; other site 272635001236 G4 box; other site 272635001237 G5 box; other site 272635001238 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272635001239 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272635001240 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272635001241 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 272635001242 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272635001243 S17 interaction site [polypeptide binding]; other site 272635001244 S8 interaction site; other site 272635001245 16S rRNA interaction site [nucleotide binding]; other site 272635001246 streptomycin interaction site [chemical binding]; other site 272635001247 23S rRNA interaction site [nucleotide binding]; other site 272635001248 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272635001249 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272635001250 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272635001251 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272635001252 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 272635001253 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 272635001254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272635001255 ATP binding site [chemical binding]; other site 272635001256 putative Mg++ binding site [ion binding]; other site 272635001257 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 272635001258 HsdM N-terminal domain; Region: HsdM_N; pfam12161 272635001259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635001260 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272635001261 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272635001262 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272635001263 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001264 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001265 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001266 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001267 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001268 DNA polymerase III PolC; Validated; Region: polC; PRK00448 272635001269 hypothetical protein; Provisional; Region: PRK06148 272635001270 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 272635001271 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 272635001272 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 272635001273 lipoyl attachment site [posttranslational modification]; other site 272635001274 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 272635001275 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272635001276 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 272635001277 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 272635001278 Protein of unknown function (DUF2714); Region: DUF2714; pfam10896 272635001279 ATP synthase; Region: ATP-synt; cl00365 272635001280 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 272635001281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001282 Walker A motif; other site 272635001283 ATP binding site [chemical binding]; other site 272635001284 Walker B motif; other site 272635001285 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 272635001286 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001287 Walker A motif; other site 272635001288 ATP binding site [chemical binding]; other site 272635001289 Walker B motif; other site 272635001290 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272635001291 glycyl-tRNA synthetase; Provisional; Region: PRK04173 272635001292 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 272635001293 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 272635001294 active site 272635001295 motif 2; other site 272635001296 motif 3; other site 272635001297 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 272635001298 anticodon binding site; other site 272635001299 DNA primase, catalytic core; Region: dnaG; TIGR01391 272635001300 CHC2 zinc finger; Region: zf-CHC2; cl15369 272635001301 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272635001302 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272635001303 active site 272635001304 metal binding site [ion binding]; metal-binding site 272635001305 interdomain interaction site; other site 272635001306 RNA polymerase sigma factor; Provisional; Region: PRK05901 272635001307 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272635001308 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272635001309 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272635001310 Uncharacterized conserved protein [Function unknown]; Region: COG0327 272635001311 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 272635001312 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 272635001313 dUTPase; Region: dUTPase_2; pfam08761 272635001314 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272635001315 substrate binding site [chemical binding]; other site 272635001316 dimer interface [polypeptide binding]; other site 272635001317 catalytic triad [active] 272635001318 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 272635001319 Sulfatase; Region: Sulfatase; cl10460 272635001320 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 272635001321 Competence protein; Region: Competence; cl00471 272635001322 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 272635001323 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272635001324 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272635001325 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272635001326 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272635001327 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 272635001328 RmuC family; Region: RmuC; pfam02646 272635001329 DNA polymerase III PolC; Validated; Region: polC; PRK00448 272635001330 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 272635001331 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 272635001332 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 272635001333 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272635001334 dimer interface [polypeptide binding]; other site 272635001335 substrate binding site [chemical binding]; other site 272635001336 metal binding sites [ion binding]; metal-binding site 272635001337 DNA topoisomerase I; Validated; Region: PRK05582 272635001338 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272635001339 active site 272635001340 interdomain interaction site; other site 272635001341 putative metal-binding site [ion binding]; other site 272635001342 nucleotide binding site [chemical binding]; other site 272635001343 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272635001344 domain I; other site 272635001345 DNA binding groove [nucleotide binding] 272635001346 phosphate binding site [ion binding]; other site 272635001347 domain II; other site 272635001348 domain III; other site 272635001349 nucleotide binding site [chemical binding]; other site 272635001350 catalytic site [active] 272635001351 domain IV; other site 272635001352 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272635001353 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 272635001354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635001355 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 272635001356 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 272635001357 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272635001358 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 272635001359 conserved cys residue [active] 272635001360 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 272635001361 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 272635001362 hypothetical protein; Provisional; Region: PRK06148 272635001363 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001364 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 272635001365 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 272635001366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635001367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635001368 hypothetical protein; Provisional; Region: PRK06148 272635001369 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 272635001370 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 272635001371 active site 272635001372 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272635001373 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 272635001374 Predicted integral membrane protein [Function unknown]; Region: COG0392 272635001375 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 272635001376 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272635001377 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272635001378 active site 272635001379 HIGH motif; other site 272635001380 dimer interface [polypeptide binding]; other site 272635001381 KMSKS motif; other site 272635001382 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272635001383 putative tRNA-binding site [nucleotide binding]; other site 272635001384 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 272635001385 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001386 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272635001387 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272635001388 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272635001389 active site 272635001390 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 272635001391 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 272635001392 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272635001393 active site 272635001394 HIGH motif; other site 272635001395 KMSKS motif; other site 272635001396 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272635001397 tRNA binding surface [nucleotide binding]; other site 272635001398 anticodon binding site; other site 272635001399 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272635001400 cell division protein FtsZ; Validated; Region: PRK09330 272635001401 nucleotide binding site [chemical binding]; other site 272635001402 SulA interaction site; other site 272635001403 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 272635001404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635001405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 272635001406 MraZ protein; Region: MraZ; pfam02381 272635001407 MraZ protein; Region: MraZ; pfam02381 272635001408 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272635001409 23S rRNA interface [nucleotide binding]; other site 272635001410 L3 interface [polypeptide binding]; other site 272635001411 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 272635001412 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001413 Walker A/P-loop; other site 272635001414 ATP binding site [chemical binding]; other site 272635001415 Q-loop/lid; other site 272635001416 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 272635001417 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001418 ABC transporter signature motif; other site 272635001419 Walker B; other site 272635001420 D-loop; other site 272635001421 H-loop/switch region; other site 272635001422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272635001423 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272635001424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272635001425 Putative peptidase (DUF31); Region: DUF31; pfam01732 272635001426 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 272635001427 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 272635001428 Treacher Collins syndrome protein Treacle; Region: Treacle; pfam03546 272635001429 transketolase; Reviewed; Region: PRK05899 272635001430 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272635001431 TPP-binding site [chemical binding]; other site 272635001432 dimer interface [polypeptide binding]; other site 272635001433 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272635001434 PYR/PP interface [polypeptide binding]; other site 272635001435 dimer interface [polypeptide binding]; other site 272635001436 TPP binding site [chemical binding]; other site 272635001437 elongation factor P; Validated; Region: PRK00529 272635001438 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272635001439 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272635001440 RNA binding site [nucleotide binding]; other site 272635001441 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272635001442 RNA binding site [nucleotide binding]; other site 272635001443 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272635001444 Domain of unknown function DUF21; Region: DUF21; pfam01595 272635001445 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272635001446 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272635001447 replicative DNA helicase; Region: DnaB; TIGR00665 272635001448 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272635001449 Walker A motif; other site 272635001450 ATP binding site [chemical binding]; other site 272635001451 Walker B motif; other site 272635001452 DNA binding loops [nucleotide binding] 272635001453 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272635001454 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272635001455 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 272635001456 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 272635001457 DHH family; Region: DHH; pfam01368 272635001458 enolase; Provisional; Region: eno; PRK00077 272635001459 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272635001460 dimer interface [polypeptide binding]; other site 272635001461 metal binding site [ion binding]; metal-binding site 272635001462 substrate binding pocket [chemical binding]; other site 272635001463 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 272635001464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272635001465 Walker A motif; other site 272635001466 ATP binding site [chemical binding]; other site 272635001467 Walker B motif; other site 272635001468 arginine finger; other site 272635001469 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272635001470 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001471 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001472 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 272635001473 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 272635001474 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 272635001475 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 272635001476 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 272635001477 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001478 large tegument protein UL36; Provisional; Region: PHA03247 272635001479 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001480 ARC105 or Med15 subunit of Mediator complex non-fungal; Region: Med15; pfam09606 272635001481 TIGR02302 family protein; Region: aProt_lowcomp 272635001482 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272635001483 DNA binding site [nucleotide binding] 272635001484 Int/Topo IB signature motif; other site 272635001485 active site 272635001486 elongation factor Ts; Provisional; Region: tsf; PRK09377 272635001487 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 272635001488 Elongation factor TS; Region: EF_TS; pfam00889 272635001489 Elongation factor TS; Region: EF_TS; pfam00889 272635001490 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272635001491 rRNA interaction site [nucleotide binding]; other site 272635001492 S8 interaction site; other site 272635001493 putative laminin-1 binding site; other site 272635001494 DNA polymerase III PolC; Validated; Region: polC; PRK00448 272635001495 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272635001496 active site 272635001497 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272635001498 folate binding site [chemical binding]; other site 272635001499 NADP+ binding site [chemical binding]; other site 272635001500 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272635001501 dimerization interface [polypeptide binding]; other site 272635001502 active site 272635001503 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 272635001504 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272635001505 dimer interface [polypeptide binding]; other site 272635001506 putative radical transfer pathway; other site 272635001507 diiron center [ion binding]; other site 272635001508 tyrosyl radical; other site 272635001509 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272635001510 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 272635001511 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 272635001512 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 272635001513 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 272635001514 RNA methyltransferase, RsmE family; Region: TIGR00046 272635001515 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 272635001516 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272635001517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272635001518 active site 272635001519 motif I; other site 272635001520 motif II; other site 272635001521 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 272635001522 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 272635001523 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 272635001524 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 272635001525 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 272635001526 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 272635001527 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 272635001528 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 272635001529 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272635001530 DNA binding site [nucleotide binding] 272635001531 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272635001532 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 272635001533 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Provisional; Region: PRK14844 272635001534 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272635001535 RPB1 interaction site [polypeptide binding]; other site 272635001536 RPB10 interaction site [polypeptide binding]; other site 272635001537 RPB11 interaction site [polypeptide binding]; other site 272635001538 RPB3 interaction site [polypeptide binding]; other site 272635001539 RPB12 interaction site [polypeptide binding]; other site 272635001540 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 272635001541 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 272635001542 hypothetical protein; Provisional; Region: PRK07143 272635001543 Cytidylyltransferase-like domain; Region: cytidylyltransferase_like; cd02039 272635001544 active site 272635001545 (T/H)XGH motif; other site 272635001546 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272635001547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272635001548 active site 272635001549 motif I; other site 272635001550 motif II; other site 272635001551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272635001552 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02193 272635001553 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 272635001554 RNA binding site [nucleotide binding]; other site 272635001555 active site 272635001556 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 272635001557 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 272635001558 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 272635001559 Substrate-binding site [chemical binding]; other site 272635001560 Substrate specificity [chemical binding]; other site 272635001561 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272635001562 domain; Region: GreA_GreB_N; pfam03449 272635001563 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272635001564 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 272635001565 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272635001566 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 272635001567 motif 1; other site 272635001568 active site 272635001569 motif 2; other site 272635001570 motif 3; other site 272635001571 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 272635001572 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 272635001573 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272635001574 Ligand Binding Site [chemical binding]; other site 272635001575 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 272635001576 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272635001577 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272635001578 alphaNTD - beta interaction site [polypeptide binding]; other site 272635001579 alphaNTD homodimer interface [polypeptide binding]; other site 272635001580 alphaNTD - beta' interaction site [polypeptide binding]; other site 272635001581 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 272635001582 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 272635001583 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 272635001584 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 272635001585 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 272635001586 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272635001587 rRNA binding site [nucleotide binding]; other site 272635001588 predicted 30S ribosome binding site; other site 272635001589 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272635001590 active site 272635001591 adenylate kinases; Region: adk; TIGR01351 272635001592 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272635001593 AMP-binding site [chemical binding]; other site 272635001594 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272635001595 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272635001596 SecY translocase; Region: SecY; pfam00344 272635001597 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 272635001598 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272635001599 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272635001600 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272635001601 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272635001602 23S rRNA interface [nucleotide binding]; other site 272635001603 L21e interface [polypeptide binding]; other site 272635001604 5S rRNA interface [nucleotide binding]; other site 272635001605 L27 interface [polypeptide binding]; other site 272635001606 L5 interface [polypeptide binding]; other site 272635001607 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272635001608 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272635001609 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272635001610 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 272635001611 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 272635001612 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272635001613 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272635001614 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272635001615 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 272635001616 KOW motif; Region: KOW; cl00354 272635001617 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 272635001618 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 272635001619 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272635001620 23S rRNA interface [nucleotide binding]; other site 272635001621 putative translocon interaction site; other site 272635001622 signal recognition particle (SRP54) interaction site; other site 272635001623 L23 interface [polypeptide binding]; other site 272635001624 trigger factor interaction site; other site 272635001625 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272635001626 23S rRNA interface [nucleotide binding]; other site 272635001627 5S rRNA interface [nucleotide binding]; other site 272635001628 putative antibiotic binding site [chemical binding]; other site 272635001629 L25 interface [polypeptide binding]; other site 272635001630 L27 interface [polypeptide binding]; other site 272635001631 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272635001632 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272635001633 G-X-X-G motif; other site 272635001634 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272635001635 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272635001636 putative translocon binding site; other site 272635001637 protein-rRNA interface [nucleotide binding]; other site 272635001638 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 272635001639 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272635001640 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272635001641 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272635001642 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 272635001643 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 272635001644 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 272635001645 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 272635001646 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 272635001647 active site 272635001648 substrate binding pocket [chemical binding]; other site 272635001649 homodimer interaction site [polypeptide binding]; other site 272635001650 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 272635001651 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 272635001652 P-loop; other site 272635001653 active site 272635001654 phosphorylation site [posttranslational modification] 272635001655 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272635001656 active site 272635001657 phosphorylation site [posttranslational modification] 272635001658 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 272635001659 active site 272635001660 dimer interface [polypeptide binding]; other site 272635001661 magnesium binding site [ion binding]; other site 272635001662 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 272635001663 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 272635001664 AP (apurinic/apyrimidinic) site pocket; other site 272635001665 DNA interaction; other site 272635001666 Metal-binding active site; metal-binding site 272635001667 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 272635001668 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 272635001669 intersubunit interface [polypeptide binding]; other site 272635001670 active site 272635001671 Zn2+ binding site [ion binding]; other site 272635001672 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 272635001673 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 272635001674 active site 272635001675 ADP/pyrophosphate binding site [chemical binding]; other site 272635001676 dimerization interface [polypeptide binding]; other site 272635001677 allosteric effector site; other site 272635001678 fructose-1,6-bisphosphate binding site; other site 272635001679 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272635001680 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 272635001681 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 272635001682 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 272635001683 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272635001684 dimerization domain swap beta strand [polypeptide binding]; other site 272635001685 regulatory protein interface [polypeptide binding]; other site 272635001686 active site 272635001687 regulatory phosphorylation site [posttranslational modification]; other site 272635001688 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 272635001689 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272635001690 dimer interface [polypeptide binding]; other site 272635001691 ssDNA binding site [nucleotide binding]; other site 272635001692 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272635001693 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 272635001694 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 272635001695 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 272635001696 Smr domain; Region: Smr; cl02619 272635001697 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272635001698 ligand binding site [chemical binding]; other site 272635001699 active site 272635001700 UGI interface [polypeptide binding]; other site 272635001701 catalytic site [active] 272635001702 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272635001703 TM-ABC transporter signature motif; other site 272635001704 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272635001705 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272635001706 TM-ABC transporter signature motif; other site 272635001707 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272635001708 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 272635001709 Walker A/P-loop; other site 272635001710 ATP binding site [chemical binding]; other site 272635001711 Q-loop/lid; other site 272635001712 ABC transporter signature motif; other site 272635001713 Walker B; other site 272635001714 D-loop; other site 272635001715 H-loop/switch region; other site 272635001716 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 272635001717 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272635001718 endonuclease IV; Provisional; Region: PRK01060 272635001719 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 272635001720 AP (apurinic/apyrimidinic) site pocket; other site 272635001721 DNA interaction; other site 272635001722 Metal-binding active site; metal-binding site 272635001723 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272635001724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272635001725 DNA binding site [nucleotide binding] 272635001726 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 272635001727 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272635001728 homodimer interface [polypeptide binding]; other site 272635001729 NAD binding pocket [chemical binding]; other site 272635001730 ATP binding pocket [chemical binding]; other site 272635001731 Mg binding site [ion binding]; other site 272635001732 active-site loop [active] 272635001733 Domain of unknown function DUF28; Region: DUF28; cl00361 272635001734 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272635001735 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001736 Walker A/P-loop; other site 272635001737 ATP binding site [chemical binding]; other site 272635001738 Q-loop/lid; other site 272635001739 ABC transporter signature motif; other site 272635001740 Walker B; other site 272635001741 D-loop; other site 272635001742 H-loop/switch region; other site 272635001743 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272635001744 FtsX-like permease family; Region: FtsX; cl15850 272635001745 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272635001746 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001747 Walker A/P-loop; other site 272635001748 ATP binding site [chemical binding]; other site 272635001749 Q-loop/lid; other site 272635001750 ABC transporter signature motif; other site 272635001751 Walker B; other site 272635001752 D-loop; other site 272635001753 H-loop/switch region; other site 272635001754 FtsX-like permease family; Region: FtsX; pfam02687 272635001755 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272635001756 Catalytic site [active] 272635001757 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272635001758 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272635001759 active site 272635001760 catalytic site [active] 272635001761 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272635001762 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272635001763 active site 272635001764 catalytic site [active] 272635001765 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 272635001766 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272635001767 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272635001768 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272635001769 beta-phosphoglucomutase; Region: bPGM; TIGR01990 272635001770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272635001771 motif II; other site 272635001772 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 272635001773 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272635001774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272635001775 dimer interface [polypeptide binding]; other site 272635001776 conserved gate region; other site 272635001777 ABC-ATPase subunit interface; other site 272635001778 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272635001779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272635001780 dimer interface [polypeptide binding]; other site 272635001781 conserved gate region; other site 272635001782 ABC-ATPase subunit interface; other site 272635001783 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272635001784 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 272635001785 Walker A/P-loop; other site 272635001786 ATP binding site [chemical binding]; other site 272635001787 Q-loop/lid; other site 272635001788 ABC transporter signature motif; other site 272635001789 Walker B; other site 272635001790 D-loop; other site 272635001791 H-loop/switch region; other site 272635001792 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272635001793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272635001794 DNA-binding site [nucleotide binding]; DNA binding site 272635001795 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 272635001796 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 272635001797 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 272635001798 Ca binding site [ion binding]; other site 272635001799 active site 272635001800 catalytic site [active] 272635001801 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272635001802 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 272635001803 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272635001804 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 272635001805 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272635001806 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 272635001807 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001808 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001809 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001810 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001811 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001812 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001813 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001814 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001815 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001816 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001817 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 272635001818 Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488 272635001819 putative catalytic residues [active] 272635001820 putative active site [active] 272635001821 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 272635001822 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272635001823 RuvA N terminal domain; Region: RuvA_N; pfam01330 272635001824 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272635001825 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272635001826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272635001827 Walker A motif; other site 272635001828 ATP binding site [chemical binding]; other site 272635001829 Walker B motif; other site 272635001830 arginine finger; other site 272635001831 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272635001832 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 272635001833 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 272635001834 Protein export membrane protein; Region: SecD_SecF; cl14618 272635001835 Protein export membrane protein; Region: SecD_SecF; cl14618 272635001836 Domain of unknown function (DUF386); Region: DUF386; cl01047 272635001837 Amino acid permease; Region: AA_permease; cl00524 272635001838 PHP domain; Region: PHP; pfam02811 272635001839 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001840 Walker B; other site 272635001841 D-loop; other site 272635001842 H-loop/switch region; other site 272635001843 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 272635001844 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272635001845 putative active site [active] 272635001846 catalytic site [active] 272635001847 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272635001848 putative active site [active] 272635001849 catalytic site [active] 272635001850 CTP synthetase; Validated; Region: pyrG; PRK05380 272635001851 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272635001852 Catalytic site [active] 272635001853 active site 272635001854 UTP binding site [chemical binding]; other site 272635001855 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272635001856 active site 272635001857 putative oxyanion hole; other site 272635001858 catalytic triad [active] 272635001859 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 272635001860 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272635001861 active site 272635001862 HIGH motif; other site 272635001863 nucleotide binding site [chemical binding]; other site 272635001864 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272635001865 active site 272635001866 KMSKS motif; other site 272635001867 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272635001868 tRNA binding surface [nucleotide binding]; other site 272635001869 anticodon binding site; other site 272635001870 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272635001871 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 272635001872 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001873 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001874 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635001875 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 272635001876 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272635001877 putative active site [active] 272635001878 metal binding site [ion binding]; metal-binding site 272635001879 homodimer binding site [polypeptide binding]; other site 272635001880 Ribosome-binding factor A; Region: RBFA; cl00542 272635001881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 272635001882 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272635001883 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 272635001884 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272635001885 P loop; other site 272635001886 GTP binding site [chemical binding]; other site 272635001887 DNA polymerase III PolC; Validated; Region: polC; PRK00448 272635001888 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272635001889 generic binding surface II; other site 272635001890 generic binding surface I; other site 272635001891 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272635001892 active site 272635001893 substrate binding site [chemical binding]; other site 272635001894 catalytic site [active] 272635001895 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272635001896 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272635001897 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272635001898 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272635001899 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 272635001900 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 272635001901 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272635001902 ATP binding site [chemical binding]; other site 272635001903 putative Mg++ binding site [ion binding]; other site 272635001904 HsdM N-terminal domain; Region: HsdM_N; pfam12161 272635001905 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 272635001906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272635001907 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272635001908 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272635001909 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272635001910 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 272635001911 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272635001912 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272635001913 HIGH motif; other site 272635001914 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272635001915 active site 272635001916 KMSKS motif; other site 272635001917 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272635001918 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272635001919 substrate binding site [chemical binding]; other site 272635001920 hexamer interface [polypeptide binding]; other site 272635001921 metal binding site [ion binding]; metal-binding site 272635001922 Predicted GTPases [General function prediction only]; Region: COG1162 272635001923 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 272635001924 GTPase/OB domain interface [polypeptide binding]; other site 272635001925 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272635001926 GTP/Mg2+ binding site [chemical binding]; other site 272635001927 G4 box; other site 272635001928 G5 box; other site 272635001929 G1 box; other site 272635001930 Switch I region; other site 272635001931 G2 box; other site 272635001932 G3 box; other site 272635001933 Switch II region; other site 272635001934 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272635001935 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272635001936 active site 272635001937 ATP binding site [chemical binding]; other site 272635001938 substrate binding site [chemical binding]; other site 272635001939 activation loop (A-loop); other site 272635001940 Protein phosphatase 2C; Region: PP2C; pfam00481 272635001941 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272635001942 active site 272635001943 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 272635001944 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272635001945 catalytic site [active] 272635001946 G-X2-G-X-G-K; other site 272635001947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272635001948 S-adenosylmethionine binding site [chemical binding]; other site 272635001949 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272635001950 active site 272635001951 catalytic residues [active] 272635001952 metal binding site [ion binding]; metal-binding site 272635001953 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001954 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 272635001955 Walker A/P-loop; other site 272635001956 ATP binding site [chemical binding]; other site 272635001957 Q-loop/lid; other site 272635001958 ABC transporter signature motif; other site 272635001959 Walker B; other site 272635001960 D-loop; other site 272635001961 H-loop/switch region; other site 272635001962 ABC transporter; Region: ABC_tran_2; pfam12848 272635001963 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 272635001964 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272635001965 DHH family; Region: DHH; pfam01368 272635001966 DHHA1 domain; Region: DHHA1; pfam02272 272635001967 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272635001968 putative catalytic site [active] 272635001969 putative metal binding site [ion binding]; other site 272635001970 putative phosphate binding site [ion binding]; other site 272635001971 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 272635001972 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272635001973 putative catalytic site [active] 272635001974 putative metal binding site [ion binding]; other site 272635001975 putative phosphate binding site [ion binding]; other site 272635001976 Deoxyribonuclease 1 and related proteins; Region: DNase1-like; cd09075 272635001977 putative active site [active] 272635001978 putative catalytic site [active] 272635001979 putative Mg binding site IVb [ion binding]; other site 272635001980 putative phosphate binding site [ion binding]; other site 272635001981 DNA binding site [nucleotide binding] 272635001982 Ca binding site II [ion binding]; other site 272635001983 putative Mg binding site IVa [ion binding]; other site 272635001984 Ca binding site I [ion binding]; other site 272635001985 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 272635001986 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 272635001987 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272635001988 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635001989 Family description; Region: UvrD_C_2; cl15862 272635001990 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 272635001991 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272635001992 alpha subunit interaction interface [polypeptide binding]; other site 272635001993 Walker A motif; other site 272635001994 ATP binding site [chemical binding]; other site 272635001995 Walker B motif; other site 272635001996 inhibitor binding site; inhibition site 272635001997 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272635001998 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 272635001999 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635002000 Walker A motif; other site 272635002001 ATP binding site [chemical binding]; other site 272635002002 Walker B motif; other site 272635002003 Protein of unknown function (DUF2714); Region: DUF2714; pfam10896 272635002004 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272635002005 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272635002006 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272635002007 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272635002008 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272635002009 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272635002010 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272635002011 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 272635002012 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272635002013 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272635002014 catalytic residues [active] 272635002015 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 272635002016 dimer interface [polypeptide binding]; other site 272635002017 catalytic triad [active] 272635002018 peroxidatic and resolving cysteines [active] 272635002019 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272635002020 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272635002021 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 272635002022 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 272635002023 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 272635002024 HPr kinase/phosphorylase; Provisional; Region: PRK05428 272635002025 DRTGG domain; Region: DRTGG; cl12147 272635002026 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272635002027 Hpr binding site; other site 272635002028 active site 272635002029 homohexamer subunit interaction site [polypeptide binding]; other site 272635002030 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 272635002031 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272635002032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635002033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635002034 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272635002035 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 272635002036 Walker A/P-loop; other site 272635002037 ATP binding site [chemical binding]; other site 272635002038 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 272635002039 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 272635002040 Q-loop/lid; other site 272635002041 ABC transporter signature motif; other site 272635002042 Walker B; other site 272635002043 D-loop; other site 272635002044 H-loop/switch region; other site 272635002045 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272635002046 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272635002047 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272635002048 RNA binding surface [nucleotide binding]; other site 272635002049 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 272635002050 THUMP domain; Region: THUMP; cl12076 272635002051 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 272635002052 Ligand Binding Site [chemical binding]; other site 272635002053 DNA polymerase III DnaE; Validated; Region: dnaE; PRK07135 272635002054 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 272635002055 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272635002056 5'-3' exonuclease; Region: 53EXOc; smart00475 272635002057 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272635002058 active site 272635002059 metal binding site 1 [ion binding]; metal-binding site 272635002060 putative 5' ssDNA interaction site; other site 272635002061 metal binding site 3; metal-binding site 272635002062 metal binding site 2 [ion binding]; metal-binding site 272635002063 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272635002064 putative DNA binding site [nucleotide binding]; other site 272635002065 putative metal binding site [ion binding]; other site 272635002066 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272635002067 CoA-binding site [chemical binding]; other site 272635002068 ATP-binding [chemical binding]; other site 272635002069 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 272635002070 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 272635002071 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272635002072 interface (dimer of trimers) [polypeptide binding]; other site 272635002073 Substrate-binding/catalytic site; other site 272635002074 Zn-binding sites [ion binding]; other site 272635002075 Chromate transporter; Region: Chromate_transp; pfam02417 272635002076 Chromate transporter; Region: Chromate_transp; pfam02417 272635002077 Sulfatase; Region: Sulfatase; cl10460 272635002078 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 272635002079 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 272635002080 oligomer interface [polypeptide binding]; other site 272635002081 active site 272635002082 metal binding site [ion binding]; metal-binding site 272635002083 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 272635002084 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272635002085 HSP70 interaction site [polypeptide binding]; other site 272635002086 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272635002087 Zn binding sites [ion binding]; other site 272635002088 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272635002089 dimer interface [polypeptide binding]; other site 272635002090 Merozoite Surface Antigen 2 (MSA-2) family; Region: MSA_2; pfam00985 272635002091 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 272635002092 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 272635002093 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272635002094 MatE; Region: MatE; cl10513 272635002095 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272635002096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272635002097 ATP binding site [chemical binding]; other site 272635002098 Mg2+ binding site [ion binding]; other site 272635002099 G-X-G motif; other site 272635002100 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272635002101 anchoring element; other site 272635002102 dimer interface [polypeptide binding]; other site 272635002103 ATP binding site [chemical binding]; other site 272635002104 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272635002105 active site 272635002106 putative metal-binding site [ion binding]; other site 272635002107 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272635002108 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 272635002109 active site 272635002110 ATP binding site [chemical binding]; other site 272635002111 substrate binding site [chemical binding]; other site 272635002112 dimer interface [polypeptide binding]; other site 272635002113 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272635002114 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635002115 Walker A/P-loop; other site 272635002116 ATP binding site [chemical binding]; other site 272635002117 Q-loop/lid; other site 272635002118 ABC transporter signature motif; other site 272635002119 Walker B; other site 272635002120 D-loop; other site 272635002121 H-loop/switch region; other site 272635002122 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272635002123 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 272635002124 Walker A/P-loop; other site 272635002125 ATP binding site [chemical binding]; other site 272635002126 Q-loop/lid; other site 272635002127 ABC transporter signature motif; other site 272635002128 Walker B; other site 272635002129 D-loop; other site 272635002130 H-loop/switch region; other site 272635002131 Domain of unknown function DUF31; Region: DUF31; pfam01732 272635002132 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272635002133 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272635002134 active site 272635002135 HIGH motif; other site 272635002136 dimer interface [polypeptide binding]; other site 272635002137 KMSKS motif; other site 272635002138 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 272635002139 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 272635002140 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272635002141 active site 272635002142 dimer interface [polypeptide binding]; other site 272635002143 motif 1; other site 272635002144 motif 2; other site 272635002145 motif 3; other site 272635002146 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272635002147 anticodon binding site; other site 272635002148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272635002149 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 272635002150 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 272635002151 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272635002152 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272635002153 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272635002154 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 272635002155 active site 272635002156 P-loop; other site 272635002157 phosphorylation site [posttranslational modification] 272635002158 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272635002159 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272635002160 putative active site [active] 272635002161 putative transposase OrfB; Reviewed; Region: PHA02517 272635002162 Integrase core domain; Region: rve; cl01316 272635002163 LemA family; Region: LemA; cl00742 272635002164 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272635002165 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 272635002166 dimer interface [polypeptide binding]; other site 272635002167 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272635002168 NAD binding site [chemical binding]; other site 272635002169 substrate binding site [chemical binding]; other site 272635002170 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272635002171 E3 interaction surface; other site 272635002172 lipoyl attachment site [posttranslational modification]; other site 272635002173 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 272635002174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635002175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272635002176 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272635002177 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 272635002178 e3 binding domain; Region: E3_binding; pfam02817 272635002179 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 272635002180 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272635002181 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272635002182 alpha subunit interface [polypeptide binding]; other site 272635002183 TPP binding site [chemical binding]; other site 272635002184 heterodimer interface [polypeptide binding]; other site 272635002185 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272635002186 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 272635002187 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272635002188 tetramer interface [polypeptide binding]; other site 272635002189 TPP-binding site [chemical binding]; other site 272635002190 heterodimer interface [polypeptide binding]; other site 272635002191 phosphorylation loop region [posttranslational modification] 272635002192 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 272635002193 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14261 272635002194 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272635002195 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635002196 Family description; Region: UvrD_C_2; cl15862 272635002197 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272635002198 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 272635002199 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 272635002200 putative dimer interface [polypeptide binding]; other site 272635002201 putative anticodon binding site; other site 272635002202 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272635002203 homodimer interface [polypeptide binding]; other site 272635002204 motif 1; other site 272635002205 motif 2; other site 272635002206 active site 272635002207 motif 3; other site 272635002208 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 272635002209 putative active site [active] 272635002210 putative FMN binding site [chemical binding]; other site 272635002211 putative substrate binding site [chemical binding]; other site 272635002212 putative catalytic residue [active] 272635002213 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272635002214 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 272635002215 Walker A/P-loop; other site 272635002216 ATP binding site [chemical binding]; other site 272635002217 Q-loop/lid; other site 272635002218 ABC transporter signature motif; other site 272635002219 Walker B; other site 272635002220 D-loop; other site 272635002221 H-loop/switch region; other site 272635002222 FtsX-like permease family; Region: FtsX; cl15850 272635002223 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 272635002224 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 272635002225 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272635002226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272635002227 Walker B motif; other site 272635002228 arginine finger; other site 272635002229 Peptidase family M41; Region: Peptidase_M41; pfam01434 272635002230 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272635002231 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272635002232 Ligand Binding Site [chemical binding]; other site 272635002233 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272635002234 putative active site [active] 272635002235 catalytic residue [active] 272635002236 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 272635002237 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272635002238 ATP binding site [chemical binding]; other site 272635002239 putative Mg++ binding site [ion binding]; other site