-- dump date 20111121_013433 -- class Genbank::misc_feature -- table misc_feature_note -- id note 768700000001 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cl02940 768700000002 putative DNA binding surface [nucleotide binding]; other site 768700000003 dimer interface [polypeptide binding]; other site 768700000004 beta-clamp/clamp loader binding surface; other site 768700000005 beta-clamp/translesion DNA polymerase binding surface; other site 768700000006 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 768700000007 HrcA protein C terminal domain; Region: HrcA; pfam01628 768700000008 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768700000009 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 768700000010 Walker A/P-loop; other site 768700000011 ATP binding site [chemical binding]; other site 768700000012 Q-loop/lid; other site 768700000013 ABC transporter signature motif; other site 768700000014 Walker B; other site 768700000015 D-loop; other site 768700000016 H-loop/switch region; other site 768700000017 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 768700000018 NusG family protein; Region: NusG_myco; TIGR01956 768700000019 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 768700000020 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 768700000021 HPr interaction site; other site 768700000022 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768700000023 active site 768700000024 phosphorylation site [posttranslational modification] 768700000025 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768700000026 prolyl-tRNA synthetase; Provisional; Region: PRK08661 768700000027 motif 1; other site 768700000028 dimer interface [polypeptide binding]; other site 768700000029 active site 768700000030 motif 2; other site 768700000031 motif 3; other site 768700000032 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266 768700000033 anticodon binding site; other site 768700000034 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 768700000035 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 768700000036 active site 768700000037 dimer interface [polypeptide binding]; other site 768700000038 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 768700000039 dimer interface [polypeptide binding]; other site 768700000040 active site 768700000041 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 768700000042 putative active site [active] 768700000043 catalytic site [active] 768700000044 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 768700000045 putative active site [active] 768700000046 catalytic site [active] 768700000047 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 768700000048 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768700000049 active site 768700000050 KMSKS motif; other site 768700000051 signal recognition particle protein; Region: ffh; TIGR00959 768700000052 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 768700000053 Signal peptide binding domain; Region: SRP_SPB; pfam02978 768700000054 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 768700000055 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768700000056 dimer interface [polypeptide binding]; other site 768700000057 ssDNA binding site [nucleotide binding]; other site 768700000058 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768700000059 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 768700000060 replicative DNA helicase; Region: DnaB; TIGR00665 768700000061 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768700000062 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 768700000063 Walker A motif; other site 768700000064 ATP binding site [chemical binding]; other site 768700000065 Walker B motif; other site 768700000066 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768700000067 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 768700000068 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768700000069 NAD(P) binding site [chemical binding]; other site 768700000070 catalytic residues [active] 768700000071 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 768700000072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768700000073 ATP binding site [chemical binding]; other site 768700000074 Mg2+ binding site [ion binding]; other site 768700000075 G-X-G motif; other site 768700000076 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 768700000077 ATP binding site [chemical binding]; other site 768700000078 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 768700000079 active site 768700000080 putative metal-binding site [ion binding]; other site 768700000081 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768700000082 DNA gyrase subunit A; Validated; Region: PRK05560 768700000083 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 768700000084 CAP-like domain; other site 768700000085 Active site [active] 768700000086 primary dimer interface [polypeptide binding]; other site 768700000087 DNA gyrase subunit A; Validated; Region: PRK05560 768700000088 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768700000089 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768700000090 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2)...; Region: phosphohexomutase; cl03757 768700000091 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 768700000092 active site 768700000093 substrate binding site [chemical binding]; other site 768700000094 metal binding site [ion binding]; metal-binding site 768700000095 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 768700000096 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 768700000097 active site 768700000098 HIGH motif; other site 768700000099 dimer interface [polypeptide binding]; other site 768700000100 KMSKS motif; other site 768700000101 The Obg-like subfamily consists of five well-delimited, ancient subfamilies, namely Obg, DRG, YyaF/YchF, Ygr210, and NOG1. Four of these groups (Obg, DRG, YyaF/YchF, and Ygr210) are characterized by a distinct glycine-rich motif immediately following...; Region: Obg_like; cd01881 768700000102 G1 box; other site 768700000103 GTP/Mg2+ binding site [chemical binding]; other site 768700000104 Switch I region; other site 768700000105 G2 box; other site 768700000106 Switch II region; other site 768700000107 G3 box; other site 768700000108 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 768700000109 G4 box; other site 768700000110 G5 box; other site 768700000111 Thymidine kinase; Region: TK; cl00631 768700000112 Membrane GTPase LepA [Cell envelope biogenesis, outer membrane]; Region: LepA; COG0481 768700000113 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 768700000114 G1 box; other site 768700000115 GTP/Mg2+ binding site [chemical binding]; other site 768700000116 G2 box; other site 768700000117 Switch I region; other site 768700000118 G3 box; other site 768700000119 Switch II region; other site 768700000120 G4 box; other site 768700000121 G5 box; other site 768700000122 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 768700000123 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to...; Region: Elongation_Factor_C; cl02785 768700000124 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 768700000125 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 768700000126 substrate binding site [chemical binding]; other site 768700000127 dimer interface [polypeptide binding]; other site 768700000128 catalytic triad [active] 768700000129 Sulfatase; Region: Sulfatase; cl10460 768700000130 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 768700000131 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 768700000132 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 768700000133 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 768700000134 Walker A/P-loop; other site 768700000135 ATP binding site [chemical binding]; other site 768700000136 Q-loop/lid; other site 768700000137 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 768700000138 ABC transporter signature motif; other site 768700000139 Walker B; other site 768700000140 D-loop; other site 768700000141 H-loop/switch region; other site 768700000142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 768700000143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 768700000144 dimer interface [polypeptide binding]; other site 768700000145 conserved gate region; other site 768700000146 putative PBP binding loops; other site 768700000147 ABC-ATPase subunit interface; other site 768700000148 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768700000149 UGMP family protein; Validated; Region: PRK09604 768700000150 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 768700000151 S-adenosylmethionine synthetase; Validated; Region: PRK05250 768700000152 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 768700000153 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 768700000154 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 768700000155 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 768700000156 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 768700000157 dimer interface [polypeptide binding]; other site 768700000158 motif 1; other site 768700000159 active site 768700000160 motif 2; other site 768700000161 motif 3; other site 768700000162 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 768700000163 PhoU domain; Region: PhoU; pfam01895 768700000164 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 768700000165 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768700000166 Walker A/P-loop; other site 768700000167 ATP binding site [chemical binding]; other site 768700000168 Q-loop/lid; other site 768700000169 ABC transporter signature motif; other site 768700000170 Walker B; other site 768700000171 D-loop; other site 768700000172 H-loop/switch region; other site 768700000173 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768700000174 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 768700000175 Walker A/P-loop; other site 768700000176 ATP binding site [chemical binding]; other site 768700000177 Q-loop/lid; other site 768700000178 ABC transporter signature motif; other site 768700000179 Walker B; other site 768700000180 D-loop; other site 768700000181 H-loop/switch region; other site 768700000182 outer membrane lipoprotein; Provisional; Region: PRK11023 768700000183 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 768700000184 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 768700000185 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768700000186 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000187 5'-3' exonuclease; Region: 53EXOc; smart00475 768700000188 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768700000189 active site 768700000190 metal binding site 1 [ion binding]; metal-binding site 768700000191 putative 5' ssDNA interaction site; other site 768700000192 metal binding site 3; metal-binding site 768700000193 metal binding site 2 [ion binding]; metal-binding site 768700000194 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768700000195 putative DNA binding site [nucleotide binding]; other site 768700000196 putative metal binding site [ion binding]; other site 768700000197 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000198 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000199 HsdM N-terminal domain; Region: HsdM_N; pfam12161 768700000200 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 768700000201 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 768700000202 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 768700000203 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 768700000204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768700000205 ATP binding site [chemical binding]; other site 768700000206 putative Mg++ binding site [ion binding]; other site 768700000207 hypothetical protein; Provisional; Region: PRK12705 768700000208 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768700000209 hypothetical protein; Provisional; Region: PRK12705 768700000210 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768700000211 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 768700000212 active site 768700000213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 768700000214 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768700000215 active site 768700000216 motif I; other site 768700000217 motif II; other site 768700000218 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 768700000219 DHH family; Region: DHH; pfam01368 768700000220 DHHA1 domain; Region: DHHA1; pfam02272 768700000221 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 768700000222 glycerol kinase-like protein; Provisional; Region: PTZ00294 768700000223 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 768700000224 elongation factor Tu; Reviewed; Region: PRK00049 768700000225 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 768700000226 G1 box; other site 768700000227 GEF interaction site [polypeptide binding]; other site 768700000228 GTP/Mg2+ binding site [chemical binding]; other site 768700000229 Switch I region; other site 768700000230 G2 box; other site 768700000231 G3 box; other site 768700000232 Switch II region; other site 768700000233 G4 box; other site 768700000234 G5 box; other site 768700000235 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 768700000236 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 768700000237 Antibiotic Binding Site [chemical binding]; other site 768700000238 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 768700000239 adenylosuccinate synthetase; Provisional; Region: PRK01117 768700000240 GDP-binding site [chemical binding]; other site 768700000241 ACT binding site; other site 768700000242 IMP binding site; other site 768700000243 S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic...; Region: S15_NS1_EPRS_RNA-bind; cl00349 768700000244 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 768700000245 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 768700000246 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 768700000247 23S rRNA interface [nucleotide binding]; other site 768700000248 L7/L12 interface [polypeptide binding]; other site 768700000249 putative thiostrepton binding site; other site 768700000250 L25 interface [polypeptide binding]; other site 768700000251 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 768700000252 mRNA/rRNA interface [nucleotide binding]; other site 768700000253 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 768700000254 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 768700000255 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 768700000256 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768700000257 active site 768700000258 HIGH motif; other site 768700000259 nucleotide binding site [chemical binding]; other site 768700000260 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768700000261 active site 768700000262 KMSKS motif; other site 768700000263 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 768700000264 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 768700000265 NAD binding site [chemical binding]; other site 768700000266 dimer interface [polypeptide binding]; other site 768700000267 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768700000268 substrate binding site [chemical binding]; other site 768700000269 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 768700000270 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768700000271 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 768700000272 active site 768700000273 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 768700000274 UvrD/REP helicase; Region: UvrD-helicase; cl14126 768700000275 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 768700000276 motif 1; other site 768700000277 active site 768700000278 motif 2; other site 768700000279 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 768700000280 motif 3; other site 768700000281 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 768700000282 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 768700000283 Ligand Binding Site [chemical binding]; other site 768700000284 Ligase N family; Region: LIGANc; smart00532 768700000285 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 768700000286 nucleotide binding pocket [chemical binding]; other site 768700000287 K-X-D-G motif; other site 768700000288 catalytic site [active] 768700000289 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 768700000290 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 768700000291 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318 768700000292 putative dimer interface [polypeptide binding]; other site 768700000293 putative anticodon binding site; other site 768700000294 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768700000295 motif 1; other site 768700000296 dimer interface [polypeptide binding]; other site 768700000297 active site 768700000298 motif 2; other site 768700000299 motif 3; other site 768700000300 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 768700000301 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 768700000302 Class I ribonucleotide reductase; Region: RNR_I; cd01679 768700000303 active site 768700000304 dimer interface [polypeptide binding]; other site 768700000305 catalytic residues [active] 768700000306 effector binding site; other site 768700000307 R2 peptide binding site; other site 768700000308 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768700000309 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 768700000310 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 768700000311 dimer interface [polypeptide binding]; other site 768700000312 putative radical transfer pathway; other site 768700000313 diiron center [ion binding]; other site 768700000314 tyrosyl radical; other site 768700000315 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 768700000316 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 768700000317 putative active site [active] 768700000318 catalytic residue [active] 768700000319 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768700000320 active site 768700000321 putative 5' ssDNA interaction site; other site 768700000322 metal binding site 3; metal-binding site 768700000323 metal binding site 1 [ion binding]; metal-binding site 768700000324 metal binding site 2 [ion binding]; metal-binding site 768700000325 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768700000326 putative DNA binding site [nucleotide binding]; other site 768700000327 putative metal binding site [ion binding]; other site 768700000328 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 768700000329 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 768700000330 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 768700000331 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 768700000332 dimer interface [polypeptide binding]; other site 768700000333 putative anticodon binding site; other site 768700000334 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768700000335 motif 1; other site 768700000336 dimer interface [polypeptide binding]; other site 768700000337 active site 768700000338 motif 2; other site 768700000339 motif 3; other site 768700000340 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 768700000341 conserved cys residue [active] 768700000342 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 768700000343 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 768700000344 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 768700000345 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 768700000346 active site 768700000347 (T/H)XGH motif; other site 768700000348 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 768700000349 rRNA interaction site [nucleotide binding]; other site 768700000350 S8 interaction site; other site 768700000351 putative laminin-1 binding site; other site 768700000352 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 768700000353 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 768700000354 NusA N-terminal domain; Region: NusA_N; pfam08529 768700000355 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 768700000356 G-X-X-G motif; other site 768700000357 translation initiation factor IF-2; Region: IF-2; TIGR00487 768700000358 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 768700000359 G1 box; other site 768700000360 putative GEF interaction site [polypeptide binding]; other site 768700000361 GTP/Mg2+ binding site [chemical binding]; other site 768700000362 Switch I region; other site 768700000363 G2 box; other site 768700000364 G3 box; other site 768700000365 Switch II region; other site 768700000366 G4 box; other site 768700000367 G5 box; other site 768700000368 IF2_IF5B_II: This family represents the domain II of prokaryotic Initiation Factor 2 (IF2) and its archeal and eukaryotic homologue aeIF5B. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2...; Region: IF2_IF5B_II; cd03701 768700000369 Translation-initiation factor 2; Region: IF-2; pfam11987 768700000370 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 768700000371 Ribosome-binding factor A; Region: RBFA; cl00542 768700000372 GTP1/OBG; Region: GTP1_OBG; pfam01018 768700000373 CTP synthetase; Validated; Region: pyrG; PRK05380 768700000374 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 768700000375 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 768700000376 active site 768700000377 putative oxyanion hole; other site 768700000378 catalytic triad [active] 768700000379 histidyl-tRNA synthetase; Region: hisS; TIGR00442 768700000380 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 768700000381 dimer interface [polypeptide binding]; other site 768700000382 motif 1; other site 768700000383 active site 768700000384 motif 2; other site 768700000385 motif 3; other site 768700000386 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 768700000387 anticodon binding site; other site 768700000388 Aspartyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AspS; COG0173 768700000389 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 768700000390 Dimer interface [polypeptide binding]; other site 768700000391 anticodon binding site; other site 768700000392 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768700000393 motif 1; other site 768700000394 dimer interface [polypeptide binding]; other site 768700000395 active site 768700000396 motif 2; other site 768700000397 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768700000398 active site 768700000399 motif 3; other site 768700000400 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 768700000401 HIGH motif; other site 768700000402 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768700000403 active site 768700000404 KMSKS motif; other site 768700000405 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 768700000406 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 768700000407 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 768700000408 DHH family; Region: DHH; pfam01368 768700000409 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768700000410 type IV pilin biogenesis protein; Provisional; Region: PRK10573 768700000411 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 768700000412 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768700000413 active site 768700000414 HIGH motif; other site 768700000415 nucleotide binding site [chemical binding]; other site 768700000416 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768700000417 active site 768700000418 KMSKS motif; other site 768700000419 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 768700000420 anticodon binding site; other site 768700000421 tRNA binding surface [nucleotide binding]; other site 768700000422 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 768700000423 catalytic site [active] 768700000424 G-X2-G-X-G-K; other site 768700000425 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 768700000426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 768700000427 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 768700000428 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 768700000429 ABC-ATPase subunit interface; other site 768700000430 dimer interface [polypeptide binding]; other site 768700000431 putative PBP binding regions; other site 768700000432 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 768700000433 ABC-ATPase subunit interface; other site 768700000434 dimer interface [polypeptide binding]; other site 768700000435 putative PBP binding regions; other site 768700000436 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 768700000437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 768700000438 Walker A/P-loop; other site 768700000439 ATP binding site [chemical binding]; other site 768700000440 Q-loop/lid; other site 768700000441 ABC transporter signature motif; other site 768700000442 Walker B; other site 768700000443 D-loop; other site 768700000444 H-loop/switch region; other site 768700000445 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768700000446 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768700000447 Walker A/P-loop; other site 768700000448 ATP binding site [chemical binding]; other site 768700000449 Q-loop/lid; other site 768700000450 ABC transporter signature motif; other site 768700000451 Walker B; other site 768700000452 D-loop; other site 768700000453 H-loop/switch region; other site 768700000454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768700000455 Elongation factor TS; Region: EF_TS; pfam00889 768700000456 elongation factor Ts; Provisional; Region: tsf; PRK09377 768700000457 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 768700000458 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 768700000459 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 768700000460 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 768700000461 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768700000462 HIGH motif; other site 768700000463 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768700000464 active site 768700000465 KMSKS motif; other site 768700000466 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 768700000467 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000468 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000469 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000470 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768700000471 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 768700000472 cofactor binding site; other site 768700000473 DNA binding site [nucleotide binding] 768700000474 substrate interaction site [chemical binding]; other site 768700000475 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13631 768700000476 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 768700000477 Walker A/P-loop; other site 768700000478 ATP binding site [chemical binding]; other site 768700000479 Q-loop/lid; other site 768700000480 ABC transporter signature motif; other site 768700000481 Walker B; other site 768700000482 D-loop; other site 768700000483 H-loop/switch region; other site 768700000484 Cobalt transport protein; Region: CbiQ; cl00463 768700000485 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 768700000486 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 768700000487 Walker A/P-loop; other site 768700000488 ATP binding site [chemical binding]; other site 768700000489 Q-loop/lid; other site 768700000490 ABC transporter signature motif; other site 768700000491 Walker B; other site 768700000492 D-loop; other site 768700000493 H-loop/switch region; other site 768700000494 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 768700000495 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 768700000496 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 768700000497 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 768700000498 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768700000499 RNA binding surface [nucleotide binding]; other site 768700000500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 768700000501 DNA polymerase III PolC; Validated; Region: polC; PRK00448 768700000502 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 768700000503 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768700000504 active site 768700000505 substrate binding site [chemical binding]; other site 768700000506 catalytic site [active] 768700000507 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 768700000508 Recombination protein U; Region: RecU; cl01314 768700000509 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 768700000510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 768700000511 MraZ protein; Region: MraZ; pfam02381 768700000512 cell division protein MraZ; Reviewed; Region: PRK00326 768700000513 MraZ protein; Region: MraZ; pfam02381 768700000514 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 768700000515 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 768700000516 active site 768700000517 catalytic tetrad [active] 768700000518 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 768700000519 Found in ATP-dependent protease La (LON); Region: LON; cl01056 768700000520 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 768700000521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 768700000522 Walker A motif; other site 768700000523 ATP binding site [chemical binding]; other site 768700000524 Walker B motif; other site 768700000525 arginine finger; other site 768700000526 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768700000527 Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in bacteria, P0 in eukaryotes, and L10e in archaea, as well as uncharacterized P0-like eukaryotic proteins. In all three kingdoms, L10 forms a tight complex with...; Region: Ribosomal_L10_P0; cl00376 768700000528 23S rRNA interface [nucleotide binding]; other site 768700000529 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 768700000530 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 768700000531 core dimer interface [polypeptide binding]; other site 768700000532 L10 interface [polypeptide binding]; other site 768700000533 L11 interface [polypeptide binding]; other site 768700000534 putative EF-Tu interaction site [polypeptide binding]; other site 768700000535 putative EF-G interaction site [polypeptide binding]; other site 768700000536 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 768700000537 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 768700000538 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 768700000539 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 768700000540 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 768700000541 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 768700000542 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 768700000543 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 768700000544 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 768700000545 putative translocon binding site; other site 768700000546 protein-rRNA interface [nucleotide binding]; other site 768700000547 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 768700000548 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 768700000549 G-X-X-G motif; other site 768700000550 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 768700000551 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 768700000552 23S rRNA interface [nucleotide binding]; other site 768700000553 5S rRNA interface [nucleotide binding]; other site 768700000554 putative antibiotic binding site [chemical binding]; other site 768700000555 L25 interface [polypeptide binding]; other site 768700000556 L27 interface [polypeptide binding]; other site 768700000557 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 768700000558 23S rRNA interface [nucleotide binding]; other site 768700000559 putative translocon interaction site; other site 768700000560 signal recognition particle (SRP54) interaction site; other site 768700000561 L23 interface [polypeptide binding]; other site 768700000562 trigger factor interaction site; other site 768700000563 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 768700000564 KOW motif; Region: KOW; cl00354 768700000565 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 768700000566 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 768700000567 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 768700000568 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 768700000569 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 768700000570 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 768700000571 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768700000572 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cl00379 768700000573 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 768700000574 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 768700000575 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 768700000576 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 768700000577 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 768700000578 SecY translocase; Region: SecY; pfam00344 768700000579 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 768700000580 Adenylate kinase; Region: ADK; pfam00406 768700000581 AMP-binding site [chemical binding]; other site 768700000582 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 768700000583 methionine aminopeptidase; Reviewed; Region: PRK07281 768700000584 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768700000585 active site 768700000586 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 768700000587 RNA binding site [nucleotide binding]; other site 768700000588 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 768700000589 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 768700000590 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 768700000591 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 768700000592 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 768700000593 alphaNTD homodimer interface [polypeptide binding]; other site 768700000594 alphaNTD - beta interaction site [polypeptide binding]; other site 768700000595 alphaNTD - beta' interaction site [polypeptide binding]; other site 768700000596 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 768700000597 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 768700000598 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 768700000599 domain; Region: GreA_GreB_N; pfam03449 768700000600 C-term; Region: GreA_GreB; pfam01272 768700000601 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 768700000602 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 768700000603 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768700000604 dimerization domain swap beta strand [polypeptide binding]; other site 768700000605 regulatory protein interface [polypeptide binding]; other site 768700000606 active site 768700000607 regulatory phosphorylation site [posttranslational modification]; other site 768700000608 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 768700000609 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 768700000610 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 768700000611 Walker A/P-loop; other site 768700000612 ATP binding site [chemical binding]; other site 768700000613 Q-loop/lid; other site 768700000614 ABC transporter signature motif; other site 768700000615 Walker B; other site 768700000616 D-loop; other site 768700000617 H-loop/switch region; other site 768700000618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 768700000619 dimer interface [polypeptide binding]; other site 768700000620 conserved gate region; other site 768700000621 ABC-ATPase subunit interface; other site 768700000622 MgtE intracellular N domain; Region: MgtE_N; cl15244 768700000623 FOG: CBS domain [General function prediction only]; Region: COG0517 768700000624 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 768700000625 Divalent cation transporter; Region: MgtE; cl00786 768700000626 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 768700000627 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 768700000628 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 768700000629 nucleotide binding site/active site [active] 768700000630 HIT family signature motif; other site 768700000631 catalytic residue [active] 768700000632 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 768700000633 16S rRNA interaction site [nucleotide binding]; other site 768700000634 streptomycin interaction site [chemical binding]; other site 768700000635 23S rRNA interaction site [nucleotide binding]; other site 768700000636 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 768700000637 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 768700000638 elongation factor G; Reviewed; Region: PRK00007 768700000639 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 768700000640 G1 box; other site 768700000641 putative GEF interaction site [polypeptide binding]; other site 768700000642 GTP/Mg2+ binding site [chemical binding]; other site 768700000643 Switch I region; other site 768700000644 G2 box; other site 768700000645 G3 box; other site 768700000646 Switch II region; other site 768700000647 G4 box; other site 768700000648 G5 box; other site 768700000649 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 768700000650 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 768700000651 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 768700000652 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 768700000653 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 768700000654 HSP70 interaction site [polypeptide binding]; other site 768700000655 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 768700000656 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 768700000657 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 768700000658 dimer interface [polypeptide binding]; other site 768700000659 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 768700000660 hypothetical protein; Provisional; Region: PRK08185 768700000661 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 768700000662 intersubunit interface [polypeptide binding]; other site 768700000663 active site 768700000664 zinc binding site [ion binding]; other site 768700000665 Na+ binding site [ion binding]; other site 768700000666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768700000667 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 768700000668 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 768700000669 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 768700000670 Cation transport protein; Region: TrkH; cl10514 768700000671 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 768700000672 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 768700000673 active site 768700000674 GMP synthase; Reviewed; Region: guaA; PRK00074 768700000675 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 768700000676 conserved cys residue [active] 768700000677 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 768700000678 ATP Binding subdomain [chemical binding]; other site 768700000679 Ligand Binding sites [chemical binding]; other site 768700000680 Dimerization subdomain; other site 768700000681 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 768700000682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 768700000683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 768700000684 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768700000685 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768700000686 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 768700000687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768700000688 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 768700000689 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 768700000690 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768700000691 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 768700000692 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 768700000693 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 768700000694 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 768700000695 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 768700000696 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 768700000697 IHF - DNA interface [nucleotide binding]; other site 768700000698 IHF dimer interface [polypeptide binding]; other site 768700000699 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cl00257 768700000700 IHF dimer interface [polypeptide binding]; other site 768700000701 IHF - DNA interface [nucleotide binding]; other site 768700000702 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 768700000703 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 768700000704 G1 box; other site 768700000705 GTP/Mg2+ binding site [chemical binding]; other site 768700000706 G2 box; other site 768700000707 Switch I region; other site 768700000708 G3 box; other site 768700000709 Switch II region; other site 768700000710 G4 box; other site 768700000711 G5 box; other site 768700000712 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 768700000713 G1 box; other site 768700000714 GTP/Mg2+ binding site [chemical binding]; other site 768700000715 Switch I region; other site 768700000716 G2 box; other site 768700000717 G3 box; other site 768700000718 Switch II region; other site 768700000719 G4 box; other site 768700000720 G5 box; other site 768700000721 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 768700000722 active site 768700000723 substrate binding site [chemical binding]; other site 768700000724 ATP binding site [chemical binding]; other site 768700000725 dimer interface [polypeptide binding]; other site 768700000726 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 768700000727 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768700000728 active site 768700000729 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 768700000730 GTP/Mg2+ binding site [chemical binding]; other site 768700000731 G4 box; other site 768700000732 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 768700000733 G1 box; other site 768700000734 Switch I region; other site 768700000735 G2 box; other site 768700000736 G3 box; other site 768700000737 Switch II region; other site 768700000738 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cl00240 768700000739 hinge region; other site 768700000740 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 768700000741 nucleotide binding site [chemical binding]; other site 768700000742 substrate binding site [chemical binding]; other site 768700000743 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 768700000744 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768700000745 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 768700000746 alpha subunit interaction interface [polypeptide binding]; other site 768700000747 Walker A motif; other site 768700000748 ATP binding site [chemical binding]; other site 768700000749 Walker B motif; other site 768700000750 inhibitor binding site; inhibition site 768700000751 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768700000752 Protein of unknown function (DUF402); Region: DUF402; cl00979 768700000753 ATP synthase; Region: ATP-synt; cl00365 768700000754 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 768700000755 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 768700000756 Walker A motif; other site 768700000757 ATP binding site [chemical binding]; other site 768700000758 Walker B motif; other site 768700000759 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 768700000760 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 768700000761 ATP synthase subunit C; Region: ATP-synt_C; cl00466 768700000762 ATP synthase A chain; Region: ATP-synt_A; cl00413 768700000763 Competence protein; Region: Competence; cl00471 768700000764 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 768700000765 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768700000766 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768700000767 active site 768700000768 KMSKS motif; other site 768700000769 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 768700000770 tRNA binding surface [nucleotide binding]; other site 768700000771 anticodon binding site; other site 768700000772 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 768700000773 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 768700000774 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 768700000775 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 768700000776 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 768700000777 active site 768700000778 HIGH motif; other site 768700000779 KMSK motif region; other site 768700000780 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 768700000781 tRNA binding surface [nucleotide binding]; other site 768700000782 anticodon binding site; other site 768700000783 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 768700000784 RNA/DNA hybrid binding site [nucleotide binding]; other site 768700000785 active site 768700000786 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 768700000787 23S rRNA interface [nucleotide binding]; other site 768700000788 L3 interface [polypeptide binding]; other site 768700000789 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 768700000790 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 768700000791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768700000792 Domain of unknown function (DUF3498); Region: DUF3498; pfam12004 768700000793 Protein of unknown function (DUF342); Region: DUF342; pfam03961 768700000794 threonine synthase; Validated; Region: PRK05638 768700000795 ATP synthase subunit C; Region: ATP-synt_C; cl00466 768700000796 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 768700000797 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 768700000798 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 768700000799 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768700000800 RPB11 interaction site [polypeptide binding]; other site 768700000801 RPB3 interaction site [polypeptide binding]; other site 768700000802 RPB12 interaction site [polypeptide binding]; other site 768700000803 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 768700000804 RPB1 interaction site [polypeptide binding]; other site 768700000805 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 768700000806 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 768700000807 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 768700000808 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 768700000809 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 768700000810 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768700000811 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 768700000812 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 768700000813 DNA binding site [nucleotide binding] 768700000814 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 768700000815 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 768700000816 domain interfaces; other site 768700000817 active site 768700000818 6-phosphofructokinase; Provisional; Region: PRK03202 768700000819 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 768700000820 active site 768700000821 ADP/pyrophosphate binding site [chemical binding]; other site 768700000822 dimerization interface [polypeptide binding]; other site 768700000823 allosteric effector site; other site 768700000824 fructose-1,6-bisphosphate binding site; other site 768700000825 enolase; Provisional; Region: eno; PRK00077 768700000826 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 768700000827 dimer interface [polypeptide binding]; other site 768700000828 metal binding site [ion binding]; metal-binding site 768700000829 substrate binding pocket [chemical binding]; other site 768700000830 ribonuclease R; Region: RNase_R; TIGR02063 768700000831 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 768700000832 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 768700000833 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 768700000834 tetramer interface [polypeptide binding]; other site 768700000835 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 768700000836 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 768700000837 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 768700000838 translation elongation factor P; Region: efp; TIGR00038 768700000839 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 768700000840 RNA binding site [nucleotide binding]; other site 768700000841 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 768700000842 RNA binding site [nucleotide binding]; other site 768700000843 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 768700000844 23S rRNA binding site [nucleotide binding]; other site 768700000845 L21 binding site [polypeptide binding]; other site 768700000846 L13 binding site [polypeptide binding]; other site 768700000847 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 768700000848 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 768700000849 preprotein translocase, SecA subunit; Region: secA; TIGR00963 768700000850 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 768700000851 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 768700000852 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 768700000853 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 768700000854 dimer interface [polypeptide binding]; other site 768700000855 substrate binding site [chemical binding]; other site 768700000856 metal binding sites [ion binding]; metal-binding site 768700000857 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768700000858 catalytic residues [active] 768700000859 aspartyl/glutamyl-tRNA amidotransferase subunit C-like protein; Provisional; Region: PRK12821 768700000860 hypothetical protein; Provisional; Region: PRK09609 768700000861 glycyl-tRNA synthetase; Provisional; Region: PRK04173 768700000862 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768700000863 motif 1; other site 768700000864 dimer interface [polypeptide binding]; other site 768700000865 active site 768700000866 motif 2; other site 768700000867 motif 3; other site 768700000868 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266 768700000869 anticodon binding site; other site 768700000870 CHC2 zinc finger; Region: zf-CHC2; cl02597 768700000871 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 768700000872 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 768700000873 active site 768700000874 metal binding site [ion binding]; metal-binding site 768700000875 interdomain interaction site; other site 768700000876 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 768700000877 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 768700000878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 768700000879 Walker A motif; other site 768700000880 ATP binding site [chemical binding]; other site 768700000881 Walker B motif; other site 768700000882 arginine finger; other site 768700000883 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 768700000884 Domain of unknown function DUF31; Region: DUF31; pfam01732 768700000885 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000886 HsdM N-terminal domain; Region: HsdM_N; pfam12161 768700000887 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 768700000888 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 768700000889 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 768700000890 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000891 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000892 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000893 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000894 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000895 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 768700000896 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 768700000897 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 768700000898 ATP binding site [chemical binding]; other site 768700000899 putative Mg++ binding site [ion binding]; other site 768700000900 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000901 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768700000902 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 768700000903 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 768700000904 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 768700000905 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 768700000906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768700000907 ATP binding site [chemical binding]; other site 768700000908 putative Mg++ binding site [ion binding]; other site 768700000909 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 768700000910 interface (dimer of trimers) [polypeptide binding]; other site 768700000911 Substrate-binding/catalytic site; other site 768700000912 Zn-binding sites [ion binding]; other site 768700000913 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768700000914 motif 1; other site 768700000915 dimer interface [polypeptide binding]; other site 768700000916 active site 768700000917 motif 2; other site 768700000918 motif 3; other site 768700000919 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266 768700000920 anticodon binding site; other site 768700000921 oligoendopeptidase F; Region: pepF; TIGR00181 768700000922 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 768700000923 Zn binding site [ion binding]; other site 768700000924 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 768700000925 thymidylate kinase; Validated; Region: tmk; PRK00698 768700000926 TMP-binding site; other site 768700000927 ATP-binding site [chemical binding]; other site 768700000928 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 768700000929 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 768700000930 Walker A motif; other site 768700000931 ATP binding site [chemical binding]; other site 768700000932 Walker B motif; other site 768700000933 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768700000934 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 768700000935 active site 768700000936 nucleotide binding site [chemical binding]; other site 768700000937 HIGH motif; other site 768700000938 KMSKS motif; other site 768700000939 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 768700000940 tRNA binding surface [nucleotide binding]; other site 768700000941 anticodon binding site; other site 768700000942 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 768700000943 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 768700000944 HPr kinase/phosphorylase; Provisional; Region: PRK05428 768700000945 DRTGG domain; Region: DRTGG; cl12147 768700000946 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 768700000947 Hpr binding site; other site 768700000948 active site 768700000949 homohexamer subunit interaction site [polypeptide binding]; other site 768700000950 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 768700000951 substrate binding site [chemical binding]; other site 768700000952 hinge regions; other site 768700000953 ADP binding site [chemical binding]; other site 768700000954 catalytic site [active] 768700000955 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 768700000956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768700000957 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768700000958 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768700000959 RNB domain; Region: RNB; pfam00773 768700000960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 768700000961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 768700000962 S-adenosylmethionine binding site [chemical binding]; other site 768700000963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 768700000964 DpnII restriction endonuclease; Region: DpnII; pfam04556 768700000965 endonuclease IV; Provisional; Region: PRK01060 768700000966 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 768700000967 AP (apurinic/apyrimidinic) site pocket; other site 768700000968 DNA interaction; other site 768700000969 Metal-binding active site; metal-binding site 768700000970 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 768700000971 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768700000972 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 768700000973 putative active site [active] 768700000974 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 768700000975 Walker A/P-loop; other site 768700000976 ATP binding site [chemical binding]; other site 768700000977 Q-loop/lid; other site 768700000978 ABC transporter signature motif; other site 768700000979 Walker B; other site 768700000980 D-loop; other site 768700000981 H-loop/switch region; other site 768700000982 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 768700000983 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 768700000984 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 768700000985 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 768700000986 active site turn [active] 768700000987 phosphorylation site [posttranslational modification] 768700000988 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 768700000989 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 768700000990 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768700000991 active site 768700000992 metal binding site [ion binding]; metal-binding site 768700000993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 768700000994 peptide chain release factor 1; Validated; Region: prfA; PRK00591 768700000995 RF-1 domain; Region: RF-1; cl02875 768700000996 RF-1 domain; Region: RF-1; cl02875 768700000997 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 768700000998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 768700000999 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 768700001000 Walker A motif; other site 768700001001 ATP binding site [chemical binding]; other site 768700001002 Walker B motif; other site 768700001003 DNA polymerase III subunit delta'; Validated; Region: PRK09112 768700001004 arginine finger; other site 768700001005 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 768700001006 DNA topoisomerase I; Validated; Region: PRK05582 768700001007 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 768700001008 active site 768700001009 metal binding site [ion binding]; metal-binding site 768700001010 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 768700001011 domain I; other site 768700001012 DNA binding groove [nucleotide binding] 768700001013 phosphate binding site [ion binding]; other site 768700001014 domain II; other site 768700001015 domain III; other site 768700001016 nucleotide binding site [chemical binding]; other site 768700001017 catalytic site [active] 768700001018 domain IV; other site 768700001019 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 768700001020 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 768700001021 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 768700001022 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 768700001023 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 768700001024 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 768700001025 seryl-tRNA synthetase; Provisional; Region: PRK05431 768700001026 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 768700001027 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768700001028 motif 1; other site 768700001029 dimer interface [polypeptide binding]; other site 768700001030 active site 768700001031 motif 2; other site 768700001032 motif 3; other site 768700001033 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 768700001034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 768700001035 Walker A motif; other site 768700001036 ATP binding site [chemical binding]; other site 768700001037 Walker B motif; other site 768700001038 arginine finger; other site 768700001039 Peptidase family M41; Region: Peptidase_M41; pfam01434 768700001040 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 768700001041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 768700001042 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 768700001043 Ribonuclease P; Region: Ribonuclease_P; cl00457 768700001044 Ribosomal protein L34; Region: Ribosomal_L34; cl00370