-- dump date 20120504_153832 -- class Genbank::misc_feature -- table misc_feature_note -- id note 434131000001 ParB-like partition proteins; Region: parB_part; TIGR00180 434131000002 ParB-like nuclease domain; Region: ParBc; cl02129 434131000003 KorB domain; Region: KorB; pfam08535 434131000004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 434131000005 dimer interface [polypeptide binding]; other site 434131000006 phosphorylation site [posttranslational modification] 434131000007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 434131000008 ATP binding site [chemical binding]; other site 434131000009 Mg2+ binding site [ion binding]; other site 434131000010 G-X-G motif; other site 434131000011 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 434131000012 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 434131000013 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 434131000014 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 434131000015 Phage-related protein [Function unknown]; Region: COG4695; cl01923 434131000016 Phage portal protein; Region: Phage_portal; pfam04860 434131000017 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 434131000018 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 434131000019 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 434131000020 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 434131000021 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 434131000022 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 434131000023 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 434131000024 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 434131000025 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 434131000026 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 434131000027 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 434131000028 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 434131000029 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 434131000030 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 434131000031 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 434131000032 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 434131000033 dimerization interface 3.5A [polypeptide binding]; other site 434131000034 active site 434131000035 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 434131000036 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 434131000037 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 434131000038 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 434131000039 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 434131000040 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 434131000041 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 434131000042 dimerization interface [polypeptide binding]; other site 434131000043 putative ATP binding site [chemical binding]; other site 434131000044 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 434131000045 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 434131000046 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 434131000047 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 434131000048 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 434131000049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 434131000050 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 434131000051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 434131000052 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 434131000053 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 434131000054 active site 434131000055 nucleotide binding site [chemical binding]; other site 434131000056 HIGH motif; other site 434131000057 KMSKS motif; other site 434131000058 Riboflavin kinase; Region: Flavokinase; cl03312 434131000059 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 434131000060 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 434131000061 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000062 Walker A/P-loop; other site 434131000063 ATP binding site [chemical binding]; other site 434131000064 Q-loop/lid; other site 434131000065 ABC transporter signature motif; other site 434131000066 Walker B; other site 434131000067 D-loop; other site 434131000068 H-loop/switch region; other site 434131000069 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 434131000070 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 434131000071 NAD binding site [chemical binding]; other site 434131000072 homotetramer interface [polypeptide binding]; other site 434131000073 homodimer interface [polypeptide binding]; other site 434131000074 substrate binding site [chemical binding]; other site 434131000075 active site 434131000076 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 434131000077 thiS-thiF/thiG interaction site; other site 434131000078 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 434131000079 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 434131000080 trimer interface [polypeptide binding]; other site 434131000081 putative metal binding site [ion binding]; other site 434131000082 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 434131000083 Iron-sulfur protein interface; other site 434131000084 proximal quinone binding site [chemical binding]; other site 434131000085 SdhD (CybS) interface [polypeptide binding]; other site 434131000086 proximal heme binding site [chemical binding]; other site 434131000087 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 434131000088 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 434131000089 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 434131000090 active site 434131000091 HIGH motif; other site 434131000092 KMSK motif region; other site 434131000093 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 434131000094 tRNA binding surface [nucleotide binding]; other site 434131000095 anticodon binding site; other site 434131000096 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 434131000097 NADH dehydrogenase subunit G; Validated; Region: PRK09130 434131000098 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 434131000099 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 434131000100 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 434131000101 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 434131000102 NADH dehydrogenase; Region: NADHdh; cl00469 434131000103 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 434131000104 BON domain; Region: BON; cl02771 434131000105 BON domain; Region: BON; cl02771 434131000106 fumarate hydratase; Reviewed; Region: fumC; PRK00485 434131000107 Class II fumarases; Region: Fumarase_classII; cd01362 434131000108 active site 434131000109 tetramer interface [polypeptide binding]; other site 434131000110 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 434131000111 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 434131000112 archaeal exosome-like complex exonuclease 1; Region: ECX1; TIGR02065 434131000113 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 434131000114 RNase E interface [polypeptide binding]; other site 434131000115 trimer interface [polypeptide binding]; other site 434131000116 active site 434131000117 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 434131000118 putative nucleic acid binding region [nucleotide binding]; other site 434131000119 G-X-X-G motif; other site 434131000120 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 434131000121 RNA binding site [nucleotide binding]; other site 434131000122 domain interface; other site 434131000123 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 434131000124 16S/18S rRNA binding site [nucleotide binding]; other site 434131000125 S13e-L30e interaction site [polypeptide binding]; other site 434131000126 25S rRNA binding site [nucleotide binding]; other site 434131000127 adenylosuccinate lyase; Provisional; Region: PRK07492 434131000128 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 434131000129 tetramer interface [polypeptide binding]; other site 434131000130 active site 434131000131 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 434131000132 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 434131000133 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 434131000134 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 434131000135 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 434131000136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 434131000137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 434131000138 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 434131000139 putative substrate translocation pore; other site 434131000140 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cl01321 434131000141 transcription termination factor Rho; Provisional; Region: rho; PRK09376 434131000142 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 434131000143 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 434131000144 RNA binding site [nucleotide binding]; other site 434131000145 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 434131000146 multimer interface [polypeptide binding]; other site 434131000147 Walker A motif; other site 434131000148 ATP binding site [chemical binding]; other site 434131000149 Walker B motif; other site 434131000150 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 434131000151 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 434131000152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 434131000153 Walker A motif; other site 434131000154 ATP binding site [chemical binding]; other site 434131000155 Walker B motif; other site 434131000156 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 434131000157 IncA protein; Region: IncA; pfam04156 434131000158 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 434131000159 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 434131000160 GatB domain; Region: GatB_Yqey; cl11497 434131000161 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 434131000162 nucleoside/Zn binding site; other site 434131000163 dimer interface [polypeptide binding]; other site 434131000164 catalytic motif [active] 434131000165 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 434131000166 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 434131000167 putative active site [active] 434131000168 substrate binding site [chemical binding]; other site 434131000169 putative cosubstrate binding site; other site 434131000170 catalytic site [active] 434131000171 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 434131000172 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 434131000173 homodimer interface [polypeptide binding]; other site 434131000174 NAD synthase; Region: NAD_synthase; pfam02540 434131000175 NAD binding pocket [chemical binding]; other site 434131000176 ATP binding pocket [chemical binding]; other site 434131000177 Mg binding site [ion binding]; other site 434131000178 active-site loop [active] 434131000179 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 434131000180 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 434131000181 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 434131000182 RNA binding site [nucleotide binding]; other site 434131000183 active site 434131000184 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 434131000185 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 434131000186 Clp amino terminal domain; Region: Clp_N; pfam02861 434131000187 Clp amino terminal domain; Region: Clp_N; pfam02861 434131000188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 434131000189 Walker A motif; other site 434131000190 ATP binding site [chemical binding]; other site 434131000191 Walker B motif; other site 434131000192 arginine finger; other site 434131000193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 434131000194 Walker A motif; other site 434131000195 ATP binding site [chemical binding]; other site 434131000196 Walker B motif; other site 434131000197 arginine finger; other site 434131000198 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 434131000199 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 434131000200 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 434131000201 homodimer interface [polypeptide binding]; other site 434131000202 oligonucleotide binding site [chemical binding]; other site 434131000203 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 434131000204 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 434131000205 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 434131000206 dimerization interface [polypeptide binding]; other site 434131000207 active site 434131000208 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 434131000209 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 434131000210 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 434131000211 Uncharacterized conserved protein [Function unknown]; Region: COG2433 434131000212 RmuC family; Region: RmuC; pfam02646 434131000213 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 434131000214 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 434131000215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131000216 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 434131000217 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 434131000218 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 434131000219 beta subunit interaction interface [polypeptide binding]; other site 434131000220 Walker A motif; other site 434131000221 ATP binding site [chemical binding]; other site 434131000222 Walker B motif; other site 434131000223 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 434131000224 Plant ATP synthase F0; Region: YMF19; cl07975 434131000225 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 434131000226 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 434131000227 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 434131000228 homotrimer interaction site [polypeptide binding]; other site 434131000229 zinc binding site [ion binding]; other site 434131000230 CDP-binding sites; other site 434131000231 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 434131000232 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 434131000233 FtsX-like permease family; Region: FtsX; cl15850 434131000234 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 434131000235 active site 434131000236 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 434131000237 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 434131000238 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 434131000239 putative active site; other site 434131000240 catalytic residue [active] 434131000241 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 434131000242 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 434131000243 active site 434131000244 DNA binding site [nucleotide binding] 434131000245 Int/Topo IB signature motif; other site 434131000246 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 434131000247 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 434131000248 RNA binding surface [nucleotide binding]; other site 434131000249 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 434131000250 active site 434131000251 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 434131000252 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 434131000253 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 434131000254 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 434131000255 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 434131000256 dihydroorotase; Validated; Region: pyrC; PRK09357 434131000257 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 434131000258 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 434131000259 active site 434131000260 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 434131000261 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 434131000262 motif 1; other site 434131000263 active site 434131000264 motif 2; other site 434131000265 motif 3; other site 434131000266 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 434131000267 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 434131000268 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 434131000269 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 434131000270 Thymidylate synthase complementing protein; Region: Thy1; cl03630 434131000271 HflK protein; Region: hflK; TIGR01933 434131000272 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 434131000273 HflC protein; Region: hflC; TIGR01932 434131000274 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 434131000275 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 434131000276 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 434131000277 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 434131000278 protein binding site [polypeptide binding]; other site 434131000279 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 434131000280 protein binding site [polypeptide binding]; other site 434131000281 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 434131000282 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 434131000283 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 434131000284 Smr domain; Region: Smr; cl02619 434131000285 DNA polymerase III subunit beta; Validated; Region: PRK05643 434131000286 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 434131000287 putative DNA binding surface [nucleotide binding]; other site 434131000288 dimer interface [polypeptide binding]; other site 434131000289 beta-clamp/clamp loader binding surface; other site 434131000290 beta-clamp/translesion DNA polymerase binding surface; other site 434131000291 isocitrate dehydrogenase; Region: ICDH_alpha; TIGR02924 434131000292 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 434131000293 Membrane transport protein; Region: Mem_trans; cl09117 434131000294 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 434131000295 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 434131000296 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 434131000297 active site 434131000298 HslU subunit interaction site [polypeptide binding]; other site 434131000299 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 434131000300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 434131000301 Walker A motif; other site 434131000302 ATP binding site [chemical binding]; other site 434131000303 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000304 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 434131000305 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 434131000306 substrate binding site; other site 434131000307 dimer interface; other site 434131000308 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 434131000309 quinone interaction residues [chemical binding]; other site 434131000310 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 434131000311 active site 434131000312 catalytic residues [active] 434131000313 FMN binding site [chemical binding]; other site 434131000314 substrate binding site [chemical binding]; other site 434131000315 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 434131000316 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 434131000317 putative active site [active] 434131000318 Protein of unknown function; Region: DUF3971; pfam13116 434131000319 AsmA-like C-terminal region; Region: AsmA_2; cl15864 434131000320 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 434131000321 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 434131000322 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 434131000323 purine monophosphate binding site [chemical binding]; other site 434131000324 dimer interface [polypeptide binding]; other site 434131000325 putative catalytic residues [active] 434131000326 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 434131000327 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 434131000328 glutathione synthetase; Provisional; Region: PRK05246 434131000329 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 434131000330 ATP-grasp domain; Region: ATP-grasp_4; cl03087 434131000331 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 434131000332 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 434131000333 FMN binding site [chemical binding]; other site 434131000334 substrate binding site [chemical binding]; other site 434131000335 putative catalytic residue [active] 434131000336 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000337 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 434131000338 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 434131000339 Protein export membrane protein; Region: SecD_SecF; cl14618 434131000340 amidophosphoribosyltransferase; Provisional; Region: PRK09123 434131000341 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 434131000342 active site 434131000343 tetramer interface [polypeptide binding]; other site 434131000344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 434131000345 active site 434131000346 translation elongation factor P; Region: efp; TIGR00038 434131000347 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 434131000348 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 434131000349 RNA binding site [nucleotide binding]; other site 434131000350 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 434131000351 RNA binding site [nucleotide binding]; other site 434131000352 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 434131000353 recombination protein F; Reviewed; Region: recF; PRK00064 434131000354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000355 Walker A/P-loop; other site 434131000356 ATP binding site [chemical binding]; other site 434131000357 Q-loop/lid; other site 434131000358 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000359 ABC transporter signature motif; other site 434131000360 Walker B; other site 434131000361 D-loop; other site 434131000362 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 434131000363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 434131000364 S-adenosylmethionine binding site [chemical binding]; other site 434131000365 BolA-like protein; Region: BolA; cl00386 434131000366 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 434131000367 putative GSH binding site [chemical binding]; other site 434131000368 catalytic residues [active] 434131000369 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 434131000370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 434131000371 dimer interface [polypeptide binding]; other site 434131000372 conserved gate region; other site 434131000373 putative PBP binding loops; other site 434131000374 ABC-ATPase subunit interface; other site 434131000375 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 434131000376 primosome assembly protein PriA; Validated; Region: PRK05580 434131000377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 434131000378 ATP binding site [chemical binding]; other site 434131000379 putative Mg++ binding site [ion binding]; other site 434131000380 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000381 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 434131000382 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 434131000383 VirB7 interaction site; other site 434131000384 VirB8 protein; Region: VirB8; cl01500 434131000385 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 434131000386 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 434131000387 dimer interface [polypeptide binding]; other site 434131000388 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 434131000389 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 434131000390 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 434131000391 active site 434131000392 HIGH motif; other site 434131000393 dimer interface [polypeptide binding]; other site 434131000394 KMSKS motif; other site 434131000395 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 434131000396 ribosomal protein L20; Region: rpl20; CHL00068 434131000397 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 434131000398 23S rRNA binding site [nucleotide binding]; other site 434131000399 L21 binding site [polypeptide binding]; other site 434131000400 L13 binding site [polypeptide binding]; other site 434131000401 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 434131000402 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 434131000403 dimer interface [polypeptide binding]; other site 434131000404 motif 1; other site 434131000405 active site 434131000406 motif 2; other site 434131000407 motif 3; other site 434131000408 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 434131000409 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 434131000410 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 434131000411 dimer interface [polypeptide binding]; other site 434131000412 active site 434131000413 glycine-pyridoxal phosphate binding site [chemical binding]; other site 434131000414 folate binding site [chemical binding]; other site 434131000415 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 434131000416 thiamine phosphate binding site [chemical binding]; other site 434131000417 active site 434131000418 pyrophosphate binding site [ion binding]; other site 434131000419 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 434131000420 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 434131000421 ATP-grasp domain; Region: ATP-grasp_4; cl03087 434131000422 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 434131000423 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 434131000424 ATP-grasp domain; Region: ATP-grasp_4; cl03087 434131000425 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 434131000426 IMP binding site; other site 434131000427 dimer interface [polypeptide binding]; other site 434131000428 interdomain contacts; other site 434131000429 partial ornithine binding site; other site 434131000430 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 434131000431 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 434131000432 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 434131000433 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 434131000434 GDP-binding site [chemical binding]; other site 434131000435 ACT binding site; other site 434131000436 IMP binding site; other site 434131000437 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cl00559 434131000438 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 434131000439 catalytic residues [active] 434131000440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131000441 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 434131000442 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 434131000443 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 434131000444 MPN+ (JAMM) motif; other site 434131000445 Zinc-binding site [ion binding]; other site 434131000446 hypothetical protein; Reviewed; Region: PRK00024 434131000447 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 434131000448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 434131000449 non-specific DNA binding site [nucleotide binding]; other site 434131000450 salt bridge; other site 434131000451 sequence-specific DNA binding site [nucleotide binding]; other site 434131000452 preprotein translocase, SecA subunit; Region: secA; TIGR00963 434131000453 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000454 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 434131000455 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 434131000456 Helix-turn-helix domains; Region: HTH; cl00088 434131000457 AIR carboxylase; Region: AIRC; cl00310 434131000458 putative glycoprotease GCP; Region: bact_gcp; TIGR03723 434131000459 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 434131000460 NMT1-like family; Region: NMT1_2; cl15260 434131000461 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 434131000462 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 434131000463 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 434131000464 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 434131000465 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 434131000466 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 434131000467 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 434131000468 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 434131000469 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 434131000470 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 434131000471 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 434131000472 succinyl-CoA synthetase, alpha subunit; Region: sucCoAalpha; TIGR01019 434131000473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131000474 CoA-ligase; Region: Ligase_CoA; cl02894 434131000475 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 434131000476 ATP-grasp domain; Region: ATP-grasp_4; cl03087 434131000477 CoA-ligase; Region: Ligase_CoA; cl02894 434131000478 thiamine-monophosphate kinase; Region: thiL; TIGR01379 434131000479 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 434131000480 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 434131000481 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 434131000482 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 434131000483 Amidase; Region: Amidase; cl11426 434131000484 amidohydrolase, AtzE family; Region: amido_AtzE; TIGR02715 434131000485 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 434131000486 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 434131000487 DnaA N-terminal domain; Region: DnaA_N; pfam11638 434131000488 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 434131000489 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000490 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055 434131000491 aspartate-semialdehyde dehydrogenase (peptidoglycan organisms); Region: asd_B; TIGR01296 434131000492 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 434131000493 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 434131000494 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 434131000495 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 434131000496 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 434131000497 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 434131000498 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 434131000499 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 434131000500 ribosomal protein L2, bacterial/organellar; Region: rplB_bact; TIGR01171 434131000501 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 434131000502 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 434131000503 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 434131000504 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cl00327 434131000505 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 434131000506 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 434131000507 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 434131000508 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cl00353 434131000509 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 434131000510 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 434131000511 ribosomal protein L24, bacterial/organelle; Region: rplX_bact; TIGR01079 434131000512 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 434131000513 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 434131000514 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 434131000515 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 434131000516 ribosomal protein L6, bacterial type; Region: L6_bact; TIGR03654 434131000517 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 434131000518 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cl00379 434131000519 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 434131000520 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 434131000521 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 434131000522 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 434131000523 preprotein translocase, SecY subunit; Region: 3a0501s007; TIGR00967 434131000524 SecY translocase; Region: SecY; pfam00344 434131000525 adenylate kinases; Region: adk; TIGR01351 434131000526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000527 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 434131000528 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 434131000529 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 434131000530 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 434131000531 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 434131000532 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 434131000533 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 434131000534 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 434131000535 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 434131000536 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 434131000537 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cl00559 434131000538 translation initiation factor IF-3; Region: infC; TIGR00168 434131000539 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 434131000540 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 434131000541 threonyl-tRNA synthetase; Region: thrS; TIGR00418 434131000542 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 434131000543 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 434131000544 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 434131000545 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 434131000546 Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991 434131000547 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 434131000548 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 434131000549 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 434131000550 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 434131000551 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 434131000552 Helix-turn-helix domains; Region: HTH; cl00088 434131000553 Rrf2 family protein; Region: rrf2_super; TIGR00738 434131000554 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 434131000555 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 434131000556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 434131000557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 434131000558 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 434131000559 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cl00787 434131000560 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cl00352 434131000561 Glutamate-cysteine ligase; Region: GshA; pfam08886 434131000562 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000563 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 434131000564 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 434131000565 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 434131000566 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 434131000567 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 434131000568 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 434131000569 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 434131000570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 434131000571 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 434131000572 Clp amino terminal domain; Region: Clp_N; pfam02861 434131000573 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000574 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000575 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 434131000576 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 434131000577 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 434131000578 Competence protein; Region: Competence; cl00471 434131000579 Competence protein; Region: Competence; cl00471 434131000580 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 434131000581 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 434131000582 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 434131000583 Preprotein translocase subunit; Region: YajC; cl00806 434131000584 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cl00541 434131000585 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 434131000586 lipoate synthase; Region: lipA; TIGR00510 434131000587 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 434131000588 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 434131000589 inosine-5'-monophosphate dehydrogenase; Region: IMP_dehydrog; TIGR01302 434131000590 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 434131000591 Transporter associated domain; Region: CorC_HlyC; cl08393 434131000592 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 434131000593 4Fe-4S binding domain; Region: Fer4; cl02805 434131000594 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 434131000595 cysteinyl-tRNA synthetase; Region: cysS; TIGR00435 434131000596 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 434131000597 DNA mismatch repair protein MutS; Region: mutS1; TIGR01070 434131000598 MutS domain I; Region: MutS_I; pfam01624 434131000599 MutS domain II; Region: MutS_II; pfam05188 434131000600 MutS family domain IV; Region: MutS_IV; pfam05190 434131000601 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000602 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 434131000603 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 434131000604 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 434131000605 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 434131000606 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 434131000607 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 434131000608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 434131000609 cell division protein FtsZ; Region: ftsZ; TIGR00065 434131000610 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 434131000611 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250 434131000612 tyrosyl-tRNA synthetase; Region: tyrS; TIGR00234 434131000613 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 434131000614 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 434131000615 Ferritin-like domain; Region: Ferritin; pfam00210 434131000616 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 434131000617 ATP-dependent protease La; Region: lon; TIGR00763 434131000618 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000619 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 434131000620 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 434131000621 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 434131000622 glutamine synthetase, type I; Region: GlnA; TIGR00653 434131000623 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 434131000624 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 434131000625 transcriptional regulator NrdR; Region: TIGR00244 434131000626 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 434131000627 ATP cone domain; Region: ATP-cone; pfam03477 434131000628 potential frameshift: common BLAST hit: gi|88608415|ref|YP_506245.1| UvrD/Rep family helicase 434131000629 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 434131000630 Family description; Region: UvrD_C_2; cl15862 434131000631 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000632 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 434131000633 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 434131000634 Tim44-like domain; Region: Tim44; cl09208 434131000635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131000636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 434131000637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 434131000638 Response regulator receiver domain; Region: Response_reg; pfam00072 434131000639 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 434131000640 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 434131000641 pyruvate, phosphate dikinase; Region: pyru_phos_dikin; TIGR01828 434131000642 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 434131000643 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 434131000644 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 434131000645 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 434131000646 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 434131000647 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 434131000648 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 434131000649 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 434131000650 Survival protein SurE; Region: SurE; cl00448 434131000651 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 434131000652 succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup; Region: sdhA_forward; TIGR01816 434131000653 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 434131000654 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 434131000655 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 434131000656 Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240 434131000657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131000658 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 434131000659 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 434131000660 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 434131000661 porphobilinogen deaminase; Region: hemC; TIGR00212 434131000662 Porphobilinogen deaminase, C-terminal domain; Region: Porphobil_deamC; pfam03900 434131000663 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 434131000664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131000665 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 434131000666 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 434131000667 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234 434131000668 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 434131000669 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 434131000670 ATP synthase A chain; Region: ATP-synt_A; cl00413 434131000671 ATP synthase subunit C; Region: ATP-synt_C; cl00466 434131000672 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 434131000673 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 434131000674 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 434131000675 gliding motility-associated protein GldE; Region: GldE; TIGR03520 434131000676 Domain of unknown function DUF21; Region: DUF21; pfam01595 434131000677 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 434131000678 Transporter associated domain; Region: CorC_HlyC; cl08393 434131000679 peptide chain release factor 1; Region: prfA; TIGR00019 434131000680 RF-1 domain; Region: RF-1; cl02875 434131000681 RF-1 domain; Region: RF-1; cl02875 434131000682 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 434131000683 ribosomal protein S1; Region: rpsA; TIGR00717 434131000684 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 434131000685 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 434131000686 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 434131000687 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 434131000688 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 434131000689 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 434131000690 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 434131000691 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 434131000692 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 434131000693 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 434131000694 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 434131000695 potential protein location (hypothetical protein NRI_0391 [Neorickettsia risticii str. Illinois]) that overlaps RNA (tRNA-M) 434131000696 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 434131000697 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 434131000698 comF family protein; Region: comF; TIGR00201 434131000699 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 434131000700 active site 434131000701 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 434131000702 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 434131000703 Protein export membrane protein; Region: SecD_SecF; cl14618 434131000704 potential frameshift: common BLAST hit: gi|88608083|ref|YP_506306.1| malic enzyme 434131000705 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 434131000706 Malic enzyme, N-terminal domain; Region: malic; pfam00390 434131000707 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 434131000708 putative NAD(P) binding site [chemical binding]; other site 434131000709 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 434131000710 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 434131000711 FtsH Extracellular; Region: FtsH_ext; pfam06480 434131000712 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 434131000713 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131000714 Peptidase family M41; Region: Peptidase_M41; pfam01434 434131000715 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 434131000716 B3/4 domain; Region: B3_4; cl11458 434131000717 tRNA synthetase B5 domain; Region: B5; cl08394 434131000718 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 434131000719 Cell division protein FtsA; Region: FtsA; cl11496 434131000720 cell division protein FtsA; Region: ftsA; TIGR01174 434131000721 Cell division protein FtsA; Region: FtsA; cl11496 434131000722 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 434131000723 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 434131000724 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 434131000725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131000726 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 434131000727 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 434131000728 Phosphoglycerate kinase; Region: PGK; pfam00162 434131000729 LytB protein; Region: LYTB; cl00507 434131000730 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 434131000731 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 434131000732 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 434131000733 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: Dxr; TIGR00243 434131000734 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 434131000735 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 434131000736 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 434131000737 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 434131000738 GTP1/OBG; Region: GTP1_OBG; pfam01018 434131000739 Obg GTPase; Region: Obg; cd01898 434131000740 G1 box; other site 434131000741 GTP/Mg2+ binding site [chemical binding]; other site 434131000742 Switch I region; other site 434131000743 G2 box; other site 434131000744 G3 box; other site 434131000745 Switch II region; other site 434131000746 G4 box; other site 434131000747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131000748 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 434131000749 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 434131000750 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 434131000751 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 434131000752 Phosphopantetheine attachment site; Region: PP-binding; cl09936 434131000753 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 434131000754 Beta-ketoacyl synthase, N-terminal domain; Region: ketoacyl-synt; cl09934 434131000755 Beta-ketoacyl synthase, C-terminal domain; Region: Ketoacyl-synt_C; pfam02801 434131000756 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 434131000757 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 434131000758 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 434131000759 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 434131000760 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 434131000761 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 434131000762 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 434131000763 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 434131000764 Recombination protein O N terminal; Region: RecO_N; cl15812 434131000765 Recombination protein O C terminal; Region: RecO_C; pfam02565 434131000766 Stringent starvation protein B; Region: SspB; cl01120 434131000767 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 434131000768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 434131000769 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 434131000770 Restriction endonuclease; Region: Mrr_cat; cl00516 434131000771 MgtE intracellular N domain; Region: MgtE_N; cl15244 434131000772 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 434131000773 Divalent cation transporter; Region: MgtE; cl00786 434131000774 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 434131000775 Phage capsid family; Region: Phage_capsid; pfam05065 434131000776 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 434131000777 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 434131000778 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 434131000779 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 434131000780 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 434131000781 Zinc-finger domain; Region: zf-CHCC; cl01821 434131000782 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 434131000783 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 434131000784 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 434131000785 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 434131000786 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 434131000787 active site 434131000788 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 434131000789 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 434131000790 Cytochrome c; Region: Cytochrom_C; cl11414 434131000791 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 434131000792 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 434131000793 active site 434131000794 substrate binding site [chemical binding]; other site 434131000795 cosubstrate binding site; other site 434131000796 catalytic site [active] 434131000797 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 434131000798 interface (dimer of trimers) [polypeptide binding]; other site 434131000799 Substrate-binding/catalytic site; other site 434131000800 Zn-binding sites [ion binding]; other site 434131000801 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 434131000802 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 434131000803 dimer interface [polypeptide binding]; other site 434131000804 anticodon binding site; other site 434131000805 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 434131000806 homodimer interface [polypeptide binding]; other site 434131000807 motif 1; other site 434131000808 active site 434131000809 motif 2; other site 434131000810 GAD domain; Region: GAD; pfam02938 434131000811 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 434131000812 active site 434131000813 motif 3; other site 434131000814 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 434131000815 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 434131000816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 434131000817 dimer interface [polypeptide binding]; other site 434131000818 conserved gate region; other site 434131000819 putative PBP binding loops; other site 434131000820 ABC-ATPase subunit interface; other site 434131000821 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 434131000822 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 434131000823 Walker A/P-loop; other site 434131000824 ATP binding site [chemical binding]; other site 434131000825 Q-loop/lid; other site 434131000826 ABC transporter signature motif; other site 434131000827 Walker B; other site 434131000828 D-loop; other site 434131000829 H-loop/switch region; other site 434131000830 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 434131000831 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 434131000832 ThiS interaction site; other site 434131000833 putative active site [active] 434131000834 tetramer interface [polypeptide binding]; other site 434131000835 dihydropteroate synthase; Region: DHPS; TIGR01496 434131000836 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 434131000837 substrate binding pocket [chemical binding]; other site 434131000838 dimer interface [polypeptide binding]; other site 434131000839 inhibitor binding site; inhibition site 434131000840 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 434131000841 catalytic center binding site [active] 434131000842 ATP binding site [chemical binding]; other site 434131000843 S-adenosylmethionine synthetase; Validated; Region: PRK05250 434131000844 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 434131000845 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 434131000846 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 434131000847 Helix-turn-helix domains; Region: HTH; cl00088 434131000848 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 434131000849 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 434131000850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 434131000851 Walker A motif; other site 434131000852 ATP binding site [chemical binding]; other site 434131000853 Walker B motif; other site 434131000854 arginine finger; other site 434131000855 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 434131000856 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 434131000857 heat shock protein 90; Provisional; Region: PRK05218 434131000858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 434131000859 ATP binding site [chemical binding]; other site 434131000860 Mg2+ binding site [ion binding]; other site 434131000861 G-X-G motif; other site 434131000862 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 434131000863 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 434131000864 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 434131000865 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 434131000866 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 434131000867 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 434131000868 putative active site [active] 434131000869 catalytic triad [active] 434131000870 putative dimer interface [polypeptide binding]; other site 434131000871 AsmA-like C-terminal region; Region: AsmA_2; cl15864 434131000872 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 434131000873 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 434131000874 catalytic motif [active] 434131000875 Zn binding site [ion binding]; other site 434131000876 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 434131000877 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 434131000878 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 434131000879 nucleotide binding pocket [chemical binding]; other site 434131000880 K-X-D-G motif; other site 434131000881 catalytic site [active] 434131000882 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 434131000883 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 434131000884 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 434131000885 Dimer interface [polypeptide binding]; other site 434131000886 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 434131000887 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 434131000888 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 434131000889 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 434131000890 catalytic site [active] 434131000891 subunit interface [polypeptide binding]; other site 434131000892 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 434131000893 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 434131000894 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 434131000895 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 434131000896 HIGH motif; other site 434131000897 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 434131000898 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 434131000899 active site 434131000900 KMSKS motif; other site 434131000901 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 434131000902 tRNA binding surface [nucleotide binding]; other site 434131000903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 434131000904 non-specific DNA binding site [nucleotide binding]; other site 434131000905 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 434131000906 salt bridge; other site 434131000907 sequence-specific DNA binding site [nucleotide binding]; other site 434131000908 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 434131000909 Catalytic site [active] 434131000910 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 434131000911 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 434131000912 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 434131000913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131000914 response regulator PleD; Reviewed; Region: pleD; PRK09581 434131000915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 434131000916 active site 434131000917 phosphorylation site [posttranslational modification] 434131000918 intermolecular recognition site; other site 434131000919 dimerization interface [polypeptide binding]; other site 434131000920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 434131000921 active site 434131000922 phosphorylation site [posttranslational modification] 434131000923 intermolecular recognition site; other site 434131000924 dimerization interface [polypeptide binding]; other site 434131000925 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 434131000926 metal binding site [ion binding]; metal-binding site 434131000927 active site 434131000928 I-site; other site 434131000929 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 434131000930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131000931 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 434131000932 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 434131000933 active site 434131000934 KMSKS motif; other site 434131000935 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 434131000936 active site 434131000937 HIGH motif; other site 434131000938 nucleotide binding site [chemical binding]; other site 434131000939 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 434131000940 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 434131000941 diiron center [ion binding]; other site 434131000942 putative radical transfer pathway; other site 434131000943 dimer interface [polypeptide binding]; other site 434131000944 tyrosyl radical; other site 434131000945 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 434131000946 NusA N-terminal domain; Region: NusA_N; pfam08529 434131000947 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 434131000948 RNA binding site [nucleotide binding]; other site 434131000949 homodimer interface [polypeptide binding]; other site 434131000950 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 434131000951 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 434131000952 G-X-X-G motif; other site 434131000953 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 434131000954 translation initiation factor IF-2; Region: IF-2; TIGR00487 434131000955 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 434131000956 G1 box; other site 434131000957 putative GEF interaction site [polypeptide binding]; other site 434131000958 GTP/Mg2+ binding site [chemical binding]; other site 434131000959 Switch I region; other site 434131000960 G2 box; other site 434131000961 G3 box; other site 434131000962 Switch II region; other site 434131000963 G4 box; other site 434131000964 G5 box; other site 434131000965 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 434131000966 Translation-initiation factor 2; Region: IF-2; pfam11987 434131000967 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 434131000968 Ribosome-binding factor A; Region: RBFA; cl00542 434131000969 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 434131000970 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 434131000971 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 434131000972 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 434131000973 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 434131000974 active site 434131000975 mce related protein; Region: MCE; pfam02470 434131000976 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534 434131000977 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 434131000978 catalytic site [active] 434131000979 putative active site [active] 434131000980 putative substrate binding site [chemical binding]; other site 434131000981 recombinase A; Provisional; Region: recA; PRK09354 434131000982 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 434131000983 hexamer interface [polypeptide binding]; other site 434131000984 Walker A motif; other site 434131000985 ATP binding site [chemical binding]; other site 434131000986 Walker B motif; other site 434131000987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 434131000988 dimer interface [polypeptide binding]; other site 434131000989 phosphorylation site [posttranslational modification] 434131000990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 434131000991 ATP binding site [chemical binding]; other site 434131000992 Mg2+ binding site [ion binding]; other site 434131000993 G-X-G motif; other site 434131000994 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 434131000995 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 434131000996 chaperone protein DnaJ; Provisional; Region: PRK10767 434131000997 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 434131000998 HSP70 interaction site [polypeptide binding]; other site 434131000999 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 434131001000 substrate binding site [polypeptide binding]; other site 434131001001 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 434131001002 Zn binding sites [ion binding]; other site 434131001003 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 434131001004 dimer interface [polypeptide binding]; other site 434131001005 GTP-binding protein Der; Reviewed; Region: PRK00093 434131001006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131001007 G1 box; other site 434131001008 GTP/Mg2+ binding site [chemical binding]; other site 434131001009 G2 box; other site 434131001010 Switch I region; other site 434131001011 G3 box; other site 434131001012 Switch II region; other site 434131001013 G4 box; other site 434131001014 G5 box; other site 434131001015 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131001016 G1 box; other site 434131001017 GTP/Mg2+ binding site [chemical binding]; other site 434131001018 G2 box; other site 434131001019 Switch I region; other site 434131001020 G3 box; other site 434131001021 Switch II region; other site 434131001022 G4 box; other site 434131001023 G5 box; other site 434131001024 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 434131001025 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 434131001026 HIGH motif; other site 434131001027 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 434131001028 active site 434131001029 KMSKS motif; other site 434131001030 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 434131001031 tRNA binding surface [nucleotide binding]; other site 434131001032 anticodon binding site; other site 434131001033 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 434131001034 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 434131001035 active site 434131001036 signal recognition particle protein; Provisional; Region: PRK10867 434131001037 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 434131001038 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 434131001039 P loop; other site 434131001040 GTP binding site [chemical binding]; other site 434131001041 Signal peptide binding domain; Region: SRP_SPB; pfam02978 434131001042 RDD family; Region: RDD; cl00746 434131001043 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 434131001044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131001045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 434131001046 S-adenosylmethionine binding site [chemical binding]; other site 434131001047 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 434131001048 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 434131001049 FMN binding site [chemical binding]; other site 434131001050 substrate binding site [chemical binding]; other site 434131001051 putative catalytic residue [active] 434131001052 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 434131001053 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 434131001054 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 434131001055 P loop; other site 434131001056 GTP binding site [chemical binding]; other site 434131001057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 434131001058 thymidylate kinase; Validated; Region: tmk; PRK00698 434131001059 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 434131001060 TMP-binding site; other site 434131001061 ATP-binding site [chemical binding]; other site 434131001062 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 434131001063 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 434131001064 E3 interaction surface; other site 434131001065 lipoyl attachment site [posttranslational modification]; other site 434131001066 e3 binding domain; Region: E3_binding; pfam02817 434131001067 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 434131001068 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 434131001069 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 434131001070 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 434131001071 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 434131001072 Cu(I) binding site [ion binding]; other site 434131001073 replicative DNA helicase; Provisional; Region: PRK09165 434131001074 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 434131001075 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 434131001076 Walker A motif; other site 434131001077 ATP binding site [chemical binding]; other site 434131001078 Walker B motif; other site 434131001079 DNA binding loops [nucleotide binding] 434131001080 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 434131001081 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 434131001082 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 434131001083 active site 434131001084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131001085 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 434131001086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 434131001087 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 434131001088 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 434131001089 dimer interface [polypeptide binding]; other site 434131001090 decamer (pentamer of dimers) interface [polypeptide binding]; other site 434131001091 catalytic triad [active] 434131001092 peroxidatic and resolving cysteines [active] 434131001093 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 434131001094 active site 434131001095 multimer interface [polypeptide binding]; other site 434131001096 integral membrane protein MviN; Region: mviN; TIGR01695 434131001097 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 434131001098 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 434131001099 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 434131001100 seryl-tRNA synthetase; Provisional; Region: PRK05431 434131001101 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 434131001102 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 434131001103 dimer interface [polypeptide binding]; other site 434131001104 active site 434131001105 motif 1; other site 434131001106 motif 2; other site 434131001107 motif 3; other site 434131001108 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 434131001109 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131001110 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 434131001111 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 434131001112 RuvA N terminal domain; Region: RuvA_N; pfam01330 434131001113 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 434131001114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 434131001115 Walker A motif; other site 434131001116 ATP binding site [chemical binding]; other site 434131001117 Walker B motif; other site 434131001118 arginine finger; other site 434131001119 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 434131001120 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 434131001121 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 434131001122 TPP-binding site [chemical binding]; other site 434131001123 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 434131001124 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 434131001125 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 434131001126 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 434131001127 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 434131001128 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 434131001129 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 434131001130 RNA binding surface [nucleotide binding]; other site 434131001131 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 434131001132 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 434131001133 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 434131001134 active site 434131001135 ATP synthase; Region: ATP-synt; cl00365 434131001136 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 434131001137 FAD binding domain; Region: FAD_binding_4; pfam01565 434131001138 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 434131001139 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 434131001140 active site 434131001141 DNA topoisomerase I; Validated; Region: PRK06599 434131001142 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 434131001143 active site 434131001144 interdomain interaction site; other site 434131001145 putative metal-binding site [ion binding]; other site 434131001146 nucleotide binding site [chemical binding]; other site 434131001147 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 434131001148 domain I; other site 434131001149 DNA binding groove [nucleotide binding] 434131001150 phosphate binding site [ion binding]; other site 434131001151 domain II; other site 434131001152 domain III; other site 434131001153 nucleotide binding site [chemical binding]; other site 434131001154 catalytic site [active] 434131001155 domain IV; other site 434131001156 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 434131001157 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 434131001158 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 434131001159 O-methyltransferase; Region: Methyltransf_3; pfam01596 434131001160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131001161 aconitate hydratase; Validated; Region: PRK09277 434131001162 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 434131001163 substrate binding site [chemical binding]; other site 434131001164 ligand binding site [chemical binding]; other site 434131001165 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 434131001166 substrate binding site [chemical binding]; other site 434131001167 Uncharacterized conserved protein [Function unknown]; Region: COG1565 434131001168 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 434131001169 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 434131001170 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 434131001171 active site 434131001172 HIGH motif; other site 434131001173 nucleotide binding site [chemical binding]; other site 434131001174 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 434131001175 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 434131001176 active site 434131001177 KMSKS motif; other site 434131001178 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 434131001179 tRNA binding surface [nucleotide binding]; other site 434131001180 anticodon binding site; other site 434131001181 peptide chain release factor 2; Region: prfB; TIGR00020 434131001182 RF-1 domain; Region: RF-1; cl02875 434131001183 RF-1 domain; Region: RF-1; cl02875 434131001184 large tegument protein UL36; Provisional; Region: PHA03247 434131001185 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 434131001186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 434131001187 ATP binding site [chemical binding]; other site 434131001188 Mg2+ binding site [ion binding]; other site 434131001189 G-X-G motif; other site 434131001190 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 434131001191 ATP binding site [chemical binding]; other site 434131001192 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 434131001193 biotin synthase; Region: bioB; TIGR00433 434131001194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 434131001195 FeS/SAM binding site; other site 434131001196 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 434131001197 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 434131001198 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 434131001199 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 434131001200 catalytic residue [active] 434131001201 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 434131001202 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 434131001203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 434131001204 S-adenosylmethionine binding site [chemical binding]; other site 434131001205 AAA domain; Region: AAA_26; pfam13500 434131001206 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131001207 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 434131001208 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 434131001209 inhibitor-cofactor binding pocket; inhibition site 434131001210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 434131001211 catalytic residue [active] 434131001212 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 434131001213 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00168 434131001214 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 434131001215 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 434131001216 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 434131001217 Subunit I/III interface [polypeptide binding]; other site 434131001218 D-pathway; other site 434131001219 Subunit I/VIIc interface [polypeptide binding]; other site 434131001220 Subunit I/IV interface [polypeptide binding]; other site 434131001221 Subunit I/II interface [polypeptide binding]; other site 434131001222 Low-spin heme (heme a) binding site [chemical binding]; other site 434131001223 Subunit I/VIIa interface [polypeptide binding]; other site 434131001224 Subunit I/VIa interface [polypeptide binding]; other site 434131001225 Dimer interface; other site 434131001226 Putative water exit pathway; other site 434131001227 Binuclear center (heme a3/CuB) [ion binding]; other site 434131001228 K-pathway; other site 434131001229 Subunit I/Vb interface [polypeptide binding]; other site 434131001230 Putative proton exit pathway; other site 434131001231 Subunit I/VIb interface; other site 434131001232 Subunit I/VIc interface [polypeptide binding]; other site 434131001233 Electron transfer pathway; other site 434131001234 Subunit I/VIIIb interface [polypeptide binding]; other site 434131001235 Subunit I/VIIb interface [polypeptide binding]; other site 434131001236 UbiA prenyltransferase family; Region: UbiA; cl00337 434131001237 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 434131001238 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 434131001239 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 434131001240 [2Fe-2S] cluster binding site [ion binding]; other site 434131001241 cytochrome b; Provisional; Region: CYTB; MTH00191 434131001242 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 434131001243 Qi binding site; other site 434131001244 intrachain domain interface; other site 434131001245 interchain domain interface [polypeptide binding]; other site 434131001246 heme bH binding site [chemical binding]; other site 434131001247 heme bL binding site [chemical binding]; other site 434131001248 Qo binding site; other site 434131001249 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 434131001250 interchain domain interface [polypeptide binding]; other site 434131001251 intrachain domain interface; other site 434131001252 Qi binding site; other site 434131001253 Qo binding site; other site 434131001254 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 434131001255 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 434131001256 Protein export membrane protein; Region: SecD_SecF; cl14618 434131001257 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 434131001258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 434131001259 S-adenosylmethionine binding site [chemical binding]; other site 434131001260 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 434131001261 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 434131001262 dimer interface [polypeptide binding]; other site 434131001263 active site 434131001264 CoA binding pocket [chemical binding]; other site 434131001265 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 434131001266 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 434131001267 IncA protein; Region: IncA; pfam04156 434131001268 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 434131001269 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 434131001270 putative dimer interface [polypeptide binding]; other site 434131001271 [2Fe-2S] cluster binding site [ion binding]; other site 434131001272 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 434131001273 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 434131001274 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 434131001275 active site 434131001276 ATP binding site [chemical binding]; other site 434131001277 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 434131001278 IHF dimer interface [polypeptide binding]; other site 434131001279 IHF - DNA interface [nucleotide binding]; other site 434131001280 Transcriptional regulator; Region: Transcrip_reg; cl00361 434131001281 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 434131001282 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 434131001283 ring oligomerisation interface [polypeptide binding]; other site 434131001284 ATP/Mg binding site [chemical binding]; other site 434131001285 stacking interactions; other site 434131001286 hinge regions; other site 434131001287 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 434131001288 oligomerisation interface [polypeptide binding]; other site 434131001289 mobile loop; other site 434131001290 roof hairpin; other site 434131001291 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 434131001292 SurA N-terminal domain; Region: SurA_N_3; cl07813 434131001293 PPIC-type PPIASE domain; Region: Rotamase; cl08278 434131001294 PPIC-type PPIASE domain; Region: Rotamase; cl08278 434131001295 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 434131001296 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 434131001297 active site 434131001298 NTP binding site [chemical binding]; other site 434131001299 metal binding triad [ion binding]; metal-binding site 434131001300 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 434131001301 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 434131001302 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131001303 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 434131001304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 434131001305 Coenzyme A binding pocket [chemical binding]; other site 434131001306 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 434131001307 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 434131001308 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 434131001309 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 434131001310 FAD binding pocket [chemical binding]; other site 434131001311 FAD binding motif [chemical binding]; other site 434131001312 phosphate binding motif [ion binding]; other site 434131001313 beta-alpha-beta structure motif; other site 434131001314 NAD binding pocket [chemical binding]; other site 434131001315 Iron coordination center [ion binding]; other site 434131001316 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 434131001317 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 434131001318 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 434131001319 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 434131001320 NAD(P) binding site [chemical binding]; other site 434131001321 homotetramer interface [polypeptide binding]; other site 434131001322 homodimer interface [polypeptide binding]; other site 434131001323 active site 434131001324 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 434131001325 RNA/DNA hybrid binding site [nucleotide binding]; other site 434131001326 active site 434131001327 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 434131001328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131001329 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 434131001330 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 434131001331 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 434131001332 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 434131001333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131001334 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 434131001335 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 434131001336 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 434131001337 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131001338 G2 box; other site 434131001339 Switch I region; other site 434131001340 G3 box; other site 434131001341 Switch II region; other site 434131001342 GTP/Mg2+ binding site [chemical binding]; other site 434131001343 G4 box; other site 434131001344 G5 box; other site 434131001345 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 434131001346 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 434131001347 DNA polymerase I; Provisional; Region: PRK05755 434131001348 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 434131001349 active site 434131001350 metal binding site 1 [ion binding]; metal-binding site 434131001351 putative 5' ssDNA interaction site; other site 434131001352 metal binding site 3; metal-binding site 434131001353 metal binding site 2 [ion binding]; metal-binding site 434131001354 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 434131001355 putative DNA binding site [nucleotide binding]; other site 434131001356 putative metal binding site [ion binding]; other site 434131001357 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 434131001358 active site 434131001359 DNA binding site [nucleotide binding] 434131001360 catalytic site [active] 434131001361 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 434131001362 Subunit III/VIIa interface [polypeptide binding]; other site 434131001363 Phospholipid binding site [chemical binding]; other site 434131001364 Subunit I/III interface [polypeptide binding]; other site 434131001365 Subunit III/VIb interface [polypeptide binding]; other site 434131001366 Subunit III/VIa interface; other site 434131001367 Subunit III/Vb interface [polypeptide binding]; other site 434131001368 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 434131001369 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 434131001370 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 434131001371 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 434131001372 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 434131001373 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 434131001374 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 434131001375 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 434131001376 DNA binding site [nucleotide binding] 434131001377 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 434131001378 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 434131001379 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 434131001380 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 434131001381 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 434131001382 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 434131001383 RPB11 interaction site [polypeptide binding]; other site 434131001384 RPB12 interaction site [polypeptide binding]; other site 434131001385 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 434131001386 RPB3 interaction site [polypeptide binding]; other site 434131001387 RPB1 interaction site [polypeptide binding]; other site 434131001388 RPB11 interaction site [polypeptide binding]; other site 434131001389 RPB10 interaction site [polypeptide binding]; other site 434131001390 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 434131001391 core dimer interface [polypeptide binding]; other site 434131001392 L11 interface [polypeptide binding]; other site 434131001393 putative EF-Tu interaction site [polypeptide binding]; other site 434131001394 putative EF-G interaction site [polypeptide binding]; other site 434131001395 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 434131001396 23S rRNA interface [nucleotide binding]; other site 434131001397 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 434131001398 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 434131001399 mRNA/rRNA interface [nucleotide binding]; other site 434131001400 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 434131001401 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 434131001402 23S rRNA interface [nucleotide binding]; other site 434131001403 L7/L12 interface [polypeptide binding]; other site 434131001404 putative thiostrepton binding site; other site 434131001405 L25 interface [polypeptide binding]; other site 434131001406 Transcription antiterminator [Transcription]; Region: NusG; COG0250 434131001407 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 434131001408 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 434131001409 elongation factor Tu; Reviewed; Region: PRK00049 434131001410 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 434131001411 G1 box; other site 434131001412 GEF interaction site [polypeptide binding]; other site 434131001413 GTP/Mg2+ binding site [chemical binding]; other site 434131001414 Switch I region; other site 434131001415 G2 box; other site 434131001416 G3 box; other site 434131001417 Switch II region; other site 434131001418 G4 box; other site 434131001419 G5 box; other site 434131001420 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 434131001421 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 434131001422 Antibiotic Binding Site [chemical binding]; other site 434131001423 elongation factor G; Reviewed; Region: PRK00007 434131001424 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 434131001425 G1 box; other site 434131001426 putative GEF interaction site [polypeptide binding]; other site 434131001427 GTP/Mg2+ binding site [chemical binding]; other site 434131001428 Switch I region; other site 434131001429 G2 box; other site 434131001430 G3 box; other site 434131001431 Switch II region; other site 434131001432 G4 box; other site 434131001433 G5 box; other site 434131001434 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 434131001435 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 434131001436 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 434131001437 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 434131001438 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 434131001439 S17 interaction site [polypeptide binding]; other site 434131001440 S8 interaction site; other site 434131001441 16S rRNA interaction site [nucleotide binding]; other site 434131001442 streptomycin interaction site [chemical binding]; other site 434131001443 23S rRNA interaction site [nucleotide binding]; other site 434131001444 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 434131001445 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 434131001446 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 434131001447 ATP binding site [chemical binding]; other site 434131001448 putative Mg++ binding site [ion binding]; other site 434131001449 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 434131001450 nucleotide binding region [chemical binding]; other site 434131001451 ATP-binding site [chemical binding]; other site 434131001452 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00196 434131001453 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 434131001454 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 434131001455 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 434131001456 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 434131001457 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 434131001458 substrate binding pocket [chemical binding]; other site 434131001459 chain length determination region; other site 434131001460 substrate-Mg2+ binding site; other site 434131001461 catalytic residues [active] 434131001462 aspartate-rich region 1; other site 434131001463 active site lid residues [active] 434131001464 aspartate-rich region 2; other site 434131001465 potential protein location (hypothetical protein NRI_0672 [Neorickettsia risticii str. Illinois]) that overlaps RNA (tRNA-T) 434131001466 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 434131001467 Permease; Region: Permease; cl00510 434131001468 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 434131001469 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131001470 Walker A/P-loop; other site 434131001471 ATP binding site [chemical binding]; other site 434131001472 Q-loop/lid; other site 434131001473 ABC transporter signature motif; other site 434131001474 Walker B; other site 434131001475 D-loop; other site 434131001476 H-loop/switch region; other site 434131001477 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131001478 AAA domain; Region: AAA_21; pfam13304 434131001479 Walker A/P-loop; other site 434131001480 ATP binding site [chemical binding]; other site 434131001481 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131001482 Q-loop/lid; other site 434131001483 ABC transporter signature motif; other site 434131001484 Walker B; other site 434131001485 D-loop; other site 434131001486 H-loop/switch region; other site 434131001487 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 434131001488 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 434131001489 RNA/DNA hybrid binding site [nucleotide binding]; other site 434131001490 active site 434131001491 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 434131001492 TPP-binding site [chemical binding]; other site 434131001493 dimer interface [polypeptide binding]; other site 434131001494 transketolase; Provisional; Region: PTZ00089 434131001495 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 434131001496 PYR/PP interface [polypeptide binding]; other site 434131001497 dimer interface [polypeptide binding]; other site 434131001498 TPP binding site [chemical binding]; other site 434131001499 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 434131001500 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 434131001501 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 434131001502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131001503 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 434131001504 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 434131001505 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 434131001506 active site 434131001507 KMSKS motif; other site 434131001508 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 434131001509 DHH family; Region: DHH; pfam01368 434131001510 DHHA1 domain; Region: DHHA1; pfam02272 434131001511 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 434131001512 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 434131001513 SLBB domain; Region: SLBB; pfam10531 434131001514 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 434131001515 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 434131001516 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 434131001517 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 434131001518 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 434131001519 trmE is a tRNA modification GTPase; Region: trmE; cd04164 434131001520 G1 box; other site 434131001521 Switch I region; other site 434131001522 G2 box; other site 434131001523 Switch II region; other site 434131001524 G3 box; other site 434131001525 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 434131001526 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 434131001527 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 434131001528 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 434131001529 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 434131001530 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 434131001531 Surface antigen; Region: Bac_surface_Ag; cl03097 434131001532 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 434131001533 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 434131001534 active site 434131001535 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 434131001536 protein binding site [polypeptide binding]; other site 434131001537 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 434131001538 putative substrate binding region [chemical binding]; other site 434131001539 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14610 434131001540 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 434131001541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 434131001542 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 434131001543 anchoring element; other site 434131001544 dimer interface [polypeptide binding]; other site 434131001545 ATP binding site [chemical binding]; other site 434131001546 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 434131001547 active site 434131001548 putative metal-binding site [ion binding]; other site 434131001549 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 434131001550 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 434131001551 catalytic triad [active] 434131001552 Sodium:solute symporter family; Region: SSF; cl00456 434131001553 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 434131001554 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 434131001555 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 434131001556 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 434131001557 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 434131001558 catalytic site [active] 434131001559 G-X2-G-X-G-K; other site 434131001560 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 434131001561 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 434131001562 Citrate synthase; Region: Citrate_synt; pfam00285 434131001563 oxalacetate binding site [chemical binding]; other site 434131001564 citrylCoA binding site [chemical binding]; other site 434131001565 coenzyme A binding site [chemical binding]; other site 434131001566 catalytic triad [active] 434131001567 enolase; Provisional; Region: eno; PRK00077 434131001568 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 434131001569 dimer interface [polypeptide binding]; other site 434131001570 metal binding site [ion binding]; metal-binding site 434131001571 substrate binding pocket [chemical binding]; other site 434131001572 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 434131001573 dimer interface [polypeptide binding]; other site 434131001574 substrate binding site [chemical binding]; other site 434131001575 metal binding sites [ion binding]; metal-binding site 434131001576 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 434131001577 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 434131001578 catalytic site [active] 434131001579 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 434131001580 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 434131001581 active site 434131001582 HIGH motif; other site 434131001583 KMSKS motif; other site 434131001584 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 434131001585 type IV secretion system component VirD4; Provisional; Region: PRK13897 434131001586 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 434131001587 Walker A motif; other site 434131001588 ATP binding site [chemical binding]; other site 434131001589 Walker B motif; other site 434131001590 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 434131001591 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 434131001592 Walker A motif; other site 434131001593 hexamer interface [polypeptide binding]; other site 434131001594 ATP binding site [chemical binding]; other site 434131001595 Walker B motif; other site 434131001596 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 434131001597 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 434131001598 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 434131001599 VirB7 interaction site; other site 434131001600 VirB8 protein; Region: VirB8; cl01500 434131001601 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 434131001602 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 434131001603 dimerization interface [polypeptide binding]; other site 434131001604 active site 434131001605 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 434131001606 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 434131001607 alpha subunit interface [polypeptide binding]; other site 434131001608 TPP binding site [chemical binding]; other site 434131001609 heterodimer interface [polypeptide binding]; other site 434131001610 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 434131001611 Cell division protein ZapA; Region: ZapA; cl01146 434131001612 trigger factor; Region: tig; TIGR00115 434131001613 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 434131001614 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 434131001615 Clp protease; Region: CLP_protease; pfam00574 434131001616 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 434131001617 oligomer interface [polypeptide binding]; other site 434131001618 active site residues [active] 434131001619 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 434131001620 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 434131001621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 434131001622 Walker A motif; other site 434131001623 ATP binding site [chemical binding]; other site 434131001624 Walker B motif; other site 434131001625 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 434131001626 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 434131001627 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 434131001628 motif 1; other site 434131001629 dimer interface [polypeptide binding]; other site 434131001630 active site 434131001631 motif 2; other site 434131001632 motif 3; other site 434131001633 aspartate aminotransferase; Provisional; Region: PRK05764 434131001634 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 434131001635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 434131001636 homodimer interface [polypeptide binding]; other site 434131001637 catalytic residue [active] 434131001638 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 434131001639 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 434131001640 dimer interface [polypeptide binding]; other site 434131001641 ssDNA binding site [nucleotide binding]; other site 434131001642 tetramer (dimer of dimers) interface [polypeptide binding]; other site 434131001643 Helix-turn-helix domains; Region: HTH; cl00088 434131001644 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 434131001645 active site 434131001646 intersubunit interactions; other site 434131001647 catalytic residue [active] 434131001648 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 434131001649 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 434131001650 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 434131001651 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 434131001652 alpha subunit interaction interface [polypeptide binding]; other site 434131001653 Walker A motif; other site 434131001654 ATP binding site [chemical binding]; other site 434131001655 Walker B motif; other site 434131001656 inhibitor binding site; inhibition site 434131001657 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 434131001658 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 434131001659 TrbC/VIRB2 family; Region: TrbC; cl01583 434131001660 TrbC/VIRB2 family; Region: TrbC; cl01583 434131001661 GTP-binding protein LepA; Provisional; Region: PRK05433 434131001662 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 434131001663 G1 box; other site 434131001664 putative GEF interaction site [polypeptide binding]; other site 434131001665 GTP/Mg2+ binding site [chemical binding]; other site 434131001666 Switch I region; other site 434131001667 G2 box; other site 434131001668 G3 box; other site 434131001669 Switch II region; other site 434131001670 G4 box; other site 434131001671 G5 box; other site 434131001672 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 434131001673 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 434131001674 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 434131001675 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 434131001676 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 434131001677 active site 434131001678 nucleotide binding site [chemical binding]; other site 434131001679 HIGH motif; other site 434131001680 KMSKS motif; other site 434131001681 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 434131001682 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 434131001683 ATP binding site [chemical binding]; other site 434131001684 substrate interface [chemical binding]; other site 434131001685 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 434131001686 XdhC Rossmann domain; Region: XdhC_C; pfam13478 434131001687 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 434131001688 histidyl-tRNA synthetase; Region: hisS; TIGR00442 434131001689 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 434131001690 dimer interface [polypeptide binding]; other site 434131001691 motif 1; other site 434131001692 active site 434131001693 motif 2; other site 434131001694 motif 3; other site 434131001695 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 434131001696 anticodon binding site; other site 434131001697 BolA-like protein; Region: BolA; cl00386 434131001698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 434131001699 metabolite-proton symporter; Region: 2A0106; TIGR00883 434131001700 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 434131001701 Catalytic site [active] 434131001702 signal peptidase I; Provisional; Region: PRK10861 434131001703 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 434131001704 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 434131001705 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 434131001706 ferrochelatase; Reviewed; Region: hemH; PRK00035 434131001707 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 434131001708 C-terminal domain interface [polypeptide binding]; other site 434131001709 active site 434131001710 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 434131001711 active site 434131001712 N-terminal domain interface [polypeptide binding]; other site 434131001713 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 434131001714 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 434131001715 active site 434131001716 dimer interface [polypeptide binding]; other site 434131001717 Integral membrane protein TerC family; Region: TerC; cl10468 434131001718 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 434131001719 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 434131001720 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 434131001721 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 434131001722 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 434131001723 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 434131001724 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 434131001725 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 434131001726 active site 434131001727 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 434131001728 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 434131001729 tetramer interface [polypeptide binding]; other site 434131001730 TPP-binding site [chemical binding]; other site 434131001731 heterodimer interface [polypeptide binding]; other site 434131001732 phosphorylation loop region [posttranslational modification] 434131001733 UbiA prenyltransferase family; Region: UbiA; cl00337 434131001734 Flavin Reductases; Region: FlaRed; cl00801 434131001735 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 434131001736 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 434131001737 Walker A/P-loop; other site 434131001738 ATP binding site [chemical binding]; other site 434131001739 Q-loop/lid; other site 434131001740 ABC transporter signature motif; other site 434131001741 Walker B; other site 434131001742 D-loop; other site 434131001743 H-loop/switch region; other site 434131001744 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 434131001745 SmpB-tmRNA interface; other site 434131001746 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 434131001747 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 434131001748 dimerization interface [polypeptide binding]; other site 434131001749 ATP binding site [chemical binding]; other site 434131001750 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 434131001751 dimerization interface [polypeptide binding]; other site 434131001752 ATP binding site [chemical binding]; other site 434131001753 muropeptide transporter; Reviewed; Region: ampG; PRK11902 434131001754 muropeptide transporter; Validated; Region: ampG; PRK11010 434131001755 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 434131001756 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 434131001757 ATP-grasp domain; Region: ATP-grasp_4; cl03087 434131001758 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 434131001759 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 434131001760 carboxyltransferase (CT) interaction site; other site 434131001761 biotinylation site [posttranslational modification]; other site 434131001762 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 434131001763 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 434131001764 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 434131001765 active site 434131001766 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 434131001767 NifU-like domain; Region: NifU; cl00484 434131001768 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 434131001769 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 434131001770 HSP70 interaction site [polypeptide binding]; other site 434131001771 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 434131001772 4Fe-4S binding domain; Region: Fer4; cl02805 434131001773 4Fe-4S binding domain; Region: Fer4; cl02805 434131001774 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 434131001775 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 434131001776 homodimer interface [polypeptide binding]; other site 434131001777 NADP binding site [chemical binding]; other site 434131001778 substrate binding site [chemical binding]; other site 434131001779 potential protein location (hypothetical protein NRI_0789 [Neorickettsia risticii str. Illinois]) that overlaps RNA (tRNA-S) 434131001780 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 434131001781 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 434131001782 active site 434131001783 metal binding site [ion binding]; metal-binding site 434131001784 potential protein location (hypothetical protein NRI_0796 [Neorickettsia risticii str. Illinois]) that overlaps RNA (tRNA-G) 434131001785 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 434131001786 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 434131001787 substrate-cofactor binding pocket; other site 434131001788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 434131001789 catalytic residue [active] 434131001790 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 434131001791 CcmE; Region: CcmE; cl00994 434131001792 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 434131001793 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 434131001794 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 434131001795 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 434131001796 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 434131001797 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 434131001798 FeS/SAM binding site; other site 434131001799 TRAM domain; Region: TRAM; cl01282 434131001800 DNA photolyase; Region: DNA_photolyase; pfam00875 434131001801 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 434131001802 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 434131001803 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 434131001804 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 434131001805 23S rRNA interface [nucleotide binding]; other site 434131001806 L3 interface [polypeptide binding]; other site 434131001807 Colicin V production protein; Region: Colicin_V; cl00567 434131001808 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 434131001809 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 434131001810 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 434131001811 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 434131001812 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 434131001813 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 434131001814 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 434131001815 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 434131001816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 434131001817 Major Facilitator Superfamily; Region: MFS_1; pfam07690 434131001818 putative substrate translocation pore; other site 434131001819 Mechanosensitive ion channel; Region: MS_channel; pfam00924 434131001820 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 434131001821 intersubunit interface [polypeptide binding]; other site 434131001822 active site 434131001823 Zn2+ binding site [ion binding]; other site 434131001824 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 434131001825 inhibitor-cofactor binding pocket; inhibition site 434131001826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 434131001827 catalytic residue [active] 434131001828 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 434131001829 active site 434131001830 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 434131001831 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 434131001832 ATP binding site [chemical binding]; other site 434131001833 active site 434131001834 substrate binding site [chemical binding]; other site 434131001835 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 434131001836 Lumazine binding domain; Region: Lum_binding; pfam00677 434131001837 Lumazine binding domain; Region: Lum_binding; pfam00677 434131001838 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 434131001839 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 434131001840 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 434131001841 Ribonuclease P; Region: Ribonuclease_P; cl00457 434131001842 Haemolytic domain; Region: Haemolytic; cl00506 434131001843 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 434131001844 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 434131001845 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 434131001846 tegument protein VP11/12; Provisional; Region: PHA03321 434131001847 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 434131001848 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 434131001849 type IV secretion system ATPase VirB4; Provisional; Region: PRK13898 434131001850 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 434131001851 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131001852 Walker A/P-loop; other site 434131001853 ATP binding site [chemical binding]; other site 434131001854 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 434131001855 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 434131001856 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 434131001857 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 434131001858 Walker A/P-loop; other site 434131001859 ATP binding site [chemical binding]; other site 434131001860 Q-loop/lid; other site 434131001861 ABC transporter signature motif; other site 434131001862 Walker B; other site 434131001863 D-loop; other site 434131001864 H-loop/switch region; other site 434131001865 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 434131001866 active site 434131001867 nucleophile elbow; other site 434131001868 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 434131001869 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 434131001870 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 434131001871 CTP synthetase; Validated; Region: pyrG; PRK05380 434131001872 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 434131001873 Catalytic site [active] 434131001874 active site 434131001875 UTP binding site [chemical binding]; other site 434131001876 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 434131001877 active site 434131001878 putative oxyanion hole; other site 434131001879 catalytic triad [active] 434131001880 potential protein location (hypothetical protein NRI_0845 [Neorickettsia risticii str. Illinois]) that overlaps RNA (tRNA-A) 434131001881 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 434131001882 putative RNA binding site [nucleotide binding]; other site 434131001883 Maf-like protein; Region: Maf; pfam02545 434131001884 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 434131001885 active site 434131001886 dimer interface [polypeptide binding]; other site 434131001887 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 434131001888 RNA binding site [nucleotide binding]; other site 434131001889 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 434131001890 putative catalytic residue [active] 434131001891 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 434131001892 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 434131001893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131001894 GMP synthase; Reviewed; Region: guaA; PRK00074 434131001895 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 434131001896 AMP/PPi binding site [chemical binding]; other site 434131001897 candidate oxyanion hole; other site 434131001898 catalytic triad [active] 434131001899 potential glutamine specificity residues [chemical binding]; other site 434131001900 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 434131001901 ATP Binding subdomain [chemical binding]; other site 434131001902 Ligand Binding sites [chemical binding]; other site 434131001903 Dimerization subdomain; other site 434131001904 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 434131001905 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 434131001906 Walker A motif; other site 434131001907 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 434131001908 ligand binding site [chemical binding]; other site 434131001909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 434131001910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 434131001911 binding surface 434131001912 TPR motif; other site 434131001913 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 434131001914 Sulfatase; Region: Sulfatase; cl10460 434131001915 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 434131001916 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 434131001917 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 434131001918 active site 434131001919 HIGH motif; other site 434131001920 KMSKS motif; other site 434131001921 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 434131001922 tRNA binding surface [nucleotide binding]; other site 434131001923 anticodon binding site; other site 434131001924 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 434131001925 catalytic residues [active] 434131001926 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 434131001927 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 434131001928 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 434131001929 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 434131001930 recombination protein RecR; Reviewed; Region: recR; PRK00076 434131001931 RecR protein; Region: RecR; pfam02132 434131001932 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 434131001933 putative active site [active] 434131001934 putative metal-binding site [ion binding]; other site 434131001935 tetramer interface [polypeptide binding]; other site 434131001936 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 434131001937 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 434131001938 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 434131001939 catalytic residues [active] 434131001940 GTP-binding protein YchF; Reviewed; Region: PRK09601 434131001941 YchF GTPase; Region: YchF; cd01900 434131001942 G1 box; other site 434131001943 GTP/Mg2+ binding site [chemical binding]; other site 434131001944 Switch I region; other site 434131001945 G2 box; other site 434131001946 Switch II region; other site 434131001947 G3 box; other site 434131001948 G4 box; other site 434131001949 G5 box; other site 434131001950 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 434131001951 potential protein location (hypothetical protein NRI_0875 [Neorickettsia risticii str. Illinois]) that overlaps RNA (tRNA-R) 434131001952 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 434131001953 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 434131001954 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 434131001955 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 434131001956 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 434131001957 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 434131001958 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 434131001959 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 434131001960 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 434131001961 Zn binding site [ion binding]; other site 434131001962 ribonuclease III; Reviewed; Region: rnc; PRK00102 434131001963 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 434131001964 dimerization interface [polypeptide binding]; other site 434131001965 active site 434131001966 metal binding site [ion binding]; metal-binding site 434131001967 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 434131001968 dsRNA binding site [nucleotide binding]; other site 434131001969 Oligomerisation domain; Region: Oligomerisation; cl00519 434131001970 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 434131001971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131001972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 434131001973 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 434131001974 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 434131001975 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 434131001976 ATP-grasp domain; Region: ATP-grasp_4; cl03087 434131001977 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 434131001978 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 434131001979 dihydrodipicolinate synthase; Region: dapA; TIGR00674 434131001980 dimer interface [polypeptide binding]; other site 434131001981 active site 434131001982 catalytic residue [active] 434131001983 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 434131001984 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 434131001985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 434131001986 motif II; other site 434131001987 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 434131001988 Fe-S cluster binding site [ion binding]; other site 434131001989 active site 434131001990 VacJ like lipoprotein; Region: VacJ; cl01073 434131001991 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 434131001992 Domain of unknown function (DUF2610); Region: DUF2610; pfam11020 434131001993 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 434131001994 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 434131001995 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 434131001996 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 434131001997 active site 434131001998 metal binding site [ion binding]; metal-binding site 434131001999 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 434131002000 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 434131002001 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 434131002002 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 434131002003 catalytic residue [active] 434131002004 putative FPP diphosphate binding site; other site 434131002005 putative FPP binding hydrophobic cleft; other site 434131002006 dimer interface [polypeptide binding]; other site 434131002007 putative IPP diphosphate binding site; other site 434131002008 ribosome recycling factor; Reviewed; Region: frr; PRK00083 434131002009 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 434131002010 hinge region; other site 434131002011 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 434131002012 putative nucleotide binding site [chemical binding]; other site 434131002013 uridine monophosphate binding site [chemical binding]; other site 434131002014 homohexameric interface [polypeptide binding]; other site 434131002015 elongation factor Ts; Provisional; Region: tsf; PRK09377 434131002016 Elongation factor TS; Region: EF_TS; pfam00889 434131002017 Elongation factor TS; Region: EF_TS; pfam00889 434131002018 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 434131002019 rRNA interaction site [nucleotide binding]; other site 434131002020 S8 interaction site; other site 434131002021 putative laminin-1 binding site; other site 434131002022 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 434131002023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 434131002024 S-adenosylmethionine binding site [chemical binding]; other site 434131002025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131002026 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 434131002027 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 434131002028 E3 interaction surface; other site 434131002029 lipoyl attachment site [posttranslational modification]; other site 434131002030 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 434131002031 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 434131002032 substrate binding site [chemical binding]; other site 434131002033 dimer interface [polypeptide binding]; other site 434131002034 ATP binding site [chemical binding]; other site 434131002035 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 434131002036 active site 434131002037 putative DNA-binding cleft [nucleotide binding]; other site 434131002038 dimer interface [polypeptide binding]; other site 434131002039 malate dehydrogenase; Reviewed; Region: PRK06223 434131002040 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 434131002041 NAD(P) binding site [chemical binding]; other site 434131002042 dimer interface [polypeptide binding]; other site 434131002043 tetramer (dimer of dimers) interface [polypeptide binding]; other site 434131002044 substrate binding site [chemical binding]; other site 434131002045 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 434131002046 trimer interface [polypeptide binding]; other site 434131002047 active site 434131002048 DNA gyrase subunit A; Validated; Region: PRK05560 434131002049 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 434131002050 CAP-like domain; other site 434131002051 active site 434131002052 primary dimer interface [polypeptide binding]; other site 434131002053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 434131002054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 434131002055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 434131002056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 434131002057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 434131002058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 434131002059 GTPase Era; Reviewed; Region: era; PRK00089 434131002060 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 434131002061 G1 box; other site 434131002062 GTP/Mg2+ binding site [chemical binding]; other site 434131002063 Switch I region; other site 434131002064 G2 box; other site 434131002065 Switch II region; other site 434131002066 G3 box; other site 434131002067 G4 box; other site 434131002068 G5 box; other site 434131002069 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 434131002070 Acyl transferase domain; Region: Acyl_transf_1; cl08282 434131002071 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 434131002072 DNA primase; Validated; Region: dnaG; PRK05667 434131002073 CHC2 zinc finger; Region: zf-CHC2; cl15369 434131002074 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 434131002075 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 434131002076 active site 434131002077 metal binding site [ion binding]; metal-binding site 434131002078 interdomain interaction site; other site 434131002079 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 434131002080 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 434131002081 trimer interface [polypeptide binding]; other site 434131002082 active site 434131002083 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 434131002084 ATP-grasp domain; Region: ATP-grasp_4; cl03087 434131002085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 434131002086 NAD(P) binding site [chemical binding]; other site 434131002087 active site 434131002088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 434131002089 Terminase-like family; Region: Terminase_6; pfam03237 434131002090 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 434131002091 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 434131002092 substrate binding site [chemical binding]; other site 434131002093 active site 434131002094 Quinolinate synthetase A protein; Region: NadA; cl00420 434131002095 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 434131002096 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 434131002097 active site 434131002098 (T/H)XGH motif; other site