-- dump date   	20111121_013623
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
323848000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
323848000002	hypothetical protein; Validated; Region: PRK06672
323848000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848000004	Walker A motif; other site
323848000005	ATP binding site [chemical binding]; other site
323848000006	Walker B motif; other site
323848000007	arginine finger; other site
323848000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
323848000009	DnaA box-binding interface [nucleotide binding]; other site
323848000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
323848000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140
323848000012	putative DNA binding surface [nucleotide binding]; other site
323848000013	dimer interface [polypeptide binding]; other site
323848000014	beta-clamp/clamp loader binding surface; other site
323848000015	beta-clamp/translesion DNA polymerase binding surface; other site
323848000016	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
323848000017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
323848000018	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
323848000019	anchoring element; other site
323848000020	dimer interface [polypeptide binding]; other site
323848000021	ATP binding site [chemical binding]; other site
323848000022	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
323848000023	active site
323848000024	putative metal-binding site [ion binding]; other site
323848000025	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
323848000026	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
323848000027	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378
323848000028	dimer interface [polypeptide binding]; other site
323848000029	glycine-pyridoxal phosphate binding site [chemical binding]; other site
323848000030	active site
323848000031	folate binding site [chemical binding]; other site
323848000032	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
323848000033	ATP cone domain; Region: ATP-cone; pfam03477
323848000034	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
323848000035	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
323848000036	catalytic motif [active]
323848000037	Zn binding site [ion binding]; other site
323848000038	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
323848000039	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
323848000040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848000041	active site
323848000042	phosphorylation site [posttranslational modification]
323848000043	intermolecular recognition site; other site
323848000044	dimerization interface [polypeptide binding]; other site
323848000045	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
323848000046	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323848000047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848000048	ATP binding site [chemical binding]; other site
323848000049	G-X-G motif; other site
323848000050	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
323848000051	Lumazine binding domain; Region: Lum_binding; pfam00677
323848000052	Lumazine binding domain; Region: Lum_binding; pfam00677
323848000053	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
323848000054	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
323848000055	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
323848000056	dimerization interface [polypeptide binding]; other site
323848000057	active site
323848000058	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
323848000059	homopentamer interface [polypeptide binding]; other site
323848000060	active site
323848000061	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223
323848000062	putative RNA binding site [nucleotide binding]; other site
323848000063	thiamine monophosphate kinase; Provisional; Region: PRK05731
323848000064	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
323848000065	ATP binding site [chemical binding]; other site
323848000066	dimerization interface [polypeptide binding]; other site
323848000067	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
323848000068	tetramer interfaces [polypeptide binding]; other site
323848000069	binuclear metal-binding site [ion binding]; other site
323848000070	Competence-damaged protein; Region: CinA; cl00666
323848000071	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
323848000072	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
323848000073	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848000074	binding surface
323848000075	TPR motif; other site
323848000076	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848000077	binding surface
323848000078	TPR motif; other site
323848000079	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848000080	binding surface
323848000081	TPR motif; other site
323848000082	recombinase A; Provisional; Region: recA; PRK09354
323848000083	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
323848000084	hexamer interface [polypeptide binding]; other site
323848000085	Walker A motif; other site
323848000086	ATP binding site [chemical binding]; other site
323848000087	Walker B motif; other site
323848000088	RecX family; Region: RecX; cl00936
323848000089	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
323848000090	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673
323848000091	motif 1; other site
323848000092	active site
323848000093	motif 2; other site
323848000094	motif 3; other site
323848000095	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
323848000096	DHHA1 domain; Region: DHHA1; pfam02272
323848000097	thioredoxin reductase; Provisional; Region: PRK10262
323848000098	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848000099	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
323848000100	Smr domain; Region: Smr; cl02619
323848000101	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
323848000102	Major Facilitator Superfamily; Region: MFS_1; pfam07690
323848000103	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323848000104	Protein of unknown function (DUF445); Region: DUF445; pfam04286
323848000105	S-adenosylmethionine synthetase; Provisional; Region: PRK12459
323848000106	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
323848000107	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
323848000108	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
323848000109	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
323848000110	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
323848000111	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323848000112	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
323848000113	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
323848000114	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848000115	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
323848000116	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes...; Region: Topo_IB_C; cd00659
323848000117	DNA binding site [nucleotide binding]
323848000118	active site
323848000119	Int/Topo IB signature motif; other site
323848000120	catalytic residues [active]
323848000121	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
323848000122	dimer interface [polypeptide binding]; other site
323848000123	ligand binding site [chemical binding]; other site
323848000124	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
323848000125	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323848000126	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323848000127	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
323848000128	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
323848000129	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105
323848000130	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
323848000131	substrate binding pocket [chemical binding]; other site
323848000132	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
323848000133	B12 binding site [chemical binding]; other site
323848000134	cobalt ligand [ion binding]; other site
323848000135	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
323848000136	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848000137	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323848000138	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848000139	Uncharacterised ACR, COG2135; Region: DUF159; cl03646
323848000140	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
323848000141	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
323848000142	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
323848000143	synthetase active site [active]
323848000144	NTP binding site [chemical binding]; other site
323848000145	metal binding site [ion binding]; metal-binding site
323848000146	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
323848000147	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
323848000148	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
323848000149	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071
323848000150	catalytic site [active]
323848000151	G-X2-G-X-G-K; other site
323848000152	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
323848000153	catalytic residues [active]
323848000154	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848000155	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
323848000156	Integrase core domain; Region: rve; cl01316
323848000157	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
323848000158	tandem repeat interface [polypeptide binding]; other site
323848000159	oligomer interface [polypeptide binding]; other site
323848000160	active site residues [active]
323848000161	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
323848000162	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
323848000163	Phage integrase family; Region: Phage_integrase; pfam00589
323848000164	active site
323848000165	Int/Topo IB signature motif; other site
323848000166	hypothetical protein; Provisional; Region: PRK11820
323848000167	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
323848000168	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
323848000169	ribonuclease PH; Reviewed; Region: rph; PRK00173
323848000170	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
323848000171	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
323848000172	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515
323848000173	active site
323848000174	dimerization interface [polypeptide binding]; other site
323848000175	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
323848000176	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
323848000177	FeS/SAM binding site; other site
323848000178	HemN C-terminal region; Region: HemN_C; pfam06969
323848000179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848000180	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
323848000181	ThiS interaction site; other site
323848000182	putative active site [active]
323848000183	tetramer interface [polypeptide binding]; other site
323848000184	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
323848000185	thiS-thiF/thiG interaction site; other site
323848000186	HPP family; Region: HPP; pfam04982
323848000187	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
323848000188	dimerization interface [polypeptide binding]; other site
323848000189	Ion transport protein; Region: Ion_trans; pfam00520
323848000190	Ion channel; Region: Ion_trans_2; cl11596
323848000191	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
323848000192	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
323848000193	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
323848000194	minor groove reading motif; other site
323848000195	helix-hairpin-helix signature motif; other site
323848000196	substrate binding pocket [chemical binding]; other site
323848000197	active site
323848000198	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
323848000199	DNA binding and oxoG recognition site [nucleotide binding]
323848000200	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
323848000201	aromatic acid decarboxylase; Validated; Region: PRK05920
323848000202	Flavoprotein; Region: Flavoprotein; cl08021
323848000203	P-loop ATPase protein family; Region: ATP_bind_2; cl10035
323848000204	HPr kinase/phosphorylase; Provisional; Region: PRK05428
323848000205	DRTGG domain; Region: DRTGG; cl12147
323848000206	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918
323848000207	Hpr binding site; other site
323848000208	active site
323848000209	homohexamer subunit interaction site [polypeptide binding]; other site
323848000210	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552
323848000211	30S subunit binding site; other site
323848000212	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
323848000213	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
323848000214	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
323848000215	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
323848000216	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
323848000217	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
323848000218	Walker A/P-loop; other site
323848000219	ATP binding site [chemical binding]; other site
323848000220	Q-loop/lid; other site
323848000221	ABC transporter signature motif; other site
323848000222	Walker B; other site
323848000223	D-loop; other site
323848000224	H-loop/switch region; other site
323848000225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
323848000226	OstA-like protein; Region: OstA; cl00844
323848000227	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
323848000228	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
323848000229	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
323848000230	LytB protein; Region: LYTB; cl00507
323848000231	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
323848000232	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
323848000233	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144
323848000234	cobalamin binding residues [chemical binding]; other site
323848000235	putative BtuC binding residues; other site
323848000236	dimer interface [polypeptide binding]; other site
323848000237	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
323848000238	NeuB family; Region: NeuB; cl00496
323848000239	IPP transferase; Region: IPPT; cl00403
323848000240	BON domain; Region: BON; cl02771
323848000241	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
323848000242	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
323848000243	active site
323848000244	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
323848000245	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
323848000246	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848000247	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848000248	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442
323848000249	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
323848000250	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848000251	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
323848000252	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
323848000253	substrate binding site [chemical binding]; other site
323848000254	oxyanion hole (OAH) forming residues; other site
323848000255	trimer interface [polypeptide binding]; other site
323848000256	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
323848000257	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
323848000258	dimer interface [polypeptide binding]; other site
323848000259	active site
323848000260	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
323848000261	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
323848000262	short chain dehydrogenase; Provisional; Region: PRK05693
323848000263	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
323848000264	NADP binding site [chemical binding]; other site
323848000265	active site
323848000266	steroid binding site; other site
323848000267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848000268	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323848000269	Sel1 repeat; Region: Sel1; cl02723
323848000270	Sel1 repeat; Region: Sel1; cl02723
323848000271	Sel1 repeat; Region: Sel1; cl02723
323848000272	Sel1 repeat; Region: Sel1; cl02723
323848000273	Sel1 repeat; Region: Sel1; cl02723
323848000274	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323848000275	Sel1 repeat; Region: Sel1; cl02723
323848000276	Sel1 repeat; Region: Sel1; cl02723
323848000277	Sel1 repeat; Region: Sel1; cl02723
323848000278	Sel1 repeat; Region: Sel1; cl02723
323848000279	Sel1 repeat; Region: Sel1; cl02723
323848000280	Protein of unknown function (DUF445); Region: DUF445; pfam04286
323848000281	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848000282	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
323848000283	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
323848000284	catalytic residues [active]
323848000285	catalytic nucleophile [active]
323848000286	Recombinase; Region: Recombinase; pfam07508
323848000287	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848000288	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
323848000289	Integrase core domain; Region: rve; cl01316
323848000290	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
323848000291	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
323848000292	Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_3; cd04327
323848000293	active site
323848000294	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
323848000295	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
323848000296	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848000297	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
323848000298	catalytic motif [active]
323848000299	Zn binding site [ion binding]; other site
323848000300	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848000301	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
323848000302	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083
323848000303	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
323848000304	C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182
323848000305	DNA binding site [nucleotide binding]
323848000306	active site
323848000307	Int/Topo IB signature motif; other site
323848000308	catalytic residues [active]
323848000309	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
323848000310	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848000311	Membrane fusogenic activity; Region: BMFP; cl01115
323848000312	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
323848000313	Phosphotransferase enzyme family; Region: APH; pfam01636
323848000314	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
323848000315	Substrate binding site [chemical binding]; other site
323848000316	metal binding site [ion binding]; metal-binding site
323848000317	proline aminopeptidase P II; Provisional; Region: PRK10879
323848000318	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
323848000319	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087
323848000320	active site
323848000321	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848000322	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
323848000323	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
323848000324	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
323848000325	FMN binding site [chemical binding]; other site
323848000326	active site
323848000327	catalytic residues [active]
323848000328	substrate binding site [chemical binding]; other site
323848000329	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
323848000330	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
323848000331	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421
323848000332	purine monophosphate binding site [chemical binding]; other site
323848000333	dimer interface [polypeptide binding]; other site
323848000334	putative catalytic residues [active]
323848000335	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
323848000336	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
323848000337	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
323848000338	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
323848000339	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848000340	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
323848000341	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433
323848000342	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323848000343	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848000344	putative transposase OrfB; Reviewed; Region: PHA02517
323848000345	Integrase core domain; Region: rve; cl01316
323848000346	Cupin superfamily protein; Region: Cupin_4; pfam08007
323848000347	Cupin domain; Region: Cupin_2; cl09118
323848000348	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
323848000349	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
323848000350	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848000351	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
323848000352	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848000353	Walker B; other site
323848000354	D-loop; other site
323848000355	H-loop/switch region; other site
323848000356	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
323848000357	nucleoside/Zn binding site; other site
323848000358	dimer interface [polypeptide binding]; other site
323848000359	catalytic motif [active]
323848000360	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
323848000361	Ubiquitin-like proteins; Region: UBQ; cl00155
323848000362	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
323848000363	Protein of unknown function DUF82; Region: DUF82; pfam01927
323848000364	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
323848000365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848000366	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
323848000367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848000368	Staphylococcal nuclease homologues; Region: SNc; smart00318
323848000369	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
323848000370	Catalytic site; other site
323848000371	Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966
323848000372	Response regulator receiver domain; Region: Response_reg; pfam00072
323848000373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848000374	active site
323848000375	phosphorylation site [posttranslational modification]
323848000376	intermolecular recognition site; other site
323848000377	dimerization interface [polypeptide binding]; other site
323848000378	hypothetical protein; Provisional; Region: PRK10279
323848000379	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
323848000380	active site
323848000381	nucleophile elbow; other site
323848000382	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
323848000383	dimerization interface [polypeptide binding]; other site
323848000384	DNA binding residues [nucleotide binding]
323848000385	transcriptional regulator EpsA; Region: EpsA; TIGR03020
323848000386	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
323848000387	Integrase core domain; Region: rve; cl01316
323848000388	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848000389	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
323848000390	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
323848000391	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848000392	tartronate semialdehyde reductase; Provisional; Region: PRK15059
323848000393	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848000394	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
323848000395	FAD binding domain; Region: FAD_binding_4; pfam01565
323848000396	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
323848000397	FAD binding domain; Region: FAD_binding_4; pfam01565
323848000398	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
323848000399	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
323848000400	Cysteine-rich domain; Region: CCG; pfam02754
323848000401	DNA translocase FtsK; Provisional; Region: PRK10263
323848000402	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848000403	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
323848000404	Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; cl04829
323848000405	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
323848000406	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
323848000407	recombination factor protein RarA; Reviewed; Region: PRK13342
323848000408	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848000409	Walker A motif; other site
323848000410	ATP binding site [chemical binding]; other site
323848000411	Walker B motif; other site
323848000412	arginine finger; other site
323848000413	MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440
323848000414	seryl-tRNA synthetase; Provisional; Region: PRK05431
323848000415	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
323848000416	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
323848000417	dimer interface [polypeptide binding]; other site
323848000418	active site
323848000419	motif 1; other site
323848000420	motif 2; other site
323848000421	motif 3; other site
323848000422	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
323848000423	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
323848000424	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
323848000425	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
323848000426	Cytochrome c; Region: Cytochrom_C; cl11414
323848000427	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
323848000428	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
323848000429	Subunit I/III interface [polypeptide binding]; other site
323848000430	D-pathway; other site
323848000431	Subunit I/VIIc interface [polypeptide binding]; other site
323848000432	Subunit I/IV interface [polypeptide binding]; other site
323848000433	Subunit I/II interface [polypeptide binding]; other site
323848000434	Low-spin heme (heme a) binding site [chemical binding]; other site
323848000435	Subunit I/VIIa interface [polypeptide binding]; other site
323848000436	Subunit I/VIa interface [polypeptide binding]; other site
323848000437	Dimer interface; other site
323848000438	Putative water exit pathway; other site
323848000439	Binuclear center (heme a3/CuB) [ion binding]; other site
323848000440	K-pathway; other site
323848000441	Subunit I/Vb interface [polypeptide binding]; other site
323848000442	Putative proton exit pathway; other site
323848000443	Subunit I/VIb interface; other site
323848000444	Subunit I/VIc interface [polypeptide binding]; other site
323848000445	Electron transfer pathway; other site
323848000446	Subunit I/VIIIb interface [polypeptide binding]; other site
323848000447	Subunit I/VIIb interface [polypeptide binding]; other site
323848000448	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240
323848000449	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
323848000450	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
323848000451	Subunit III/VIIa interface [polypeptide binding]; other site
323848000452	Phospholipid binding site [chemical binding]; other site
323848000453	Subunit I/III interface [polypeptide binding]; other site
323848000454	Subunit III/VIb interface [polypeptide binding]; other site
323848000455	Subunit III/VIa interface; other site
323848000456	Subunit III/Vb interface [polypeptide binding]; other site
323848000457	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
323848000458	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
323848000459	UbiA prenyltransferase family; Region: UbiA; cl00337
323848000460	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
323848000461	Cu(I) binding site [ion binding]; other site
323848000462	FAD binding domain; Region: FAD_binding_4; pfam01565
323848000463	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
323848000464	BON domain; Region: BON; cl02771
323848000465	BON domain; Region: BON; cl02771
323848000466	Uncharacterised protein family UPF0102; Region: UPF0102; cl00516
323848000467	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
323848000468	Predicted methyltransferases [General function prediction only]; Region: COG0313
323848000469	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
323848000470	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
323848000471	catalytic core [active]
323848000472	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959
323848000473	potassium uptake protein; Region: kup; TIGR00794
323848000474	K+ potassium transporter; Region: K_trans; cl01227
323848000475	CHASE domain; Region: CHASE; cl01369
323848000476	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
323848000477	PAS fold; Region: PAS_4; pfam08448
323848000478	PAS domain S-box; Region: sensory_box; TIGR00229
323848000479	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848000480	putative active site [active]
323848000481	heme pocket [chemical binding]; other site
323848000482	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848000483	metal binding site [ion binding]; metal-binding site
323848000484	active site
323848000485	I-site; other site
323848000486	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848000487	exonuclease subunit SbcD; Provisional; Region: PRK10966
323848000488	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
323848000489	active site
323848000490	metal binding site [ion binding]; metal-binding site
323848000491	DNA binding site [nucleotide binding]
323848000492	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
323848000493	exonuclease subunit SbcC; Provisional; Region: PRK10246
323848000494	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
323848000495	Walker A/P-loop; other site
323848000496	ATP binding site [chemical binding]; other site
323848000497	Q-loop/lid; other site
323848000498	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
323848000499	ABC transporter signature motif; other site
323848000500	Walker B; other site
323848000501	D-loop; other site
323848000502	H-loop/switch region; other site
323848000503	Cytochrome c; Region: Cytochrom_C; cl11414
323848000504	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
323848000505	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
323848000506	active site
323848000507	metal binding site [ion binding]; metal-binding site
323848000508	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
323848000509	putative acyl-acceptor binding pocket; other site
323848000510	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
323848000511	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
323848000512	substrate binding site [chemical binding]; other site
323848000513	ATP binding site [chemical binding]; other site
323848000514	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
323848000515	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613
323848000516	tetramer interface [polypeptide binding]; other site
323848000517	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848000518	catalytic residue [active]
323848000519	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
323848000520	dimer interface [polypeptide binding]; other site
323848000521	catalytic triad [active]
323848000522	peroxidatic and resolving cysteines [active]
323848000523	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
323848000524	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613
323848000525	tetramer interface [polypeptide binding]; other site
323848000526	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848000527	catalytic residue [active]
323848000528	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848
323848000529	lipoyl attachment site [posttranslational modification]; other site
323848000530	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
323848000531	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
323848000532	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848000533	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
323848000534	Glutamate-cysteine ligase; Region: GshA; pfam08886
323848000535	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
323848000536	glutathione synthetase; Provisional; Region: PRK05246
323848000537	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
323848000538	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848000539	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006
323848000540	active pocket/dimerization site; other site
323848000541	active site
323848000542	phosphorylation site [posttranslational modification]
323848000543	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
323848000544	dimerization domain swap beta strand [polypeptide binding]; other site
323848000545	regulatory protein interface [polypeptide binding]; other site
323848000546	active site
323848000547	regulatory phosphorylation site [posttranslational modification]; other site
323848000548	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
323848000549	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
323848000550	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
323848000551	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
323848000552	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
323848000553	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
323848000554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848000555	S-adenosylmethionine binding site [chemical binding]; other site
323848000556	muropeptide transporter; Reviewed; Region: ampG; PRK11902
323848000557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
323848000558	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
323848000559	putative active site [active]
323848000560	putative DNA binding site [nucleotide binding]; other site
323848000561	putative phosphate binding site [ion binding]; other site
323848000562	putative catalytic site [active]
323848000563	metal binding site A [ion binding]; metal-binding site
323848000564	putative AP binding site [nucleotide binding]; other site
323848000565	putative metal binding site B [ion binding]; other site
323848000566	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
323848000567	Late embryogenesis abundant protein; Region: LEA_2; cl12118
323848000568	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
323848000569	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
323848000570	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323848000571	catalytic residue [active]
323848000572	Phosphopantetheine attachment site; Region: PP-binding; cl09936
323848000573	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
323848000574	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848000575	NAD(P) binding site [chemical binding]; other site
323848000576	active site
323848000577	acyl-CoA synthetase; Validated; Region: PRK09192
323848000578	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848000579	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
323848000580	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
323848000581	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
323848000582	[2Fe-2S] cluster binding site [ion binding]; other site
323848000583	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
323848000584	alpha subunit interface [polypeptide binding]; other site
323848000585	active site
323848000586	substrate binding site [chemical binding]; other site
323848000587	Fe binding site [ion binding]; other site
323848000588	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
323848000589	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
323848000590	substrate binding pocket [chemical binding]; other site
323848000591	chain length determination region; other site
323848000592	substrate-Mg2+ binding site; other site
323848000593	catalytic residues [active]
323848000594	aspartate-rich region 1; other site
323848000595	active site lid residues [active]
323848000596	aspartate-rich region 2; other site
323848000597	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
323848000598	TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007
323848000599	TPP-binding site; other site
323848000600	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
323848000601	PYR/PP interface [polypeptide binding]; other site
323848000602	dimer interface [polypeptide binding]; other site
323848000603	TPP binding site [chemical binding]; other site
323848000604	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
323848000605	Uncharacterized ACR, COG1469; Region: DUF198; cl00642
323848000606	transcriptional regulator EpsA; Region: EpsA; TIGR03020
323848000607	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
323848000608	DNA binding residues [nucleotide binding]
323848000609	dimerization interface [polypeptide binding]; other site
323848000610	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
323848000611	Bacterial sugar transferase; Region: Bac_transf; cl00939
323848000612	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051
323848000613	peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925
323848000614	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
323848000615	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
323848000616	SLBB domain; Region: SLBB; pfam10531
323848000617	chain length determinant protein EpsF; Region: EpsF; TIGR03017
323848000618	Chain length determinant protein; Region: Wzz; cl01623
323848000619	Chain length determinant protein; Region: Wzz; cl01623
323848000620	chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029
323848000621	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
323848000622	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
323848000623	VanZ like family; Region: VanZ; cl01971
323848000624	eight transmembrane protein EpsH (proposed exosortase); Region: 8TM_EpsH; cl10495
323848000625	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
323848000626	Protein of unknown function (DUF3485); Region: DUF3485; cl11827
323848000627	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
323848000628	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
323848000629	O-Antigen ligase; Region: Wzy_C; cl04850
323848000630	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323848000631	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
323848000632	Heparinase II/III-like protein; Region: Hepar_II_III; cl02215
323848000633	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848000634	S-adenosylmethionine binding site [chemical binding]; other site
323848000635	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323848000636	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
323848000637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848000638	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817
323848000639	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
323848000640	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848000641	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
323848000642	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
323848000643	active site
323848000644	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
323848000645	homodimer interface [polypeptide binding]; other site
323848000646	UDP-glucose 4-epimerase; Region: PLN02240
323848000647	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
323848000648	NAD binding site [chemical binding]; other site
323848000649	homodimer interface [polypeptide binding]; other site
323848000650	active site
323848000651	substrate binding site [chemical binding]; other site
323848000652	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
323848000653	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
323848000654	Substrate binding site [chemical binding]; other site
323848000655	Cupin domain; Region: Cupin_2; cl09118
323848000656	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
323848000657	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323848000658	RNA binding surface [nucleotide binding]; other site
323848000659	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
323848000660	active site
323848000661	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
323848000662	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
323848000663	NAD binding site [chemical binding]; other site
323848000664	substrate binding site [chemical binding]; other site
323848000665	homodimer interface [polypeptide binding]; other site
323848000666	active site
323848000667	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
323848000668	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
323848000669	NADP binding site [chemical binding]; other site
323848000670	active site
323848000671	putative substrate binding site [chemical binding]; other site
323848000672	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
323848000673	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
323848000674	substrate binding site [chemical binding]; other site
323848000675	tetramer interface [polypeptide binding]; other site
323848000676	Cupin domain; Region: Cupin_2; cl09118
323848000677	Fatty acid desaturase; Region: FA_desaturase; pfam00487
323848000678	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060
323848000679	putative di-iron ligands [ion binding]; other site
323848000680	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
323848000681	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
323848000682	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
323848000683	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
323848000684	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
323848000685	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
323848000686	NAD binding site [chemical binding]; other site
323848000687	substrate binding site [chemical binding]; other site
323848000688	homodimer interface [polypeptide binding]; other site
323848000689	active site
323848000690	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848000691	TPR motif; other site
323848000692	binding surface
323848000693	hydrolase, ortholog 1, exosortase system type 1 associated; Region: hydr1_PEP; TIGR03100
323848000694	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
323848000695	hydrolase, ortholog 2, exosortase system type 1 associated; Region: hydr2_PEP; TIGR03101
323848000696	Phosphopantetheine attachment site; Region: PP-binding; cl09936
323848000697	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
323848000698	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
323848000699	Ligand binding site [chemical binding]; other site
323848000700	Putative Catalytic site [active]
323848000701	DXD motif; other site
323848000702	GtrA-like protein; Region: GtrA; cl00971
323848000703	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961
323848000704	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
323848000705	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
323848000706	Ligand binding site [chemical binding]; other site
323848000707	Putative Catalytic site [active]
323848000708	DXD motif; other site
323848000709	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
323848000710	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848000711	S-adenosylmethionine binding site [chemical binding]; other site
323848000712	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
323848000713	dimer interface [polypeptide binding]; other site
323848000714	substrate binding site [chemical binding]; other site
323848000715	metal binding site [ion binding]; metal-binding site
323848000716	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
323848000717	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
323848000718	Phosphopantetheine attachment site; Region: PP-binding; cl09936
323848000719	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
323848000720	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
323848000721	putative trimer interface [polypeptide binding]; other site
323848000722	putative CoA binding site [chemical binding]; other site
323848000723	WbqC-like protein family; Region: WbqC; pfam08889
323848000724	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
323848000725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848000726	S-adenosylmethionine binding site [chemical binding]; other site
323848000727	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
323848000728	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
323848000729	inhibitor-cofactor binding pocket; inhibition site
323848000730	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848000731	catalytic residue [active]
323848000732	PEP-CTERM/exosortase 1-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063
323848000733	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
323848000734	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
323848000735	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323848000736	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848000737	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
323848000738	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
323848000739	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848000740	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
323848000741	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
323848000742	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323848000743	active site
323848000744	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
323848000745	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027
323848000746	Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265
323848000747	ligand-binding site [chemical binding]; other site
323848000748	O-Antigen ligase; Region: Wzy_C; cl04850
323848000749	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
323848000750	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
323848000751	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
323848000752	Protein of unknown function (DUF3565); Region: DUF3565; pfam12088
323848000753	Domain of unknown function (DUF1971); Region: DUF1971; cl01451
323848000754	ATP synthase I chain; Region: ATP_synt_I; cl09170
323848000755	ATP synthase A chain; Region: ATP-synt_A; cl00413
323848000756	ATP synthase subunit C; Region: ATP-synt_C; cl00466
323848000757	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
323848000758	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
323848000759	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
323848000760	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
323848000761	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
323848000762	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
323848000763	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
323848000764	beta subunit interaction interface [polypeptide binding]; other site
323848000765	Walker A motif; other site
323848000766	ATP binding site [chemical binding]; other site
323848000767	Walker B motif; other site
323848000768	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
323848000769	ATP synthase; Region: ATP-synt; cl00365
323848000770	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
323848000771	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
323848000772	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
323848000773	alpha subunit interaction interface [polypeptide binding]; other site
323848000774	Walker A motif; other site
323848000775	ATP binding site [chemical binding]; other site
323848000776	Walker B motif; other site
323848000777	inhibitor binding site; inhibition site
323848000778	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
323848000779	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
323848000780	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
323848000781	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
323848000782	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
323848000783	Substrate binding site [chemical binding]; other site
323848000784	Mg++ binding site [ion binding]; other site
323848000785	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
323848000786	active site
323848000787	substrate binding site [chemical binding]; other site
323848000788	CoA binding site [chemical binding]; other site
323848000789	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
323848000790	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714
323848000791	glutaminase active site [active]
323848000792	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
323848000793	dimer interface [polypeptide binding]; other site
323848000794	active site
323848000795	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
323848000796	dimer interface [polypeptide binding]; other site
323848000797	active site
323848000798	rare lipoprotein A; Provisional; Region: PRK10672
323848000799	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
323848000800	Sporulation related domain; Region: SPOR; cl10051
323848000801	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
323848000802	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
323848000803	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
323848000804	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
323848000805	rod shape-determining protein MreD; Region: MreD; cl01087
323848000806	rod shape-determining protein MreC; Provisional; Region: PRK13922
323848000807	rod shape-determining protein MreC; Region: MreC; pfam04085
323848000808	rod shape-determining protein MreB; Provisional; Region: PRK13927
323848000809	Cell division protein FtsA; Region: FtsA; cl11496
323848000810	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
323848000811	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
323848000812	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
323848000813	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
323848000814	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
323848000815	GatB domain; Region: GatB_Yqey; cl11497
323848000816	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
323848000817	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
323848000818	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
323848000819	catalytic residues [active]
323848000820	SelR domain; Region: SelR; cl00369
323848000821	PAS fold; Region: PAS_4; pfam08448
323848000822	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848000823	putative active site [active]
323848000824	heme pocket [chemical binding]; other site
323848000825	PAS domain S-box; Region: sensory_box; TIGR00229
323848000826	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848000827	putative active site [active]
323848000828	heme pocket [chemical binding]; other site
323848000829	PAS domain S-box; Region: sensory_box; TIGR00229
323848000830	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848000831	putative active site [active]
323848000832	heme pocket [chemical binding]; other site
323848000833	PAS fold; Region: PAS_4; pfam08448
323848000834	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848000835	putative active site [active]
323848000836	heme pocket [chemical binding]; other site
323848000837	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848000838	metal binding site [ion binding]; metal-binding site
323848000839	active site
323848000840	I-site; other site
323848000841	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848000842	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
323848000843	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
323848000844	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848000845	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848000846	binding surface
323848000847	TPR motif; other site
323848000848	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
323848000849	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
323848000850	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
323848000851	putative binding surface; other site
323848000852	active site
323848000853	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323848000854	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848000855	ATP binding site [chemical binding]; other site
323848000856	Mg2+ binding site [ion binding]; other site
323848000857	G-X-G motif; other site
323848000858	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
323848000859	Response regulator receiver domain; Region: Response_reg; pfam00072
323848000860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848000861	active site
323848000862	phosphorylation site [posttranslational modification]
323848000863	intermolecular recognition site; other site
323848000864	dimerization interface [polypeptide binding]; other site
323848000865	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
323848000866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848000867	active site
323848000868	phosphorylation site [posttranslational modification]
323848000869	intermolecular recognition site; other site
323848000870	dimerization interface [polypeptide binding]; other site
323848000871	CheB methylesterase; Region: CheB_methylest; pfam01339
323848000872	Response regulator receiver domain; Region: Response_reg; pfam00072
323848000873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848000874	active site
323848000875	phosphorylation site [posttranslational modification]
323848000876	intermolecular recognition site; other site
323848000877	dimerization interface [polypeptide binding]; other site
323848000878	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
323848000879	GAF domain; Region: GAF; cl00853
323848000880	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848000881	metal binding site [ion binding]; metal-binding site
323848000882	active site
323848000883	I-site; other site
323848000884	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848000885	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
323848000886	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
323848000887	NADP binding site [chemical binding]; other site
323848000888	substrate binding pocket [chemical binding]; other site
323848000889	active site
323848000890	Uncharacterized conserved protein [Function unknown]; Region: COG1565
323848000891	Uncharacterized ACR, COG1565; Region: DUF185; pfam02636
323848000892	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623
323848000893	FOG: CBS domain [General function prediction only]; Region: COG0517
323848000894	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
323848000895	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
323848000896	Cysteine-rich domain; Region: CCG; pfam02754
323848000897	Cysteine-rich domain; Region: CCG; pfam02754
323848000898	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
323848000899	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
323848000900	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323848000901	catalytic residue [active]
323848000902	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
323848000903	diiron binding motif [ion binding]; other site
323848000904	OsmC-like protein; Region: OsmC; cl00767
323848000905	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
323848000906	putative active site [active]
323848000907	Cytochrome c; Region: Cytochrom_C; cl11414
323848000908	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
323848000909	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955
323848000910	catalytic residues [active]
323848000911	Dehydratase family; Region: ILVD_EDD; cl00340
323848000912	dihydroxy-acid dehydratase; Region: ilvD; TIGR00110
323848000913	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
323848000914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848000915	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
323848000916	putative lipid binding site [chemical binding]; other site
323848000917	Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
323848000918	Protein of unknown function, DUF393; Region: DUF393; cl01136
323848000919	Dihydroorotase [Nucleotide transport and metabolism]; Region: PyrC; COG0418
323848000920	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
323848000921	active site
323848000922	substrate binding pocket [chemical binding]; other site
323848000923	dimer interface [polypeptide binding]; other site
323848000924	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
323848000925	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848000926	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
323848000927	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
323848000928	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
323848000929	homodimer interface [polypeptide binding]; other site
323848000930	NADP binding site [chemical binding]; other site
323848000931	substrate binding site [chemical binding]; other site
323848000932	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
323848000933	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
323848000934	dimer interface [polypeptide binding]; other site
323848000935	TPP-binding site [chemical binding]; other site
323848000936	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
323848000937	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
323848000938	E3 interaction surface; other site
323848000939	lipoyl attachment site [posttranslational modification]; other site
323848000940	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
323848000941	e3 binding domain; Region: E3_binding; pfam02817
323848000942	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
323848000943	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
323848000944	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
323848000945	active site
323848000946	(T/H)XGH motif; other site
323848000947	Domain of unknown function DUF143; Region: DUF143; cl00519
323848000948	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679
323848000949	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
323848000950	active site
323848000951	dimer interface [polypeptide binding]; other site
323848000952	ribonuclease G; Provisional; Region: PRK11712
323848000953	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
323848000954	homodimer interface [polypeptide binding]; other site
323848000955	oligonucleotide binding site [chemical binding]; other site
323848000956	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
323848000957	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
323848000958	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
323848000959	Walker A/P-loop; other site
323848000960	ATP binding site [chemical binding]; other site
323848000961	Q-loop/lid; other site
323848000962	ABC transporter signature motif; other site
323848000963	Walker B; other site
323848000964	D-loop; other site
323848000965	H-loop/switch region; other site
323848000966	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
323848000967	FtsX-like permease family; Region: FtsX; pfam02687
323848000968	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
323848000969	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
323848000970	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
323848000971	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
323848000972	hypothetical protein; Validated; Region: PRK08223
323848000973	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848000974	ATP binding site [chemical binding]; other site
323848000975	substrate interface [chemical binding]; other site
323848000976	hypothetical protein; Provisional; Region: PRK07877
323848000977	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
323848000978	dimer interface [polypeptide binding]; other site
323848000979	hypothetical protein; Provisional; Region: PRK14852
323848000980	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
323848000981	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848000982	TPR motif; other site
323848000983	binding surface
323848000984	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848000985	binding surface
323848000986	TPR motif; other site
323848000987	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848000988	binding surface
323848000989	TPR motif; other site
323848000990	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848000991	binding surface
323848000992	TPR motif; other site
323848000993	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848000994	TPR motif; other site
323848000995	binding surface
323848000996	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848000997	binding surface
323848000998	TPR motif; other site
323848000999	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637
323848001000	active site
323848001001	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
323848001002	putative catalytic residue [active]
323848001003	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
323848001004	N-acetylglutamate synthase; Validated; Region: PRK05279
323848001005	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an N-...; Region: AAK_NAGS-ABP; cd04237
323848001006	putative feedback inhibition sensing region; other site
323848001007	putative nucleotide binding site [chemical binding]; other site
323848001008	putative substrate binding site [chemical binding]; other site
323848001009	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323848001010	Coenzyme A binding pocket [chemical binding]; other site
323848001011	Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104
323848001012	polyphosphate kinase; Provisional; Region: PRK05443
323848001013	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
323848001014	putative domain interface [polypeptide binding]; other site
323848001015	putative active site [active]
323848001016	catalytic site [active]
323848001017	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
323848001018	putative domain interface [polypeptide binding]; other site
323848001019	putative active site [active]
323848001020	catalytic site [active]
323848001021	Uncharacterized conserved protein [Function unknown]; Region: COG3025
323848001022	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
323848001023	putative active site [active]
323848001024	putative metal binding residues [ion binding]; other site
323848001025	signature motif; other site
323848001026	putative triphosphate binding site [ion binding]; other site
323848001027	CHAD domain; Region: CHAD; cl10506
323848001028	hypothetical protein; Provisional; Region: PRK08185
323848001029	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947
323848001030	intersubunit interface [polypeptide binding]; other site
323848001031	active site
323848001032	zinc binding site [ion binding]; other site
323848001033	Na+ binding site [ion binding]; other site
323848001034	pyruvate kinase; Provisional; Region: PRK05826
323848001035	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
323848001036	domain interfaces; other site
323848001037	active site
323848001038	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
323848001039	substrate binding site [chemical binding]; other site
323848001040	hinge regions; other site
323848001041	ADP binding site [chemical binding]; other site
323848001042	catalytic site [active]
323848001043	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848001044	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
323848001045	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
323848001046	transketolase; Reviewed; Region: PRK12753
323848001047	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
323848001048	TPP-binding site [chemical binding]; other site
323848001049	dimer interface [polypeptide binding]; other site
323848001050	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
323848001051	PYR/PP interface [polypeptide binding]; other site
323848001052	dimer interface [polypeptide binding]; other site
323848001053	TPP binding site [chemical binding]; other site
323848001054	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
323848001055	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
323848001056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848001057	active site
323848001058	phosphorylation site [posttranslational modification]
323848001059	intermolecular recognition site; other site
323848001060	dimerization interface [polypeptide binding]; other site
323848001061	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848001062	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
323848001063	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
323848001064	dimerization interface [polypeptide binding]; other site
323848001065	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
323848001066	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848001067	ATP binding site [chemical binding]; other site
323848001068	Mg2+ binding site [ion binding]; other site
323848001069	G-X-G motif; other site
323848001070	16S rRNA methyltransferase B; Provisional; Region: PRK10901
323848001071	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848001072	S-adenosylmethionine binding site [chemical binding]; other site
323848001073	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
323848001074	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
323848001075	putative active site [active]
323848001076	substrate binding site [chemical binding]; other site
323848001077	putative cosubstrate binding site; other site
323848001078	catalytic site [active]
323848001079	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
323848001080	substrate binding site [chemical binding]; other site
323848001081	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
323848001082	active site
323848001083	catalytic residues [active]
323848001084	metal binding site [ion binding]; metal-binding site
323848001085	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
323848001086	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
323848001087	DNA topoisomerase III; Validated; Region: PRK08173
323848001088	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362
323848001089	active site
323848001090	putative interdomain interaction site [polypeptide binding]; other site
323848001091	putative metal-binding site [ion binding]; other site
323848001092	putative nucleotide binding site [chemical binding]; other site
323848001093	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
323848001094	domain I; other site
323848001095	DNA binding groove [nucleotide binding]
323848001096	phosphate binding site [ion binding]; other site
323848001097	domain II; other site
323848001098	domain III; other site
323848001099	nucleotide binding site [chemical binding]; other site
323848001100	catalytic site [active]
323848001101	domain IV; other site
323848001102	Phosphopantetheine attachment site; Region: PP-binding; cl09936
323848001103	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
323848001104	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
323848001105	dimer interface [polypeptide binding]; other site
323848001106	active site
323848001107	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323848001108	active site
323848001109	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
323848001110	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
323848001111	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
323848001112	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
323848001113	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
323848001114	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
323848001115	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
323848001116	ligand binding site [chemical binding]; other site
323848001117	tetramer interface [polypeptide binding]; other site
323848001118	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
323848001119	active site
323848001120	motif I; other site
323848001121	motif II; other site
323848001122	NeuB family; Region: NeuB; cl00496
323848001123	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
323848001124	ligand binding site [chemical binding]; other site
323848001125	tetramer interface [polypeptide binding]; other site
323848001126	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
323848001127	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848001128	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
323848001129	flagellin modification protein A; Provisional; Region: PRK09186
323848001130	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848001131	NAD(P) binding site [chemical binding]; other site
323848001132	active site
323848001133	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
323848001134	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
323848001135	putative active site [active]
323848001136	catalytic site [active]
323848001137	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
323848001138	active site
323848001139	Protein of unknown function (DUF2843); Region: DUF2843; pfam11004
323848001140	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848001141	O-Antigen ligase; Region: Wzy_C; cl04850
323848001142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848001143	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848001144	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961
323848001145	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
323848001146	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
323848001147	catalytic core [active]
323848001148	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
323848001149	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228
323848001150	nucleotide binding site/active site [active]
323848001151	HIT family signature motif; other site
323848001152	catalytic residue [active]
323848001153	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
323848001154	active site
323848001155	metal binding site [ion binding]; metal-binding site
323848001156	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
323848001157	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
323848001158	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
323848001159	motif II; other site
323848001160	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
323848001161	extended (e) SDRs; Region: SDR_e; cd08946
323848001162	NAD(P) binding site [chemical binding]; other site
323848001163	active site
323848001164	substrate binding site [chemical binding]; other site
323848001165	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
323848001166	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848001167	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
323848001168	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
323848001169	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
323848001170	Ligand binding site [chemical binding]; other site
323848001171	oligomer interface [polypeptide binding]; other site
323848001172	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
323848001173	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
323848001174	Probable Catalytic site [active]
323848001175	metal binding site [ion binding]; metal-binding site
323848001176	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
323848001177	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
323848001178	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
323848001179	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
323848001180	transcriptional regulator PhoU; Provisional; Region: PRK11115
323848001181	PhoU domain; Region: PhoU; pfam01895
323848001182	PhoU domain; Region: PhoU; pfam01895
323848001183	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
323848001184	tetramer (dimer of dimers) interface [polypeptide binding]; other site
323848001185	active site
323848001186	dimer interface [polypeptide binding]; other site
323848001187	threonine dehydratase; Reviewed; Region: PRK09224
323848001188	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
323848001189	tetramer interface [polypeptide binding]; other site
323848001190	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848001191	catalytic residue [active]
323848001192	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
323848001193	putative Ile/Val binding site [chemical binding]; other site
323848001194	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
323848001195	putative Ile/Val binding site [chemical binding]; other site
323848001196	Protein of unknown function (DUF1597); Region: DUF1597; pfam07642
323848001197	Protein of unknown function (DUF1597); Region: DUF1597; pfam07642
323848001198	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323848001199	Coenzyme A binding pocket [chemical binding]; other site
323848001200	adenylosuccinate synthetase; Provisional; Region: PRK01117
323848001201	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108
323848001202	GDP-binding site [chemical binding]; other site
323848001203	ACT binding site; other site
323848001204	IMP binding site; other site
323848001205	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
323848001206	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
323848001207	dimer interface [polypeptide binding]; other site
323848001208	motif 1; other site
323848001209	active site
323848001210	motif 2; other site
323848001211	motif 3; other site
323848001212	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275
323848001213	FtsH protease regulator HflC; Provisional; Region: PRK11029
323848001214	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
323848001215	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
323848001216	HflK protein; Region: hflK; TIGR01933
323848001217	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
323848001218	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
323848001219	HflX subfamily.  A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily.  The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
323848001220	G1 box; other site
323848001221	GTP/Mg2+ binding site [chemical binding]; other site
323848001222	Switch I region; other site
323848001223	G2 box; other site
323848001224	G3 box; other site
323848001225	Switch II region; other site
323848001226	G4 box; other site
323848001227	G5 box; other site
323848001228	Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
323848001229	Sm1 motif; other site
323848001230	intra - hexamer interaction site; other site
323848001231	inter - hexamer interaction site [polypeptide binding]; other site
323848001232	nucleotide binding pocket [chemical binding]; other site
323848001233	Sm2 motif; other site
323848001234	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
323848001235	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671
323848001236	putative active site [active]
323848001237	Ap4A binding site [chemical binding]; other site
323848001238	nudix motif; other site
323848001239	putative metal binding site [ion binding]; other site
323848001240	prolyl-tRNA synthetase; Provisional; Region: PRK09194
323848001241	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779
323848001242	dimer interface [polypeptide binding]; other site
323848001243	motif 1; other site
323848001244	active site
323848001245	motif 2; other site
323848001246	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334
323848001247	putative deacylase active site [active]
323848001248	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
323848001249	active site
323848001250	motif 3; other site
323848001251	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861
323848001252	anticodon binding site; other site
323848001253	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966
323848001254	catalytic residues [active]
323848001255	ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214
323848001256	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
323848001257	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848001258	2-isopropylmalate synthase; Validated; Region: PRK00915
323848001259	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
323848001260	active site
323848001261	catalytic residues [active]
323848001262	metal binding site [ion binding]; metal-binding site
323848001263	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
323848001264	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
323848001265	Cu(I) binding site [ion binding]; other site
323848001266	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
323848001267	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
323848001268	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
323848001269	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
323848001270	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
323848001271	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
323848001272	D-pathway; other site
323848001273	Putative ubiquinol binding site [chemical binding]; other site
323848001274	Low-spin heme (heme b) binding site [chemical binding]; other site
323848001275	Putative water exit pathway; other site
323848001276	Binuclear center (heme o3/CuB) [ion binding]; other site
323848001277	K-pathway; other site
323848001278	Putative proton exit pathway; other site
323848001279	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
323848001280	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
323848001281	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
323848001282	active site
323848001283	zinc binding site [ion binding]; other site
323848001284	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
323848001285	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
323848001286	active site
323848001287	zinc binding site [ion binding]; other site
323848001288	PEP-CTERM motif; Region: VPEP; pfam07589
323848001289	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
323848001290	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
323848001291	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
323848001292	phosphoglucomutase; Validated; Region: PRK07564
323848001293	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
323848001294	active site
323848001295	substrate binding site [chemical binding]; other site
323848001296	metal binding site [ion binding]; metal-binding site
323848001297	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
323848001298	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
323848001299	TPP-binding site [chemical binding]; other site
323848001300	dimer interface [polypeptide binding]; other site
323848001301	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
323848001302	PYR/PP interface [polypeptide binding]; other site
323848001303	dimer interface [polypeptide binding]; other site
323848001304	TPP binding site [chemical binding]; other site
323848001305	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
323848001306	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
323848001307	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
323848001308	active site
323848001309	dimer interface [polypeptide binding]; other site
323848001310	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
323848001311	dimer interface [polypeptide binding]; other site
323848001312	active site
323848001313	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
323848001314	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
323848001315	PEP-CTERM motif; Region: VPEP; pfam07589
323848001316	ketol-acid reductoisomerase; Provisional; Region: PRK05479
323848001317	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848001318	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
323848001319	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
323848001320	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
323848001321	putative valine binding site [chemical binding]; other site
323848001322	dimer interface [polypeptide binding]; other site
323848001323	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
323848001324	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
323848001325	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
323848001326	PYR/PP interface [polypeptide binding]; other site
323848001327	dimer interface [polypeptide binding]; other site
323848001328	TPP binding site [chemical binding]; other site
323848001329	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
323848001330	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
323848001331	TPP-binding site [chemical binding]; other site
323848001332	dimer interface [polypeptide binding]; other site
323848001333	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
323848001334	metal binding site 2 [ion binding]; metal-binding site
323848001335	putative DNA binding helix; other site
323848001336	metal binding site 1 [ion binding]; metal-binding site
323848001337	dimer interface [polypeptide binding]; other site
323848001338	structural Zn2+ binding site [ion binding]; other site
323848001339	SmpA / OmlA family; Region: SmpA_OmlA; cl01095
323848001340	dihydrodipicolinate reductase; Provisional; Region: PRK00048
323848001341	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848001342	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
323848001343	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
323848001344	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
323848001345	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
323848001346	catalytic site [active]
323848001347	subunit interface [polypeptide binding]; other site
323848001348	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
323848001349	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323848001350	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848001351	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
323848001352	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323848001353	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848001354	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
323848001355	IMP binding site; other site
323848001356	dimer interface [polypeptide binding]; other site
323848001357	interdomain contacts; other site
323848001358	partial ornithine binding site; other site
323848001359	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
323848001360	domain; Region: GreA_GreB_N; pfam03449
323848001361	C-term; Region: GreA_GreB; pfam01272
323848001362	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
323848001363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848001364	FtsH Extracellular; Region: FtsH_ext; pfam06480
323848001365	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
323848001366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848001367	Walker A motif; other site
323848001368	ATP binding site [chemical binding]; other site
323848001369	Walker B motif; other site
323848001370	arginine finger; other site
323848001371	Peptidase family M41; Region: Peptidase_M41; pfam01434
323848001372	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
323848001373	dihydropteroate synthase; Region: DHPS; TIGR01496
323848001374	substrate binding pocket [chemical binding]; other site
323848001375	dimer interface [polypeptide binding]; other site
323848001376	inhibitor binding site; inhibition site
323848001377	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
323848001378	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802
323848001379	active site
323848001380	substrate binding site [chemical binding]; other site
323848001381	metal binding site [ion binding]; metal-binding site
323848001382	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
323848001383	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
323848001384	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667
323848001385	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
323848001386	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
323848001387	active site
323848001388	dimer interface [polypeptide binding]; other site
323848001389	motif 1; other site
323848001390	motif 2; other site
323848001391	motif 3; other site
323848001392	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
323848001393	anticodon binding site; other site
323848001394	translation initiation factor IF-3; Region: infC; TIGR00168
323848001395	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
323848001396	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
323848001397	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
323848001398	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
323848001399	23S rRNA binding site [nucleotide binding]; other site
323848001400	L21 binding site [polypeptide binding]; other site
323848001401	L13 binding site [polypeptide binding]; other site
323848001402	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
323848001403	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
323848001404	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
323848001405	dimer interface [polypeptide binding]; other site
323848001406	motif 1; other site
323848001407	active site
323848001408	motif 2; other site
323848001409	motif 3; other site
323848001410	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
323848001411	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
323848001412	putative tRNA-binding site [nucleotide binding]; other site
323848001413	B3/4 domain; Region: B3_4; cl11458
323848001414	tRNA synthetase B5 domain; Region: B5; cl08394
323848001415	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
323848001416	dimer interface [polypeptide binding]; other site
323848001417	motif 1; other site
323848001418	motif 3; other site
323848001419	motif 2; other site
323848001420	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
323848001421	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
323848001422	IHF dimer interface [polypeptide binding]; other site
323848001423	IHF - DNA interface [nucleotide binding]; other site
323848001424	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
323848001425	DNA binding residues [nucleotide binding]
323848001426	Survival protein SurE; Region: SurE; cl00448
323848001427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848001428	S-adenosylmethionine binding site [chemical binding]; other site
323848001429	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
323848001430	putative peptidoglycan binding site; other site
323848001431	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
323848001432	Peptidase family M23; Region: Peptidase_M23; pfam01551
323848001433	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
323848001434	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
323848001435	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323848001436	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
323848001437	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
323848001438	DNA binding residues [nucleotide binding]
323848001439	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454
323848001440	apolar tunnel; other site
323848001441	heme binding site [chemical binding]; other site
323848001442	dimerization interface [polypeptide binding]; other site
323848001443	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488
323848001444	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
323848001445	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
323848001446	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
323848001447	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
323848001448	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
323848001449	active site
323848001450	HIGH motif; other site
323848001451	dimer interface [polypeptide binding]; other site
323848001452	KMSKS motif; other site
323848001453	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
323848001454	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
323848001455	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296
323848001456	Walker A/P-loop; other site
323848001457	ATP binding site [chemical binding]; other site
323848001458	Q-loop/lid; other site
323848001459	ABC transporter signature motif; other site
323848001460	Walker B; other site
323848001461	D-loop; other site
323848001462	H-loop/switch region; other site
323848001463	TOBE-like domain; Region: TOBE_3; pfam12857
323848001464	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
323848001465	dimer interface [polypeptide binding]; other site
323848001466	conserved gate region; other site
323848001467	putative PBP binding loops; other site
323848001468	ABC-ATPase subunit interface; other site
323848001469	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
323848001470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
323848001471	dimer interface [polypeptide binding]; other site
323848001472	conserved gate region; other site
323848001473	putative PBP binding loops; other site
323848001474	ABC-ATPase subunit interface; other site
323848001475	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848001476	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
323848001477	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
323848001478	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This...; Region: Alpha_ANH_like_II; cd01993
323848001479	Ligand Binding Site [chemical binding]; other site
323848001480	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
323848001481	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
323848001482	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
323848001483	protein binding site [polypeptide binding]; other site
323848001484	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
323848001485	protein binding site [polypeptide binding]; other site
323848001486	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
323848001487	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
323848001488	HIGH motif; other site
323848001489	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323848001490	active site
323848001491	KMSKS motif; other site
323848001492	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
323848001493	tRNA binding surface [nucleotide binding]; other site
323848001494	Lipopolysaccharide-assembly; Region: LptE; cl01125
323848001495	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
323848001496	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
323848001497	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
323848001498	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
323848001499	putative catalytic cysteine [active]
323848001500	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
323848001501	E3 interaction surface; other site
323848001502	lipoyl attachment site [posttranslational modification]; other site
323848001503	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
323848001504	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848001505	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848001506	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
323848001507	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
323848001508	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
323848001509	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323848001510	catalytic residue [active]
323848001511	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848001512	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
323848001513	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
323848001514	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
323848001515	SurA N-terminal domain; Region: SurA_N; pfam09312
323848001516	PPIC-type PPIASE domain; Region: Rotamase; cl08278
323848001517	PPIC-type PPIASE domain; Region: Rotamase; cl08278
323848001518	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
323848001519	Organic solvent tolerance protein; Region: OstA_C; pfam04453
323848001520	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
323848001521	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
323848001522	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323848001523	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323848001524	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
323848001525	choline dehydrogenase; Validated; Region: PRK02106
323848001526	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848001527	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
323848001528	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
323848001529	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
323848001530	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
323848001531	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
323848001532	putative heme binding pocket [chemical binding]; other site
323848001533	Lipoxygenase; Region: Lipoxygenase; pfam00305
323848001534	Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816
323848001535	substrate binding site [chemical binding]; other site
323848001536	homodimer interface [polypeptide binding]; other site
323848001537	heme binding site [chemical binding]; other site
323848001538	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
323848001539	active site
323848001540	catalytic triad [active]
323848001541	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
323848001542	RNB domain; Region: RNB; pfam00773
323848001543	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
323848001544	Gram-negative bacterial tonB protein; Region: TonB; cl10048
323848001545	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
323848001546	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
323848001547	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
323848001548	shikimate binding site; other site
323848001549	NAD(P) binding site [chemical binding]; other site
323848001550	Transglycosylase; Region: Transgly; cl07896
323848001551	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
323848001552	MgtE intracellular N domain; Region: MgtE_N; cl15244
323848001553	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
323848001554	diaminopimelate decarboxylase; Region: lysA; TIGR01048
323848001555	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
323848001556	active site
323848001557	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
323848001558	substrate binding site [chemical binding]; other site
323848001559	catalytic residues [active]
323848001560	dimer interface [polypeptide binding]; other site
323848001561	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944
323848001562	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
323848001563	putative transposase OrfB; Reviewed; Region: PHA02517
323848001564	Integrase core domain; Region: rve; cl01316
323848001565	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848001566	Protein of unknown function DUF45; Region: DUF45; cl00636
323848001567	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
323848001568	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
323848001569	putative acyl-acceptor binding pocket; other site
323848001570	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
323848001571	active site
323848001572	motif I; other site
323848001573	motif II; other site
323848001574	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
323848001575	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
323848001576	glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388
323848001577	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
323848001578	dimer interface [polypeptide binding]; other site
323848001579	motif 1; other site
323848001580	active site
323848001581	motif 2; other site
323848001582	motif 3; other site
323848001583	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
323848001584	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
323848001585	putative active site [active]
323848001586	catalytic triad [active]
323848001587	putative dimer interface [polypeptide binding]; other site
323848001588	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323848001589	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848001590	ATP binding site [chemical binding]; other site
323848001591	Mg2+ binding site [ion binding]; other site
323848001592	G-X-G motif; other site
323848001593	putative peptidase; Provisional; Region: PRK11649
323848001594	Peptidase family M23; Region: Peptidase_M23; pfam01551
323848001595	Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217
323848001596	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
323848001597	Polymer-forming cytoskeletal; Region: Bactofilin; cl09137
323848001598	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
323848001599	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848001600	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
323848001601	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
323848001602	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
323848001603	23S rRNA interface [nucleotide binding]; other site
323848001604	L3 interface [polypeptide binding]; other site
323848001605	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate...; Region: PRK_like; cd02029
323848001606	Active site [active]
323848001607	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
323848001608	UvrD/REP helicase; Region: UvrD-helicase; cl14126
323848001609	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
323848001610	Phosphotransferase enzyme family; Region: APH; pfam01636
323848001611	putative active site [active]
323848001612	putative substrate binding site [chemical binding]; other site
323848001613	ATP binding site [chemical binding]; other site
323848001614	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
323848001615	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
323848001616	DNA polymerase I; Provisional; Region: PRK05755
323848001617	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
323848001618	active site
323848001619	metal binding site 1 [ion binding]; metal-binding site
323848001620	putative 5' ssDNA interaction site; other site
323848001621	metal binding site 3; metal-binding site
323848001622	metal binding site 2 [ion binding]; metal-binding site
323848001623	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
323848001624	putative DNA binding site [nucleotide binding]; other site
323848001625	putative metal binding site [ion binding]; other site
323848001626	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
323848001627	active site
323848001628	catalytic site [active]
323848001629	substrate binding site [chemical binding]; other site
323848001630	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
323848001631	active site
323848001632	DNA binding site [nucleotide binding]
323848001633	catalytic site [active]
323848001634	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
323848001635	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
323848001636	RimM N-terminal domain; Region: RimM; pfam01782
323848001637	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959
323848001638	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
323848001639	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
323848001640	Cytochrome c; Region: Cytochrom_C; cl11414
323848001641	Protein of unknown function, DUF; Region: DUF411; cl01142
323848001642	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
323848001643	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
323848001644	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
323848001645	Predicted membrane protein [Function unknown]; Region: COG2119
323848001646	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
323848001647	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
323848001648	Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811
323848001649	YGGT family; Region: YGGT; cl00508
323848001650	YGGT family; Region: YGGT; cl00508
323848001651	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
323848001652	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848001653	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
323848001654	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
323848001655	DNA binding site [nucleotide binding]
323848001656	catalytic residue [active]
323848001657	H2TH interface [polypeptide binding]; other site
323848001658	putative catalytic residues [active]
323848001659	turnover-facilitating residue; other site
323848001660	intercalation triad [nucleotide binding]; other site
323848001661	8OG recognition residue [nucleotide binding]; other site
323848001662	putative reading head residues; other site
323848001663	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
323848001664	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
323848001665	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
323848001666	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
323848001667	ABC-2 type transporter; Region: ABC2_membrane; cl11417
323848001668	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
323848001669	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848001670	Walker A/P-loop; other site
323848001671	ATP binding site [chemical binding]; other site
323848001672	Q-loop/lid; other site
323848001673	ABC transporter signature motif; other site
323848001674	Walker B; other site
323848001675	D-loop; other site
323848001676	H-loop/switch region; other site
323848001677	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
323848001678	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848001679	TPR motif; other site
323848001680	binding surface
323848001681	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848001682	binding surface
323848001683	TPR motif; other site
323848001684	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848001685	binding surface
323848001686	TPR motif; other site
323848001687	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
323848001688	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
323848001689	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
323848001690	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
323848001691	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
323848001692	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923
323848001693	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
323848001694	Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495
323848001695	5S rRNA interface [nucleotide binding]; other site
323848001696	CTC domain interface; other site
323848001697	L16 interface [polypeptide binding]; other site
323848001698	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
323848001699	putative active site [active]
323848001700	catalytic residue [active]
323848001701	GTP-binding protein YchF; Reviewed; Region: PRK09601
323848001702	YchF subfamily.  YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1.  Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
323848001703	G1 box; other site
323848001704	GTP/Mg2+ binding site [chemical binding]; other site
323848001705	Switch I region; other site
323848001706	G2 box; other site
323848001707	Switch II region; other site
323848001708	G3 box; other site
323848001709	G4 box; other site
323848001710	G5 box; other site
323848001711	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
323848001712	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848001713	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848001714	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
323848001715	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
323848001716	Protein of unknown function (DUF502); Region: DUF502; cl01107
323848001717	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
323848001718	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
323848001719	dimer interface [polypeptide binding]; other site
323848001720	anticodon binding site; other site
323848001721	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
323848001722	homodimer interface [polypeptide binding]; other site
323848001723	motif 1; other site
323848001724	active site
323848001725	motif 2; other site
323848001726	GAD domain; Region: GAD; pfam02938
323848001727	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
323848001728	motif 3; other site
323848001729	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
323848001730	nudix motif; other site
323848001731	Quinolinate synthetase A protein; Region: NadA; cl00420
323848001732	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
323848001733	putative catalytic site [active]
323848001734	putative metal binding site [ion binding]; other site
323848001735	putative phosphate binding site [ion binding]; other site
323848001736	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
323848001737	SUA5 domain; Region: SUA5; pfam03481
323848001738	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
323848001739	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
323848001740	motif II; other site
323848001741	Phosphate-starvation-inducible E; Region: PsiE; cl01264
323848001742	AIR carboxylase; Region: AIRC; cl00310
323848001743	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
323848001744	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848001745	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
323848001746	active site
323848001747	ATP binding site [chemical binding]; other site
323848001748	substrate binding site [chemical binding]; other site
323848001749	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
323848001750	EVE domain; Region: EVE; cl00728
323848001751	Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816
323848001752	substrate binding site [chemical binding]; other site
323848001753	homodimer interface [polypeptide binding]; other site
323848001754	heme binding site [chemical binding]; other site
323848001755	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
323848001756	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
323848001757	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
323848001758	putative active site [active]
323848001759	putative metal binding site [ion binding]; other site
323848001760	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
323848001761	putative active site [active]
323848001762	putative catalytic site [active]
323848001763	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323848001764	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848001765	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
323848001766	Cell division protein ZapA; Region: ZapA; cl01146
323848001767	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323848001768	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323848001769	N-terminal plug; other site
323848001770	ligand-binding site [chemical binding]; other site
323848001771	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
323848001772	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
323848001773	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848001774	Walker A/P-loop; other site
323848001775	ATP binding site [chemical binding]; other site
323848001776	Q-loop/lid; other site
323848001777	ABC transporter signature motif; other site
323848001778	Walker B; other site
323848001779	D-loop; other site
323848001780	H-loop/switch region; other site
323848001781	PAS fold; Region: PAS_7; pfam12860
323848001782	PAS domain S-box; Region: sensory_box; TIGR00229
323848001783	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848001784	putative active site [active]
323848001785	heme pocket [chemical binding]; other site
323848001786	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848001787	metal binding site [ion binding]; metal-binding site
323848001788	active site
323848001789	I-site; other site
323848001790	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848001791	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
323848001792	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
323848001793	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
323848001794	NAD(P) binding site [chemical binding]; other site
323848001795	homodimer interface [polypeptide binding]; other site
323848001796	substrate binding site [chemical binding]; other site
323848001797	active site
323848001798	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
323848001799	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine...; Region: GT_WbpL_WbcO_like; cd06854
323848001800	Mg++ binding site [ion binding]; other site
323848001801	putative catalytic motif [active]
323848001802	putative substrate binding site [chemical binding]; other site
323848001803	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
323848001804	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
323848001805	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323848001806	N-terminal plug; other site
323848001807	ligand-binding site [chemical binding]; other site
323848001808	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
323848001809	Chorismate lyase; Region: Chor_lyase; cl01230
323848001810	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
323848001811	motif II; other site
323848001812	Bacterial SH3 domain; Region: SH3_3; cl02551
323848001813	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
323848001814	dimerization interface [polypeptide binding]; other site
323848001815	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848001816	metal binding site [ion binding]; metal-binding site
323848001817	active site
323848001818	I-site; other site
323848001819	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
323848001820	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
323848001821	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323848001822	ATP binding site [chemical binding]; other site
323848001823	putative Mg++ binding site [ion binding]; other site
323848001824	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323848001825	nucleotide binding region [chemical binding]; other site
323848001826	ATP-binding site [chemical binding]; other site
323848001827	TRCF domain; Region: TRCF; pfam03461
323848001828	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
323848001829	DHH family; Region: DHH; pfam01368
323848001830	DHHA1 domain; Region: DHHA1; pfam02272
323848001831	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
323848001832	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
323848001833	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
323848001834	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
323848001835	Walker A/P-loop; other site
323848001836	ATP binding site [chemical binding]; other site
323848001837	Q-loop/lid; other site
323848001838	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
323848001839	ABC transporter signature motif; other site
323848001840	Walker B; other site
323848001841	D-loop; other site
323848001842	H-loop/switch region; other site
323848001843	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
323848001844	FtsZ protein binding site [polypeptide binding]; other site
323848001845	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
323848001846	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
323848001847	nucleotide binding pocket [chemical binding]; other site
323848001848	K-X-D-G motif; other site
323848001849	catalytic site [active]
323848001850	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
323848001851	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
323848001852	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
323848001853	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027
323848001854	Dimer interface [polypeptide binding]; other site
323848001855	BRCT sequence motif; other site
323848001856	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
323848001857	active site
323848001858	tetramer interface [polypeptide binding]; other site
323848001859	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
323848001860	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
323848001861	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
323848001862	active site
323848001863	catalytic residues [active]
323848001864	metal binding site [ion binding]; metal-binding site
323848001865	shikimate kinase; Reviewed; Region: aroK; PRK00131
323848001866	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464
323848001867	ADP binding site [chemical binding]; other site
323848001868	magnesium binding site [ion binding]; other site
323848001869	putative shikimate binding site; other site
323848001870	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
323848001871	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
323848001872	rRNA interaction site [nucleotide binding]; other site
323848001873	S8 interaction site; other site
323848001874	putative laminin-1 binding site; other site
323848001875	elongation factor Ts; Provisional; Region: tsf; PRK09377
323848001876	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
323848001877	Elongation factor TS; Region: EF_TS; pfam00889
323848001878	Elongation factor TS; Region: EF_TS; pfam00889
323848001879	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254
323848001880	putative nucleotide binding site [chemical binding]; other site
323848001881	uridine monophosphate binding site [chemical binding]; other site
323848001882	homohexameric interface [polypeptide binding]; other site
323848001883	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
323848001884	hinge region; other site
323848001885	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
323848001886	catalytic residue [active]
323848001887	putative FPP diphosphate  binding site; other site
323848001888	putative FPP binding hydrophobic cleft; other site
323848001889	dimer interface [polypeptide binding]; other site
323848001890	putative IPP diphosphate binding site; other site
323848001891	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
323848001892	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
323848001893	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
323848001894	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
323848001895	zinc metallopeptidase RseP; Provisional; Region: PRK10779
323848001896	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
323848001897	active site
323848001898	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
323848001899	protein binding site [polypeptide binding]; other site
323848001900	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
323848001901	protein binding site [polypeptide binding]; other site
323848001902	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
323848001903	putative substrate binding region [chemical binding]; other site
323848001904	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
323848001905	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
323848001906	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
323848001907	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
323848001908	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
323848001909	Surface antigen; Region: Bac_surface_Ag; cl03097
323848001910	Outer membrane protein (OmpH-like); Region: OmpH; cl08146
323848001911	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
323848001912	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
323848001913	RNA/DNA hybrid binding site [nucleotide binding]; other site
323848001914	active site
323848001915	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
323848001916	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
323848001917	MutS domain I; Region: MutS_I; pfam01624
323848001918	MutS domain II; Region: MutS_II; pfam05188
323848001919	MutS family domain IV; Region: MutS_IV; pfam05190
323848001920	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
323848001921	Walker A/P-loop; other site
323848001922	ATP binding site [chemical binding]; other site
323848001923	Q-loop/lid; other site
323848001924	ABC transporter signature motif; other site
323848001925	Walker B; other site
323848001926	D-loop; other site
323848001927	H-loop/switch region; other site
323848001928	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
323848001929	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
323848001930	active site
323848001931	dimerization interface [polypeptide binding]; other site
323848001932	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
323848001933	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
323848001934	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848001935	Rrf2 family protein; Region: rrf2_super; TIGR00738
323848001936	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
323848001937	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
323848001938	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323848001939	catalytic residue [active]
323848001940	VacJ like lipoprotein; Region: VacJ; cl01073
323848001941	Predicted membrane protein [Function unknown]; Region: COG3671
323848001942	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323848001943	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323848001944	ligand binding site [chemical binding]; other site
323848001945	flexible hinge region; other site
323848001946	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
323848001947	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
323848001948	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
323848001949	active site
323848001950	tetramer interface [polypeptide binding]; other site
323848001951	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
323848001952	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
323848001953	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
323848001954	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848001955	Walker A/P-loop; other site
323848001956	ATP binding site [chemical binding]; other site
323848001957	Q-loop/lid; other site
323848001958	ABC transporter signature motif; other site
323848001959	Walker B; other site
323848001960	D-loop; other site
323848001961	H-loop/switch region; other site
323848001962	CbbX; Provisional; Region: cbbX; CHL00181
323848001963	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848001964	Walker A motif; other site
323848001965	ATP binding site [chemical binding]; other site
323848001966	Walker B motif; other site
323848001967	arginine finger; other site
323848001968	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
323848001969	multimerization interface [polypeptide binding]; other site
323848001970	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
323848001971	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
323848001972	homodimer interface [polypeptide binding]; other site
323848001973	active site
323848001974	heterodimer interface [polypeptide binding]; other site
323848001975	catalytic residue [active]
323848001976	metal binding site [ion binding]; metal-binding site
323848001977	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848001978	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
323848001979	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
323848001980	putative dimerization interface [polypeptide binding]; other site
323848001981	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
323848001982	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
323848001983	NodT family; Region: outer_NodT; TIGR01845
323848001984	Outer membrane efflux protein; Region: OEP; pfam02321
323848001985	Outer membrane efflux protein; Region: OEP; pfam02321
323848001986	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
323848001987	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
323848001988	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
323848001989	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323848001990	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
323848001991	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848001992	Rrf2 family protein; Region: rrf2_super; TIGR00738
323848001993	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
323848001994	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
323848001995	putative ABC transporter; Region: ycf24; CHL00085
323848001996	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
323848001997	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
323848001998	Walker A/P-loop; other site
323848001999	ATP binding site [chemical binding]; other site
323848002000	Q-loop/lid; other site
323848002001	ABC transporter signature motif; other site
323848002002	Walker B; other site
323848002003	D-loop; other site
323848002004	H-loop/switch region; other site
323848002005	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
323848002006	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
323848002007	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
323848002008	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
323848002009	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
323848002010	catalytic residue [active]
323848002011	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
323848002012	trimerization site [polypeptide binding]; other site
323848002013	active site
323848002014	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
323848002015	NifU-like domain; Region: NifU; cl00484
323848002016	Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863
323848002017	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
323848002018	active site
323848002019	dimer interface [polypeptide binding]; other site
323848002020	metal binding site [ion binding]; metal-binding site
323848002021	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
323848002022	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
323848002023	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717
323848002024	substrate binding site [chemical binding]; other site
323848002025	active site
323848002026	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
323848002027	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848002028	active site
323848002029	phosphorylation site [posttranslational modification]
323848002030	intermolecular recognition site; other site
323848002031	dimerization interface [polypeptide binding]; other site
323848002032	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
323848002033	DNA binding site [nucleotide binding]
323848002034	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848002035	dimer interface [polypeptide binding]; other site
323848002036	phosphorylation site [posttranslational modification]
323848002037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848002038	ATP binding site [chemical binding]; other site
323848002039	Mg2+ binding site [ion binding]; other site
323848002040	G-X-G motif; other site
323848002041	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
323848002042	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
323848002043	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
323848002044	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
323848002045	high affinity sulphate transporter 1; Region: sulP; TIGR00815
323848002046	Sulfate transporter family; Region: Sulfate_transp; cl00967
323848002047	GTPase RsgA; Reviewed; Region: PRK00098
323848002048	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
323848002049	GTPase/OB domain interface [polypeptide binding]; other site
323848002050	GTPase/Zn-binding domain interface [polypeptide binding]; other site
323848002051	GTP/Mg2+ binding site [chemical binding]; other site
323848002052	G4 box; other site
323848002053	G5 box; other site
323848002054	G1 box; other site
323848002055	Switch I region; other site
323848002056	G2 box; other site
323848002057	G3 box; other site
323848002058	Switch II region; other site
323848002059	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
323848002060	aromatic arch; other site
323848002061	DCoH dimer interaction site [polypeptide binding]; other site
323848002062	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
323848002063	DCoH tetramer interaction site [polypeptide binding]; other site
323848002064	substrate binding site [chemical binding]; other site
323848002065	Peptidase family M48; Region: Peptidase_M48; cl12018
323848002066	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
323848002067	putative active site [active]
323848002068	putative substrate binding site [chemical binding]; other site
323848002069	catalytic site [active]
323848002070	dimer interface [polypeptide binding]; other site
323848002071	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
323848002072	putative homodimer interface [polypeptide binding]; other site
323848002073	putative active site pocket [active]
323848002074	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
323848002075	glycogen synthase; Provisional; Region: glgA; PRK00654
323848002076	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
323848002077	ADP-binding pocket [chemical binding]; other site
323848002078	homodimer interface [polypeptide binding]; other site
323848002079	glycogen branching enzyme; Provisional; Region: PRK05402
323848002080	Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855
323848002081	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
323848002082	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
323848002083	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
323848002084	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
323848002085	ligand binding site [chemical binding]; other site
323848002086	oligomer interface [polypeptide binding]; other site
323848002087	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651
323848002088	dimer interface [polypeptide binding]; other site
323848002089	N-terminal domain interface [polypeptide binding]; other site
323848002090	sulfate 1 binding site; other site
323848002091	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
323848002092	Ferredoxin [Energy production and conversion]; Region: COG1146
323848002093	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
323848002094	probable DNA repair protein; Region: TIGR03623
323848002095	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
323848002096	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
323848002097	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
323848002098	UvrD/REP helicase; Region: UvrD-helicase; cl14126
323848002099	UvrD/REP helicase; Region: UvrD-helicase; cl14126
323848002100	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
323848002101	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222
323848002102	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
323848002103	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
323848002104	Ligand binding site [chemical binding]; other site
323848002105	Putative Catalytic site [active]
323848002106	DXD motif; other site
323848002107	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
323848002108	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
323848002109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
323848002110	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
323848002111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848002112	active site
323848002113	phosphorylation site [posttranslational modification]
323848002114	intermolecular recognition site; other site
323848002115	dimerization interface [polypeptide binding]; other site
323848002116	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
323848002117	DNA binding residues [nucleotide binding]
323848002118	dimerization interface [polypeptide binding]; other site
323848002119	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
323848002120	ABC Carbohydrate and Solute Transporters-like subgroup.  This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols.  ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259
323848002121	Walker A/P-loop; other site
323848002122	ATP binding site [chemical binding]; other site
323848002123	Q-loop/lid; other site
323848002124	ABC transporter signature motif; other site
323848002125	Walker B; other site
323848002126	D-loop; other site
323848002127	H-loop/switch region; other site
323848002128	TOBE domain; Region: TOBE_2; cl01440
323848002129	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
323848002130	dimer interface [polypeptide binding]; other site
323848002131	conserved gate region; other site
323848002132	putative PBP binding loops; other site
323848002133	ABC-ATPase subunit interface; other site
323848002134	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
323848002135	dimer interface [polypeptide binding]; other site
323848002136	conserved gate region; other site
323848002137	putative PBP binding loops; other site
323848002138	ABC-ATPase subunit interface; other site
323848002139	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
323848002140	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
323848002141	Domain of unknown function (DUF74); Region: DUF74; cl00426
323848002142	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
323848002143	NADP binding site [chemical binding]; other site
323848002144	homodimer interface [polypeptide binding]; other site
323848002145	active site
323848002146	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
323848002147	short chain dehydrogenase; Provisional; Region: PRK05693
323848002148	NADP binding site [chemical binding]; other site
323848002149	active site
323848002150	steroid binding site; other site
323848002151	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
323848002152	Domain of unknown function DUF20; Region: UPF0118; cl00465
323848002153	Domain of unknown function (DUF336); Region: DUF336; cl01249
323848002154	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
323848002155	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
323848002156	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204
323848002157	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
323848002158	active site
323848002159	ADP/pyrophosphate binding site [chemical binding]; other site
323848002160	dimerization interface [polypeptide binding]; other site
323848002161	allosteric effector site; other site
323848002162	fructose-1,6-bisphosphate binding site; other site
323848002163	adenylate kinase; Reviewed; Region: adk; PRK00279
323848002164	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
323848002165	AMP-binding site [chemical binding]; other site
323848002166	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
323848002167	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
323848002168	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
323848002169	HIGH motif; other site
323848002170	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
323848002171	active site
323848002172	KMSKS motif; other site
323848002173	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
323848002174	tRNA binding surface [nucleotide binding]; other site
323848002175	anticodon binding site; other site
323848002176	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
323848002177	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
323848002178	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848002179	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848002180	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848002181	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
323848002182	multifunctional aminopeptidase A; Provisional; Region: PRK00913
323848002183	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433
323848002184	interface (dimer of trimers) [polypeptide binding]; other site
323848002185	Substrate-binding/catalytic site; other site
323848002186	Zn-binding sites [ion binding]; other site
323848002187	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
323848002188	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
323848002189	DNA binding site [nucleotide binding]
323848002190	active site
323848002191	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
323848002192	N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798
323848002193	Int/Topo IB signature motif; other site
323848002194	active site
323848002195	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323848002196	ligand binding site [chemical binding]; other site
323848002197	Protein of unknown function (DUF454); Region: DUF454; cl01063
323848002198	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
323848002199	elongation factor Tu; Reviewed; Region: PRK00049
323848002200	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
323848002201	G1 box; other site
323848002202	GEF interaction site [polypeptide binding]; other site
323848002203	GTP/Mg2+ binding site [chemical binding]; other site
323848002204	Switch I region; other site
323848002205	G2 box; other site
323848002206	G3 box; other site
323848002207	Switch II region; other site
323848002208	G4 box; other site
323848002209	G5 box; other site
323848002210	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
323848002211	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
323848002212	Antibiotic Binding Site [chemical binding]; other site
323848002213	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
323848002214	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
323848002215	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
323848002216	putative homodimer interface [polypeptide binding]; other site
323848002217	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
323848002218	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
323848002219	23S rRNA interface [nucleotide binding]; other site
323848002220	L7/L12 interface [polypeptide binding]; other site
323848002221	putative thiostrepton binding site; other site
323848002222	L25 interface [polypeptide binding]; other site
323848002223	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403
323848002224	mRNA/rRNA interface [nucleotide binding]; other site
323848002225	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797
323848002226	23S rRNA interface [nucleotide binding]; other site
323848002227	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
323848002228	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
323848002229	peripheral dimer interface [polypeptide binding]; other site
323848002230	core dimer interface [polypeptide binding]; other site
323848002231	L10 interface [polypeptide binding]; other site
323848002232	L11 interface [polypeptide binding]; other site
323848002233	putative EF-Tu interaction site [polypeptide binding]; other site
323848002234	putative EF-G interaction site [polypeptide binding]; other site
323848002235	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
323848002236	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591
323848002237	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
323848002238	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591
323848002239	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
323848002240	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
323848002241	RPB11 interaction site [polypeptide binding]; other site
323848002242	RPB12 interaction site [polypeptide binding]; other site
323848002243	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
323848002244	RPB3 interaction site [polypeptide binding]; other site
323848002245	RPB1 interaction site [polypeptide binding]; other site
323848002246	RPB11 interaction site [polypeptide binding]; other site
323848002247	RPB10 interaction site [polypeptide binding]; other site
323848002248	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
323848002249	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
323848002250	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
323848002251	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
323848002252	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
323848002253	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
323848002254	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
323848002255	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
323848002256	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
323848002257	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
323848002258	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
323848002259	DNA binding site [nucleotide binding]
323848002260	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
323848002261	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
323848002262	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
323848002263	inhibitor-cofactor binding pocket; inhibition site
323848002264	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848002265	catalytic residue [active]
323848002266	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
323848002267	S17 interaction site [polypeptide binding]; other site
323848002268	S8 interaction site; other site
323848002269	16S rRNA interaction site [nucleotide binding]; other site
323848002270	streptomycin interaction site [chemical binding]; other site
323848002271	23S rRNA interaction site [nucleotide binding]; other site
323848002272	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
323848002273	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
323848002274	elongation factor G; Reviewed; Region: PRK00007
323848002275	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
323848002276	G1 box; other site
323848002277	putative GEF interaction site [polypeptide binding]; other site
323848002278	GTP/Mg2+ binding site [chemical binding]; other site
323848002279	Switch I region; other site
323848002280	G2 box; other site
323848002281	G3 box; other site
323848002282	Switch II region; other site
323848002283	G4 box; other site
323848002284	G5 box; other site
323848002285	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
323848002286	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
323848002287	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
323848002288	elongation factor Tu; Reviewed; Region: PRK00049
323848002289	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
323848002290	G1 box; other site
323848002291	GEF interaction site [polypeptide binding]; other site
323848002292	GTP/Mg2+ binding site [chemical binding]; other site
323848002293	Switch I region; other site
323848002294	G2 box; other site
323848002295	G3 box; other site
323848002296	Switch II region; other site
323848002297	G4 box; other site
323848002298	G5 box; other site
323848002299	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
323848002300	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
323848002301	Antibiotic Binding Site [chemical binding]; other site
323848002302	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
323848002303	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
323848002304	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
323848002305	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
323848002306	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
323848002307	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
323848002308	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
323848002309	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
323848002310	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
323848002311	putative translocon binding site; other site
323848002312	protein-rRNA interface [nucleotide binding]; other site
323848002313	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
323848002314	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The...; Region: 30S_S3_KH; cd02412
323848002315	G-X-X-G motif; other site
323848002316	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
323848002317	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
323848002318	23S rRNA interface [nucleotide binding]; other site
323848002319	5S rRNA interface [nucleotide binding]; other site
323848002320	putative antibiotic binding site [chemical binding]; other site
323848002321	L25 interface [polypeptide binding]; other site
323848002322	L27 interface [polypeptide binding]; other site
323848002323	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cl09943
323848002324	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
323848002325	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
323848002326	KOW motif; Region: KOW; cl00354
323848002327	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
323848002328	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
323848002329	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
323848002330	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
323848002331	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
323848002332	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
323848002333	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
323848002334	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
323848002335	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
323848002336	5S rRNA interface [nucleotide binding]; other site
323848002337	23S rRNA interface [nucleotide binding]; other site
323848002338	L5 interface [polypeptide binding]; other site
323848002339	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
323848002340	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
323848002341	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
323848002342	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658
323848002343	23S rRNA binding site [nucleotide binding]; other site
323848002344	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
323848002345	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
323848002346	SecY translocase; Region: SecY; pfam00344
323848002347	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
323848002348	rRNA binding site [nucleotide binding]; other site
323848002349	predicted 30S ribosome binding site; other site
323848002350	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
323848002351	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
323848002352	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
323848002353	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
323848002354	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
323848002355	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
323848002356	RNA binding surface [nucleotide binding]; other site
323848002357	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
323848002358	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
323848002359	alphaNTD homodimer interface [polypeptide binding]; other site
323848002360	alphaNTD - beta interaction site [polypeptide binding]; other site
323848002361	alphaNTD - beta' interaction site [polypeptide binding]; other site
323848002362	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
323848002363	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
323848002364	Protein of unknown function (DUF2806); Region: DUF2806; cl12560
323848002365	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
323848002366	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848002367	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323848002368	active site
323848002369	HIGH motif; other site
323848002370	nucleotide binding site [chemical binding]; other site
323848002371	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323848002372	KMSKS motif; other site
323848002373	Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; cl04829
323848002374	Ammonia monooxygenase; Region: AMO; cl03602
323848002375	Monooxygenase subunit B protein; Region: Monooxygenase_B; cl04718
323848002376	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
323848002377	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
323848002378	DNA-binding site [nucleotide binding]; DNA binding site
323848002379	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323848002380	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848002381	homodimer interface [polypeptide binding]; other site
323848002382	catalytic residue [active]
323848002383	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485
323848002384	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
323848002385	Uncharacterized conserved protein [Function unknown]; Region: COG0327
323848002386	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309
323848002387	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
323848002388	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
323848002389	protein binding site [polypeptide binding]; other site
323848002390	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
323848002391	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
323848002392	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
323848002393	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
323848002394	nucleotide binding site/active site [active]
323848002395	HIT family signature motif; other site
323848002396	catalytic residue [active]
323848002397	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
323848002398	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
323848002399	Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107
323848002400	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731
323848002401	substrate binding site [chemical binding]; other site
323848002402	glutamase interaction surface [polypeptide binding]; other site
323848002403	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
323848002404	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732
323848002405	catalytic residues [active]
323848002406	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
323848002407	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
323848002408	putative active site [active]
323848002409	oxyanion strand; other site
323848002410	catalytic triad [active]
323848002411	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
323848002412	putative active site pocket [active]
323848002413	4-fold oligomerization interface [polypeptide binding]; other site
323848002414	metal binding residues [ion binding]; metal-binding site
323848002415	3-fold/trimer interface [polypeptide binding]; other site
323848002416	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
323848002417	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323848002418	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848002419	homodimer interface [polypeptide binding]; other site
323848002420	catalytic residue [active]
323848002421	E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572
323848002422	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
323848002423	NAD binding site [chemical binding]; other site
323848002424	dimerization interface [polypeptide binding]; other site
323848002425	product binding site; other site
323848002426	substrate binding site [chemical binding]; other site
323848002427	zinc binding site [ion binding]; other site
323848002428	catalytic residues [active]
323848002429	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
323848002430	Response regulator receiver domain; Region: Response_reg; pfam00072
323848002431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848002432	active site
323848002433	phosphorylation site [posttranslational modification]
323848002434	intermolecular recognition site; other site
323848002435	dimerization interface [polypeptide binding]; other site
323848002436	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848002437	phosphorylation site [posttranslational modification]
323848002438	intermolecular recognition site; other site
323848002439	PAS domain S-box; Region: sensory_box; TIGR00229
323848002440	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848002441	putative active site [active]
323848002442	heme pocket [chemical binding]; other site
323848002443	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848002444	metal binding site [ion binding]; metal-binding site
323848002445	active site
323848002446	I-site; other site
323848002447	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848002448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848002449	active site
323848002450	phosphorylation site [posttranslational modification]
323848002451	intermolecular recognition site; other site
323848002452	dimerization interface [polypeptide binding]; other site
323848002453	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323848002454	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848002455	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323848002456	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323848002457	ligand binding site [chemical binding]; other site
323848002458	flexible hinge region; other site
323848002459	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848002460	putative switch regulator; other site
323848002461	non-specific DNA interactions [nucleotide binding]; other site
323848002462	DNA binding site [nucleotide binding]
323848002463	sequence specific DNA binding site [nucleotide binding]; other site
323848002464	putative cAMP binding site [chemical binding]; other site
323848002465	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848002466	dimer interface [polypeptide binding]; other site
323848002467	phosphorylation site [posttranslational modification]
323848002468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848002469	ATP binding site [chemical binding]; other site
323848002470	Mg2+ binding site [ion binding]; other site
323848002471	G-X-G motif; other site
323848002472	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
323848002473	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848002474	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848002475	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848002476	Haemolysin-III related; Region: HlyIII; cl03831
323848002477	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
323848002478	DNA-binding site [nucleotide binding]; DNA binding site
323848002479	RNA-binding motif; other site
323848002480	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
323848002481	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
323848002482	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
323848002483	active site
323848002484	catalytic residues [active]
323848002485	Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097
323848002486	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
323848002487	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
323848002488	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323848002489	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
323848002490	NodT family; Region: outer_NodT; TIGR01845
323848002491	Outer membrane efflux protein; Region: OEP; pfam02321
323848002492	Outer membrane efflux protein; Region: OEP; pfam02321
323848002493	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
323848002494	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
323848002495	metal binding site [ion binding]; metal-binding site
323848002496	putative dimer interface [polypeptide binding]; other site
323848002497	Predicted membrane protein [Function unknown]; Region: COG2860
323848002498	UPF0126 domain; Region: UPF0126; pfam03458
323848002499	UPF0126 domain; Region: UPF0126; pfam03458
323848002500	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
323848002501	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848002502	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848002503	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
323848002504	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
323848002505	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
323848002506	E3 interaction surface; other site
323848002507	lipoyl attachment site [posttranslational modification]; other site
323848002508	e3 binding domain; Region: E3_binding; pfam02817
323848002509	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
323848002510	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
323848002511	TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016
323848002512	TPP-binding site [chemical binding]; other site
323848002513	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
323848002514	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
323848002515	dimer interface [polypeptide binding]; other site
323848002516	Citrate synthase; Region: Citrate_synt; pfam00285
323848002517	active site
323848002518	citrylCoA binding site [chemical binding]; other site
323848002519	NADH binding [chemical binding]; other site
323848002520	cationic pore residues; other site
323848002521	oxalacetate/citrate binding site [chemical binding]; other site
323848002522	coenzyme A binding site [chemical binding]; other site
323848002523	catalytic triad [active]
323848002524	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
323848002525	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
323848002526	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
323848002527	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848002528	domain; Region: Succ_DH_flav_C; pfam02910
323848002529	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
323848002530	SdhC subunit interface [polypeptide binding]; other site
323848002531	proximal heme binding site [chemical binding]; other site
323848002532	cardiolipin binding site; other site
323848002533	Iron-sulfur protein interface; other site
323848002534	proximal quinone binding site [chemical binding]; other site
323848002535	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
323848002536	Iron-sulfur protein interface; other site
323848002537	proximal quinone binding site [chemical binding]; other site
323848002538	SdhD (CybS) interface [polypeptide binding]; other site
323848002539	proximal heme binding site [chemical binding]; other site
323848002540	malate dehydrogenase; Provisional; Region: PRK05442
323848002541	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
323848002542	NAD(P) binding site [chemical binding]; other site
323848002543	dimer interface [polypeptide binding]; other site
323848002544	malate binding site [chemical binding]; other site
323848002545	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
323848002546	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
323848002547	tetramer interface [polypeptide binding]; other site
323848002548	active site
323848002549	Mg2+/Mn2+ binding site [ion binding]; other site
323848002550	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
323848002551	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416
323848002552	oxalacetate binding site [chemical binding]; other site
323848002553	citrylCoA binding site [chemical binding]; other site
323848002554	coenzyme A binding site [chemical binding]; other site
323848002555	catalytic triad [active]
323848002556	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195
323848002557	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
323848002558	2-methylcitrate dehydratase; Region: prpD; TIGR02330
323848002559	TM0106 family; Region: TIGR03491
323848002560	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
323848002561	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
323848002562	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
323848002563	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848002564	NAD(P) binding site [chemical binding]; other site
323848002565	active site
323848002566	aconitate hydratase 1; Region: aconitase_1; TIGR01341
323848002567	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
323848002568	substrate binding site [chemical binding]; other site
323848002569	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
323848002570	ligand binding site [chemical binding]; other site
323848002571	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
323848002572	substrate binding site [chemical binding]; other site
323848002573	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323848002574	pantoate--beta-alanine ligase; Region: panC; TIGR00018
323848002575	Pantoate-beta-alanine ligase; Region: PanC; cd00560
323848002576	active site
323848002577	ATP-binding site [chemical binding]; other site
323848002578	pantoate-binding site; other site
323848002579	HXXH motif; other site
323848002580	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
323848002581	active site
323848002582	oligomerization interface [polypeptide binding]; other site
323848002583	metal binding site [ion binding]; metal-binding site
323848002584	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
323848002585	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673
323848002586	Substrate-binding site [chemical binding]; other site
323848002587	Substrate specificity [chemical binding]; other site
323848002588	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
323848002589	catalytic center binding site [active]
323848002590	ATP binding site [chemical binding]; other site
323848002591	poly(A) polymerase; Region: pcnB; TIGR01942
323848002592	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
323848002593	active site
323848002594	NTP binding site [chemical binding]; other site
323848002595	metal binding triad [ion binding]; metal-binding site
323848002596	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
323848002597	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
323848002598	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
323848002599	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
323848002600	Walker A/P-loop; other site
323848002601	ATP binding site [chemical binding]; other site
323848002602	Q-loop/lid; other site
323848002603	ABC transporter signature motif; other site
323848002604	Walker B; other site
323848002605	D-loop; other site
323848002606	H-loop/switch region; other site
323848002607	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
323848002608	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488
323848002609	generic binding surface II; other site
323848002610	ssDNA binding site; other site
323848002611	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323848002612	ATP binding site [chemical binding]; other site
323848002613	putative Mg++ binding site [ion binding]; other site
323848002614	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323848002615	nucleotide binding region [chemical binding]; other site
323848002616	ATP-binding site [chemical binding]; other site
323848002617	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
323848002618	homotrimer interaction site [polypeptide binding]; other site
323848002619	putative active site [active]
323848002620	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369
323848002621	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
323848002622	hinge; other site
323848002623	active site
323848002624	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
323848002625	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
323848002626	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
323848002627	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848002628	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
323848002629	ABC transporter; Region: ABC_tran_2; pfam12848
323848002630	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
323848002631	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
323848002632	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048
323848002633	C-terminal domain interface [polypeptide binding]; other site
323848002634	GSH binding site (G-site) [chemical binding]; other site
323848002635	dimer interface [polypeptide binding]; other site
323848002636	GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178
323848002637	dimer interface [polypeptide binding]; other site
323848002638	N-terminal domain interface [polypeptide binding]; other site
323848002639	putative substrate binding pocket (H-site) [chemical binding]; other site
323848002640	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
323848002641	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
323848002642	putative metal binding site [ion binding]; other site
323848002643	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
323848002644	HSP70 interaction site [polypeptide binding]; other site
323848002645	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
323848002646	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
323848002647	FtsX-like permease family; Region: FtsX; pfam02687
323848002648	FtsX-like permease family; Region: FtsX; pfam02687
323848002649	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
323848002650	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
323848002651	Walker A/P-loop; other site
323848002652	ATP binding site [chemical binding]; other site
323848002653	Q-loop/lid; other site
323848002654	ABC transporter signature motif; other site
323848002655	Walker B; other site
323848002656	D-loop; other site
323848002657	H-loop/switch region; other site
323848002658	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
323848002659	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
323848002660	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
323848002661	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
323848002662	hypothetical protein; Provisional; Region: PRK08609
323848002663	active site
323848002664	primer binding site [nucleotide binding]; other site
323848002665	NTP  binding site [chemical binding]; other site
323848002666	metal binding triad [ion binding]; metal-binding site
323848002667	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
323848002668	Archease protein family (DUF101/UPF0211); Region: Archease; cl00606
323848002669	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032
323848002670	hypothetical protein; Reviewed; Region: PRK09588
323848002671	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323848002672	Ligand Binding Site [chemical binding]; other site
323848002673	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552
323848002674	30S subunit binding site; other site
323848002675	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
323848002676	DNA-binding site [nucleotide binding]; DNA binding site
323848002677	RNA-binding motif; other site
323848002678	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
323848002679	Isochorismatase family; Region: Isochorismatase; pfam00857
323848002680	catalytic triad [active]
323848002681	metal binding site [ion binding]; metal-binding site
323848002682	conserved cis-peptide bond; other site
323848002683	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
323848002684	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570
323848002685	active site
323848002686	N-formylglutamate amidohydrolase; Region: FGase; cl01522
323848002687	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
323848002688	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296
323848002689	putative active site [active]
323848002690	SEC-C motif; Region: SEC-C; cl12132
323848002691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848002692	binding surface
323848002693	TPR motif; other site
323848002694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848002695	binding surface
323848002696	TPR motif; other site
323848002697	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848002698	binding surface
323848002699	TPR motif; other site
323848002700	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848002701	binding surface
323848002702	TPR motif; other site
323848002703	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848002704	S-adenosylmethionine binding site [chemical binding]; other site
323848002705	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
323848002706	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
323848002707	ATP-binding site [chemical binding]; other site
323848002708	Gluconate-6-phosphate binding site [chemical binding]; other site
323848002709	Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608
323848002710	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
323848002711	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
323848002712	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
323848002713	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
323848002714	conserved cys residue [active]
323848002715	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
323848002716	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
323848002717	RES domain; Region: RES; cl02411
323848002718	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
323848002719	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
323848002720	integrase; Provisional; Region: PRK09692
323848002721	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
323848002722	active site
323848002723	Int/Topo IB signature motif; other site
323848002724	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323848002725	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898
323848002726	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
323848002727	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323848002728	nucleotide binding region [chemical binding]; other site
323848002729	ATP-binding site [chemical binding]; other site
323848002730	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
323848002731	active site
323848002732	putative substrate binding region [chemical binding]; other site
323848002733	HlyD family secretion protein; Region: HlyD_2; pfam12700
323848002734	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323848002735	CARDB; Region: CARDB; pfam07705
323848002736	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
323848002737	active site
323848002738	Uncharacterized conserved protein [Function unknown]; Region: COG5276
323848002739	SdiA-regulated; Region: SdiA-regulated; cl06158
323848002740	putative active site [active]
323848002741	SdiA-regulated; Region: SdiA-regulated; cl06158
323848002742	putative active site [active]
323848002743	PEP-CTERM motif; Region: VPEP; pfam07589
323848002744	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
323848002745	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication...; Region: TOPRIM_primases; cd01029
323848002746	active site
323848002747	metal binding site [ion binding]; metal-binding site
323848002748	interdomain interaction site; other site
323848002749	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
323848002750	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
323848002751	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
323848002752	putative active site [active]
323848002753	putative NTP binding site [chemical binding]; other site
323848002754	putative nucleic acid binding site [nucleotide binding]; other site
323848002755	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
323848002756	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
323848002757	C-term; Region: GreA_GreB; pfam01272
323848002758	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
323848002759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848002760	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
323848002761	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
323848002762	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
323848002763	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
323848002764	urea carboxylase; Region: urea_carbox; TIGR02712
323848002765	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323848002766	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848002767	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
323848002768	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
323848002769	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
323848002770	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
323848002771	carboxyltransferase (CT) interaction site; other site
323848002772	biotinylation site [posttranslational modification]; other site
323848002773	allophanate hydrolase; Provisional; Region: PRK08186
323848002774	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
323848002775	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
323848002776	GST_C family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its...; Region: GST_C_Metaxin; cd03193
323848002777	putative N-terminal domain interface [polypeptide binding]; other site
323848002778	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848002779	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
323848002780	FtsX-like permease family; Region: FtsX; pfam02687
323848002781	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
323848002782	active site
323848002783	DNA polymerase IV; Validated; Region: PRK02406
323848002784	DNA binding site [nucleotide binding]
323848002785	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323848002786	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
323848002787	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
323848002788	Walker A/P-loop; other site
323848002789	ATP binding site [chemical binding]; other site
323848002790	Q-loop/lid; other site
323848002791	ABC transporter signature motif; other site
323848002792	Walker B; other site
323848002793	D-loop; other site
323848002794	H-loop/switch region; other site
323848002795	Staphylococcal nuclease homologues; Region: SNc; smart00318
323848002796	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
323848002797	Catalytic site; other site
323848002798	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
323848002799	FtsX-like permease family; Region: FtsX; pfam02687
323848002800	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
323848002801	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
323848002802	FtsX-like permease family; Region: FtsX; pfam02687
323848002803	BT1 family; Region: BT1; pfam03092
323848002804	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
323848002805	substrate binding pocket [chemical binding]; other site
323848002806	substrate-Mg2+ binding site; other site
323848002807	aspartate-rich region 1; other site
323848002808	aspartate-rich region 2; other site
323848002809	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
323848002810	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
323848002811	PEP-CTERM motif; Region: VPEP; pfam07589
323848002812	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
323848002813	ADP-ribose binding site [chemical binding]; other site
323848002814	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
323848002815	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747
323848002816	active site
323848002817	Cytochrome c; Region: Cytochrom_C; cl11414
323848002818	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
323848002819	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
323848002820	active site
323848002821	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323848002822	putative substrate translocation pore; other site
323848002823	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
323848002824	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
323848002825	active site
323848002826	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
323848002827	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848002828	CoA-transferase family III; Region: CoA_transf_3; cl00778
323848002829	CoA-transferase family III; Region: CoA_transf_3; cl00778
323848002830	Ubiquitin-like proteins; Region: UBQ; cl00155
323848002831	charged pocket; other site
323848002832	hydrophobic patch; other site
323848002833	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
323848002834	MPN+ (JAMM) motif; other site
323848002835	Zinc-binding site [ion binding]; other site
323848002836	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
323848002837	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757
323848002838	ATP binding site [chemical binding]; other site
323848002839	substrate interface [chemical binding]; other site
323848002840	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
323848002841	active site residue [active]
323848002842	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
323848002843	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
323848002844	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
323848002845	Transglycosylase; Region: Transgly; cl07896
323848002846	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
323848002847	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
323848002848	Protein of unkown function (DUF1881); Region: DUF1881; pfam08964
323848002849	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
323848002850	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980
323848002851	dimer interface [polypeptide binding]; other site
323848002852	[2Fe-2S] cluster binding site [ion binding]; other site
323848002853	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
323848002854	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
323848002855	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
323848002856	dimer interface [polypeptide binding]; other site
323848002857	conserved gate region; other site
323848002858	putative PBP binding loops; other site
323848002859	ABC-ATPase subunit interface; other site
323848002860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
323848002861	dimer interface [polypeptide binding]; other site
323848002862	conserved gate region; other site
323848002863	ABC-ATPase subunit interface; other site
323848002864	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
323848002865	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848002866	Walker A/P-loop; other site
323848002867	ATP binding site [chemical binding]; other site
323848002868	Q-loop/lid; other site
323848002869	ABC transporter signature motif; other site
323848002870	Walker B; other site
323848002871	D-loop; other site
323848002872	H-loop/switch region; other site
323848002873	TOBE domain; Region: TOBE_2; cl01440
323848002874	RelB antitoxin; Region: RelB; cl01171
323848002875	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
323848002876	putative active site [active]
323848002877	SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877
323848002878	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
323848002879	Presynaptic Site I dimer interface [polypeptide binding]; other site
323848002880	catalytic residues [active]
323848002881	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
323848002882	Synaptic Flat tetramer interface [polypeptide binding]; other site
323848002883	Synaptic Site I dimer interface [polypeptide binding]; other site
323848002884	DNA binding site [nucleotide binding]
323848002885	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848002886	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848002887	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848002888	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848002889	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848002890	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
323848002891	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
323848002892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
323848002893	SCP-2 sterol transfer family; Region: SCP2; cl01225
323848002894	Tim44-like domain; Region: Tim44; cl09208
323848002895	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323848002896	Ligand Binding Site [chemical binding]; other site
323848002897	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323848002898	Ligand Binding Site [chemical binding]; other site
323848002899	Acetokinase family; Region: Acetate_kinase; cl01029
323848002900	putative phosphoketolase; Provisional; Region: PRK05261
323848002901	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
323848002902	TPP-binding site; other site
323848002903	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
323848002904	XFP C-terminal domain; Region: XFP_C; pfam09363
323848002905	Cupin domain; Region: Cupin_2; cl09118
323848002906	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
323848002907	Domain of unknown function (DUF299); Region: DUF299; cl00780
323848002908	phosphoenolpyruvate synthase; Validated; Region: PRK06464
323848002909	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
323848002910	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
323848002911	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
323848002912	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848002913	dimer interface [polypeptide binding]; other site
323848002914	phosphorylation site [posttranslational modification]
323848002915	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848002916	ATP binding site [chemical binding]; other site
323848002917	Mg2+ binding site [ion binding]; other site
323848002918	G-X-G motif; other site
323848002919	Stringent starvation protein B; Region: SspB; cl01120
323848002920	stringent starvation protein A; Provisional; Region: sspA; PRK09481
323848002921	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
323848002922	C-terminal domain interface [polypeptide binding]; other site
323848002923	putative GSH binding site (G-site) [chemical binding]; other site
323848002924	dimer interface [polypeptide binding]; other site
323848002925	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_C_SspA; cd03186
323848002926	dimer interface [polypeptide binding]; other site
323848002927	N-terminal domain interface [polypeptide binding]; other site
323848002928	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
323848002929	cytochrome b; Provisional; Region: CYTB; MTH00145
323848002930	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284
323848002931	Qi binding site; other site
323848002932	intrachain domain interface; other site
323848002933	interchain domain interface [polypeptide binding]; other site
323848002934	heme bH binding site [chemical binding]; other site
323848002935	heme bL binding site [chemical binding]; other site
323848002936	Qo binding site; other site
323848002937	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cl00193
323848002938	interchain domain interface [polypeptide binding]; other site
323848002939	intrachain domain interface; other site
323848002940	Qi binding site; other site
323848002941	Qo binding site; other site
323848002942	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
323848002943	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
323848002944	[2Fe-2S] cluster binding site [ion binding]; other site
323848002945	Domain of unknown function (DUF329); Region: DUF329; cl01144
323848002946	hypothetical protein; Provisional; Region: PRK08999
323848002947	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
323848002948	active site
323848002949	8-oxo-dGMP binding site [chemical binding]; other site
323848002950	nudix motif; other site
323848002951	metal binding site [ion binding]; metal-binding site
323848002952	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564
323848002953	thiamine phosphate binding site [chemical binding]; other site
323848002954	active site
323848002955	pyrophosphate binding site [ion binding]; other site
323848002956	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
323848002957	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848002958	Walker A motif; other site
323848002959	ATP binding site [chemical binding]; other site
323848002960	Walker B motif; other site
323848002961	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051
323848002962	Ca2+ binding site [ion binding]; other site
323848002963	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152
323848002964	heterotetramer interface [polypeptide binding]; other site
323848002965	active site pocket [active]
323848002966	cleavage site
323848002967	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291
323848002968	CPxP  motif; other site
323848002969	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
323848002970	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419
323848002971	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
323848002972	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539
323848002973	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417
323848002974	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
323848002975	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064
323848002976	putative dimer interface [polypeptide binding]; other site
323848002977	[2Fe-2S] cluster binding site [ion binding]; other site
323848002978	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
323848002979	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
323848002980	SLBB domain; Region: SLBB; pfam10531
323848002981	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
323848002982	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
323848002983	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
323848002984	catalytic loop [active]
323848002985	iron binding site [ion binding]; other site
323848002986	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
323848002987	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
323848002988	[4Fe-4S] binding site [ion binding]; other site
323848002989	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929
323848002990	molybdopterin cofactor binding site; other site
323848002991	NADH dehydrogenase; Region: NADHdh; cl00469
323848002992	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
323848002993	4Fe-4S binding domain; Region: Fer4; cl02805
323848002994	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
323848002995	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
323848002996	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
323848002997	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
323848002998	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
323848002999	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
323848003000	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
323848003001	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
323848003002	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
323848003003	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
323848003004	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
323848003005	Trm112p-like protein; Region: Trm112p; cl01066
323848003006	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
323848003007	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
323848003008	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323848003009	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
323848003010	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489
323848003011	generic binding surface II; other site
323848003012	generic binding surface I; other site
323848003013	Protein of unknown function (DUF423); Region: DUF423; cl01008
323848003014	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
323848003015	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848003016	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
323848003017	Peptidase family M48; Region: Peptidase_M48; cl12018
323848003018	VacJ like lipoprotein; Region: VacJ; cl01073
323848003019	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
323848003020	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
323848003021	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
323848003022	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
323848003023	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
323848003024	dimer interface [polypeptide binding]; other site
323848003025	active site residues [active]
323848003026	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
323848003027	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
323848003028	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and...; Region: Orn_deC_like; cd00615
323848003029	homodimer interface [polypeptide binding]; other site
323848003030	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848003031	catalytic residue [active]
323848003032	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
323848003033	acetylornithine aminotransferase; Provisional; Region: PRK02627
323848003034	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
323848003035	inhibitor-cofactor binding pocket; inhibition site
323848003036	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848003037	catalytic residue [active]
323848003038	ornithine carbamoyltransferase; Provisional; Region: PRK00779
323848003039	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
323848003040	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
323848003041	argininosuccinate synthase; Provisional; Region: PLN00200
323848003042	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
323848003043	ANP binding site [chemical binding]; other site
323848003044	Substrate Binding Site II [chemical binding]; other site
323848003045	Substrate Binding Site I [chemical binding]; other site
323848003046	Protein of unknown function (DUF520); Region: DUF520; cl00723
323848003047	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
323848003048	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
323848003049	catalytic triad [active]
323848003050	FecR protein; Region: FecR; pfam04773
323848003051	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
323848003052	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323848003053	Gram-negative bacterial tonB protein; Region: TonB; cl10048
323848003054	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
323848003055	RNA polymerase factor sigma-70; Validated; Region: PRK09047
323848003056	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
323848003057	DNA binding residues [nucleotide binding]
323848003058	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
323848003059	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
323848003060	RDD family; Region: RDD; cl00746
323848003061	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
323848003062	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
323848003063	Predicted amidohydrolase [General function prediction only]; Region: COG0388
323848003064	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
323848003065	putative active site [active]
323848003066	catalytic triad [active]
323848003067	dimer interface [polypeptide binding]; other site
323848003068	TIGR02099 family protein; Region: TIGR02099
323848003069	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
323848003070	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
323848003071	metal binding triad; other site
323848003072	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
323848003073	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
323848003074	metal binding triad; other site
323848003075	branched-chain amino acid aminotransferase; Provisional; Region: PRK12479
323848003076	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557
323848003077	homodimer interface [polypeptide binding]; other site
323848003078	substrate-cofactor binding pocket; other site
323848003079	catalytic residue [active]
323848003080	Zinc-finger domain; Region: zf-CHCC; cl01821
323848003081	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
323848003082	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
323848003083	active site
323848003084	substrate binding site [chemical binding]; other site
323848003085	metal binding site [ion binding]; metal-binding site
323848003086	Low molecular weight phosphatase family; Region: LMWPc; cd00115
323848003087	Active site [active]
323848003088	ribonuclease E; Reviewed; Region: rne; PRK10811
323848003089	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
323848003090	homodimer interface [polypeptide binding]; other site
323848003091	oligonucleotide binding site [chemical binding]; other site
323848003092	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
323848003093	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
323848003094	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
323848003095	active site
323848003096	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
323848003097	tandem repeat interface [polypeptide binding]; other site
323848003098	oligomer interface [polypeptide binding]; other site
323848003099	active site residues [active]
323848003100	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
323848003101	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
323848003102	active site
323848003103	dimer interface [polypeptide binding]; other site
323848003104	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
323848003105	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
323848003106	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
323848003107	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
323848003108	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
323848003109	dimer interface [polypeptide binding]; other site
323848003110	active site
323848003111	CoA binding pocket [chemical binding]; other site
323848003112	Acyl transferase domain; Region: Acyl_transf_1; cl08282
323848003113	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
323848003114	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
323848003115	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
323848003116	NAD(P) binding site [chemical binding]; other site
323848003117	homotetramer interface [polypeptide binding]; other site
323848003118	homodimer interface [polypeptide binding]; other site
323848003119	active site
323848003120	Phosphopantetheine attachment site; Region: PP-binding; cl09936
323848003121	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
323848003122	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
323848003123	dimer interface [polypeptide binding]; other site
323848003124	active site
323848003125	YceG-like family; Region: YceG; pfam02618
323848003126	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
323848003127	dimerization interface [polypeptide binding]; other site
323848003128	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
323848003129	malate--CoA ligase subunit beta; Provisional; Region: PRK14046
323848003130	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848003131	CoA-ligase; Region: Ligase_CoA; pfam00549
323848003132	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
323848003133	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848003134	CoA-ligase; Region: Ligase_CoA; pfam00549
323848003135	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
323848003136	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
323848003137	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485
323848003138	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
323848003139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
323848003140	dimer interface [polypeptide binding]; other site
323848003141	conserved gate region; other site
323848003142	putative PBP binding loops; other site
323848003143	ABC-ATPase subunit interface; other site
323848003144	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
323848003145	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14252
323848003146	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
323848003147	Walker A/P-loop; other site
323848003148	ATP binding site [chemical binding]; other site
323848003149	Q-loop/lid; other site
323848003150	ABC transporter signature motif; other site
323848003151	Walker B; other site
323848003152	D-loop; other site
323848003153	H-loop/switch region; other site
323848003154	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
323848003155	substrate binding site [chemical binding]; other site
323848003156	dimer interface [polypeptide binding]; other site
323848003157	catalytic triad [active]
323848003158	Preprotein translocase SecG subunit; Region: SecG; cl09123
323848003159	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
323848003160	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419
323848003161	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539
323848003162	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417
323848003163	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
323848003164	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064
323848003165	putative dimer interface [polypeptide binding]; other site
323848003166	[2Fe-2S] cluster binding site [ion binding]; other site
323848003167	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
323848003168	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
323848003169	SLBB domain; Region: SLBB; pfam10531
323848003170	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
323848003171	NADH dehydrogenase subunit G; Validated; Region: PRK09129
323848003172	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
323848003173	catalytic loop [active]
323848003174	iron binding site [ion binding]; other site
323848003175	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
323848003176	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions...; Region: MopB_NDH-1_NuoG2; cd02772
323848003177	NADH dehydrogenase; Region: NADHdh; cl00469
323848003178	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
323848003179	4Fe-4S binding domain; Region: Fer4; cl02805
323848003180	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
323848003181	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
323848003182	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
323848003183	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
323848003184	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
323848003185	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
323848003186	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
323848003187	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
323848003188	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
323848003189	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
323848003190	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
323848003191	transmembrane helices; other site
323848003192	SEC-C motif; Region: SEC-C; cl12132
323848003193	hypothetical protein; Provisional; Region: PRK04233
323848003194	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
323848003195	Phosphotransferase enzyme family; Region: APH; pfam01636
323848003196	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
323848003197	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
323848003198	heat shock protein 90; Provisional; Region: PRK05218
323848003199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848003200	ATP binding site [chemical binding]; other site
323848003201	Mg2+ binding site [ion binding]; other site
323848003202	G-X-G motif; other site
323848003203	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
323848003204	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848003205	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
323848003206	putative dimerization interface [polypeptide binding]; other site
323848003207	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
323848003208	Outer membrane efflux protein; Region: OEP; pfam02321
323848003209	Outer membrane efflux protein; Region: OEP; pfam02321
323848003210	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323848003211	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
323848003212	Nitrogen regulatory protein P-II; Region: P-II; cl00412
323848003213	Nitrogen regulatory protein P-II; Region: P-II; cl00412
323848003214	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250
323848003215	feedback inhibition sensing region; other site
323848003216	homohexameric interface [polypeptide binding]; other site
323848003217	nucleotide binding site [chemical binding]; other site
323848003218	N-acetyl-L-glutamate binding site [chemical binding]; other site
323848003219	division inhibitor protein; Provisional; Region: slmA; PRK09480
323848003220	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323848003221	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
323848003222	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757
323848003223	ATP binding site [chemical binding]; other site
323848003224	substrate interface [chemical binding]; other site
323848003225	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
323848003226	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
323848003227	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
323848003228	protein binding site [polypeptide binding]; other site
323848003229	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
323848003230	Catalytic dyad [active]
323848003231	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
323848003232	Peptidase family M23; Region: Peptidase_M23; pfam01551
323848003233	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
323848003234	catalytic core [active]
323848003235	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
323848003236	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
323848003237	active site residue [active]
323848003238	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
323848003239	GSH binding site [chemical binding]; other site
323848003240	catalytic residues [active]
323848003241	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
323848003242	SecA binding site; other site
323848003243	Preprotein binding site; other site
323848003244	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
323848003245	Bacterial SH3 domain; Region: SH3_3; cl02551
323848003246	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
323848003247	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848003248	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
323848003249	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
323848003250	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
323848003251	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
323848003252	biotin synthetase; Region: bioB; TIGR00433
323848003253	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
323848003254	FeS/SAM binding site; other site
323848003255	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
323848003256	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
323848003257	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454
323848003258	substrate-cofactor binding pocket; other site
323848003259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848003260	catalytic residue [active]
323848003261	putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738
323848003262	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
323848003263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848003264	S-adenosylmethionine binding site [chemical binding]; other site
323848003265	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
323848003266	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
323848003267	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
323848003268	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
323848003269	potential catalytic triad [active]
323848003270	conserved cys residue [active]
323848003271	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
323848003272	DNA-binding site [nucleotide binding]; DNA binding site
323848003273	RNA-binding motif; other site
323848003274	Membrane protein of unknown function; Region: DUF360; cl00850
323848003275	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848003276	active site
323848003277	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
323848003278	phosphorylation site [posttranslational modification]
323848003279	intermolecular recognition site; other site
323848003280	dimerization interface [polypeptide binding]; other site
323848003281	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
323848003282	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
323848003283	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848003284	metal binding site [ion binding]; metal-binding site
323848003285	active site
323848003286	I-site; other site
323848003287	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848003288	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
323848003289	Cupin superfamily protein; Region: Cupin_4; pfam08007
323848003290	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
323848003291	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848003292	ATP binding site [chemical binding]; other site
323848003293	Mg2+ binding site [ion binding]; other site
323848003294	G-X-G motif; other site
323848003295	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
323848003296	ATP binding site [chemical binding]; other site
323848003297	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
323848003298	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
323848003299	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848003300	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
323848003301	substrate binding site [chemical binding]; other site
323848003302	dimerization interface [polypeptide binding]; other site
323848003303	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
323848003304	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
323848003305	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
323848003306	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
323848003307	Active Sites [active]
323848003308	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
323848003309	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
323848003310	Active Sites [active]
323848003311	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
323848003312	CysN_ATPS subfamily.  CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes.  ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate.  CysD, which...; Region: CysN_ATPS; cd04166
323848003313	CysD dimerization site [polypeptide binding]; other site
323848003314	G1 box; other site
323848003315	putative GEF interaction site [polypeptide binding]; other site
323848003316	GTP/Mg2+ binding site [chemical binding]; other site
323848003317	Switch I region; other site
323848003318	G2 box; other site
323848003319	G3 box; other site
323848003320	Switch II region; other site
323848003321	G4 box; other site
323848003322	G5 box; other site
323848003323	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695
323848003324	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095
323848003325	putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567
323848003326	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-...; Region: DHOD_e_trans_like; cd06192
323848003327	FAD binding pocket [chemical binding]; other site
323848003328	FAD binding motif [chemical binding]; other site
323848003329	phosphate binding motif [ion binding]; other site
323848003330	beta-alpha-beta structure motif; other site
323848003331	NAD binding pocket [chemical binding]; other site
323848003332	Iron coordination center [ion binding]; other site
323848003333	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
323848003334	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222
323848003335	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
323848003336	NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566
323848003337	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
323848003338	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
323848003339	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222
323848003340	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
323848003341	NAD(P) binding site [chemical binding]; other site
323848003342	putative cation:proton antiport protein; Provisional; Region: PRK10669
323848003343	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
323848003344	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848003345	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
323848003346	catalytic residues [active]
323848003347	CHASE3 domain; Region: CHASE3; cl05000
323848003348	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848003349	dimer interface [polypeptide binding]; other site
323848003350	phosphorylation site [posttranslational modification]
323848003351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848003352	ATP binding site [chemical binding]; other site
323848003353	Mg2+ binding site [ion binding]; other site
323848003354	G-X-G motif; other site
323848003355	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
323848003356	response regulator GlrR; Provisional; Region: PRK15115
323848003357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848003358	active site
323848003359	phosphorylation site [posttranslational modification]
323848003360	intermolecular recognition site; other site
323848003361	dimerization interface [polypeptide binding]; other site
323848003362	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848003363	Walker A motif; other site
323848003364	ATP binding site [chemical binding]; other site
323848003365	Walker B motif; other site
323848003366	arginine finger; other site
323848003367	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
323848003368	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
323848003369	Erythromycin esterase homolog [General function prediction only]; Region: COG2312
323848003370	Erythromycin esterase; Region: Erythro_esteras; pfam05139
323848003371	Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097
323848003372	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323848003373	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464
323848003374	putative dimer interface [polypeptide binding]; other site
323848003375	FOG: CBS domain [General function prediction only]; Region: COG0517
323848003376	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622
323848003377	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464
323848003378	putative dimer interface [polypeptide binding]; other site
323848003379	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
323848003380	substrate binding site [chemical binding]; other site
323848003381	Rhamnan synthesis protein F; Region: RgpF; cl01529
323848003382	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848003383	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
323848003384	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848003385	Walker A/P-loop; other site
323848003386	ATP binding site [chemical binding]; other site
323848003387	Q-loop/lid; other site
323848003388	ABC transporter signature motif; other site
323848003389	Walker B; other site
323848003390	D-loop; other site
323848003391	H-loop/switch region; other site
323848003392	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
323848003393	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
323848003394	putative DNA binding site [nucleotide binding]; other site
323848003395	putative homodimer interface [polypeptide binding]; other site
323848003396	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
323848003397	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
323848003398	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
323848003399	active site
323848003400	DNA binding site [nucleotide binding]
323848003401	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
323848003402	DNA binding site [nucleotide binding]
323848003403	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: PaeLigD_Pol_like; cd04862
323848003404	nucleotide binding site [chemical binding]; other site
323848003405	O-methyltransferase; Region: Methyltransf_2; pfam00891
323848003406	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
323848003407	putative hydrophobic ligand binding site [chemical binding]; other site
323848003408	short chain dehydrogenase; Provisional; Region: PRK06701
323848003409	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
323848003410	NAD binding site [chemical binding]; other site
323848003411	metal binding site [ion binding]; metal-binding site
323848003412	active site
323848003413	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
323848003414	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323848003415	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
323848003416	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848003417	Uncharacterized protein conserved in bacteria (DUF2329); Region: DUF2329; pfam10091
323848003418	Putative carbohydrate binding domain; Region: CBM_X; pfam06204
323848003419	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
323848003420	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
323848003421	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
323848003422	Putative carbohydrate binding domain; Region: CBM_X; pfam06204
323848003423	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
323848003424	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
323848003425	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323848003426	ligand binding site [chemical binding]; other site
323848003427	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
323848003428	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
323848003429	active site
323848003430	catalytic triad [active]
323848003431	oxyanion hole [active]
323848003432	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
323848003433	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
323848003434	conserved cys residue [active]
323848003435	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323848003436	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848003437	dimer interface [polypeptide binding]; other site
323848003438	phosphorylation site [posttranslational modification]
323848003439	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848003440	ATP binding site [chemical binding]; other site
323848003441	Mg2+ binding site [ion binding]; other site
323848003442	G-X-G motif; other site
323848003443	Response regulator receiver domain; Region: Response_reg; pfam00072
323848003444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848003445	active site
323848003446	phosphorylation site [posttranslational modification]
323848003447	intermolecular recognition site; other site
323848003448	dimerization interface [polypeptide binding]; other site
323848003449	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
323848003450	substrate binding pocket [chemical binding]; other site
323848003451	membrane-bound complex binding site; other site
323848003452	hinge residues; other site
323848003453	periplasmic protein; Provisional; Region: PRK10568
323848003454	BON domain; Region: BON; cl02771
323848003455	BON domain; Region: BON; cl02771
323848003456	CsbD-like; Region: CsbD; cl01272
323848003457	periplasmic protein; Provisional; Region: PRK10568
323848003458	BON domain; Region: BON; cl02771
323848003459	BON domain; Region: BON; cl02771
323848003460	CsbD-like; Region: CsbD; cl01272
323848003461	FOG: CBS domain [General function prediction only]; Region: COG0517
323848003462	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622
323848003463	GMP synthase; Reviewed; Region: guaA; PRK00074
323848003464	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
323848003465	AMP/PPi binding site [chemical binding]; other site
323848003466	candidate oxyanion hole; other site
323848003467	catalytic triad [active]
323848003468	potential glutamine specificity residues [chemical binding]; other site
323848003469	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
323848003470	ATP Binding subdomain [chemical binding]; other site
323848003471	Ligand Binding sites [chemical binding]; other site
323848003472	Dimerization subdomain; other site
323848003473	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
323848003474	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
323848003475	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
323848003476	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381
323848003477	active site
323848003478	Uncharacterised protein family (UPF0125); Region: UPF0125; cl01096
323848003479	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
323848003480	putative coenzyme Q binding site [chemical binding]; other site
323848003481	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
323848003482	SmpB-tmRNA interface; other site
323848003483	cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127
323848003484	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
323848003485	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
323848003486	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
323848003487	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848003488	binding surface
323848003489	TPR motif; other site
323848003490	Cytochrome C biogenesis protein; Region: CcmH; cl01179
323848003491	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
323848003492	catalytic residues [active]
323848003493	central insert; other site
323848003494	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
323848003495	CcmE; Region: CcmE; cl00994
323848003496	Heme exporter protein D (CcmD); Region: CcmD; cl11475
323848003497	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
323848003498	AlkA N-terminal domain; Region: AlkA_N; pfam06029
323848003499	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
323848003500	minor groove reading motif; other site
323848003501	helix-hairpin-helix signature motif; other site
323848003502	substrate binding pocket [chemical binding]; other site
323848003503	active site
323848003504	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
323848003505	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323848003506	Coenzyme A binding pocket [chemical binding]; other site
323848003507	CcmB protein; Region: CcmB; cl01016
323848003508	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848003509	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
323848003510	Walker A/P-loop; other site
323848003511	ATP binding site [chemical binding]; other site
323848003512	Q-loop/lid; other site
323848003513	ABC transporter signature motif; other site
323848003514	Walker B; other site
323848003515	D-loop; other site
323848003516	H-loop/switch region; other site
323848003517	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
323848003518	putative dimer interface [polypeptide binding]; other site
323848003519	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
323848003520	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
323848003521	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
323848003522	metal ion-dependent adhesion site (MIDAS); other site
323848003523	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
323848003524	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
323848003525	nucleoside/Zn binding site; other site
323848003526	dimer interface [polypeptide binding]; other site
323848003527	catalytic motif [active]
323848003528	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
323848003529	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323848003530	CTP synthetase; Validated; Region: pyrG; PRK05380
323848003531	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113
323848003532	Catalytic site [active]
323848003533	Active site [active]
323848003534	UTP binding site [chemical binding]; other site
323848003535	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
323848003536	active site
323848003537	putative oxyanion hole; other site
323848003538	catalytic triad [active]
323848003539	enolase; Provisional; Region: eno; PRK00077
323848003540	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
323848003541	dimer interface [polypeptide binding]; other site
323848003542	metal binding site [ion binding]; metal-binding site
323848003543	substrate binding pocket [chemical binding]; other site
323848003544	Septum formation initiator; Region: DivIC; cl11433
323848003545	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
323848003546	ABC-ATPase subunit  interface; other site
323848003547	dimer interface [polypeptide binding]; other site
323848003548	putative PBP binding regions; other site
323848003549	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
323848003550	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
323848003551	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
323848003552	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
323848003553	intersubunit interface [polypeptide binding]; other site
323848003554	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
323848003555	nickel responsive regulator; Provisional; Region: PRK02967
323848003556	Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448
323848003557	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
323848003558	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
323848003559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848003560	active site
323848003561	phosphorylation site [posttranslational modification]
323848003562	intermolecular recognition site; other site
323848003563	dimerization interface [polypeptide binding]; other site
323848003564	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
323848003565	DNA binding residues [nucleotide binding]
323848003566	dimerization interface [polypeptide binding]; other site
323848003567	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
323848003568	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323848003569	Histidine kinase; Region: HisKA_3; pfam07730
323848003570	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848003571	ATP binding site [chemical binding]; other site
323848003572	Mg2+ binding site [ion binding]; other site
323848003573	G-X-G motif; other site
323848003574	UreD urease accessory protein; Region: UreD; cl00530
323848003575	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
323848003576	alpha-gamma subunit interface [polypeptide binding]; other site
323848003577	beta-gamma subunit interface [polypeptide binding]; other site
323848003578	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407
323848003579	gamma-beta subunit interface [polypeptide binding]; other site
323848003580	alpha-beta subunit interface [polypeptide binding]; other site
323848003581	urease subunit alpha; Reviewed; Region: ureC; PRK13207
323848003582	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
323848003583	subunit interactions [polypeptide binding]; other site
323848003584	active site
323848003585	flap region; other site
323848003586	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cd00571
323848003587	dimer interface [polypeptide binding]; other site
323848003588	catalytic residues [active]
323848003589	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
323848003590	UreF; Region: UreF; pfam01730
323848003591	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
323848003592	Urea transporter; Region: UT; cl01829
323848003593	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
323848003594	DNA binding site [nucleotide binding]
323848003595	Predicted ATPase [General function prediction only]; Region: COG3899
323848003596	Integrase core domain; Region: rve; cl01316
323848003597	PEP-CTERM motif; Region: VPEP; pfam07589
323848003598	trehalose synthase; Region: treS_nterm; TIGR02456
323848003599	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
323848003600	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
323848003601	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
323848003602	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
323848003603	metal ion-dependent adhesion site (MIDAS); other site
323848003604	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848003605	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
323848003606	Walker A motif; other site
323848003607	ATP binding site [chemical binding]; other site
323848003608	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
323848003609	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275
323848003610	Putative water exit pathway; other site
323848003611	Binuclear center (active site) [active]
323848003612	K-pathway; other site
323848003613	Putative proton exit pathway; other site
323848003614	Cytochrome c; Region: Cytochrom_C; cl11414
323848003615	Cytochrome c; Region: Cytochrom_C; cl11414
323848003616	Secretin and TonB N terminus short domain; Region: STN; pfam07660
323848003617	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
323848003618	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323848003619	N-terminal plug; other site
323848003620	ligand-binding site [chemical binding]; other site
323848003621	Protein of unknown function (DUF466); Region: DUF466; cl01082
323848003622	Carbon starvation protein CstA; Region: CstA; cl00856
323848003623	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
323848003624	active site
323848003625	DNA binding site [nucleotide binding]
323848003626	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
323848003627	translation elongation factor P; Region: efp; TIGR00038
323848003628	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
323848003629	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470
323848003630	RNA binding site [nucleotide binding]; other site
323848003631	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794
323848003632	RNA binding site [nucleotide binding]; other site
323848003633	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
323848003634	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
323848003635	active site 1 [active]
323848003636	dimer interface [polypeptide binding]; other site
323848003637	hexamer interface [polypeptide binding]; other site
323848003638	active site 2 [active]
323848003639	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
323848003640	GIY-YIG catalytic domain; Region: GIY-YIG; cl01061
323848003641	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
323848003642	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
323848003643	Protein of unknown function (DUF2591); Region: DUF2591; cl11584
323848003644	Response regulator receiver domain; Region: Response_reg; pfam00072
323848003645	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944
323848003646	active site
323848003647	phosphorylation site [posttranslational modification]
323848003648	intermolecular recognition site; other site
323848003649	dimerization interface [polypeptide binding]; other site
323848003650	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
323848003651	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
323848003652	This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain.  They export...; Region: ABCC_Protease_Secretion; cd03246
323848003653	Walker A/P-loop; other site
323848003654	ATP binding site [chemical binding]; other site
323848003655	Q-loop/lid; other site
323848003656	ABC transporter signature motif; other site
323848003657	Walker B; other site
323848003658	D-loop; other site
323848003659	H-loop/switch region; other site
323848003660	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
323848003661	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
323848003662	Outer membrane efflux protein; Region: OEP; pfam02321
323848003663	Outer membrane efflux protein; Region: OEP; pfam02321
323848003664	Protein of unknown function DUF72; Region: DUF72; cl00777
323848003665	Cupin domain; Region: Cupin_2; cl09118
323848003666	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
323848003667	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323848003668	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848003669	active site
323848003670	phosphorylation site [posttranslational modification]
323848003671	intermolecular recognition site; other site
323848003672	dimerization interface [polypeptide binding]; other site
323848003673	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848003674	PAS fold; Region: PAS_3; pfam08447
323848003675	putative active site [active]
323848003676	heme pocket [chemical binding]; other site
323848003677	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323848003678	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848003679	dimer interface [polypeptide binding]; other site
323848003680	phosphorylation site [posttranslational modification]
323848003681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848003682	ATP binding site [chemical binding]; other site
323848003683	Mg2+ binding site [ion binding]; other site
323848003684	G-X-G motif; other site
323848003685	Response regulator receiver domain; Region: Response_reg; pfam00072
323848003686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848003687	active site
323848003688	phosphorylation site [posttranslational modification]
323848003689	intermolecular recognition site; other site
323848003690	dimerization interface [polypeptide binding]; other site
323848003691	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
323848003692	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
323848003693	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
323848003694	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
323848003695	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848003696	putative active site [active]
323848003697	heme pocket [chemical binding]; other site
323848003698	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848003699	dimer interface [polypeptide binding]; other site
323848003700	phosphorylation site [posttranslational modification]
323848003701	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848003702	ATP binding site [chemical binding]; other site
323848003703	Mg2+ binding site [ion binding]; other site
323848003704	G-X-G motif; other site
323848003705	CHRD domain; Region: CHRD; cl06473
323848003706	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
323848003707	DNA-binding site [nucleotide binding]; DNA binding site
323848003708	RNA-binding motif; other site
323848003709	oxidoreductase; Provisional; Region: PRK06128
323848003710	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848003711	NAD(P) binding site [chemical binding]; other site
323848003712	active site
323848003713	putative transposase OrfB; Reviewed; Region: PHA02517
323848003714	Integrase core domain; Region: rve; cl01316
323848003715	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848003716	IS2 transposase TnpB; Reviewed; Region: PRK09409
323848003717	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848003718	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848003719	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848003720	putative transposase OrfB; Reviewed; Region: PHA02517
323848003721	Integrase core domain; Region: rve; cl01316
323848003722	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
323848003723	Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012
323848003724	Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036
323848003725	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
323848003726	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323848003727	flagellar motor protein MotB; Validated; Region: motB; PRK09041
323848003728	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323848003729	ligand binding site [chemical binding]; other site
323848003730	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
323848003731	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
323848003732	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
323848003733	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
323848003734	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
323848003735	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
323848003736	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
323848003737	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
323848003738	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
323848003739	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323848003740	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
323848003741	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
323848003742	DNA binding residues [nucleotide binding]
323848003743	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323848003744	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
323848003745	flagellar motor protein MotD; Reviewed; Region: PRK09038
323848003746	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323848003747	ligand binding site [chemical binding]; other site
323848003748	FlgN protein; Region: FlgN; cl09176
323848003749	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
323848003750	SAF domain; Region: SAF; cl00555
323848003751	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848003752	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848003753	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
323848003754	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
323848003755	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
323848003756	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
323848003757	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
323848003758	Flagellar hook capping protein; Region: FlgD; cl04347
323848003759	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
323848003760	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
323848003761	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
323848003762	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
323848003763	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
323848003764	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
323848003765	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
323848003766	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
323848003767	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
323848003768	Flagellar L-ring protein; Region: FlgH; cl00905
323848003769	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
323848003770	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
323848003771	Rod binding protein; Region: Rod-binding; cl01626
323848003772	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
323848003773	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
323848003774	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
323848003775	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
323848003776	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192
323848003777	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
323848003778	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
323848003779	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
323848003780	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848003781	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
323848003782	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
323848003783	catalytic residues [active]
323848003784	hypothetical protein; Provisional; Region: PRK13560
323848003785	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
323848003786	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
323848003787	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
323848003788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848003789	active site
323848003790	phosphorylation site [posttranslational modification]
323848003791	intermolecular recognition site; other site
323848003792	dimerization interface [polypeptide binding]; other site
323848003793	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
323848003794	DNA binding residues [nucleotide binding]
323848003795	dimerization interface [polypeptide binding]; other site
323848003796	flagellin; Reviewed; Region: PRK08869
323848003797	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
323848003798	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
323848003799	FlaG protein; Region: FlaG; cl00591
323848003800	flagellar capping protein; Validated; Region: fliD; PRK08724
323848003801	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
323848003802	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
323848003803	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
323848003804	Flagellar protein FliS; Region: FliS; cl00654
323848003805	Flagellar protein FliT; Region: FliT; cl05125
323848003806	Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669
323848003807	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
323848003808	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
323848003809	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
323848003810	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
323848003811	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
323848003812	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
323848003813	FliG C-terminal domain; Region: FliG_C; pfam01706
323848003814	flagellar assembly protein H; Validated; Region: fliH; PRK05687
323848003815	Flagellar assembly protein FliH; Region: FliH; pfam02108
323848003816	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
323848003817	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
323848003818	Walker A motif/ATP binding site; other site
323848003819	Walker B motif; other site
323848003820	Flagellar FliJ protein; Region: FliJ; cl09161
323848003821	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
323848003822	Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669
323848003823	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
323848003824	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
323848003825	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
323848003826	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
323848003827	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
323848003828	FliP family; Region: FliP; cl00593
323848003829	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
323848003830	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
323848003831	aspartate aminotransferase; Provisional; Region: PRK08361
323848003832	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323848003833	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848003834	homodimer interface [polypeptide binding]; other site
323848003835	catalytic residue [active]
323848003836	excinuclease ABC subunit B; Provisional; Region: PRK05298
323848003837	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323848003838	ATP binding site [chemical binding]; other site
323848003839	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323848003840	nucleotide binding region [chemical binding]; other site
323848003841	ATP-binding site [chemical binding]; other site
323848003842	Ultra-violet resistance protein B; Region: UvrB; pfam12344
323848003843	UvrB/uvrC motif; Region: UVR; pfam02151
323848003844	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
323848003845	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323848003846	catalytic residue [active]
323848003847	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323848003848	active site
323848003849	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
323848003850	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
323848003851	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
323848003852	potential catalytic triad [active]
323848003853	conserved cys residue [active]
323848003854	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
323848003855	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
323848003856	NAD(P) binding site [chemical binding]; other site
323848003857	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
323848003858	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
323848003859	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
323848003860	Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255
323848003861	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
323848003862	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
323848003863	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
323848003864	dimer interface [polypeptide binding]; other site
323848003865	MgtC family; Region: MgtC; cl12207
323848003866	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
323848003867	short chain dehydrogenase; Provisional; Region: PRK12937
323848003868	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
323848003869	NADP binding site [chemical binding]; other site
323848003870	homodimer interface [polypeptide binding]; other site
323848003871	active site
323848003872	substrate binding site [chemical binding]; other site
323848003873	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
323848003874	dimer interface [polypeptide binding]; other site
323848003875	putative metal binding site [ion binding]; other site
323848003876	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
323848003877	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
323848003878	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
323848003879	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
323848003880	putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
323848003881	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
323848003882	active site
323848003883	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
323848003884	DNA binding site [nucleotide binding]
323848003885	dimer interface [polypeptide binding]; other site
323848003886	Phage integrase family; Region: Phage_integrase; pfam00589
323848003887	Int/Topo IB signature motif; other site
323848003888	active site
323848003889	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
323848003890	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
323848003891	DNA polymerase III subunit delta'; Validated; Region: PRK06964
323848003892	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848003893	thymidylate kinase; Validated; Region: tmk; PRK00698
323848003894	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672
323848003895	TMP-binding site; other site
323848003896	ATP-binding site [chemical binding]; other site
323848003897	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
323848003898	TIGR03118 family protein; Region: PEPCTERM_chp_1
323848003899	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
323848003900	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323848003901	ATP binding site [chemical binding]; other site
323848003902	putative Mg++ binding site [ion binding]; other site
323848003903	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
323848003904	Helicase associated domain (HA2); Region: HA2; cl04503
323848003905	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
323848003906	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
323848003907	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
323848003908	active site
323848003909	phosphate binding residues; other site
323848003910	catalytic residues [active]
323848003911	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
323848003912	maltose O-acetyltransferase; Provisional; Region: PRK10092
323848003913	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
323848003914	active site
323848003915	substrate binding site [chemical binding]; other site
323848003916	trimer interface [polypeptide binding]; other site
323848003917	CoA binding site [chemical binding]; other site
323848003918	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848003919	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
323848003920	active site
323848003921	nucleophile elbow; other site
323848003922	patatin-related protein; Region: TIGR03607
323848003923	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
323848003924	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
323848003925	putative NAD(P) binding site [chemical binding]; other site
323848003926	putative substrate binding site [chemical binding]; other site
323848003927	catalytic Zn binding site [ion binding]; other site
323848003928	structural Zn binding site [ion binding]; other site
323848003929	dimer interface [polypeptide binding]; other site
323848003930	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
323848003931	Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856
323848003932	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
323848003933	putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase; Provisional; Region: PRK14507
323848003934	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
323848003935	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
323848003936	Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853
323848003937	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
323848003938	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
323848003939	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
323848003940	trehalose synthase; Region: treS_nterm; TIGR02456
323848003941	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
323848003942	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286
323848003943	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
323848003944	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
323848003945	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
323848003946	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
323848003947	Outer membrane efflux protein; Region: OEP; pfam02321
323848003948	Outer membrane efflux protein; Region: OEP; pfam02321
323848003949	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
323848003950	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
323848003951	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
323848003952	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250
323848003953	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
323848003954	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848003955	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848003956	ABC-2 type transporter; Region: ABC2_membrane; cl11417
323848003957	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
323848003958	ABC-2 type transporter; Region: ABC2_membrane; cl11417
323848003959	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
323848003960	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848003961	Walker A/P-loop; other site
323848003962	ATP binding site [chemical binding]; other site
323848003963	Q-loop/lid; other site
323848003964	ABC transporter signature motif; other site
323848003965	Walker B; other site
323848003966	D-loop; other site
323848003967	H-loop/switch region; other site
323848003968	PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
323848003969	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848003970	Walker A/P-loop; other site
323848003971	ATP binding site [chemical binding]; other site
323848003972	Q-loop/lid; other site
323848003973	ABC transporter signature motif; other site
323848003974	Walker B; other site
323848003975	D-loop; other site
323848003976	H-loop/switch region; other site
323848003977	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
323848003978	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
323848003979	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
323848003980	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
323848003981	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323848003982	N-terminal plug; other site
323848003983	ligand-binding site [chemical binding]; other site
323848003984	Integrase core domain; Region: rve; cl01316
323848003985	O-Antigen ligase; Region: Wzy_C; cl04850
323848003986	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
323848003987	Probable Catalytic site [active]
323848003988	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848003989	putative transposase OrfB; Reviewed; Region: PHA02517
323848003990	Integrase core domain; Region: rve; cl01316
323848003991	Integrase core domain; Region: rve; cl01316
323848003992	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
323848003993	putative transposase OrfB; Reviewed; Region: PHA02517
323848003994	Integrase core domain; Region: rve; cl01316
323848003995	putative transposase OrfB; Reviewed; Region: PHA02517
323848003996	Integrase core domain; Region: rve; cl01316
323848003997	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848003998	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222
323848003999	catalytic residue [active]
323848004000	Phage terminase large subunit; Region: Terminase_3; cl12054
323848004001	Terminase-like family; Region: Terminase_6; pfam03237
323848004002	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
323848004003	putative active site [active]
323848004004	thiamine pyrophosphate protein; Provisional; Region: PRK08273
323848004005	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
323848004006	PYR/PP interface [polypeptide binding]; other site
323848004007	tetramer interface [polypeptide binding]; other site
323848004008	dimer interface [polypeptide binding]; other site
323848004009	TPP binding site [chemical binding]; other site
323848004010	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
323848004011	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014
323848004012	TPP-binding site [chemical binding]; other site
323848004013	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
323848004014	Pirin-related protein [General function prediction only]; Region: COG1741
323848004015	Cupin domain; Region: Cupin_2; cl09118
323848004016	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
323848004017	LysR family transcriptional regulator; Provisional; Region: PRK14997
323848004018	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848004019	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
323848004020	putative effector binding pocket; other site
323848004021	putative dimerization interface [polypeptide binding]; other site
323848004022	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
323848004023	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
323848004024	catalytic Zn binding site [ion binding]; other site
323848004025	NAD binding site [chemical binding]; other site
323848004026	structural Zn binding site [ion binding]; other site
323848004027	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
323848004028	FAD binding domain; Region: FAD_binding_4; pfam01565
323848004029	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
323848004030	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
323848004031	Autotransporter beta-domain; Region: Autotransporter; cl02365
323848004032	Predicted outer membrane protein [Function unknown]; Region: COG3652
323848004033	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
323848004034	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848004035	putative transposase OrfB; Reviewed; Region: PHA02517
323848004036	Integrase core domain; Region: rve; cl01316
323848004037	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
323848004038	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
323848004039	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
323848004040	Walker A/P-loop; other site
323848004041	ATP binding site [chemical binding]; other site
323848004042	Q-loop/lid; other site
323848004043	ABC transporter signature motif; other site
323848004044	Walker B; other site
323848004045	D-loop; other site
323848004046	H-loop/switch region; other site
323848004047	short chain dehydrogenase; Provisional; Region: PRK06181
323848004048	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
323848004049	putative NAD(P) binding site [chemical binding]; other site
323848004050	active site
323848004051	PAS domain S-box; Region: sensory_box; TIGR00229
323848004052	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
323848004053	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
323848004054	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848004055	putative active site [active]
323848004056	heme pocket [chemical binding]; other site
323848004057	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848004058	dimer interface [polypeptide binding]; other site
323848004059	phosphorylation site [posttranslational modification]
323848004060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848004061	ATP binding site [chemical binding]; other site
323848004062	Mg2+ binding site [ion binding]; other site
323848004063	G-X-G motif; other site
323848004064	Response regulator receiver domain; Region: Response_reg; pfam00072
323848004065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848004066	active site
323848004067	phosphorylation site [posttranslational modification]
323848004068	intermolecular recognition site; other site
323848004069	dimerization interface [polypeptide binding]; other site
323848004070	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
323848004071	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848004072	putative active site [active]
323848004073	heme pocket [chemical binding]; other site
323848004074	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848004075	dimer interface [polypeptide binding]; other site
323848004076	phosphorylation site [posttranslational modification]
323848004077	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848004078	ATP binding site [chemical binding]; other site
323848004079	Mg2+ binding site [ion binding]; other site
323848004080	G-X-G motif; other site
323848004081	Response regulator receiver domain; Region: Response_reg; pfam00072
323848004082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848004083	active site
323848004084	phosphorylation site [posttranslational modification]
323848004085	intermolecular recognition site; other site
323848004086	dimerization interface [polypeptide binding]; other site
323848004087	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848004088	PAS fold; Region: PAS_3; pfam08447
323848004089	putative active site [active]
323848004090	heme pocket [chemical binding]; other site
323848004091	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848004092	dimer interface [polypeptide binding]; other site
323848004093	phosphorylation site [posttranslational modification]
323848004094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848004095	ATP binding site [chemical binding]; other site
323848004096	Mg2+ binding site [ion binding]; other site
323848004097	G-X-G motif; other site
323848004098	Response regulator receiver domain; Region: Response_reg; pfam00072
323848004099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848004100	active site
323848004101	phosphorylation site [posttranslational modification]
323848004102	intermolecular recognition site; other site
323848004103	dimerization interface [polypeptide binding]; other site
323848004104	C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311
323848004105	substrate binding site [chemical binding]; other site
323848004106	zinc-binding site [ion binding]; other site
323848004107	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
323848004108	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
323848004109	Fatty acid desaturase; Region: FA_desaturase; pfam00487
323848004110	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
323848004111	putative di-iron ligands [ion binding]; other site
323848004112	Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553
323848004113	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
323848004114	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
323848004115	homodimer interface [polypeptide binding]; other site
323848004116	substrate-cofactor binding pocket; other site
323848004117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848004118	catalytic residue [active]
323848004119	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
323848004120	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
323848004121	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
323848004122	[2Fe-2S] cluster binding site [ion binding]; other site
323848004123	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848004124	metal binding site [ion binding]; metal-binding site
323848004125	active site
323848004126	I-site; other site
323848004127	NodT family; Region: outer_NodT; TIGR01845
323848004128	Outer membrane efflux protein; Region: OEP; pfam02321
323848004129	Outer membrane efflux protein; Region: OEP; pfam02321
323848004130	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
323848004131	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
323848004132	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
323848004133	Walker A/P-loop; other site
323848004134	ATP binding site [chemical binding]; other site
323848004135	Q-loop/lid; other site
323848004136	ABC transporter signature motif; other site
323848004137	Walker B; other site
323848004138	D-loop; other site
323848004139	H-loop/switch region; other site
323848004140	DevC protein; Region: devC; TIGR01185
323848004141	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
323848004142	Pyruvate kinase, alpha/beta domain; Region: PK_C; cl12063
323848004143	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
323848004144	domain interfaces; other site
323848004145	active site
323848004146	MgtC family; Region: MgtC; cl12207
323848004147	Domain of unknown function DUF20; Region: UPF0118; cl00465
323848004148	Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428
323848004149	Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696
323848004150	TIGR03440 family protein; Region: unchr_TIGR03440
323848004151	DinB superfamily; Region: DinB_2; cl00986
323848004152	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
323848004153	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959
323848004154	putative mechanosensitive channel protein; Provisional; Region: PRK11465
323848004155	Mechanosensitive ion channel; Region: MS_channel; pfam00924
323848004156	hydroperoxidase II; Provisional; Region: katE; PRK11249
323848004157	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
323848004158	tetramer interface [polypeptide binding]; other site
323848004159	heme binding pocket [chemical binding]; other site
323848004160	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
323848004161	domain interactions; other site
323848004162	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
323848004163	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848004164	Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277
323848004165	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
323848004166	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
323848004167	HSP70 interaction site [polypeptide binding]; other site
323848004168	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
323848004169	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
323848004170	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
323848004171	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
323848004172	putative active site [active]
323848004173	catalytic site [active]
323848004174	phospholipase D alpha; Region: PLN02270
323848004175	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
323848004176	putative active site [active]
323848004177	catalytic site [active]
323848004178	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
323848004179	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
323848004180	putative catalytic site [active]
323848004181	putative metal binding site [ion binding]; other site
323848004182	putative phosphate binding site [ion binding]; other site
323848004183	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848004184	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848004185	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
323848004186	putative hydrophobic ligand binding site [chemical binding]; other site
323848004187	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
323848004188	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
323848004189	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323848004190	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
323848004191	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
323848004192	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323848004193	non-specific DNA binding site [nucleotide binding]; other site
323848004194	salt bridge; other site
323848004195	sequence-specific DNA binding site [nucleotide binding]; other site
323848004196	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
323848004197	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
323848004198	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
323848004199	OsmC-like protein; Region: OsmC; cl00767
323848004200	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
323848004201	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
323848004202	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
323848004203	dihydrodipicolinate synthase; Region: dapA; TIGR00674
323848004204	dimer interface [polypeptide binding]; other site
323848004205	active site
323848004206	catalytic residue [active]
323848004207	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
323848004208	Clp amino terminal domain; Region: Clp_N; pfam02861
323848004209	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848004210	Walker A motif; other site
323848004211	ATP binding site [chemical binding]; other site
323848004212	Walker B motif; other site
323848004213	arginine finger; other site
323848004214	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848004215	Walker A motif; other site
323848004216	ATP binding site [chemical binding]; other site
323848004217	Walker B motif; other site
323848004218	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
323848004219	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
323848004220	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808
323848004221	active site
323848004222	FMN binding site [chemical binding]; other site
323848004223	substrate binding site [chemical binding]; other site
323848004224	3Fe-4S cluster binding site [ion binding]; other site
323848004225	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
323848004226	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572
323848004227	dimerization interface [polypeptide binding]; other site
323848004228	active site
323848004229	Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792
323848004230	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
323848004231	Proline dehydrogenase; Region: Pro_dh; cl03282
323848004232	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
323848004233	Glutamate binding site [chemical binding]; other site
323848004234	NAD binding site [chemical binding]; other site
323848004235	catalytic residues [active]
323848004236	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
323848004237	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
323848004238	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
323848004239	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
323848004240	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
323848004241	catalytic triad [active]
323848004242	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
323848004243	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560
323848004244	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848004245	catalytic residue [active]
323848004246	homoserine dehydrogenase; Provisional; Region: PRK06349
323848004247	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848004248	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
323848004249	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
323848004250	tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264
323848004251	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323848004252	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848004253	homodimer interface [polypeptide binding]; other site
323848004254	catalytic residue [active]
323848004255	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome...; Region: Xcc1710_like; cd05560
323848004256	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
323848004257	Response regulator receiver domain; Region: Response_reg; pfam00072
323848004258	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848004259	active site
323848004260	phosphorylation site [posttranslational modification]
323848004261	intermolecular recognition site; other site
323848004262	dimerization interface [polypeptide binding]; other site
323848004263	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848004264	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
323848004265	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
323848004266	dimerization interface [polypeptide binding]; other site
323848004267	PAS domain S-box; Region: sensory_box; TIGR00229
323848004268	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
323848004269	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
323848004270	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848004271	dimer interface [polypeptide binding]; other site
323848004272	phosphorylation site [posttranslational modification]
323848004273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848004274	ATP binding site [chemical binding]; other site
323848004275	Mg2+ binding site [ion binding]; other site
323848004276	G-X-G motif; other site
323848004277	Response regulator receiver domain; Region: Response_reg; pfam00072
323848004278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848004279	active site
323848004280	phosphorylation site [posttranslational modification]
323848004281	intermolecular recognition site; other site
323848004282	dimerization interface [polypeptide binding]; other site
323848004283	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
323848004284	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
323848004285	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
323848004286	putative ligand binding site [chemical binding]; other site
323848004287	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
323848004288	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
323848004289	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
323848004290	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848004291	metal binding site [ion binding]; metal-binding site
323848004292	active site
323848004293	I-site; other site
323848004294	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848004295	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14618
323848004296	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
323848004297	active site
323848004298	intersubunit interface [polypeptide binding]; other site
323848004299	catalytic residue [active]
323848004300	CrcB-like protein; Region: CRCB; cl09114
323848004301	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
323848004302	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
323848004303	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185
323848004304	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185
323848004305	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
323848004306	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185
323848004307	Autotransporter beta-domain; Region: Autotransporter; cl02365
323848004308	putative transposase OrfB; Reviewed; Region: PHA02517
323848004309	Integrase core domain; Region: rve; cl01316
323848004310	putative transposase OrfB; Reviewed; Region: PHA02517
323848004311	Integrase core domain; Region: rve; cl01316
323848004312	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848004313	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
323848004314	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
323848004315	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
323848004316	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
323848004317	putative NAD(P) binding site [chemical binding]; other site
323848004318	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
323848004319	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
323848004320	putative hydrophobic ligand binding site [chemical binding]; other site
323848004321	protein interface [polypeptide binding]; other site
323848004322	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
323848004323	Protein of unknown function (DUF1749); Region: DUF1749; pfam08538
323848004324	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848004325	binding surface
323848004326	TPR motif; other site
323848004327	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848004328	binding surface
323848004329	TPR motif; other site
323848004330	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848004331	binding surface
323848004332	TPR motif; other site
323848004333	YCII-related domain; Region: YCII; cl00999
323848004334	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
323848004335	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
323848004336	Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525
323848004337	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685
323848004338	RNA binding site [nucleotide binding]; other site
323848004339	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
323848004340	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
323848004341	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
323848004342	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
323848004343	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
323848004344	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
323848004345	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
323848004346	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
323848004347	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
323848004348	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
323848004349	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
323848004350	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
323848004351	NlpC/P60 family; Region: NLPC_P60; cl11438
323848004352	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
323848004353	metal binding site [ion binding]; metal-binding site
323848004354	Succinylarginine dihydrolase; Region: AstB; cl01511
323848004355	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
323848004356	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
323848004357	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085
323848004358	active site
323848004359	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
323848004360	CsbD-like; Region: CsbD; cl01272
323848004361	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
323848004362	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
323848004363	active site
323848004364	HIGH motif; other site
323848004365	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
323848004366	active site
323848004367	KMSKS motif; other site
323848004368	PAS fold; Region: PAS_7; pfam12860
323848004369	PAS domain S-box; Region: sensory_box; TIGR00229
323848004370	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848004371	putative active site [active]
323848004372	heme pocket [chemical binding]; other site
323848004373	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848004374	metal binding site [ion binding]; metal-binding site
323848004375	active site
323848004376	I-site; other site
323848004377	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848004378	Flagellar regulator YcgR; Region: YcgR; pfam07317
323848004379	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
323848004380	PilZ domain; Region: PilZ; cl01260
323848004381	multicopper oxidase; Provisional; Region: PRK10965
323848004382	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
323848004383	Multicopper oxidase; Region: Cu-oxidase; cl14658
323848004384	Cytochrome c; Region: Cytochrom_C; cl11414
323848004385	Protein of unknown function (DUF330); Region: DUF330; cl01135
323848004386	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
323848004387	mce related protein; Region: MCE; cl03606
323848004388	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
323848004389	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848004390	Walker A/P-loop; other site
323848004391	ATP binding site [chemical binding]; other site
323848004392	Q-loop/lid; other site
323848004393	ABC transporter signature motif; other site
323848004394	Walker B; other site
323848004395	D-loop; other site
323848004396	H-loop/switch region; other site
323848004397	Domain of unknown function DUF140; Region: DUF140; cl00510
323848004398	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
323848004399	phosphoenolpyruvate synthase; Validated; Region: PRK06241
323848004400	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
323848004401	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
323848004402	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
323848004403	Proteobacterial; Region: dnaQ_proteo; TIGR01406
323848004404	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
323848004405	active site
323848004406	substrate binding site [chemical binding]; other site
323848004407	catalytic site [active]
323848004408	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
323848004409	RNA/DNA hybrid binding site [nucleotide binding]; other site
323848004410	active site
323848004411	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848004412	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
323848004413	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
323848004414	putative active site [active]
323848004415	transaldolase; Provisional; Region: PRK03903
323848004416	catalytic residue [active]
323848004417	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848004418	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
323848004419	DoxX; Region: DoxX; cl00976
323848004420	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
323848004421	putative active site [active]
323848004422	Predicted transcriptional regulator [Transcription]; Region: COG2345
323848004423	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848004424	V4R domain; Region: V4R; cl08369
323848004425	Membrane transport protein; Region: Mem_trans; cl09117
323848004426	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848004427	S-adenosylmethionine binding site [chemical binding]; other site
323848004428	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
323848004429	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848004430	Nitrogen regulatory protein P-II; Region: P-II; cl00412
323848004431	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
323848004432	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
323848004433	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
323848004434	Outer membrane efflux protein; Region: OEP; pfam02321
323848004435	Outer membrane efflux protein; Region: OEP; pfam02321
323848004436	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848004437	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848004438	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848004439	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848004440	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
323848004441	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
323848004442	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323848004443	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
323848004444	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
323848004445	BON domain; Region: BON; cl02771
323848004446	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
323848004447	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
323848004448	ATP synthase; Region: ATP-synt; cl00365
323848004449	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
323848004450	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848004451	Walker A motif; other site
323848004452	ATP binding site [chemical binding]; other site
323848004453	Walker B motif; other site
323848004454	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
323848004455	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
323848004456	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
323848004457	ATP synthase subunit C; Region: ATP-synt_C; cl00466
323848004458	ATP synthase A chain; Region: ATP-synt_A; cl00413
323848004459	N-ATPase, AtpR subunit; Region: AtpR; cl11871
323848004460	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
323848004461	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
323848004462	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
323848004463	alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305
323848004464	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
323848004465	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
323848004466	alpha subunit interaction interface [polypeptide binding]; other site
323848004467	Walker A motif; other site
323848004468	ATP binding site [chemical binding]; other site
323848004469	Walker B motif; other site
323848004470	inhibitor binding site; inhibition site
323848004471	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
323848004472	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
323848004473	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
323848004474	Beta-Casp domain; Region: Beta-Casp; pfam10996
323848004475	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
323848004476	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
323848004477	Zn2+ binding site [ion binding]; other site
323848004478	Mg2+ binding site [ion binding]; other site
323848004479	HupF/HypC family; Region: HupF_HypC; cl00394
323848004480	Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418
323848004481	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
323848004482	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409
323848004483	Hydrogenase formation hypA family; Region: HypD; cl12072
323848004484	Acylphosphatase; Region: Acylphosphatase; cl00551
323848004485	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
323848004486	HypF finger; Region: zf-HYPF; pfam07503
323848004487	HypF finger; Region: zf-HYPF; pfam07503
323848004488	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
323848004489	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
323848004490	dimerization interface [polypeptide binding]; other site
323848004491	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
323848004492	ATP binding site [chemical binding]; other site
323848004493	NADH dehydrogenase subunit E; Provisional; Region: PRK12373
323848004494	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
323848004495	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
323848004496	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
323848004497	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
323848004498	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
323848004499	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
323848004500	catalytic loop [active]
323848004501	iron binding site [ion binding]; other site
323848004502	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
323848004503	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419
323848004504	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417
323848004505	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
323848004506	nickel binding site [ion binding]; other site
323848004507	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
323848004508	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848004509	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848004510	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
323848004511	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
323848004512	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848004513	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848004514	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848004515	PEP-CTERM motif; Region: VPEP; pfam07589
323848004516	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
323848004517	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323848004518	Ligand Binding Site [chemical binding]; other site
323848004519	multicopper oxidase; Provisional; Region: PRK10965
323848004520	Multicopper oxidase; Region: Cu-oxidase; cl14658
323848004521	Multicopper oxidase; Region: Cu-oxidase; cl14658
323848004522	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
323848004523	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
323848004524	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
323848004525	dimerization interface [polypeptide binding]; other site
323848004526	putative DNA binding site [nucleotide binding]; other site
323848004527	putative Zn2+ binding site [ion binding]; other site
323848004528	YeeE/YedE family (DUF395); Region: DUF395; cl01018
323848004529	YeeE/YedE family (DUF395); Region: DUF395; cl01018
323848004530	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
323848004531	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848004532	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848004533	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
323848004534	proposed catalytic triad [active]
323848004535	active site nucleophile [active]
323848004536	Ion transport protein; Region: Ion_trans; pfam00520
323848004537	Ion channel; Region: Ion_trans_2; cl11596
323848004538	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
323848004539	Integrase core domain; Region: rve; cl01316
323848004540	Integrase core domain; Region: rve; cl01316
323848004541	IS2 transposase TnpB; Reviewed; Region: PRK09409
323848004542	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848004543	Integrase core domain; Region: rve; cl01316
323848004544	putative transposase OrfB; Reviewed; Region: PHA02517
323848004545	Integrase core domain; Region: rve; cl01316
323848004546	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
323848004547	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
323848004548	active site
323848004549	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
323848004550	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
323848004551	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
323848004552	Chain length determinant protein; Region: Wzz; cl01623
323848004553	Phage integrase family; Region: Phage_integrase; pfam00589
323848004554	C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182
323848004555	DNA binding site [nucleotide binding]
323848004556	active site
323848004557	Int/Topo IB signature motif; other site
323848004558	catalytic residues [active]
323848004559	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
323848004560	putative active site [active]
323848004561	metal binding site [ion binding]; metal-binding site
323848004562	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
323848004563	Phosphotransferase enzyme family; Region: APH; pfam01636
323848004564	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
323848004565	substrate binding site [chemical binding]; other site
323848004566	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
323848004567	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
323848004568	motif II; other site
323848004569	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848004570	PAS fold; Region: PAS_3; pfam08447
323848004571	putative active site [active]
323848004572	heme pocket [chemical binding]; other site
323848004573	PAS fold; Region: PAS_4; pfam08448
323848004574	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848004575	metal binding site [ion binding]; metal-binding site
323848004576	active site
323848004577	I-site; other site
323848004578	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848004579	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
323848004580	Protein of unknown function (DUF2591); Region: DUF2591; cl11584
323848004581	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
323848004582	putative active site [active]
323848004583	catalytic site [active]
323848004584	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
323848004585	putative active site [active]
323848004586	catalytic site [active]
323848004587	Protein of unknown function, DUF488; Region: DUF488; cl01246
323848004588	CreA protein; Region: CreA; cl01154
323848004589	CHRD domain; Region: CHRD; cl06473
323848004590	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
323848004591	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
323848004592	active site
323848004593	FMN binding site [chemical binding]; other site
323848004594	substrate binding site [chemical binding]; other site
323848004595	homotetramer interface [polypeptide binding]; other site
323848004596	catalytic residue [active]
323848004597	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
323848004598	Cytochrome c; Region: Cytochrom_C; cl11414
323848004599	Cytochrome c; Region: Cytochrom_C; cl11414
323848004600	Cytochrome c; Region: Cytochrom_C; cl11414
323848004601	flagellar assembly protein H; Validated; Region: fliH; PRK06032
323848004602	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
323848004603	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848004604	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
323848004605	GST_C family, ECM4-like subfamily; composed of predominantly uncharacterized and taxonomically diverse proteins with similarity to the translation product of the Saccharomyces cerevisiae gene ECM4.  ECM4, a gene of unknown function, is involved in cell...; Region: GST_C_ECM4_like; cd03190
323848004606	Integrase core domain; Region: rve; cl01316
323848004607	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
323848004608	Outer membrane efflux protein; Region: OEP; pfam02321
323848004609	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
323848004610	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323848004611	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
323848004612	Predicted membrane protein [Function unknown]; Region: COG4267
323848004613	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_3; cd03813
323848004614	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
323848004615	Bacteriophage lambda tail assembly protein I; Region: Lambda_tail_I; cl01945
323848004616	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
323848004617	TM1410 hypothetical-related protein; Region: DUF297; cl00997
323848004618	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
323848004619	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
323848004620	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
323848004621	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848004622	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
323848004623	substrate binding site [chemical binding]; other site
323848004624	dimerization interface [polypeptide binding]; other site
323848004625	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
323848004626	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
323848004627	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
323848004628	Walker A/P-loop; other site
323848004629	ATP binding site [chemical binding]; other site
323848004630	Q-loop/lid; other site
323848004631	ABC transporter signature motif; other site
323848004632	Walker B; other site
323848004633	D-loop; other site
323848004634	H-loop/switch region; other site
323848004635	L-aspartate oxidase; Provisional; Region: PRK09077
323848004636	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848004637	domain; Region: Succ_DH_flav_C; pfam02910
323848004638	Cation efflux family; Region: Cation_efflux; cl00316
323848004639	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
323848004640	dimerization interface [polypeptide binding]; other site
323848004641	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
323848004642	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323848004643	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
323848004644	DNA binding residues [nucleotide binding]
323848004645	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
323848004646	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
323848004647	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
323848004648	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
323848004649	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
323848004650	protein binding site [polypeptide binding]; other site
323848004651	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
323848004652	protein binding site [polypeptide binding]; other site
323848004653	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
323848004654	GTP-binding protein LepA; Provisional; Region: PRK05433
323848004655	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
323848004656	G1 box; other site
323848004657	putative GEF interaction site [polypeptide binding]; other site
323848004658	GTP/Mg2+ binding site [chemical binding]; other site
323848004659	Switch I region; other site
323848004660	G2 box; other site
323848004661	G3 box; other site
323848004662	Switch II region; other site
323848004663	G4 box; other site
323848004664	G5 box; other site
323848004665	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699
323848004666	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
323848004667	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
323848004668	signal peptidase I; Provisional; Region: PRK10861
323848004669	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
323848004670	Catalytic site [active]
323848004671	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
323848004672	ribonuclease III; Reviewed; Region: rnc; PRK00102
323848004673	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
323848004674	dimerization interface [polypeptide binding]; other site
323848004675	active site
323848004676	metal binding site [ion binding]; metal-binding site
323848004677	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048
323848004678	dsRNA binding site [nucleotide binding]; other site
323848004679	GTPase Era; Reviewed; Region: era; PRK00089
323848004680	Era subfamily.  Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria.  It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163
323848004681	G1 box; other site
323848004682	GTP/Mg2+ binding site [chemical binding]; other site
323848004683	Switch I region; other site
323848004684	G2 box; other site
323848004685	Switch II region; other site
323848004686	G3 box; other site
323848004687	G4 box; other site
323848004688	G5 box; other site
323848004689	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098
323848004690	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
323848004691	Recombination protein O N terminal; Region: RecO_N; pfam11967
323848004692	Recombination protein O C terminal; Region: RecO_C; pfam02565
323848004693	Domain of unknown function DUF; Region: DUF202; cl09954
323848004694	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
323848004695	active site
323848004696	hydrophilic channel; other site
323848004697	dimerization interface [polypeptide binding]; other site
323848004698	catalytic residues [active]
323848004699	active site lid [active]
323848004700	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
323848004701	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
323848004702	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
323848004703	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464
323848004704	putative dimer interface [polypeptide binding]; other site
323848004705	Uncharacterized conserved protein [Function unknown]; Region: COG5316
323848004706	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
323848004707	Ligand binding site [chemical binding]; other site
323848004708	Putative Catalytic site [active]
323848004709	DXD motif; other site
323848004710	GtrA-like protein; Region: GtrA; cl00971
323848004711	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961
323848004712	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
323848004713	putative exosortase-affiliated protein, TIGR04073 family; Region: exo_TIGR04073
323848004714	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
323848004715	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
323848004716	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
323848004717	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
323848004718	catalytic residues [active]
323848004719	TypA (tyrosine phosphorylated protein A)/BipA subfamily.  BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants.  BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891
323848004720	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
323848004721	G1 box; other site
323848004722	putative GEF interaction site [polypeptide binding]; other site
323848004723	GTP/Mg2+ binding site [chemical binding]; other site
323848004724	Switch I region; other site
323848004725	G2 box; other site
323848004726	G3 box; other site
323848004727	Switch II region; other site
323848004728	G4 box; other site
323848004729	G5 box; other site
323848004730	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
323848004731	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a...; Region: BipA_TypA_C; cd03710
323848004732	comEA protein; Region: comE; TIGR01259
323848004733	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
323848004734	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
323848004735	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323848004736	ligand binding site [chemical binding]; other site
323848004737	flexible hinge region; other site
323848004738	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
323848004739	putative switch regulator; other site
323848004740	non-specific DNA interactions [nucleotide binding]; other site
323848004741	DNA binding site [nucleotide binding]
323848004742	sequence specific DNA binding site [nucleotide binding]; other site
323848004743	putative cAMP binding site [chemical binding]; other site
323848004744	Rrf2 family protein; Region: rrf2_super; TIGR00738
323848004745	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848004746	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
323848004747	Subunit III/VIIa interface [polypeptide binding]; other site
323848004748	Phospholipid binding site [chemical binding]; other site
323848004749	Subunit I/III interface [polypeptide binding]; other site
323848004750	Subunit III/VIb interface [polypeptide binding]; other site
323848004751	Subunit III/VIa interface; other site
323848004752	Subunit III/Vb interface [polypeptide binding]; other site
323848004753	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
323848004754	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
323848004755	Subunit I/III interface [polypeptide binding]; other site
323848004756	D-pathway; other site
323848004757	Subunit I/VIIc interface [polypeptide binding]; other site
323848004758	Subunit I/IV interface [polypeptide binding]; other site
323848004759	Subunit I/II interface [polypeptide binding]; other site
323848004760	Low-spin heme (heme a) binding site [chemical binding]; other site
323848004761	Subunit I/VIIa interface [polypeptide binding]; other site
323848004762	Subunit I/VIa interface [polypeptide binding]; other site
323848004763	Dimer interface; other site
323848004764	Putative water exit pathway; other site
323848004765	Binuclear center (heme a3/CuB) [ion binding]; other site
323848004766	K-pathway; other site
323848004767	Subunit I/Vb interface [polypeptide binding]; other site
323848004768	Putative proton exit pathway; other site
323848004769	Subunit I/VIb interface; other site
323848004770	Subunit I/VIc interface [polypeptide binding]; other site
323848004771	Electron transfer pathway; other site
323848004772	Subunit I/VIIIb interface [polypeptide binding]; other site
323848004773	Subunit I/VIIb interface [polypeptide binding]; other site
323848004774	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
323848004775	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
323848004776	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
323848004777	Cytochrome c; Region: Cytochrom_C; cl11414
323848004778	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323848004779	COQ9; Region: COQ9; cl14819
323848004780	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
323848004781	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
323848004782	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
323848004783	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
323848004784	putative active site [active]
323848004785	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
323848004786	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
323848004787	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
323848004788	putative active site [active]
323848004789	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
323848004790	substrate binding site [chemical binding]; other site
323848004791	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
323848004792	PAS fold; Region: PAS_4; pfam08448
323848004793	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848004794	putative active site [active]
323848004795	heme pocket [chemical binding]; other site
323848004796	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
323848004797	hydrophobic ligand binding site; other site
323848004798	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
323848004799	active site
323848004800	dimerization interface [polypeptide binding]; other site
323848004801	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
323848004802	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
323848004803	active site
323848004804	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
323848004805	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
323848004806	putative active site [active]
323848004807	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
323848004808	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192
323848004809	substrate binding site [chemical binding]; other site
323848004810	ATP binding site [chemical binding]; other site
323848004811	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323848004812	active site
323848004813	nucleotide binding site [chemical binding]; other site
323848004814	HIGH motif; other site
323848004815	KMSKS motif; other site
323848004816	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
323848004817	active site
323848004818	motif I; other site
323848004819	motif II; other site
323848004820	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
323848004821	classical (c) SDRs; Region: SDR_c; cd05233
323848004822	NAD(P) binding site [chemical binding]; other site
323848004823	active site
323848004824	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
323848004825	UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449
323848004826	putative ADP-binding pocket [chemical binding]; other site
323848004827	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
323848004828	dimer interface [polypeptide binding]; other site
323848004829	active site
323848004830	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
323848004831	Family of unknown function (DUF490); Region: DUF490; pfam04357
323848004832	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
323848004833	Surface antigen; Region: Bac_surface_Ag; cl03097
323848004834	FtsH Extracellular; Region: FtsH_ext; pfam06480
323848004835	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
323848004836	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848004837	Walker A motif; other site
323848004838	ATP binding site [chemical binding]; other site
323848004839	Walker B motif; other site
323848004840	arginine finger; other site
323848004841	Peptidase family M41; Region: Peptidase_M41; pfam01434
323848004842	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
323848004843	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
323848004844	ATP binding site [chemical binding]; other site
323848004845	Mg++ binding site [ion binding]; other site
323848004846	motif III; other site
323848004847	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323848004848	nucleotide binding region [chemical binding]; other site
323848004849	ATP-binding site [chemical binding]; other site
323848004850	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454
323848004851	apolar tunnel; other site
323848004852	heme binding site [chemical binding]; other site
323848004853	dimerization interface [polypeptide binding]; other site
323848004854	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017
323848004855	catalytic triad [active]
323848004856	DNA repair protein RadA; Provisional; Region: PRK11823
323848004857	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
323848004858	Walker A motif/ATP binding site; other site
323848004859	ATP binding site [chemical binding]; other site
323848004860	Walker B motif; other site
323848004861	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
323848004862	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808
323848004863	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
323848004864	active site
323848004865	FMN binding site [chemical binding]; other site
323848004866	substrate binding site [chemical binding]; other site
323848004867	3Fe-4S cluster binding site [ion binding]; other site
323848004868	Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977
323848004869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323848004870	putative substrate translocation pore; other site
323848004871	Pirin-related protein [General function prediction only]; Region: COG1741
323848004872	Cupin domain; Region: Cupin_2; cl09118
323848004873	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
323848004874	TilS substrate binding domain; Region: TilS; pfam09179
323848004875	B3/4 domain; Region: B3_4; cl11458
323848004876	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
323848004877	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
323848004878	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848004879	Walker A/P-loop; other site
323848004880	ATP binding site [chemical binding]; other site
323848004881	Q-loop/lid; other site
323848004882	ABC transporter signature motif; other site
323848004883	Walker B; other site
323848004884	D-loop; other site
323848004885	H-loop/switch region; other site
323848004886	ABC transporter; Region: ABC_tran_2; pfam12848
323848004887	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
323848004888	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
323848004889	amidase catalytic site [active]
323848004890	Zn binding residues [ion binding]; other site
323848004891	substrate binding site [chemical binding]; other site
323848004892	octaprenyl diphosphate synthase; Provisional; Region: PRK10888
323848004893	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
323848004894	substrate binding pocket [chemical binding]; other site
323848004895	chain length determination region; other site
323848004896	substrate-Mg2+ binding site; other site
323848004897	catalytic residues [active]
323848004898	aspartate-rich region 1; other site
323848004899	active site lid residues [active]
323848004900	aspartate-rich region 2; other site
323848004901	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
323848004902	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
323848004903	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
323848004904	GTP1/OBG; Region: GTP1_OBG; pfam01018
323848004905	Obg subfamily.  The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation.  Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
323848004906	G1 box; other site
323848004907	GTP/Mg2+ binding site [chemical binding]; other site
323848004908	Switch I region; other site
323848004909	G2 box; other site
323848004910	G3 box; other site
323848004911	Switch II region; other site
323848004912	G4 box; other site
323848004913	G5 box; other site
323848004914	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
323848004915	Protein of unknown function, DUF393; Region: DUF393; cl01136
323848004916	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
323848004917	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
323848004918	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
323848004919	The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export.  They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins.  The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228
323848004920	Walker A/P-loop; other site
323848004921	ATP binding site [chemical binding]; other site
323848004922	Q-loop/lid; other site
323848004923	ABC transporter signature motif; other site
323848004924	Walker B; other site
323848004925	D-loop; other site
323848004926	H-loop/switch region; other site
323848004927	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
323848004928	Siderophore biosynthesis protein domain; Region: AlcB; pfam10331
323848004929	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
323848004930	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
323848004931	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323848004932	N-terminal plug; other site
323848004933	ligand-binding site [chemical binding]; other site
323848004934	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
323848004935	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
323848004936	substrate binding pocket [chemical binding]; other site
323848004937	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
323848004938	peptide synthase; Provisional; Region: PRK12316
323848004939	Condensation domain; Region: Condensation; cl09290
323848004940	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848004941	Phosphopantetheine attachment site; Region: PP-binding; cl09936
323848004942	Condensation domain; Region: Condensation; cl09290
323848004943	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
323848004944	Condensation domain; Region: Condensation; cl09290
323848004945	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
323848004946	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848004947	Phosphopantetheine attachment site; Region: PP-binding; cl09936
323848004948	peptide synthase; Provisional; Region: PRK12467
323848004949	Condensation domain; Region: Condensation; cl09290
323848004950	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848004951	Phosphopantetheine attachment site; Region: PP-binding; cl09936
323848004952	Condensation domain; Region: Condensation; cl09290
323848004953	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
323848004954	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848004955	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848004956	Phosphopantetheine attachment site; Region: PP-binding; cl09936
323848004957	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
323848004958	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
323848004959	active site
323848004960	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
323848004961	Acyl transferase domain; Region: Acyl_transf_1; cl08282
323848004962	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
323848004963	putative NADP binding site [chemical binding]; other site
323848004964	active site
323848004965	Phosphopantetheine attachment site; Region: PP-binding; cl09936
323848004966	acyl-CoA synthetase; Validated; Region: PRK05850
323848004967	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848004968	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848004969	Phosphopantetheine attachment site; Region: PP-binding; cl09936
323848004970	peptide synthase; Provisional; Region: PRK12467
323848004971	Condensation domain; Region: Condensation; cl09290
323848004972	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848004973	Phosphopantetheine attachment site; Region: PP-binding; cl09936
323848004974	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
323848004975	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
323848004976	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
323848004977	Thioesterase domain; Region: Thioesterase; pfam00975
323848004978	MbtH-like protein; Region: MbtH; cl01279
323848004979	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
323848004980	Integrase core domain; Region: rve; cl01316
323848004981	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
323848004982	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323848004983	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
323848004984	NodT family; Region: outer_NodT; TIGR01845
323848004985	Outer membrane efflux protein; Region: OEP; pfam02321
323848004986	Outer membrane efflux protein; Region: OEP; pfam02321
323848004987	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323848004988	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323848004989	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
323848004990	Protein export membrane protein; Region: SecD_SecF; cl14618
323848004991	gamma-glutamyl kinase; Provisional; Region: PRK05429
323848004992	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
323848004993	nucleotide binding site [chemical binding]; other site
323848004994	homotetrameric interface [polypeptide binding]; other site
323848004995	putative phosphate binding site [ion binding]; other site
323848004996	putative allosteric binding site; other site
323848004997	PUA domain; Region: PUA; cl00607
323848004998	CNP1-like family; Region: CNP1; pfam08750
323848004999	Protein of unknown function (DUF3501); Region: DUF3501; pfam12007
323848005000	CitB domain protein; Region: CitB; TIGR02484
323848005001	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
323848005002	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
323848005003	binuclear metal center [ion binding]; other site
323848005004	glycerate dehydrogenase; Provisional; Region: PRK06487
323848005005	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848005006	Predicted permeases [General function prediction only]; Region: RarD; COG2962
323848005007	aspartate aminotransferase; Provisional; Region: PRK08361
323848005008	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323848005009	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848005010	homodimer interface [polypeptide binding]; other site
323848005011	catalytic residue [active]
323848005012	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
323848005013	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350
323848005014	trimer interface [polypeptide binding]; other site
323848005015	active site
323848005016	substrate binding site [chemical binding]; other site
323848005017	CoA binding site [chemical binding]; other site
323848005018	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
323848005019	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
323848005020	metal binding site [ion binding]; metal-binding site
323848005021	dimer interface [polypeptide binding]; other site
323848005022	HemK family putative methylases; Region: hemK_fam; TIGR00536
323848005023	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848005024	S-adenosylmethionine binding site [chemical binding]; other site
323848005025	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
323848005026	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
323848005027	PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556
323848005028	probable active site [active]
323848005029	recombination protein RecR; Reviewed; Region: recR; PRK00076
323848005030	RecR protein; Region: RecR; pfam02132
323848005031	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
323848005032	putative active site [active]
323848005033	putative metal-binding site [ion binding]; other site
323848005034	tetramer interface [polypeptide binding]; other site
323848005035	Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494
323848005036	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969
323848005037	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848005038	Walker A motif; other site
323848005039	ATP binding site [chemical binding]; other site
323848005040	Walker B motif; other site
323848005041	arginine finger; other site
323848005042	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
323848005043	chloroplast protein import component Toc86/159, G and M domains; Region: 3a0901s04IAP86; TIGR00993
323848005044	Response regulator receiver domain; Region: Response_reg; pfam00072
323848005045	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848005046	active site
323848005047	phosphorylation site [posttranslational modification]
323848005048	intermolecular recognition site; other site
323848005049	dimerization interface [polypeptide binding]; other site
323848005050	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848005051	metal binding site [ion binding]; metal-binding site
323848005052	active site
323848005053	I-site; other site
323848005054	Response regulator receiver domain; Region: Response_reg; pfam00072
323848005055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848005056	active site
323848005057	phosphorylation site [posttranslational modification]
323848005058	intermolecular recognition site; other site
323848005059	dimerization interface [polypeptide binding]; other site
323848005060	PAS domain S-box; Region: sensory_box; TIGR00229
323848005061	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
323848005062	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
323848005063	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573
323848005064	RNA binding site [nucleotide binding]; other site
323848005065	active site
323848005066	Ribosome-binding factor A; Region: RBFA; cl00542
323848005067	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
323848005068	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
323848005069	translation initiation factor IF-2; Region: IF-2; TIGR00487
323848005070	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
323848005071	IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily.  IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits.  As seen in other GTPases...; Region: IF2_eIF5B; cd01887
323848005072	G1 box; other site
323848005073	putative GEF interaction site [polypeptide binding]; other site
323848005074	GTP/Mg2+ binding site [chemical binding]; other site
323848005075	Switch I region; other site
323848005076	G2 box; other site
323848005077	G3 box; other site
323848005078	Switch II region; other site
323848005079	G4 box; other site
323848005080	G5 box; other site
323848005081	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702
323848005082	Translation-initiation factor 2; Region: IF-2; pfam11987
323848005083	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692
323848005084	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
323848005085	NusA N-terminal domain; Region: NusA_N; pfam08529
323848005086	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455
323848005087	RNA binding site [nucleotide binding]; other site
323848005088	homodimer interface [polypeptide binding]; other site
323848005089	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
323848005090	G-X-X-G motif; other site
323848005091	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
323848005092	ribosome maturation protein RimP; Reviewed; Region: PRK00092
323848005093	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
323848005094	YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold.  The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734
323848005095	Sm1 motif; other site
323848005096	predicted subunit interaction site [polypeptide binding]; other site
323848005097	RNA binding pocket [nucleotide binding]; other site
323848005098	Sm2 motif; other site
323848005099	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
323848005100	acyl-CoA synthetase; Validated; Region: PRK07868
323848005101	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848005102	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848005103	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
323848005104	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
323848005105	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
323848005106	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
323848005107	domain; Region: GreA_GreB_N; pfam03449
323848005108	C-term; Region: GreA_GreB; pfam01272
323848005109	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
323848005110	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
323848005111	RmuC family; Region: RmuC; pfam02646
323848005112	Protein of unknown function, DUF488; Region: DUF488; cl01246
323848005113	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848005114	TPR motif; other site
323848005115	binding surface
323848005116	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
323848005117	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
323848005118	active site
323848005119	HIGH motif; other site
323848005120	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
323848005121	KMSKS motif; other site
323848005122	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
323848005123	tRNA binding surface [nucleotide binding]; other site
323848005124	anticodon binding site; other site
323848005125	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848005126	binding surface
323848005127	TPR motif; other site
323848005128	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848005129	binding surface
323848005130	TPR motif; other site
323848005131	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
323848005132	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
323848005133	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
323848005134	substrate binding site [chemical binding]; other site
323848005135	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
323848005136	substrate binding site [chemical binding]; other site
323848005137	Peptidase family M48; Region: Peptidase_M48; cl12018
323848005138	Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498
323848005139	active site
323848005140	catalytic triad [active]
323848005141	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
323848005142	active site
323848005143	catalytic residues [active]
323848005144	General secretion pathway, M protein; Region: GspM; cl01222
323848005145	GspL cytoplasmic actin-ATPase-like region; Region: GspL; pfam05134
323848005146	GspL periplasmic domain; Region: GspL_C; cl14909
323848005147	General secretion pathway protein K; Region: GspK; pfam03934
323848005148	Pseudopilin GspJ; Region: GspJ; pfam11612
323848005149	Bacterial type II secretion system protein I/J; Region: GSPII_IJ; pfam02501
323848005150	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
323848005151	Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
323848005152	Type II transport protein GspH; Region: GspH; pfam12019
323848005153	Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
323848005154	Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334
323848005155	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
323848005156	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
323848005157	proposed catalytic triad [active]
323848005158	active site nucleophile [active]
323848005159	general secretion pathway protein D; Region: type_II_gspD; TIGR02517
323848005160	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
323848005161	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
323848005162	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
323848005163	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
323848005164	general secretory pathway protein E; Region: type_II_gspE; TIGR02533
323848005165	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
323848005166	Walker A motif; other site
323848005167	ATP binding site [chemical binding]; other site
323848005168	Walker B motif; other site
323848005169	general secretion pathway protein F; Region: GspF; TIGR02120
323848005170	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
323848005171	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
323848005172	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
323848005173	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
323848005174	homodimer interface [polypeptide binding]; other site
323848005175	substrate-cofactor binding pocket; other site
323848005176	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848005177	catalytic residue [active]
323848005178	amidophosphoribosyltransferase; Provisional; Region: PRK09246
323848005179	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
323848005180	active site
323848005181	tetramer interface [polypeptide binding]; other site
323848005182	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
323848005183	Colicin V production protein; Region: Colicin_V; cl00567
323848005184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
323848005185	Sporulation related domain; Region: SPOR; cl10051
323848005186	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
323848005187	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323848005188	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323848005189	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
323848005190	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
323848005191	tryptophan synthase; Region: PLN02591
323848005192	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724
323848005193	substrate binding site [chemical binding]; other site
323848005194	active site
323848005195	catalytic residues [active]
323848005196	heterodimer interface [polypeptide binding]; other site
323848005197	tryptophan synthase, beta chain; Region: PLN02618
323848005198	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
323848005199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848005200	catalytic residue [active]
323848005201	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405
323848005202	active site
323848005203	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
323848005204	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570
323848005205	dimerization interface 3.5A [polypeptide binding]; other site
323848005206	active site
323848005207	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
323848005208	FimV N-terminal domain; Region: FimV_core; TIGR03505
323848005209	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
323848005210	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848005211	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
323848005212	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
323848005213	isocitrate dehydrogenase; Validated; Region: PRK06451
323848005214	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577
323848005215	substrate binding site [chemical binding]; other site
323848005216	Entericidin EcnA/B family; Region: Entericidin; cl02322
323848005217	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
323848005218	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
323848005219	substrate binding site [chemical binding]; other site
323848005220	ligand binding site [chemical binding]; other site
323848005221	MFS_1 like family; Region: MFS_1_like; pfam12832
323848005222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323848005223	putative substrate translocation pore; other site
323848005224	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959
323848005225	TIGR03440 family protein; Region: unchr_TIGR03440
323848005226	DinB superfamily; Region: DinB_2; cl00986
323848005227	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
323848005228	probable methyltransferase; Region: TIGR03438
323848005229	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
323848005230	Integral membrane protein TerC family; Region: TerC; cl10468
323848005231	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
323848005232	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848005233	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
323848005234	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323848005235	putative transcriptional regulator; Provisional; Region: PRK11640
323848005236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848005237	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
323848005238	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
323848005239	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
323848005240	active site
323848005241	HIGH motif; other site
323848005242	KMSKS motif; other site
323848005243	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
323848005244	tRNA binding surface [nucleotide binding]; other site
323848005245	anticodon binding site; other site
323848005246	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
323848005247	dimer interface [polypeptide binding]; other site
323848005248	putative tRNA-binding site [nucleotide binding]; other site
323848005249	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
323848005250	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
323848005251	putative NAD(P) binding site [chemical binding]; other site
323848005252	putative substrate binding site [chemical binding]; other site
323848005253	catalytic Zn binding site [ion binding]; other site
323848005254	structural Zn binding site [ion binding]; other site
323848005255	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
323848005256	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
323848005257	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
323848005258	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
323848005259	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
323848005260	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
323848005261	dimer interface [polypeptide binding]; other site
323848005262	active site
323848005263	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
323848005264	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895
323848005265	aspartate kinase; Reviewed; Region: PRK06635
323848005266	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
323848005267	putative nucleotide binding site [chemical binding]; other site
323848005268	putative catalytic residues [active]
323848005269	putative Mg ion binding site [ion binding]; other site
323848005270	putative aspartate binding site [chemical binding]; other site
323848005271	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
323848005272	putative allosteric regulatory site; other site
323848005273	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
323848005274	putative allosteric regulatory residue; other site
323848005275	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323848005276	non-specific DNA binding site [nucleotide binding]; other site
323848005277	salt bridge; other site
323848005278	sequence-specific DNA binding site [nucleotide binding]; other site
323848005279	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
323848005280	FeS/SAM binding site; other site
323848005281	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
323848005282	active site
323848005283	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017
323848005284	catalytic triad [active]
323848005285	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
323848005286	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
323848005287	putative active site [active]
323848005288	PhoH-like protein; Region: PhoH; cl12134
323848005289	replicative DNA helicase; Region: DnaB; TIGR00665
323848005290	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
323848005291	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
323848005292	Walker A motif; other site
323848005293	ATP binding site [chemical binding]; other site
323848005294	Walker B motif; other site
323848005295	DNA binding loops [nucleotide binding]
323848005296	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
323848005297	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
323848005298	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
323848005299	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
323848005300	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
323848005301	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
323848005302	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
323848005303	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
323848005304	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
323848005305	ribonuclease R; Region: RNase_R; TIGR02063
323848005306	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
323848005307	RNB domain; Region: RNB; pfam00773
323848005308	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471
323848005309	RNA binding site [nucleotide binding]; other site
323848005310	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
323848005311	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
323848005312	PAS domain S-box; Region: sensory_box; TIGR00229
323848005313	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848005314	metal binding site [ion binding]; metal-binding site
323848005315	active site
323848005316	I-site; other site
323848005317	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848005318	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
323848005319	Tetramer interface [polypeptide binding]; other site
323848005320	Active site [active]
323848005321	FMN-binding site [chemical binding]; other site
323848005322	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
323848005323	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
323848005324	putative NAD(P) binding site [chemical binding]; other site
323848005325	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
323848005326	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
323848005327	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433
323848005328	interface (dimer of trimers) [polypeptide binding]; other site
323848005329	Substrate-binding/catalytic site; other site
323848005330	Zn-binding sites [ion binding]; other site
323848005331	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
323848005332	dimerization interface [polypeptide binding]; other site
323848005333	active site
323848005334	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209
323848005335	folate binding site [chemical binding]; other site
323848005336	NADP+ binding site [chemical binding]; other site
323848005337	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
323848005338	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
323848005339	active site
323848005340	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
323848005341	dimer interface [polypeptide binding]; other site
323848005342	catalytic residues [active]
323848005343	substrate binding site [chemical binding]; other site
323848005344	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
323848005345	trimer interface [polypeptide binding]; other site
323848005346	active site
323848005347	antiporter inner membrane protein; Provisional; Region: PRK11670
323848005348	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
323848005349	Walker A motif; other site
323848005350	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
323848005351	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
323848005352	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
323848005353	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
323848005354	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
323848005355	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
323848005356	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
323848005357	Walker A/P-loop; other site
323848005358	ATP binding site [chemical binding]; other site
323848005359	Q-loop/lid; other site
323848005360	ABC transporter signature motif; other site
323848005361	Walker B; other site
323848005362	D-loop; other site
323848005363	H-loop/switch region; other site
323848005364	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
323848005365	active site
323848005366	catalytic triad [active]
323848005367	oxyanion hole [active]
323848005368	switch loop; other site
323848005369	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323848005370	Ligand Binding Site [chemical binding]; other site
323848005371	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
323848005372	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
323848005373	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
323848005374	active site
323848005375	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
323848005376	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
323848005377	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
323848005378	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
323848005379	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
323848005380	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
323848005381	Domain of unknown function DUF140; Region: DUF140; cl00510
323848005382	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
323848005383	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
323848005384	Walker A/P-loop; other site
323848005385	ATP binding site [chemical binding]; other site
323848005386	Q-loop/lid; other site
323848005387	ABC transporter signature motif; other site
323848005388	Walker B; other site
323848005389	D-loop; other site
323848005390	H-loop/switch region; other site
323848005391	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
323848005392	mce related protein; Region: MCE; cl03606
323848005393	Protein of unknown function (DUF330); Region: DUF330; cl01135
323848005394	lipoyl synthase; Provisional; Region: PRK05481
323848005395	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
323848005396	FeS/SAM binding site; other site
323848005397	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
323848005398	Protein of unknown function (DUF493); Region: DUF493; cl01102
323848005399	branched-chain amino acid aminotransferase; Provisional; Region: PRK12479
323848005400	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558
323848005401	homodimer interface [polypeptide binding]; other site
323848005402	substrate-cofactor binding pocket; other site
323848005403	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848005404	catalytic residue [active]
323848005405	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
323848005406	Beta-lactamase; Region: Beta-lactamase; cl01009
323848005407	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
323848005408	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
323848005409	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848005410	CobD/Cbib protein; Region: CobD_Cbib; cl00561
323848005411	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
323848005412	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848005413	CoA-ligase; Region: Ligase_CoA; pfam00549
323848005414	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
323848005415	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848005416	CoA-ligase; Region: Ligase_CoA; pfam00549
323848005417	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
323848005418	Active site [active]
323848005419	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
323848005420	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
323848005421	Multicopper oxidase; Region: Cu-oxidase; cl14658
323848005422	Multicopper oxidase; Region: Cu-oxidase; cl14658
323848005423	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
323848005424	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848005425	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
323848005426	active site
323848005427	substrate binding site [chemical binding]; other site
323848005428	catalytic site [active]
323848005429	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
323848005430	GIY-YIG catalytic domain; Region: GIY-YIG; cl01061
323848005431	Staphylococcal nuclease homologues; Region: SNc; smart00318
323848005432	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
323848005433	Catalytic site; other site
323848005434	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
323848005435	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323848005436	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
323848005437	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
323848005438	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848005439	putative transposase OrfB; Reviewed; Region: PHA02517
323848005440	Integrase core domain; Region: rve; cl01316
323848005441	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848005442	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323848005443	Phage integrase family; Region: Phage_integrase; pfam00589
323848005444	DNA binding site [nucleotide binding]
323848005445	Int/Topo IB signature motif; other site
323848005446	active site
323848005447	Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448
323848005448	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
323848005449	dimer interface [polypeptide binding]; other site
323848005450	ligand binding site [chemical binding]; other site
323848005451	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848005452	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
323848005453	putative active site [active]
323848005454	heme pocket [chemical binding]; other site
323848005455	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
323848005456	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848005457	putative active site [active]
323848005458	heme pocket [chemical binding]; other site
323848005459	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
323848005460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848005461	ATP binding site [chemical binding]; other site
323848005462	Mg2+ binding site [ion binding]; other site
323848005463	G-X-G motif; other site
323848005464	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848005465	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323848005466	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848005467	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
323848005468	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848005469	PEP-CTERM motif; Region: VPEP; pfam07589
323848005470	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
323848005471	Integrase core domain; Region: rve; cl01316
323848005472	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848005473	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
323848005474	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
323848005475	DNA-binding interface [nucleotide binding]; DNA binding site
323848005476	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
323848005477	Integrase core domain; Region: rve; cl01316
323848005478	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848005479	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848005480	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848005481	Integrase core domain; Region: rve; cl01316
323848005482	PEP-CTERM motif; Region: VPEP; pfam07589
323848005483	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
323848005484	RelB antitoxin; Region: RelB; cl01171
323848005485	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
323848005486	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323848005487	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323848005488	ligand binding site [chemical binding]; other site
323848005489	flexible hinge region; other site
323848005490	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848005491	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848005492	active site
323848005493	phosphorylation site [posttranslational modification]
323848005494	intermolecular recognition site; other site
323848005495	dimerization interface [polypeptide binding]; other site
323848005496	PAS domain S-box; Region: sensory_box; TIGR00229
323848005497	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848005498	putative active site [active]
323848005499	heme pocket [chemical binding]; other site
323848005500	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848005501	metal binding site [ion binding]; metal-binding site
323848005502	active site
323848005503	I-site; other site
323848005504	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
323848005505	Domain of unknown function (DUF932); Region: DUF932; cl12129
323848005506	RES domain; Region: RES; cl02411
323848005507	Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966
323848005508	EamA-like transporter family; Region: EamA; cl01037
323848005509	putative transposase OrfB; Reviewed; Region: PHA02517
323848005510	Integrase core domain; Region: rve; cl01316
323848005511	putative transposase OrfB; Reviewed; Region: PHA02517
323848005512	Integrase core domain; Region: rve; cl01316
323848005513	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848005514	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
323848005515	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
323848005516	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
323848005517	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
323848005518	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323848005519	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
323848005520	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
323848005521	DNA binding residues [nucleotide binding]
323848005522	DNA primase; Validated; Region: dnaG; PRK05667
323848005523	CHC2 zinc finger; Region: zf-CHC2; cl02597
323848005524	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
323848005525	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
323848005526	active site
323848005527	metal binding site [ion binding]; metal-binding site
323848005528	interdomain interaction site; other site
323848005529	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
323848005530	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
323848005531	GatB domain; Region: GatB_Yqey; cl11497
323848005532	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
323848005533	putative glycoprotease GCP; Region: bact_gcp; TIGR03723
323848005534	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
323848005535	Domain of unknown function (DUF205); Region: DUF205; cl00410
323848005536	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534
323848005537	homooctamer interface [polypeptide binding]; other site
323848005538	active site
323848005539	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010
323848005540	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
323848005541	active site
323848005542	dimer interface [polypeptide binding]; other site
323848005543	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
323848005544	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
323848005545	IHF dimer interface [polypeptide binding]; other site
323848005546	IHF - DNA interface [nucleotide binding]; other site
323848005547	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
323848005548	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
323848005549	RNA binding site [nucleotide binding]; other site
323848005550	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
323848005551	RNA binding site [nucleotide binding]; other site
323848005552	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
323848005553	RNA binding site [nucleotide binding]; other site
323848005554	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689
323848005555	RNA binding site [nucleotide binding]; other site
323848005556	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690
323848005557	RNA binding site [nucleotide binding]; other site
323848005558	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691
323848005559	RNA binding site [nucleotide binding]; other site
323848005560	cytidylate kinase; Provisional; Region: cmk; PRK00023
323848005561	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
323848005562	CMP-binding site; other site
323848005563	The sites determining sugar specificity; other site
323848005564	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
323848005565	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556
323848005566	hinge; other site
323848005567	active site
323848005568	cysteine synthases; Region: cysKM; TIGR01136
323848005569	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
323848005570	dimer interface [polypeptide binding]; other site
323848005571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848005572	catalytic residue [active]
323848005573	serine O-acetyltransferase; Region: cysE; TIGR01172
323848005574	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354
323848005575	trimer interface [polypeptide binding]; other site
323848005576	active site
323848005577	substrate binding site [chemical binding]; other site
323848005578	CoA binding site [chemical binding]; other site
323848005579	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
323848005580	Sel1 repeat; Region: Sel1; cl02723
323848005581	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
323848005582	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848005583	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
323848005584	Copper resistance protein D; Region: CopD; cl00563
323848005585	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
323848005586	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
323848005587	Transglycosylase; Region: Transgly; cl07896
323848005588	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
323848005589	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
323848005590	dimer interface [polypeptide binding]; other site
323848005591	active site
323848005592	aspartate-rich active site metal binding site; other site
323848005593	allosteric magnesium binding site [ion binding]; other site
323848005594	Schiff base residues; other site
323848005595	The YihA (EngB) subfamily.  This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control.  YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876
323848005596	G1 box; other site
323848005597	GTP/Mg2+ binding site [chemical binding]; other site
323848005598	Switch I region; other site
323848005599	G2 box; other site
323848005600	G3 box; other site
323848005601	Switch II region; other site
323848005602	G4 box; other site
323848005603	G5 box; other site
323848005604	Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130
323848005605	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
323848005606	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848005607	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
323848005608	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
323848005609	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323848005610	active site
323848005611	HIGH motif; other site
323848005612	nucleotide binding site [chemical binding]; other site
323848005613	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
323848005614	KMSKS motif; other site
323848005615	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
323848005616	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
323848005617	catalytic residues [active]
323848005618	transcription termination factor Rho; Provisional; Region: rho; PRK09376
323848005619	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
323848005620	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459
323848005621	RNA binding site [nucleotide binding]; other site
323848005622	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128
323848005623	multimer interface [polypeptide binding]; other site
323848005624	Walker A motif; other site
323848005625	ATP binding site [chemical binding]; other site
323848005626	Walker B motif; other site
323848005627	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
323848005628	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
323848005629	active site
323848005630	metal binding site [ion binding]; metal-binding site
323848005631	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
323848005632	active site
323848005633	catalytic triad [active]
323848005634	oxyanion hole [active]
323848005635	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
323848005636	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
323848005637	active site
323848005638	catalytic site [active]
323848005639	metal binding site [ion binding]; metal-binding site
323848005640	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
323848005641	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
323848005642	Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677
323848005643	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
323848005644	dimer interface [polypeptide binding]; other site
323848005645	substrate binding site [chemical binding]; other site
323848005646	metal binding sites [ion binding]; metal-binding site
323848005647	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
323848005648	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
323848005649	putative active site [active]
323848005650	Integrase core domain; Region: rve; cl01316
323848005651	Found in ATP-dependent protease La (LON); Region: LON; cl01056
323848005652	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
323848005653	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848005654	Walker A motif; other site
323848005655	ATP binding site [chemical binding]; other site
323848005656	Walker B motif; other site
323848005657	arginine finger; other site
323848005658	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
323848005659	Integrase core domain; Region: rve; cl01316
323848005660	Cupin domain; Region: Cupin_2; cl09118
323848005661	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
323848005662	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
323848005663	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
323848005664	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
323848005665	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
323848005666	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
323848005667	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
323848005668	Outer membrane efflux protein; Region: OEP; pfam02321
323848005669	Outer membrane efflux protein; Region: OEP; pfam02321
323848005670	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
323848005671	heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914
323848005672	Protein of unknown function (DUF2863); Region: DUF2863; pfam11062
323848005673	SelR domain; Region: SelR; cl00369
323848005674	Intracellular septation protein A; Region: IspA; cl01098
323848005675	YCII-related domain; Region: YCII; cl00999
323848005676	BolA-like protein; Region: BolA; cl00386
323848005677	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
323848005678	PPIC-type PPIASE domain; Region: Rotamase; cl08278
323848005679	alanine racemase; Reviewed; Region: alr; PRK00053
323848005680	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
323848005681	active site
323848005682	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
323848005683	substrate binding site [chemical binding]; other site
323848005684	catalytic residues [active]
323848005685	dimer interface [polypeptide binding]; other site
323848005686	lysophospholipid transporter LplT; Provisional; Region: PRK11195
323848005687	Domain of unknown function (DUF477); Region: DUF477; cl01535
323848005688	Domain of unknown function (DUF477); Region: DUF477; cl01535
323848005689	LemA family; Region: LemA; cl00742
323848005690	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
323848005691	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
323848005692	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
323848005693	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
323848005694	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
323848005695	Coenzyme A binding pocket [chemical binding]; other site
323848005696	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
323848005697	Protein required for attachment to host cells; Region: Host_attach; cl02398
323848005698	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
323848005699	2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834
323848005700	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554
323848005701	homotrimer interaction site [polypeptide binding]; other site
323848005702	zinc binding site [ion binding]; other site
323848005703	CDP-binding sites; other site
323848005704	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
323848005705	substrate binding site [chemical binding]; other site
323848005706	dimer interface [polypeptide binding]; other site
323848005707	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
323848005708	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848005709	Walker A motif; other site
323848005710	ATP binding site [chemical binding]; other site
323848005711	Walker B motif; other site
323848005712	arginine finger; other site
323848005713	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
323848005714	Protein of unknown function (DUF1342); Region: DUF1342; cl01892
323848005715	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
323848005716	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
323848005717	CoA-binding site [chemical binding]; other site
323848005718	ATP-binding [chemical binding]; other site
323848005719	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
323848005720	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
323848005721	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
323848005722	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
323848005723	Domain of unknown function DUF21; Region: DUF21; pfam01595
323848005724	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
323848005725	Transporter associated domain; Region: CorC_HlyC; pfam03471
323848005726	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
323848005727	signal recognition particle protein; Provisional; Region: PRK10867
323848005728	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
323848005729	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
323848005730	P loop; other site
323848005731	GTP binding site [chemical binding]; other site
323848005732	Signal peptide binding domain; Region: SRP_SPB; pfam02978
323848005733	Uncharacterized ACR, COG1430; Region: DUF192; cl00627
323848005734	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
323848005735	trimer interface [polypeptide binding]; other site
323848005736	active site
323848005737	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
323848005738	Flavoprotein; Region: Flavoprotein; cl08021
323848005739	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
323848005740	hypothetical protein; Reviewed; Region: PRK00024
323848005741	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
323848005742	MPN+ (JAMM) motif; other site
323848005743	Zinc-binding site [ion binding]; other site
323848005744	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
323848005745	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
323848005746	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
323848005747	Di-iron ligands [ion binding]; other site
323848005748	Isochorismatase family; Region: Isochorismatase; pfam00857
323848005749	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
323848005750	catalytic triad [active]
323848005751	conserved cis-peptide bond; other site
323848005752	Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335
323848005753	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
323848005754	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
323848005755	putative NAD(P) binding site [chemical binding]; other site
323848005756	active site
323848005757	Protein of unknown function (DUF421); Region: DUF421; cl00990
323848005758	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
323848005759	active site
323848005760	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
323848005761	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
323848005762	NAD binding site [chemical binding]; other site
323848005763	catalytic Zn binding site [ion binding]; other site
323848005764	structural Zn binding site [ion binding]; other site
323848005765	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
323848005766	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323848005767	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
323848005768	putative homodimer interface [polypeptide binding]; other site
323848005769	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
323848005770	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848005771	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848005772	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
323848005773	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323848005774	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
323848005775	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
323848005776	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
323848005777	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
323848005778	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
323848005779	Tyrosinase co-factor MelC1; Region: MelC1; pfam06236
323848005780	RNA 3'-phosphate cyclase; Region: RNA_3prim_cycl; TIGR03399
323848005781	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in...; Region: RNA_Cyclase_Class_II; cd00874
323848005782	putative active site [active]
323848005783	adenylation catalytic residue [active]
323848005784	Protein of unknown function (DUF504); Region: DUF504; cl00661
323848005785	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
323848005786	Putative molybdenum carrier; Region: MoCo_carrier; pfam12694
323848005787	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
323848005788	catalytic nucleophile [active]
323848005789	cytochrome P450 83B1; Provisional; Region: PLN03234
323848005790	Cytochrome P450; Region: p450; cl12078
323848005791	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
323848005792	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
323848005793	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
323848005794	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
323848005795	active site
323848005796	Zn binding site [ion binding]; other site
323848005797	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
323848005798	dimer interface [polypeptide binding]; other site
323848005799	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848005800	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
323848005801	Integrase core domain; Region: rve; cl01316
323848005802	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
323848005803	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
323848005804	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
323848005805	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
323848005806	ATP binding site [chemical binding]; other site
323848005807	putative Mg++ binding site [ion binding]; other site
323848005808	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848005809	Domain of unknown function (DUF927); Region: DUF927; cl12098
323848005810	Domain of unknown function (DUF927); Region: DUF927; cl12098
323848005811	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
323848005812	integrase; Provisional; Region: PRK09692
323848005813	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
323848005814	active site
323848005815	Int/Topo IB signature motif; other site
323848005816	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
323848005817	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
323848005818	motif II; other site
323848005819	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
323848005820	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848005821	S-adenosylmethionine binding site [chemical binding]; other site
323848005822	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
323848005823	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
323848005824	active site
323848005825	putative substrate binding pocket [chemical binding]; other site
323848005826	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323848005827	ligand binding site [chemical binding]; other site
323848005828	DNA gyrase subunit A; Validated; Region: PRK05560
323848005829	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
323848005830	CAP-like domain; other site
323848005831	Active site [active]
323848005832	primary dimer interface [polypeptide binding]; other site
323848005833	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323848005834	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323848005835	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323848005836	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323848005837	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323848005838	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
323848005839	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active...; Region: PSAT_like; cd00611
323848005840	homodimer interface [polypeptide binding]; other site
323848005841	substrate-cofactor binding pocket; other site
323848005842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848005843	catalytic residue [active]
323848005844	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
323848005845	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848005846	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
323848005847	L-serine binding site [chemical binding]; other site
323848005848	ACT domain interface; other site
323848005849	Chorismate mutase type II; Region: CM_2; cl00693
323848005850	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
323848005851	Prephenate dehydratase; Region: PDT; pfam00800
323848005852	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
323848005853	putative L-Phe binding site [chemical binding]; other site
323848005854	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
323848005855	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323848005856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848005857	homodimer interface [polypeptide binding]; other site
323848005858	catalytic residue [active]
323848005859	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
323848005860	NeuB family; Region: NeuB; cl00496
323848005861	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
323848005862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848005863	Uncharacterized conserved protein [Function unknown]; Region: COG3461
323848005864	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
323848005865	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351
323848005866	active site
323848005867	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
323848005868	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220
323848005869	Walker A/P-loop; other site
323848005870	ATP binding site [chemical binding]; other site
323848005871	Q-loop/lid; other site
323848005872	ABC transporter signature motif; other site
323848005873	Walker B; other site
323848005874	D-loop; other site
323848005875	H-loop/switch region; other site
323848005876	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
323848005877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848005878	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
323848005879	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848005880	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
323848005881	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
323848005882	inhibitor-cofactor binding pocket; inhibition site
323848005883	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848005884	catalytic residue [active]
323848005885	Uncharacterized conserved protein [Function unknown]; Region: COG1432
323848005886	LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167
323848005887	putative metal binding site [ion binding]; other site
323848005888	LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7; Region: LOTUS; cl14879
323848005889	BON domain; Region: BON; cl02771
323848005890	BON domain; Region: BON; cl02771
323848005891	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848005892	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
323848005893	putative active site [active]
323848005894	heme pocket [chemical binding]; other site
323848005895	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
323848005896	sensor protein ZraS; Provisional; Region: PRK10364
323848005897	GAF domain; Region: GAF; cl00853
323848005898	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848005899	dimer interface [polypeptide binding]; other site
323848005900	phosphorylation site [posttranslational modification]
323848005901	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848005902	ATP binding site [chemical binding]; other site
323848005903	Mg2+ binding site [ion binding]; other site
323848005904	G-X-G motif; other site
323848005905	Response regulator receiver domain; Region: Response_reg; pfam00072
323848005906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848005907	active site
323848005908	phosphorylation site [posttranslational modification]
323848005909	intermolecular recognition site; other site
323848005910	dimerization interface [polypeptide binding]; other site
323848005911	Integrase core domain; Region: rve; cl01316
323848005912	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
323848005913	YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831
323848005914	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
323848005915	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
323848005916	YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831
323848005917	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
323848005918	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
323848005919	BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181
323848005920	TRAM domain; Region: TRAM; cl01282
323848005921	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
323848005922	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848005923	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
323848005924	active site
323848005925	catalytic site [active]
323848005926	substrate binding site [chemical binding]; other site
323848005927	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
323848005928	Protein of unknown function (DUF1318); Region: DUF1318; cl01547
323848005929	Dicarboxylate transport; Region: DctA-YdbH; cl14674
323848005930	cysteine synthases; Region: cysKM; TIGR01136
323848005931	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
323848005932	dimer interface [polypeptide binding]; other site
323848005933	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848005934	catalytic residue [active]
323848005935	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
323848005936	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
323848005937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848005938	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
323848005939	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
323848005940	dimer interface [polypeptide binding]; other site
323848005941	ssDNA binding site [nucleotide binding]; other site
323848005942	tetramer (dimer of dimers) interface [polypeptide binding]; other site
323848005943	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323848005944	Major Facilitator Superfamily; Region: MFS_1; pfam07690
323848005945	putative substrate translocation pore; other site
323848005946	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
323848005947	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
323848005948	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
323848005949	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
323848005950	MOFRL family; Region: MOFRL; cl01013
323848005951	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
323848005952	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848005953	active site
323848005954	phosphorylation site [posttranslational modification]
323848005955	intermolecular recognition site; other site
323848005956	dimerization interface [polypeptide binding]; other site
323848005957	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
323848005958	DNA binding site [nucleotide binding]
323848005959	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
323848005960	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
323848005961	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
323848005962	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848005963	dimer interface [polypeptide binding]; other site
323848005964	phosphorylation site [posttranslational modification]
323848005965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848005966	ATP binding site [chemical binding]; other site
323848005967	Mg2+ binding site [ion binding]; other site
323848005968	G-X-G motif; other site
323848005969	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
323848005970	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424
323848005971	dimer interface [polypeptide binding]; other site
323848005972	ADP-ribose binding site [chemical binding]; other site
323848005973	active site
323848005974	nudix motif; other site
323848005975	metal binding site [ion binding]; metal-binding site
323848005976	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
323848005977	Cu(I) binding site [ion binding]; other site
323848005978	Uncharacterized conserved protein [Function unknown]; Region: COG3391
323848005979	chaperone protein DnaJ; Provisional; Region: PRK10767
323848005980	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
323848005981	HSP70 interaction site [polypeptide binding]; other site
323848005982	DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908
323848005983	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
323848005984	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
323848005985	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
323848005986	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
323848005987	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446
323848005988	dimer interface [polypeptide binding]; other site
323848005989	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
323848005990	adenylosuccinate lyase; Provisional; Region: PRK09285
323848005991	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
323848005992	tetramer interface [polypeptide binding]; other site
323848005993	active site
323848005994	putative glutathione S-transferase; Provisional; Region: PRK10357
323848005995	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
323848005996	putative C-terminal domain interface [polypeptide binding]; other site
323848005997	putative GSH binding site (G-site) [chemical binding]; other site
323848005998	putative dimer interface [polypeptide binding]; other site
323848005999	GST_C family, unknown subfamily 6; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_6; cd03205
323848006000	putative N-terminal domain interface [polypeptide binding]; other site
323848006001	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
323848006002	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998
323848006003	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_2; cd03675
323848006004	nudix motif; other site
323848006005	isocitrate dehydrogenase; Validated; Region: PRK07362
323848006006	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
323848006007	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
323848006008	DNA-binding site [nucleotide binding]; DNA binding site
323848006009	RNA-binding motif; other site
323848006010	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
323848006011	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
323848006012	Clp amino terminal domain; Region: Clp_N; pfam02861
323848006013	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848006014	Walker A motif; other site
323848006015	ATP binding site [chemical binding]; other site
323848006016	Walker B motif; other site
323848006017	arginine finger; other site
323848006018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848006019	Walker A motif; other site
323848006020	ATP binding site [chemical binding]; other site
323848006021	Walker B motif; other site
323848006022	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
323848006023	Protein of unknown function (DUF1458); Region: DUF1458; cl01328
323848006024	cyanophycin synthetase; Provisional; Region: PRK14016
323848006025	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848006026	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323848006027	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323848006028	cyanophycin synthetase; Provisional; Region: PRK14016
323848006029	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848006030	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323848006031	Domain of unknown function (DUF1854); Region: DUF1854; pfam08909
323848006032	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
323848006033	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
323848006034	MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249
323848006035	Walker A/P-loop; other site
323848006036	ATP binding site [chemical binding]; other site
323848006037	Q-loop/lid; other site
323848006038	ABC transporter signature motif; other site
323848006039	Walker B; other site
323848006040	D-loop; other site
323848006041	H-loop/switch region; other site
323848006042	aspartate aminotransferase; Provisional; Region: PRK08361
323848006043	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
323848006044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848006045	homodimer interface [polypeptide binding]; other site
323848006046	catalytic residue [active]
323848006047	DinB superfamily; Region: DinB_2; cl00986
323848006048	TIGR03440 family protein; Region: unchr_TIGR03440
323848006049	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
323848006050	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848006051	S-adenosylmethionine binding site [chemical binding]; other site
323848006052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848006053	Outer membrane lipoprotein Slp family; Region: Slp; cl01164
323848006054	Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574
323848006055	TIR domain; Region: TIR; cl02060
323848006056	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
323848006057	homotrimer interaction site [polypeptide binding]; other site
323848006058	putative active site [active]
323848006059	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
323848006060	DNA binding residues [nucleotide binding]
323848006061	sucrose synthase; Region: sucr_synth; TIGR02470
323848006062	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
323848006063	putative ADP-binding pocket [chemical binding]; other site
323848006064	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
323848006065	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
323848006066	putative ADP-binding pocket [chemical binding]; other site
323848006067	sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471
323848006068	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
323848006069	putative substrate binding site [chemical binding]; other site
323848006070	putative ATP binding site [chemical binding]; other site
323848006071	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
323848006072	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848006073	S-adenosylmethionine binding site [chemical binding]; other site
323848006074	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848006075	Protein of unknown function (DUF971); Region: DUF971; cl01414
323848006076	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
323848006077	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
323848006078	substrate binding site [chemical binding]; other site
323848006079	catalytic Zn binding site [ion binding]; other site
323848006080	NAD binding site [chemical binding]; other site
323848006081	structural Zn binding site [ion binding]; other site
323848006082	dimer interface [polypeptide binding]; other site
323848006083	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
323848006084	Predicted esterase [General function prediction only]; Region: COG0627
323848006085	peptide chain release factor 2; Provisional; Region: PRK08787
323848006086	RF-1 domain; Region: RF-1; cl02875
323848006087	RF-1 domain; Region: RF-1; cl02875
323848006088	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
323848006089	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322
323848006090	dimer interface [polypeptide binding]; other site
323848006091	putative anticodon binding site; other site
323848006092	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
323848006093	motif 1; other site
323848006094	active site
323848006095	motif 2; other site
323848006096	motif 3; other site
323848006097	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
323848006098	metal-binding site [ion binding]
323848006099	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
323848006100	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
323848006101	metal-binding site [ion binding]
323848006102	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
323848006103	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
323848006104	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
323848006105	metal-binding site [ion binding]
323848006106	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
323848006107	putative homotetramer interface [polypeptide binding]; other site
323848006108	putative homodimer interface [polypeptide binding]; other site
323848006109	putative allosteric switch controlling residues; other site
323848006110	putative metal binding site [ion binding]; other site
323848006111	putative homodimer-homodimer interface [polypeptide binding]; other site
323848006112	Cytochrome c; Region: Cytochrom_C; cl11414
323848006113	Cytochrome c; Region: Cytochrom_C; cl11414
323848006114	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
323848006115	Cytochrome c; Region: Cytochrom_C; cl11414
323848006116	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
323848006117	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
323848006118	putative NADP binding site [chemical binding]; other site
323848006119	putative substrate binding site [chemical binding]; other site
323848006120	active site
323848006121	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
323848006122	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
323848006123	The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family also possess a conserved ATPase activity that...; Region: ABC_MutS_homologs; cd03243
323848006124	Walker A/P-loop; other site
323848006125	ATP binding site [chemical binding]; other site
323848006126	Q-loop/lid; other site
323848006127	ABC transporter signature motif; other site
323848006128	Walker B; other site
323848006129	D-loop; other site
323848006130	H-loop/switch region; other site
323848006131	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
323848006132	Outer membrane efflux protein; Region: OEP; pfam02321
323848006133	Outer membrane efflux protein; Region: OEP; pfam02321
323848006134	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848006135	S-adenosylmethionine binding site [chemical binding]; other site
323848006136	ThiC family; Region: ThiC; cl08031
323848006137	Bacitracin resistance protein BacA; Region: BacA; cl00858
323848006138	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
323848006139	active site residue [active]
323848006140	glutamine synthetase; Provisional; Region: glnA; PRK09469
323848006141	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
323848006142	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
323848006143	Sel1 repeat; Region: Sel1; cl02723
323848006144	Sel1 repeat; Region: Sel1; cl02723
323848006145	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
323848006146	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848006147	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
323848006148	RHS Repeat; Region: RHS_repeat; cl11982
323848006149	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
323848006150	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
323848006151	Beta-lactamase; Region: Beta-lactamase; cl01009
323848006152	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
323848006153	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323848006154	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848006155	active site
323848006156	phosphorylation site [posttranslational modification]
323848006157	intermolecular recognition site; other site
323848006158	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
323848006159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848006160	active site
323848006161	phosphorylation site [posttranslational modification]
323848006162	intermolecular recognition site; other site
323848006163	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848006164	PAS fold; Region: PAS_3; pfam08447
323848006165	putative active site [active]
323848006166	heme pocket [chemical binding]; other site
323848006167	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
323848006168	GAF domain; Region: GAF; cl00853
323848006169	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848006170	metal binding site [ion binding]; metal-binding site
323848006171	active site
323848006172	I-site; other site
323848006173	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
323848006174	Response regulator receiver domain; Region: Response_reg; pfam00072
323848006175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848006176	active site
323848006177	phosphorylation site [posttranslational modification]
323848006178	intermolecular recognition site; other site
323848006179	dimerization interface [polypeptide binding]; other site
323848006180	PAS domain S-box; Region: sensory_box; TIGR00229
323848006181	hypothetical protein; Provisional; Region: PRK13560
323848006182	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848006183	putative active site [active]
323848006184	heme pocket [chemical binding]; other site
323848006185	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323848006186	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
323848006187	dimer interface [polypeptide binding]; other site
323848006188	phosphorylation site [posttranslational modification]
323848006189	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848006190	ATP binding site [chemical binding]; other site
323848006191	Mg2+ binding site [ion binding]; other site
323848006192	G-X-G motif; other site
323848006193	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
323848006194	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323848006195	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
323848006196	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
323848006197	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
323848006198	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
323848006199	DEAD-like helicases superfamily; Region: DEXDc; smart00487
323848006200	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323848006201	ATP binding site [chemical binding]; other site
323848006202	putative Mg++ binding site [ion binding]; other site
323848006203	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323848006204	nucleotide binding region [chemical binding]; other site
323848006205	ATP-binding site [chemical binding]; other site
323848006206	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
323848006207	O-methyltransferase; Region: Methyltransf_2; pfam00891
323848006208	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848006209	NAD(P) binding site [chemical binding]; other site
323848006210	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
323848006211	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
323848006212	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
323848006213	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
323848006214	substrate binding pocket [chemical binding]; other site
323848006215	membrane-bound complex binding site; other site
323848006216	hinge residues; other site
323848006217	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
323848006218	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323848006219	catalytic residue [active]
323848006220	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
323848006221	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
323848006222	dimer interface [polypeptide binding]; other site
323848006223	decamer (pentamer of dimers) interface [polypeptide binding]; other site
323848006224	catalytic triad [active]
323848006225	siroheme synthase; Provisional; Region: cysG; PRK10637
323848006226	precorrin-2 dehydrogenase; Validated; Region: PRK06719
323848006227	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
323848006228	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
323848006229	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
323848006230	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
323848006231	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
323848006232	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
323848006233	active site
323848006234	putative substrate binding region [chemical binding]; other site
323848006235	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
323848006236	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
323848006237	active site
323848006238	HIGH motif; other site
323848006239	dimer interface [polypeptide binding]; other site
323848006240	KMSKS motif; other site
323848006241	ScpA/B protein; Region: ScpA_ScpB; cl00598
323848006242	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
323848006243	Copper resistance protein D; Region: CopD; cl00563
323848006244	Cytochrome c; Region: Cytochrom_C; cl11414
323848006245	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
323848006246	Copper resistance protein CopC; Region: CopC; cl01012
323848006247	Monooxygenase subunit B protein; Region: Monooxygenase_B; cl04718
323848006248	Ammonia monooxygenase; Region: AMO; cl03602
323848006249	Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; cl04829
323848006250	primosome assembly protein PriA; Validated; Region: PRK05580
323848006251	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
323848006252	ATP binding site [chemical binding]; other site
323848006253	putative Mg++ binding site [ion binding]; other site
323848006254	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323848006255	ATP-binding site [chemical binding]; other site
323848006256	argininosuccinate lyase; Provisional; Region: PRK00855
323848006257	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
323848006258	active sites [active]
323848006259	tetramer interface [polypeptide binding]; other site
323848006260	Phosphotransferase enzyme family; Region: APH; pfam01636
323848006261	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
323848006262	active site
323848006263	ATP binding site [chemical binding]; other site
323848006264	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
323848006265	substrate binding site [chemical binding]; other site
323848006266	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
323848006267	RF3 subfamily.  Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria.  Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169
323848006268	G1 box; other site
323848006269	putative GEF interaction site [polypeptide binding]; other site
323848006270	GTP/Mg2+ binding site [chemical binding]; other site
323848006271	Switch I region; other site
323848006272	G2 box; other site
323848006273	G3 box; other site
323848006274	Switch II region; other site
323848006275	G4 box; other site
323848006276	G5 box; other site
323848006277	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
323848006278	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
323848006279	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
323848006280	Walker A/P-loop; other site
323848006281	ATP binding site [chemical binding]; other site
323848006282	Q-loop/lid; other site
323848006283	ABC transporter signature motif; other site
323848006284	Walker B; other site
323848006285	D-loop; other site
323848006286	H-loop/switch region; other site
323848006287	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
323848006288	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
323848006289	Walker A/P-loop; other site
323848006290	ATP binding site [chemical binding]; other site
323848006291	Q-loop/lid; other site
323848006292	ABC transporter signature motif; other site
323848006293	Walker B; other site
323848006294	D-loop; other site
323848006295	H-loop/switch region; other site
323848006296	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
323848006297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
323848006298	dimer interface [polypeptide binding]; other site
323848006299	conserved gate region; other site
323848006300	putative PBP binding loops; other site
323848006301	ABC-ATPase subunit interface; other site
323848006302	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
323848006303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
323848006304	dimer interface [polypeptide binding]; other site
323848006305	conserved gate region; other site
323848006306	putative PBP binding loops; other site
323848006307	ABC-ATPase subunit interface; other site
323848006308	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
323848006309	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
323848006310	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
323848006311	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
323848006312	NAD binding site [chemical binding]; other site
323848006313	homotetramer interface [polypeptide binding]; other site
323848006314	homodimer interface [polypeptide binding]; other site
323848006315	substrate binding site [chemical binding]; other site
323848006316	active site
323848006317	periplasmic folding chaperone; Provisional; Region: PRK10788
323848006318	PPIC-type PPIASE domain; Region: Rotamase; cl08278
323848006319	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
323848006320	IHF dimer interface [polypeptide binding]; other site
323848006321	IHF - DNA interface [nucleotide binding]; other site
323848006322	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
323848006323	Found in ATP-dependent protease La (LON); Region: LON; cl01056
323848006324	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848006325	Walker A motif; other site
323848006326	ATP binding site [chemical binding]; other site
323848006327	Walker B motif; other site
323848006328	arginine finger; other site
323848006329	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
323848006330	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
323848006331	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
323848006332	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848006333	Walker A motif; other site
323848006334	ATP binding site [chemical binding]; other site
323848006335	Walker B motif; other site
323848006336	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
323848006337	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
323848006338	oligomer interface [polypeptide binding]; other site
323848006339	active site residues [active]
323848006340	trigger factor; Provisional; Region: tig; PRK01490
323848006341	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
323848006342	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
323848006343	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848006344	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
323848006345	NAD(P) binding site [chemical binding]; other site
323848006346	active site
323848006347	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
323848006348	active site lid residues [active]
323848006349	substrate binding pocket [chemical binding]; other site
323848006350	catalytic residues [active]
323848006351	substrate-Mg2+ binding site; other site
323848006352	aspartate-rich region 1; other site
323848006353	aspartate-rich region 2; other site
323848006354	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
323848006355	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
323848006356	ring oligomerisation interface [polypeptide binding]; other site
323848006357	ATP/Mg binding site [chemical binding]; other site
323848006358	stacking interactions; other site
323848006359	hinge regions; other site
323848006360	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320
323848006361	oligomerisation interface [polypeptide binding]; other site
323848006362	mobile loop; other site
323848006363	roof hairpin; other site
323848006364	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848006365	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848006366	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
323848006367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848006368	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
323848006369	Walker A motif; other site
323848006370	ATP binding site [chemical binding]; other site
323848006371	Walker B motif; other site
323848006372	arginine finger; other site
323848006373	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848006374	binding surface
323848006375	TPR motif; other site
323848006376	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
323848006377	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
323848006378	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
323848006379	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130
323848006380	ATP binding site [chemical binding]; other site
323848006381	Walker A motif; other site
323848006382	hexamer interface [polypeptide binding]; other site
323848006383	Walker B motif; other site
323848006384	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
323848006385	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111
323848006386	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111
323848006387	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
323848006388	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
323848006389	SAF domain; Region: SAF; cl00555
323848006390	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
323848006391	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
323848006392	inhibitor-cofactor binding pocket; inhibition site
323848006393	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848006394	catalytic residue [active]
323848006395	Beta-lactamase; Region: Beta-lactamase; cl01009
323848006396	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085
323848006397	active site
323848006398	anthranilate synthase component I; Provisional; Region: PRK13565
323848006399	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
323848006400	chorismate binding enzyme; Region: Chorismate_bind; cl10555
323848006401	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
323848006402	motif II; other site
323848006403	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
323848006404	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
323848006405	substrate binding site [chemical binding]; other site
323848006406	hexamer interface [polypeptide binding]; other site
323848006407	metal binding site [ion binding]; metal-binding site
323848006408	Protein of unknown function (DUF525); Region: DUF525; cl01119
323848006409	GTP-binding protein Der; Reviewed; Region: PRK00093
323848006410	EngA1 subfamily.  This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894
323848006411	G1 box; other site
323848006412	GTP/Mg2+ binding site [chemical binding]; other site
323848006413	Switch I region; other site
323848006414	G2 box; other site
323848006415	Switch II region; other site
323848006416	G3 box; other site
323848006417	G4 box; other site
323848006418	G5 box; other site
323848006419	EngA2 subfamily.  This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895
323848006420	G1 box; other site
323848006421	GTP/Mg2+ binding site [chemical binding]; other site
323848006422	Switch I region; other site
323848006423	G2 box; other site
323848006424	G3 box; other site
323848006425	Switch II region; other site
323848006426	G4 box; other site
323848006427	G5 box; other site
323848006428	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
323848006429	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
323848006430	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
323848006431	active site
323848006432	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
323848006433	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
323848006434	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
323848006435	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
323848006436	dimer interface [polypeptide binding]; other site
323848006437	motif 1; other site
323848006438	active site
323848006439	motif 2; other site
323848006440	motif 3; other site
323848006441	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
323848006442	anticodon binding site; other site
323848006443	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
323848006444	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
323848006445	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
323848006446	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
323848006447	cytoskeletal protein RodZ; Provisional; Region: PRK10856
323848006448	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
323848006449	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
323848006450	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
323848006451	active site
323848006452	multimer interface [polypeptide binding]; other site
323848006453	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
323848006454	Zn binding site [ion binding]; other site
323848006455	Protein of unknown function, DUF399; Region: DUF399; cl01139
323848006456	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
323848006457	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
323848006458	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203
323848006459	dimerization interface [polypeptide binding]; other site
323848006460	ATP binding site [chemical binding]; other site
323848006461	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204
323848006462	dimerization interface [polypeptide binding]; other site
323848006463	ATP binding site [chemical binding]; other site
323848006464	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
323848006465	putative active site [active]
323848006466	catalytic triad [active]
323848006467	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
323848006468	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
323848006469	putative substrate binding site [chemical binding]; other site
323848006470	putative ATP binding site [chemical binding]; other site
323848006471	Response regulator receiver domain; Region: Response_reg; pfam00072
323848006472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848006473	active site
323848006474	phosphorylation site [posttranslational modification]
323848006475	intermolecular recognition site; other site
323848006476	dimerization interface [polypeptide binding]; other site
323848006477	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
323848006478	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
323848006479	ligand binding site [chemical binding]; other site
323848006480	flexible hinge region; other site
323848006481	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848006482	peroxidase; Provisional; Region: PRK15000
323848006483	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015
323848006484	dimer interface [polypeptide binding]; other site
323848006485	decamer (pentamer of dimers) interface [polypeptide binding]; other site
323848006486	catalytic triad [active]
323848006487	peroxidatic and resolving cysteines [active]
323848006488	Ferritin-like domain; Region: Ferritin; pfam00210
323848006489	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
323848006490	dinuclear metal binding motif [ion binding]; other site
323848006491	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
323848006492	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
323848006493	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323848006494	N-terminal plug; other site
323848006495	ligand-binding site [chemical binding]; other site
323848006496	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
323848006497	Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670
323848006498	Multicopper oxidase; Region: Cu-oxidase; cl14658
323848006499	Multicopper oxidase; Region: Cu-oxidase; cl14658
323848006500	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
323848006501	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
323848006502	Ferritin-like domain; Region: Ferritin; pfam00210
323848006503	heme binding site [chemical binding]; other site
323848006504	ferroxidase pore; other site
323848006505	ferroxidase diiron center [ion binding]; other site
323848006506	ABC-2 type transporter; Region: ABC2_membrane; cl11417
323848006507	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
323848006508	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220
323848006509	Walker A/P-loop; other site
323848006510	ATP binding site [chemical binding]; other site
323848006511	Q-loop/lid; other site
323848006512	ABC transporter signature motif; other site
323848006513	Walker B; other site
323848006514	D-loop; other site
323848006515	H-loop/switch region; other site
323848006516	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848006517	S-adenosylmethionine binding site [chemical binding]; other site
323848006518	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
323848006519	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
323848006520	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
323848006521	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
323848006522	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848006523	S-adenosylmethionine binding site [chemical binding]; other site
323848006524	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
323848006525	Probable Catalytic site [active]
323848006526	metal binding site [ion binding]; metal-binding site
323848006527	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
323848006528	Rhamnan synthesis protein F; Region: RgpF; cl01529
323848006529	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
323848006530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848006531	NAD(P) binding site [chemical binding]; other site
323848006532	active site
323848006533	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
323848006534	Integrase core domain; Region: rve; cl01316
323848006535	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848006536	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
323848006537	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323848006538	active site
323848006539	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
323848006540	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848006541	NAD(P) binding site [chemical binding]; other site
323848006542	active site
323848006543	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848006544	RF-1 domain; Region: RF-1; cl02875
323848006545	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
323848006546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848006547	ATP binding site [chemical binding]; other site
323848006548	Mg2+ binding site [ion binding]; other site
323848006549	G-X-G motif; other site
323848006550	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848006551	active site
323848006552	phosphorylation site [posttranslational modification]
323848006553	intermolecular recognition site; other site
323848006554	dimerization interface [polypeptide binding]; other site
323848006555	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
323848006556	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
323848006557	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
323848006558	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
323848006559	Protein of unknown function (DUF615); Region: DUF615; cl01147
323848006560	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
323848006561	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
323848006562	Sulfatase; Region: Sulfatase; cl10460
323848006563	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
323848006564	Autoinducer binding domain; Region: Autoind_bind; pfam03472
323848006565	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
323848006566	DNA binding residues [nucleotide binding]
323848006567	dimerization interface [polypeptide binding]; other site
323848006568	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
323848006569	putative phosphate binding site [ion binding]; other site
323848006570	putative catalytic site [active]
323848006571	active site
323848006572	metal binding site A [ion binding]; metal-binding site
323848006573	DNA binding site [nucleotide binding]
323848006574	putative AP binding site [nucleotide binding]; other site
323848006575	putative metal binding site B [ion binding]; other site
323848006576	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
323848006577	GTP cyclohydrolase I; Provisional; Region: PLN03044
323848006578	active site
323848006579	recombination and repair protein; Provisional; Region: PRK10869
323848006580	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
323848006581	Walker A/P-loop; other site
323848006582	ATP binding site [chemical binding]; other site
323848006583	Q-loop/lid; other site
323848006584	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
323848006585	ABC transporter signature motif; other site
323848006586	Walker B; other site
323848006587	D-loop; other site
323848006588	H-loop/switch region; other site
323848006589	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
323848006590	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
323848006591	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
323848006592	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848006593	HrcA protein C terminal domain; Region: HrcA; pfam01628
323848006594	ferrochelatase; Reviewed; Region: hemH; PRK00035
323848006595	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
323848006596	C-terminal domain interface [polypeptide binding]; other site
323848006597	active site
323848006598	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
323848006599	active site
323848006600	N-terminal domain interface [polypeptide binding]; other site
323848006601	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
323848006602	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
323848006603	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
323848006604	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
323848006605	Protein export membrane protein; Region: SecD_SecF; cl14618
323848006606	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
323848006607	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
323848006608	Protein export membrane protein; Region: SecD_SecF; cl14618
323848006609	Preprotein translocase subunit; Region: YajC; cl00806
323848006610	Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
323848006611	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
323848006612	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
323848006613	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
323848006614	TM1410 hypothetical-related protein; Region: DUF297; cl00997
323848006615	Predicted membrane protein [Function unknown]; Region: COG4267
323848006616	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_3; cd03813
323848006617	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
323848006618	TM1410 hypothetical-related protein; Region: DUF297; cl00997
323848006619	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
323848006620	ChaB; Region: ChaB; cl01887
323848006621	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848006622	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
323848006623	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020
323848006624	dimerization domain [polypeptide binding]; other site
323848006625	dimer interface [polypeptide binding]; other site
323848006626	catalytic residues [active]
323848006627	MltA specific insert domain; Region: MltA; pfam03562
323848006628	3D domain; Region: 3D; cl01439
323848006629	glutamate dehydrogenase; Provisional; Region: PRK09414
323848006630	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
323848006631	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
323848006632	NAD(P) binding site [chemical binding]; other site
323848006633	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
323848006634	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
323848006635	NAD(P) binding site [chemical binding]; other site
323848006636	catalytic residues [active]
323848006637	lytic murein transglycosylase; Provisional; Region: PRK11619
323848006638	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
323848006639	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
323848006640	N-acetyl-D-glucosamine binding site [chemical binding]; other site
323848006641	catalytic residue [active]
323848006642	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
323848006643	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
323848006644	putative NAD(P) binding site [chemical binding]; other site
323848006645	active site
323848006646	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
323848006647	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
323848006648	active site
323848006649	NTP binding site [chemical binding]; other site
323848006650	metal binding triad [ion binding]; metal-binding site
323848006651	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
323848006652	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
323848006653	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
323848006654	short chain dehydrogenase; Provisional; Region: PRK06181
323848006655	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
323848006656	NAD(P) binding site [chemical binding]; other site
323848006657	active site
323848006658	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
323848006659	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
323848006660	catalytic residues [active]
323848006661	hinge region; other site
323848006662	alpha helical domain; other site
323848006663	Sporulation related domain; Region: SPOR; cl10051
323848006664	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
323848006665	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
323848006666	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
323848006667	active site
323848006668	HIGH motif; other site
323848006669	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
323848006670	KMSK motif region; other site
323848006671	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
323848006672	tRNA binding surface [nucleotide binding]; other site
323848006673	anticodon binding site; other site
323848006674	Uncharacterized conserved protein [Function unknown]; Region: COG5634
323848006675	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848006676	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848006677	Uncharacterized conserved protein [Function unknown]; Region: COG5634
323848006678	TIGR03790 family protein; Region: TIGR03790
323848006679	Rhomboid family; Region: Rhomboid; cl11446
323848006680	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
323848006681	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
323848006682	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
323848006683	ParB-like partition proteins; Region: parB_part; TIGR00180
323848006684	ParB-like nuclease domain; Region: ParBc; cl02129
323848006685	Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; cl04829
323848006686	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
323848006687	ATP cone domain; Region: ATP-cone; pfam03477
323848006688	ATP cone domain; Region: ATP-cone; pfam03477
323848006689	Class I ribonucleotide reductase; Region: RNR_I; cd01679
323848006690	active site
323848006691	dimer interface [polypeptide binding]; other site
323848006692	catalytic residues [active]
323848006693	effector binding site; other site
323848006694	R2 peptide binding site; other site
323848006695	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
323848006696	dimer interface [polypeptide binding]; other site
323848006697	putative radical transfer pathway; other site
323848006698	diiron center [ion binding]; other site
323848006699	tyrosyl radical; other site
323848006700	fumarate hydratase; Reviewed; Region: fumC; PRK00485
323848006701	Class II fumarases; Region: Fumarase_classII; cd01362
323848006702	active site
323848006703	tetramer interface [polypeptide binding]; other site
323848006704	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
323848006705	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
323848006706	active site
323848006707	nucleophile elbow; other site
323848006708	Integral membrane protein TerC family; Region: TerC; cl10468
323848006709	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
323848006710	Ligand Binding Site [chemical binding]; other site
323848006711	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
323848006712	Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
323848006713	Pilin (bacterial filament); Region: Pilin; pfam00114
323848006714	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
323848006715	Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525
323848006716	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
323848006717	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
323848006718	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
323848006719	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
323848006720	dihydroorotase; Provisional; Region: PRK07627
323848006721	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
323848006722	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317
323848006723	active site
323848006724	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
323848006725	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
323848006726	active site
323848006727	Zn binding site [ion binding]; other site
323848006728	murein transglycosylase A; Provisional; Region: mltA; PRK11162
323848006729	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
323848006730	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
323848006731	hypothetical protein; Provisional; Region: PRK10396
323848006732	SEC-C motif; Region: SEC-C; cl12132
323848006733	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
323848006734	Peptidase family M23; Region: Peptidase_M23; pfam01551
323848006735	Protein of unknown function (DUF721); Region: DUF721; cl02324
323848006736	cell division protein FtsZ; Validated; Region: PRK09330
323848006737	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201
323848006738	nucleotide binding site [chemical binding]; other site
323848006739	SulA interaction site; other site
323848006740	cell division protein FtsA; Region: ftsA; TIGR01174
323848006741	Cell division protein FtsA; Region: FtsA; cl11496
323848006742	Cell division protein FtsA; Region: FtsA; cl11496
323848006743	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
323848006744	Cell division protein FtsQ; Region: FtsQ; pfam03799
323848006745	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
323848006746	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
323848006747	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848006748	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
323848006749	FAD binding domain; Region: FAD_binding_4; pfam01565
323848006750	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
323848006751	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
323848006752	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
323848006753	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323848006754	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323848006755	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
323848006756	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785
323848006757	active site
323848006758	homodimer interface [polypeptide binding]; other site
323848006759	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
323848006760	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
323848006761	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323848006762	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323848006763	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
323848006764	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852
323848006765	Mg++ binding site [ion binding]; other site
323848006766	putative catalytic motif [active]
323848006767	putative substrate binding site [chemical binding]; other site
323848006768	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
323848006769	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
323848006770	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323848006771	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323848006772	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
323848006773	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
323848006774	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
323848006775	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
323848006776	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
323848006777	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
323848006778	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
323848006779	Septum formation initiator; Region: DivIC; cl11433
323848006780	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
323848006781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848006782	cell division protein MraZ; Reviewed; Region: PRK00326
323848006783	MraZ protein; Region: MraZ; pfam02381
323848006784	MraZ protein; Region: MraZ; pfam02381
323848006785	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
323848006786	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
323848006787	synthetase active site [active]
323848006788	NTP binding site [chemical binding]; other site
323848006789	metal binding site [ion binding]; metal-binding site
323848006790	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
323848006791	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
323848006792	Competence protein; Region: Competence; cl00471
323848006793	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
323848006794	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
323848006795	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
323848006796	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
323848006797	Walker A/P-loop; other site
323848006798	ATP binding site [chemical binding]; other site
323848006799	Q-loop/lid; other site
323848006800	ABC transporter signature motif; other site
323848006801	Walker B; other site
323848006802	D-loop; other site
323848006803	H-loop/switch region; other site
323848006804	LolC/E family; Region: lolCE; TIGR02212
323848006805	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
323848006806	FtsX-like permease family; Region: FtsX; pfam02687
323848006807	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
323848006808	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
323848006809	N-terminal plug; other site
323848006810	ligand-binding site [chemical binding]; other site
323848006811	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848006812	metal binding site 2 [ion binding]; metal-binding site
323848006813	putative DNA binding helix; other site
323848006814	metal binding site 1 [ion binding]; metal-binding site
323848006815	dimer interface [polypeptide binding]; other site
323848006816	structural Zn2+ binding site [ion binding]; other site
323848006817	VanZ like family; Region: VanZ; cl01971
323848006818	FkbH-like domain; Region: FkbH; TIGR01686
323848006819	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
323848006820	active site
323848006821	motif I; other site
323848006822	motif II; other site
323848006823	Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711
323848006824	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
323848006825	exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
323848006826	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
323848006827	active site
323848006828	dimer interface [polypeptide binding]; other site
323848006829	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes...; Region: Asn_Synthase_B_C; cd01991
323848006830	Ligand Binding Site [chemical binding]; other site
323848006831	Molecular Tunnel; other site
323848006832	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
323848006833	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
323848006834	putative ADP-binding pocket [chemical binding]; other site
323848006835	eight transmembrane protein EpsH (proposed exosortase); Region: 8TM_EpsH; cl10495
323848006836	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
323848006837	Protein of unknown function (DUF3485); Region: DUF3485; cl11827
323848006838	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
323848006839	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
323848006840	FemAB family; Region: FemAB; cl11444
323848006841	polysaccharide deactylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
323848006842	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
323848006843	Domain of unknown function (DUF3473); Region: DUF3473; pfam11959
323848006844	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848006845	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
323848006846	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051
323848006847	exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
323848006848	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
323848006849	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
323848006850	Chain length determinant protein; Region: Wzz; cl01623
323848006851	Chain length determinant protein; Region: Wzz; cl01623
323848006852	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
323848006853	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
323848006854	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
323848006855	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
323848006856	Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520
323848006857	Localisation of periplasmic protein complexes; Region: AMIN; pfam11741
323848006858	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
323848006859	active site
323848006860	metal binding site [ion binding]; metal-binding site
323848006861	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
323848006862	nudix motif; other site
323848006863	FemAB family; Region: FemAB; cl11444
323848006864	Protein of unknown function, DUF482; Region: DUF482; pfam04339
323848006865	NAD synthetase; Provisional; Region: PRK13981
323848006866	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
323848006867	multimer interface [polypeptide binding]; other site
323848006868	active site
323848006869	catalytic triad [active]
323848006870	protein interface 1 [polypeptide binding]; other site
323848006871	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553
323848006872	homodimer interface [polypeptide binding]; other site
323848006873	NAD binding pocket [chemical binding]; other site
323848006874	ATP binding pocket [chemical binding]; other site
323848006875	Mg binding site [ion binding]; other site
323848006876	active-site loop [active]
323848006877	Nitrogen regulatory protein P-II; Region: P-II; cl00412
323848006878	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
323848006879	Peptidase family M48; Region: Peptidase_M48; cl12018
323848006880	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848006881	TPR motif; other site
323848006882	binding surface
323848006883	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451
323848006884	homodimer interface [polypeptide binding]; other site
323848006885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848006886	catalytic residue [active]
323848006887	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
323848006888	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537
323848006889	FAD binding site [chemical binding]; other site
323848006890	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
323848006891	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401
323848006892	oligomerization interface [polypeptide binding]; other site
323848006893	active site
323848006894	NAD+ binding site [chemical binding]; other site
323848006895	S-adenosylmethionine synthetase; Validated; Region: PRK05250
323848006896	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
323848006897	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
323848006898	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
323848006899	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
323848006900	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
323848006901	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
323848006902	Protein of unknown function, DUF484; Region: DUF484; cl01228
323848006903	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323848006904	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
323848006905	DNA binding site [nucleotide binding]
323848006906	Int/Topo IB signature motif; other site
323848006907	active site
323848006908	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
323848006909	active site
323848006910	HslU subunit interaction site [polypeptide binding]; other site
323848006911	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
323848006912	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848006913	Walker A motif; other site
323848006914	ATP binding site [chemical binding]; other site
323848006915	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848006916	Predicted flavoproteins [General function prediction only]; Region: COG2081
323848006917	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
323848006918	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848006919	S-adenosylmethionine binding site [chemical binding]; other site
323848006920	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
323848006921	hypothetical protein; Provisional; Region: PRK05409
323848006922	Protein of unknown function (DUF692); Region: DUF692; cl01263
323848006923	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
323848006924	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
323848006925	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
323848006926	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
323848006927	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
323848006928	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
323848006929	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
323848006930	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
323848006931	putative nucleic acid binding region [nucleotide binding]; other site
323848006932	G-X-X-G motif; other site
323848006933	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472
323848006934	RNA binding site [nucleotide binding]; other site
323848006935	domain interface; other site
323848006936	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353
323848006937	16S/18S rRNA binding site [nucleotide binding]; other site
323848006938	S13e-L30e interaction site [polypeptide binding]; other site
323848006939	25S rRNA binding site [nucleotide binding]; other site
323848006940	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
323848006941	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
323848006942	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
323848006943	Active site cavity [active]
323848006944	catalytic acid [active]
323848006945	VacJ like lipoprotein; Region: VacJ; cl01073
323848006946	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
323848006947	ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074
323848006948	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
323848006949	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
323848006950	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
323848006951	FeS/SAM binding site; other site
323848006952	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
323848006953	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342
323848006954	trimer interface [polypeptide binding]; other site
323848006955	eyelet of channel; other site
323848006956	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
323848006957	active site
323848006958	ribulose/triose binding site [chemical binding]; other site
323848006959	phosphate binding site [ion binding]; other site
323848006960	substrate (anthranilate) binding pocket [chemical binding]; other site
323848006961	product (indole) binding pocket [chemical binding]; other site
323848006962	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
323848006963	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
323848006964	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
323848006965	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
323848006966	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
323848006967	glutamine binding [chemical binding]; other site
323848006968	catalytic triad [active]
323848006969	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
323848006970	Gram-negative bacterial tonB protein; Region: TonB; cl10048
323848006971	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
323848006972	Domain of unknown function (DUF2341); Region: DUF2341; pfam10102
323848006973	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102
323848006974	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323848006975	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
323848006976	Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560
323848006977	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
323848006978	putative active site [active]
323848006979	catalytic site [active]
323848006980	putative metal binding site [ion binding]; other site
323848006981	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
323848006982	haemagglutination activity domain; Region: Haemagg_act; cl05436
323848006983	Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545
323848006984	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
323848006985	chloroplast envelope protein translocase, IAP75 family; Region: 3a0901s03IAP75; TIGR00992
323848006986	Surface antigen; Region: Bac_surface_Ag; cl03097
323848006987	transcriptional regulator EpsA; Region: EpsA; TIGR03020
323848006988	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
323848006989	DNA binding residues [nucleotide binding]
323848006990	dimerization interface [polypeptide binding]; other site
323848006991	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
323848006992	Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334
323848006993	Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334
323848006994	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
323848006995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848006996	TPR motif; other site
323848006997	binding surface
323848006998	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
323848006999	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
323848007000	dockerin binding interface; other site
323848007001	GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
323848007002	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
323848007003	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
323848007004	Walker A motif; other site
323848007005	ATP binding site [chemical binding]; other site
323848007006	Walker B motif; other site
323848007007	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
323848007008	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
323848007009	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
323848007010	general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710
323848007011	Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
323848007012	Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334
323848007013	VanZ like family; Region: VanZ; cl01971
323848007014	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
323848007015	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
323848007016	Catalytic site [active]
323848007017	Cell division inhibitor SulA; Region: SulA; cl01880
323848007018	DNA Polymerase Y-family; Region: PolY_like; cd03468
323848007019	active site
323848007020	DNA binding site [nucleotide binding]
323848007021	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
323848007022	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
323848007023	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
323848007024	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485
323848007025	generic binding surface II; other site
323848007026	generic binding surface I; other site
323848007027	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
323848007028	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
323848007029	AIPR protein; Region: AIPR; pfam10592
323848007030	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848007031	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848007032	MT-A70; Region: MT-A70; cl01947
323848007033	Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195
323848007034	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
323848007035	UbiA prenyltransferase family; Region: UbiA; cl00337
323848007036	Chorismate lyase; Region: Chor_lyase; cl01230
323848007037	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
323848007038	gating phenylalanine in ion channel; other site
323848007039	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
323848007040	ABC-ATPase subunit  interface; other site
323848007041	dimer interface [polypeptide binding]; other site
323848007042	putative PBP binding regions; other site
323848007043	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
323848007044	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848007045	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
323848007046	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196
323848007047	dimerization interface [polypeptide binding]; other site
323848007048	putative ATP binding site [chemical binding]; other site
323848007049	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
323848007050	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
323848007051	active site
323848007052	substrate binding site [chemical binding]; other site
323848007053	cosubstrate binding site; other site
323848007054	catalytic site [active]
323848007055	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
323848007056	16S rRNA methyltransferase B; Provisional; Region: PRK14902
323848007057	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848007058	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
323848007059	putative active site [active]
323848007060	catalytic site [active]
323848007061	Mechanosensitive ion channel; Region: MS_channel; pfam00924
323848007062	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
323848007063	dimer interface [polypeptide binding]; other site
323848007064	active site
323848007065	metal binding site [ion binding]; metal-binding site
323848007066	glutathione binding site [chemical binding]; other site
323848007067	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730
323848007068	Rubredoxin; Region: Rubredoxin; pfam00301
323848007069	iron binding site [ion binding]; other site
323848007070	bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427
323848007071	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
323848007072	dimer interface [polypeptide binding]; other site
323848007073	substrate binding site [chemical binding]; other site
323848007074	ATP binding site [chemical binding]; other site
323848007075	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564
323848007076	thiamine phosphate binding site [chemical binding]; other site
323848007077	active site
323848007078	pyrophosphate binding site [ion binding]; other site
323848007079	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
323848007080	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
323848007081	inhibitor-cofactor binding pocket; inhibition site
323848007082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
323848007083	catalytic residue [active]
323848007084	Cytochrome c; Region: Cytochrom_C; cl11414
323848007085	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
323848007086	Cytochrome c; Region: Cytochrom_C; cl11414
323848007087	methionine aminopeptidase; Reviewed; Region: PRK07281
323848007088	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
323848007089	active site
323848007090	PII uridylyl-transferase; Provisional; Region: PRK03059
323848007091	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
323848007092	metal binding triad; other site
323848007093	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
323848007094	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
323848007095	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
323848007096	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
323848007097	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
323848007098	N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312
323848007099	THF binding site; other site
323848007100	C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311
323848007101	substrate binding site [chemical binding]; other site
323848007102	THF binding site; other site
323848007103	zinc-binding site [ion binding]; other site
323848007104	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
323848007105	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
323848007106	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
323848007107	putative dimerization interface [polypeptide binding]; other site
323848007108	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
323848007109	threonine and homoserine efflux system; Provisional; Region: PRK10532
323848007110	EamA-like transporter family; Region: EamA; cl01037
323848007111	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
323848007112	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
323848007113	putative GSH binding site [chemical binding]; other site
323848007114	catalytic residues [active]
323848007115	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
323848007116	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848007117	S-adenosylmethionine binding site [chemical binding]; other site
323848007118	peptide chain release factor 1; Validated; Region: prfA; PRK00591
323848007119	RF-1 domain; Region: RF-1; cl02875
323848007120	RF-1 domain; Region: RF-1; cl02875
323848007121	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
323848007122	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
323848007123	tRNA; other site
323848007124	putative tRNA binding site [nucleotide binding]; other site
323848007125	putative NADP binding site [chemical binding]; other site
323848007126	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
323848007127	Domain of unknown function DUF20; Region: UPF0118; cl00465
323848007128	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662
323848007129	nudix motif; other site
323848007130	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848007131	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
323848007132	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848007133	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
323848007134	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848007135	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
323848007136	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848007137	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848007138	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
323848007139	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
323848007140	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
323848007141	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
323848007142	active site
323848007143	Riboflavin kinase; Region: Flavokinase; pfam01687
323848007144	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
323848007145	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
323848007146	active site
323848007147	HIGH motif; other site
323848007148	nucleotide binding site [chemical binding]; other site
323848007149	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
323848007150	active site
323848007151	KMSKS motif; other site
323848007152	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
323848007153	tRNA binding surface [nucleotide binding]; other site
323848007154	anticodon binding site; other site
323848007155	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
323848007156	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
323848007157	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
323848007158	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
323848007159	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
323848007160	ATP binding site [chemical binding]; other site
323848007161	Mg++ binding site [ion binding]; other site
323848007162	motif III; other site
323848007163	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
323848007164	nucleotide binding region [chemical binding]; other site
323848007165	ATP-binding site [chemical binding]; other site
323848007166	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485
323848007167	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
323848007168	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
323848007169	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
323848007170	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
323848007171	Cu(I) binding site [ion binding]; other site
323848007172	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275
323848007173	Low-spin heme binding site [chemical binding]; other site
323848007174	D-pathway; other site
323848007175	Putative water exit pathway; other site
323848007176	Binuclear center (active site) [active]
323848007177	K-pathway; other site
323848007178	Putative proton exit pathway; other site
323848007179	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
323848007180	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
323848007181	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
323848007182	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes...; Region: Asn_Synthase_B_C; cd01991
323848007183	Ligand Binding Site [chemical binding]; other site
323848007184	Molecular Tunnel; other site
323848007185	pyridoxal-dependent decarboxylase, exosortase system type 1 associated; Region: dCO2ase_PEP1; TIGR03099
323848007186	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
323848007187	dimer interface [polypeptide binding]; other site
323848007188	active site
323848007189	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
323848007190	catalytic residues [active]
323848007191	substrate binding site [chemical binding]; other site
323848007192	acyl-CoA ligase (AMP-forming), exosortase system type 1 associated; Region: ligase_PEP_1; TIGR03098
323848007193	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
323848007194	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
323848007195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848007196	active site
323848007197	phosphorylation site [posttranslational modification]
323848007198	intermolecular recognition site; other site
323848007199	dimerization interface [polypeptide binding]; other site
323848007200	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848007201	Walker A motif; other site
323848007202	ATP binding site [chemical binding]; other site
323848007203	Walker B motif; other site
323848007204	arginine finger; other site
323848007205	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
323848007206	putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916
323848007207	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848007208	ATP binding site [chemical binding]; other site
323848007209	Mg2+ binding site [ion binding]; other site
323848007210	G-X-G motif; other site
323848007211	sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013
323848007212	Bacterial sugar transferase; Region: Bac_transf; cl00939
323848007213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944
323848007214	active site
323848007215	phosphorylation site [posttranslational modification]
323848007216	intermolecular recognition site; other site
323848007217	dimerization interface [polypeptide binding]; other site
323848007218	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
323848007219	DNA binding residues [nucleotide binding]
323848007220	dimerization interface [polypeptide binding]; other site
323848007221	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
323848007222	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
323848007223	Domain of unknown function (DUF2024); Region: DUF2024; pfam09630
323848007224	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
323848007225	TIGR03545 family protein; Region: TIGR03545
323848007226	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
323848007227	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
323848007228	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
323848007229	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
323848007230	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
323848007231	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
323848007232	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
323848007233	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
323848007234	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966
323848007235	catalytic residues [active]
323848007236	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
323848007237	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
323848007238	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515
323848007239	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
323848007240	DsbD alpha interface [polypeptide binding]; other site
323848007241	catalytic residues [active]
323848007242	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
323848007243	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
323848007244	putative NAD(P) binding site [chemical binding]; other site
323848007245	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
323848007246	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
323848007247	catalytic loop [active]
323848007248	iron binding site [ion binding]; other site
323848007249	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD...; Region: flavin_oxioreductase; cd06189
323848007250	FAD binding pocket [chemical binding]; other site
323848007251	FAD binding motif [chemical binding]; other site
323848007252	phosphate binding motif [ion binding]; other site
323848007253	beta-alpha-beta structure motif; other site
323848007254	NAD binding pocket [chemical binding]; other site
323848007255	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
323848007256	HemY protein N-terminus; Region: HemY_N; pfam07219
323848007257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
323848007258	binding surface
323848007259	TPR motif; other site
323848007260	HemX; Region: HemX; cl14667
323848007261	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
323848007262	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578
323848007263	active site
323848007264	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
323848007265	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
323848007266	domain interfaces; other site
323848007267	active site
323848007268	Phosphoenolpyruvate carboxylase [Carbohydrate transport and    metabolism; Energy production and conversion]; Region: COG1892; cl14656
323848007269	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
323848007270	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
323848007271	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
323848007272	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
323848007273	FeS/SAM binding site; other site
323848007274	TRAM domain; Region: TRAM; cl01282
323848007275	Response regulator receiver domain; Region: Response_reg; pfam00072
323848007276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848007277	active site
323848007278	phosphorylation site [posttranslational modification]
323848007279	intermolecular recognition site; other site
323848007280	dimerization interface [polypeptide binding]; other site
323848007281	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848007282	metal binding site [ion binding]; metal-binding site
323848007283	active site
323848007284	I-site; other site
323848007285	PAS fold; Region: PAS_4; pfam08448
323848007286	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848007287	putative active site [active]
323848007288	heme pocket [chemical binding]; other site
323848007289	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
323848007290	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
323848007291	ATP binding site [chemical binding]; other site
323848007292	Mg2+ binding site [ion binding]; other site
323848007293	G-X-G motif; other site
323848007294	Response regulator receiver domain; Region: Response_reg; pfam00072
323848007295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848007296	active site
323848007297	phosphorylation site [posttranslational modification]
323848007298	intermolecular recognition site; other site
323848007299	dimerization interface [polypeptide binding]; other site
323848007300	Response regulator receiver domain; Region: Response_reg; pfam00072
323848007301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
323848007302	active site
323848007303	phosphorylation site [posttranslational modification]
323848007304	intermolecular recognition site; other site
323848007305	dimerization interface [polypeptide binding]; other site
323848007306	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
323848007307	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
323848007308	PhoH-like protein; Region: PhoH; cl12134
323848007309	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
323848007310	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
323848007311	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
323848007312	Transporter associated domain; Region: CorC_HlyC; pfam03471
323848007313	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
323848007314	substrate binding site [chemical binding]; other site
323848007315	metal binding sites [ion binding]; metal-binding site
323848007316	ABC transporter ATPase component; Reviewed; Region: PRK11147
323848007317	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848007318	Walker A/P-loop; other site
323848007319	ATP binding site [chemical binding]; other site
323848007320	Q-loop/lid; other site
323848007321	ABC transporter signature motif; other site
323848007322	Walker B; other site
323848007323	D-loop; other site
323848007324	H-loop/switch region; other site
323848007325	ABC transporter; Region: ABC_tran_2; pfam12848
323848007326	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
323848007327	Cytochrome c; Region: Cytochrom_C; cl11414
323848007328	Cytochrome c; Region: Cytochrom_C; cl11414
323848007329	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
323848007330	endonuclease III; Provisional; Region: PRK10702
323848007331	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
323848007332	minor groove reading motif; other site
323848007333	helix-hairpin-helix signature motif; other site
323848007334	substrate binding pocket [chemical binding]; other site
323848007335	active site
323848007336	FES domain; Region: FES; smart00525
323848007337	electron transport complex protein RnfB; Provisional; Region: PRK05113
323848007338	Putative Fe-S cluster; Region: FeS; pfam04060
323848007339	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738
323848007340	quinone interaction residues [chemical binding]; other site
323848007341	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
323848007342	active site
323848007343	catalytic residues [active]
323848007344	FMN binding site [chemical binding]; other site
323848007345	substrate binding site [chemical binding]; other site
323848007346	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848007347	binding surface
323848007348	TPR motif; other site
323848007349	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
323848007350	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
323848007351	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
323848007352	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
323848007353	Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006
323848007354	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
323848007355	Ligand Binding Site [chemical binding]; other site
323848007356	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
323848007357	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
323848007358	FeS/SAM binding site; other site
323848007359	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
323848007360	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
323848007361	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
323848007362	binding surface
323848007363	TPR motif; other site
323848007364	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
323848007365	ligand binding site [chemical binding]; other site
323848007366	translocation protein TolB; Provisional; Region: tolB; PRK02889
323848007367	TolB amino-terminal domain; Region: TolB_N; pfam04052
323848007368	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
323848007369	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
323848007370	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
323848007371	Gram-negative bacterial tonB protein; Region: TonB; cl10048
323848007372	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
323848007373	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
323848007374	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
323848007375	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
323848007376	active site
323848007377	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
323848007378	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
323848007379	Walker A motif; other site
323848007380	ATP binding site [chemical binding]; other site
323848007381	Walker B motif; other site
323848007382	arginine finger; other site
323848007383	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
323848007384	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
323848007385	RuvA N terminal domain; Region: RuvA_N; pfam01330
323848007386	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
323848007387	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
323848007388	dimer interface [polypeptide binding]; other site
323848007389	putative DNA-binding cleft [nucleotide binding]; other site
323848007390	Domain of unknown function DUF28; Region: DUF28; cl00361
323848007391	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
323848007392	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
323848007393	Uncharacterized conserved protein [Function unknown]; Region: COG4748
323848007394	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
323848007395	PAS fold; Region: PAS_4; pfam08448
323848007396	PAS domain S-box; Region: sensory_box; TIGR00229
323848007397	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
323848007398	putative active site [active]
323848007399	heme pocket [chemical binding]; other site
323848007400	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
323848007401	metal binding site [ion binding]; metal-binding site
323848007402	active site
323848007403	I-site; other site
323848007404	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
323848007405	dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361
323848007406	DAK2 domain; Region: Dak2; cl03685
323848007407	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
323848007408	hydrophobic ligand binding site; other site
323848007409	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
323848007410	PEP-CTERM motif; Region: VPEP; pfam07589
323848007411	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
323848007412	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
323848007413	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
323848007414	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
323848007415	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485
323848007416	generic binding surface II; other site
323848007417	generic binding surface I; other site
323848007418	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
323848007419	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
323848007420	catalytic residue [active]
323848007421	Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878
323848007422	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
323848007423	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
323848007424	active site
323848007425	(T/H)XGH motif; other site
323848007426	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848007427	S-adenosylmethionine binding site [chemical binding]; other site
323848007428	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
323848007429	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
323848007430	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
323848007431	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
323848007432	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
323848007433	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
323848007434	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
323848007435	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
323848007436	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
323848007437	P loop; other site
323848007438	GTP binding site [chemical binding]; other site
323848007439	Type II (General) Secretory Pathway (IISP) Family protein; Region: 3a0501s02; TIGR00960
323848007440	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848007441	Walker A/P-loop; other site
323848007442	ATP binding site [chemical binding]; other site
323848007443	Q-loop/lid; other site
323848007444	ABC transporter signature motif; other site
323848007445	Walker B; other site
323848007446	D-loop; other site
323848007447	H-loop/switch region; other site
323848007448	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
323848007449	FtsX-like permease family; Region: FtsX; pfam02687
323848007450	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
323848007451	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
323848007452	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
323848007453	DNA binding residues [nucleotide binding]
323848007454	BolA-like protein; Region: BolA; cl00386
323848007455	ABC-2 type transporter; Region: ABC2_membrane; cl11417
323848007456	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
323848007457	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848007458	Walker A/P-loop; other site
323848007459	ATP binding site [chemical binding]; other site
323848007460	Q-loop/lid; other site
323848007461	ABC transporter signature motif; other site
323848007462	Walker B; other site
323848007463	D-loop; other site
323848007464	H-loop/switch region; other site
323848007465	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
323848007466	anti sigma factor interaction site; other site
323848007467	regulatory phosphorylation site [posttranslational modification]; other site
323848007468	ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074
323848007469	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
323848007470	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
323848007471	mce related protein; Region: MCE; cl03606
323848007472	Domain of unknown function DUF140; Region: DUF140; cl00510
323848007473	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
323848007474	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
323848007475	Walker A/P-loop; other site
323848007476	ATP binding site [chemical binding]; other site
323848007477	Q-loop/lid; other site
323848007478	ABC transporter signature motif; other site
323848007479	Walker B; other site
323848007480	D-loop; other site
323848007481	H-loop/switch region; other site
323848007482	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
323848007483	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
323848007484	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
323848007485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
323848007486	S-adenosylmethionine binding site [chemical binding]; other site
323848007487	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
323848007488	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
323848007489	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
323848007490	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
323848007491	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
323848007492	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
323848007493	carboxyltransferase (CT) interaction site; other site
323848007494	biotinylation site [posttranslational modification]; other site
323848007495	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
323848007496	trimer interface [polypeptide binding]; other site
323848007497	active site
323848007498	dimer interface [polypeptide binding]; other site
323848007499	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
323848007500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
323848007501	putative substrate translocation pore; other site
323848007502	Copper resistance protein D; Region: CopD; cl00563
323848007503	Cytochrome c; Region: Cytochrom_C; cl11414
323848007504	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
323848007505	Copper resistance protein CopC; Region: CopC; cl01012
323848007506	Monooxygenase subunit B protein; Region: Monooxygenase_B; cl04718
323848007507	Ammonia monooxygenase; Region: AMO; cl03602
323848007508	Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; cl04829
323848007509	ParB-like partition proteins; Region: parB_part; TIGR00180
323848007510	ParB-like nuclease domain; Region: ParBc; cl02129
323848007511	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
323848007512	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
323848007513	P-loop; other site
323848007514	Magnesium ion binding site [ion binding]; other site
323848007515	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
323848007516	Magnesium ion binding site [ion binding]; other site
323848007517	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
323848007518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848007519	Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445
323848007520	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520
323848007521	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848007522	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
323848007523	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
323848007524	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
323848007525	TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes.  It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes.  TrmE contains a GTPase...; Region: trmE; cd04164
323848007526	G1 box; other site
323848007527	GTP/Mg2+ binding site [chemical binding]; other site
323848007528	Switch I region; other site
323848007529	G2 box; other site
323848007530	Switch II region; other site
323848007531	G3 box; other site
323848007532	G4 box; other site
323848007533	G5 box; other site
323848007534	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
323848007535	membrane protein insertase; Provisional; Region: PRK01318
323848007536	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
323848007537	Domain of unknown function DUF37; Region: DUF37; cl00506
323848007538	Ribonuclease P; Region: Ribonuclease_P; cl00457
323848007539	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
323848007540	AAA-like domain; Region: AAA_10; pfam12846
323848007541	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888
323848007542	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
323848007543	Phd_YefM; Region: PhdYeFM; cl09153
323848007544	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
323848007545	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
323848007546	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
323848007547	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
323848007548	Phage integrase family; Region: Phage_integrase; pfam00589
323848007549	DNA binding site [nucleotide binding]
323848007550	Int/Topo IB signature motif; other site
323848007551	active site
323848007552	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cd02259
323848007553	putative active site [active]
323848007554	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
323848007555	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
323848007556	RHS Repeat; Region: RHS_repeat; cl11982
323848007557	RHS Repeat; Region: RHS_repeat; cl11982
323848007558	RHS Repeat; Region: RHS_repeat; cl11982
323848007559	RHS Repeat; Region: RHS_repeat; cl11982
323848007560	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
323848007561	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
323848007562	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
323848007563	P-loop; other site
323848007564	Magnesium ion binding site [ion binding]; other site
323848007565	Abi-like protein; Region: Abi_2; cl01988
323848007566	Domain of unknown function (DUF955); Region: DUF955; cl01076
323848007567	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
323848007568	Integrase core domain; Region: rve; cl01316
323848007569	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848007570	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
323848007571	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848007572	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
323848007573	ParA-like protein; Provisional; Region: PHA02518
323848007574	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
323848007575	P-loop; other site
323848007576	Magnesium ion binding site [ion binding]; other site
323848007577	Replication initiator protein A; Region: RPA; cl02339
323848007578	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
323848007579	MAEBL; Provisional; Region: PTZ00121
323848007580	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
323848007581	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
323848007582	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
323848007583	AAA-like domain; Region: AAA_10; pfam12846
323848007584	Walker A motif; other site
323848007585	ATP binding site [chemical binding]; other site
323848007586	Walker B motif; other site
323848007587	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
323848007588	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
323848007589	DNA-binding interface [nucleotide binding]; DNA binding site
323848007590	multiple promoter invertase; Provisional; Region: mpi; PRK13413
323848007591	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
323848007592	catalytic residues [active]
323848007593	catalytic nucleophile [active]
323848007594	Presynaptic Site I dimer interface [polypeptide binding]; other site
323848007595	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
323848007596	Synaptic Flat tetramer interface [polypeptide binding]; other site
323848007597	Synaptic Site I dimer interface [polypeptide binding]; other site
323848007598	DNA binding site [nucleotide binding]
323848007599	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
323848007600	DNA-binding interface [nucleotide binding]; DNA binding site
323848007601	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
323848007602	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
323848007603	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
323848007604	P-loop; other site
323848007605	Magnesium ion binding site [ion binding]; other site
323848007606	Replication initiator protein A; Region: RPA; cl02339
323848007607	Conjugal transfer protein TraD; Region: TraD; cl05753
323848007608	MobA/MobL family; Region: MobA_MobL; pfam03389
323848007609	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
323848007610	cleavage site
323848007611	active site
323848007612	substrate binding sites [chemical binding]; other site
323848007613	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
323848007614	putative transposase OrfB; Reviewed; Region: PHA02517
323848007615	Integrase core domain; Region: rve; cl01316
323848007616	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
323848007617	non-specific DNA binding site [nucleotide binding]; other site
323848007618	salt bridge; other site
323848007619	sequence-specific DNA binding site [nucleotide binding]; other site