-- dump date 20120504_153926 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1127134000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1127134000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134000003 Walker A motif; other site 1127134000004 ATP binding site [chemical binding]; other site 1127134000005 Walker B motif; other site 1127134000006 arginine finger; other site 1127134000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1127134000008 DnaA box-binding interface [nucleotide binding]; other site 1127134000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1127134000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1127134000011 putative DNA binding surface [nucleotide binding]; other site 1127134000012 dimer interface [polypeptide binding]; other site 1127134000013 beta-clamp/clamp loader binding surface; other site 1127134000014 beta-clamp/translesion DNA polymerase binding surface; other site 1127134000015 recombination protein F; Reviewed; Region: recF; PRK00064 1127134000016 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 1127134000017 Walker A/P-loop; other site 1127134000018 ATP binding site [chemical binding]; other site 1127134000019 Q-loop/lid; other site 1127134000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134000021 ABC transporter signature motif; other site 1127134000022 Walker B; other site 1127134000023 D-loop; other site 1127134000024 H-loop/switch region; other site 1127134000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 1127134000026 short chain dehydrogenase; Validated; Region: PRK05855 1127134000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1127134000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134000029 ATP binding site [chemical binding]; other site 1127134000030 Mg2+ binding site [ion binding]; other site 1127134000031 G-X-G motif; other site 1127134000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1127134000033 anchoring element; other site 1127134000034 dimer interface [polypeptide binding]; other site 1127134000035 ATP binding site [chemical binding]; other site 1127134000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1127134000037 active site 1127134000038 putative metal-binding site [ion binding]; other site 1127134000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1127134000040 DNA gyrase subunit A; Validated; Region: PRK05560 1127134000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1127134000042 CAP-like domain; other site 1127134000043 active site 1127134000044 primary dimer interface [polypeptide binding]; other site 1127134000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127134000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127134000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127134000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127134000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127134000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127134000051 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1127134000052 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1127134000053 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1127134000054 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134000055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134000056 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1127134000057 Walker A/P-loop; other site 1127134000058 ATP binding site [chemical binding]; other site 1127134000059 Q-loop/lid; other site 1127134000060 ABC transporter signature motif; other site 1127134000061 Walker B; other site 1127134000062 D-loop; other site 1127134000063 H-loop/switch region; other site 1127134000064 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134000065 Rhomboid family; Region: Rhomboid; cl11446 1127134000066 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 1127134000067 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1127134000068 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1127134000069 glutamine binding [chemical binding]; other site 1127134000070 catalytic triad [active] 1127134000071 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134000072 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1127134000073 catalytic motif [active] 1127134000074 Zn binding site [ion binding]; other site 1127134000075 FOG: CBS domain [General function prediction only]; Region: COG0517 1127134000076 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1127134000077 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134000078 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134000079 active site 1127134000080 ATP binding site [chemical binding]; other site 1127134000081 substrate binding site [chemical binding]; other site 1127134000082 activation loop (A-loop); other site 1127134000083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1127134000084 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1127134000085 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1127134000086 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1127134000087 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1127134000088 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134000089 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134000090 active site 1127134000091 ATP binding site [chemical binding]; other site 1127134000092 substrate binding site [chemical binding]; other site 1127134000093 activation loop (A-loop); other site 1127134000094 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134000095 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1127134000096 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1127134000097 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1127134000098 active site 1127134000099 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1127134000100 phosphopeptide binding site; other site 1127134000101 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1127134000102 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1127134000103 phosphopeptide binding site; other site 1127134000104 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1127134000105 FAD binding domain; Region: FAD_binding_4; pfam01565 1127134000106 Berberine and berberine like; Region: BBE; pfam08031 1127134000107 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1127134000108 classical (c) SDRs; Region: SDR_c; cd05233 1127134000109 NAD(P) binding site [chemical binding]; other site 1127134000110 active site 1127134000111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134000112 Integral membrane protein DUF95; Region: DUF95; cl00572 1127134000113 RDD family; Region: RDD; cl00746 1127134000114 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1127134000115 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1127134000116 MoxR-like ATPases [General function prediction only]; Region: COG0714 1127134000117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134000118 Walker A motif; other site 1127134000119 ATP binding site [chemical binding]; other site 1127134000120 Walker B motif; other site 1127134000121 arginine finger; other site 1127134000122 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134000123 Helix-turn-helix domains; Region: HTH; cl00088 1127134000124 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1127134000125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134000126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127134000127 dimerization interface [polypeptide binding]; other site 1127134000128 cyclase homology domain; Region: CHD; cd07302 1127134000129 nucleotidyl binding site; other site 1127134000130 metal binding site [ion binding]; metal-binding site 1127134000131 dimer interface [polypeptide binding]; other site 1127134000132 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1127134000133 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1127134000134 active site 1127134000135 dimer interface [polypeptide binding]; other site 1127134000136 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1127134000137 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1127134000138 active site 1127134000139 FMN binding site [chemical binding]; other site 1127134000140 substrate binding site [chemical binding]; other site 1127134000141 3Fe-4S cluster binding site [ion binding]; other site 1127134000142 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1127134000143 domain interface; other site 1127134000144 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1127134000145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000146 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1127134000147 EspG family; Region: ESX-1_EspG; pfam14011 1127134000148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134000149 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134000150 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1127134000151 oligomeric interface; other site 1127134000152 putative active site [active] 1127134000153 homodimer interface [polypeptide binding]; other site 1127134000154 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127134000155 catalytic core [active] 1127134000156 Cutinase; Region: Cutinase; pfam01083 1127134000157 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1127134000158 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1127134000159 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1127134000160 dimer interface [polypeptide binding]; other site 1127134000161 putative anticodon binding site; other site 1127134000162 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1127134000163 motif 1; other site 1127134000164 dimer interface [polypeptide binding]; other site 1127134000165 active site 1127134000166 motif 2; other site 1127134000167 motif 3; other site 1127134000168 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127134000169 RNA binding surface [nucleotide binding]; other site 1127134000170 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1127134000171 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1127134000172 hydrophobic ligand binding site; other site 1127134000173 Bacterial Ig-like domain; Region: Big_5; cl01012 1127134000174 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1127134000175 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1127134000176 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1127134000177 heat shock protein 90; Provisional; Region: PRK05218 1127134000178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1127134000179 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134000180 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1127134000181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000182 NAD(P) binding site [chemical binding]; other site 1127134000183 active site 1127134000184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000185 NAD(P) binding site [chemical binding]; other site 1127134000186 active site 1127134000187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134000188 Helix-turn-helix domains; Region: HTH; cl00088 1127134000189 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1127134000190 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1127134000191 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1127134000192 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1127134000193 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1127134000194 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1127134000195 active site residue [active] 1127134000196 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1127134000197 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1127134000198 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1127134000199 putative active site [active] 1127134000200 catalytic site [active] 1127134000201 putative metal binding site [ion binding]; other site 1127134000202 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1127134000203 Ferritin-like domain; Region: Ferritin; pfam00210 1127134000204 ferroxidase diiron center [ion binding]; other site 1127134000205 Ferritin-like domain; Region: Ferritin; pfam00210 1127134000206 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1127134000207 dinuclear metal binding motif [ion binding]; other site 1127134000208 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1127134000209 CAAX protease self-immunity; Region: Abi; cl00558 1127134000210 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1127134000211 prephenate dehydratase; Provisional; Region: PRK11898 1127134000212 Prephenate dehydratase; Region: PDT; pfam00800 1127134000213 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1127134000214 putative L-Phe binding site [chemical binding]; other site 1127134000215 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127134000216 catalytic core [active] 1127134000217 EspG family; Region: ESX-1_EspG; pfam14011 1127134000218 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 1127134000219 Septum formation; Region: Septum_form; pfam13845 1127134000220 Septum formation; Region: Septum_form; pfam13845 1127134000221 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1127134000222 NAD(P) binding site [chemical binding]; other site 1127134000223 catalytic residues [active] 1127134000224 seryl-tRNA synthetase; Provisional; Region: PRK05431 1127134000225 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1127134000226 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 1127134000227 dimer interface [polypeptide binding]; other site 1127134000228 active site 1127134000229 motif 1; other site 1127134000230 motif 2; other site 1127134000231 motif 3; other site 1127134000232 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1127134000233 metal binding site [ion binding]; metal-binding site 1127134000234 active site 1127134000235 I-site; other site 1127134000236 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1127134000237 Protein of unknown function, DUF606; Region: DUF606; cl01273 1127134000238 Protein of unknown function, DUF606; Region: DUF606; cl01273 1127134000239 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134000240 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1127134000241 iron-sulfur cluster [ion binding]; other site 1127134000242 [2Fe-2S] cluster binding site [ion binding]; other site 1127134000243 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1127134000244 putative acyl-acceptor binding pocket; other site 1127134000245 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1127134000246 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1127134000247 metal-binding site [ion binding] 1127134000248 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1127134000249 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1127134000250 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1127134000251 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1127134000252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134000253 putative substrate translocation pore; other site 1127134000254 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1127134000255 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1127134000256 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134000257 DNA-binding site [nucleotide binding]; DNA binding site 1127134000258 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1127134000259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127134000260 Coenzyme A binding pocket [chemical binding]; other site 1127134000261 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1127134000262 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1127134000263 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1127134000264 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1127134000265 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1127134000266 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1127134000267 Walker A/P-loop; other site 1127134000268 ATP binding site [chemical binding]; other site 1127134000269 Q-loop/lid; other site 1127134000270 ABC transporter signature motif; other site 1127134000271 Walker B; other site 1127134000272 D-loop; other site 1127134000273 H-loop/switch region; other site 1127134000274 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1127134000275 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1127134000276 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1127134000277 Walker A/P-loop; other site 1127134000278 ATP binding site [chemical binding]; other site 1127134000279 Q-loop/lid; other site 1127134000280 ABC transporter signature motif; other site 1127134000281 Walker B; other site 1127134000282 D-loop; other site 1127134000283 H-loop/switch region; other site 1127134000284 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1127134000285 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1127134000286 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1127134000287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134000288 dimer interface [polypeptide binding]; other site 1127134000289 conserved gate region; other site 1127134000290 putative PBP binding loops; other site 1127134000291 ABC-ATPase subunit interface; other site 1127134000292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134000293 dimer interface [polypeptide binding]; other site 1127134000294 conserved gate region; other site 1127134000295 putative PBP binding loops; other site 1127134000296 ABC-ATPase subunit interface; other site 1127134000297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134000298 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1127134000299 active site 1127134000300 motif I; other site 1127134000301 motif II; other site 1127134000302 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1127134000303 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1127134000304 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1127134000305 amidase catalytic site [active] 1127134000306 Zn binding residues [ion binding]; other site 1127134000307 substrate binding site [chemical binding]; other site 1127134000308 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1127134000309 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1127134000310 Stage II sporulation protein; Region: SpoIID; pfam08486 1127134000311 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134000312 DNA binding residues [nucleotide binding] 1127134000313 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1127134000314 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1127134000315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000316 UDP-galactopyranose mutase; Region: GLF; pfam03275 1127134000317 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1127134000318 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1127134000319 active site 1127134000320 UbiA prenyltransferase family; Region: UbiA; cl00337 1127134000321 Predicted esterase [General function prediction only]; Region: COG0627 1127134000322 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134000323 Predicted esterase [General function prediction only]; Region: COG0627 1127134000324 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134000325 Predicted esterase [General function prediction only]; Region: COG0627 1127134000326 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134000327 Predicted esterase [General function prediction only]; Region: COG0627 1127134000328 LGFP repeat; Region: LGFP; pfam08310 1127134000329 LGFP repeat; Region: LGFP; pfam08310 1127134000330 LGFP repeat; Region: LGFP; pfam08310 1127134000331 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1127134000332 Cutinase; Region: Cutinase; pfam01083 1127134000333 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1127134000334 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134000335 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1127134000336 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134000337 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134000338 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127134000339 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1127134000340 active site 1127134000341 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1127134000342 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1127134000343 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134000344 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1127134000345 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1127134000346 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134000347 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134000348 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 1127134000349 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1127134000350 substrate binding site [chemical binding]; other site 1127134000351 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1127134000352 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1127134000353 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1127134000354 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1127134000355 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1127134000356 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1127134000357 classical (c) SDRs; Region: SDR_c; cd05233 1127134000358 NAD(P) binding site [chemical binding]; other site 1127134000359 active site 1127134000360 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1127134000361 FAD binding domain; Region: FAD_binding_4; pfam01565 1127134000362 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 1127134000363 GtrA-like protein; Region: GtrA; cl00971 1127134000364 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134000365 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 1127134000366 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134000367 Cupin domain; Region: Cupin_2; cl09118 1127134000368 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1127134000369 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1127134000370 substrate binding site; other site 1127134000371 tetramer interface; other site 1127134000372 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134000373 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1127134000374 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1127134000375 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1127134000376 NAD binding site [chemical binding]; other site 1127134000377 substrate binding site [chemical binding]; other site 1127134000378 homodimer interface [polypeptide binding]; other site 1127134000379 active site 1127134000380 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1127134000381 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1127134000382 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1127134000383 Ligand binding site; other site 1127134000384 Putative Catalytic site; other site 1127134000385 DXD motif; other site 1127134000386 GtrA-like protein; Region: GtrA; cl00971 1127134000387 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1127134000388 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1127134000389 active site 1127134000390 short chain dehydrogenase; Provisional; Region: PRK08278 1127134000391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000392 NAD(P) binding site [chemical binding]; other site 1127134000393 active site 1127134000394 GTPase RsgA; Reviewed; Region: PRK01889 1127134000395 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1127134000396 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1127134000397 GTP/Mg2+ binding site [chemical binding]; other site 1127134000398 G4 box; other site 1127134000399 G5 box; other site 1127134000400 G1 box; other site 1127134000401 Switch I region; other site 1127134000402 G2 box; other site 1127134000403 G3 box; other site 1127134000404 Switch II region; other site 1127134000405 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1127134000406 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1127134000407 active site 1127134000408 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1127134000409 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 1127134000410 Walker A/P-loop; other site 1127134000411 ATP binding site [chemical binding]; other site 1127134000412 Q-loop/lid; other site 1127134000413 ABC transporter signature motif; other site 1127134000414 Walker B; other site 1127134000415 D-loop; other site 1127134000416 H-loop/switch region; other site 1127134000417 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134000418 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1127134000419 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1127134000420 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134000421 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134000422 catalytic residue [active] 1127134000423 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1127134000424 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1127134000425 NAD(P) binding site [chemical binding]; other site 1127134000426 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1127134000427 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1127134000428 putative active site [active] 1127134000429 putative substrate binding site [chemical binding]; other site 1127134000430 putative FMN binding site [chemical binding]; other site 1127134000431 putative catalytic residues [active] 1127134000432 Helix-turn-helix domains; Region: HTH; cl00088 1127134000433 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127134000434 Predicted esterase [General function prediction only]; Region: COG0627 1127134000435 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134000436 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1127134000437 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127134000438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134000439 homodimer interface [polypeptide binding]; other site 1127134000440 catalytic residue [active] 1127134000441 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1127134000442 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134000443 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1127134000444 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1127134000445 Arginase family; Region: Arginase; cl00306 1127134000446 imidazolonepropionase; Provisional; Region: PRK14085 1127134000447 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1127134000448 active site 1127134000449 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1127134000450 Na binding site [ion binding]; other site 1127134000451 putative proline-specific permease; Provisional; Region: proY; PRK10580 1127134000452 Spore germination protein; Region: Spore_permease; cl15802 1127134000453 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1127134000454 active sites [active] 1127134000455 tetramer interface [polypeptide binding]; other site 1127134000456 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1127134000457 RNA binding site [nucleotide binding]; other site 1127134000458 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134000459 active site 1127134000460 ATP binding site [chemical binding]; other site 1127134000461 substrate binding site [chemical binding]; other site 1127134000462 activation loop (A-loop); other site 1127134000463 urocanate hydratase; Provisional; Region: PRK05414 1127134000464 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1127134000465 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1127134000466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134000467 DNA-binding site [nucleotide binding]; DNA binding site 1127134000468 UTRA domain; Region: UTRA; cl01230 1127134000469 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1127134000470 additional DNA contacts [nucleotide binding]; other site 1127134000471 mismatch recognition site; other site 1127134000472 active site 1127134000473 zinc binding site [ion binding]; other site 1127134000474 DNA intercalation site [nucleotide binding]; other site 1127134000475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134000476 cofactor binding site; other site 1127134000477 DNA binding site [nucleotide binding] 1127134000478 substrate interaction site [chemical binding]; other site 1127134000479 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1127134000480 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127134000481 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1127134000482 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134000483 Walker A/P-loop; other site 1127134000484 ATP binding site [chemical binding]; other site 1127134000485 Q-loop/lid; other site 1127134000486 ABC transporter signature motif; other site 1127134000487 Walker B; other site 1127134000488 D-loop; other site 1127134000489 H-loop/switch region; other site 1127134000490 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127134000491 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1127134000492 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134000493 Walker A/P-loop; other site 1127134000494 ATP binding site [chemical binding]; other site 1127134000495 Q-loop/lid; other site 1127134000496 ABC transporter signature motif; other site 1127134000497 Walker B; other site 1127134000498 D-loop; other site 1127134000499 H-loop/switch region; other site 1127134000500 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 1127134000501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000502 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1127134000503 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1127134000504 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1127134000505 nucleoside/Zn binding site; other site 1127134000506 dimer interface [polypeptide binding]; other site 1127134000507 catalytic motif [active] 1127134000508 Helix-turn-helix domain; Region: HTH_18; pfam12833 1127134000509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134000510 Cytochrome P450; Region: p450; pfam00067 1127134000511 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134000512 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134000513 DNA binding residues [nucleotide binding] 1127134000514 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1127134000515 FAD binding domain; Region: FAD_binding_3; pfam01494 1127134000516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000517 Helix-turn-helix domains; Region: HTH; cl00088 1127134000518 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1127134000519 Helix-turn-helix domains; Region: HTH; cl00088 1127134000520 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1127134000521 dimerization interface [polypeptide binding]; other site 1127134000522 substrate binding pocket [chemical binding]; other site 1127134000523 short chain dehydrogenase; Provisional; Region: PRK06180 1127134000524 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1127134000525 NADP binding site [chemical binding]; other site 1127134000526 active site 1127134000527 steroid binding site; other site 1127134000528 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127134000529 Cation efflux family; Region: Cation_efflux; cl00316 1127134000530 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134000531 Helix-turn-helix domains; Region: HTH; cl00088 1127134000532 Predicted transcriptional regulator [Transcription]; Region: COG1959 1127134000533 Helix-turn-helix domains; Region: HTH; cl00088 1127134000534 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127134000535 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1127134000536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134000537 Walker A/P-loop; other site 1127134000538 ATP binding site [chemical binding]; other site 1127134000539 Q-loop/lid; other site 1127134000540 ABC transporter signature motif; other site 1127134000541 Walker B; other site 1127134000542 D-loop; other site 1127134000543 H-loop/switch region; other site 1127134000544 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1127134000545 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1127134000546 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1127134000547 Walker A/P-loop; other site 1127134000548 ATP binding site [chemical binding]; other site 1127134000549 Q-loop/lid; other site 1127134000550 ABC transporter signature motif; other site 1127134000551 Walker B; other site 1127134000552 D-loop; other site 1127134000553 H-loop/switch region; other site 1127134000554 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1127134000555 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1127134000556 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1127134000557 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1127134000558 RDD family; Region: RDD; cl00746 1127134000559 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1127134000560 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1127134000561 active site 1127134000562 HIGH motif; other site 1127134000563 nucleotide binding site [chemical binding]; other site 1127134000564 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1127134000565 active site 1127134000566 KMSKS motif; other site 1127134000567 Domain of unknown function (DUF309); Region: DUF309; cl00667 1127134000568 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134000569 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1127134000570 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1127134000571 heme bH binding site [chemical binding]; other site 1127134000572 intrachain domain interface; other site 1127134000573 heme bL binding site [chemical binding]; other site 1127134000574 interchain domain interface [polypeptide binding]; other site 1127134000575 Qo binding site; other site 1127134000576 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1127134000577 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1127134000578 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1127134000579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000580 NAD(P) binding site [chemical binding]; other site 1127134000581 active site 1127134000582 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1127134000583 active site 1127134000584 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134000585 Ubiquitin-like proteins; Region: UBQ; cl00155 1127134000586 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 1127134000587 Protein of unknown function DUF82; Region: DUF82; pfam01927 1127134000588 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1127134000589 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1127134000590 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134000591 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134000592 catalytic residue [active] 1127134000593 hypothetical protein; Provisional; Region: PRK08317 1127134000594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134000595 S-adenosylmethionine binding site [chemical binding]; other site 1127134000596 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1127134000597 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134000598 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1127134000599 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1127134000600 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1127134000601 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134000602 HTH-like domain; Region: HTH_21; pfam13276 1127134000603 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1127134000604 Integrase core domain; Region: rve; cl01316 1127134000605 Integrase core domain; Region: rve_3; cl15866 1127134000606 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1127134000607 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 1127134000608 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 1127134000609 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 1127134000610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134000611 Helix-turn-helix domains; Region: HTH; cl00088 1127134000612 WHG domain; Region: WHG; pfam13305 1127134000613 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127134000614 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1127134000615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134000616 Walker A motif; other site 1127134000617 ATP binding site [chemical binding]; other site 1127134000618 Walker B motif; other site 1127134000619 arginine finger; other site 1127134000620 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1127134000621 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1127134000622 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1127134000623 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1127134000624 dimer interface [polypeptide binding]; other site 1127134000625 active site 1127134000626 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1127134000627 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134000628 substrate binding site [chemical binding]; other site 1127134000629 oxyanion hole (OAH) forming residues; other site 1127134000630 trimer interface [polypeptide binding]; other site 1127134000631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000632 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1127134000633 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1127134000634 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1127134000635 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134000636 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134000637 active site 1127134000638 ATP binding site [chemical binding]; other site 1127134000639 substrate binding site [chemical binding]; other site 1127134000640 activation loop (A-loop); other site 1127134000641 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1127134000642 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1127134000643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134000644 S-adenosylmethionine binding site [chemical binding]; other site 1127134000645 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1127134000646 FAD binding domain; Region: FAD_binding_4; pfam01565 1127134000647 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134000648 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1127134000649 active site 1127134000650 metal binding site [ion binding]; metal-binding site 1127134000651 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1127134000652 DNA binding residues [nucleotide binding] 1127134000653 drug binding residues [chemical binding]; other site 1127134000654 dimer interface [polypeptide binding]; other site 1127134000655 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1127134000656 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1127134000657 recombination protein RecR; Reviewed; Region: recR; PRK00076 1127134000658 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1127134000659 RecR protein; Region: RecR; pfam02132 1127134000660 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1127134000661 putative active site [active] 1127134000662 putative metal-binding site [ion binding]; other site 1127134000663 tetramer interface [polypeptide binding]; other site 1127134000664 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1127134000665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000666 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134000667 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1127134000668 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1127134000669 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1127134000670 catalytic triad [active] 1127134000671 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1127134000672 EamA-like transporter family; Region: EamA; cl01037 1127134000673 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127134000674 Helix-turn-helix domains; Region: HTH; cl00088 1127134000675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134000676 dimerization interface [polypeptide binding]; other site 1127134000677 Cytadhesin P30/P32; Region: Cytadhesin_P30; pfam07271 1127134000678 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1127134000679 2-isopropylmalate synthase; Validated; Region: PRK03739 1127134000680 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1127134000681 active site 1127134000682 catalytic residues [active] 1127134000683 metal binding site [ion binding]; metal-binding site 1127134000684 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1127134000685 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1127134000686 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1127134000687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000689 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1127134000690 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1127134000691 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1127134000692 putative hydrophobic ligand binding site [chemical binding]; other site 1127134000693 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1127134000694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134000695 Helix-turn-helix domains; Region: HTH; cl00088 1127134000696 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134000697 NADP+ binding site [chemical binding]; other site 1127134000698 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134000699 NADP+ binding site [chemical binding]; other site 1127134000700 aspartate kinase; Reviewed; Region: PRK06635 1127134000701 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1127134000702 putative nucleotide binding site [chemical binding]; other site 1127134000703 putative catalytic residues [active] 1127134000704 putative Mg ion binding site [ion binding]; other site 1127134000705 putative aspartate binding site [chemical binding]; other site 1127134000706 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1127134000707 putative allosteric regulatory site; other site 1127134000708 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1127134000709 putative allosteric regulatory residue; other site 1127134000710 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1127134000711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000712 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1127134000713 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134000714 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1127134000715 metal binding site 2 [ion binding]; metal-binding site 1127134000716 putative DNA binding helix; other site 1127134000717 metal binding site 1 [ion binding]; metal-binding site 1127134000718 dimer interface [polypeptide binding]; other site 1127134000719 structural Zn2+ binding site [ion binding]; other site 1127134000720 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1127134000721 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1127134000722 tetramer interface [polypeptide binding]; other site 1127134000723 heme binding pocket [chemical binding]; other site 1127134000724 NADPH binding site [chemical binding]; other site 1127134000725 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1127134000726 gating phenylalanine in ion channel; other site 1127134000727 hypothetical protein; Provisional; Region: PRK07588 1127134000728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134000729 Helix-turn-helix domains; Region: HTH; cl00088 1127134000730 allophanate hydrolase; Provisional; Region: PRK08186 1127134000731 Amidase; Region: Amidase; cl11426 1127134000732 urea carboxylase; Region: urea_carbox; TIGR02712 1127134000733 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127134000734 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134000735 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1127134000736 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1127134000737 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1127134000738 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1127134000739 carboxyltransferase (CT) interaction site; other site 1127134000740 biotinylation site [posttranslational modification]; other site 1127134000741 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1127134000742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134000743 DNA-binding site [nucleotide binding]; DNA binding site 1127134000744 FCD domain; Region: FCD; cl11656 1127134000745 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134000746 Retinoic acid induced 16-like protein; Region: RAI16-like; pfam10257 1127134000747 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1127134000748 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1127134000749 putative active site [active] 1127134000750 putative metal binding site [ion binding]; other site 1127134000751 GatB domain; Region: GatB_Yqey; cl11497 1127134000752 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1127134000753 Transglycosylase; Region: Transgly; cl07896 1127134000754 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134000755 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1127134000756 Transcription factor WhiB; Region: Whib; pfam02467 1127134000757 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1127134000758 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1127134000759 P loop; other site 1127134000760 Nucleotide binding site [chemical binding]; other site 1127134000761 DTAP/Switch II; other site 1127134000762 Switch I; other site 1127134000763 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134000764 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1127134000765 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1127134000766 P loop; other site 1127134000767 Nucleotide binding site [chemical binding]; other site 1127134000768 DTAP/Switch II; other site 1127134000769 Switch I; other site 1127134000770 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1127134000771 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1127134000772 homotrimer interaction site [polypeptide binding]; other site 1127134000773 putative active site [active] 1127134000774 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134000775 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1127134000776 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1127134000777 ligand binding site [chemical binding]; other site 1127134000778 flexible hinge region; other site 1127134000779 Helix-turn-helix domains; Region: HTH; cl00088 1127134000780 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1127134000781 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1127134000782 minor groove reading motif; other site 1127134000783 helix-hairpin-helix signature motif; other site 1127134000784 substrate binding pocket [chemical binding]; other site 1127134000785 active site 1127134000786 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1127134000787 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1127134000788 catalytic residues [active] 1127134000789 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1127134000790 putative active site [active] 1127134000791 putative CoA binding site [chemical binding]; other site 1127134000792 nudix motif; other site 1127134000793 metal binding site [ion binding]; metal-binding site 1127134000794 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1127134000795 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134000796 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134000797 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 1127134000798 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1127134000799 acetyl-CoA synthetase; Provisional; Region: PRK00174 1127134000800 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1127134000801 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134000802 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134000803 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134000804 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1127134000805 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1127134000806 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1127134000807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134000808 dimer interface [polypeptide binding]; other site 1127134000809 conserved gate region; other site 1127134000810 putative PBP binding loops; other site 1127134000811 ABC-ATPase subunit interface; other site 1127134000812 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1127134000813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134000814 dimer interface [polypeptide binding]; other site 1127134000815 conserved gate region; other site 1127134000816 putative PBP binding loops; other site 1127134000817 ABC-ATPase subunit interface; other site 1127134000818 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1127134000819 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1127134000820 Walker A/P-loop; other site 1127134000821 ATP binding site [chemical binding]; other site 1127134000822 Q-loop/lid; other site 1127134000823 ABC transporter signature motif; other site 1127134000824 Walker B; other site 1127134000825 D-loop; other site 1127134000826 H-loop/switch region; other site 1127134000827 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1127134000828 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1127134000829 Walker A/P-loop; other site 1127134000830 ATP binding site [chemical binding]; other site 1127134000831 Q-loop/lid; other site 1127134000832 ABC transporter signature motif; other site 1127134000833 Walker B; other site 1127134000834 D-loop; other site 1127134000835 H-loop/switch region; other site 1127134000836 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1127134000837 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1127134000838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134000839 motif II; other site 1127134000840 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1127134000841 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 1127134000842 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134000843 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134000844 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1127134000845 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 1127134000846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134000847 sequence-specific DNA binding site [nucleotide binding]; other site 1127134000848 salt bridge; other site 1127134000849 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1127134000850 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1127134000851 catalytic residues [active] 1127134000852 Recombinase; Region: Recombinase; pfam07508 1127134000853 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1127134000854 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1127134000855 hexamer interface [polypeptide binding]; other site 1127134000856 Walker B motif; other site 1127134000857 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1127134000858 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1127134000859 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134000860 ATP binding site [chemical binding]; other site 1127134000861 putative Mg++ binding site [ion binding]; other site 1127134000862 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134000863 nucleotide binding region [chemical binding]; other site 1127134000864 ATP-binding site [chemical binding]; other site 1127134000865 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1127134000866 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1127134000867 DNA-binding site [nucleotide binding]; DNA binding site 1127134000868 RNA-binding motif; other site 1127134000869 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1127134000870 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1127134000871 active site 1127134000872 interdomain interaction site; other site 1127134000873 putative metal-binding site [ion binding]; other site 1127134000874 nucleotide binding site [chemical binding]; other site 1127134000875 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1127134000876 domain I; other site 1127134000877 phosphate binding site [ion binding]; other site 1127134000878 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1127134000879 domain II; other site 1127134000880 domain III; other site 1127134000881 nucleotide binding site [chemical binding]; other site 1127134000882 DNA binding groove [nucleotide binding] 1127134000883 catalytic site [active] 1127134000884 domain IV; other site 1127134000885 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1127134000886 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1127134000887 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1127134000888 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1127134000889 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1127134000890 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134000891 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134000892 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1127134000893 active site 1127134000894 DNA binding site [nucleotide binding] 1127134000895 Int/Topo IB signature motif; other site 1127134000896 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134000897 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134000898 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1127134000899 polymerase nucleotide-binding site; other site 1127134000900 DNA-binding residues [nucleotide binding]; DNA binding site 1127134000901 nucleotide binding site [chemical binding]; other site 1127134000902 primase nucleotide-binding site [nucleotide binding]; other site 1127134000903 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 1127134000904 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134000905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134000906 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1127134000907 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1127134000908 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134000909 putative metal binding site [ion binding]; other site 1127134000910 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134000911 dimerization interface [polypeptide binding]; other site 1127134000912 putative DNA binding site [nucleotide binding]; other site 1127134000913 putative Zn2+ binding site [ion binding]; other site 1127134000914 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134000915 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1127134000916 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1127134000917 Peptidase family M1; Region: Peptidase_M1; pfam01433 1127134000918 Zn binding site [ion binding]; other site 1127134000919 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1127134000920 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134000921 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134000922 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1127134000923 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1127134000924 putative trimer interface [polypeptide binding]; other site 1127134000925 putative CoA binding site [chemical binding]; other site 1127134000926 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1127134000927 putative trimer interface [polypeptide binding]; other site 1127134000928 putative CoA binding site [chemical binding]; other site 1127134000929 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1127134000930 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134000931 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134000932 catalytic residue [active] 1127134000933 Flavin Reductases; Region: FlaRed; cl00801 1127134000934 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1127134000935 putative deacylase active site [active] 1127134000936 enoyl-CoA hydratase; Provisional; Region: PRK06142 1127134000937 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134000938 substrate binding site [chemical binding]; other site 1127134000939 oxyanion hole (OAH) forming residues; other site 1127134000940 trimer interface [polypeptide binding]; other site 1127134000941 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1127134000942 dimer interface [polypeptide binding]; other site 1127134000943 substrate binding site [chemical binding]; other site 1127134000944 metal binding sites [ion binding]; metal-binding site 1127134000945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134000946 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1127134000947 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 1127134000948 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1127134000949 Ligand Binding Site [chemical binding]; other site 1127134000950 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127134000951 active site 1127134000952 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134000953 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134000954 active site 1127134000955 ATP binding site [chemical binding]; other site 1127134000956 substrate binding site [chemical binding]; other site 1127134000957 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134000958 substrate binding site [chemical binding]; other site 1127134000959 activation loop (A-loop); other site 1127134000960 activation loop (A-loop); other site 1127134000961 amidase; Provisional; Region: PRK06061 1127134000962 Amidase; Region: Amidase; cl11426 1127134000963 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1127134000964 Helix-turn-helix domains; Region: HTH; cl00088 1127134000965 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1127134000966 dimerization interface [polypeptide binding]; other site 1127134000967 substrate binding pocket [chemical binding]; other site 1127134000968 short chain dehydrogenase; Provisional; Region: PRK07825 1127134000969 classical (c) SDRs; Region: SDR_c; cd05233 1127134000970 NAD(P) binding site [chemical binding]; other site 1127134000971 active site 1127134000972 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134000973 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1127134000974 NAD(P) binding site [chemical binding]; other site 1127134000975 catalytic residues [active] 1127134000976 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1127134000977 Helix-turn-helix domains; Region: HTH; cl00088 1127134000978 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 1127134000979 Protein of unknown function (DUF1266); Region: DUF1266; cl14673 1127134000980 FtsH Extracellular; Region: FtsH_ext; pfam06480 1127134000981 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1127134000982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134000983 Walker A motif; other site 1127134000984 ATP binding site [chemical binding]; other site 1127134000985 Walker B motif; other site 1127134000986 arginine finger; other site 1127134000987 Peptidase family M41; Region: Peptidase_M41; pfam01434 1127134000988 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1127134000989 homodecamer interface [polypeptide binding]; other site 1127134000990 GTP cyclohydrolase I; Provisional; Region: PLN03044 1127134000991 active site 1127134000992 putative catalytic site residues [active] 1127134000993 zinc binding site [ion binding]; other site 1127134000994 GTP-CH-I/GFRP interaction surface; other site 1127134000995 dihydropteroate synthase; Region: DHPS; TIGR01496 1127134000996 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1127134000997 substrate binding pocket [chemical binding]; other site 1127134000998 dimer interface [polypeptide binding]; other site 1127134000999 inhibitor binding site; inhibition site 1127134001000 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1127134001001 homooctamer interface [polypeptide binding]; other site 1127134001002 active site 1127134001003 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1127134001004 catalytic center binding site [active] 1127134001005 ATP binding site [chemical binding]; other site 1127134001006 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1127134001007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134001008 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1127134001009 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1127134001010 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1127134001011 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1127134001012 active site 1127134001013 ATP-binding site [chemical binding]; other site 1127134001014 pantoate-binding site; other site 1127134001015 HXXH motif; other site 1127134001016 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1127134001017 tetramerization interface [polypeptide binding]; other site 1127134001018 active site 1127134001019 Type III pantothenate kinase; Region: Pan_kinase; cl09130 1127134001020 Cysteine dioxygenase type I; Region: CDO_I; cl15835 1127134001021 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1127134001022 active site residue [active] 1127134001023 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1127134001024 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1127134001025 dimer interface [polypeptide binding]; other site 1127134001026 putative anticodon binding site; other site 1127134001027 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1127134001028 motif 1; other site 1127134001029 dimer interface [polypeptide binding]; other site 1127134001030 active site 1127134001031 motif 2; other site 1127134001032 motif 3; other site 1127134001033 Lsr2; Region: Lsr2; pfam11774 1127134001034 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1127134001035 phosphopeptide binding site; other site 1127134001036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134001037 DNA binding residues [nucleotide binding] 1127134001038 dimerization interface [polypeptide binding]; other site 1127134001039 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1127134001040 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1127134001041 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134001042 Clp protease ATP binding subunit; Region: clpC; CHL00095 1127134001043 Clp amino terminal domain; Region: Clp_N; pfam02861 1127134001044 Clp amino terminal domain; Region: Clp_N; pfam02861 1127134001045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134001046 Walker A motif; other site 1127134001047 ATP binding site [chemical binding]; other site 1127134001048 Walker B motif; other site 1127134001049 arginine finger; other site 1127134001050 UvrB/uvrC motif; Region: UVR; pfam02151 1127134001051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134001052 Walker A motif; other site 1127134001053 ATP binding site [chemical binding]; other site 1127134001054 Walker B motif; other site 1127134001055 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1127134001056 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1127134001057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134001058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134001059 active site 1127134001060 phosphorylation site [posttranslational modification] 1127134001061 intermolecular recognition site; other site 1127134001062 dimerization interface [polypeptide binding]; other site 1127134001063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134001064 DNA binding residues [nucleotide binding] 1127134001065 dimerization interface [polypeptide binding]; other site 1127134001066 TraX protein; Region: TraX; cl05434 1127134001067 Histidine kinase; Region: HisKA_3; pfam07730 1127134001068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1127134001069 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127134001070 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 1127134001071 Walker A/P-loop; other site 1127134001072 ATP binding site [chemical binding]; other site 1127134001073 Q-loop/lid; other site 1127134001074 ABC transporter signature motif; other site 1127134001075 Walker B; other site 1127134001076 D-loop; other site 1127134001077 H-loop/switch region; other site 1127134001078 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1127134001079 putative hydrophobic ligand binding site [chemical binding]; other site 1127134001080 OsmC-like protein; Region: OsmC; cl00767 1127134001081 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1127134001082 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1127134001083 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134001084 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134001085 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1127134001086 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1127134001087 minor groove reading motif; other site 1127134001088 helix-hairpin-helix signature motif; other site 1127134001089 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1127134001090 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1127134001091 active site clefts [active] 1127134001092 zinc binding site [ion binding]; other site 1127134001093 dimer interface [polypeptide binding]; other site 1127134001094 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1127134001095 DNA repair protein RadA; Provisional; Region: PRK11823 1127134001096 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134001097 Walker A motif; other site 1127134001098 ATP binding site [chemical binding]; other site 1127134001099 Walker B motif; other site 1127134001100 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1127134001101 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1127134001102 substrate binding site; other site 1127134001103 dimer interface; other site 1127134001104 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1127134001105 homotrimer interaction site [polypeptide binding]; other site 1127134001106 zinc binding site [ion binding]; other site 1127134001107 CDP-binding sites; other site 1127134001108 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1127134001109 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1127134001110 active site 1127134001111 HIGH motif; other site 1127134001112 nucleotide binding site [chemical binding]; other site 1127134001113 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1127134001114 KMSKS motif; other site 1127134001115 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1127134001116 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1127134001117 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1127134001118 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1127134001119 enoyl-CoA hydratase; Provisional; Region: PRK08260 1127134001120 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134001121 substrate binding site [chemical binding]; other site 1127134001122 oxyanion hole (OAH) forming residues; other site 1127134001123 trimer interface [polypeptide binding]; other site 1127134001124 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134001125 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1127134001126 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1127134001127 active site 1127134001128 Helix-turn-helix domains; Region: HTH; cl00088 1127134001129 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 1127134001130 dimer interface [polypeptide binding]; other site 1127134001131 FMN binding site [chemical binding]; other site 1127134001132 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1127134001133 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1127134001134 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134001135 Walker A/P-loop; other site 1127134001136 ATP binding site [chemical binding]; other site 1127134001137 Q-loop/lid; other site 1127134001138 ABC transporter signature motif; other site 1127134001139 Walker B; other site 1127134001140 D-loop; other site 1127134001141 H-loop/switch region; other site 1127134001142 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1127134001143 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1127134001144 intersubunit interface [polypeptide binding]; other site 1127134001145 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1127134001146 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1127134001147 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1127134001148 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1127134001149 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134001150 Helix-turn-helix domains; Region: HTH; cl00088 1127134001151 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1127134001152 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134001153 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134001154 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134001155 active site 1127134001156 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134001157 active site 1127134001158 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134001159 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134001160 active site 1127134001161 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134001162 DUF35 OB-fold domain; Region: DUF35; pfam01796 1127134001163 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1127134001164 putative active site [active] 1127134001165 putative catalytic site [active] 1127134001166 lipid-transfer protein; Provisional; Region: PRK07855 1127134001167 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1127134001168 active site 1127134001169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1127134001170 Helix-turn-helix domains; Region: HTH; cl00088 1127134001171 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1127134001172 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1127134001173 MoxR-like ATPases [General function prediction only]; Region: COG0714 1127134001174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134001175 Walker A motif; other site 1127134001176 ATP binding site [chemical binding]; other site 1127134001177 Walker B motif; other site 1127134001178 arginine finger; other site 1127134001179 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1127134001180 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1127134001181 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1127134001182 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1127134001183 putative active site [active] 1127134001184 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1127134001185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1127134001186 Cupin domain; Region: Cupin_2; cl09118 1127134001187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134001188 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127134001189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134001190 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1127134001191 EspG family; Region: ESX-1_EspG; pfam14011 1127134001192 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134001193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134001194 non-specific DNA binding site [nucleotide binding]; other site 1127134001195 salt bridge; other site 1127134001196 sequence-specific DNA binding site [nucleotide binding]; other site 1127134001197 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 1127134001198 enoyl-CoA hydratase; Region: PLN02864 1127134001199 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134001200 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1127134001201 dimer interaction site [polypeptide binding]; other site 1127134001202 substrate-binding tunnel; other site 1127134001203 active site 1127134001204 catalytic site [active] 1127134001205 substrate binding site [chemical binding]; other site 1127134001206 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1127134001207 hypothetical protein; Validated; Region: PRK07121 1127134001208 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1127134001209 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1127134001210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134001211 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1127134001212 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1127134001213 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1127134001214 active site 1127134001215 catalytic residues [active] 1127134001216 metal binding site [ion binding]; metal-binding site 1127134001217 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1127134001218 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1127134001219 putative active site [active] 1127134001220 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 1127134001221 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 1127134001222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1127134001223 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1127134001224 Flavin Reductases; Region: FlaRed; cl00801 1127134001225 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1127134001226 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1127134001227 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1127134001228 active site 1127134001229 Fe binding site [ion binding]; other site 1127134001230 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1127134001231 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134001232 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134001233 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1127134001234 Flavin binding site [chemical binding]; other site 1127134001235 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1127134001236 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1127134001237 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134001238 hydrophobic ligand binding site; other site 1127134001239 Domain of unknown function (DUF427); Region: DUF427; cl00998 1127134001240 Domain of unknown function (DUF427); Region: DUF427; cl00998 1127134001241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134001242 putative substrate translocation pore; other site 1127134001243 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127134001244 Helix-turn-helix domains; Region: HTH; cl00088 1127134001245 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1127134001246 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134001247 active site 1127134001248 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1127134001249 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134001250 active site 1127134001251 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134001252 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134001253 active site 1127134001254 enoyl-CoA hydratase; Provisional; Region: PRK08290 1127134001255 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134001256 substrate binding site [chemical binding]; other site 1127134001257 oxyanion hole (OAH) forming residues; other site 1127134001258 trimer interface [polypeptide binding]; other site 1127134001259 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1127134001260 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001261 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134001262 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1127134001263 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134001264 active site 1127134001265 short chain dehydrogenase; Provisional; Region: PRK07831 1127134001266 classical (c) SDRs; Region: SDR_c; cd05233 1127134001267 NAD(P) binding site [chemical binding]; other site 1127134001268 active site 1127134001269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134001270 Helix-turn-helix domains; Region: HTH; cl00088 1127134001271 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1127134001272 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1127134001273 dimer interface [polypeptide binding]; other site 1127134001274 active site 1127134001275 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1127134001276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134001277 Nitronate monooxygenase; Region: NMO; pfam03060 1127134001278 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1127134001279 FMN binding site [chemical binding]; other site 1127134001280 substrate binding site [chemical binding]; other site 1127134001281 putative catalytic residue [active] 1127134001282 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1127134001283 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1127134001284 enoyl-CoA hydratase; Provisional; Region: PRK06495 1127134001285 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134001286 substrate binding site [chemical binding]; other site 1127134001287 oxyanion hole (OAH) forming residues; other site 1127134001288 trimer interface [polypeptide binding]; other site 1127134001289 classical (c) SDRs; Region: SDR_c; cd05233 1127134001290 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1127134001291 NAD(P) binding site [chemical binding]; other site 1127134001292 active site 1127134001293 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1127134001294 NAD binding site [chemical binding]; other site 1127134001295 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 1127134001296 homodimer interface [polypeptide binding]; other site 1127134001297 active site 1127134001298 Domain of unknown function (DUF955); Region: DUF955; cl01076 1127134001299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134001300 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127134001301 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1127134001302 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1127134001303 dimer interface [polypeptide binding]; other site 1127134001304 active site 1127134001305 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134001306 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134001307 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134001308 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1127134001309 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1127134001310 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1127134001311 active site 1127134001312 lipid-transfer protein; Provisional; Region: PRK07937 1127134001313 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1127134001314 active site 1127134001315 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1127134001316 DUF35 OB-fold domain; Region: DUF35; pfam01796 1127134001317 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1127134001318 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1127134001319 DUF35 OB-fold domain; Region: DUF35; pfam01796 1127134001320 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1127134001321 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1127134001322 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001323 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1127134001324 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134001325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134001326 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134001327 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1127134001328 enoyl-CoA hydratase; Provisional; Region: PRK07799 1127134001329 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134001330 substrate binding site [chemical binding]; other site 1127134001331 oxyanion hole (OAH) forming residues; other site 1127134001332 trimer interface [polypeptide binding]; other site 1127134001333 acyl-CoA synthetase; Validated; Region: PRK07798 1127134001334 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001335 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134001336 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1127134001337 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1127134001338 active site 1127134001339 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134001340 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1127134001341 FAD binding site [chemical binding]; other site 1127134001342 substrate binding site [chemical binding]; other site 1127134001343 catalytic base [active] 1127134001344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134001345 NAD(P) binding site [chemical binding]; other site 1127134001346 active site 1127134001347 Permease; Region: Permease; cl00510 1127134001348 Permease; Region: Permease; cl00510 1127134001349 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134001350 mce related protein; Region: MCE; pfam02470 1127134001351 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1127134001352 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134001353 mce related protein; Region: MCE; pfam02470 1127134001354 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134001355 mce related protein; Region: MCE; pfam02470 1127134001356 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134001357 mce related protein; Region: MCE; pfam02470 1127134001358 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134001359 mce related protein; Region: MCE; pfam02470 1127134001360 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134001361 mce related protein; Region: MCE; pfam02470 1127134001362 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1127134001363 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1127134001364 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1127134001365 MULE transposase domain; Region: MULE; pfam10551 1127134001366 MbtH-like protein; Region: MbtH; cl01279 1127134001367 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134001368 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134001369 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1127134001370 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 1127134001371 active site 1127134001372 homotetramer interface [polypeptide binding]; other site 1127134001373 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127134001374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134001375 active site 1127134001376 phosphorylation site [posttranslational modification] 1127134001377 intermolecular recognition site; other site 1127134001378 dimerization interface [polypeptide binding]; other site 1127134001379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127134001380 DNA binding site [nucleotide binding] 1127134001381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127134001382 dimer interface [polypeptide binding]; other site 1127134001383 phosphorylation site [posttranslational modification] 1127134001384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134001385 ATP binding site [chemical binding]; other site 1127134001386 G-X-G motif; other site 1127134001387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134001388 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1127134001389 nucleotide binding site/active site [active] 1127134001390 HIT family signature motif; other site 1127134001391 catalytic residue [active] 1127134001392 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1127134001393 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1127134001394 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1127134001395 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134001396 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1127134001397 Peptidase family M23; Region: Peptidase_M23; pfam01551 1127134001398 aspartate aminotransferase; Provisional; Region: PRK05764 1127134001399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127134001400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134001401 homodimer interface [polypeptide binding]; other site 1127134001402 catalytic residue [active] 1127134001403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1127134001404 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1127134001405 tetramer interface [polypeptide binding]; other site 1127134001406 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1127134001407 HIT family signature motif; other site 1127134001408 catalytic residue [active] 1127134001409 Putative esterase; Region: Esterase; pfam00756 1127134001410 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134001411 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1127134001412 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134001413 Predicted deacetylase [General function prediction only]; Region: COG3233 1127134001414 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1127134001415 putative active site [active] 1127134001416 putative Zn binding site [ion binding]; other site 1127134001417 hypothetical protein; Provisional; Region: PRK07907 1127134001418 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1127134001419 active site 1127134001420 metal binding site [ion binding]; metal-binding site 1127134001421 dimer interface [polypeptide binding]; other site 1127134001422 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134001423 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1127134001424 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1127134001425 putative active site [active] 1127134001426 catalytic triad [active] 1127134001427 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1127134001428 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1127134001429 active site 1127134001430 metal binding site [ion binding]; metal-binding site 1127134001431 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1127134001432 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1127134001433 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1127134001434 dimerization interface [polypeptide binding]; other site 1127134001435 ATP binding site [chemical binding]; other site 1127134001436 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1127134001437 dimerization interface [polypeptide binding]; other site 1127134001438 ATP binding site [chemical binding]; other site 1127134001439 yiaA/B two helix domain; Region: YiaAB; cl01759 1127134001440 Predicted membrane protein [Function unknown]; Region: COG4425 1127134001441 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1127134001442 CAAX protease self-immunity; Region: Abi; cl00558 1127134001443 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1127134001444 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1127134001445 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134001446 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1127134001447 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1127134001448 active site 1127134001449 tetramer interface [polypeptide binding]; other site 1127134001450 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127134001451 active site 1127134001452 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1127134001453 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1127134001454 dimerization interface [polypeptide binding]; other site 1127134001455 putative ATP binding site [chemical binding]; other site 1127134001456 L-asparaginase II; Region: Asparaginase_II; cl01842 1127134001457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1127134001458 MOSC domain; Region: MOSC; pfam03473 1127134001459 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1127134001460 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1127134001461 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1127134001462 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1127134001463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134001464 catalytic residue [active] 1127134001465 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1127134001466 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1127134001467 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1127134001468 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1127134001469 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1127134001470 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134001471 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1127134001472 Walker A/P-loop; other site 1127134001473 ATP binding site [chemical binding]; other site 1127134001474 Q-loop/lid; other site 1127134001475 ABC transporter signature motif; other site 1127134001476 Walker B; other site 1127134001477 D-loop; other site 1127134001478 H-loop/switch region; other site 1127134001479 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1127134001480 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134001481 Walker A/P-loop; other site 1127134001482 ATP binding site [chemical binding]; other site 1127134001483 ABC transporter signature motif; other site 1127134001484 Walker B; other site 1127134001485 D-loop; other site 1127134001486 H-loop/switch region; other site 1127134001487 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1127134001488 heme-binding site [chemical binding]; other site 1127134001489 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1127134001490 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1127134001491 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1127134001492 active site residue [active] 1127134001493 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1127134001494 active site residue [active] 1127134001495 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1127134001496 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1127134001497 catalytic residues [active] 1127134001498 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1127134001499 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127134001500 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127134001501 DNA binding site [nucleotide binding] 1127134001502 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1127134001503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134001504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134001505 dimer interface [polypeptide binding]; other site 1127134001506 conserved gate region; other site 1127134001507 putative PBP binding loops; other site 1127134001508 ABC-ATPase subunit interface; other site 1127134001509 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1127134001510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134001511 dimer interface [polypeptide binding]; other site 1127134001512 conserved gate region; other site 1127134001513 putative PBP binding loops; other site 1127134001514 ABC-ATPase subunit interface; other site 1127134001515 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1127134001516 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1127134001517 Walker A/P-loop; other site 1127134001518 ATP binding site [chemical binding]; other site 1127134001519 Q-loop/lid; other site 1127134001520 ABC transporter signature motif; other site 1127134001521 Walker B; other site 1127134001522 D-loop; other site 1127134001523 H-loop/switch region; other site 1127134001524 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1127134001525 PhoU domain; Region: PhoU; pfam01895 1127134001526 PhoU domain; Region: PhoU; pfam01895 1127134001527 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1127134001528 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1127134001529 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1127134001530 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1127134001531 FMN binding site [chemical binding]; other site 1127134001532 active site 1127134001533 catalytic residues [active] 1127134001534 substrate binding site [chemical binding]; other site 1127134001535 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1127134001536 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1127134001537 homodimer interface [polypeptide binding]; other site 1127134001538 putative substrate binding pocket [chemical binding]; other site 1127134001539 diiron center [ion binding]; other site 1127134001540 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1127134001541 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1127134001542 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1127134001543 Ligand binding site; other site 1127134001544 Putative Catalytic site; other site 1127134001545 DXD motif; other site 1127134001546 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1127134001547 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1127134001548 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1127134001549 putative acyl-acceptor binding pocket; other site 1127134001550 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1127134001551 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1127134001552 putative acyl-acceptor binding pocket; other site 1127134001553 salicylate synthase MbtI; Reviewed; Region: PRK07912 1127134001554 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1127134001555 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1127134001556 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001557 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001558 short chain dehydrogenase; Provisional; Region: PRK06197 1127134001559 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1127134001560 putative NAD(P) binding site [chemical binding]; other site 1127134001561 active site 1127134001562 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1127134001563 NeuB family; Region: NeuB; cl00496 1127134001564 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1127134001565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134001566 S-adenosylmethionine binding site [chemical binding]; other site 1127134001567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1127134001568 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134001569 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1127134001570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134001571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134001572 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134001573 aminotransferase; Validated; Region: PRK07777 1127134001574 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127134001575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134001576 homodimer interface [polypeptide binding]; other site 1127134001577 catalytic residue [active] 1127134001578 LysE type translocator; Region: LysE; cl00565 1127134001579 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1127134001580 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1127134001581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134001582 ATP binding site [chemical binding]; other site 1127134001583 putative Mg++ binding site [ion binding]; other site 1127134001584 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134001585 nucleotide binding region [chemical binding]; other site 1127134001586 ATP-binding site [chemical binding]; other site 1127134001587 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1127134001588 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1127134001589 Zn binding site [ion binding]; other site 1127134001590 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1127134001591 WYL domain; Region: WYL; cl14852 1127134001592 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1127134001593 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1127134001594 DNA-binding site [nucleotide binding]; DNA binding site 1127134001595 RNA-binding motif; other site 1127134001596 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1127134001597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1127134001598 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1127134001599 Probable transposase; Region: OrfB_IS605; pfam01385 1127134001600 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1127134001601 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1127134001602 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1127134001603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134001604 Helix-turn-helix domains; Region: HTH; cl00088 1127134001605 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1127134001606 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1127134001607 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127134001608 Helix-turn-helix domains; Region: HTH; cl00088 1127134001609 hypothetical protein; Provisional; Region: PRK11770 1127134001610 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1127134001611 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1127134001612 hypothetical protein; Provisional; Region: PRK01346 1127134001613 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134001614 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1127134001615 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1127134001616 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1127134001617 Helix-turn-helix domain; Region: HTH_18; pfam12833 1127134001618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134001619 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134001620 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1127134001621 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134001622 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1127134001623 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134001624 catalytic residue [active] 1127134001625 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1127134001626 Citrate synthase; Region: Citrate_synt; pfam00285 1127134001627 oxalacetate binding site [chemical binding]; other site 1127134001628 citrylCoA binding site [chemical binding]; other site 1127134001629 coenzyme A binding site [chemical binding]; other site 1127134001630 catalytic triad [active] 1127134001631 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1127134001632 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134001633 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1127134001634 H+ Antiporter protein; Region: 2A0121; TIGR00900 1127134001635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134001636 putative substrate translocation pore; other site 1127134001637 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1127134001638 dimer interface [polypeptide binding]; other site 1127134001639 Citrate synthase; Region: Citrate_synt; pfam00285 1127134001640 active site 1127134001641 citrylCoA binding site [chemical binding]; other site 1127134001642 NADH binding [chemical binding]; other site 1127134001643 cationic pore residues; other site 1127134001644 oxalacetate/citrate binding site [chemical binding]; other site 1127134001645 coenzyme A binding site [chemical binding]; other site 1127134001646 catalytic triad [active] 1127134001647 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1127134001648 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134001649 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1127134001650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134001651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134001652 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134001653 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1127134001654 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1127134001655 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1127134001656 sensory histidine kinase CreC; Provisional; Region: PRK11100 1127134001657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127134001658 dimer interface [polypeptide binding]; other site 1127134001659 phosphorylation site [posttranslational modification] 1127134001660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134001661 Mg2+ binding site [ion binding]; other site 1127134001662 G-X-G motif; other site 1127134001663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134001664 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127134001665 active site 1127134001666 phosphorylation site [posttranslational modification] 1127134001667 intermolecular recognition site; other site 1127134001668 dimerization interface [polypeptide binding]; other site 1127134001669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127134001670 DNA binding site [nucleotide binding] 1127134001671 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1127134001672 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1127134001673 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001674 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134001675 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127134001676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134001677 ATP binding site [chemical binding]; other site 1127134001678 Mg2+ binding site [ion binding]; other site 1127134001679 G-X-G motif; other site 1127134001680 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1127134001681 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1127134001682 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1127134001683 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1127134001684 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1127134001685 G1 box; other site 1127134001686 GTP/Mg2+ binding site [chemical binding]; other site 1127134001687 G2 box; other site 1127134001688 Switch I region; other site 1127134001689 G3 box; other site 1127134001690 Switch II region; other site 1127134001691 G4 box; other site 1127134001692 G5 box; other site 1127134001693 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 1127134001694 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134001695 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134001696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134001697 sequence-specific DNA binding site [nucleotide binding]; other site 1127134001698 salt bridge; other site 1127134001699 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127134001700 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1127134001701 active site 1127134001702 catalytic tetrad [active] 1127134001703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134001704 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1127134001705 enoyl-CoA hydratase; Provisional; Region: PRK06688 1127134001706 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134001707 substrate binding site [chemical binding]; other site 1127134001708 oxyanion hole (OAH) forming residues; other site 1127134001709 trimer interface [polypeptide binding]; other site 1127134001710 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134001711 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1127134001712 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1127134001713 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1127134001714 nucleotide binding site [chemical binding]; other site 1127134001715 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 1127134001716 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1127134001717 active site 1127134001718 DNA binding site [nucleotide binding] 1127134001719 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1127134001720 DNA binding site [nucleotide binding] 1127134001721 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1127134001722 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1127134001723 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1127134001724 Cobalt transport protein; Region: CbiQ; cl00463 1127134001725 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1127134001726 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1127134001727 Walker A/P-loop; other site 1127134001728 ATP binding site [chemical binding]; other site 1127134001729 Q-loop/lid; other site 1127134001730 ABC transporter signature motif; other site 1127134001731 Walker B; other site 1127134001732 D-loop; other site 1127134001733 H-loop/switch region; other site 1127134001734 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1127134001735 Walker A/P-loop; other site 1127134001736 ATP binding site [chemical binding]; other site 1127134001737 Q-loop/lid; other site 1127134001738 ABC transporter signature motif; other site 1127134001739 Walker B; other site 1127134001740 D-loop; other site 1127134001741 H-loop/switch region; other site 1127134001742 Cation efflux family; Region: Cation_efflux; cl00316 1127134001743 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1127134001744 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127134001745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134001746 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134001747 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134001748 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1127134001749 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1127134001750 active site 1127134001751 metal binding site [ion binding]; metal-binding site 1127134001752 hexamer interface [polypeptide binding]; other site 1127134001753 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1127134001754 active site 1127134001755 cyclase homology domain; Region: CHD; cd07302 1127134001756 nucleotidyl binding site; other site 1127134001757 metal binding site [ion binding]; metal-binding site 1127134001758 dimer interface [polypeptide binding]; other site 1127134001759 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1127134001760 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134001761 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1127134001762 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 1127134001763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134001764 S-adenosylmethionine binding site [chemical binding]; other site 1127134001765 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1127134001766 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134001767 non-specific DNA binding site [nucleotide binding]; other site 1127134001768 salt bridge; other site 1127134001769 sequence-specific DNA binding site [nucleotide binding]; other site 1127134001770 Cupin domain; Region: Cupin_2; cl09118 1127134001771 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1127134001772 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1127134001773 dimer interface [polypeptide binding]; other site 1127134001774 active site 1127134001775 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1127134001776 Ligand Binding Site [chemical binding]; other site 1127134001777 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1127134001778 Ligand Binding Site [chemical binding]; other site 1127134001779 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 1127134001780 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1127134001781 Helix-turn-helix domains; Region: HTH; cl00088 1127134001782 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1127134001783 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1127134001784 NAD(P) binding site [chemical binding]; other site 1127134001785 catalytic residues [active] 1127134001786 choline dehydrogenase; Validated; Region: PRK02106 1127134001787 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1127134001788 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1127134001789 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1127134001790 BCCT family transporter; Region: BCCT; cl00569 1127134001791 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 1127134001792 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1127134001793 substrate binding pocket [chemical binding]; other site 1127134001794 membrane-bound complex binding site; other site 1127134001795 hinge residues; other site 1127134001796 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1127134001797 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134001798 Helix-turn-helix domain; Region: HTH_18; pfam12833 1127134001799 Cupin domain; Region: Cupin_2; cl09118 1127134001800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134001801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134001802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134001803 Helix-turn-helix domains; Region: HTH; cl00088 1127134001804 Bacterial transcriptional repressor; Region: TetR; pfam13972 1127134001805 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134001806 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127134001807 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134001808 non-specific DNA binding site [nucleotide binding]; other site 1127134001809 salt bridge; other site 1127134001810 sequence-specific DNA binding site [nucleotide binding]; other site 1127134001811 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1127134001812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134001813 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1127134001814 NAD(P) binding site [chemical binding]; other site 1127134001815 active site 1127134001816 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134001817 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134001818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134001819 non-specific DNA binding site [nucleotide binding]; other site 1127134001820 salt bridge; other site 1127134001821 sequence-specific DNA binding site [nucleotide binding]; other site 1127134001822 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1127134001823 putative active site pocket [active] 1127134001824 cleavage site 1127134001825 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1127134001826 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134001827 DNA binding residues [nucleotide binding] 1127134001828 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134001829 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1127134001830 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001831 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1127134001832 Nitronate monooxygenase; Region: NMO; pfam03060 1127134001833 FMN binding site [chemical binding]; other site 1127134001834 substrate binding site [chemical binding]; other site 1127134001835 putative catalytic residue [active] 1127134001836 Peptidase family M23; Region: Peptidase_M23; pfam01551 1127134001837 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1127134001838 Helix-turn-helix domains; Region: HTH; cl00088 1127134001839 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1127134001840 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001841 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134001842 peptide synthase; Provisional; Region: PRK12467 1127134001843 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134001844 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001845 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134001846 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134001847 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134001848 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001849 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1127134001850 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001851 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001852 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134001853 peptide synthase; Provisional; Region: PRK12467 1127134001854 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134001855 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001856 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134001857 Condensation domain; Region: Condensation; pfam00668 1127134001858 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127134001859 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134001860 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001861 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1127134001862 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134001863 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1127134001864 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134001865 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001866 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001867 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134001868 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1127134001869 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001870 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134001871 peptide synthase; Provisional; Region: PRK12316 1127134001872 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134001873 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001874 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134001875 peptide synthase; Provisional; Region: PRK12467 1127134001876 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134001877 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001878 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134001879 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134001880 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001881 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1127134001882 peptide synthase; Provisional; Region: PRK12467 1127134001883 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134001884 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134001885 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1127134001886 Predicted esterase [General function prediction only]; Region: COG0627 1127134001887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134001888 NAD(P) binding site [chemical binding]; other site 1127134001889 active site 1127134001890 enoyl-CoA hydratase; Provisional; Region: PRK06688 1127134001891 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134001892 substrate binding site [chemical binding]; other site 1127134001893 oxyanion hole (OAH) forming residues; other site 1127134001894 trimer interface [polypeptide binding]; other site 1127134001895 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1127134001896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134001897 Helix-turn-helix domains; Region: HTH; cl00088 1127134001898 Helix-turn-helix domains; Region: HTH; cl00088 1127134001899 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134001900 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1127134001901 NAD(P) binding site [chemical binding]; other site 1127134001902 catalytic residues [active] 1127134001903 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134001904 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1127134001905 Walker A/P-loop; other site 1127134001906 ATP binding site [chemical binding]; other site 1127134001907 Q-loop/lid; other site 1127134001908 ABC transporter signature motif; other site 1127134001909 Walker B; other site 1127134001910 D-loop; other site 1127134001911 H-loop/switch region; other site 1127134001912 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134001913 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134001914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134001915 Predicted esterase [General function prediction only]; Region: COG0627 1127134001916 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134001917 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1127134001918 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134001919 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134001920 CoenzymeA binding site [chemical binding]; other site 1127134001921 subunit interaction site [polypeptide binding]; other site 1127134001922 PHB binding site; other site 1127134001923 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 1127134001924 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 1127134001925 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1127134001926 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 1127134001927 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1127134001928 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1127134001929 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1127134001930 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 1127134001931 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1127134001932 putative translocon binding site; other site 1127134001933 protein-rRNA interface [nucleotide binding]; other site 1127134001934 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1127134001935 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1127134001936 G-X-X-G motif; other site 1127134001937 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1127134001938 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1127134001939 23S rRNA interface [nucleotide binding]; other site 1127134001940 5S rRNA interface [nucleotide binding]; other site 1127134001941 putative antibiotic binding site [chemical binding]; other site 1127134001942 L25 interface [polypeptide binding]; other site 1127134001943 L27 interface [polypeptide binding]; other site 1127134001944 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1127134001945 23S rRNA interface [nucleotide binding]; other site 1127134001946 putative translocon interaction site; other site 1127134001947 signal recognition particle (SRP54) interaction site; other site 1127134001948 L23 interface [polypeptide binding]; other site 1127134001949 trigger factor interaction site; other site 1127134001950 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 1127134001951 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134001952 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1127134001953 CAAX protease self-immunity; Region: Abi; cl00558 1127134001954 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1127134001955 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1127134001956 probable active site [active] 1127134001957 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134001958 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127134001959 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1127134001960 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134001961 Walker A/P-loop; other site 1127134001962 ATP binding site [chemical binding]; other site 1127134001963 Q-loop/lid; other site 1127134001964 ABC transporter signature motif; other site 1127134001965 Walker B; other site 1127134001966 D-loop; other site 1127134001967 H-loop/switch region; other site 1127134001968 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1127134001969 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134001970 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1127134001971 Walker A/P-loop; other site 1127134001972 ATP binding site [chemical binding]; other site 1127134001973 Q-loop/lid; other site 1127134001974 ABC transporter signature motif; other site 1127134001975 Walker B; other site 1127134001976 D-loop; other site 1127134001977 H-loop/switch region; other site 1127134001978 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134001979 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1127134001980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134001981 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1127134001982 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1127134001983 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1127134001984 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1127134001985 FAD binding pocket [chemical binding]; other site 1127134001986 FAD binding motif [chemical binding]; other site 1127134001987 phosphate binding motif [ion binding]; other site 1127134001988 NAD binding pocket [chemical binding]; other site 1127134001989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134001990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134001991 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 1127134001992 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1127134001993 active site 1127134001994 substrate binding site [chemical binding]; other site 1127134001995 cosubstrate binding site; other site 1127134001996 catalytic site [active] 1127134001997 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 1127134001998 peptide synthase; Provisional; Region: PRK12467 1127134001999 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134002000 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134002001 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134002002 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127134002003 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134002004 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1127134002005 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1127134002006 intersubunit interface [polypeptide binding]; other site 1127134002007 Condensation domain; Region: Condensation; pfam00668 1127134002008 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134002009 peptide synthase; Provisional; Region: PRK12467 1127134002010 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134002011 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134002012 Condensation domain; Region: Condensation; pfam00668 1127134002013 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134002014 Condensation domain; Region: Condensation; pfam00668 1127134002015 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127134002016 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1127134002017 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134002018 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134002019 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134002020 peptide synthase; Provisional; Region: PRK12467 1127134002021 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134002022 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134002023 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134002024 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1127134002025 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1127134002026 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127134002027 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1127134002028 active site 1127134002029 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1127134002030 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1127134002031 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1127134002032 short chain dehydrogenase; Provisional; Region: PRK12829 1127134002033 NADP binding site [chemical binding]; other site 1127134002034 active site 1127134002035 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134002036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134002037 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1127134002038 Walker A/P-loop; other site 1127134002039 ATP binding site [chemical binding]; other site 1127134002040 Q-loop/lid; other site 1127134002041 ABC transporter signature motif; other site 1127134002042 Walker B; other site 1127134002043 D-loop; other site 1127134002044 H-loop/switch region; other site 1127134002045 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134002046 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134002047 Domain of unknown function (DUF1971); Region: DUF1971; cl01451 1127134002048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134002049 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127134002050 putative substrate translocation pore; other site 1127134002051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134002052 Helix-turn-helix domains; Region: HTH; cl00088 1127134002053 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1127134002054 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1127134002055 putative active site [active] 1127134002056 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1127134002057 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1127134002058 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1127134002059 active site 1127134002060 Zn binding site [ion binding]; other site 1127134002061 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 1127134002062 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1127134002063 KOW motif; Region: KOW; cl00354 1127134002064 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1127134002065 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1127134002066 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1127134002067 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1127134002068 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1127134002069 putative active site [active] 1127134002070 Predicted ATPase [General function prediction only]; Region: COG3910 1127134002071 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134002072 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 1127134002073 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1127134002074 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1127134002075 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1127134002076 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1127134002077 5S rRNA interface [nucleotide binding]; other site 1127134002078 L27 interface [polypeptide binding]; other site 1127134002079 23S rRNA interface [nucleotide binding]; other site 1127134002080 L5 interface [polypeptide binding]; other site 1127134002081 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1127134002082 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1127134002083 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1127134002084 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1127134002085 23S rRNA binding site [nucleotide binding]; other site 1127134002086 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 1127134002087 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1127134002088 SecY translocase; Region: SecY; pfam00344 1127134002089 adenylate kinase; Reviewed; Region: adk; PRK00279 1127134002090 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1127134002091 AMP-binding site [chemical binding]; other site 1127134002092 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1127134002093 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1127134002094 active site 1127134002095 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1127134002096 dimerization interface [polypeptide binding]; other site 1127134002097 putative tRNAtyr binding site [nucleotide binding]; other site 1127134002098 putative active site [active] 1127134002099 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1127134002100 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1127134002101 EspG family; Region: ESX-1_EspG; pfam14011 1127134002102 PPE family; Region: PPE; pfam00823 1127134002103 EspG family; Region: ESX-1_EspG; pfam14011 1127134002104 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 1127134002105 Protein of unknown function (DUF690); Region: DUF690; cl04939 1127134002106 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1127134002107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134002108 Walker A motif; other site 1127134002109 ATP binding site [chemical binding]; other site 1127134002110 Walker B motif; other site 1127134002111 arginine finger; other site 1127134002112 Ubiquitin-like proteins; Region: UBQ; cl00155 1127134002113 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1127134002114 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1127134002115 active site 1127134002116 catalytic residues [active] 1127134002117 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1127134002118 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134002119 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1127134002120 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134002121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134002122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134002123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127134002124 Coenzyme A binding pocket [chemical binding]; other site 1127134002125 UTRA domain; Region: UTRA; cl01230 1127134002126 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1127134002127 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1127134002128 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1127134002129 rRNA binding site [nucleotide binding]; other site 1127134002130 predicted 30S ribosome binding site; other site 1127134002131 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1127134002132 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1127134002133 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1127134002134 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 1127134002135 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1127134002136 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1127134002137 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127134002138 RNA binding surface [nucleotide binding]; other site 1127134002139 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1127134002140 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1127134002141 alphaNTD - beta interaction site [polypeptide binding]; other site 1127134002142 alphaNTD homodimer interface [polypeptide binding]; other site 1127134002143 alphaNTD - beta' interaction site [polypeptide binding]; other site 1127134002144 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1127134002145 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 1127134002146 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1127134002147 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1127134002148 dimerization interface 3.5A [polypeptide binding]; other site 1127134002149 active site 1127134002151 Evidence 4 : Homologs of previously reported genes of unknown function 1127134002152 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1127134002153 putative dimer interface [polypeptide binding]; other site 1127134002154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134002155 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1127134002156 putative substrate translocation pore; other site 1127134002157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127134002158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134002159 active site 1127134002160 phosphorylation site [posttranslational modification] 1127134002161 intermolecular recognition site; other site 1127134002162 dimerization interface [polypeptide binding]; other site 1127134002163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127134002164 DNA binding site [nucleotide binding] 1127134002165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127134002166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134002167 ATP binding site [chemical binding]; other site 1127134002168 Mg2+ binding site [ion binding]; other site 1127134002169 G-X-G motif; other site 1127134002170 NMT1-like family; Region: NMT1_2; cl15260 1127134002171 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1127134002172 putative homodimer interface [polypeptide binding]; other site 1127134002173 putative homotetramer interface [polypeptide binding]; other site 1127134002174 putative allosteric switch controlling residues; other site 1127134002175 putative metal binding site [ion binding]; other site 1127134002176 putative homodimer-homodimer interface [polypeptide binding]; other site 1127134002177 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1127134002178 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134002179 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 1127134002180 Protein of unknown function (DUF690); Region: DUF690; cl04939 1127134002181 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1127134002182 active site 1127134002183 catalytic residues [active] 1127134002184 Ubiquitin-like proteins; Region: UBQ; cl00155 1127134002185 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1127134002186 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134002187 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1127134002188 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134002189 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134002190 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1127134002191 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1127134002192 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1127134002193 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134002194 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134002195 active site 1127134002196 ATP binding site [chemical binding]; other site 1127134002197 substrate binding site [chemical binding]; other site 1127134002198 activation loop (A-loop); other site 1127134002199 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134002200 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134002201 active site 1127134002202 ATP binding site [chemical binding]; other site 1127134002203 substrate binding site [chemical binding]; other site 1127134002204 activation loop (A-loop); other site 1127134002205 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1127134002206 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 1127134002207 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1127134002208 phosphopeptide binding site; other site 1127134002209 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1127134002210 phosphopeptide binding site; other site 1127134002211 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 1127134002212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1127134002213 Walker A/P-loop; other site 1127134002214 ATP binding site [chemical binding]; other site 1127134002215 Q-loop/lid; other site 1127134002216 ABC transporter signature motif; other site 1127134002217 Walker B; other site 1127134002218 D-loop; other site 1127134002219 H-loop/switch region; other site 1127134002220 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134002221 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1127134002222 23S rRNA interface [nucleotide binding]; other site 1127134002223 L3 interface [polypeptide binding]; other site 1127134002224 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 1127134002225 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1127134002226 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1127134002227 active site 1127134002228 substrate binding site [chemical binding]; other site 1127134002229 metal binding site [ion binding]; metal-binding site 1127134002230 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134002231 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134002232 active site 1127134002233 ATP binding site [chemical binding]; other site 1127134002234 substrate binding site [chemical binding]; other site 1127134002235 activation loop (A-loop); other site 1127134002236 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1127134002237 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134002238 Walker A/P-loop; other site 1127134002239 ATP binding site [chemical binding]; other site 1127134002240 Q-loop/lid; other site 1127134002241 ABC transporter signature motif; other site 1127134002242 Walker B; other site 1127134002243 D-loop; other site 1127134002244 H-loop/switch region; other site 1127134002245 ABC transporter; Region: ABC_tran_2; pfam12848 1127134002246 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1127134002247 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1127134002248 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1127134002249 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1127134002250 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1127134002251 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1127134002252 glutaminase active site [active] 1127134002253 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1127134002254 dimer interface [polypeptide binding]; other site 1127134002255 active site 1127134002256 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1127134002257 dimer interface [polypeptide binding]; other site 1127134002258 active site 1127134002259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134002260 putative substrate translocation pore; other site 1127134002261 Helix-turn-helix domains; Region: HTH; cl00088 1127134002262 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1127134002263 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1127134002264 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1127134002265 putative substrate binding site [chemical binding]; other site 1127134002266 putative ATP binding site [chemical binding]; other site 1127134002267 alanine racemase; Reviewed; Region: alr; PRK00053 1127134002268 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1127134002269 active site 1127134002270 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1127134002271 dimer interface [polypeptide binding]; other site 1127134002272 substrate binding site [chemical binding]; other site 1127134002273 catalytic residues [active] 1127134002274 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134002275 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134002276 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1127134002277 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1127134002278 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1127134002279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127134002280 Coenzyme A binding pocket [chemical binding]; other site 1127134002281 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134002282 UGMP family protein; Validated; Region: PRK09604 1127134002283 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1127134002284 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 1127134002285 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1127134002286 oligomerisation interface [polypeptide binding]; other site 1127134002287 mobile loop; other site 1127134002288 roof hairpin; other site 1127134002289 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1127134002290 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1127134002291 ring oligomerisation interface [polypeptide binding]; other site 1127134002292 ATP/Mg binding site [chemical binding]; other site 1127134002293 stacking interactions; other site 1127134002294 hinge regions; other site 1127134002295 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1127134002296 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134002297 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134002298 DNA binding residues [nucleotide binding] 1127134002299 Transcription factor WhiB; Region: Whib; pfam02467 1127134002300 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1127134002301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134002302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134002303 DNA binding residues [nucleotide binding] 1127134002304 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1127134002305 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1127134002306 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 1127134002307 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1127134002308 active site 1127134002309 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1127134002310 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1127134002311 active site 1127134002312 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134002313 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134002314 GMP synthase; Reviewed; Region: guaA; PRK00074 1127134002315 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1127134002316 AMP/PPi binding site [chemical binding]; other site 1127134002317 candidate oxyanion hole; other site 1127134002318 catalytic triad [active] 1127134002319 potential glutamine specificity residues [chemical binding]; other site 1127134002320 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1127134002321 ATP Binding subdomain [chemical binding]; other site 1127134002322 Ligand Binding sites [chemical binding]; other site 1127134002323 Dimerization subdomain; other site 1127134002324 PspC domain; Region: PspC; cl00864 1127134002325 PspC domain; Region: PspC; cl00864 1127134002326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127134002327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1127134002328 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134002329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134002330 active site 1127134002331 phosphorylation site [posttranslational modification] 1127134002332 intermolecular recognition site; other site 1127134002333 dimerization interface [polypeptide binding]; other site 1127134002334 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134002335 DNA binding residues [nucleotide binding] 1127134002336 dimerization interface [polypeptide binding]; other site 1127134002337 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134002338 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134002339 active site 1127134002340 ATP binding site [chemical binding]; other site 1127134002341 substrate binding site [chemical binding]; other site 1127134002342 activation loop (A-loop); other site 1127134002343 Y-family of DNA polymerases; Region: PolY; cl12025 1127134002344 active site 1127134002345 DNA binding site [nucleotide binding] 1127134002346 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134002347 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134002348 short chain dehydrogenase; Provisional; Region: PRK07109 1127134002349 classical (c) SDRs; Region: SDR_c; cd05233 1127134002350 NAD(P) binding site [chemical binding]; other site 1127134002351 active site 1127134002352 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1127134002353 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1127134002354 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1127134002355 generic binding surface II; other site 1127134002356 generic binding surface I; other site 1127134002357 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1127134002358 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1127134002359 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1127134002360 catalytic residues [active] 1127134002361 Recombinase; Region: Recombinase; pfam07508 1127134002362 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1127134002363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134002364 non-specific DNA binding site [nucleotide binding]; other site 1127134002365 salt bridge; other site 1127134002366 sequence-specific DNA binding site [nucleotide binding]; other site 1127134002367 Helix-turn-helix domains; Region: HTH; cl00088 1127134002368 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1127134002369 homotrimer interaction site [polypeptide binding]; other site 1127134002370 putative active site [active] 1127134002371 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1127134002372 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1127134002373 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134002374 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1127134002375 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1127134002376 homodimer interface [polypeptide binding]; other site 1127134002377 substrate-cofactor binding pocket; other site 1127134002378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134002379 catalytic residue [active] 1127134002380 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1127134002381 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134002382 Helix-turn-helix domains; Region: HTH; cl00088 1127134002383 lipid-transfer protein; Provisional; Region: PRK08256 1127134002384 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1127134002385 active site 1127134002386 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1127134002387 hydrophobic ligand binding site; other site 1127134002388 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1127134002389 active site 1127134002390 catalytic site [active] 1127134002391 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134002392 active site 2 [active] 1127134002393 active site 1 [active] 1127134002394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134002395 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1127134002396 NAD(P) binding site [chemical binding]; other site 1127134002397 active site 1127134002398 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134002399 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134002400 active site 1127134002401 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1127134002402 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1127134002403 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134002404 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134002405 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1127134002406 putative active site [active] 1127134002407 putative catalytic site [active] 1127134002408 putative DNA binding site [nucleotide binding]; other site 1127134002409 putative phosphate binding site [ion binding]; other site 1127134002410 metal binding site A [ion binding]; metal-binding site 1127134002411 putative AP binding site [nucleotide binding]; other site 1127134002412 putative metal binding site B [ion binding]; other site 1127134002413 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1127134002414 active site 1127134002415 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1127134002416 putative RNAase interaction site [polypeptide binding]; other site 1127134002417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134002418 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1127134002419 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1127134002420 active site 1127134002421 HIGH motif; other site 1127134002422 dimer interface [polypeptide binding]; other site 1127134002423 KMSKS motif; other site 1127134002424 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1127134002425 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1127134002426 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134002427 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1127134002428 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1127134002429 metal binding site [ion binding]; metal-binding site 1127134002430 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1127134002431 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 1127134002432 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127134002433 ABC-ATPase subunit interface; other site 1127134002434 dimer interface [polypeptide binding]; other site 1127134002435 putative PBP binding regions; other site 1127134002436 hypothetical protein; Reviewed; Region: PRK00024 1127134002437 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1127134002438 MPN+ (JAMM) motif; other site 1127134002439 Zinc-binding site [ion binding]; other site 1127134002440 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 1127134002441 cofactor binding site; other site 1127134002442 metal binding site [ion binding]; metal-binding site 1127134002443 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1127134002444 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 1127134002445 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1127134002446 putative active site [active] 1127134002447 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1127134002448 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1127134002449 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1127134002450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134002451 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1127134002452 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1127134002453 putative Iron-sulfur protein interface [polypeptide binding]; other site 1127134002454 putative proximal heme binding site [chemical binding]; other site 1127134002455 putative SdhC-like subunit interface [polypeptide binding]; other site 1127134002456 putative distal heme binding site [chemical binding]; other site 1127134002457 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1127134002458 putative Iron-sulfur protein interface [polypeptide binding]; other site 1127134002459 putative proximal heme binding site [chemical binding]; other site 1127134002460 putative SdhD-like interface [polypeptide binding]; other site 1127134002461 putative distal heme binding site [chemical binding]; other site 1127134002462 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 1127134002463 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1127134002464 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1127134002465 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1127134002466 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 1127134002467 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1127134002468 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127134002469 active site 1127134002470 NlpC/P60 family; Region: NLPC_P60; cl11438 1127134002471 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127134002472 active site 1127134002473 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1127134002474 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1127134002475 active site 1127134002476 substrate binding site [chemical binding]; other site 1127134002477 metal binding site [ion binding]; metal-binding site 1127134002478 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1127134002479 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134002480 substrate binding site [chemical binding]; other site 1127134002481 oxyanion hole (OAH) forming residues; other site 1127134002482 trimer interface [polypeptide binding]; other site 1127134002483 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1127134002484 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1127134002485 metal binding site [ion binding]; metal-binding site 1127134002486 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1127134002487 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1127134002488 metal binding site [ion binding]; metal-binding site 1127134002489 putative dimer interface [polypeptide binding]; other site 1127134002490 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1127134002491 putative active site pocket [active] 1127134002492 dimerization interface [polypeptide binding]; other site 1127134002493 putative catalytic residue [active] 1127134002494 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1127134002495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134002496 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134002497 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134002498 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1127134002499 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1127134002500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127134002501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134002502 homodimer interface [polypeptide binding]; other site 1127134002503 catalytic residue [active] 1127134002504 glycerol kinase; Provisional; Region: glpK; PRK00047 1127134002505 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1127134002506 N- and C-terminal domain interface [polypeptide binding]; other site 1127134002507 putative active site [active] 1127134002508 putative MgATP binding site [chemical binding]; other site 1127134002509 catalytic site [active] 1127134002510 metal binding site [ion binding]; metal-binding site 1127134002511 putative homotetramer interface [polypeptide binding]; other site 1127134002512 putative glycerol binding site [chemical binding]; other site 1127134002513 homodimer interface [polypeptide binding]; other site 1127134002514 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1127134002515 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134002516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134002517 Helix-turn-helix domains; Region: HTH; cl00088 1127134002518 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1127134002519 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1127134002520 putative DNA binding site [nucleotide binding]; other site 1127134002521 catalytic residue [active] 1127134002522 putative H2TH interface [polypeptide binding]; other site 1127134002523 putative catalytic residues [active] 1127134002524 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1127134002525 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1127134002526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134002527 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1127134002528 ATP binding site [chemical binding]; other site 1127134002529 putative Mg++ binding site [ion binding]; other site 1127134002530 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134002531 nucleotide binding region [chemical binding]; other site 1127134002532 ATP-binding site [chemical binding]; other site 1127134002533 DEAD/H associated; Region: DEAD_assoc; pfam08494 1127134002534 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1127134002535 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1127134002536 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1127134002537 short chain dehydrogenase; Provisional; Region: PRK07825 1127134002538 classical (c) SDRs; Region: SDR_c; cd05233 1127134002539 NAD(P) binding site [chemical binding]; other site 1127134002540 active site 1127134002541 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1127134002542 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134002543 tetrameric interface [polypeptide binding]; other site 1127134002544 NAD binding site [chemical binding]; other site 1127134002545 catalytic residues [active] 1127134002546 Helix-turn-helix domains; Region: HTH; cl00088 1127134002547 AsnC family; Region: AsnC_trans_reg; pfam01037 1127134002548 L-lysine aminotransferase; Provisional; Region: PRK08297 1127134002549 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127134002550 inhibitor-cofactor binding pocket; inhibition site 1127134002551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134002552 catalytic residue [active] 1127134002553 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1127134002554 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1127134002555 structural tetrad; other site 1127134002556 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1127134002557 active site 1127134002558 nucleophile elbow; other site 1127134002559 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1127134002560 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127134002561 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134002562 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1127134002563 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1127134002564 carboxyltransferase (CT) interaction site; other site 1127134002565 biotinylation site [posttranslational modification]; other site 1127134002566 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1127134002567 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1127134002568 active site residue [active] 1127134002569 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1127134002570 active site residue [active] 1127134002571 Predicted transcriptional regulator [Transcription]; Region: COG2345 1127134002572 Helix-turn-helix domains; Region: HTH; cl00088 1127134002573 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1127134002574 active site 1127134002575 dimer interface [polypeptide binding]; other site 1127134002576 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1127134002577 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1127134002578 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134002579 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134002580 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1127134002581 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1127134002582 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1127134002583 Bacterial PH domain; Region: DUF304; cl01348 1127134002584 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127134002585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134002586 active site 1127134002587 phosphorylation site [posttranslational modification] 1127134002588 intermolecular recognition site; other site 1127134002589 dimerization interface [polypeptide binding]; other site 1127134002590 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127134002591 DNA binding site [nucleotide binding] 1127134002592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1127134002593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134002594 ATP binding site [chemical binding]; other site 1127134002595 Mg2+ binding site [ion binding]; other site 1127134002596 G-X-G motif; other site 1127134002597 GtrA-like protein; Region: GtrA; cl00971 1127134002598 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1127134002599 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134002600 AIR carboxylase; Region: AIRC; cl00310 1127134002601 Helix-turn-helix domains; Region: HTH; cl00088 1127134002602 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134002603 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1127134002604 FAD binding site [chemical binding]; other site 1127134002605 homotetramer interface [polypeptide binding]; other site 1127134002606 substrate binding pocket [chemical binding]; other site 1127134002607 catalytic base [active] 1127134002608 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1127134002609 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134002610 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134002611 FAD binding domain; Region: FAD_binding_4; pfam01565 1127134002612 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1127134002613 GtrA-like protein; Region: GtrA; cl00971 1127134002614 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1127134002615 conserved cys residue [active] 1127134002616 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1127134002617 DinB superfamily; Region: DinB_2; pfam12867 1127134002618 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1127134002619 HIT family signature motif; other site 1127134002620 catalytic residue [active] 1127134002621 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1127134002622 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 1127134002623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134002624 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1127134002625 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1127134002626 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1127134002627 replication factor C subunit; Provisional; Region: PLN03025 1127134002628 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1127134002629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134002630 Walker A motif; other site 1127134002631 ATP binding site [chemical binding]; other site 1127134002632 Walker B motif; other site 1127134002633 arginine finger; other site 1127134002634 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134002635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1127134002636 Cupin domain; Region: Cupin_2; cl09118 1127134002637 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134002638 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127134002639 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134002640 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1127134002641 active site 1127134002642 classical (c) SDRs; Region: SDR_c; cd05233 1127134002643 NAD(P) binding site [chemical binding]; other site 1127134002644 active site 1127134002645 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1127134002646 Helix-turn-helix domains; Region: HTH; cl00088 1127134002647 AsnC family; Region: AsnC_trans_reg; pfam01037 1127134002648 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1127134002649 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1127134002650 TPP-binding site [chemical binding]; other site 1127134002651 tetramer interface [polypeptide binding]; other site 1127134002652 heterodimer interface [polypeptide binding]; other site 1127134002653 phosphorylation loop region [posttranslational modification] 1127134002654 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1127134002655 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1127134002656 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1127134002657 alpha subunit interface [polypeptide binding]; other site 1127134002658 TPP binding site [chemical binding]; other site 1127134002659 heterodimer interface [polypeptide binding]; other site 1127134002660 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1127134002661 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1127134002662 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1127134002663 E3 interaction surface; other site 1127134002664 lipoyl attachment site [posttranslational modification]; other site 1127134002665 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1127134002666 Benzoate membrane transport protein; Region: BenE; pfam03594 1127134002667 benzoate transporter; Region: benE; TIGR00843 1127134002668 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1127134002669 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1127134002670 active site residue [active] 1127134002671 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1127134002672 active site residue [active] 1127134002673 Protein of unknown function DUF262; Region: DUF262; cl14890 1127134002674 SNF2 Helicase protein; Region: DUF3670; pfam12419 1127134002675 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1127134002676 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134002677 ATP binding site [chemical binding]; other site 1127134002678 putative Mg++ binding site [ion binding]; other site 1127134002679 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134002680 nucleotide binding region [chemical binding]; other site 1127134002681 ATP-binding site [chemical binding]; other site 1127134002682 SWIM zinc finger; Region: SWIM; cl15408 1127134002683 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1127134002684 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127134002685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134002686 Helix-turn-helix domains; Region: HTH; cl00088 1127134002687 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1127134002688 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 1127134002689 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1127134002690 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134002691 tetrameric interface [polypeptide binding]; other site 1127134002692 NAD binding site [chemical binding]; other site 1127134002693 catalytic residues [active] 1127134002694 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134002695 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134002696 active site 1127134002697 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1127134002698 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134002699 substrate binding site [chemical binding]; other site 1127134002700 oxyanion hole (OAH) forming residues; other site 1127134002701 trimer interface [polypeptide binding]; other site 1127134002702 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1127134002703 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1127134002704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134002705 enoyl-CoA hydratase; Provisional; Region: PRK05862 1127134002706 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134002707 substrate binding site [chemical binding]; other site 1127134002708 oxyanion hole (OAH) forming residues; other site 1127134002709 trimer interface [polypeptide binding]; other site 1127134002710 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1127134002711 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1127134002712 Helix-turn-helix domains; Region: HTH; cl00088 1127134002713 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1127134002714 active site 1127134002715 metal binding site [ion binding]; metal-binding site 1127134002716 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134002717 Domain of unknown function (DUF305); Region: DUF305; cl15795 1127134002718 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1127134002719 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1127134002720 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 1127134002721 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1127134002722 active site 1127134002723 HIGH motif; other site 1127134002724 KMSK motif region; other site 1127134002725 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1127134002726 tRNA binding surface [nucleotide binding]; other site 1127134002727 anticodon binding site; other site 1127134002728 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1127134002729 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1127134002730 active site 1127134002731 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1127134002732 substrate binding site [chemical binding]; other site 1127134002733 catalytic residues [active] 1127134002734 dimer interface [polypeptide binding]; other site 1127134002735 homoserine dehydrogenase; Provisional; Region: PRK06349 1127134002736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134002737 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1127134002738 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1127134002739 threonine synthase; Reviewed; Region: PRK06721 1127134002740 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1127134002741 homodimer interface [polypeptide binding]; other site 1127134002742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134002743 catalytic residue [active] 1127134002744 homoserine kinase; Provisional; Region: PRK01212 1127134002745 transcription termination factor Rho; Provisional; Region: PRK12608 1127134002746 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1127134002747 RNA binding site [nucleotide binding]; other site 1127134002748 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1127134002749 multimer interface [polypeptide binding]; other site 1127134002750 Walker A motif; other site 1127134002751 ATP binding site [chemical binding]; other site 1127134002752 Walker B motif; other site 1127134002753 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1127134002754 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1127134002755 RF-1 domain; Region: RF-1; cl02875 1127134002756 RF-1 domain; Region: RF-1; cl02875 1127134002757 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1127134002758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134002759 S-adenosylmethionine binding site [chemical binding]; other site 1127134002760 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1127134002761 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1127134002762 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1127134002763 Mg++ binding site [ion binding]; other site 1127134002764 putative catalytic motif [active] 1127134002765 substrate binding site [chemical binding]; other site 1127134002766 ATP synthase A chain; Region: ATP-synt_A; cl00413 1127134002767 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1127134002768 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1127134002769 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1127134002770 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1127134002771 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1127134002772 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1127134002773 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1127134002774 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1127134002775 beta subunit interaction interface [polypeptide binding]; other site 1127134002776 Walker A motif; other site 1127134002777 ATP binding site [chemical binding]; other site 1127134002778 Walker B motif; other site 1127134002779 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1127134002780 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 1127134002781 ATP synthase; Region: ATP-synt; cl00365 1127134002782 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1127134002783 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1127134002784 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1127134002785 alpha subunit interaction interface [polypeptide binding]; other site 1127134002786 Walker A motif; other site 1127134002787 ATP binding site [chemical binding]; other site 1127134002788 Walker B motif; other site 1127134002789 inhibitor binding site; inhibition site 1127134002790 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1127134002791 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1127134002792 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 1127134002793 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1127134002794 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1127134002795 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1127134002796 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1127134002797 hinge; other site 1127134002798 active site 1127134002799 Protein of unknown function DUF91; Region: DUF91; cl00709 1127134002800 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127134002801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134002802 non-specific DNA binding site [nucleotide binding]; other site 1127134002803 salt bridge; other site 1127134002804 sequence-specific DNA binding site [nucleotide binding]; other site 1127134002805 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1127134002806 putative NAD(P) binding site [chemical binding]; other site 1127134002807 major vault protein; Provisional; Region: PTZ00491 1127134002808 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1127134002809 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134002810 dimer interface [polypeptide binding]; other site 1127134002811 substrate binding site [chemical binding]; other site 1127134002812 metal binding site [ion binding]; metal-binding site 1127134002813 putative acyltransferase; Provisional; Region: PRK05790 1127134002814 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1127134002815 dimer interface [polypeptide binding]; other site 1127134002816 active site 1127134002817 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 1127134002818 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1127134002819 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1127134002820 glycogen branching enzyme; Provisional; Region: PRK05402 1127134002821 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1127134002822 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1127134002823 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1127134002824 active site 1127134002825 catalytic site [active] 1127134002826 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1127134002827 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1127134002828 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1127134002829 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1127134002830 active site 1127134002831 catalytic site [active] 1127134002832 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1127134002833 putative homodimer interface [polypeptide binding]; other site 1127134002834 putative active site pocket [active] 1127134002835 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1127134002836 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1127134002837 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134002838 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134002839 active site 1127134002840 ATP binding site [chemical binding]; other site 1127134002841 substrate binding site [chemical binding]; other site 1127134002842 activation loop (A-loop); other site 1127134002843 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1127134002844 homotrimer interaction site [polypeptide binding]; other site 1127134002845 putative active site [active] 1127134002846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134002847 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134002848 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1127134002849 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134002850 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134002851 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1127134002852 Isochorismatase family; Region: Isochorismatase; pfam00857 1127134002853 catalytic triad [active] 1127134002854 metal binding site [ion binding]; metal-binding site 1127134002855 conserved cis-peptide bond; other site 1127134002856 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1127134002857 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1127134002858 active site 1127134002859 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1127134002860 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1127134002861 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1127134002862 putative active site pocket [active] 1127134002863 cleavage site 1127134002864 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1127134002865 MPN+ (JAMM) motif; other site 1127134002866 Zinc-binding site [ion binding]; other site 1127134002867 Ubiquitin-like proteins; Region: UBQ; cl00155 1127134002868 charged pocket; other site 1127134002869 hydrophobic patch; other site 1127134002870 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1127134002871 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1127134002872 dimer interface [polypeptide binding]; other site 1127134002873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134002874 catalytic residue [active] 1127134002875 Rhomboid family; Region: Rhomboid; cl11446 1127134002876 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134002877 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1127134002878 hexamer interface [polypeptide binding]; other site 1127134002879 active site 1127134002880 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1127134002881 active site 1127134002882 dimerization interface [polypeptide binding]; other site 1127134002883 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1127134002884 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 1127134002885 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134002886 short chain dehydrogenase; Provisional; Region: PRK06197 1127134002887 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1127134002888 putative NAD(P) binding site [chemical binding]; other site 1127134002889 active site 1127134002890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134002891 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134002892 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1127134002893 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1127134002894 active site 1127134002895 EspG family; Region: ESX-1_EspG; pfam14011 1127134002896 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1127134002897 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134002898 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134002899 DNA binding residues [nucleotide binding] 1127134002900 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134002901 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134002902 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1127134002903 LysE type translocator; Region: LysE; cl00565 1127134002904 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1127134002905 Helix-turn-helix domains; Region: HTH; cl00088 1127134002906 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134002907 dimerization interface [polypeptide binding]; other site 1127134002908 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1127134002909 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134002910 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1127134002911 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134002912 DNA binding residues [nucleotide binding] 1127134002913 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1127134002914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134002915 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127134002916 putative substrate translocation pore; other site 1127134002917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134002918 Helix-turn-helix domains; Region: HTH; cl00088 1127134002919 hypothetical protein; Provisional; Region: PRK06847 1127134002920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134002921 Protein of unknown function DUF262; Region: DUF262; cl14890 1127134002922 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 1127134002923 gating phenylalanine in ion channel; other site 1127134002924 Helix-turn-helix domains; Region: HTH; cl00088 1127134002925 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134002926 dimerization interface [polypeptide binding]; other site 1127134002927 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1127134002928 PhoU domain; Region: PhoU; pfam01895 1127134002929 Permease; Region: Permease; cl00510 1127134002930 hypothetical protein; Region: PHA00727 1127134002931 Permease; Region: Permease; cl00510 1127134002932 mce related protein; Region: MCE; pfam02470 1127134002933 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1127134002934 mce related protein; Region: MCE; pfam02470 1127134002935 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134002936 mce related protein; Region: MCE; pfam02470 1127134002937 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134002938 mce related protein; Region: MCE; pfam02470 1127134002939 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134002940 mce related protein; Region: MCE; pfam02470 1127134002941 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1127134002942 mce related protein; Region: MCE; pfam02470 1127134002943 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1127134002944 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134002945 putative DNA binding site [nucleotide binding]; other site 1127134002946 putative Zn2+ binding site [ion binding]; other site 1127134002947 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134002948 Helix-turn-helix domains; Region: HTH; cl00088 1127134002949 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134002950 hydrophobic ligand binding site; other site 1127134002951 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134002952 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134002953 mce related protein; Region: MCE; pfam02470 1127134002954 mce related protein; Region: MCE; pfam02470 1127134002955 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134002956 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134002957 mce related protein; Region: MCE; pfam02470 1127134002958 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134002959 mce related protein; Region: MCE; pfam02470 1127134002960 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134002961 mce related protein; Region: MCE; pfam02470 1127134002962 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1127134002963 Permease; Region: Permease; cl00510 1127134002964 Permease; Region: Permease; cl00510 1127134002965 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1127134002966 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1127134002967 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127134002968 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134002969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134002970 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1127134002971 PAS domain S-box; Region: sensory_box; TIGR00229 1127134002972 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127134002973 putative active site [active] 1127134002974 heme pocket [chemical binding]; other site 1127134002975 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1127134002976 metal binding site [ion binding]; metal-binding site 1127134002977 active site 1127134002978 I-site; other site 1127134002979 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1127134002980 short chain dehydrogenase; Provisional; Region: PRK06914 1127134002981 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1127134002982 NADP binding site [chemical binding]; other site 1127134002983 active site 1127134002984 steroid binding site; other site 1127134002985 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1127134002986 Predicted transcriptional regulator [Transcription]; Region: COG1959 1127134002987 Helix-turn-helix domains; Region: HTH; cl00088 1127134002988 Protein of unknown function DUF72; Region: DUF72; cl00777 1127134002989 Dehydratase family; Region: ILVD_EDD; cl00340 1127134002990 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1127134002991 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1127134002992 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134002993 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134002994 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1127134002995 active site 1127134002996 ATP binding site [chemical binding]; other site 1127134002997 substrate binding site [chemical binding]; other site 1127134002998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134002999 Helix-turn-helix domains; Region: HTH; cl00088 1127134003000 Helix-turn-helix domains; Region: HTH; cl00088 1127134003001 Secretory lipase; Region: LIP; pfam03583 1127134003002 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134003003 Helix-turn-helix domains; Region: HTH; cl00088 1127134003004 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1127134003005 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1127134003006 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134003007 hydrophobic ligand binding site; other site 1127134003008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134003009 TIGR01777 family protein; Region: yfcH 1127134003010 NAD(P) binding site [chemical binding]; other site 1127134003011 active site 1127134003012 AAA domain; Region: AAA_21; pfam13304 1127134003013 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1127134003014 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1127134003015 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1127134003016 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134003017 active site 2 [active] 1127134003018 active site 1 [active] 1127134003019 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1127134003020 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1127134003021 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1127134003022 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1127134003023 putative NAD(P) binding site [chemical binding]; other site 1127134003024 active site 1127134003025 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 1127134003026 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1127134003027 active site 1127134003028 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1127134003029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134003030 Helix-turn-helix domains; Region: HTH; cl00088 1127134003031 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134003032 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134003033 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1127134003034 Walker A/P-loop; other site 1127134003035 ATP binding site [chemical binding]; other site 1127134003036 Q-loop/lid; other site 1127134003037 ABC transporter signature motif; other site 1127134003038 Walker B; other site 1127134003039 D-loop; other site 1127134003040 H-loop/switch region; other site 1127134003041 Helix-turn-helix domains; Region: HTH; cl00088 1127134003042 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1127134003043 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1127134003044 catalytic triad [active] 1127134003045 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1127134003046 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1127134003047 OpgC protein; Region: OpgC_C; cl00792 1127134003048 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127134003049 Helix-turn-helix domains; Region: HTH; cl00088 1127134003050 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1127134003051 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1127134003052 catalytic residue [active] 1127134003053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1127134003054 Bacterial Ig-like domain; Region: Big_5; cl01012 1127134003055 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1127134003056 amino acid transporter; Region: 2A0306; TIGR00909 1127134003057 Spore germination protein; Region: Spore_permease; cl15802 1127134003058 Spore germination protein; Region: Spore_permease; cl15802 1127134003059 Spore germination protein; Region: Spore_permease; cl15802 1127134003060 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1127134003061 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 1127134003062 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1127134003063 NAD binding site [chemical binding]; other site 1127134003064 Phe binding site; other site 1127134003065 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1127134003066 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1127134003067 dimer interface [polypeptide binding]; other site 1127134003068 PYR/PP interface [polypeptide binding]; other site 1127134003069 TPP binding site [chemical binding]; other site 1127134003070 substrate binding site [chemical binding]; other site 1127134003071 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1127134003072 TPP-binding site [chemical binding]; other site 1127134003073 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1127134003074 Helix-turn-helix domains; Region: HTH; cl00088 1127134003075 AsnC family; Region: AsnC_trans_reg; pfam01037 1127134003076 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1127134003077 putative active site [active] 1127134003078 putative substrate binding site [chemical binding]; other site 1127134003079 dimer interface [polypeptide binding]; other site 1127134003080 catalytic site [active] 1127134003081 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1127134003082 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1127134003083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134003084 NAD(P) binding site [chemical binding]; other site 1127134003085 active site 1127134003086 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1127134003087 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1127134003088 active site 1127134003089 FMN binding site [chemical binding]; other site 1127134003090 2,4-decadienoyl-CoA binding site; other site 1127134003091 catalytic residue [active] 1127134003092 4Fe-4S cluster binding site [ion binding]; other site 1127134003093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134003094 Helix-turn-helix domains; Region: HTH; cl00088 1127134003095 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1127134003096 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 1127134003097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134003098 putative substrate translocation pore; other site 1127134003099 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1127134003100 Helix-turn-helix domains; Region: HTH; cl00088 1127134003101 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1127134003102 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1127134003103 FAD binding pocket [chemical binding]; other site 1127134003104 FAD binding motif [chemical binding]; other site 1127134003105 phosphate binding motif [ion binding]; other site 1127134003106 beta-alpha-beta structure motif; other site 1127134003107 NAD binding pocket [chemical binding]; other site 1127134003108 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1127134003109 catalytic loop [active] 1127134003110 iron binding site [ion binding]; other site 1127134003111 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1127134003112 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1127134003113 putative di-iron ligands [ion binding]; other site 1127134003114 Foamy virus envelope protein; Region: Foamy_virus_ENV; pfam03408 1127134003115 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1127134003116 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1127134003117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134003118 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1127134003119 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1127134003120 dimer interface [polypeptide binding]; other site 1127134003121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134003122 catalytic residue [active] 1127134003123 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1127134003124 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1127134003125 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134003126 Walker A/P-loop; other site 1127134003127 ATP binding site [chemical binding]; other site 1127134003128 Q-loop/lid; other site 1127134003129 ABC transporter signature motif; other site 1127134003130 Walker B; other site 1127134003131 D-loop; other site 1127134003132 H-loop/switch region; other site 1127134003133 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1127134003134 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1127134003135 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127134003136 Helix-turn-helix domains; Region: HTH; cl00088 1127134003137 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134003138 dimerization interface [polypeptide binding]; other site 1127134003139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134003140 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1127134003141 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1127134003142 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134003143 tetrameric interface [polypeptide binding]; other site 1127134003144 NAD binding site [chemical binding]; other site 1127134003145 catalytic residues [active] 1127134003146 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1127134003147 Copper resistance protein D; Region: CopD; cl00563 1127134003148 Copper resistance protein D; Region: CopD; cl00563 1127134003149 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1127134003150 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1127134003151 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1127134003152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134003153 catalytic residue [active] 1127134003154 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1127134003155 dimer interface [polypeptide binding]; other site 1127134003156 ssDNA binding site [nucleotide binding]; other site 1127134003157 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1127134003158 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1127134003159 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1127134003160 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1127134003161 ABC transporter; Region: ABC_tran_2; pfam12848 1127134003162 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1127134003163 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1127134003164 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1127134003165 active site 1127134003166 AzlC protein; Region: AzlC; cl00570 1127134003167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134003168 non-specific DNA binding site [nucleotide binding]; other site 1127134003169 salt bridge; other site 1127134003170 sequence-specific DNA binding site [nucleotide binding]; other site 1127134003171 Cupin domain; Region: Cupin_2; cl09118 1127134003172 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1127134003173 active site 1127134003174 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1127134003175 apolar tunnel; other site 1127134003176 heme binding site [chemical binding]; other site 1127134003177 dimerization interface [polypeptide binding]; other site 1127134003178 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1127134003179 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1127134003180 active site 1127134003181 catalytic site [active] 1127134003182 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1127134003183 Repair protein; Region: Repair_PSII; cl01535 1127134003184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134003185 non-specific DNA binding site [nucleotide binding]; other site 1127134003186 salt bridge; other site 1127134003187 sequence-specific DNA binding site [nucleotide binding]; other site 1127134003188 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1127134003189 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1127134003190 oligomer interface [polypeptide binding]; other site 1127134003191 active site residues [active] 1127134003192 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1127134003193 oligomer interface [polypeptide binding]; other site 1127134003194 active site residues [active] 1127134003195 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1127134003196 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1127134003197 Zn binding site [ion binding]; other site 1127134003198 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1127134003199 ATP binding site [chemical binding]; other site 1127134003200 active site 1127134003201 substrate binding site [chemical binding]; other site 1127134003202 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1127134003203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134003204 YCII-related domain; Region: YCII; cl00999 1127134003205 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1127134003206 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134003207 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1127134003208 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1127134003209 catalytic residues [active] 1127134003210 Peptidase family M48; Region: Peptidase_M48; cl12018 1127134003211 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1127134003212 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1127134003213 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1127134003214 putative DNA binding site [nucleotide binding]; other site 1127134003215 catalytic residue [active] 1127134003216 putative H2TH interface [polypeptide binding]; other site 1127134003217 putative catalytic residues [active] 1127134003218 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1127134003219 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1127134003220 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1127134003221 metal binding site [ion binding]; metal-binding site 1127134003222 active site 1127134003223 I-site; other site 1127134003224 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134003225 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134003226 DNA binding residues [nucleotide binding] 1127134003227 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1127134003228 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1127134003229 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1127134003230 AAA-like domain; Region: AAA_10; pfam12846 1127134003231 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1127134003232 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1127134003233 catalytic residue [active] 1127134003234 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1127134003235 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1127134003236 catalytic residue [active] 1127134003237 PPE family; Region: PPE; pfam00823 1127134003238 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1127134003239 NlpC/P60 family; Region: NLPC_P60; cl11438 1127134003240 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1127134003241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134003242 Walker A motif; other site 1127134003243 ATP binding site [chemical binding]; other site 1127134003244 Walker B motif; other site 1127134003245 arginine finger; other site 1127134003246 Protein of unknown function (DUF690); Region: DUF690; cl04939 1127134003247 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1127134003248 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134003249 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134003250 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1127134003251 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134003252 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134003253 PPE family; Region: PPE; pfam00823 1127134003254 EspG family; Region: ESX-1_EspG; pfam14011 1127134003255 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1127134003256 Ubiquitin-like proteins; Region: UBQ; cl00155 1127134003257 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1127134003258 active site 1127134003259 catalytic residues [active] 1127134003260 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 1127134003261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134003262 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1127134003263 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1127134003264 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1127134003265 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1127134003266 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1127134003267 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1127134003268 L-asparagine permease; Provisional; Region: PRK15049 1127134003269 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134003270 active site 1127134003271 ATP binding site [chemical binding]; other site 1127134003272 substrate binding site [chemical binding]; other site 1127134003273 activation loop (A-loop); other site 1127134003274 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1127134003275 Transcription factor WhiB; Region: Whib; pfam02467 1127134003276 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134003277 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134003278 DNA binding residues [nucleotide binding] 1127134003279 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134003280 Predicted ATPase [General function prediction only]; Region: COG3903 1127134003281 Helix-turn-helix domains; Region: HTH; cl00088 1127134003282 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134003283 putative phosphoketolase; Provisional; Region: PRK05261 1127134003284 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1127134003285 TPP-binding site [chemical binding]; other site 1127134003286 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 1127134003287 XFP C-terminal domain; Region: XFP_C; pfam09363 1127134003288 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1127134003289 trigger factor; Provisional; Region: tig; PRK01490 1127134003290 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1127134003291 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1127134003292 Clp protease; Region: CLP_protease; pfam00574 1127134003293 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1127134003294 oligomer interface [polypeptide binding]; other site 1127134003295 active site residues [active] 1127134003296 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1127134003297 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1127134003298 oligomer interface [polypeptide binding]; other site 1127134003299 active site residues [active] 1127134003300 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1127134003301 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1127134003302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134003303 Walker A motif; other site 1127134003304 ATP binding site [chemical binding]; other site 1127134003305 Walker B motif; other site 1127134003306 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1127134003307 aminoacyl-tRNA ligase; Region: PLN02882 1127134003308 ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon; Region: ketosteroid_isomerase; cd00781 1127134003309 dimer interface [polypeptide binding]; other site 1127134003310 active site/substrate binding site [active] 1127134003311 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1127134003312 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1127134003313 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1127134003314 putative molybdopterin cofactor binding site [chemical binding]; other site 1127134003315 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1127134003316 putative molybdopterin cofactor binding site; other site 1127134003317 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1127134003318 phosphopeptide binding site; other site 1127134003319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1127134003320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127134003321 Coenzyme A binding pocket [chemical binding]; other site 1127134003322 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1127134003323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134003324 Helix-turn-helix domains; Region: HTH; cl00088 1127134003325 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1127134003326 FAD binding domain; Region: FAD_binding_4; pfam01565 1127134003327 diacylglycerol kinase; Reviewed; Region: PRK11914 1127134003328 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1127134003329 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1127134003330 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1127134003331 active site 1127134003332 HIGH motif; other site 1127134003333 nucleotide binding site [chemical binding]; other site 1127134003334 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1127134003335 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1127134003336 active site 1127134003337 KMSKS motif; other site 1127134003338 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1127134003339 tRNA binding surface [nucleotide binding]; other site 1127134003340 anticodon binding site; other site 1127134003341 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1127134003342 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1127134003343 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1127134003344 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1127134003345 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1127134003346 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1127134003347 active site 1127134003348 multimer interface [polypeptide binding]; other site 1127134003349 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1127134003350 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1127134003351 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1127134003352 homodimer interface [polypeptide binding]; other site 1127134003353 oligonucleotide binding site [chemical binding]; other site 1127134003354 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 1127134003355 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 1127134003356 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1127134003357 GTP1/OBG; Region: GTP1_OBG; pfam01018 1127134003358 Obg GTPase; Region: Obg; cd01898 1127134003359 G1 box; other site 1127134003360 GTP/Mg2+ binding site [chemical binding]; other site 1127134003361 Switch I region; other site 1127134003362 G2 box; other site 1127134003363 G3 box; other site 1127134003364 Switch II region; other site 1127134003365 G4 box; other site 1127134003366 G5 box; other site 1127134003367 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 1127134003368 gamma-glutamyl kinase; Provisional; Region: PRK05429 1127134003369 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1127134003370 nucleotide binding site [chemical binding]; other site 1127134003371 homotetrameric interface [polypeptide binding]; other site 1127134003372 putative phosphate binding site [ion binding]; other site 1127134003373 putative allosteric binding site; other site 1127134003374 PUA domain; Region: PUA; cl00607 1127134003375 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1127134003376 putative active site [active] 1127134003377 EspG family; Region: ESX-1_EspG; pfam14011 1127134003378 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1127134003379 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1127134003380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134003381 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1127134003382 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134003383 acyl-CoA synthetase; Validated; Region: PRK09192 1127134003384 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1127134003385 active site 1127134003386 NTP binding site [chemical binding]; other site 1127134003387 metal binding triad [ion binding]; metal-binding site 1127134003388 antibiotic binding site [chemical binding]; other site 1127134003389 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134003390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134003391 NAD(P) binding site [chemical binding]; other site 1127134003392 active site 1127134003393 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 1127134003394 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134003395 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134003396 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1127134003397 FMN binding site [chemical binding]; other site 1127134003398 dimer interface [polypeptide binding]; other site 1127134003399 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1127134003400 O-methyltransferase; Region: Methyltransf_2; pfam00891 1127134003401 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134003402 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134003403 DNA binding residues [nucleotide binding] 1127134003404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134003405 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1127134003406 nucleotide binding site [chemical binding]; other site 1127134003407 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1127134003408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134003409 ATP binding site [chemical binding]; other site 1127134003410 putative Mg++ binding site [ion binding]; other site 1127134003411 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134003412 nucleotide binding region [chemical binding]; other site 1127134003413 ATP-binding site [chemical binding]; other site 1127134003414 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1127134003415 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 1127134003416 hypothetical protein; Reviewed; Region: PRK09588 1127134003417 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1127134003418 substrate binding site [chemical binding]; other site 1127134003419 dimer interface [polypeptide binding]; other site 1127134003420 ATP binding site [chemical binding]; other site 1127134003421 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1127134003422 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1127134003423 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1127134003424 putative catalytic cysteine [active] 1127134003425 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1127134003426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134003427 Walker A motif; other site 1127134003428 ATP binding site [chemical binding]; other site 1127134003429 Walker B motif; other site 1127134003430 arginine finger; other site 1127134003431 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1127134003432 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1127134003433 HSP90 family protein; Provisional; Region: PRK14083 1127134003434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134003435 ATP binding site [chemical binding]; other site 1127134003436 Mg2+ binding site [ion binding]; other site 1127134003437 G-X-G motif; other site 1127134003438 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127134003439 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1127134003440 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1127134003441 active site 1127134003442 (T/H)XGH motif; other site 1127134003443 Oligomerisation domain; Region: Oligomerisation; cl00519 1127134003444 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127134003445 catalytic core [active] 1127134003446 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1127134003447 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1127134003448 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1127134003449 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1127134003450 Competence protein; Region: Competence; cl00471 1127134003451 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134003452 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134003453 hypothetical protein; Reviewed; Region: PRK07914 1127134003454 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 1127134003455 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1127134003456 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127134003457 active site 1127134003458 catalytic tetrad [active] 1127134003459 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134003460 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 1127134003461 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1127134003462 amphipathic channel; other site 1127134003463 Asn-Pro-Ala signature motifs; other site 1127134003464 PemK-like protein; Region: PemK; cl00995 1127134003465 GTP-binding protein LepA; Provisional; Region: PRK05433 1127134003466 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1127134003467 G1 box; other site 1127134003468 putative GEF interaction site [polypeptide binding]; other site 1127134003469 GTP/Mg2+ binding site [chemical binding]; other site 1127134003470 Switch I region; other site 1127134003471 G2 box; other site 1127134003472 G3 box; other site 1127134003473 Switch II region; other site 1127134003474 G4 box; other site 1127134003475 G5 box; other site 1127134003476 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1127134003477 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1127134003478 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1127134003479 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1127134003480 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134003481 Dynamin family; Region: Dynamin_N; pfam00350 1127134003482 G1 box; other site 1127134003483 GTP/Mg2+ binding site [chemical binding]; other site 1127134003484 Switch I region; other site 1127134003485 G3 box; other site 1127134003486 Switch II region; other site 1127134003487 G4 box; other site 1127134003488 G5 box; other site 1127134003489 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1127134003490 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1127134003491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134003492 S-adenosylmethionine binding site [chemical binding]; other site 1127134003493 Peptidase family M48; Region: Peptidase_M48; cl12018 1127134003494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134003495 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1127134003496 sulfate transport protein; Provisional; Region: cysT; CHL00187 1127134003497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134003498 dimer interface [polypeptide binding]; other site 1127134003499 conserved gate region; other site 1127134003500 putative PBP binding loops; other site 1127134003501 ABC-ATPase subunit interface; other site 1127134003502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134003503 dimer interface [polypeptide binding]; other site 1127134003504 conserved gate region; other site 1127134003505 putative PBP binding loops; other site 1127134003506 ABC-ATPase subunit interface; other site 1127134003507 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1127134003508 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 1127134003509 Walker A/P-loop; other site 1127134003510 ATP binding site [chemical binding]; other site 1127134003511 Q-loop/lid; other site 1127134003512 ABC transporter signature motif; other site 1127134003513 Walker B; other site 1127134003514 D-loop; other site 1127134003515 H-loop/switch region; other site 1127134003516 TOBE-like domain; Region: TOBE_3; pfam12857 1127134003517 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1127134003518 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1127134003519 Ferredoxin [Energy production and conversion]; Region: COG1146 1127134003520 4Fe-4S binding domain; Region: Fer4; cl02805 1127134003521 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1127134003522 ferredoxin-NADP+ reductase; Region: PLN02852 1127134003523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134003524 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1127134003525 classical (c) SDRs; Region: SDR_c; cd05233 1127134003526 NAD(P) binding site [chemical binding]; other site 1127134003527 active site 1127134003528 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1127134003529 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1127134003530 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134003531 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134003532 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1127134003533 active site 1127134003534 substrate binding pocket [chemical binding]; other site 1127134003535 homodimer interaction site [polypeptide binding]; other site 1127134003536 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1127134003537 DNA-binding interface [nucleotide binding]; DNA binding site 1127134003538 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1127134003539 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134003540 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1127134003541 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134003542 active site 1127134003543 metal binding site [ion binding]; metal-binding site 1127134003544 Predicted transcriptional regulator [Transcription]; Region: COG2378 1127134003545 Helix-turn-helix domains; Region: HTH; cl00088 1127134003546 WYL domain; Region: WYL; cl14852 1127134003547 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1127134003548 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1127134003549 putative active site [active] 1127134003550 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1127134003551 active site 1127134003552 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 1127134003553 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1127134003554 CysD dimerization site [polypeptide binding]; other site 1127134003555 G1 box; other site 1127134003556 putative GEF interaction site [polypeptide binding]; other site 1127134003557 GTP/Mg2+ binding site [chemical binding]; other site 1127134003558 Switch I region; other site 1127134003559 G2 box; other site 1127134003560 G3 box; other site 1127134003561 Switch II region; other site 1127134003562 G4 box; other site 1127134003563 G5 box; other site 1127134003564 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1127134003565 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1127134003566 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1127134003567 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1127134003568 Active Sites [active] 1127134003569 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1127134003570 Active Sites [active] 1127134003571 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1127134003572 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1127134003573 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1127134003574 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134003575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 1127134003576 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1127134003577 chaperone protein DnaJ; Provisional; Region: PRK14278 1127134003578 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1127134003579 HSP70 interaction site [polypeptide binding]; other site 1127134003580 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1127134003581 Zn binding sites [ion binding]; other site 1127134003582 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1127134003583 dimer interface [polypeptide binding]; other site 1127134003584 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1127134003585 Helix-turn-helix domains; Region: HTH; cl00088 1127134003586 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1127134003587 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1127134003588 HemN C-terminal domain; Region: HemN_C; pfam06969 1127134003589 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1127134003590 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134003591 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 1127134003592 Domain of unknown function DUF21; Region: DUF21; pfam01595 1127134003593 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1127134003594 Transporter associated domain; Region: CorC_HlyC; cl08393 1127134003595 GTPase Era; Reviewed; Region: era; PRK00089 1127134003596 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1127134003597 G1 box; other site 1127134003598 GTP/Mg2+ binding site [chemical binding]; other site 1127134003599 Switch I region; other site 1127134003600 G2 box; other site 1127134003601 Switch II region; other site 1127134003602 G3 box; other site 1127134003603 G4 box; other site 1127134003604 G5 box; other site 1127134003605 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1127134003606 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134003607 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134003608 active site 1127134003609 ATP binding site [chemical binding]; other site 1127134003610 substrate binding site [chemical binding]; other site 1127134003611 activation loop (A-loop); other site 1127134003612 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134003613 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134003614 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134003615 active site 1127134003616 ATP binding site [chemical binding]; other site 1127134003617 substrate binding site [chemical binding]; other site 1127134003618 activation loop (A-loop); other site 1127134003619 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1127134003620 amidase; Provisional; Region: PRK06061 1127134003621 Amidase; Region: Amidase; cl11426 1127134003622 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134003623 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1127134003624 active site 1127134003625 ADP-ribosylating toxin turn-turn motif; other site 1127134003626 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134003627 Helix-turn-helix domains; Region: HTH; cl00088 1127134003628 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1127134003629 Recombination protein O N terminal; Region: RecO_N; cl15812 1127134003630 Recombination protein O C terminal; Region: RecO_C; pfam02565 1127134003631 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1127134003632 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1127134003633 catalytic residue [active] 1127134003634 putative FPP diphosphate binding site; other site 1127134003635 putative FPP binding hydrophobic cleft; other site 1127134003636 dimer interface [polypeptide binding]; other site 1127134003637 putative IPP diphosphate binding site; other site 1127134003638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134003639 Helix-turn-helix domains; Region: HTH; cl00088 1127134003640 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1127134003641 metal binding site 2 [ion binding]; metal-binding site 1127134003642 putative DNA binding helix; other site 1127134003643 metal binding site 1 [ion binding]; metal-binding site 1127134003644 dimer interface [polypeptide binding]; other site 1127134003645 structural Zn2+ binding site [ion binding]; other site 1127134003646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134003647 dimerization interface [polypeptide binding]; other site 1127134003648 putative DNA binding site [nucleotide binding]; other site 1127134003649 putative Zn2+ binding site [ion binding]; other site 1127134003650 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1127134003651 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1127134003652 motif 1; other site 1127134003653 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 1127134003654 active site 1127134003655 motif 2; other site 1127134003656 motif 3; other site 1127134003657 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1127134003658 anticodon binding site; other site 1127134003659 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1127134003660 acyltransferase PapA5; Provisional; Region: PRK09294 1127134003661 Repair protein; Region: Repair_PSII; cl01535 1127134003662 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134003663 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1127134003664 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127134003665 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134003666 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1127134003667 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1127134003668 carboxyltransferase (CT) interaction site; other site 1127134003669 biotinylation site [posttranslational modification]; other site 1127134003670 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 1127134003671 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1127134003672 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134003673 dimerization interface [polypeptide binding]; other site 1127134003674 putative DNA binding site [nucleotide binding]; other site 1127134003675 putative Zn2+ binding site [ion binding]; other site 1127134003676 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1127134003677 putative hydrophobic ligand binding site [chemical binding]; other site 1127134003678 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1127134003679 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 1127134003680 Secretory lipase; Region: LIP; pfam03583 1127134003681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134003682 Helix-turn-helix domains; Region: HTH; cl00088 1127134003683 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1127134003684 putative active site [active] 1127134003685 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1127134003686 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1127134003687 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1127134003688 DNA primase; Validated; Region: dnaG; PRK05667 1127134003689 CHC2 zinc finger; Region: zf-CHC2; cl15369 1127134003690 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1127134003691 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1127134003692 active site 1127134003693 metal binding site [ion binding]; metal-binding site 1127134003694 interdomain interaction site; other site 1127134003695 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1127134003696 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 1127134003697 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1127134003698 active site 1127134003699 DNA binding site [nucleotide binding] 1127134003700 Int/Topo IB signature motif; other site 1127134003701 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1127134003702 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1127134003703 Helix-turn-helix domain; Region: HTH_18; pfam12833 1127134003704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134003705 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1127134003706 catalytic loop [active] 1127134003707 iron binding site [ion binding]; other site 1127134003708 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134003709 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1127134003710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134003711 Permease; Region: Permease; cl00510 1127134003712 Permease; Region: Permease; cl00510 1127134003713 mce related protein; Region: MCE; pfam02470 1127134003714 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134003715 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134003716 mce related protein; Region: MCE; pfam02470 1127134003717 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134003718 mce related protein; Region: MCE; pfam02470 1127134003719 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134003720 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134003721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134003722 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1127134003723 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134003724 short chain dehydrogenase; Provisional; Region: PRK07825 1127134003725 classical (c) SDRs; Region: SDR_c; cd05233 1127134003726 NAD(P) binding site [chemical binding]; other site 1127134003727 active site 1127134003728 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1127134003729 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1127134003730 FAD binding pocket [chemical binding]; other site 1127134003731 FAD binding motif [chemical binding]; other site 1127134003732 phosphate binding motif [ion binding]; other site 1127134003733 beta-alpha-beta structure motif; other site 1127134003734 NAD(p) ribose binding residues [chemical binding]; other site 1127134003735 NAD binding pocket [chemical binding]; other site 1127134003736 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1127134003737 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1127134003738 catalytic loop [active] 1127134003739 iron binding site [ion binding]; other site 1127134003740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134003741 Helix-turn-helix domains; Region: HTH; cl00088 1127134003742 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134003743 subunit interaction site [polypeptide binding]; other site 1127134003744 PHB binding site; other site 1127134003745 CoenzymeA binding site [chemical binding]; other site 1127134003746 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134003747 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1127134003748 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 1127134003749 putative active site [active] 1127134003750 Helix-turn-helix domains; Region: HTH; cl00088 1127134003751 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1127134003752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134003753 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1127134003754 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134003755 CoenzymeA binding site [chemical binding]; other site 1127134003756 subunit interaction site [polypeptide binding]; other site 1127134003757 PHB binding site; other site 1127134003758 Domain of unknown function DUF302; Region: DUF302; cl01364 1127134003759 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1127134003760 putative homodimer interface [polypeptide binding]; other site 1127134003761 putative homotetramer interface [polypeptide binding]; other site 1127134003762 putative allosteric switch controlling residues; other site 1127134003763 putative metal binding site [ion binding]; other site 1127134003764 putative homodimer-homodimer interface [polypeptide binding]; other site 1127134003765 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127134003766 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1127134003767 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1127134003768 catalytic residues [active] 1127134003769 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1127134003770 Creatinine amidohydrolase; Region: Creatininase; cl00618 1127134003771 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1127134003772 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134003773 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1127134003774 Prephenate dehydratase; Region: PDT; pfam00800 1127134003775 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1127134003776 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1127134003777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134003778 non-specific DNA binding site [nucleotide binding]; other site 1127134003779 salt bridge; other site 1127134003780 sequence-specific DNA binding site [nucleotide binding]; other site 1127134003781 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1127134003782 nudix motif; other site 1127134003783 RNHCP domain; Region: RNHCP; pfam12647 1127134003784 RNHCP domain; Region: RNHCP; pfam12647 1127134003785 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1127134003786 Fasciclin domain; Region: Fasciclin; cl02663 1127134003787 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1127134003788 DNA photolyase; Region: DNA_photolyase; pfam00875 1127134003789 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1127134003790 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 1127134003791 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1127134003792 DNA binding residues [nucleotide binding] 1127134003793 B12 binding domain; Region: B12-binding_2; cl03653 1127134003794 Transport protein; Region: actII; TIGR00833 1127134003795 Transport protein; Region: actII; TIGR00833 1127134003796 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1127134003797 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1127134003798 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134003799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1127134003800 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134003801 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134003802 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134003803 acyl-CoA synthetase; Validated; Region: PRK06188 1127134003804 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134003805 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134003806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134003807 Helix-turn-helix domains; Region: HTH; cl00088 1127134003808 lipid-transfer protein; Provisional; Region: PRK08256 1127134003809 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1127134003810 active site 1127134003811 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1127134003812 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1127134003813 active site 1127134003814 lipid-transfer protein; Provisional; Region: PRK07937 1127134003815 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1127134003816 active site 1127134003817 Evidence 4 : Homologs of previously reported genes of unknown function 1127134003818 Evidence 4 : Homologs of previously reported genes of unknown function 1127134003819 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1127134003820 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134003821 NAD(P) binding site [chemical binding]; other site 1127134003822 catalytic residues [active] 1127134003823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134003824 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1127134003825 NAD(P) binding site [chemical binding]; other site 1127134003826 active site 1127134003827 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134003828 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134003829 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1127134003830 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1127134003831 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1127134003832 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1127134003833 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1127134003834 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1127134003835 FMN-binding pocket [chemical binding]; other site 1127134003836 flavin binding motif; other site 1127134003837 phosphate binding motif [ion binding]; other site 1127134003838 beta-alpha-beta structure motif; other site 1127134003839 NAD binding pocket [chemical binding]; other site 1127134003840 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1127134003841 catalytic loop [active] 1127134003842 iron binding site [ion binding]; other site 1127134003843 short chain dehydrogenase; Validated; Region: PRK05855 1127134003844 classical (c) SDRs; Region: SDR_c; cd05233 1127134003845 NAD(P) binding site [chemical binding]; other site 1127134003846 active site 1127134003847 Uncharacterized conserved protein [Function unknown]; Region: COG4278 1127134003848 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 1127134003849 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1127134003850 putative NAD(P) binding site [chemical binding]; other site 1127134003851 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134003852 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134003853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134003854 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1127134003855 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 1127134003856 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1127134003857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134003858 Helix-turn-helix domains; Region: HTH; cl00088 1127134003859 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1127134003860 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1127134003861 dimer interface [polypeptide binding]; other site 1127134003862 active site 1127134003863 CoA binding pocket [chemical binding]; other site 1127134003864 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1127134003865 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1127134003866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134003867 active site 1127134003868 phosphorylation site [posttranslational modification] 1127134003869 intermolecular recognition site; other site 1127134003870 dimerization interface [polypeptide binding]; other site 1127134003871 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127134003872 DNA binding site [nucleotide binding] 1127134003873 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127134003874 dimerization interface [polypeptide binding]; other site 1127134003875 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127134003876 dimer interface [polypeptide binding]; other site 1127134003877 phosphorylation site [posttranslational modification] 1127134003878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134003879 ATP binding site [chemical binding]; other site 1127134003880 Mg2+ binding site [ion binding]; other site 1127134003881 G-X-G motif; other site 1127134003882 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1127134003883 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1127134003884 homodimer interface [polypeptide binding]; other site 1127134003885 putative substrate binding pocket [chemical binding]; other site 1127134003886 diiron center [ion binding]; other site 1127134003887 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1127134003888 RNA/DNA hybrid binding site [nucleotide binding]; other site 1127134003889 active site 1127134003890 YCII-related domain; Region: YCII; cl00999 1127134003891 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1127134003892 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134003893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134003894 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1127134003895 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134003896 DNA binding residues [nucleotide binding] 1127134003897 drug binding residues [chemical binding]; other site 1127134003898 dimer interface [polypeptide binding]; other site 1127134003899 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl02940 1127134003900 DNA polymerase III, beta subunit; Region: dnan; TIGR00663 1127134003901 beta-clamp/clamp loader binding surface; other site 1127134003902 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1127134003903 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 1127134003904 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1127134003905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134003906 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1127134003907 DNA-binding interface [nucleotide binding]; DNA binding site 1127134003908 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134003909 putative metal binding site [ion binding]; other site 1127134003910 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1127134003911 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1127134003912 active site 1127134003913 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1127134003914 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1127134003915 glutamine binding [chemical binding]; other site 1127134003916 catalytic triad [active] 1127134003917 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1127134003918 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1127134003919 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1127134003920 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 1127134003921 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1127134003922 putative active site [active] 1127134003923 putative substrate binding site [chemical binding]; other site 1127134003924 ATP binding site [chemical binding]; other site 1127134003925 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1127134003926 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1127134003927 NAD binding site [chemical binding]; other site 1127134003928 catalytic Zn binding site [ion binding]; other site 1127134003929 substrate binding site [chemical binding]; other site 1127134003930 structural Zn binding site [ion binding]; other site 1127134003931 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134003932 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134003933 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1127134003934 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1127134003935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134003936 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134003937 DNA binding residues [nucleotide binding] 1127134003938 dimerization interface [polypeptide binding]; other site 1127134003939 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1127134003940 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1127134003941 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134003942 hydrophobic ligand binding site; other site 1127134003943 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1127134003944 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1127134003945 dimer interface [polypeptide binding]; other site 1127134003946 catalytic triad [active] 1127134003947 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1127134003948 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1127134003949 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1127134003950 dimer interface [polypeptide binding]; other site 1127134003951 TPP-binding site [chemical binding]; other site 1127134003952 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1127134003953 Helix-turn-helix domains; Region: HTH; cl00088 1127134003954 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1127134003955 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134003956 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1127134003957 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1127134003958 dimer interface [polypeptide binding]; other site 1127134003959 active site 1127134003960 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1127134003961 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134003962 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134003963 Helix-turn-helix domains; Region: HTH; cl00088 1127134003964 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134003965 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1127134003966 trimer interface [polypeptide binding]; other site 1127134003967 putative metal binding site [ion binding]; other site 1127134003968 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1127134003969 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 1127134003970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134003971 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1127134003972 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134003973 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134003974 DNA binding residues [nucleotide binding] 1127134003975 CobD/Cbib protein; Region: CobD_Cbib; cl00561 1127134003976 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1127134003977 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1127134003978 hypothetical protein; Provisional; Region: PRK07908 1127134003979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127134003980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134003981 homodimer interface [polypeptide binding]; other site 1127134003982 catalytic residue [active] 1127134003983 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1127134003984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1127134003985 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1127134003986 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1127134003987 active site 1127134003988 DNA binding site [nucleotide binding] 1127134003989 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134003990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134003991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134003992 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1127134003993 active site 1127134003994 GtrA-like protein; Region: GtrA; cl00971 1127134003995 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1127134003996 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1127134003997 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134003998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1127134003999 active site 1127134004000 phosphorylation site [posttranslational modification] 1127134004001 intermolecular recognition site; other site 1127134004002 dimerization interface [polypeptide binding]; other site 1127134004003 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134004004 DNA binding residues [nucleotide binding] 1127134004005 dimerization interface [polypeptide binding]; other site 1127134004006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127134004007 Histidine kinase; Region: HisKA_3; pfam07730 1127134004008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1127134004009 Domain of unknown function (DUF336); Region: DUF336; cl01249 1127134004010 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1127134004011 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1127134004012 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134004013 Cytochrome P450; Region: p450; pfam00067 1127134004014 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1127134004015 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1127134004016 homodimer interface [polypeptide binding]; other site 1127134004017 active site 1127134004018 TDP-binding site; other site 1127134004019 acceptor substrate-binding pocket; other site 1127134004020 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134004021 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1127134004022 Putative zinc ribbon domain; Region: DUF164; pfam02591 1127134004023 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1127134004024 RNA/DNA hybrid binding site [nucleotide binding]; other site 1127134004025 active site 1127134004026 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127134004027 catalytic core [active] 1127134004028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004029 hypothetical protein; Provisional; Region: PRK06753 1127134004030 peptide synthase; Provisional; Region: PRK12467 1127134004031 peptide synthase; Provisional; Region: PRK12467 1127134004032 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134004033 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134004034 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134004035 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134004036 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134004037 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1127134004038 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1127134004039 dimer interface [polypeptide binding]; other site 1127134004040 putative functional site; other site 1127134004041 putative MPT binding site; other site 1127134004042 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134004043 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1127134004044 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134004045 Walker A/P-loop; other site 1127134004046 ATP binding site [chemical binding]; other site 1127134004047 Q-loop/lid; other site 1127134004048 ABC transporter signature motif; other site 1127134004049 Walker B; other site 1127134004050 D-loop; other site 1127134004051 H-loop/switch region; other site 1127134004052 TOBE domain; Region: TOBE_2; cl01440 1127134004053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134004054 putative PBP binding loops; other site 1127134004055 ABC-ATPase subunit interface; other site 1127134004056 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1127134004057 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134004058 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1127134004059 DNA binding residues [nucleotide binding] 1127134004060 TOBE domain; Region: TOBE_2; cl01440 1127134004061 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1127134004062 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134004063 Domain of unknown function (DUF2019); Region: DUF2019; pfam09450 1127134004064 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134004065 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1127134004066 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134004067 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1127134004068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004069 NAD(P) binding site [chemical binding]; other site 1127134004070 active site 1127134004071 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1127134004072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134004073 S-adenosylmethionine binding site [chemical binding]; other site 1127134004074 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1127134004075 DNA binding residues [nucleotide binding] 1127134004076 putative dimer interface [polypeptide binding]; other site 1127134004077 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1127134004078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004079 UreD urease accessory protein; Region: UreD; cl00530 1127134004080 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1127134004081 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134004082 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134004083 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134004084 RNB domain; Region: RNB; pfam00773 1127134004085 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1127134004086 CHAD domain; Region: CHAD; cl10506 1127134004087 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1127134004088 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134004089 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134004090 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1127134004091 oligomerization interface [polypeptide binding]; other site 1127134004092 active site 1127134004093 metal binding site [ion binding]; metal-binding site 1127134004094 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1127134004095 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1127134004096 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134004097 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1127134004098 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1127134004099 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1127134004100 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1127134004101 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1127134004102 metal binding triad; other site 1127134004103 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1127134004104 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1127134004105 metal binding triad; other site 1127134004106 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1127134004107 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1127134004108 putative catalytic site [active] 1127134004109 putative metal binding site [ion binding]; other site 1127134004110 putative phosphate binding site [ion binding]; other site 1127134004111 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 1127134004112 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1127134004113 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134004114 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 1127134004115 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1127134004116 metal binding site [ion binding]; metal-binding site 1127134004117 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1127134004118 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1127134004119 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1127134004120 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1127134004121 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 1127134004122 RDD family; Region: RDD; cl00746 1127134004123 glutamine synthetase, type I; Region: GlnA; TIGR00653 1127134004124 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1127134004125 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1127134004126 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134004127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134004128 Helix-turn-helix domains; Region: HTH; cl00088 1127134004129 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1127134004130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134004131 S-adenosylmethionine binding site [chemical binding]; other site 1127134004132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134004133 DNA-binding site [nucleotide binding]; DNA binding site 1127134004134 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1127134004135 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1127134004136 Walker A/P-loop; other site 1127134004137 ATP binding site [chemical binding]; other site 1127134004138 Q-loop/lid; other site 1127134004139 ABC transporter signature motif; other site 1127134004140 Walker B; other site 1127134004141 D-loop; other site 1127134004142 H-loop/switch region; other site 1127134004143 magnesium transport protein MgtC; Provisional; Region: PRK15385 1127134004144 MgtC family; Region: MgtC; pfam02308 1127134004145 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1127134004146 elongation factor G; Reviewed; Region: PRK12740 1127134004147 G1 box; other site 1127134004148 putative GEF interaction site [polypeptide binding]; other site 1127134004149 GTP/Mg2+ binding site [chemical binding]; other site 1127134004150 Switch I region; other site 1127134004151 G2 box; other site 1127134004152 G3 box; other site 1127134004153 Switch II region; other site 1127134004154 G4 box; other site 1127134004155 G5 box; other site 1127134004156 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1127134004157 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1127134004158 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1127134004159 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1127134004160 Family description; Region: UvrD_C_2; cl15862 1127134004161 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1127134004162 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127134004163 catalytic core [active] 1127134004164 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1127134004165 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1127134004166 putative active site [active] 1127134004167 putative metal binding site [ion binding]; other site 1127134004168 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1127134004169 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134004170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004171 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1127134004172 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1127134004173 catalytic residues [active] 1127134004174 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1127134004175 DNA helicase, putative; Region: TIGR00376 1127134004176 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134004177 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134004178 Family description; Region: UvrD_C_2; cl15862 1127134004179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134004180 S-adenosylmethionine binding site [chemical binding]; other site 1127134004181 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1127134004182 NIPSNAP; Region: NIPSNAP; pfam07978 1127134004183 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1127134004184 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1127134004185 structural tetrad; other site 1127134004186 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1127134004187 structural tetrad; other site 1127134004188 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 1127134004189 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1127134004190 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1127134004191 active site 1127134004192 catalytic site [active] 1127134004193 substrate binding site [chemical binding]; other site 1127134004194 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1127134004195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134004196 ATP binding site [chemical binding]; other site 1127134004197 putative Mg++ binding site [ion binding]; other site 1127134004198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134004199 nucleotide binding region [chemical binding]; other site 1127134004200 ATP-binding site [chemical binding]; other site 1127134004201 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1127134004202 PglZ domain; Region: PglZ; pfam08665 1127134004203 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1127134004204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134004205 Restriction endonuclease; Region: Mrr_cat; cl00516 1127134004206 Protein kinase domain; Region: Pkinase; pfam00069 1127134004207 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134004208 active site 1127134004209 ATP binding site [chemical binding]; other site 1127134004210 substrate binding site [chemical binding]; other site 1127134004211 activation loop (A-loop); other site 1127134004212 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134004213 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134004214 active site 1127134004215 ATP binding site [chemical binding]; other site 1127134004216 substrate binding site [chemical binding]; other site 1127134004217 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134004218 substrate binding site [chemical binding]; other site 1127134004219 activation loop (A-loop); other site 1127134004220 activation loop (A-loop); other site 1127134004221 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1127134004222 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1127134004223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134004224 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134004225 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134004226 active site 1127134004227 ATP binding site [chemical binding]; other site 1127134004228 substrate binding site [chemical binding]; other site 1127134004229 activation loop (A-loop); other site 1127134004230 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1127134004231 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134004232 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1127134004233 Family description; Region: UvrD_C_2; cl15862 1127134004234 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1127134004235 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1127134004236 Predicted esterase [General function prediction only]; Region: COG0627 1127134004237 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134004238 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1127134004239 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1127134004240 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134004241 Walker A/P-loop; other site 1127134004242 ATP binding site [chemical binding]; other site 1127134004243 Q-loop/lid; other site 1127134004244 ABC transporter signature motif; other site 1127134004245 Walker B; other site 1127134004246 D-loop; other site 1127134004247 H-loop/switch region; other site 1127134004248 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1127134004249 NB-ARC domain; Region: NB-ARC; pfam00931 1127134004250 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127134004251 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1127134004252 lipoyl synthase; Provisional; Region: PRK05481 1127134004253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127134004254 FeS/SAM binding site; other site 1127134004255 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1127134004256 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1127134004257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127134004258 Coenzyme A binding pocket [chemical binding]; other site 1127134004259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004260 TIGR01777 family protein; Region: yfcH 1127134004261 NAD(P) binding site [chemical binding]; other site 1127134004262 active site 1127134004263 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1127134004264 E3 interaction surface; other site 1127134004265 lipoyl attachment site [posttranslational modification]; other site 1127134004266 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1127134004267 E3 interaction surface; other site 1127134004268 lipoyl attachment site [posttranslational modification]; other site 1127134004269 e3 binding domain; Region: E3_binding; pfam02817 1127134004270 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1127134004271 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1127134004272 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1127134004273 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1127134004274 interface (dimer of trimers) [polypeptide binding]; other site 1127134004275 Substrate-binding/catalytic site; other site 1127134004276 Zn-binding sites [ion binding]; other site 1127134004277 Helix-turn-helix domains; Region: HTH; cl00088 1127134004278 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1127134004279 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134004280 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1127134004281 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1127134004282 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1127134004283 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1127134004284 homodimer interface [polypeptide binding]; other site 1127134004285 substrate-cofactor binding pocket; other site 1127134004286 catalytic residue [active] 1127134004287 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134004288 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1127134004289 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1127134004290 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1127134004291 putative dimer interface [polypeptide binding]; other site 1127134004292 active site pocket [active] 1127134004293 putative cataytic base [active] 1127134004294 Helix-turn-helix domains; Region: HTH; cl00088 1127134004295 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1127134004296 homotrimer interface [polypeptide binding]; other site 1127134004297 Walker A motif; other site 1127134004298 GTP binding site [chemical binding]; other site 1127134004299 Walker B motif; other site 1127134004300 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1127134004301 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1127134004302 conserved cys residue [active] 1127134004303 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134004304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134004305 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1127134004306 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1127134004307 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1127134004308 substrate binding site [chemical binding]; other site 1127134004309 ATP binding site [chemical binding]; other site 1127134004310 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1127134004311 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1127134004312 dimer interface [polypeptide binding]; other site 1127134004313 active site 1127134004314 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1127134004315 Ligand Binding Site [chemical binding]; other site 1127134004316 Molecular Tunnel; other site 1127134004317 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1127134004318 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 1127134004319 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1127134004320 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1127134004321 FAD binding domain; Region: FAD_binding_4; pfam01565 1127134004322 PhoD-like phosphatase; Region: PhoD; pfam09423 1127134004323 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1127134004324 putative active site [active] 1127134004325 putative metal binding site [ion binding]; other site 1127134004326 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1127134004327 SpoOM protein; Region: Spo0M; pfam07070 1127134004328 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1127134004329 putative acyl-acceptor binding pocket; other site 1127134004330 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1127134004331 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1127134004332 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1127134004333 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1127134004334 P loop; other site 1127134004335 Nucleotide binding site [chemical binding]; other site 1127134004336 DTAP/Switch II; other site 1127134004337 Switch I; other site 1127134004338 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1127134004339 putative hydrophobic ligand binding site [chemical binding]; other site 1127134004340 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134004341 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1127134004342 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1127134004343 NlpC/P60 family; Region: NLPC_P60; cl11438 1127134004344 NlpC/P60 family; Region: NLPC_P60; cl11438 1127134004345 hypothetical protein; Validated; Region: PRK07883 1127134004346 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1127134004347 active site 1127134004348 catalytic site [active] 1127134004349 substrate binding site [chemical binding]; other site 1127134004350 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1127134004351 GIY-YIG motif/motif A; other site 1127134004352 active site 1127134004353 catalytic site [active] 1127134004354 putative DNA binding site [nucleotide binding]; other site 1127134004355 metal binding site [ion binding]; metal-binding site 1127134004356 AsnC family; Region: AsnC_trans_reg; pfam01037 1127134004357 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1127134004358 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1127134004359 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1127134004360 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1127134004361 Subunit I/III interface [polypeptide binding]; other site 1127134004362 Cytochrome c; Region: Cytochrom_C; cl11414 1127134004363 Cytochrome c; Region: Cytochrom_C; cl11414 1127134004364 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1127134004365 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1127134004366 iron-sulfur cluster [ion binding]; other site 1127134004367 [2Fe-2S] cluster binding site [ion binding]; other site 1127134004368 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1127134004369 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1127134004370 heme bH binding site [chemical binding]; other site 1127134004371 Qi binding site; other site 1127134004372 intrachain domain interface; other site 1127134004373 heme bL binding site [chemical binding]; other site 1127134004374 interchain domain interface [polypeptide binding]; other site 1127134004375 Qo binding site; other site 1127134004376 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 1127134004377 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134004378 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134004379 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134004380 active site 1127134004381 ATP binding site [chemical binding]; other site 1127134004382 substrate binding site [chemical binding]; other site 1127134004383 activation loop (A-loop); other site 1127134004384 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1127134004385 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1127134004386 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1127134004387 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1127134004388 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1127134004389 DNA-binding site [nucleotide binding]; DNA binding site 1127134004390 RNA-binding motif; other site 1127134004391 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1127134004392 active site lid residues [active] 1127134004393 substrate binding pocket [chemical binding]; other site 1127134004394 catalytic residues [active] 1127134004395 substrate-Mg2+ binding site; other site 1127134004396 aspartate-rich region 1; other site 1127134004397 aspartate-rich region 2; other site 1127134004398 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1127134004399 phytoene desaturase; Region: crtI_fam; TIGR02734 1127134004400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004401 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1127134004402 substrate binding pocket [chemical binding]; other site 1127134004403 chain length determination region; other site 1127134004404 substrate-Mg2+ binding site; other site 1127134004405 catalytic residues [active] 1127134004406 aspartate-rich region 1; other site 1127134004407 active site lid residues [active] 1127134004408 aspartate-rich region 2; other site 1127134004409 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 1127134004410 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1127134004411 FAD binding site [chemical binding]; other site 1127134004412 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 1127134004413 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1127134004414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1127134004415 active site 1127134004416 Integral membrane protein TerC family; Region: TerC; cl10468 1127134004417 Protein of unknown function (DUF422); Region: DUF422; cl00991 1127134004418 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1127134004419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004421 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134004422 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1127134004423 MraZ protein; Region: MraZ; pfam02381 1127134004424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134004425 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1127134004426 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1127134004427 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1127134004428 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134004429 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1127134004430 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1127134004431 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1127134004432 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1127134004433 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1127134004434 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1127134004435 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1127134004436 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1127134004437 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1127134004438 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1127134004439 Mg++ binding site [ion binding]; other site 1127134004440 putative catalytic motif [active] 1127134004441 putative substrate binding site [chemical binding]; other site 1127134004442 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1127134004443 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1127134004444 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1127134004445 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1127134004446 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1127134004447 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1127134004448 active site 1127134004449 homodimer interface [polypeptide binding]; other site 1127134004450 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1127134004451 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1127134004452 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1127134004453 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1127134004454 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1127134004455 Cell division protein FtsQ; Region: FtsQ; pfam03799 1127134004456 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1127134004457 nucleotide binding site [chemical binding]; other site 1127134004458 SulA interaction site; other site 1127134004459 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1127134004460 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1127134004461 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1127134004462 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1127134004463 catalytic residue [active] 1127134004464 Protein of unknown function (DUF552); Region: DUF552; cl00775 1127134004465 YGGT family; Region: YGGT; cl00508 1127134004466 DivIVA domain; Region: DivI1A_domain; TIGR03544 1127134004467 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1127134004468 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1127134004469 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1127134004470 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1127134004471 HIGH motif; other site 1127134004472 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1127134004473 active site 1127134004474 KMSKS motif; other site 1127134004475 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1127134004476 tRNA binding surface [nucleotide binding]; other site 1127134004477 anticodon binding site; other site 1127134004478 NlpC/P60 family; Region: NLPC_P60; cl11438 1127134004479 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1127134004480 active site 1127134004481 tetramer interface; other site 1127134004482 DNA polymerase IV; Provisional; Region: PRK03348 1127134004483 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1127134004484 active site 1127134004485 DNA binding site [nucleotide binding] 1127134004486 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 1127134004487 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1127134004488 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1127134004489 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1127134004490 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1127134004491 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1127134004492 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1127134004493 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1127134004494 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1127134004495 putative dimer interface [polypeptide binding]; other site 1127134004496 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134004497 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1127134004498 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1127134004499 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1127134004500 RNA binding surface [nucleotide binding]; other site 1127134004501 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1127134004502 active site 1127134004503 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134004504 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1127134004505 dinuclear metal binding motif [ion binding]; other site 1127134004506 classical (c) SDRs; Region: SDR_c; cd05233 1127134004507 short chain dehydrogenase; Provisional; Region: PRK05650 1127134004508 NAD(P) binding site [chemical binding]; other site 1127134004509 active site 1127134004510 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1127134004511 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1127134004512 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1127134004513 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1127134004514 acetyl-CoA synthetase; Provisional; Region: PRK00174 1127134004515 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1127134004516 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134004517 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134004518 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1127134004519 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1127134004520 Na binding site [ion binding]; other site 1127134004521 Protein of unknown function, DUF485; Region: DUF485; cl01231 1127134004522 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1127134004523 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1127134004524 Na binding site [ion binding]; other site 1127134004525 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1127134004526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134004527 active site 1127134004528 phosphorylation site [posttranslational modification] 1127134004529 intermolecular recognition site; other site 1127134004530 dimerization interface [polypeptide binding]; other site 1127134004531 LytTr DNA-binding domain; Region: LytTR; cl04498 1127134004532 Histidine kinase; Region: His_kinase; pfam06580 1127134004533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134004534 ATP binding site [chemical binding]; other site 1127134004535 Mg2+ binding site [ion binding]; other site 1127134004536 G-X-G motif; other site 1127134004537 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 1127134004538 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1127134004539 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1127134004540 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1127134004541 generic binding surface II; other site 1127134004542 generic binding surface I; other site 1127134004543 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134004544 phytoene desaturase; Region: crtI_fam; TIGR02734 1127134004545 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134004546 Predicted ATPase [General function prediction only]; Region: COG3903 1127134004547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134004548 putative substrate translocation pore; other site 1127134004549 Helix-turn-helix domains; Region: HTH; cl00088 1127134004550 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1127134004551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134004552 S-adenosylmethionine binding site [chemical binding]; other site 1127134004553 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1127134004554 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1127134004555 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1127134004556 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1127134004557 catalytic site [active] 1127134004558 active site 1127134004559 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1127134004560 threonine dehydratase; Validated; Region: PRK08639 1127134004561 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1127134004562 tetramer interface [polypeptide binding]; other site 1127134004563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134004564 catalytic residue [active] 1127134004565 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1127134004566 putative Ile/Val binding site [chemical binding]; other site 1127134004567 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134004568 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134004569 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134004570 DNA binding residues [nucleotide binding] 1127134004571 dimerization interface [polypeptide binding]; other site 1127134004572 Helix-turn-helix domains; Region: HTH; cl00088 1127134004573 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1127134004574 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134004575 Walker A/P-loop; other site 1127134004576 ATP binding site [chemical binding]; other site 1127134004577 Q-loop/lid; other site 1127134004578 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1127134004579 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1127134004580 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134004581 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1127134004582 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1127134004583 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1127134004584 active site 1127134004585 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134004586 Cupin domain; Region: Cupin_2; cl09118 1127134004587 Cupin domain; Region: Cupin_2; cl09118 1127134004588 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1127134004589 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1127134004590 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1127134004591 active site 1127134004592 catalytic site [active] 1127134004593 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1127134004594 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1127134004595 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1127134004596 active site 1127134004597 catalytic site [active] 1127134004598 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1127134004599 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127134004600 inhibitor-cofactor binding pocket; inhibition site 1127134004601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134004602 catalytic residue [active] 1127134004603 Cupin domain; Region: Cupin_2; cl09118 1127134004604 Helix-turn-helix domains; Region: HTH; cl00088 1127134004605 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1127134004606 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134004607 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134004608 catalytic residue [active] 1127134004609 AAA domain; Region: AAA_26; pfam13500 1127134004610 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134004611 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134004612 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1127134004613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004614 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1127134004615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134004616 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1127134004617 putative substrate translocation pore; other site 1127134004618 Helix-turn-helix domains; Region: HTH; cl00088 1127134004619 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1127134004620 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1127134004621 putative ligand binding residues [chemical binding]; other site 1127134004622 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1127134004623 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1127134004624 Walker A/P-loop; other site 1127134004625 ATP binding site [chemical binding]; other site 1127134004626 Q-loop/lid; other site 1127134004627 ABC transporter signature motif; other site 1127134004628 Walker B; other site 1127134004629 D-loop; other site 1127134004630 H-loop/switch region; other site 1127134004631 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127134004632 dimer interface [polypeptide binding]; other site 1127134004633 putative PBP binding regions; other site 1127134004634 ABC-ATPase subunit interface; other site 1127134004635 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1127134004636 NMT1-like family; Region: NMT1_2; cl15260 1127134004637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134004638 dimer interface [polypeptide binding]; other site 1127134004639 conserved gate region; other site 1127134004640 putative PBP binding loops; other site 1127134004641 ABC-ATPase subunit interface; other site 1127134004642 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1127134004643 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134004644 Walker A/P-loop; other site 1127134004645 ATP binding site [chemical binding]; other site 1127134004646 Q-loop/lid; other site 1127134004647 ABC transporter signature motif; other site 1127134004648 Walker B; other site 1127134004649 D-loop; other site 1127134004650 H-loop/switch region; other site 1127134004651 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1127134004652 Helix-turn-helix domains; Region: HTH; cl00088 1127134004653 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1127134004654 biotin synthase; Validated; Region: PRK06256 1127134004655 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127134004656 FeS/SAM binding site; other site 1127134004657 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 1127134004658 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1127134004659 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 1127134004660 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1127134004661 nudix motif; other site 1127134004662 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1127134004663 Quinolinate synthetase A protein; Region: NadA; cl00420 1127134004664 L-aspartate oxidase; Provisional; Region: PRK07804 1127134004665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004666 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1127134004667 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1127134004668 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1127134004669 dimerization interface [polypeptide binding]; other site 1127134004670 active site 1127134004671 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1127134004672 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134004673 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134004674 lipid-transfer protein; Provisional; Region: PRK08256 1127134004675 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1127134004676 active site 1127134004677 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1127134004678 active site 1127134004679 catalytic site [active] 1127134004680 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134004681 active site 2 [active] 1127134004682 active site 1 [active] 1127134004683 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1127134004684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004685 NAD(P) binding site [chemical binding]; other site 1127134004686 active site 1127134004687 Helix-turn-helix domains; Region: HTH; cl00088 1127134004688 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134004689 Helix-turn-helix domains; Region: HTH; cl00088 1127134004690 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1127134004691 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134004692 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134004693 YaeQ protein; Region: YaeQ; cl01913 1127134004694 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1127134004695 Helix-turn-helix domains; Region: HTH; cl00088 1127134004696 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1127134004697 dimerization interface [polypeptide binding]; other site 1127134004698 substrate binding pocket [chemical binding]; other site 1127134004699 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1127134004700 active site 1127134004701 catalytic triad [active] 1127134004702 oxyanion hole [active] 1127134004703 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134004704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134004705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004706 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1127134004707 NAD(P) binding site [chemical binding]; other site 1127134004708 active site 1127134004709 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134004710 Helix-turn-helix domains; Region: HTH; cl00088 1127134004711 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1127134004712 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134004713 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134004714 active site 1127134004715 metal binding site [ion binding]; metal-binding site 1127134004716 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1127134004717 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1127134004718 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134004719 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134004720 active site 1127134004721 ATP binding site [chemical binding]; other site 1127134004722 substrate binding site [chemical binding]; other site 1127134004723 activation loop (A-loop); other site 1127134004724 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134004725 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1127134004726 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127134004727 active site 1127134004728 catalytic tetrad [active] 1127134004729 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1127134004730 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1127134004731 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1127134004732 NAD binding site [chemical binding]; other site 1127134004733 dimerization interface [polypeptide binding]; other site 1127134004734 product binding site; other site 1127134004735 substrate binding site [chemical binding]; other site 1127134004736 zinc binding site [ion binding]; other site 1127134004737 catalytic residues [active] 1127134004738 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1127134004739 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127134004740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134004741 homodimer interface [polypeptide binding]; other site 1127134004742 catalytic residue [active] 1127134004743 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 1127134004744 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1127134004745 putative active site pocket [active] 1127134004746 4-fold oligomerization interface [polypeptide binding]; other site 1127134004747 metal binding residues [ion binding]; metal-binding site 1127134004748 3-fold/trimer interface [polypeptide binding]; other site 1127134004749 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1127134004750 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1127134004751 putative active site [active] 1127134004752 oxyanion strand; other site 1127134004753 catalytic triad [active] 1127134004754 Histidine kinase; Region: HisKA_3; pfam07730 1127134004755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134004756 ATP binding site [chemical binding]; other site 1127134004757 Mg2+ binding site [ion binding]; other site 1127134004758 G-X-G motif; other site 1127134004759 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134004760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134004761 active site 1127134004762 phosphorylation site [posttranslational modification] 1127134004763 intermolecular recognition site; other site 1127134004764 dimerization interface [polypeptide binding]; other site 1127134004765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134004766 DNA binding residues [nucleotide binding] 1127134004767 dimerization interface [polypeptide binding]; other site 1127134004768 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 1127134004769 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1127134004770 catalytic residues [active] 1127134004771 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1127134004772 active site 1127134004773 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1127134004774 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1127134004775 substrate binding site [chemical binding]; other site 1127134004776 glutamase interaction surface [polypeptide binding]; other site 1127134004777 acyl-CoA synthetase; Validated; Region: PRK09192 1127134004778 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134004779 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134004780 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127134004781 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1127134004782 active site 1127134004783 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1127134004784 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1127134004785 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1127134004786 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134004787 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134004788 catalytic residue [active] 1127134004789 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 1127134004790 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127134004791 Helix-turn-helix domains; Region: HTH; cl00088 1127134004792 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1127134004793 catalytic triad [active] 1127134004794 anthranilate synthase component I; Provisional; Region: PRK13571 1127134004795 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1127134004796 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1127134004797 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1127134004798 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1127134004799 active site 1127134004800 ribulose/triose binding site [chemical binding]; other site 1127134004801 phosphate binding site [ion binding]; other site 1127134004802 substrate (anthranilate) binding pocket [chemical binding]; other site 1127134004803 product (indole) binding pocket [chemical binding]; other site 1127134004804 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1127134004805 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1127134004806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134004807 catalytic residue [active] 1127134004808 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 1127134004809 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1127134004810 substrate binding site [chemical binding]; other site 1127134004811 active site 1127134004812 catalytic residues [active] 1127134004813 heterodimer interface [polypeptide binding]; other site 1127134004814 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1127134004815 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1127134004816 Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA...; Region: TFIIFa; cl15395 1127134004817 pyruvate kinase; Provisional; Region: PRK06247 1127134004818 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1127134004819 active site 1127134004820 domain interfaces; other site 1127134004821 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1127134004822 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1127134004823 active site 1127134004824 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1127134004825 catalytic triad [active] 1127134004826 dimer interface [polypeptide binding]; other site 1127134004827 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1127134004828 active site 1127134004829 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1127134004830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134004831 Helix-turn-helix domains; Region: HTH; cl00088 1127134004832 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134004833 Helix-turn-helix domains; Region: HTH; cl00088 1127134004834 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1127134004835 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1127134004836 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134004837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134004838 DNA binding residues [nucleotide binding] 1127134004839 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1127134004840 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1127134004841 putative NAD(P) binding site [chemical binding]; other site 1127134004842 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127134004843 Helix-turn-helix domains; Region: HTH; cl00088 1127134004844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134004845 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1127134004846 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1127134004847 dimer interface [polypeptide binding]; other site 1127134004848 active site 1127134004849 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1127134004850 classical (c) SDRs; Region: SDR_c; cd05233 1127134004851 NAD(P) binding site [chemical binding]; other site 1127134004852 active site 1127134004853 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1127134004854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004855 NAD(P) binding site [chemical binding]; other site 1127134004856 active site 1127134004857 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1127134004858 putative active site [active] 1127134004859 putative catalytic site [active] 1127134004860 Secretory lipase; Region: LIP; pfam03583 1127134004861 CHAT domain; Region: CHAT; pfam12770 1127134004862 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1127134004863 structural tetrad; other site 1127134004864 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 1127134004865 nudix motif; other site 1127134004866 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1127134004868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134004869 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134004870 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1127134004871 Int/Topo IB signature motif; other site 1127134004872 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1127134004873 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1127134004874 Walker A/P-loop; other site 1127134004875 ATP binding site [chemical binding]; other site 1127134004876 Q-loop/lid; other site 1127134004877 ABC transporter signature motif; other site 1127134004878 Walker B; other site 1127134004879 D-loop; other site 1127134004880 H-loop/switch region; other site 1127134004881 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1127134004882 Histidine kinase; Region: HisKA_3; pfam07730 1127134004883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134004884 ATP binding site [chemical binding]; other site 1127134004885 Mg2+ binding site [ion binding]; other site 1127134004886 G-X-G motif; other site 1127134004887 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134004888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134004889 active site 1127134004890 phosphorylation site [posttranslational modification] 1127134004891 intermolecular recognition site; other site 1127134004892 dimerization interface [polypeptide binding]; other site 1127134004893 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134004894 DNA binding residues [nucleotide binding] 1127134004895 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134004896 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1127134004897 OpgC protein; Region: OpgC_C; cl00792 1127134004898 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1127134004899 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1127134004900 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1127134004901 Helix-turn-helix domains; Region: HTH; cl00088 1127134004902 Helix-turn-helix domains; Region: HTH; cl00088 1127134004903 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1127134004904 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1127134004905 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1127134004906 Walker A/P-loop; other site 1127134004907 ATP binding site [chemical binding]; other site 1127134004908 Q-loop/lid; other site 1127134004909 ABC transporter signature motif; other site 1127134004910 Walker B; other site 1127134004911 D-loop; other site 1127134004912 H-loop/switch region; other site 1127134004913 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134004914 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134004915 putative metal binding site [ion binding]; other site 1127134004916 Ion channel; Region: Ion_trans_2; cl11596 1127134004917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134004918 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1127134004919 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1127134004920 Na2 binding site [ion binding]; other site 1127134004921 putative substrate binding site 1 [chemical binding]; other site 1127134004922 Na binding site 1 [ion binding]; other site 1127134004923 putative substrate binding site 2 [chemical binding]; other site 1127134004924 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1127134004925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134004926 active site 1127134004927 phosphorylation site [posttranslational modification] 1127134004928 intermolecular recognition site; other site 1127134004929 dimerization interface [polypeptide binding]; other site 1127134004930 ANTAR domain; Region: ANTAR; cl04297 1127134004931 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1127134004932 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1127134004933 dimerization interface [polypeptide binding]; other site 1127134004934 ligand binding site [chemical binding]; other site 1127134004935 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1127134004936 TM-ABC transporter signature motif; other site 1127134004937 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1127134004938 TM-ABC transporter signature motif; other site 1127134004939 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1127134004940 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14702302; Product type t : transporter 1127134004941 Evidence 2b : Function of strongly homologous gene; PubMedId : 14702302; Product type t : transporter 1127134004942 DNA polymerase I; Provisional; Region: PRK05755 1127134004943 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1127134004944 active site 1127134004945 metal binding site 1 [ion binding]; metal-binding site 1127134004946 putative 5' ssDNA interaction site; other site 1127134004947 metal binding site 3; metal-binding site 1127134004948 metal binding site 2 [ion binding]; metal-binding site 1127134004949 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1127134004950 putative DNA binding site [nucleotide binding]; other site 1127134004951 putative metal binding site [ion binding]; other site 1127134004952 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1127134004953 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1127134004954 active site 1127134004955 DNA binding site [nucleotide binding] 1127134004956 catalytic site [active] 1127134004957 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1127134004958 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1127134004959 catalytic residues [active] 1127134004960 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1127134004961 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1127134004962 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1127134004963 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1127134004964 substrate binding pocket [chemical binding]; other site 1127134004965 membrane-bound complex binding site; other site 1127134004966 hinge residues; other site 1127134004967 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1127134004968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134004969 dimer interface [polypeptide binding]; other site 1127134004970 conserved gate region; other site 1127134004971 putative PBP binding loops; other site 1127134004972 ABC-ATPase subunit interface; other site 1127134004973 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1127134004974 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1127134004975 Walker A/P-loop; other site 1127134004976 ATP binding site [chemical binding]; other site 1127134004977 Q-loop/lid; other site 1127134004978 ABC transporter signature motif; other site 1127134004979 Walker B; other site 1127134004980 D-loop; other site 1127134004981 H-loop/switch region; other site 1127134004982 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127134004983 Helix-turn-helix domains; Region: HTH; cl00088 1127134004984 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1127134004985 dimerization interface [polypeptide binding]; other site 1127134004986 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1127134004987 FAD binding domain; Region: FAD_binding_4; pfam01565 1127134004988 Berberine and berberine like; Region: BBE; pfam08031 1127134004989 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1127134004990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1127134004991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134004992 S-adenosylmethionine binding site [chemical binding]; other site 1127134004993 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1127134004994 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1127134004995 RNA binding site [nucleotide binding]; other site 1127134004996 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1127134004997 RNA binding site [nucleotide binding]; other site 1127134004998 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1127134004999 RNA binding site [nucleotide binding]; other site 1127134005000 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1127134005001 RNA binding site [nucleotide binding]; other site 1127134005002 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1127134005003 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1127134005004 ATP-binding [chemical binding]; other site 1127134005005 CoA-binding site [chemical binding]; other site 1127134005006 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 1127134005007 Protein of unknown function (DUF402); Region: DUF402; cl00979 1127134005008 excinuclease ABC subunit B; Provisional; Region: PRK05298 1127134005009 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134005010 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134005011 nucleotide binding region [chemical binding]; other site 1127134005012 ATP-binding site [chemical binding]; other site 1127134005013 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1127134005014 UvrB/uvrC motif; Region: UVR; pfam02151 1127134005015 Helix-turn-helix domains; Region: HTH; cl00088 1127134005016 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1127134005017 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1127134005018 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 1127134005019 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1127134005020 putative dimer interface [polypeptide binding]; other site 1127134005021 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134005022 Helix-turn-helix domain; Region: HTH_18; pfam12833 1127134005023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134005024 DoxX; Region: DoxX; cl00976 1127134005025 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1127134005026 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1127134005027 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134005028 Family description; Region: UvrD_C_2; cl15862 1127134005029 PAS fold; Region: PAS; pfam00989 1127134005030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127134005031 putative active site [active] 1127134005032 heme pocket [chemical binding]; other site 1127134005033 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1127134005034 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1127134005035 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1127134005036 metal binding site [ion binding]; metal-binding site 1127134005037 active site 1127134005038 I-site; other site 1127134005039 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1127134005040 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1127134005041 active site 1127134005042 GAF domain; Region: GAF; cl15785 1127134005043 GAF domain; Region: GAF; cl15785 1127134005044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127134005045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1127134005046 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134005047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134005048 active site 1127134005049 phosphorylation site [posttranslational modification] 1127134005050 intermolecular recognition site; other site 1127134005051 dimerization interface [polypeptide binding]; other site 1127134005052 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134005053 DNA binding residues [nucleotide binding] 1127134005054 dimerization interface [polypeptide binding]; other site 1127134005055 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1127134005056 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1127134005057 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1127134005058 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 1127134005059 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134005060 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134005061 DinB superfamily; Region: DinB_2; pfam12867 1127134005062 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1127134005063 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1127134005064 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 1127134005065 ribosomal protein L20; Region: rpl20; CHL00068 1127134005066 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1127134005067 23S rRNA binding site [nucleotide binding]; other site 1127134005068 L21 binding site [polypeptide binding]; other site 1127134005069 L13 binding site [polypeptide binding]; other site 1127134005070 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1127134005071 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1127134005072 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1127134005073 Helix-turn-helix domains; Region: HTH; cl00088 1127134005074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134005075 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127134005076 putative substrate translocation pore; other site 1127134005077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134005078 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1127134005079 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1127134005080 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1127134005081 dimer interface [polypeptide binding]; other site 1127134005082 motif 1; other site 1127134005083 active site 1127134005084 motif 2; other site 1127134005085 motif 3; other site 1127134005086 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1127134005087 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1127134005088 putative tRNA-binding site [nucleotide binding]; other site 1127134005089 B3/4 domain; Region: B3_4; cl11458 1127134005090 tRNA synthetase B5 domain; Region: B5; cl08394 1127134005091 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1127134005092 dimer interface [polypeptide binding]; other site 1127134005093 motif 1; other site 1127134005094 motif 3; other site 1127134005095 motif 2; other site 1127134005096 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 1127134005097 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134005098 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1127134005099 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134005100 Protein of unknown function (DUF461); Region: DUF461; cl01071 1127134005101 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1127134005102 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1127134005103 conserved cys residue [active] 1127134005104 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134005105 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134005106 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134005107 active site 1127134005108 ATP binding site [chemical binding]; other site 1127134005109 substrate binding site [chemical binding]; other site 1127134005110 activation loop (A-loop); other site 1127134005111 RDD family; Region: RDD; cl00746 1127134005112 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1127134005113 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1127134005114 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1127134005115 maltose O-acetyltransferase; Provisional; Region: PRK10092 1127134005116 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1127134005117 active site 1127134005118 substrate binding site [chemical binding]; other site 1127134005119 trimer interface [polypeptide binding]; other site 1127134005120 CoA binding site [chemical binding]; other site 1127134005121 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 1127134005122 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 1127134005123 Helix-turn-helix domains; Region: HTH; cl00088 1127134005124 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1127134005125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005126 Predicted transcriptional regulator [Transcription]; Region: COG2378 1127134005127 Helix-turn-helix domains; Region: HTH; cl00088 1127134005128 WYL domain; Region: WYL; cl14852 1127134005129 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134005130 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134005131 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134005132 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1127134005133 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134005134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134005135 YCII-related domain; Region: YCII; cl00999 1127134005136 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134005137 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1127134005138 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1127134005139 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1127134005140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005141 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1127134005142 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1127134005143 heterotetramer interface [polypeptide binding]; other site 1127134005144 active site pocket [active] 1127134005145 cleavage site 1127134005146 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1127134005147 feedback inhibition sensing region; other site 1127134005148 homohexameric interface [polypeptide binding]; other site 1127134005149 nucleotide binding site [chemical binding]; other site 1127134005150 N-acetyl-L-glutamate binding site [chemical binding]; other site 1127134005151 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1127134005152 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127134005153 inhibitor-cofactor binding pocket; inhibition site 1127134005154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134005155 catalytic residue [active] 1127134005156 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1127134005157 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1127134005158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005159 arginine repressor; Region: argR_whole; TIGR01529 1127134005160 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1127134005161 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1127134005162 GYD domain; Region: GYD; cl01743 1127134005163 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1127134005164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127134005165 Histidine kinase; Region: HisKA_3; pfam07730 1127134005166 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134005167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134005168 active site 1127134005169 phosphorylation site [posttranslational modification] 1127134005170 intermolecular recognition site; other site 1127134005171 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134005172 DNA binding residues [nucleotide binding] 1127134005173 dimerization interface [polypeptide binding]; other site 1127134005174 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134005175 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 1127134005176 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1127134005177 ANP binding site [chemical binding]; other site 1127134005178 Substrate Binding Site II [chemical binding]; other site 1127134005179 Substrate Binding Site I [chemical binding]; other site 1127134005180 argininosuccinate lyase; Provisional; Region: PRK00855 1127134005181 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1127134005182 active sites [active] 1127134005183 tetramer interface [polypeptide binding]; other site 1127134005184 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1127134005185 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1127134005186 active site 1127134005187 metal binding site [ion binding]; metal-binding site 1127134005188 nudix motif; other site 1127134005189 acyl-CoA synthetase; Validated; Region: PRK07868 1127134005190 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 1127134005191 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134005192 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1127134005193 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1127134005194 inhibitor-cofactor binding pocket; inhibition site 1127134005195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134005196 catalytic residue [active] 1127134005197 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1127134005198 active site 1127134005199 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1127134005200 GtrA-like protein; Region: GtrA; cl00971 1127134005201 Trm112p-like protein; Region: Trm112p; cl01066 1127134005202 Helix-turn-helix domains; Region: HTH; cl00088 1127134005203 transcriptional regulator BetI; Validated; Region: PRK00767 1127134005204 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134005205 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1127134005206 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1127134005207 Walker A/P-loop; other site 1127134005208 ATP binding site [chemical binding]; other site 1127134005209 Q-loop/lid; other site 1127134005210 ABC transporter signature motif; other site 1127134005211 Walker B; other site 1127134005212 D-loop; other site 1127134005213 H-loop/switch region; other site 1127134005214 multicopper oxidase; Provisional; Region: PRK10965 1127134005215 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1127134005216 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1127134005217 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1127134005218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134005219 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1127134005220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134005221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134005222 DNA binding residues [nucleotide binding] 1127134005223 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134005224 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1127134005225 active site 1127134005226 DNA binding site [nucleotide binding] 1127134005227 DoxX; Region: DoxX; cl00976 1127134005228 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1127134005229 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1127134005230 active site 1127134005231 HIGH motif; other site 1127134005232 dimer interface [polypeptide binding]; other site 1127134005233 KMSKS motif; other site 1127134005234 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127134005235 RNA binding surface [nucleotide binding]; other site 1127134005236 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1127134005237 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1127134005238 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1127134005239 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1127134005240 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127134005241 RNA binding surface [nucleotide binding]; other site 1127134005242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134005243 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1127134005244 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 1127134005245 DNA repair protein RecN; Region: recN; TIGR00634 1127134005246 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134005247 Walker A/P-loop; other site 1127134005248 ATP binding site [chemical binding]; other site 1127134005249 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1127134005250 ABC transporter signature motif; other site 1127134005251 Walker B; other site 1127134005252 D-loop; other site 1127134005253 H-loop/switch region; other site 1127134005254 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1127134005255 putative hydrophobic ligand binding site [chemical binding]; other site 1127134005256 protein interface [polypeptide binding]; other site 1127134005257 gate; other site 1127134005258 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1127134005259 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 1127134005260 ATP-binding site [chemical binding]; other site 1127134005261 Gluconate-6-phosphate binding site [chemical binding]; other site 1127134005262 GntP family permease; Region: GntP_permease; pfam02447 1127134005263 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1127134005264 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1127134005265 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 1127134005266 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1127134005267 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1127134005268 CTP synthetase; Validated; Region: pyrG; PRK05380 1127134005269 active site 1127134005270 UTP binding site [chemical binding]; other site 1127134005271 Catalytic site [active] 1127134005272 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1127134005273 active site 1127134005274 putative oxyanion hole; other site 1127134005275 catalytic triad [active] 1127134005276 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1127134005277 dimer interface [polypeptide binding]; other site 1127134005278 active site 1127134005279 ADP-ribose binding site [chemical binding]; other site 1127134005280 nudix motif; other site 1127134005281 metal binding site [ion binding]; metal-binding site 1127134005282 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1127134005283 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1127134005284 active site 1127134005285 Int/Topo IB signature motif; other site 1127134005286 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1127134005287 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1127134005288 P-loop; other site 1127134005289 Magnesium ion binding site [ion binding]; other site 1127134005290 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1127134005291 Magnesium ion binding site [ion binding]; other site 1127134005292 ScpA/B protein; Region: ScpA_ScpB; cl00598 1127134005293 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 1127134005294 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1127134005295 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127134005296 RNA binding surface [nucleotide binding]; other site 1127134005297 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1127134005298 active site 1127134005299 cytidylate kinase; Provisional; Region: cmk; PRK00023 1127134005300 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1127134005301 CMP-binding site; other site 1127134005302 The sites determining sugar specificity; other site 1127134005303 GTP-binding protein Der; Reviewed; Region: PRK03003 1127134005304 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1127134005305 G1 box; other site 1127134005306 GTP/Mg2+ binding site [chemical binding]; other site 1127134005307 Switch I region; other site 1127134005308 G2 box; other site 1127134005309 Switch II region; other site 1127134005310 G3 box; other site 1127134005311 G4 box; other site 1127134005312 G5 box; other site 1127134005313 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1127134005314 G1 box; other site 1127134005315 GTP/Mg2+ binding site [chemical binding]; other site 1127134005316 Switch I region; other site 1127134005317 G2 box; other site 1127134005318 G3 box; other site 1127134005319 Switch II region; other site 1127134005320 G4 box; other site 1127134005321 G5 box; other site 1127134005322 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1127134005323 dimerization domain swap beta strand [polypeptide binding]; other site 1127134005324 regulatory protein interface [polypeptide binding]; other site 1127134005325 active site 1127134005326 regulatory phosphorylation site [posttranslational modification]; other site 1127134005327 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1127134005328 active site 1127134005329 phosphorylation site [posttranslational modification] 1127134005330 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1127134005331 active site 1127134005332 P-loop; other site 1127134005333 phosphorylation site [posttranslational modification] 1127134005334 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1127134005335 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1127134005336 putative substrate binding site [chemical binding]; other site 1127134005337 putative ATP binding site [chemical binding]; other site 1127134005338 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1127134005339 Helix-turn-helix domains; Region: HTH; cl00088 1127134005340 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1127134005341 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1127134005342 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1127134005343 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1127134005344 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1127134005345 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1127134005346 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134005347 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134005348 catalytic residue [active] 1127134005349 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1127134005350 hydroperoxidase II; Provisional; Region: katE; PRK11249 1127134005351 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1127134005352 heme binding pocket [chemical binding]; other site 1127134005353 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1127134005354 domain interactions; other site 1127134005355 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1127134005356 anti sigma factor interaction site; other site 1127134005357 regulatory phosphorylation site [posttranslational modification]; other site 1127134005358 PAS fold; Region: PAS_3; pfam08447 1127134005359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1127134005360 putative active site [active] 1127134005361 heme pocket [chemical binding]; other site 1127134005362 ANTAR domain; Region: ANTAR; cl04297 1127134005363 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1127134005364 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1127134005365 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134005366 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1127134005367 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134005368 DNA binding residues [nucleotide binding] 1127134005369 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1127134005370 Fe-S cluster binding site [ion binding]; other site 1127134005371 active site 1127134005372 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1127134005373 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1127134005374 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1127134005375 active site 1127134005376 metal binding site [ion binding]; metal-binding site 1127134005377 BON domain; Region: BON; cl02771 1127134005378 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 1127134005379 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1127134005380 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1127134005381 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1127134005382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134005383 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127134005384 putative substrate translocation pore; other site 1127134005385 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1127134005386 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1127134005387 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1127134005388 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1127134005389 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134005390 dimerization interface [polypeptide binding]; other site 1127134005391 putative DNA binding site [nucleotide binding]; other site 1127134005392 hypothetical protein; Provisional; Region: PRK08317 1127134005393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134005394 S-adenosylmethionine binding site [chemical binding]; other site 1127134005395 YCII-related domain; Region: YCII; cl00999 1127134005396 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1127134005397 PQQ-like domain; Region: PQQ_2; pfam13360 1127134005398 PQQ-like domain; Region: PQQ_2; pfam13360 1127134005399 Predicted esterase [General function prediction only]; Region: COG0627 1127134005400 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134005401 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134005402 Helix-turn-helix domains; Region: HTH; cl00088 1127134005403 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1127134005404 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127134005405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134005406 homodimer interface [polypeptide binding]; other site 1127134005407 catalytic residue [active] 1127134005408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005409 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1127134005410 NAD(P) binding site [chemical binding]; other site 1127134005411 active site 1127134005412 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1127134005413 Clp amino terminal domain; Region: Clp_N; pfam02861 1127134005414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134005415 Walker A motif; other site 1127134005416 ATP binding site [chemical binding]; other site 1127134005417 Walker B motif; other site 1127134005418 arginine finger; other site 1127134005419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134005420 Walker A motif; other site 1127134005421 ATP binding site [chemical binding]; other site 1127134005422 Walker B motif; other site 1127134005423 arginine finger; other site 1127134005424 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1127134005425 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1127134005426 PhoD-like phosphatase; Region: PhoD; pfam09423 1127134005427 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1127134005428 putative active site [active] 1127134005429 putative metal binding site [ion binding]; other site 1127134005430 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1127134005431 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134005432 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134005433 Helix-turn-helix domains; Region: HTH; cl00088 1127134005434 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134005435 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134005436 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134005437 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1127134005438 FMN binding site [chemical binding]; other site 1127134005439 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1127134005440 substrate binding site [chemical binding]; other site 1127134005441 putative catalytic residue [active] 1127134005442 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 1127134005443 nudix motif; other site 1127134005444 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1127134005445 Short C-terminal domain; Region: SHOCT; cl01373 1127134005446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005447 FAD dependent oxidoreductase; Region: DAO; pfam01266 1127134005448 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1127134005449 [2Fe-2S] cluster binding site [ion binding]; other site 1127134005450 Predicted esterase [General function prediction only]; Region: COG0627 1127134005451 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134005452 Pirin-related protein [General function prediction only]; Region: COG1741 1127134005453 Cupin domain; Region: Cupin_2; cl09118 1127134005454 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1127134005455 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1127134005456 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1127134005457 catalytic residue [active] 1127134005458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127134005459 Helix-turn-helix domains; Region: HTH; cl00088 1127134005460 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1127134005461 putative dimerization interface [polypeptide binding]; other site 1127134005462 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1127134005463 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134005464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134005465 YCII-related domain; Region: YCII; cl00999 1127134005466 Putative cyclase; Region: Cyclase; cl00814 1127134005467 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1127134005468 Helix-turn-helix domains; Region: HTH; cl00088 1127134005469 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1127134005470 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134005471 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1127134005472 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1127134005473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005474 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 1127134005475 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1127134005476 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127134005477 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134005478 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1127134005479 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1127134005480 carboxyltransferase (CT) interaction site; other site 1127134005481 biotinylation site [posttranslational modification]; other site 1127134005482 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1127134005483 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134005484 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134005485 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134005486 active site 1127134005487 metal binding site [ion binding]; metal-binding site 1127134005488 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1127134005489 DNA binding residues [nucleotide binding] 1127134005490 dimer interface [polypeptide binding]; other site 1127134005491 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1127134005492 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 1127134005493 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127134005494 Helix-turn-helix domains; Region: HTH; cl00088 1127134005495 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1127134005496 dimerization interface [polypeptide binding]; other site 1127134005497 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1127134005498 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1127134005499 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1127134005500 putative molybdopterin cofactor binding site [chemical binding]; other site 1127134005501 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1127134005502 putative molybdopterin cofactor binding site; other site 1127134005503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005504 short chain dehydrogenase; Provisional; Region: PRK08278 1127134005505 NAD(P) binding site [chemical binding]; other site 1127134005506 active site 1127134005507 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1127134005508 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134005509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134005510 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1127134005511 transcription termination factor Rho; Provisional; Region: PRK12608 1127134005512 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1127134005513 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134005514 Walker A motif; other site 1127134005515 ATP binding site [chemical binding]; other site 1127134005516 Walker B motif; other site 1127134005517 HEAT repeats; Region: HEAT_2; pfam13646 1127134005518 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1127134005519 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134005520 DNA binding residues [nucleotide binding] 1127134005521 putative dimer interface [polypeptide binding]; other site 1127134005522 HEAT repeats; Region: HEAT_2; pfam13646 1127134005523 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134005524 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1127134005525 substrate binding pocket [chemical binding]; other site 1127134005526 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134005527 DoxX; Region: DoxX; cl00976 1127134005528 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127134005529 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127134005530 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1127134005531 nucleotide binding site [chemical binding]; other site 1127134005532 ethanolamine-phosphate cytidylyltransferase; Provisional; Region: PTZ00308 1127134005533 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1127134005534 active site 1127134005535 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1127134005536 active site 1127134005537 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134005538 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134005539 active site 1127134005540 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1127134005541 classical (c) SDRs; Region: SDR_c; cd05233 1127134005542 NAD(P) binding site [chemical binding]; other site 1127134005543 active site 1127134005544 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 1127134005545 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1127134005546 putative active site [active] 1127134005547 putative substrate binding site [chemical binding]; other site 1127134005548 ATP binding site [chemical binding]; other site 1127134005549 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1127134005550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005551 NAD(P) binding site [chemical binding]; other site 1127134005552 active site 1127134005553 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134005554 active site 1127134005555 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134005556 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134005557 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134005558 active site 1127134005559 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134005560 active site 1127134005561 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1127134005562 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1127134005563 NAD(P) binding site [chemical binding]; other site 1127134005564 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 1127134005565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134005566 motif II; other site 1127134005567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134005568 Helix-turn-helix domains; Region: HTH; cl00088 1127134005569 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1127134005570 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134005571 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134005572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134005573 metabolite-proton symporter; Region: 2A0106; TIGR00883 1127134005574 putative substrate translocation pore; other site 1127134005575 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1127134005576 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1127134005577 dimer interface [polypeptide binding]; other site 1127134005578 active site 1127134005579 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1127134005580 putative active site [active] 1127134005581 putative catalytic site [active] 1127134005582 Secretory lipase; Region: LIP; pfam03583 1127134005583 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1127134005584 classical (c) SDRs; Region: SDR_c; cd05233 1127134005585 NAD(P) binding site [chemical binding]; other site 1127134005586 active site 1127134005587 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1127134005588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134005589 motif II; other site 1127134005590 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1127134005591 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1127134005592 trimer interface [polypeptide binding]; other site 1127134005593 active site 1127134005594 substrate binding site [chemical binding]; other site 1127134005595 CoA binding site [chemical binding]; other site 1127134005596 Predicted membrane protein [Function unknown]; Region: COG2364 1127134005597 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127134005598 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127134005599 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1127134005600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1127134005601 Helix-turn-helix domains; Region: HTH; cl00088 1127134005602 enoyl-CoA hydratase; Provisional; Region: PRK12478 1127134005603 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134005604 substrate binding site [chemical binding]; other site 1127134005605 oxyanion hole (OAH) forming residues; other site 1127134005606 trimer interface [polypeptide binding]; other site 1127134005607 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134005608 AAA domain; Region: AAA_32; pfam13654 1127134005609 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134005610 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1127134005611 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134005612 Walker A/P-loop; other site 1127134005613 ATP binding site [chemical binding]; other site 1127134005614 Q-loop/lid; other site 1127134005615 ABC transporter signature motif; other site 1127134005616 Walker B; other site 1127134005617 D-loop; other site 1127134005618 H-loop/switch region; other site 1127134005619 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1127134005620 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134005621 DNA binding residues [nucleotide binding] 1127134005622 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134005623 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134005624 DNA binding residues [nucleotide binding] 1127134005625 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1127134005626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127134005627 Coenzyme A binding pocket [chemical binding]; other site 1127134005628 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1127134005629 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1127134005630 putative DNA binding site [nucleotide binding]; other site 1127134005631 putative homodimer interface [polypeptide binding]; other site 1127134005632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005633 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 1127134005634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134005635 Helix-turn-helix domains; Region: HTH; cl00088 1127134005636 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1127134005637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134005638 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1127134005639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134005640 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134005641 Cytochrome P450; Region: p450; pfam00067 1127134005642 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134005643 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1127134005644 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1127134005645 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1127134005646 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134005647 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1127134005648 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1127134005649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134005650 Family description; Region: UvrD_C_2; cl15862 1127134005651 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1127134005652 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1127134005653 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134005654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134005655 DNA binding residues [nucleotide binding] 1127134005656 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134005657 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127134005658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005659 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1127134005660 NAD(P) binding site [chemical binding]; other site 1127134005661 active site 1127134005662 peptide synthase; Provisional; Region: PRK09274 1127134005663 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134005664 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1127134005665 active site 1127134005666 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 1127134005667 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1127134005668 active site 1127134005669 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134005670 Helix-turn-helix domains; Region: HTH; cl00088 1127134005671 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134005672 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1127134005673 NAD(P) binding site [chemical binding]; other site 1127134005674 catalytic residues [active] 1127134005675 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1127134005676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005677 NAD(P) binding site [chemical binding]; other site 1127134005678 active site 1127134005679 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1127134005680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134005681 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1127134005682 putative active site [active] 1127134005683 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1127134005684 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1127134005685 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1127134005686 homodimer interface [polypeptide binding]; other site 1127134005687 NADP binding site [chemical binding]; other site 1127134005688 substrate binding site [chemical binding]; other site 1127134005689 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134005690 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1127134005691 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1127134005692 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1127134005693 active site 1127134005694 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1127134005695 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1127134005696 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1127134005697 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1127134005698 EspG family; Region: ESX-1_EspG; pfam14011 1127134005699 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134005700 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1127134005701 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134005702 putative metal binding site [ion binding]; other site 1127134005703 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1127134005704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005705 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1127134005706 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1127134005707 metabolite-proton symporter; Region: 2A0106; TIGR00883 1127134005708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134005709 putative substrate translocation pore; other site 1127134005710 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1127134005711 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134005712 acyl-CoA synthetase; Validated; Region: PRK07788 1127134005713 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134005714 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134005715 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1127134005716 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1127134005717 putative active site [active] 1127134005718 putative metal binding site [ion binding]; other site 1127134005719 acyltransferase PapA5; Provisional; Region: PRK09294 1127134005720 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1127134005721 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1127134005722 FAD binding pocket [chemical binding]; other site 1127134005723 FAD binding motif [chemical binding]; other site 1127134005724 phosphate binding motif [ion binding]; other site 1127134005725 NAD binding pocket [chemical binding]; other site 1127134005726 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1127134005727 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1127134005728 Helix-turn-helix domains; Region: HTH; cl00088 1127134005729 Cupin domain; Region: Cupin_2; cl09118 1127134005730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134005731 putative substrate translocation pore; other site 1127134005732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134005733 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1127134005734 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1127134005735 FAD binding pocket [chemical binding]; other site 1127134005736 FAD binding motif [chemical binding]; other site 1127134005737 phosphate binding motif [ion binding]; other site 1127134005738 beta-alpha-beta structure motif; other site 1127134005739 NAD(p) ribose binding residues [chemical binding]; other site 1127134005740 NAD binding pocket [chemical binding]; other site 1127134005741 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1127134005742 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1127134005743 catalytic loop [active] 1127134005744 iron binding site [ion binding]; other site 1127134005745 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1127134005746 classical (c) SDRs; Region: SDR_c; cd05233 1127134005747 NAD(P) binding site [chemical binding]; other site 1127134005748 active site 1127134005749 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1127134005750 classical (c) SDRs; Region: SDR_c; cd05233 1127134005751 NAD(P) binding site [chemical binding]; other site 1127134005752 active site 1127134005753 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1127134005754 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134005755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134005756 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1127134005757 classical (c) SDRs; Region: SDR_c; cd05233 1127134005758 NAD(P) binding site [chemical binding]; other site 1127134005759 active site 1127134005760 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 1127134005761 ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon; Region: ketosteroid_isomerase; cd00781 1127134005762 dimer interface [polypeptide binding]; other site 1127134005763 active site/substrate binding site [active] 1127134005764 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 1127134005765 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134005766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005767 Flavin Reductases; Region: FlaRed; cl00801 1127134005768 Helix-turn-helix domains; Region: HTH; cl00088 1127134005769 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134005770 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1127134005771 substrate binding pocket [chemical binding]; other site 1127134005772 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1127134005773 Helix-turn-helix domains; Region: HTH; cl00088 1127134005774 Bacterial transcriptional regulator; Region: IclR; pfam01614 1127134005775 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1127134005776 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1127134005777 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1127134005778 active site 1127134005779 Fe binding site [ion binding]; other site 1127134005780 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134005781 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1127134005782 active site 1127134005783 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1127134005784 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1127134005785 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134005786 hydrophobic ligand binding site; other site 1127134005787 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 1127134005788 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1127134005789 classical (c) SDRs; Region: SDR_c; cd05233 1127134005790 NAD(P) binding site [chemical binding]; other site 1127134005791 active site 1127134005792 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134005793 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134005794 active site 2 [active] 1127134005795 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134005796 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134005797 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1127134005798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005799 short chain dehydrogenase; Provisional; Region: PRK06181 1127134005800 NAD(P) binding site [chemical binding]; other site 1127134005801 active site 1127134005802 Domain of unknown function (DUF4324); Region: DUF4324; pfam14212 1127134005803 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134005804 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134005805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134005806 active site 1127134005807 phosphorylation site [posttranslational modification] 1127134005808 intermolecular recognition site; other site 1127134005809 dimerization interface [polypeptide binding]; other site 1127134005810 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134005811 DNA binding residues [nucleotide binding] 1127134005812 dimerization interface [polypeptide binding]; other site 1127134005813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1127134005814 Histidine kinase; Region: HisKA_3; pfam07730 1127134005815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1127134005816 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1127134005817 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1127134005818 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1127134005819 transmembrane helices; other site 1127134005820 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1127134005821 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1127134005822 active site 1127134005823 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1127134005824 Membrane transport protein; Region: Mem_trans; cl09117 1127134005825 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134005826 dimerization interface [polypeptide binding]; other site 1127134005827 putative DNA binding site [nucleotide binding]; other site 1127134005828 putative Zn2+ binding site [ion binding]; other site 1127134005829 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1127134005830 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1127134005831 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134005832 DNA binding residues [nucleotide binding] 1127134005833 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1127134005834 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1127134005835 Domain of unknown function DUF21; Region: DUF21; pfam01595 1127134005836 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1127134005837 Transporter associated domain; Region: CorC_HlyC; cl08393 1127134005838 Domain of unknown function DUF21; Region: DUF21; pfam01595 1127134005839 FOG: CBS domain [General function prediction only]; Region: COG0517 1127134005840 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1127134005841 short chain dehydrogenase; Provisional; Region: PRK12744 1127134005842 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1127134005843 NADP binding site [chemical binding]; other site 1127134005844 homodimer interface [polypeptide binding]; other site 1127134005845 active site 1127134005846 substrate binding site [chemical binding]; other site 1127134005847 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127134005848 Helix-turn-helix domains; Region: HTH; cl00088 1127134005849 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1127134005850 dimerization interface [polypeptide binding]; other site 1127134005851 substrate binding pocket [chemical binding]; other site 1127134005852 short chain dehydrogenase; Provisional; Region: PRK06701 1127134005853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005854 NAD(P) binding site [chemical binding]; other site 1127134005855 active site 1127134005856 Glucose dehydrogenase; Region: glucose_DH; cd08230 1127134005857 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1127134005858 NADP binding site [chemical binding]; other site 1127134005859 catalytic Zn binding site [ion binding]; other site 1127134005860 structural Zn binding site [ion binding]; other site 1127134005861 dimer interface [polypeptide binding]; other site 1127134005862 ChaB; Region: ChaB; cl01887 1127134005863 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 1127134005864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134005865 putative methyltransferase; Provisional; Region: PRK14968 1127134005866 Glyco_18 domain; Region: Glyco_18; smart00636 1127134005867 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134005868 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1127134005869 tetramerization interface [polypeptide binding]; other site 1127134005870 NAD(P) binding site [chemical binding]; other site 1127134005871 catalytic residues [active] 1127134005872 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1127134005873 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1127134005874 NAD(P) binding site [chemical binding]; other site 1127134005875 GAF domain; Region: GAF_2; pfam13185 1127134005876 GAF domain; Region: GAF; cl15785 1127134005877 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1127134005878 Helix-turn-helix domains; Region: HTH; cl00088 1127134005879 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1127134005880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005881 NAD(P) binding site [chemical binding]; other site 1127134005882 active site 1127134005883 short chain dehydrogenase; Provisional; Region: PRK05872 1127134005884 classical (c) SDRs; Region: SDR_c; cd05233 1127134005885 NAD(P) binding site [chemical binding]; other site 1127134005886 active site 1127134005887 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134005888 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1127134005889 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1127134005890 FMN-binding pocket [chemical binding]; other site 1127134005891 flavin binding motif; other site 1127134005892 phosphate binding motif [ion binding]; other site 1127134005893 beta-alpha-beta structure motif; other site 1127134005894 NAD binding pocket [chemical binding]; other site 1127134005895 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1127134005896 catalytic loop [active] 1127134005897 iron binding site [ion binding]; other site 1127134005898 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1127134005899 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1127134005900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134005901 Helix-turn-helix domains; Region: HTH; cl00088 1127134005902 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1127134005903 hydrophobic ligand binding site; other site 1127134005904 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1127134005905 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1127134005906 active site 1127134005907 enoyl-CoA hydratase; Provisional; Region: PRK08252 1127134005908 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134005909 substrate binding site [chemical binding]; other site 1127134005910 oxyanion hole (OAH) forming residues; other site 1127134005911 trimer interface [polypeptide binding]; other site 1127134005912 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134005913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005914 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134005915 DNA binding residues [nucleotide binding] 1127134005916 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1127134005917 Sulfate transporter family; Region: Sulfate_transp; cl15842 1127134005918 Sulfate transporter family; Region: Sulfate_transp; cl15842 1127134005919 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1127134005920 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1127134005921 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1127134005922 DXD motif; other site 1127134005923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005924 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1127134005925 NAD(P) binding site [chemical binding]; other site 1127134005926 active site 1127134005927 Sulfate transporter family; Region: Sulfate_transp; cl15842 1127134005928 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1127134005929 Sulfate transporter family; Region: Sulfate_transp; cl15842 1127134005930 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1127134005931 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1127134005932 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1127134005933 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134005934 SCP-2 sterol transfer family; Region: SCP2; cl01225 1127134005935 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1127134005936 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134005937 DNA binding residues [nucleotide binding] 1127134005938 dimerization interface [polypeptide binding]; other site 1127134005939 Domain of unknown function (DUF389); Region: DUF389; cl00781 1127134005940 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1127134005941 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1127134005942 Sulfate transporter family; Region: Sulfate_transp; cl15842 1127134005943 Sulfate transporter family; Region: Sulfate_transp; cl15842 1127134005944 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1127134005945 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1127134005946 Predicted esterase [General function prediction only]; Region: COG0627 1127134005947 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127134005948 Protein export membrane protein; Region: SecD_SecF; cl14618 1127134005949 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127134005950 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1127134005951 active site 1127134005952 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1127134005953 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1127134005954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005955 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1127134005956 Enoylreductase; Region: PKS_ER; smart00829 1127134005957 NAD(P) binding site [chemical binding]; other site 1127134005958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005959 NAD(P) binding site [chemical binding]; other site 1127134005960 active site 1127134005961 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134005962 Condensation domain; Region: Condensation; pfam00668 1127134005963 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1127134005964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134005965 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127134005966 putative substrate translocation pore; other site 1127134005967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134005968 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1127134005969 pyrimidine utilization protein D; Region: RutD; TIGR03611 1127134005970 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134005971 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1127134005972 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1127134005973 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1127134005974 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1127134005975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005976 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1127134005977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134005978 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1127134005979 active site 1127134005980 catalytic triad [active] 1127134005981 oxyanion hole [active] 1127134005982 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134005983 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1127134005984 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1127134005985 LGFP repeat; Region: LGFP; pfam08310 1127134005986 LGFP repeat; Region: LGFP; pfam08310 1127134005987 Dodecin; Region: Dodecin; cl01328 1127134005988 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1127134005989 FMN binding site [chemical binding]; other site 1127134005990 dimer interface [polypeptide binding]; other site 1127134005991 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1127134005992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005993 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1127134005994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134005995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134005996 Helix-turn-helix domains; Region: HTH; cl00088 1127134005997 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1127134005998 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1127134005999 [4Fe-4S] binding site [ion binding]; other site 1127134006000 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1127134006001 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1127134006002 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1127134006003 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1127134006004 molybdopterin cofactor binding site; other site 1127134006005 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1127134006006 4Fe-4S binding domain; Region: Fer4; cl02805 1127134006007 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1127134006008 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1127134006009 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1127134006010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134006011 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1127134006012 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1127134006013 NMT1-like family; Region: NMT1_2; cl15260 1127134006014 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 1127134006015 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134006016 DNA-binding site [nucleotide binding]; DNA binding site 1127134006017 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1127134006018 UTRA domain; Region: UTRA; cl01230 1127134006019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134006020 Helix-turn-helix domains; Region: HTH; cl00088 1127134006021 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1127134006022 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1127134006023 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134006024 active site 1127134006025 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1127134006026 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134006027 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1127134006028 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1127134006029 CysD dimerization site [polypeptide binding]; other site 1127134006030 G1 box; other site 1127134006031 putative GEF interaction site [polypeptide binding]; other site 1127134006032 GTP/Mg2+ binding site [chemical binding]; other site 1127134006033 Switch I region; other site 1127134006034 G2 box; other site 1127134006035 G3 box; other site 1127134006036 Switch II region; other site 1127134006037 G4 box; other site 1127134006038 G5 box; other site 1127134006039 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1127134006040 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1127134006041 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 1127134006042 ligand-binding site [chemical binding]; other site 1127134006043 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1127134006044 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1127134006045 Active Sites [active] 1127134006046 Helix-turn-helix domains; Region: HTH; cl00088 1127134006047 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1127134006048 classical (c) SDRs; Region: SDR_c; cd05233 1127134006049 NAD(P) binding site [chemical binding]; other site 1127134006050 active site 1127134006051 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 1127134006052 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134006053 CoenzymeA binding site [chemical binding]; other site 1127134006054 subunit interaction site [polypeptide binding]; other site 1127134006055 PHB binding site; other site 1127134006056 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134006057 hydrophobic ligand binding site; other site 1127134006058 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134006059 DinB superfamily; Region: DinB_2; pfam12867 1127134006060 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1127134006061 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1127134006062 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134006063 Walker A/P-loop; other site 1127134006064 ATP binding site [chemical binding]; other site 1127134006065 Q-loop/lid; other site 1127134006066 ABC transporter signature motif; other site 1127134006067 Walker B; other site 1127134006068 D-loop; other site 1127134006069 H-loop/switch region; other site 1127134006070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134006071 DNA-binding site [nucleotide binding]; DNA binding site 1127134006072 FCD domain; Region: FCD; cl11656 1127134006073 2-isopropylmalate synthase; Validated; Region: PRK03739 1127134006074 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1127134006075 active site 1127134006076 catalytic residues [active] 1127134006077 metal binding site [ion binding]; metal-binding site 1127134006078 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1127134006079 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1127134006080 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1127134006081 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1127134006082 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1127134006083 catalytic residues [active] 1127134006084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134006085 S-adenosylmethionine binding site [chemical binding]; other site 1127134006086 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134006087 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134006088 active site 1127134006089 ATP binding site [chemical binding]; other site 1127134006090 substrate binding site [chemical binding]; other site 1127134006091 activation loop (A-loop); other site 1127134006092 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1127134006093 Helix-turn-helix domains; Region: HTH; cl00088 1127134006094 Bacterial transcriptional regulator; Region: IclR; pfam01614 1127134006095 Cutinase; Region: Cutinase; pfam01083 1127134006096 short chain dehydrogenase; Provisional; Region: PRK07201 1127134006097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134006098 NAD(P) binding site [chemical binding]; other site 1127134006099 active site 1127134006100 classical (c) SDRs; Region: SDR_c; cd05233 1127134006101 NAD(P) binding site [chemical binding]; other site 1127134006102 active site 1127134006103 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1127134006104 heme binding pocket [chemical binding]; other site 1127134006105 heme ligand [chemical binding]; other site 1127134006106 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1127134006107 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 1127134006108 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 1127134006109 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134006110 active site 1127134006111 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1127134006112 Restriction endonuclease; Region: Mrr_cat; cl00516 1127134006113 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 1127134006114 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1127134006115 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1127134006116 lipoyl attachment site [posttranslational modification]; other site 1127134006117 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1127134006118 phosphopeptide binding site; other site 1127134006119 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1127134006120 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134006121 DNA binding residues [nucleotide binding] 1127134006122 dimer interface [polypeptide binding]; other site 1127134006123 Bifunctional nuclease; Region: DNase-RNase; cl00553 1127134006124 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1127134006125 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134006126 DNA binding residues [nucleotide binding] 1127134006127 putative dimer interface [polypeptide binding]; other site 1127134006128 glycine dehydrogenase; Provisional; Region: PRK05367 1127134006129 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1127134006130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134006131 tetramer interface [polypeptide binding]; other site 1127134006132 catalytic residue [active] 1127134006133 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1127134006134 tetramer interface [polypeptide binding]; other site 1127134006135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134006136 catalytic residue [active] 1127134006137 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134006138 Helix-turn-helix domains; Region: HTH; cl00088 1127134006139 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 1127134006140 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1127134006141 metal ion-dependent adhesion site (MIDAS); other site 1127134006142 Transcription factor WhiB; Region: Whib; pfam02467 1127134006143 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1127134006144 active site 1127134006145 Electron transfer DM13; Region: DM13; cl02735 1127134006146 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134006147 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134006148 active site 1127134006149 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134006150 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134006151 active site 1127134006152 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1127134006153 active site 1127134006154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134006155 Helix-turn-helix domains; Region: HTH; cl00088 1127134006156 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127134006157 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134006158 Walker A/P-loop; other site 1127134006159 ATP binding site [chemical binding]; other site 1127134006160 Q-loop/lid; other site 1127134006161 ABC transporter signature motif; other site 1127134006162 Walker B; other site 1127134006163 D-loop; other site 1127134006164 H-loop/switch region; other site 1127134006165 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127134006166 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134006167 Walker A/P-loop; other site 1127134006168 ATP binding site [chemical binding]; other site 1127134006169 Q-loop/lid; other site 1127134006170 ABC transporter signature motif; other site 1127134006171 Walker B; other site 1127134006172 D-loop; other site 1127134006173 H-loop/switch region; other site 1127134006174 salicylate synthase; Region: salicyl_syn; TIGR03494 1127134006175 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1127134006176 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134006177 O-methyltransferase; Region: Methyltransf_2; pfam00891 1127134006178 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134006179 Condensation domain; Region: Condensation; pfam00668 1127134006180 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127134006181 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1127134006182 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134006183 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134006184 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134006185 peptide synthase; Provisional; Region: PRK12316 1127134006186 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1127134006187 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134006188 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134006189 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127134006190 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1127134006191 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134006192 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1127134006193 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134006194 Condensation domain; Region: Condensation; pfam00668 1127134006195 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127134006196 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1127134006197 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134006198 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1127134006199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134006200 S-adenosylmethionine binding site [chemical binding]; other site 1127134006201 peptide synthase; Provisional; Region: PRK12467 1127134006202 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134006203 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1127134006204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134006205 NAD(P) binding site [chemical binding]; other site 1127134006206 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 1127134006207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134006208 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134006209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134006210 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1127134006211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134006212 putative substrate translocation pore; other site 1127134006213 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127134006214 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134006215 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1127134006216 active site 1127134006217 cosubstrate binding site; other site 1127134006218 substrate binding site [chemical binding]; other site 1127134006219 catalytic site [active] 1127134006220 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 1127134006221 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1127134006222 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134006223 substrate binding site [chemical binding]; other site 1127134006224 oxyanion hole (OAH) forming residues; other site 1127134006225 trimer interface [polypeptide binding]; other site 1127134006226 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1127134006227 Domain of unknown function (DUF305); Region: DUF305; cl15795 1127134006228 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1127134006229 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134006230 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134006231 active site 1127134006232 Secretory lipase; Region: LIP; pfam03583 1127134006233 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1127134006234 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 1127134006235 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1127134006236 Domain of unknown function DUF21; Region: DUF21; pfam01595 1127134006237 FOG: CBS domain [General function prediction only]; Region: COG0517 1127134006238 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1127134006239 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1127134006240 Domain of unknown function DUF21; Region: DUF21; pfam01595 1127134006241 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1127134006242 Transporter associated domain; Region: CorC_HlyC; cl08393 1127134006243 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1127134006244 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1127134006245 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1127134006246 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1127134006247 active site 1127134006248 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134006249 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1127134006250 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1127134006251 ATP binding site [chemical binding]; other site 1127134006252 Mg++ binding site [ion binding]; other site 1127134006253 motif III; other site 1127134006254 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134006255 nucleotide binding region [chemical binding]; other site 1127134006256 ATP-binding site [chemical binding]; other site 1127134006257 Peptidase family M48; Region: Peptidase_M48; cl12018 1127134006258 Helix-turn-helix domains; Region: HTH; cl00088 1127134006259 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1127134006260 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1127134006261 Walker A/P-loop; other site 1127134006262 ATP binding site [chemical binding]; other site 1127134006263 Q-loop/lid; other site 1127134006264 ABC transporter signature motif; other site 1127134006265 Walker B; other site 1127134006266 D-loop; other site 1127134006267 H-loop/switch region; other site 1127134006268 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1127134006269 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127134006270 ABC-ATPase subunit interface; other site 1127134006271 dimer interface [polypeptide binding]; other site 1127134006272 putative PBP binding regions; other site 1127134006273 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127134006274 ABC-ATPase subunit interface; other site 1127134006275 dimer interface [polypeptide binding]; other site 1127134006276 putative PBP binding regions; other site 1127134006277 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134006278 CoenzymeA binding site [chemical binding]; other site 1127134006279 subunit interaction site [polypeptide binding]; other site 1127134006280 PHB binding site; other site 1127134006281 MMPL family; Region: MMPL; pfam03176 1127134006282 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127134006283 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1127134006284 classical (c) SDRs; Region: SDR_c; cd05233 1127134006285 NAD(P) binding site [chemical binding]; other site 1127134006286 active site 1127134006287 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1127134006288 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1127134006289 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1127134006290 ABC transporter; Region: ABC_tran_2; pfam12848 1127134006291 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1127134006292 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 1127134006293 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134006294 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1127134006295 active site 1127134006296 Helix-turn-helix domains; Region: HTH; cl00088 1127134006297 aconitate hydratase; Validated; Region: PRK09277 1127134006298 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1127134006299 substrate binding site [chemical binding]; other site 1127134006300 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1127134006301 ligand binding site [chemical binding]; other site 1127134006302 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1127134006303 substrate binding site [chemical binding]; other site 1127134006304 NlpC/P60 family; Region: NLPC_P60; cl11438 1127134006305 MoxR-like ATPases [General function prediction only]; Region: COG0714 1127134006306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134006307 Walker A motif; other site 1127134006308 ATP binding site [chemical binding]; other site 1127134006309 Walker B motif; other site 1127134006310 arginine finger; other site 1127134006311 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1127134006312 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1127134006313 hypothetical protein; Provisional; Region: PRK13685 1127134006314 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1127134006315 metal ion-dependent adhesion site (MIDAS); other site 1127134006316 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1127134006317 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1127134006318 NAD(P) binding site [chemical binding]; other site 1127134006319 homotetramer interface [polypeptide binding]; other site 1127134006320 homodimer interface [polypeptide binding]; other site 1127134006321 active site 1127134006322 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1127134006323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134006324 NAD(P) binding site [chemical binding]; other site 1127134006325 active site 1127134006326 ferrochelatase; Reviewed; Region: hemH; PRK00035 1127134006327 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1127134006328 C-terminal domain interface [polypeptide binding]; other site 1127134006329 active site 1127134006330 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1127134006331 active site 1127134006332 N-terminal domain interface [polypeptide binding]; other site 1127134006333 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1127134006334 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1127134006335 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1127134006336 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1127134006337 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1127134006338 active site 1127134006339 catalytic triad [active] 1127134006340 oxyanion hole [active] 1127134006341 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1127134006342 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1127134006343 protein binding site [polypeptide binding]; other site 1127134006344 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1127134006345 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1127134006346 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1127134006347 heterodimer interface [polypeptide binding]; other site 1127134006348 substrate interaction site [chemical binding]; other site 1127134006349 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1127134006350 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1127134006351 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1127134006352 active site 1127134006353 substrate binding site [chemical binding]; other site 1127134006354 coenzyme B12 binding site [chemical binding]; other site 1127134006355 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1127134006356 B12 binding site [chemical binding]; other site 1127134006357 cobalt ligand [ion binding]; other site 1127134006358 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1127134006359 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134006360 GTP/Mg2+ binding site [chemical binding]; other site 1127134006361 G5 box; other site 1127134006362 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1127134006363 Walker A; other site 1127134006364 G1 box; other site 1127134006365 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1127134006366 active site 1127134006367 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1127134006368 active site 1127134006369 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1127134006370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134006371 NAD(P) binding site [chemical binding]; other site 1127134006372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134006373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134006374 active site 1127134006375 active site 1127134006376 short chain dehydrogenase; Validated; Region: PRK05855 1127134006377 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134006378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134006379 Helix-turn-helix domains; Region: HTH; cl00088 1127134006380 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134006381 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134006382 active site 1127134006383 Helix-turn-helix domains; Region: HTH; cl00088 1127134006384 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1127134006385 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1127134006386 conserved cys residue [active] 1127134006387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134006388 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1127134006389 catalytic triad [active] 1127134006390 conserved cis-peptide bond; other site 1127134006391 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1127134006392 nucleotide binding site [chemical binding]; other site 1127134006393 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1127134006394 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1127134006395 active site 1127134006396 DNA binding site [nucleotide binding] 1127134006397 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1127134006398 DNA binding site [nucleotide binding] 1127134006399 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1127134006400 DNA-binding site [nucleotide binding]; DNA binding site 1127134006401 RNA-binding motif; other site 1127134006402 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1127134006403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134006404 Helix-turn-helix domains; Region: HTH; cl00088 1127134006405 peptide synthase; Provisional; Region: PRK12467 1127134006406 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134006407 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127134006408 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1127134006409 active site 1127134006410 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1127134006411 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1127134006412 Helix-turn-helix domains; Region: HTH; cl00088 1127134006413 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134006414 CoenzymeA binding site [chemical binding]; other site 1127134006415 subunit interaction site [polypeptide binding]; other site 1127134006416 PHB binding site; other site 1127134006417 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1127134006418 active site 1127134006419 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1127134006420 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134006421 DNA binding residues [nucleotide binding] 1127134006422 dimer interface [polypeptide binding]; other site 1127134006423 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1127134006424 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1127134006425 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1127134006426 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1127134006427 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134006428 catalytic residue [active] 1127134006429 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1127134006430 active site residue [active] 1127134006431 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1127134006432 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1127134006433 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1127134006434 catalytic residue [active] 1127134006435 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1127134006436 metal-binding site [ion binding] 1127134006437 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1127134006438 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134006439 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134006440 catalytic residue [active] 1127134006441 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134006442 FOG: CBS domain [General function prediction only]; Region: COG0517 1127134006443 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1127134006444 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1127134006445 Helix-turn-helix domains; Region: HTH; cl00088 1127134006446 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134006447 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134006448 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1127134006449 NAD(P) binding site [chemical binding]; other site 1127134006450 putative active site [active] 1127134006451 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1127134006452 Secretory lipase; Region: LIP; pfam03583 1127134006453 Secretory lipase; Region: LIP; pfam03583 1127134006454 Secretory lipase; Region: LIP; pfam03583 1127134006455 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1127134006456 active site 1127134006457 catalytic site [active] 1127134006458 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1127134006459 active site 1127134006460 catalytic site [active] 1127134006461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134006462 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1127134006463 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134006464 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134006465 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1127134006466 homodimer interface [polypeptide binding]; other site 1127134006467 putative substrate binding pocket [chemical binding]; other site 1127134006468 diiron center [ion binding]; other site 1127134006469 Predicted esterase [General function prediction only]; Region: COG0627 1127134006470 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134006471 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1127134006472 active site 1127134006473 catalytic site [active] 1127134006474 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134006475 active site 2 [active] 1127134006476 active site 1 [active] 1127134006477 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1127134006478 putative active site [active] 1127134006479 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134006480 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1127134006481 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1127134006482 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1127134006483 NAD(P) binding site [chemical binding]; other site 1127134006484 Helix-turn-helix domains; Region: HTH; cl00088 1127134006485 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1127134006486 putative dimerization interface [polypeptide binding]; other site 1127134006487 Predicted esterase [General function prediction only]; Region: COG0627 1127134006488 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134006489 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1127134006490 choline dehydrogenase; Validated; Region: PRK02106 1127134006491 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1127134006492 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1127134006493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134006494 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1127134006495 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1127134006496 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134006497 DNA binding residues [nucleotide binding] 1127134006498 dimer interface [polypeptide binding]; other site 1127134006499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134006500 Helix-turn-helix domains; Region: HTH; cl00088 1127134006501 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1127134006502 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134006503 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1127134006504 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1127134006505 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134006506 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1127134006507 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1127134006508 amidase; Provisional; Region: PRK06170 1127134006509 Amidase; Region: Amidase; cl11426 1127134006510 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1127134006511 active site 1127134006512 DNA binding site [nucleotide binding] 1127134006513 Int/Topo IB signature motif; other site 1127134006514 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1127134006515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134006516 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1127134006517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134006518 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1127134006519 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1127134006520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134006521 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134006522 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1127134006523 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1127134006524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134006525 S-adenosylmethionine binding site [chemical binding]; other site 1127134006526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134006527 Helix-turn-helix domains; Region: HTH; cl00088 1127134006528 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1127134006529 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1127134006530 Di-iron ligands [ion binding]; other site 1127134006531 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1127134006532 Rubredoxin; Region: Rubredoxin; pfam00301 1127134006533 iron binding site [ion binding]; other site 1127134006534 Rubredoxin [Energy production and conversion]; Region: COG1773 1127134006535 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1127134006536 iron binding site [ion binding]; other site 1127134006537 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1127134006538 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134006539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134006540 antheraxanthin epoxidase/zeaxanthin epoxidase; Region: PLN02927 1127134006541 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134006542 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1127134006543 CGNR zinc finger; Region: zf-CGNR; pfam11706 1127134006544 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1127134006545 active site 1127134006546 catalytic triad [active] 1127134006547 oxyanion hole [active] 1127134006548 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134006549 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134006550 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134006551 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1127134006552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134006553 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134006554 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1127134006555 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1127134006556 active site 1127134006557 catalytic residues [active] 1127134006558 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1127134006559 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 1127134006560 NAD binding site [chemical binding]; other site 1127134006561 substrate binding site [chemical binding]; other site 1127134006562 catalytic Zn binding site [ion binding]; other site 1127134006563 structural Zn binding site [ion binding]; other site 1127134006564 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1127134006565 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1127134006566 dimer interface [polypeptide binding]; other site 1127134006567 active site 1127134006568 heme binding site [chemical binding]; other site 1127134006569 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1127134006570 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1127134006571 metal binding site 2 [ion binding]; metal-binding site 1127134006572 putative DNA binding helix; other site 1127134006573 metal binding site 1 [ion binding]; metal-binding site 1127134006574 dimer interface [polypeptide binding]; other site 1127134006575 structural Zn2+ binding site [ion binding]; other site 1127134006576 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1127134006577 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134006578 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134006579 Walker A/P-loop; other site 1127134006580 ATP binding site [chemical binding]; other site 1127134006581 Q-loop/lid; other site 1127134006582 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134006583 ABC transporter signature motif; other site 1127134006584 Walker B; other site 1127134006585 D-loop; other site 1127134006586 H-loop/switch region; other site 1127134006587 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134006588 Walker A/P-loop; other site 1127134006589 ATP binding site [chemical binding]; other site 1127134006590 Q-loop/lid; other site 1127134006591 ABC transporter signature motif; other site 1127134006592 Walker B; other site 1127134006593 D-loop; other site 1127134006594 H-loop/switch region; other site 1127134006595 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1127134006596 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134006597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134006598 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127134006599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134006600 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1127134006601 glycerol kinase; Provisional; Region: glpK; PRK00047 1127134006602 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1127134006603 N- and C-terminal domain interface [polypeptide binding]; other site 1127134006604 active site 1127134006605 MgATP binding site [chemical binding]; other site 1127134006606 catalytic site [active] 1127134006607 metal binding site [ion binding]; metal-binding site 1127134006608 carbohydrate binding site [chemical binding]; other site 1127134006609 Helix-turn-helix domains; Region: HTH; cl00088 1127134006610 Bacterial transcriptional regulator; Region: IclR; pfam01614 1127134006611 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1127134006612 glycerol kinase; Region: glycerol_kin; TIGR01311 1127134006613 N- and C-terminal domain interface [polypeptide binding]; other site 1127134006614 active site 1127134006615 MgATP binding site [chemical binding]; other site 1127134006616 catalytic site [active] 1127134006617 metal binding site [ion binding]; metal-binding site 1127134006618 carbohydrate binding site [chemical binding]; other site 1127134006619 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134006620 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134006621 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134006622 DivIVA domain; Region: DivI1A_domain; TIGR03544 1127134006623 DivIVA domain; Region: DivI1A_domain; TIGR03544 1127134006624 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1127134006625 Helix-turn-helix domains; Region: HTH; cl00088 1127134006626 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134006627 substrate binding site [chemical binding]; other site 1127134006628 oxyanion hole (OAH) forming residues; other site 1127134006629 trimer interface [polypeptide binding]; other site 1127134006630 LysE type translocator; Region: LysE; cl00565 1127134006631 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1127134006632 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1127134006633 Walker A/P-loop; other site 1127134006634 ATP binding site [chemical binding]; other site 1127134006635 Q-loop/lid; other site 1127134006636 ABC transporter signature motif; other site 1127134006637 Walker B; other site 1127134006638 D-loop; other site 1127134006639 H-loop/switch region; other site 1127134006640 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127134006641 dimer interface [polypeptide binding]; other site 1127134006642 putative PBP binding regions; other site 1127134006643 ABC-ATPase subunit interface; other site 1127134006644 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1127134006645 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1127134006646 intersubunit interface [polypeptide binding]; other site 1127134006647 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1127134006648 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127134006649 active site 1127134006650 catalytic tetrad [active] 1127134006651 Bacitracin resistance protein BacA; Region: BacA; cl00858 1127134006652 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127134006653 catalytic core [active] 1127134006654 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 1127134006655 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 1127134006656 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1127134006657 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1127134006658 active site 1127134006659 HIGH motif; other site 1127134006660 nucleotide binding site [chemical binding]; other site 1127134006661 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1127134006662 active site 1127134006663 KMSKS motif; other site 1127134006664 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1127134006665 putative tRNA binding surface [nucleotide binding]; other site 1127134006666 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134006667 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1127134006668 active site 1127134006669 catalytic site [active] 1127134006670 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1127134006671 active site 1127134006672 catalytic site [active] 1127134006673 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1127134006674 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 1127134006675 putative active site [active] 1127134006676 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127134006677 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1127134006678 quinone interaction residues [chemical binding]; other site 1127134006679 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 1127134006680 active site 1127134006681 catalytic residues [active] 1127134006682 FMN binding site [chemical binding]; other site 1127134006683 substrate binding site [chemical binding]; other site 1127134006684 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1127134006685 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1127134006686 dimerization interface [polypeptide binding]; other site 1127134006687 active site 1127134006688 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1127134006689 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134006690 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1127134006691 substrate binding site [chemical binding]; other site 1127134006692 hypothetical protein; Provisional; Region: PRK07906 1127134006693 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1127134006694 putative metal binding site [ion binding]; other site 1127134006695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134006696 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 1127134006697 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1127134006698 active site 1127134006699 NTP binding site [chemical binding]; other site 1127134006700 metal binding triad [ion binding]; metal-binding site 1127134006701 Helix-turn-helix domains; Region: HTH; cl00088 1127134006702 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1127134006703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134006704 glutamate dehydrogenase; Provisional; Region: PRK09414 1127134006705 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1127134006706 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1127134006707 NAD(P) binding site [chemical binding]; other site 1127134006708 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1127134006709 NAD-dependent deacetylase; Provisional; Region: PRK05333 1127134006710 Protein of unknown function DUF72; Region: DUF72; cl00777 1127134006711 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1127134006712 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1127134006713 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1127134006714 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1127134006715 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1127134006716 nucleoside/Zn binding site; other site 1127134006717 dimer interface [polypeptide binding]; other site 1127134006718 catalytic motif [active] 1127134006719 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1127134006720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134006721 DNA-binding site [nucleotide binding]; DNA binding site 1127134006722 FCD domain; Region: FCD; cl11656 1127134006723 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1127134006724 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1127134006725 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1127134006726 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1127134006727 hypothetical protein; Provisional; Region: PRK08317 1127134006728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134006729 S-adenosylmethionine binding site [chemical binding]; other site 1127134006730 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1127134006731 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134006732 DNA binding residues [nucleotide binding] 1127134006733 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1127134006734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134006735 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1127134006736 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1127134006737 Amidinotransferase; Region: Amidinotransf; cl12043 1127134006738 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 1127134006739 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1127134006740 Helix-turn-helix domains; Region: HTH; cl00088 1127134006741 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1127134006742 Predicted ATPase [General function prediction only]; Region: COG3899 1127134006743 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134006744 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1127134006745 NAD(P) binding site [chemical binding]; other site 1127134006746 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1127134006747 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134006748 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1127134006749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134006750 NAD(P) binding site [chemical binding]; other site 1127134006751 active site 1127134006752 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1127134006753 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134006754 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1127134006755 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134006756 DNA binding residues [nucleotide binding] 1127134006757 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1127134006758 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1127134006759 proposed catalytic triad [active] 1127134006760 conserved cys residue [active] 1127134006761 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134006762 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134006763 DNA binding residues [nucleotide binding] 1127134006764 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1127134006765 putative dimer interface [polypeptide binding]; other site 1127134006766 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1127134006767 Di-iron ligands [ion binding]; other site 1127134006768 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134006769 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1127134006770 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127134006771 Helix-turn-helix domains; Region: HTH; cl00088 1127134006772 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134006773 Helix-turn-helix domains; Region: HTH; cl00088 1127134006774 WYL domain; Region: WYL; cl14852 1127134006775 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1127134006776 homotrimer interaction site [polypeptide binding]; other site 1127134006777 putative active site [active] 1127134006778 Protein of unknown function (DUF419); Region: DUF419; cl15265 1127134006779 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1127134006780 classical (c) SDRs; Region: SDR_c; cd05233 1127134006781 NAD(P) binding site [chemical binding]; other site 1127134006782 active site 1127134006783 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1127134006784 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1127134006785 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1127134006786 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1127134006787 Helix-turn-helix domains; Region: HTH; cl00088 1127134006788 Bacterial transcriptional regulator; Region: IclR; pfam01614 1127134006789 Predicted ATPase [General function prediction only]; Region: COG3903 1127134006790 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134006791 DNA binding residues [nucleotide binding] 1127134006792 dimerization interface [polypeptide binding]; other site 1127134006793 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1127134006794 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1127134006795 active site 1127134006796 Int/Topo IB signature motif; other site 1127134006797 DNA binding site [nucleotide binding] 1127134006798 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 1127134006799 Helix-turn-helix domains; Region: HTH; cl00088 1127134006800 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 1127134006801 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 1127134006802 active site 1127134006803 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 1127134006804 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 1127134006805 active site 1127134006806 S-adenosylmethionine synthetase [Coenzyme metabolism]; Region: MetK; COG0192 1127134006807 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1127134006808 polymerase nucleotide-binding site; other site 1127134006809 DNA-binding residues [nucleotide binding]; DNA binding site 1127134006810 nucleotide binding site [chemical binding]; other site 1127134006811 primase nucleotide-binding site [nucleotide binding]; other site 1127134006812 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1127134006813 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1127134006814 ParB-like nuclease domain; Region: ParBc; cl02129 1127134006815 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1127134006816 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1127134006817 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1127134006818 dimer interface [polypeptide binding]; other site 1127134006819 ssDNA binding site [nucleotide binding]; other site 1127134006820 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1127134006821 TrwC relaxase; Region: TrwC; pfam08751 1127134006822 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1127134006823 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 1127134006824 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134006825 Family description; Region: UvrD_C_2; cl15862 1127134006826 HTH-like domain; Region: HTH_21; pfam13276 1127134006827 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1127134006828 Integrase core domain; Region: rve; cl01316 1127134006829 Integrase core domain; Region: rve_3; cl15866 1127134006830 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134006831 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054 1127134006832 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 1127134006833 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1127134006834 dsRNA binding site [nucleotide binding]; other site 1127134006835 CHAT domain; Region: CHAT; pfam12770 1127134006836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 1127134006837 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 1127134006838 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 1127134006839 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1127134006840 Trp docking motif [polypeptide binding]; other site 1127134006841 active site 1127134006842 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1127134006843 metal ion-dependent adhesion site (MIDAS); other site 1127134006844 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1127134006845 active site 1127134006846 oxyanion hole [active] 1127134006847 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1127134006848 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1127134006849 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134006850 dimerization interface [polypeptide binding]; other site 1127134006851 putative DNA binding site [nucleotide binding]; other site 1127134006852 putative Zn2+ binding site [ion binding]; other site 1127134006853 Cation efflux family; Region: Cation_efflux; cl00316 1127134006854 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 1127134006855 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1127134006856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134006857 S-adenosylmethionine binding site [chemical binding]; other site 1127134006858 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1127134006859 active site 1127134006860 catalytic residues [active] 1127134006861 DNA binding site [nucleotide binding] 1127134006862 Int/Topo IB signature motif; other site 1127134006863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127134006864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134006865 ATP binding site [chemical binding]; other site 1127134006866 Mg2+ binding site [ion binding]; other site 1127134006867 G-X-G motif; other site 1127134006868 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134006869 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134006870 DNA binding residues [nucleotide binding] 1127134006871 dimerization interface [polypeptide binding]; other site 1127134006872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127134006873 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134006874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1127134006875 active site 1127134006876 phosphorylation site [posttranslational modification] 1127134006877 intermolecular recognition site; other site 1127134006878 dimerization interface [polypeptide binding]; other site 1127134006879 Helix-turn-helix domains; Region: HTH; cl00088 1127134006880 DNA binding residues [nucleotide binding] 1127134006881 dimerization interface [polypeptide binding]; other site 1127134006882 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1127134006883 Protein of unknown function DUF262; Region: DUF262; cl14890 1127134006884 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1127134006885 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1127134006886 MULE transposase domain; Region: MULE; pfam10551 1127134006887 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1127134006888 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1127134006889 putative active site [active] 1127134006890 putative metal-binding site [ion binding]; other site 1127134006891 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1127134006892 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1127134006893 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1127134006894 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1127134006895 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134006896 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1127134006897 Ligand Binding Site [chemical binding]; other site 1127134006898 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1127134006899 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134006900 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 1127134006901 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1127134006902 Ligand Binding Site [chemical binding]; other site 1127134006903 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1127134006904 Ligand Binding Site [chemical binding]; other site 1127134006905 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1127134006906 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1127134006907 Divalent cation transporter; Region: MgtE; cl00786 1127134006908 hypothetical protein; Provisional; Region: PRK07877 1127134006909 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1127134006910 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1127134006911 Ligand Binding Site [chemical binding]; other site 1127134006912 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1127134006913 Ligand Binding Site [chemical binding]; other site 1127134006914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134006915 motif II; other site 1127134006916 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1127134006917 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1127134006918 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1127134006919 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134006920 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127134006921 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1127134006922 Walker A/P-loop; other site 1127134006923 ATP binding site [chemical binding]; other site 1127134006924 Q-loop/lid; other site 1127134006925 ABC transporter signature motif; other site 1127134006926 Walker B; other site 1127134006927 D-loop; other site 1127134006928 H-loop/switch region; other site 1127134006929 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1127134006930 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134006931 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127134006932 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127134006933 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127134006934 binding surface 1127134006935 TPR motif; other site 1127134006936 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127134006937 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127134006938 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127134006939 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1127134006940 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1127134006941 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1127134006942 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1127134006943 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1127134006944 ATP binding site [chemical binding]; other site 1127134006945 substrate binding site [chemical binding]; other site 1127134006946 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1127134006947 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1127134006948 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1127134006949 putative dimer interface [polypeptide binding]; other site 1127134006950 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1127134006951 NAD(P) binding site [chemical binding]; other site 1127134006952 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134006953 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134006954 active site 1127134006955 ATP binding site [chemical binding]; other site 1127134006956 substrate binding site [chemical binding]; other site 1127134006957 activation loop (A-loop); other site 1127134006958 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134006959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134006960 active site 1127134006961 phosphorylation site [posttranslational modification] 1127134006962 intermolecular recognition site; other site 1127134006963 dimerization interface [polypeptide binding]; other site 1127134006964 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134006965 DNA binding residues [nucleotide binding] 1127134006966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127134006967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1127134006968 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1127134006969 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1127134006970 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1127134006971 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1127134006972 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1127134006973 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134006974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134006975 active site 1127134006976 phosphorylation site [posttranslational modification] 1127134006977 intermolecular recognition site; other site 1127134006978 dimerization interface [polypeptide binding]; other site 1127134006979 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134006980 DNA binding residues [nucleotide binding] 1127134006981 dimerization interface [polypeptide binding]; other site 1127134006982 GAF domain; Region: GAF_2; pfam13185 1127134006983 GAF domain; Region: GAF; cl15785 1127134006984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127134006985 Histidine kinase; Region: HisKA_3; pfam07730 1127134006986 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1127134006987 Domain of unknown function DUF302; Region: DUF302; cl01364 1127134006988 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1127134006989 putative homodimer interface [polypeptide binding]; other site 1127134006990 putative homotetramer interface [polypeptide binding]; other site 1127134006991 putative allosteric switch controlling residues; other site 1127134006992 putative metal binding site [ion binding]; other site 1127134006993 putative homodimer-homodimer interface [polypeptide binding]; other site 1127134006994 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1127134006995 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1127134006996 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1127134006997 4Fe-4S binding domain; Region: Fer4; cl02805 1127134006998 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1127134006999 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1127134007000 [4Fe-4S] binding site [ion binding]; other site 1127134007001 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1127134007002 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1127134007003 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1127134007004 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1127134007005 molybdopterin cofactor binding site; other site 1127134007006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134007007 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1127134007008 putative substrate translocation pore; other site 1127134007009 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1127134007010 Domain of unknown function DUF302; Region: DUF302; cl01364 1127134007011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007012 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1127134007013 NAD(P) binding site [chemical binding]; other site 1127134007014 active site 1127134007015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1127134007016 Predicted kinase [General function prediction only]; Region: COG0645 1127134007017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134007018 active site 1127134007019 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1127134007020 hypothetical protein; Provisional; Region: PRK07877 1127134007021 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1127134007022 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134007023 DNA binding residues [nucleotide binding] 1127134007024 dimerization interface [polypeptide binding]; other site 1127134007025 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134007026 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1127134007027 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127134007028 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 1127134007029 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1127134007030 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1127134007031 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1127134007032 Aflatoxin regulatory protein; Region: AflR; pfam08493 1127134007033 Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of...; Region: HX; cl02471 1127134007034 Metal binding sites [ion binding]; metal-binding site 1127134007035 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 1127134007036 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1127134007037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007038 NAD(P) binding site [chemical binding]; other site 1127134007039 active site 1127134007040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134007041 S-adenosylmethionine binding site [chemical binding]; other site 1127134007042 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127134007043 imidazolonepropionase; Region: hutI; TIGR01224 1127134007044 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1127134007045 active site 1127134007046 Cupin domain; Region: Cupin_2; cl09118 1127134007047 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1127134007048 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1127134007049 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134007050 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1127134007051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134007052 Creatinine amidohydrolase; Region: Creatininase; cl00618 1127134007053 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1127134007054 MULE transposase domain; Region: MULE; pfam10551 1127134007055 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127134007056 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1127134007057 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1127134007058 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1127134007059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134007060 ATP binding site [chemical binding]; other site 1127134007061 putative Mg++ binding site [ion binding]; other site 1127134007062 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134007063 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1127134007064 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1127134007065 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1127134007066 Restriction endonuclease; Region: Mrr_cat; cl00516 1127134007067 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1127134007068 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1127134007069 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1127134007070 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1127134007071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134007072 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1127134007073 catalytic residues [active] 1127134007074 catalytic nucleophile [active] 1127134007075 Recombinase; Region: Recombinase; pfam07508 1127134007076 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1127134007077 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134007078 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134007079 active site 1127134007080 Helix-turn-helix domains; Region: HTH; cl00088 1127134007081 Competence-damaged protein; Region: CinA; cl00666 1127134007082 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1127134007083 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1127134007084 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1127134007085 conserved cys residue [active] 1127134007086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134007087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134007088 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134007089 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1127134007090 substrate binding pocket [chemical binding]; other site 1127134007091 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134007092 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134007093 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134007094 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134007095 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127134007096 catalytic core [active] 1127134007097 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1127134007098 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1127134007099 active site 1127134007100 substrate binding site [chemical binding]; other site 1127134007101 Mg2+ binding site [ion binding]; other site 1127134007102 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1127134007103 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1127134007104 4Fe-4S binding domain; Region: Fer4; cl02805 1127134007105 4Fe-4S binding domain; Region: Fer4; cl02805 1127134007106 Cysteine-rich domain; Region: CCG; pfam02754 1127134007107 Cysteine-rich domain; Region: CCG; pfam02754 1127134007108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134007109 Helix-turn-helix domains; Region: HTH; cl00088 1127134007110 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1127134007111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007112 NAD(P) binding site [chemical binding]; other site 1127134007113 active site 1127134007114 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1127134007115 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134007116 substrate binding site [chemical binding]; other site 1127134007117 oxyanion hole (OAH) forming residues; other site 1127134007118 trimer interface [polypeptide binding]; other site 1127134007119 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134007120 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134007121 active site 1127134007122 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1127134007123 active site 1127134007124 dimer interface [polypeptide binding]; other site 1127134007125 motif 1; other site 1127134007126 motif 2; other site 1127134007127 motif 3; other site 1127134007128 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1127134007129 anticodon binding site; other site 1127134007130 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1127134007131 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1127134007132 FMN binding site [chemical binding]; other site 1127134007133 substrate binding site [chemical binding]; other site 1127134007134 putative catalytic residue [active] 1127134007135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007136 FAD dependent oxidoreductase; Region: DAO; pfam01266 1127134007137 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134007138 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134007139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007141 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1127134007142 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134007143 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1127134007144 NAD(P) binding site [chemical binding]; other site 1127134007145 catalytic residues [active] 1127134007146 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1127134007147 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1127134007148 NAD binding site [chemical binding]; other site 1127134007149 catalytic Zn binding site [ion binding]; other site 1127134007150 substrate binding site [chemical binding]; other site 1127134007151 structural Zn binding site [ion binding]; other site 1127134007152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134007153 substrate binding site [chemical binding]; other site 1127134007154 oxyanion hole (OAH) forming residues; other site 1127134007155 trimer interface [polypeptide binding]; other site 1127134007156 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134007157 acyl-CoA synthetase; Validated; Region: PRK08316 1127134007158 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134007159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134007160 Helix-turn-helix domains; Region: HTH; cl00088 1127134007161 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1127134007162 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1127134007163 catalytic triad [active] 1127134007164 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1127134007165 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134007166 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1127134007167 substrate binding pocket [chemical binding]; other site 1127134007168 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134007169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134007170 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1127134007171 classical (c) SDRs; Region: SDR_c; cd05233 1127134007172 NAD(P) binding site [chemical binding]; other site 1127134007173 active site 1127134007174 lipid-transfer protein; Provisional; Region: PRK06059 1127134007175 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1127134007176 active site 1127134007177 DUF35 OB-fold domain; Region: DUF35; pfam01796 1127134007178 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134007179 Switch II region; other site 1127134007180 G4 box; other site 1127134007181 G5 box; other site 1127134007182 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1127134007183 putative active site [active] 1127134007184 putative FMN binding site [chemical binding]; other site 1127134007185 putative substrate binding site [chemical binding]; other site 1127134007186 putative catalytic residue [active] 1127134007187 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127134007188 Helix-turn-helix domains; Region: HTH; cl00088 1127134007189 Cutinase; Region: Cutinase; pfam01083 1127134007190 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134007191 Predicted ATPase [General function prediction only]; Region: COG3903 1127134007192 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134007193 DNA binding residues [nucleotide binding] 1127134007194 dimerization interface [polypeptide binding]; other site 1127134007195 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1127134007196 Helix-turn-helix domains; Region: HTH; cl00088 1127134007197 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 1127134007198 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134007199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134007200 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1127134007201 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134007202 CAAX protease self-immunity; Region: Abi; cl00558 1127134007203 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134007204 DNA binding residues [nucleotide binding] 1127134007205 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134007206 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134007207 active site 1127134007208 ATP binding site [chemical binding]; other site 1127134007209 substrate binding site [chemical binding]; other site 1127134007210 activation loop (A-loop); other site 1127134007211 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134007212 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134007213 active site 1127134007214 metal binding site [ion binding]; metal-binding site 1127134007215 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134007216 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134007217 DNA binding residues [nucleotide binding] 1127134007218 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1127134007219 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1127134007220 active site 1127134007221 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134007222 active site 2 [active] 1127134007223 active site 1 [active] 1127134007224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007225 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1127134007226 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1127134007227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134007228 Helix-turn-helix domains; Region: HTH; cl00088 1127134007229 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1127134007230 YCII-related domain; Region: YCII; cl00999 1127134007231 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1127134007232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134007233 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1127134007234 putative hydrophobic ligand binding site [chemical binding]; other site 1127134007235 Flavin Reductases; Region: FlaRed; cl00801 1127134007236 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1127134007237 DNA-binding site [nucleotide binding]; DNA binding site 1127134007238 RNA-binding motif; other site 1127134007239 Lipase maturation factor; Region: LMF1; pfam06762 1127134007240 BNR repeat-like domain; Region: BNR_2; pfam13088 1127134007241 BNR repeat-like domain; Region: BNR_2; pfam13088 1127134007242 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 1127134007243 Asp-box motif; other site 1127134007244 Ubiquitin-like proteins; Region: UBQ; cl00155 1127134007245 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1127134007246 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1127134007247 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1127134007248 acyl-CoA synthetase; Validated; Region: PRK07788 1127134007249 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134007250 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134007251 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 1127134007252 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1127134007253 putative active site [active] 1127134007254 putative catalytic site [active] 1127134007255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1127134007256 Helix-turn-helix domains; Region: HTH; cl00088 1127134007257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007258 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1127134007259 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1127134007260 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1127134007261 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1127134007262 molybdopterin cofactor binding site; other site 1127134007263 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1127134007264 molybdopterin cofactor binding site; other site 1127134007265 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1127134007266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134007267 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1127134007268 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1127134007269 active site 1127134007270 DNA binding site [nucleotide binding] 1127134007271 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1127134007272 DNA binding site [nucleotide binding] 1127134007273 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1127134007274 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134007275 active site 1127134007276 ATP binding site [chemical binding]; other site 1127134007277 substrate binding site [chemical binding]; other site 1127134007278 activation loop (A-loop); other site 1127134007279 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134007280 P-loop motif; other site 1127134007281 ATP binding site [chemical binding]; other site 1127134007282 Chloramphenicol (Cm) binding site [chemical binding]; other site 1127134007283 catalytic residue [active] 1127134007284 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134007285 DNA binding residues [nucleotide binding] 1127134007286 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 1127134007287 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134007288 DNA binding residues [nucleotide binding] 1127134007289 putative dimer interface [polypeptide binding]; other site 1127134007290 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1127134007291 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1127134007292 oxidoreductase; Provisional; Region: PRK12743 1127134007293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007294 NAD(P) binding site [chemical binding]; other site 1127134007295 active site 1127134007296 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1127134007297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007298 NAD(P) binding site [chemical binding]; other site 1127134007299 active site 1127134007300 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1127134007301 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1127134007302 ATP binding site [chemical binding]; other site 1127134007303 substrate binding site [chemical binding]; other site 1127134007304 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1127134007305 dimer interface [polypeptide binding]; other site 1127134007306 active site 1127134007307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134007308 active site 1127134007309 motif I; other site 1127134007310 motif II; other site 1127134007311 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1127134007312 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1127134007313 putative active site [active] 1127134007314 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1127134007315 classical (c) SDRs; Region: SDR_c; cd05233 1127134007316 NAD(P) binding site [chemical binding]; other site 1127134007317 active site 1127134007318 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1127134007319 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1127134007320 putative ADP-binding pocket [chemical binding]; other site 1127134007321 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1127134007322 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1127134007323 putative active site [active] 1127134007324 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1127134007325 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1127134007326 active site 1127134007327 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1127134007328 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1127134007329 substrate binding site [chemical binding]; other site 1127134007330 ATP binding site [chemical binding]; other site 1127134007331 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1127134007332 active site 1127134007333 nucleotide binding site [chemical binding]; other site 1127134007334 HIGH motif; other site 1127134007335 KMSKS motif; other site 1127134007336 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1127134007337 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1127134007338 D-pathway; other site 1127134007339 Putative ubiquinol binding site [chemical binding]; other site 1127134007340 Low-spin heme (heme b) binding site [chemical binding]; other site 1127134007341 Putative water exit pathway; other site 1127134007342 Binuclear center (heme o3/CuB) [ion binding]; other site 1127134007343 K-pathway; other site 1127134007344 Putative proton exit pathway; other site 1127134007345 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1127134007346 active site 1127134007347 DNA binding site [nucleotide binding] 1127134007348 Int/Topo IB signature motif; other site 1127134007349 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134007350 hydrophobic ligand binding site; other site 1127134007351 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1127134007352 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1127134007353 NAD binding site [chemical binding]; other site 1127134007354 catalytic Zn binding site [ion binding]; other site 1127134007355 structural Zn binding site [ion binding]; other site 1127134007356 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1127134007357 hydrophobic ligand binding site; other site 1127134007358 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1127134007359 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1127134007360 PYR/PP interface [polypeptide binding]; other site 1127134007361 tetramer interface [polypeptide binding]; other site 1127134007362 dimer interface [polypeptide binding]; other site 1127134007363 TPP binding site [chemical binding]; other site 1127134007364 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1127134007365 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1127134007366 TPP-binding site [chemical binding]; other site 1127134007367 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1127134007368 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1127134007369 dimerization interface [polypeptide binding]; other site 1127134007370 DPS ferroxidase diiron center [ion binding]; other site 1127134007371 ion pore; other site 1127134007372 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134007373 Low affinity iron permease; Region: Iron_permease; cl12096 1127134007374 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1127134007375 Helix-turn-helix domains; Region: HTH; cl00088 1127134007376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007377 NAD(P) binding site [chemical binding]; other site 1127134007378 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1127134007379 active site 1127134007380 BCCT family transporter; Region: BCCT; cl00569 1127134007381 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1127134007382 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134007383 NAD(P) binding site [chemical binding]; other site 1127134007384 catalytic residues [active] 1127134007385 choline dehydrogenase; Validated; Region: PRK02106 1127134007386 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1127134007387 Protein of unknown function, DUF488; Region: DUF488; cl01246 1127134007388 RDD family; Region: RDD; cl00746 1127134007389 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134007390 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134007391 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134007392 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134007393 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134007394 active site 1127134007395 ATP binding site [chemical binding]; other site 1127134007396 substrate binding site [chemical binding]; other site 1127134007397 activation loop (A-loop); other site 1127134007398 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1127134007399 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134007400 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1127134007401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134007402 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1127134007403 putative substrate translocation pore; other site 1127134007404 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1127134007405 Helix-turn-helix domains; Region: HTH; cl00088 1127134007406 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1127134007407 putative dimerization interface [polypeptide binding]; other site 1127134007408 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1127134007409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007410 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1127134007411 NAD(P) binding site [chemical binding]; other site 1127134007412 active site 1127134007413 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1127134007414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134007415 S-adenosylmethionine binding site [chemical binding]; other site 1127134007416 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134007417 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1127134007418 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134007419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134007420 Helix-turn-helix domains; Region: HTH; cl00088 1127134007421 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1127134007422 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134007423 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134007424 catalytic residue [active] 1127134007425 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127134007426 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1127134007427 active site 1127134007428 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1127134007429 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1127134007430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007431 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1127134007432 Enoylreductase; Region: PKS_ER; smart00829 1127134007433 NAD(P) binding site [chemical binding]; other site 1127134007434 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1127134007435 putative NADP binding site [chemical binding]; other site 1127134007436 active site 1127134007437 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134007438 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134007439 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1127134007440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134007441 Helix-turn-helix domains; Region: HTH; cl00088 1127134007442 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1127134007443 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1127134007444 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134007445 active site 1127134007446 metal binding site [ion binding]; metal-binding site 1127134007447 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134007448 Helix-turn-helix domains; Region: HTH; cl00088 1127134007449 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134007450 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134007451 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134007452 putative metal binding site [ion binding]; other site 1127134007453 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 1127134007454 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1127134007455 active site 1127134007456 trimer interface [polypeptide binding]; other site 1127134007457 allosteric site; other site 1127134007458 active site lid [active] 1127134007459 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1127134007460 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127134007461 active site 1127134007462 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1127134007463 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1127134007464 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 1127134007465 active site turn [active] 1127134007466 phosphorylation site [posttranslational modification] 1127134007467 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1127134007468 HPr interaction site; other site 1127134007469 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1127134007470 active site 1127134007471 phosphorylation site [posttranslational modification] 1127134007472 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1127134007473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134007474 DNA-binding site [nucleotide binding]; DNA binding site 1127134007475 UTRA domain; Region: UTRA; cl01230 1127134007476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134007477 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1127134007478 putative substrate translocation pore; other site 1127134007479 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1127134007480 Helix-turn-helix domains; Region: HTH; cl00088 1127134007481 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1127134007482 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134007483 non-specific DNA binding site [nucleotide binding]; other site 1127134007484 salt bridge; other site 1127134007485 sequence-specific DNA binding site [nucleotide binding]; other site 1127134007486 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1127134007487 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1127134007488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134007489 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134007490 putative metal binding site [ion binding]; other site 1127134007491 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134007492 dimerization interface [polypeptide binding]; other site 1127134007493 putative DNA binding site [nucleotide binding]; other site 1127134007494 putative Zn2+ binding site [ion binding]; other site 1127134007495 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1127134007496 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1127134007497 BCCT family transporter; Region: BCCT; cl00569 1127134007498 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1127134007499 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1127134007500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007501 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134007502 PhoD-like phosphatase; Region: PhoD; pfam09423 1127134007503 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1127134007504 putative active site [active] 1127134007505 putative metal binding site [ion binding]; other site 1127134007506 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1127134007507 Predicted membrane protein [Function unknown]; Region: COG4425 1127134007508 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1127134007509 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134007510 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1127134007511 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1127134007512 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1127134007513 Protein kinase domain; Region: Pkinase; pfam00069 1127134007514 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134007515 active site 1127134007516 ATP binding site [chemical binding]; other site 1127134007517 substrate binding site [chemical binding]; other site 1127134007518 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134007519 substrate binding site [chemical binding]; other site 1127134007520 activation loop (A-loop); other site 1127134007521 activation loop (A-loop); other site 1127134007522 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127134007523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127134007524 binding surface 1127134007525 TPR motif; other site 1127134007526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134007527 S-adenosylmethionine binding site [chemical binding]; other site 1127134007528 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1127134007529 Cupin domain; Region: Cupin_2; cl09118 1127134007530 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1127134007531 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127134007532 inhibitor-cofactor binding pocket; inhibition site 1127134007533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134007534 catalytic residue [active] 1127134007535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127134007536 Coenzyme A binding pocket [chemical binding]; other site 1127134007537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134007538 ATP binding site [chemical binding]; other site 1127134007539 Mg2+ binding site [ion binding]; other site 1127134007540 G-X-G motif; other site 1127134007541 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127134007542 dimerization interface [polypeptide binding]; other site 1127134007543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127134007544 dimer interface [polypeptide binding]; other site 1127134007545 phosphorylation site [posttranslational modification] 1127134007546 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127134007547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134007548 active site 1127134007549 phosphorylation site [posttranslational modification] 1127134007550 intermolecular recognition site; other site 1127134007551 dimerization interface [polypeptide binding]; other site 1127134007552 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127134007553 DNA binding site [nucleotide binding] 1127134007554 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1127134007555 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1127134007556 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134007557 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1127134007558 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134007559 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1127134007560 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1127134007561 active site 1127134007562 dimer interface [polypeptide binding]; other site 1127134007563 non-prolyl cis peptide bond; other site 1127134007564 insertion regions; other site 1127134007565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007566 active site 1127134007567 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1127134007568 nudix motif; other site 1127134007569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134007570 S-adenosylmethionine binding site [chemical binding]; other site 1127134007571 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1127134007572 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134007573 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1127134007574 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1127134007575 NADP binding site [chemical binding]; other site 1127134007576 putative substrate binding site [chemical binding]; other site 1127134007577 active site 1127134007578 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1127134007579 Helix-turn-helix domains; Region: HTH; cl00088 1127134007580 WHG domain; Region: WHG; pfam13305 1127134007581 Sulfatase; Region: Sulfatase; cl10460 1127134007582 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1127134007583 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1127134007584 Helix-turn-helix domains; Region: HTH; cl00088 1127134007585 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127134007586 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134007587 Walker A/P-loop; other site 1127134007588 ATP binding site [chemical binding]; other site 1127134007589 Q-loop/lid; other site 1127134007590 ABC transporter signature motif; other site 1127134007591 Walker B; other site 1127134007592 D-loop; other site 1127134007593 H-loop/switch region; other site 1127134007594 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127134007595 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1127134007596 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134007597 Walker A/P-loop; other site 1127134007598 ATP binding site [chemical binding]; other site 1127134007599 Q-loop/lid; other site 1127134007600 ABC transporter signature motif; other site 1127134007601 Walker B; other site 1127134007602 D-loop; other site 1127134007603 H-loop/switch region; other site 1127134007604 Helix-turn-helix domains; Region: HTH; cl00088 1127134007605 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1127134007606 Helix-turn-helix domains; Region: HTH; cl00088 1127134007607 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1127134007608 dimerization interface [polypeptide binding]; other site 1127134007609 Protein of unknown function (DUF779); Region: DUF779; cl01432 1127134007610 Helix-turn-helix domains; Region: HTH; cl00088 1127134007611 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1127134007612 Protein of unknown function (DUF419); Region: DUF419; cl15265 1127134007613 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1127134007614 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134007615 NAD(P) binding site [chemical binding]; other site 1127134007616 catalytic residues [active] 1127134007617 Nitrate and nitrite sensing; Region: NIT; pfam08376 1127134007618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134007619 ATP binding site [chemical binding]; other site 1127134007620 Mg2+ binding site [ion binding]; other site 1127134007621 G-X-G motif; other site 1127134007622 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1127134007623 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1127134007624 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1127134007625 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1127134007626 G1 box; other site 1127134007627 GTP/Mg2+ binding site [chemical binding]; other site 1127134007628 G2 box; other site 1127134007629 Switch I region; other site 1127134007630 G3 box; other site 1127134007631 Switch II region; other site 1127134007632 G4 box; other site 1127134007633 G5 box; other site 1127134007634 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1127134007635 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1127134007636 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1127134007637 nudix motif; other site 1127134007638 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134007639 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134007640 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1127134007641 Walker A/P-loop; other site 1127134007642 ATP binding site [chemical binding]; other site 1127134007643 Q-loop/lid; other site 1127134007644 ABC transporter signature motif; other site 1127134007645 Walker B; other site 1127134007646 D-loop; other site 1127134007647 H-loop/switch region; other site 1127134007648 Helix-turn-helix domains; Region: HTH; cl00088 1127134007649 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1127134007650 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1127134007651 Helix-turn-helix domains; Region: HTH; cl00088 1127134007652 DNA polymerase IV; Validated; Region: PRK03858 1127134007653 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1127134007654 active site 1127134007655 DNA binding site [nucleotide binding] 1127134007656 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1127134007657 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1127134007658 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134007659 active site 1127134007660 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1127134007661 AMP binding site [chemical binding]; other site 1127134007662 metal binding site [ion binding]; metal-binding site 1127134007663 active site 1127134007664 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 1127134007665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134007666 Walker A motif; other site 1127134007667 ATP binding site [chemical binding]; other site 1127134007668 Walker B motif; other site 1127134007669 arginine finger; other site 1127134007670 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 1127134007671 multimerization interface [polypeptide binding]; other site 1127134007672 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 1127134007673 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 1127134007674 homodimer interface [polypeptide binding]; other site 1127134007675 active site 1127134007676 heterodimer interface [polypeptide binding]; other site 1127134007677 catalytic residue [active] 1127134007678 metal binding site [ion binding]; metal-binding site 1127134007679 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127134007680 Helix-turn-helix domains; Region: HTH; cl00088 1127134007681 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134007682 dimerization interface [polypeptide binding]; other site 1127134007683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1127134007684 active site 1127134007685 phosphorylation site [posttranslational modification] 1127134007686 intermolecular recognition site; other site 1127134007687 dimerization interface [polypeptide binding]; other site 1127134007688 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1127134007689 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 1127134007690 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1127134007691 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1127134007692 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 1127134007693 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 1127134007694 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1127134007695 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1127134007696 putative dimer interface [polypeptide binding]; other site 1127134007697 [2Fe-2S] cluster binding site [ion binding]; other site 1127134007698 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1127134007699 SLBB domain; Region: SLBB; pfam10531 1127134007700 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 1127134007701 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1127134007702 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1127134007703 catalytic loop [active] 1127134007704 iron binding site [ion binding]; other site 1127134007705 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 1127134007706 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1127134007707 molybdopterin cofactor binding site; other site 1127134007708 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1127134007709 NADH dehydrogenase; Region: NADHdh; cl00469 1127134007710 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1127134007711 4Fe-4S binding domain; Region: Fer4; cl02805 1127134007712 4Fe-4S binding domain; Region: Fer4; cl02805 1127134007713 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 1127134007714 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1127134007715 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1127134007716 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1127134007717 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1127134007718 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1127134007719 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 1127134007720 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1127134007721 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1127134007722 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1127134007723 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1127134007724 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1127134007725 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134007726 Walker A/P-loop; other site 1127134007727 ATP binding site [chemical binding]; other site 1127134007728 Q-loop/lid; other site 1127134007729 ABC transporter signature motif; other site 1127134007730 Walker B; other site 1127134007731 D-loop; other site 1127134007732 H-loop/switch region; other site 1127134007733 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134007734 Walker A/P-loop; other site 1127134007735 ATP binding site [chemical binding]; other site 1127134007736 Q-loop/lid; other site 1127134007737 ABC transporter signature motif; other site 1127134007738 Walker B; other site 1127134007739 D-loop; other site 1127134007740 H-loop/switch region; other site 1127134007741 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1127134007742 Membrane transport protein; Region: Mem_trans; cl09117 1127134007743 Helix-turn-helix domains; Region: HTH; cl00088 1127134007744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134007745 dimerization interface [polypeptide binding]; other site 1127134007746 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1127134007747 classical (c) SDRs; Region: SDR_c; cd05233 1127134007748 NAD(P) binding site [chemical binding]; other site 1127134007749 active site 1127134007750 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1127134007751 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127134007752 dimerization interface [polypeptide binding]; other site 1127134007753 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127134007754 dimer interface [polypeptide binding]; other site 1127134007755 phosphorylation site [posttranslational modification] 1127134007756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134007757 ATP binding site [chemical binding]; other site 1127134007758 Mg2+ binding site [ion binding]; other site 1127134007759 G-X-G motif; other site 1127134007760 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127134007761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134007762 active site 1127134007763 phosphorylation site [posttranslational modification] 1127134007764 intermolecular recognition site; other site 1127134007765 dimerization interface [polypeptide binding]; other site 1127134007766 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127134007767 DNA binding site [nucleotide binding] 1127134007768 Protein of unknown function (DUF461); Region: DUF461; cl01071 1127134007769 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1127134007770 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1127134007771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134007772 S-adenosylmethionine binding site [chemical binding]; other site 1127134007773 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1127134007774 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1127134007775 putative active site [active] 1127134007776 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134007777 dimerization interface [polypeptide binding]; other site 1127134007778 putative DNA binding site [nucleotide binding]; other site 1127134007779 putative Zn2+ binding site [ion binding]; other site 1127134007780 Peptidase family M23; Region: Peptidase_M23; pfam01551 1127134007781 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1127134007782 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1127134007783 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134007784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134007785 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1127134007786 Walker A/P-loop; other site 1127134007787 ATP binding site [chemical binding]; other site 1127134007788 Q-loop/lid; other site 1127134007789 ABC transporter signature motif; other site 1127134007790 Walker B; other site 1127134007791 D-loop; other site 1127134007792 H-loop/switch region; other site 1127134007793 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1127134007794 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134007795 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134007796 peptide synthase; Provisional; Region: PRK12467 1127134007797 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134007798 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134007799 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134007800 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134007801 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134007802 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134007803 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1127134007804 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134007805 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134007806 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134007807 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1127134007808 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1127134007809 putative active site [active] 1127134007810 catalytic triad [active] 1127134007811 putative dimer interface [polypeptide binding]; other site 1127134007812 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1127134007813 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127134007814 active site 1127134007815 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 1127134007816 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134007817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134007818 active site 1127134007819 phosphorylation site [posttranslational modification] 1127134007820 intermolecular recognition site; other site 1127134007821 dimerization interface [polypeptide binding]; other site 1127134007822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134007823 DNA binding residues [nucleotide binding] 1127134007824 dimerization interface [polypeptide binding]; other site 1127134007825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127134007826 Histidine kinase; Region: HisKA_3; pfam07730 1127134007827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134007828 ATP binding site [chemical binding]; other site 1127134007829 Mg2+ binding site [ion binding]; other site 1127134007830 G-X-G motif; other site 1127134007831 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1127134007832 Helix-turn-helix domains; Region: HTH; cl00088 1127134007833 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1127134007834 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 1127134007835 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 1127134007836 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 1127134007837 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 1127134007838 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1127134007839 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1127134007840 NAD binding site [chemical binding]; other site 1127134007841 substrate binding site [chemical binding]; other site 1127134007842 homodimer interface [polypeptide binding]; other site 1127134007843 active site 1127134007844 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134007845 Helix-turn-helix domains; Region: HTH; cl00088 1127134007846 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134007847 active site 1127134007848 metal binding site [ion binding]; metal-binding site 1127134007849 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134007850 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1127134007851 active site 1127134007852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134007853 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134007854 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1127134007855 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1127134007856 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1127134007857 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1127134007858 NAD(P) binding site [chemical binding]; other site 1127134007859 substrate binding site [chemical binding]; other site 1127134007860 dimer interface [polypeptide binding]; other site 1127134007861 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1127134007862 GXWXG protein; Region: GXWXG; pfam14231 1127134007863 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1127134007864 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1127134007865 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1127134007866 catalytic Zn binding site [ion binding]; other site 1127134007867 NAD binding site [chemical binding]; other site 1127134007868 structural Zn binding site [ion binding]; other site 1127134007869 Helix-turn-helix domain; Region: HTH_18; pfam12833 1127134007870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134007871 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134007872 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134007873 dimerization interface [polypeptide binding]; other site 1127134007874 putative DNA binding site [nucleotide binding]; other site 1127134007875 putative Zn2+ binding site [ion binding]; other site 1127134007876 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134007877 hydrophobic ligand binding site; other site 1127134007878 precorrin-3B synthase; Region: CobG; TIGR02435 1127134007879 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1127134007880 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 1127134007881 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1127134007882 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1127134007883 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1127134007884 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1127134007885 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1127134007886 Helix-turn-helix domains; Region: HTH; cl00088 1127134007887 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1127134007888 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134007889 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1127134007890 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1127134007891 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1127134007892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134007893 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 1127134007894 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1127134007895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007896 NAD(P) binding site [chemical binding]; other site 1127134007897 active site 1127134007898 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134007899 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1127134007900 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1127134007901 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1127134007902 active site 1127134007903 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1127134007904 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1127134007905 active site 1127134007906 metal binding site 1 [ion binding]; metal-binding site 1127134007907 putative 5' ssDNA interaction site; other site 1127134007908 metal binding site 3; metal-binding site 1127134007909 metal binding site 2 [ion binding]; metal-binding site 1127134007910 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1127134007911 putative DNA binding site [nucleotide binding]; other site 1127134007912 putative metal binding site [ion binding]; other site 1127134007913 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1127134007914 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1127134007915 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134007916 ATP binding site [chemical binding]; other site 1127134007917 putative Mg++ binding site [ion binding]; other site 1127134007918 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134007919 ATP-binding site [chemical binding]; other site 1127134007920 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 1127134007921 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1127134007922 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1127134007923 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1127134007924 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 1127134007925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007926 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1127134007927 Predicted transcriptional regulator [Transcription]; Region: COG2378 1127134007928 WYL domain; Region: WYL; cl14852 1127134007929 Predicted transcriptional regulator [Transcription]; Region: COG2378 1127134007930 WYL domain; Region: WYL; cl14852 1127134007931 Domain of unknown function DUF77; Region: DUF77; cl00307 1127134007932 Pup-ligase protein; Region: Pup_ligase; cl15463 1127134007933 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1127134007934 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1127134007935 active site 1127134007936 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1127134007937 active site 1127134007938 Pup-like protein; Region: Pup; cl05289 1127134007939 Pup-ligase protein; Region: Pup_ligase; cl15463 1127134007940 Predicted membrane protein [Function unknown]; Region: COG2311 1127134007941 Protein of unknown function (DUF418); Region: DUF418; cl12135 1127134007942 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1127134007943 CGNR zinc finger; Region: zf-CGNR; pfam11706 1127134007944 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1127134007945 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1127134007946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134007947 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1127134007948 Helix-turn-helix domains; Region: HTH; cl00088 1127134007949 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134007950 CoenzymeA binding site [chemical binding]; other site 1127134007951 subunit interaction site [polypeptide binding]; other site 1127134007952 PHB binding site; other site 1127134007953 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1127134007954 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134007955 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1127134007956 nudix motif; other site 1127134007957 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 1127134007958 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1127134007959 ArsC family; Region: ArsC; pfam03960 1127134007960 catalytic residues [active] 1127134007961 proteasome ATPase; Region: pup_AAA; TIGR03689 1127134007962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134007963 Walker A motif; other site 1127134007964 ATP binding site [chemical binding]; other site 1127134007965 Walker B motif; other site 1127134007966 arginine finger; other site 1127134007967 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1127134007968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134007969 S-adenosylmethionine binding site [chemical binding]; other site 1127134007970 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1127134007971 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1127134007972 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1127134007973 ATP phosphoribosyltransferase; Region: HisG; cl15266 1127134007974 HisG, C-terminal domain; Region: HisG_C; cl06867 1127134007975 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1127134007976 homodimer interface [polypeptide binding]; other site 1127134007977 putative metal binding site [ion binding]; other site 1127134007978 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 1127134007979 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1127134007980 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1127134007981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134007982 motif II; other site 1127134007983 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134007984 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134007985 active site 1127134007986 ATP binding site [chemical binding]; other site 1127134007987 substrate binding site [chemical binding]; other site 1127134007988 activation loop (A-loop); other site 1127134007989 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1127134007990 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1127134007991 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1127134007992 substrate binding pocket [chemical binding]; other site 1127134007993 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1127134007994 B12 binding site [chemical binding]; other site 1127134007995 cobalt ligand [ion binding]; other site 1127134007996 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1127134007997 PAC2 family; Region: PAC2; cl00847 1127134007998 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 1127134007999 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 1127134008000 TIGR02680 family protein; Region: TIGR02680 1127134008001 TIGR02680 family protein; Region: TIGR02680 1127134008002 TIGR02680 family protein; Region: TIGR02680 1127134008003 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1127134008004 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127134008005 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134008006 non-specific DNA binding site [nucleotide binding]; other site 1127134008007 salt bridge; other site 1127134008008 sequence-specific DNA binding site [nucleotide binding]; other site 1127134008009 Flavoprotein; Region: Flavoprotein; cl08021 1127134008010 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1127134008011 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1127134008012 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134008013 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134008014 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 1127134008015 fumarate hydratase; Provisional; Region: PRK15389 1127134008016 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 1127134008017 Fumarase C-terminus; Region: Fumerase_C; cl00795 1127134008018 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1127134008019 Helix-turn-helix domains; Region: HTH; cl00088 1127134008020 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1127134008021 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1127134008022 phosphate binding site [ion binding]; other site 1127134008023 Creatinine amidohydrolase; Region: Creatininase; cl00618 1127134008024 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1127134008025 Helix-turn-helix domains; Region: HTH; cl00088 1127134008026 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1127134008027 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1127134008028 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1127134008029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1127134008030 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1127134008031 PAS domain S-box; Region: sensory_box; TIGR00229 1127134008032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127134008033 putative active site [active] 1127134008034 heme pocket [chemical binding]; other site 1127134008035 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1127134008036 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1127134008037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1127134008038 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1127134008039 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1127134008040 anti sigma factor interaction site; other site 1127134008041 regulatory phosphorylation site [posttranslational modification]; other site 1127134008042 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1127134008043 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1127134008044 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 1127134008045 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1127134008046 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1127134008047 putative ADP-binding pocket [chemical binding]; other site 1127134008048 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 1127134008049 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1127134008050 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1127134008051 hypothetical protein; Provisional; Region: PRK07877 1127134008052 FMN binding site [chemical binding]; other site 1127134008053 dimer interface [polypeptide binding]; other site 1127134008054 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1127134008055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134008056 Walker A/P-loop; other site 1127134008057 ATP binding site [chemical binding]; other site 1127134008058 Q-loop/lid; other site 1127134008059 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1127134008060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134008061 Walker A/P-loop; other site 1127134008062 ATP binding site [chemical binding]; other site 1127134008063 Q-loop/lid; other site 1127134008064 ABC transporter signature motif; other site 1127134008065 Walker B; other site 1127134008066 D-loop; other site 1127134008067 H-loop/switch region; other site 1127134008068 Helix-turn-helix domains; Region: HTH; cl00088 1127134008069 Predicted transcriptional regulator [Transcription]; Region: COG2378 1127134008070 WYL domain; Region: WYL; cl14852 1127134008071 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 1127134008072 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134008073 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134008074 Walker B; other site 1127134008075 D-loop; other site 1127134008076 H-loop/switch region; other site 1127134008077 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1127134008078 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134008079 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134008080 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134008081 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134008082 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134008083 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134008084 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1127134008085 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1127134008086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1127134008087 CHAT domain; Region: CHAT; pfam12770 1127134008088 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134008089 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1127134008090 Domain of unknown function DUF59; Region: DUF59; cl00941 1127134008091 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1127134008092 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1127134008093 trimerization site [polypeptide binding]; other site 1127134008094 active site 1127134008095 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1127134008096 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1127134008097 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134008098 catalytic residue [active] 1127134008099 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1127134008100 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 1127134008101 Walker A/P-loop; other site 1127134008102 ATP binding site [chemical binding]; other site 1127134008103 Q-loop/lid; other site 1127134008104 ABC transporter signature motif; other site 1127134008105 Walker B; other site 1127134008106 D-loop; other site 1127134008107 H-loop/switch region; other site 1127134008108 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1127134008109 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1127134008110 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1127134008111 FeS assembly protein SufB; Region: sufB; TIGR01980 1127134008112 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134008113 Predicted transcriptional regulator [Transcription]; Region: COG2345 1127134008114 putative DNA binding site [nucleotide binding]; other site 1127134008115 putative Zn2+ binding site [ion binding]; other site 1127134008116 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1127134008117 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127134008118 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1127134008119 Walker A/P-loop; other site 1127134008120 ATP binding site [chemical binding]; other site 1127134008121 Q-loop/lid; other site 1127134008122 ABC transporter signature motif; other site 1127134008123 Walker B; other site 1127134008124 D-loop; other site 1127134008125 H-loop/switch region; other site 1127134008126 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134008127 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1127134008128 OsmC-like protein; Region: OsmC; cl00767 1127134008129 Helix-turn-helix domains; Region: HTH; cl00088 1127134008130 Helix-turn-helix domains; Region: HTH; cl00088 1127134008131 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1127134008132 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1127134008133 NADP binding site [chemical binding]; other site 1127134008134 dimer interface [polypeptide binding]; other site 1127134008135 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134008136 Helix-turn-helix domains; Region: HTH; cl00088 1127134008137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008138 hypothetical protein; Provisional; Region: PRK06184 1127134008139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134008141 UbiA prenyltransferase family; Region: UbiA; cl00337 1127134008142 transketolase; Reviewed; Region: PRK05899 1127134008143 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1127134008144 TPP-binding site [chemical binding]; other site 1127134008145 dimer interface [polypeptide binding]; other site 1127134008146 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1127134008147 PYR/PP interface [polypeptide binding]; other site 1127134008148 dimer interface [polypeptide binding]; other site 1127134008149 TPP binding site [chemical binding]; other site 1127134008150 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1127134008151 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1127134008152 putative active site [active] 1127134008153 transaldolase; Provisional; Region: PRK03903 1127134008154 catalytic residue [active] 1127134008155 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1127134008156 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1127134008157 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1127134008158 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1127134008159 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 1127134008160 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1127134008161 putative active site [active] 1127134008162 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1127134008163 putative deacylase active site [active] 1127134008164 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1127134008165 TPP-binding site [chemical binding]; other site 1127134008166 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1127134008167 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1127134008168 PYR/PP interface [polypeptide binding]; other site 1127134008169 dimer interface [polypeptide binding]; other site 1127134008170 TPP binding site [chemical binding]; other site 1127134008171 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1127134008172 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134008173 hydrophobic ligand binding site; other site 1127134008174 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1127134008175 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134008176 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1127134008177 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134008178 DNA binding residues [nucleotide binding] 1127134008179 dimerization interface [polypeptide binding]; other site 1127134008180 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1127134008181 active site 1127134008182 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 1127134008183 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134008184 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1127134008185 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1127134008186 EspG family; Region: ESX-1_EspG; pfam14011 1127134008187 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1127134008188 Moco binding site; other site 1127134008189 metal coordination site [ion binding]; other site 1127134008190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134008191 Helix-turn-helix domains; Region: HTH; cl00088 1127134008192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134008193 S-adenosylmethionine binding site [chemical binding]; other site 1127134008194 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134008195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008196 short chain dehydrogenase; Provisional; Region: PRK08278 1127134008197 NAD(P) binding site [chemical binding]; other site 1127134008198 active site 1127134008199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127134008200 Helix-turn-helix domains; Region: HTH; cl00088 1127134008201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134008202 Transmembrane secretion effector; Region: MFS_3; pfam05977 1127134008203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134008204 putative substrate translocation pore; other site 1127134008205 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 1127134008206 META domain; Region: META; cl01245 1127134008207 META domain; Region: META; cl01245 1127134008208 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1127134008209 substrate binding site [chemical binding]; other site 1127134008210 dimer interface [polypeptide binding]; other site 1127134008211 catalytic triad [active] 1127134008212 Phosphoglycerate kinase; Region: PGK; pfam00162 1127134008213 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1127134008214 substrate binding site [chemical binding]; other site 1127134008215 hinge regions; other site 1127134008216 ADP binding site [chemical binding]; other site 1127134008217 catalytic site [active] 1127134008218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008219 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1127134008220 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1127134008221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1127134008222 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1127134008223 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1127134008224 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1127134008225 phosphate binding site [ion binding]; other site 1127134008226 putative substrate binding pocket [chemical binding]; other site 1127134008227 dimer interface [polypeptide binding]; other site 1127134008228 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1127134008229 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1127134008230 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1127134008231 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1127134008232 GIY-YIG motif/motif A; other site 1127134008233 active site 1127134008234 catalytic site [active] 1127134008235 putative DNA binding site [nucleotide binding]; other site 1127134008236 metal binding site [ion binding]; metal-binding site 1127134008237 UvrB/uvrC motif; Region: UVR; pfam02151 1127134008238 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1127134008239 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1127134008240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008241 NAD(P) binding site [chemical binding]; other site 1127134008242 active site 1127134008243 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1127134008244 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1127134008245 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1127134008246 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1127134008247 homopentamer interface [polypeptide binding]; other site 1127134008248 active site 1127134008249 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1127134008250 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 1127134008251 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1127134008252 dimerization interface [polypeptide binding]; other site 1127134008253 active site 1127134008254 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1127134008255 Lumazine binding domain; Region: Lum_binding; pfam00677 1127134008256 Lumazine binding domain; Region: Lum_binding; pfam00677 1127134008257 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1127134008258 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1127134008259 substrate binding site [chemical binding]; other site 1127134008260 hexamer interface [polypeptide binding]; other site 1127134008261 metal binding site [ion binding]; metal-binding site 1127134008262 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1127134008263 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1127134008264 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134008265 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1127134008266 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134008267 DNA binding residues [nucleotide binding] 1127134008268 Protein of unknown function (DUF419); Region: DUF419; cl15265 1127134008269 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1127134008270 putative RNA binding site [nucleotide binding]; other site 1127134008271 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1127134008272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134008273 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1127134008274 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1127134008275 putative active site [active] 1127134008276 substrate binding site [chemical binding]; other site 1127134008277 putative cosubstrate binding site; other site 1127134008278 catalytic site [active] 1127134008279 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1127134008280 substrate binding site [chemical binding]; other site 1127134008281 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1127134008282 active site 1127134008283 catalytic residues [active] 1127134008284 metal binding site [ion binding]; metal-binding site 1127134008285 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134008286 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134008287 Helix-turn-helix domains; Region: HTH; cl00088 1127134008288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134008289 Helix-turn-helix domains; Region: HTH; cl00088 1127134008290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008291 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1127134008292 NAD(P) binding site [chemical binding]; other site 1127134008293 active site 1127134008294 primosome assembly protein PriA; Provisional; Region: PRK14873 1127134008295 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1127134008296 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1127134008297 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1127134008298 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1127134008299 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1127134008300 Flavoprotein; Region: Flavoprotein; cl08021 1127134008301 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 1127134008302 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 1127134008303 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1127134008304 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1127134008305 catalytic site [active] 1127134008306 G-X2-G-X-G-K; other site 1127134008307 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 1127134008308 active site 1127134008309 dimer interface [polypeptide binding]; other site 1127134008310 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1127134008311 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127134008312 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134008313 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1127134008314 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127134008315 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134008316 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1127134008317 IMP binding site; other site 1127134008318 dimer interface [polypeptide binding]; other site 1127134008319 interdomain contacts; other site 1127134008320 partial ornithine binding site; other site 1127134008321 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1127134008322 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1127134008323 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1127134008324 catalytic site [active] 1127134008325 subunit interface [polypeptide binding]; other site 1127134008326 dihydroorotase; Validated; Region: pyrC; PRK09357 1127134008327 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127134008328 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1127134008329 active site 1127134008330 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1127134008331 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1127134008332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008333 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1127134008334 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1127134008335 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1127134008336 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1127134008337 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1127134008338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134008339 Helix-turn-helix domains; Region: HTH; cl00088 1127134008340 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1127134008341 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1127134008342 NAD(P) binding site [chemical binding]; other site 1127134008343 GXWXG protein; Region: GXWXG; pfam14231 1127134008344 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1127134008345 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 1127134008346 reactive center loop; other site 1127134008347 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1127134008348 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134008349 DNA binding residues [nucleotide binding] 1127134008350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134008351 YCII-related domain; Region: YCII; cl00999 1127134008352 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1127134008353 putative RNA binding site [nucleotide binding]; other site 1127134008354 elongation factor P; Validated; Region: PRK00529 1127134008355 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1127134008356 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1127134008357 RNA binding site [nucleotide binding]; other site 1127134008358 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1127134008359 RNA binding site [nucleotide binding]; other site 1127134008360 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1127134008361 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1127134008362 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1127134008363 active site 1127134008364 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127134008365 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127134008366 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1127134008367 Helix-turn-helix domains; Region: HTH; cl00088 1127134008368 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 1127134008369 Tetramer interface [polypeptide binding]; other site 1127134008370 active site 1127134008371 FMN-binding site [chemical binding]; other site 1127134008372 shikimate kinase; Reviewed; Region: aroK; PRK00131 1127134008373 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1127134008374 ADP binding site [chemical binding]; other site 1127134008375 magnesium binding site [ion binding]; other site 1127134008376 putative shikimate binding site; other site 1127134008377 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1127134008378 active site 1127134008379 dimer interface [polypeptide binding]; other site 1127134008380 metal binding site [ion binding]; metal-binding site 1127134008381 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1127134008382 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1127134008383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134008384 catalytic residue [active] 1127134008385 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1127134008386 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1127134008387 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1127134008388 shikimate binding site; other site 1127134008389 NAD(P) binding site [chemical binding]; other site 1127134008390 YceG-like family; Region: YceG; pfam02618 1127134008391 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 1127134008392 dimerization interface [polypeptide binding]; other site 1127134008393 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1127134008394 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1127134008395 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 1127134008396 motif 1; other site 1127134008397 active site 1127134008398 motif 2; other site 1127134008399 motif 3; other site 1127134008400 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1127134008401 DHHA1 domain; Region: DHHA1; pfam02272 1127134008402 recombination factor protein RarA; Reviewed; Region: PRK13342 1127134008403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134008404 Walker A motif; other site 1127134008405 ATP binding site [chemical binding]; other site 1127134008406 Walker B motif; other site 1127134008407 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1127134008408 PhoD-like phosphatase; Region: PhoD; pfam09423 1127134008409 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1127134008410 putative active site [active] 1127134008411 putative metal binding site [ion binding]; other site 1127134008412 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1127134008413 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134008414 substrate binding site [chemical binding]; other site 1127134008415 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1127134008416 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1127134008417 dimer interface [polypeptide binding]; other site 1127134008418 anticodon binding site; other site 1127134008419 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 1127134008420 homodimer interface [polypeptide binding]; other site 1127134008421 motif 1; other site 1127134008422 active site 1127134008423 motif 2; other site 1127134008424 GAD domain; Region: GAD; pfam02938 1127134008425 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1127134008426 active site 1127134008427 motif 3; other site 1127134008428 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 1127134008429 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1127134008430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008431 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1127134008432 NAD(P) binding site [chemical binding]; other site 1127134008433 active site 1127134008434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127134008435 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1127134008436 FeS/SAM binding site; other site 1127134008437 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1127134008438 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1127134008439 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1127134008440 dimer interface [polypeptide binding]; other site 1127134008441 PYR/PP interface [polypeptide binding]; other site 1127134008442 TPP binding site [chemical binding]; other site 1127134008443 substrate binding site [chemical binding]; other site 1127134008444 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1127134008445 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1127134008446 TPP-binding site [chemical binding]; other site 1127134008447 malate dehydrogenase; Provisional; Region: PRK05442 1127134008448 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1127134008449 NAD(P) binding site [chemical binding]; other site 1127134008450 dimer interface [polypeptide binding]; other site 1127134008451 malate binding site [chemical binding]; other site 1127134008452 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1127134008453 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1127134008454 dimer interface [polypeptide binding]; other site 1127134008455 motif 1; other site 1127134008456 active site 1127134008457 motif 2; other site 1127134008458 motif 3; other site 1127134008459 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1127134008460 anticodon binding site; other site 1127134008461 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1127134008462 active site 1127134008463 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1127134008464 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134008465 Walker A motif; other site 1127134008466 ATP binding site [chemical binding]; other site 1127134008467 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1127134008468 Peptidase family M23; Region: Peptidase_M23; pfam01551 1127134008469 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1127134008470 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1127134008471 catalytic residue [active] 1127134008472 NlpC/P60 family; Region: NLPC_P60; cl11438 1127134008473 AAA-like domain; Region: AAA_10; pfam12846 1127134008474 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1127134008475 Cutinase; Region: Cutinase; pfam01083 1127134008476 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1127134008477 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1127134008478 Zn2+ binding site [ion binding]; other site 1127134008479 Mg2+ binding site [ion binding]; other site 1127134008480 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1127134008481 synthetase active site [active] 1127134008482 NTP binding site [chemical binding]; other site 1127134008483 metal binding site [ion binding]; metal-binding site 1127134008484 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1127134008485 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1127134008486 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1127134008487 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 1127134008488 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134008489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1127134008490 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1127134008491 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1127134008492 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1127134008493 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1127134008494 Protein export membrane protein; Region: SecD_SecF; cl14618 1127134008495 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1127134008496 protein-export membrane protein SecD; Region: secD; TIGR01129 1127134008497 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1127134008498 Protein export membrane protein; Region: SecD_SecF; cl14618 1127134008499 Preprotein translocase subunit; Region: YajC; cl00806 1127134008500 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134008501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134008502 Helix-turn-helix domains; Region: HTH; cl00088 1127134008503 DivIVA domain; Region: DivI1A_domain; TIGR03544 1127134008504 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 1127134008505 DivIVA domain; Region: DivI1A_domain; TIGR03544 1127134008506 DivIVA domain; Region: DivI1A_domain; TIGR03544 1127134008507 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1127134008508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134008509 Walker A motif; other site 1127134008510 ATP binding site [chemical binding]; other site 1127134008511 Walker B motif; other site 1127134008512 arginine finger; other site 1127134008513 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1127134008514 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1127134008515 RuvA N terminal domain; Region: RuvA_N; pfam01330 1127134008516 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1127134008517 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 1127134008518 active site 1127134008519 putative DNA-binding cleft [nucleotide binding]; other site 1127134008520 dimer interface [polypeptide binding]; other site 1127134008521 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1127134008522 metal ion-dependent adhesion site (MIDAS); other site 1127134008523 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1127134008524 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1127134008525 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1127134008526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008527 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1127134008528 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 1127134008529 putative ADP-ribose binding site [chemical binding]; other site 1127134008530 putative active site [active] 1127134008531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134008532 dimerization interface [polypeptide binding]; other site 1127134008533 putative DNA binding site [nucleotide binding]; other site 1127134008534 putative Zn2+ binding site [ion binding]; other site 1127134008535 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1127134008536 putative hydrophobic ligand binding site [chemical binding]; other site 1127134008537 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1127134008538 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1127134008539 NAD binding site [chemical binding]; other site 1127134008540 substrate binding site [chemical binding]; other site 1127134008541 putative active site [active] 1127134008542 Helix-turn-helix domains; Region: HTH; cl00088 1127134008543 Transcriptional regulator; Region: Transcrip_reg; cl00361 1127134008544 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1127134008545 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 1127134008546 predicted active site [active] 1127134008547 catalytic triad [active] 1127134008548 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1127134008549 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1127134008550 active site 1127134008551 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1127134008552 catalytic triad [active] 1127134008553 dimer interface [polypeptide binding]; other site 1127134008554 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1127134008555 active site 1127134008556 multimer interface [polypeptide binding]; other site 1127134008557 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1127134008558 nudix motif; other site 1127134008559 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1127134008560 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1127134008561 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1127134008562 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134008563 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1127134008564 putative acyl-acceptor binding pocket; other site 1127134008565 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1127134008566 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1127134008567 nucleotide binding site/active site [active] 1127134008568 HIT family signature motif; other site 1127134008569 catalytic residue [active] 1127134008570 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1127134008571 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1127134008572 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1127134008573 active site 1127134008574 dimer interface [polypeptide binding]; other site 1127134008575 motif 1; other site 1127134008576 motif 2; other site 1127134008577 motif 3; other site 1127134008578 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1127134008579 anticodon binding site; other site 1127134008580 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1127134008581 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1127134008582 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 1127134008583 Sulfate transporter family; Region: Sulfate_transp; cl15842 1127134008584 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1127134008585 active site clefts [active] 1127134008586 zinc binding site [ion binding]; other site 1127134008587 dimer interface [polypeptide binding]; other site 1127134008588 Helix-turn-helix domains; Region: HTH; cl00088 1127134008589 Secretory lipase; Region: LIP; pfam03583 1127134008590 acyl-CoA synthetase; Validated; Region: PRK07788 1127134008591 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134008592 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134008593 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 1127134008594 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127134008595 Helix-turn-helix domains; Region: HTH; cl00088 1127134008596 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1127134008597 putative substrate binding pocket [chemical binding]; other site 1127134008598 putative dimerization interface [polypeptide binding]; other site 1127134008599 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134008600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1127134008601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127134008602 Coenzyme A binding pocket [chemical binding]; other site 1127134008603 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1127134008604 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1127134008605 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1127134008606 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1127134008607 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134008608 Walker A motif; other site 1127134008609 ATP binding site [chemical binding]; other site 1127134008610 Walker B motif; other site 1127134008611 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134008612 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1127134008613 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134008614 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1127134008615 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 1127134008616 SelR domain; Region: SelR; pfam01641 1127134008617 Chlorite dismutase; Region: Chlor_dismutase; cl01280 1127134008618 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134008619 dimerization interface [polypeptide binding]; other site 1127134008620 putative DNA binding site [nucleotide binding]; other site 1127134008621 putative Zn2+ binding site [ion binding]; other site 1127134008622 Cation efflux family; Region: Cation_efflux; cl00316 1127134008623 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1127134008624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008625 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1127134008626 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1127134008627 heme-binding site [chemical binding]; other site 1127134008628 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1127134008629 FAD binding pocket [chemical binding]; other site 1127134008630 FAD binding motif [chemical binding]; other site 1127134008631 phosphate binding motif [ion binding]; other site 1127134008632 beta-alpha-beta structure motif; other site 1127134008633 NAD binding pocket [chemical binding]; other site 1127134008634 Heme binding pocket [chemical binding]; other site 1127134008635 Helix-turn-helix domains; Region: HTH; cl00088 1127134008636 Rrf2 family protein; Region: rrf2_super; TIGR00738 1127134008637 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1127134008638 substrate binding site [chemical binding]; other site 1127134008639 active site 1127134008640 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1127134008641 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1127134008642 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1127134008643 catalytic site [active] 1127134008644 putative active site [active] 1127134008645 putative substrate binding site [chemical binding]; other site 1127134008646 HRDC domain; Region: HRDC; cl02578 1127134008647 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134008648 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1127134008649 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1127134008650 TPP-binding site; other site 1127134008651 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1127134008652 PYR/PP interface [polypeptide binding]; other site 1127134008653 dimer interface [polypeptide binding]; other site 1127134008654 TPP binding site [chemical binding]; other site 1127134008655 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1127134008656 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1127134008657 TRAM domain; Region: TRAM; cl01282 1127134008658 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1127134008659 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1127134008660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134008661 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1127134008662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008663 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1127134008664 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1127134008665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008666 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1127134008667 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1127134008668 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134008669 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134008670 DNA binding residues [nucleotide binding] 1127134008671 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1127134008672 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134008673 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1127134008674 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1127134008675 trimer interface [polypeptide binding]; other site 1127134008676 active site 1127134008677 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1127134008678 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1127134008679 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1127134008680 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1127134008681 active site 1127134008682 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1127134008683 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1127134008684 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1127134008685 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1127134008686 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134008687 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1127134008688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134008689 DNA binding residues [nucleotide binding] 1127134008690 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1127134008691 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1127134008692 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 1127134008693 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1127134008694 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1127134008695 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1127134008696 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1127134008697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127134008698 Histidine kinase; Region: HisKA_3; pfam07730 1127134008699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1127134008700 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134008701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134008702 active site 1127134008703 phosphorylation site [posttranslational modification] 1127134008704 intermolecular recognition site; other site 1127134008705 dimerization interface [polypeptide binding]; other site 1127134008706 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134008707 dimerization interface [polypeptide binding]; other site 1127134008708 DNA binding residues [nucleotide binding] 1127134008709 Protein of unknown function (DUF952); Region: DUF952; cl01393 1127134008710 Helix-turn-helix domains; Region: HTH; cl00088 1127134008711 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1127134008712 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1127134008713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134008714 ATP binding site [chemical binding]; other site 1127134008715 putative Mg++ binding site [ion binding]; other site 1127134008716 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134008717 nucleotide binding region [chemical binding]; other site 1127134008718 ATP-binding site [chemical binding]; other site 1127134008719 SWIM zinc finger; Region: SWIM; cl15408 1127134008720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134008721 S-adenosylmethionine binding site [chemical binding]; other site 1127134008722 Cupin domain; Region: Cupin_2; cl09118 1127134008723 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127134008724 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134008725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008726 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1127134008727 NAD(P) binding site [chemical binding]; other site 1127134008728 active site 1127134008729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134008730 Helix-turn-helix domains; Region: HTH; cl00088 1127134008731 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1127134008732 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134008733 ATP binding site [chemical binding]; other site 1127134008734 putative Mg++ binding site [ion binding]; other site 1127134008735 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1127134008736 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1127134008737 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1127134008738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134008739 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1127134008740 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1127134008741 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134008742 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1127134008743 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134008744 DNA binding residues [nucleotide binding] 1127134008745 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1127134008746 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134008747 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1127134008748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008749 CoA-ligase; Region: Ligase_CoA; cl02894 1127134008750 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134008751 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1127134008752 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 1127134008753 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1127134008754 Helix-turn-helix domains; Region: HTH; cl00088 1127134008755 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1127134008756 FeoA domain; Region: FeoA; cl00838 1127134008757 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1127134008758 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1127134008759 NAD binding site [chemical binding]; other site 1127134008760 homodimer interface [polypeptide binding]; other site 1127134008761 active site 1127134008762 substrate binding site [chemical binding]; other site 1127134008763 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1127134008764 PAC2 family; Region: PAC2; cl00847 1127134008765 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134008766 ATP binding site [chemical binding]; other site 1127134008767 putative Mg++ binding site [ion binding]; other site 1127134008768 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134008769 nucleotide binding region [chemical binding]; other site 1127134008770 ATP-binding site [chemical binding]; other site 1127134008771 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1127134008772 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1127134008773 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1127134008774 dimer interface [polypeptide binding]; other site 1127134008775 active site 1127134008776 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1127134008777 catalytic residues [active] 1127134008778 substrate binding site [chemical binding]; other site 1127134008779 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 1127134008780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134008781 S-adenosylmethionine binding site [chemical binding]; other site 1127134008782 Helix-turn-helix domains; Region: HTH; cl00088 1127134008783 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1127134008784 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1127134008785 dimerization interface [polypeptide binding]; other site 1127134008786 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1127134008787 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1127134008788 dimer interface [polypeptide binding]; other site 1127134008789 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1127134008790 catalytic triad [active] 1127134008791 peroxidatic and resolving cysteines [active] 1127134008792 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1127134008793 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1127134008794 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1127134008795 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127134008796 putative aminotransferase; Validated; Region: PRK07480 1127134008797 inhibitor-cofactor binding pocket; inhibition site 1127134008798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134008799 catalytic residue [active] 1127134008800 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1127134008801 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134008802 ATP binding site [chemical binding]; other site 1127134008803 putative Mg++ binding site [ion binding]; other site 1127134008804 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134008805 nucleotide binding region [chemical binding]; other site 1127134008806 ATP-binding site [chemical binding]; other site 1127134008807 Helicase associated domain (HA2); Region: HA2; cl04503 1127134008808 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1127134008809 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1127134008810 ATP cone domain; Region: ATP-cone; pfam03477 1127134008811 LexA repressor; Validated; Region: PRK00215 1127134008812 Helix-turn-helix domains; Region: HTH; cl00088 1127134008813 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1127134008814 Catalytic site [active] 1127134008815 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1127134008816 Helix-turn-helix domains; Region: HTH; cl00088 1127134008817 short chain dehydrogenase; Provisional; Region: PRK07814 1127134008818 classical (c) SDRs; Region: SDR_c; cd05233 1127134008819 NAD(P) binding site [chemical binding]; other site 1127134008820 active site 1127134008821 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1127134008822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008823 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134008824 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134008825 active site 1127134008826 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1127134008827 putative acyl-acceptor binding pocket; other site 1127134008828 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1127134008829 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1127134008830 HflX GTPase family; Region: HflX; cd01878 1127134008831 G1 box; other site 1127134008832 GTP/Mg2+ binding site [chemical binding]; other site 1127134008833 Switch I region; other site 1127134008834 G2 box; other site 1127134008835 G3 box; other site 1127134008836 Switch II region; other site 1127134008837 G4 box; other site 1127134008838 G5 box; other site 1127134008839 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1127134008840 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1127134008841 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1127134008842 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1127134008843 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1127134008844 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134008845 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1127134008846 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 1127134008847 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1127134008848 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1127134008849 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1127134008850 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1127134008851 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1127134008852 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127134008853 FeS/SAM binding site; other site 1127134008854 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1127134008855 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1127134008856 Walker A/P-loop; other site 1127134008857 ATP binding site [chemical binding]; other site 1127134008858 Q-loop/lid; other site 1127134008859 ABC transporter signature motif; other site 1127134008860 Walker B; other site 1127134008861 D-loop; other site 1127134008862 H-loop/switch region; other site 1127134008863 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1127134008864 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1127134008865 substrate binding pocket [chemical binding]; other site 1127134008866 membrane-bound complex binding site; other site 1127134008867 hinge residues; other site 1127134008868 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1127134008869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134008870 dimer interface [polypeptide binding]; other site 1127134008871 conserved gate region; other site 1127134008872 putative PBP binding loops; other site 1127134008873 ABC-ATPase subunit interface; other site 1127134008874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134008875 dimer interface [polypeptide binding]; other site 1127134008876 conserved gate region; other site 1127134008877 putative PBP binding loops; other site 1127134008878 ABC-ATPase subunit interface; other site 1127134008879 RecX family; Region: RecX; cl00936 1127134008880 recombinase A; Provisional; Region: recA; PRK09354 1127134008881 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1127134008882 hexamer interface [polypeptide binding]; other site 1127134008883 Walker A motif; other site 1127134008884 ATP binding site [chemical binding]; other site 1127134008885 Walker B motif; other site 1127134008886 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1127134008887 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134008888 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134008889 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134008890 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134008891 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134008892 active site 1127134008893 metal binding site [ion binding]; metal-binding site 1127134008894 CGNR zinc finger; Region: zf-CGNR; pfam11706 1127134008895 Phosphotransferase enzyme family; Region: APH; pfam01636 1127134008896 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: APH; cd05150 1127134008897 active site 1127134008898 ATP binding site [chemical binding]; other site 1127134008899 antibiotic binding site [chemical binding]; other site 1127134008900 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1127134008901 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1127134008902 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1127134008903 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1127134008904 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134008905 Helix-turn-helix domains; Region: HTH; cl00088 1127134008906 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134008907 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134008908 active site 1127134008909 PspA/IM30 family; Region: PspA_IM30; pfam04012 1127134008910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134008911 Competence-damaged protein; Region: CinA; cl00666 1127134008912 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1127134008913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127134008914 Coenzyme A binding pocket [chemical binding]; other site 1127134008915 YCII-related domain; Region: YCII; cl00999 1127134008916 Integral membrane protein TerC family; Region: TerC; cl10468 1127134008917 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134008918 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 1127134008919 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1127134008920 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134008921 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1127134008922 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1127134008923 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1127134008924 dimer interface [polypeptide binding]; other site 1127134008925 active site 1127134008926 catalytic residue [active] 1127134008927 HicB family; Region: HicB; pfam05534 1127134008928 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1127134008929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127134008930 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134008931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1127134008932 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134008933 DNA binding residues [nucleotide binding] 1127134008934 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134008935 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1127134008936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008937 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1127134008938 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134008939 active site 1127134008940 metal binding site [ion binding]; metal-binding site 1127134008941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1127134008942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1127134008943 Helix-turn-helix domains; Region: HTH; cl00088 1127134008944 Helix-turn-helix domains; Region: HTH; cl00088 1127134008945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127134008946 TPR motif; other site 1127134008947 binding surface 1127134008948 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1127134008949 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1127134008950 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1127134008951 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1127134008952 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1127134008953 oligomer interface [polypeptide binding]; other site 1127134008954 RNA binding site [nucleotide binding]; other site 1127134008955 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1127134008956 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1127134008957 RNase E interface [polypeptide binding]; other site 1127134008958 trimer interface [polypeptide binding]; other site 1127134008959 active site 1127134008960 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1127134008961 putative nucleic acid binding region [nucleotide binding]; other site 1127134008962 G-X-X-G motif; other site 1127134008963 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1127134008964 RNA binding site [nucleotide binding]; other site 1127134008965 domain interface; other site 1127134008966 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1127134008967 16S/18S rRNA binding site [nucleotide binding]; other site 1127134008968 S13e-L30e interaction site [polypeptide binding]; other site 1127134008969 25S rRNA binding site [nucleotide binding]; other site 1127134008970 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1127134008971 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1127134008972 active site 1127134008973 Riboflavin kinase; Region: Flavokinase; cl03312 1127134008974 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1127134008975 Helix-turn-helix domains; Region: HTH; cl00088 1127134008976 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1127134008977 FeoA domain; Region: FeoA; cl00838 1127134008978 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1127134008979 tartrate dehydrogenase; Provisional; Region: PRK08194 1127134008980 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134008981 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1127134008982 tetramerization interface [polypeptide binding]; other site 1127134008983 NAD(P) binding site [chemical binding]; other site 1127134008984 catalytic residues [active] 1127134008985 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 1127134008986 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127134008987 inhibitor-cofactor binding pocket; inhibition site 1127134008988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134008989 catalytic residue [active] 1127134008990 Cyclophilin-like; Region: Cyclophil_like; cl00950 1127134008991 putative amidase; Provisional; Region: PRK06169 1127134008992 Amidase; Region: Amidase; cl11426 1127134008993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134008994 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1127134008995 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1127134008996 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1127134008997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134008998 DNA-binding site [nucleotide binding]; DNA binding site 1127134008999 FCD domain; Region: FCD; cl11656 1127134009000 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 1127134009001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134009002 Helix-turn-helix domains; Region: HTH; cl00088 1127134009003 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1127134009004 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1127134009005 RNA binding site [nucleotide binding]; other site 1127134009006 active site 1127134009007 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1127134009008 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1127134009009 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1127134009010 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1127134009011 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1127134009012 active site 1127134009013 metal binding site [ion binding]; metal-binding site 1127134009014 putative efflux protein, MATE family; Region: matE; TIGR00797 1127134009015 MatE; Region: MatE; cl10513 1127134009016 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1127134009017 DHH family; Region: DHH; pfam01368 1127134009018 DHHA1 domain; Region: DHHA1; pfam02272 1127134009019 Ribosome-binding factor A; Region: RBFA; cl00542 1127134009020 Protein of unknown function (DUF503); Region: DUF503; cl00669 1127134009021 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1127134009022 translation initiation factor IF-2; Region: IF-2; TIGR00487 1127134009023 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1127134009024 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1127134009025 G1 box; other site 1127134009026 putative GEF interaction site [polypeptide binding]; other site 1127134009027 GTP/Mg2+ binding site [chemical binding]; other site 1127134009028 Switch I region; other site 1127134009029 G2 box; other site 1127134009030 G3 box; other site 1127134009031 Switch II region; other site 1127134009032 G4 box; other site 1127134009033 G5 box; other site 1127134009034 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1127134009035 Translation-initiation factor 2; Region: IF-2; pfam11987 1127134009036 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1127134009037 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1127134009038 NusA N-terminal domain; Region: NusA_N; pfam08529 1127134009039 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1127134009040 RNA binding site [nucleotide binding]; other site 1127134009041 homodimer interface [polypeptide binding]; other site 1127134009042 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1127134009043 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1127134009044 G-X-X-G motif; other site 1127134009045 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1127134009046 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 1127134009047 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 1127134009048 Sm1 motif; other site 1127134009049 D1 - D2 interaction site; other site 1127134009050 D3 - B interaction site; other site 1127134009051 Hfq - Hfq interaction site; other site 1127134009052 RNA binding pocket [nucleotide binding]; other site 1127134009053 Sm2 motif; other site 1127134009054 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1127134009055 dinuclear metal binding motif [ion binding]; other site 1127134009056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134009057 NAD(P) binding site [chemical binding]; other site 1127134009058 active site 1127134009059 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1127134009060 active site 1127134009061 hypothetical protein; Validated; Region: PRK07121 1127134009062 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1127134009063 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 1127134009064 dimer interface [polypeptide binding]; other site 1127134009065 motif 1; other site 1127134009066 active site 1127134009067 motif 2; other site 1127134009068 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1127134009069 putative deacylase active site [active] 1127134009070 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1127134009071 active site 1127134009072 motif 3; other site 1127134009073 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1127134009074 anticodon binding site; other site 1127134009075 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 1127134009076 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1127134009077 substrate binding pocket [chemical binding]; other site 1127134009078 membrane-bound complex binding site; other site 1127134009079 hinge residues; other site 1127134009080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134009081 dimer interface [polypeptide binding]; other site 1127134009082 conserved gate region; other site 1127134009083 putative PBP binding loops; other site 1127134009084 ABC-ATPase subunit interface; other site 1127134009085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134009086 dimer interface [polypeptide binding]; other site 1127134009087 conserved gate region; other site 1127134009088 putative PBP binding loops; other site 1127134009089 ABC-ATPase subunit interface; other site 1127134009090 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 1127134009091 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1127134009092 Walker A/P-loop; other site 1127134009093 ATP binding site [chemical binding]; other site 1127134009094 Q-loop/lid; other site 1127134009095 ABC transporter signature motif; other site 1127134009096 Walker B; other site 1127134009097 D-loop; other site 1127134009098 H-loop/switch region; other site 1127134009099 Protein of unknown function (DUF328); Region: DUF328; cl01143 1127134009100 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134009101 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1127134009102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134009103 putative substrate translocation pore; other site 1127134009104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134009105 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1127134009106 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1127134009107 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134009108 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 1127134009109 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1127134009110 putative active site [active] 1127134009111 putative substrate binding site [chemical binding]; other site 1127134009112 ATP binding site [chemical binding]; other site 1127134009113 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1127134009114 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134009115 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1127134009116 catalytic triad [active] 1127134009117 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1127134009118 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1127134009119 homodimer interface [polypeptide binding]; other site 1127134009120 Walker A motif; other site 1127134009121 ATP binding site [chemical binding]; other site 1127134009122 hydroxycobalamin binding site [chemical binding]; other site 1127134009123 Walker B motif; other site 1127134009124 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1127134009125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134009126 Walker A motif; other site 1127134009127 ATP binding site [chemical binding]; other site 1127134009128 Walker B motif; other site 1127134009129 arginine finger; other site 1127134009130 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1127134009131 metal ion-dependent adhesion site (MIDAS); other site 1127134009132 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134009133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134009134 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1127134009135 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1127134009136 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134009137 cobyric acid synthase; Provisional; Region: PRK00784 1127134009138 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134009139 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134009140 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1127134009141 catalytic triad [active] 1127134009142 methionine aminopeptidase; Provisional; Region: PRK12318 1127134009143 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1127134009144 active site 1127134009145 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1127134009146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134009147 DNA-binding site [nucleotide binding]; DNA binding site 1127134009148 UTRA domain; Region: UTRA; cl01230 1127134009149 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1127134009150 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 1127134009151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134009152 motif II; other site 1127134009153 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1127134009154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134009155 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1127134009156 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134009157 Walker A/P-loop; other site 1127134009158 ATP binding site [chemical binding]; other site 1127134009159 Q-loop/lid; other site 1127134009160 ABC transporter signature motif; other site 1127134009161 Walker B; other site 1127134009162 D-loop; other site 1127134009163 H-loop/switch region; other site 1127134009164 TOBE domain; Region: TOBE_2; cl01440 1127134009165 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1127134009166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134009167 dimer interface [polypeptide binding]; other site 1127134009168 conserved gate region; other site 1127134009169 putative PBP binding loops; other site 1127134009170 ABC-ATPase subunit interface; other site 1127134009171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134009172 dimer interface [polypeptide binding]; other site 1127134009173 conserved gate region; other site 1127134009174 putative PBP binding loops; other site 1127134009175 ABC-ATPase subunit interface; other site 1127134009176 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1127134009177 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134009178 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134009179 active site 1127134009180 TIGR03085 family protein; Region: TIGR03085 1127134009181 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1127134009182 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134009183 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134009184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134009185 non-specific DNA binding site [nucleotide binding]; other site 1127134009186 salt bridge; other site 1127134009187 sequence-specific DNA binding site [nucleotide binding]; other site 1127134009188 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134009189 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134009190 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1127134009191 classical (c) SDRs; Region: SDR_c; cd05233 1127134009192 NAD(P) binding site [chemical binding]; other site 1127134009193 active site 1127134009194 Helix-turn-helix domains; Region: HTH; cl00088 1127134009195 TIGR03118 family protein; Region: PEPCTERM_chp_1 1127134009196 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1127134009197 heme-binding site [chemical binding]; other site 1127134009198 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1127134009199 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1127134009200 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134009201 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1127134009202 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1127134009203 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1127134009204 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1127134009205 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1127134009206 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1127134009207 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1127134009208 active site 1127134009209 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1127134009210 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1127134009211 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1127134009212 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1127134009213 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1127134009214 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1127134009215 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1127134009216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127134009217 FeS/SAM binding site; other site 1127134009218 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1127134009219 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 1127134009220 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1127134009221 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 1127134009222 hinge region; other site 1127134009223 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1127134009224 putative nucleotide binding site [chemical binding]; other site 1127134009225 uridine monophosphate binding site [chemical binding]; other site 1127134009226 homohexameric interface [polypeptide binding]; other site 1127134009227 elongation factor Ts; Provisional; Region: tsf; PRK09377 1127134009228 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 1127134009229 Elongation factor TS; Region: EF_TS; pfam00889 1127134009230 Elongation factor TS; Region: EF_TS; pfam00889 1127134009231 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1127134009232 rRNA interaction site [nucleotide binding]; other site 1127134009233 S8 interaction site; other site 1127134009234 putative laminin-1 binding site; other site 1127134009235 Peptidase family M23; Region: Peptidase_M23; pfam01551 1127134009236 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 1127134009237 Domain of unknown function (DUF202); Region: DUF202; cl09954 1127134009238 Domain of unknown function (DUF202); Region: DUF202; cl09954 1127134009239 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1127134009240 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1127134009241 active site 1127134009242 DNA binding site [nucleotide binding] 1127134009243 Int/Topo IB signature motif; other site 1127134009244 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1127134009245 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1127134009246 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1127134009247 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1127134009248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134009249 Walker A motif; other site 1127134009250 ATP binding site [chemical binding]; other site 1127134009251 Walker B motif; other site 1127134009252 arginine finger; other site 1127134009253 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1127134009254 Restriction endonuclease; Region: Mrr_cat; cl00516 1127134009255 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1127134009256 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1127134009257 RNA/DNA hybrid binding site [nucleotide binding]; other site 1127134009258 active site 1127134009259 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1127134009260 Catalytic site [active] 1127134009261 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1127134009262 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1127134009263 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 1127134009264 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1127134009265 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1127134009266 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1127134009267 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1127134009268 RNA binding site [nucleotide binding]; other site 1127134009269 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1127134009270 active site 1127134009271 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134009272 metal binding site [ion binding]; metal-binding site 1127134009273 response regulator; Provisional; Region: PRK09483 1127134009274 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134009275 DNA binding residues [nucleotide binding] 1127134009276 dimerization interface [polypeptide binding]; other site 1127134009277 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1127134009278 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134009279 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134009280 AMP-binding domain protein; Validated; Region: PRK08315 1127134009281 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134009282 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134009283 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1127134009284 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1127134009285 RimM N-terminal domain; Region: RimM; pfam01782 1127134009286 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1127134009287 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1127134009288 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 1127134009289 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1127134009290 putative active site [active] 1127134009291 signal recognition particle protein; Provisional; Region: PRK10867 1127134009292 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1127134009293 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1127134009294 P loop; other site 1127134009295 GTP binding site [chemical binding]; other site 1127134009296 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1127134009297 PII uridylyl-transferase; Provisional; Region: PRK03381 1127134009298 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1127134009299 metal binding triad [ion binding]; metal-binding site 1127134009300 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1127134009301 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 1127134009302 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1127134009303 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1127134009304 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1127134009305 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1127134009306 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1127134009307 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1127134009308 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134009309 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 1127134009310 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 1127134009311 Phage shock protein B; Region: PspB; cl05946 1127134009312 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1127134009313 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1127134009314 Walker A/P-loop; other site 1127134009315 ATP binding site [chemical binding]; other site 1127134009316 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1127134009317 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1127134009318 ABC transporter signature motif; other site 1127134009319 Walker B; other site 1127134009320 D-loop; other site 1127134009321 H-loop/switch region; other site 1127134009322 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1127134009323 2TM domain; Region: 2TM; pfam13239 1127134009324 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1127134009325 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503 1127134009326 Acylphosphatase; Region: Acylphosphatase; cl00551 1127134009327 OsmC-like protein; Region: OsmC; cl00767 1127134009328 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1127134009329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134009330 active site 1127134009331 phosphorylation site [posttranslational modification] 1127134009332 intermolecular recognition site; other site 1127134009333 dimerization interface [polypeptide binding]; other site 1127134009334 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127134009335 DNA binding site [nucleotide binding] 1127134009336 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1127134009337 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1127134009338 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1127134009339 Ligand Binding Site [chemical binding]; other site 1127134009340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127134009341 dimer interface [polypeptide binding]; other site 1127134009342 phosphorylation site [posttranslational modification] 1127134009343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134009344 ATP binding site [chemical binding]; other site 1127134009345 Mg2+ binding site [ion binding]; other site 1127134009346 G-X-G motif; other site 1127134009347 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 1127134009348 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1127134009349 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1127134009350 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1127134009351 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1127134009352 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1127134009353 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1127134009354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134009355 hypothetical protein; Provisional; Region: PRK07945 1127134009356 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1127134009357 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134009358 folate binding site [chemical binding]; other site 1127134009359 NADP+ binding site [chemical binding]; other site 1127134009360 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1127134009361 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1127134009362 DNA binding site [nucleotide binding] 1127134009363 catalytic residue [active] 1127134009364 H2TH interface [polypeptide binding]; other site 1127134009365 putative catalytic residues [active] 1127134009366 turnover-facilitating residue; other site 1127134009367 intercalation triad [nucleotide binding]; other site 1127134009368 8OG recognition residue [nucleotide binding]; other site 1127134009369 putative reading head residues; other site 1127134009370 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1127134009371 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1127134009372 ribonuclease III; Reviewed; Region: rnc; PRK00102 1127134009373 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1127134009374 dimerization interface [polypeptide binding]; other site 1127134009375 active site 1127134009376 metal binding site [ion binding]; metal-binding site 1127134009377 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1127134009378 dsRNA binding site [nucleotide binding]; other site 1127134009379 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1127134009380 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1127134009381 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1127134009382 GtrA-like protein; Region: GtrA; cl00971 1127134009383 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1127134009384 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1127134009385 active site 1127134009386 (T/H)XGH motif; other site 1127134009387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134009388 S-adenosylmethionine binding site [chemical binding]; other site 1127134009389 pyruvate carboxylase; Reviewed; Region: PRK12999 1127134009390 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127134009391 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134009392 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1127134009393 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1127134009394 active site 1127134009395 catalytic residues [active] 1127134009396 metal binding site [ion binding]; metal-binding site 1127134009397 homodimer binding site [polypeptide binding]; other site 1127134009398 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1127134009399 carboxyltransferase (CT) interaction site; other site 1127134009400 biotinylation site [posttranslational modification]; other site 1127134009401 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1127134009402 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1127134009403 active site 1127134009404 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1127134009405 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1127134009406 THF binding site; other site 1127134009407 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1127134009408 substrate binding site [chemical binding]; other site 1127134009409 THF binding site; other site 1127134009410 zinc-binding site [ion binding]; other site 1127134009411 citrate synthase; Provisional; Region: PRK14033 1127134009412 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1127134009413 oxalacetate binding site [chemical binding]; other site 1127134009414 citrylCoA binding site [chemical binding]; other site 1127134009415 coenzyme A binding site [chemical binding]; other site 1127134009416 catalytic triad [active] 1127134009417 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 1127134009418 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1127134009419 tetramer interface [polypeptide binding]; other site 1127134009420 active site 1127134009421 Mg2+/Mn2+ binding site [ion binding]; other site 1127134009422 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1127134009423 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127134009424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134009425 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1127134009426 Domain of unknown function (DUF955); Region: DUF955; cl01076 1127134009427 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1127134009428 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1127134009429 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1127134009430 generic binding surface II; other site 1127134009431 ssDNA binding site; other site 1127134009432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134009433 ATP binding site [chemical binding]; other site 1127134009434 putative Mg++ binding site [ion binding]; other site 1127134009435 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134009436 nucleotide binding region [chemical binding]; other site 1127134009437 ATP-binding site [chemical binding]; other site 1127134009438 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1127134009439 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1127134009440 DAK2 domain; Region: Dak2; cl03685 1127134009441 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1127134009442 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 1127134009443 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1127134009444 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1127134009445 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134009446 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134009447 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1127134009448 ligand binding site [chemical binding]; other site 1127134009449 active site 1127134009450 UGI interface [polypeptide binding]; other site 1127134009451 catalytic site [active] 1127134009452 thiamine monophosphate kinase; Provisional; Region: PRK05731 1127134009453 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1127134009454 ATP binding site [chemical binding]; other site 1127134009455 dimerization interface [polypeptide binding]; other site 1127134009456 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1127134009457 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1127134009458 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1127134009459 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134009460 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1127134009461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134009462 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1127134009463 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1127134009464 polyphosphate kinase; Provisional; Region: PRK05443 1127134009465 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1127134009466 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1127134009467 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1127134009468 putative domain interface [polypeptide binding]; other site 1127134009469 putative active site [active] 1127134009470 catalytic site [active] 1127134009471 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1127134009472 putative domain interface [polypeptide binding]; other site 1127134009473 putative active site [active] 1127134009474 catalytic site [active] 1127134009475 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1127134009476 active site 1127134009477 Ap6A binding site [chemical binding]; other site 1127134009478 nudix motif; other site 1127134009479 metal binding site [ion binding]; metal-binding site 1127134009480 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127134009481 catalytic core [active] 1127134009482 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1127134009483 IHF - DNA interface [nucleotide binding]; other site 1127134009484 IHF dimer interface [polypeptide binding]; other site 1127134009485 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1127134009486 substrate binding site [chemical binding]; other site 1127134009487 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1127134009488 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1127134009489 substrate binding site [chemical binding]; other site 1127134009490 ligand binding site [chemical binding]; other site 1127134009491 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1127134009492 Helix-turn-helix domains; Region: HTH; cl00088 1127134009493 Bacterial transcriptional regulator; Region: IclR; pfam01614 1127134009494 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134009495 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1127134009496 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1127134009497 HIGH motif; other site 1127134009498 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1127134009499 active site 1127134009500 KMSKS motif; other site 1127134009501 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1127134009502 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1127134009503 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1127134009504 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127134009505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134009506 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1127134009507 tartrate dehydrogenase; Provisional; Region: PRK08194 1127134009508 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1127134009509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134009510 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1127134009511 putative L-serine binding site [chemical binding]; other site 1127134009512 Spore germination protein; Region: Spore_permease; cl15802 1127134009513 amino acid transporter; Region: 2A0306; TIGR00909 1127134009514 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1127134009515 Helix-turn-helix domains; Region: HTH; cl00088 1127134009516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134009517 Helix-turn-helix domains; Region: HTH; cl00088 1127134009518 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134009519 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1127134009520 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1127134009521 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1127134009522 NAD(P) binding site [chemical binding]; other site 1127134009523 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134009524 acyl-CoA synthetase; Provisional; Region: PRK13388 1127134009525 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134009526 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1127134009527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134009528 Helix-turn-helix domains; Region: HTH; cl00088 1127134009529 short chain dehydrogenase; Provisional; Region: PRK06197 1127134009530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134009531 NAD(P) binding site [chemical binding]; other site 1127134009532 active site 1127134009533 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1127134009534 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134009535 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134009536 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 1127134009537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134009538 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1127134009539 Walker A motif; other site 1127134009540 ATP binding site [chemical binding]; other site 1127134009541 Walker B motif; other site 1127134009542 arginine finger; other site 1127134009543 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1127134009544 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1127134009545 MoxR-like ATPases [General function prediction only]; Region: COG0714 1127134009546 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1127134009547 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1127134009548 conserved cys residue [active] 1127134009549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134009550 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134009551 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134009552 active site 1127134009553 metal binding site [ion binding]; metal-binding site 1127134009554 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 1127134009555 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1127134009556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134009557 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1127134009558 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1127134009559 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1127134009560 putative valine binding site [chemical binding]; other site 1127134009561 dimer interface [polypeptide binding]; other site 1127134009562 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1127134009563 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1127134009564 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1127134009565 PYR/PP interface [polypeptide binding]; other site 1127134009566 dimer interface [polypeptide binding]; other site 1127134009567 TPP binding site [chemical binding]; other site 1127134009568 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1127134009569 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1127134009570 TPP-binding site [chemical binding]; other site 1127134009571 dimer interface [polypeptide binding]; other site 1127134009572 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1127134009573 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1127134009574 Dehydratase family; Region: ILVD_EDD; cl00340 1127134009575 DoxX; Region: DoxX; cl00976 1127134009576 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1127134009577 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1127134009578 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1127134009579 GatB domain; Region: GatB_Yqey; cl11497 1127134009580 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1127134009581 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134009582 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134009583 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1127134009584 dimerization interface [polypeptide binding]; other site 1127134009585 allosteric effector site; other site 1127134009586 active site 1127134009587 ADP/pyrophosphate binding site [chemical binding]; other site 1127134009588 fructose-1,6-bisphosphate binding site; other site 1127134009589 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134009590 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134009591 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134009592 active site 1127134009593 ATP binding site [chemical binding]; other site 1127134009594 substrate binding site [chemical binding]; other site 1127134009595 activation loop (A-loop); other site 1127134009596 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134009597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134009598 active site 1127134009599 phosphorylation site [posttranslational modification] 1127134009600 intermolecular recognition site; other site 1127134009601 dimerization interface [polypeptide binding]; other site 1127134009602 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134009603 DNA binding residues [nucleotide binding] 1127134009604 dimerization interface [polypeptide binding]; other site 1127134009605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127134009606 Histidine kinase; Region: HisKA_3; pfam07730 1127134009607 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1127134009608 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1127134009609 Walker A/P-loop; other site 1127134009610 ATP binding site [chemical binding]; other site 1127134009611 Q-loop/lid; other site 1127134009612 ABC transporter signature motif; other site 1127134009613 Walker B; other site 1127134009614 D-loop; other site 1127134009615 H-loop/switch region; other site 1127134009616 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1127134009617 FtsX-like permease family; Region: FtsX; cl15850 1127134009618 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1127134009619 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1127134009620 FtsX-like permease family; Region: FtsX; cl15850 1127134009621 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134009622 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134009623 active site 1127134009624 ATP binding site [chemical binding]; other site 1127134009625 substrate binding site [chemical binding]; other site 1127134009626 activation loop (A-loop); other site 1127134009627 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134009628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134009629 active site 1127134009630 phosphorylation site [posttranslational modification] 1127134009631 intermolecular recognition site; other site 1127134009632 dimerization interface [polypeptide binding]; other site 1127134009633 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134009634 dimerization interface [polypeptide binding]; other site 1127134009635 DNA binding residues [nucleotide binding] 1127134009636 Histidine kinase; Region: HisKA_3; pfam07730 1127134009637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134009638 ATP binding site [chemical binding]; other site 1127134009639 Mg2+ binding site [ion binding]; other site 1127134009640 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 1127134009641 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1127134009642 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1127134009643 putative hydrophobic ligand binding site [chemical binding]; other site 1127134009644 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1127134009645 Amidase; Region: Amidase; cl11426 1127134009646 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 1127134009647 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1127134009648 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1127134009649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127134009650 Coenzyme A binding pocket [chemical binding]; other site 1127134009651 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134009652 AAA domain; Region: AAA_21; pfam13304 1127134009653 Walker A/P-loop; other site 1127134009654 ATP binding site [chemical binding]; other site 1127134009655 AAA domain; Region: AAA_21; pfam13304 1127134009656 hypothetical protein; Validated; Region: PRK07121 1127134009657 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1127134009658 molybdopterin cofactor binding site; other site 1127134009659 Helix-turn-helix domains; Region: HTH; cl00088 1127134009660 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1127134009661 active site 1127134009662 catalytic residues [active] 1127134009663 metal binding site [ion binding]; metal-binding site 1127134009664 H+ Antiporter protein; Region: 2A0121; TIGR00900 1127134009665 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1127134009666 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1127134009667 nucleotide binding pocket [chemical binding]; other site 1127134009668 K-X-D-G motif; other site 1127134009669 catalytic site [active] 1127134009670 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1127134009671 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1127134009672 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1127134009673 Dimer interface [polypeptide binding]; other site 1127134009674 BRCT sequence motif; other site 1127134009675 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1127134009676 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1127134009677 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1127134009678 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134009679 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1127134009680 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134009681 catalytic residue [active] 1127134009682 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1127134009683 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1127134009684 active site 1127134009685 DNA binding site [nucleotide binding] 1127134009686 Int/Topo IB signature motif; other site 1127134009687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1127134009688 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1127134009689 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134009690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134009691 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 1127134009692 nudix motif; other site 1127134009693 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134009694 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134009695 catalytic residue [active] 1127134009696 extended (e) SDRs; Region: SDR_e; cd08946 1127134009697 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1127134009698 NAD(P) binding site [chemical binding]; other site 1127134009699 active site 1127134009700 substrate binding site [chemical binding]; other site 1127134009701 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134009702 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134009703 Helix-turn-helix domains; Region: HTH; cl00088 1127134009704 Domain of unknown function (DUF305); Region: DUF305; cl15795 1127134009705 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1127134009706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134009707 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1127134009708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134009709 Helix-turn-helix domains; Region: HTH; cl00088 1127134009710 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1127134009711 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1127134009712 metal-binding site [ion binding] 1127134009713 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1127134009714 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1127134009715 active site residue [active] 1127134009716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134009717 H+ Antiporter protein; Region: 2A0121; TIGR00900 1127134009718 putative substrate translocation pore; other site 1127134009719 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1127134009720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134009721 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1127134009722 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1127134009723 dimer interface [polypeptide binding]; other site 1127134009724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134009725 catalytic residue [active] 1127134009726 L-ascorbate oxidase, plant type; Region: ascorbase; TIGR03388 1127134009727 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1127134009728 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1127134009729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134009730 Helix-turn-helix domains; Region: HTH; cl00088 1127134009731 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1127134009732 active site 1127134009733 FMN binding site [chemical binding]; other site 1127134009734 substrate binding site [chemical binding]; other site 1127134009735 putative catalytic residue [active] 1127134009736 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1127134009737 putative acyl-acceptor binding pocket; other site 1127134009738 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134009739 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1127134009740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134009741 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134009742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127134009743 Helix-turn-helix domains; Region: HTH; cl00088 1127134009744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1127134009745 dimerization interface [polypeptide binding]; other site 1127134009746 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134009747 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134009748 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134009749 active site 1127134009750 ATP binding site [chemical binding]; other site 1127134009751 substrate binding site [chemical binding]; other site 1127134009752 activation loop (A-loop); other site 1127134009753 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1127134009754 putative active site [active] 1127134009755 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1127134009756 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1127134009757 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1127134009758 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1127134009759 Ligand binding site [chemical binding]; other site 1127134009760 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1127134009761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134009762 S-adenosylmethionine binding site [chemical binding]; other site 1127134009763 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1127134009764 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1127134009765 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1127134009766 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1127134009767 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1127134009768 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1127134009769 Trp docking motif [polypeptide binding]; other site 1127134009770 active site 1127134009771 PQQ-like domain; Region: PQQ_2; pfam13360 1127134009772 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1127134009773 Trp docking motif [polypeptide binding]; other site 1127134009774 active site 1127134009775 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1127134009776 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1127134009777 trimer interface [polypeptide binding]; other site 1127134009778 active site 1127134009779 substrate binding site [chemical binding]; other site 1127134009780 CoA binding site [chemical binding]; other site 1127134009781 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 1127134009782 tocopherol O-methyltransferase; Region: PLN02244 1127134009783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134009784 S-adenosylmethionine binding site [chemical binding]; other site 1127134009785 enoyl-CoA hydratase; Provisional; Region: PRK06688 1127134009786 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134009787 substrate binding site [chemical binding]; other site 1127134009788 oxyanion hole (OAH) forming residues; other site 1127134009789 trimer interface [polypeptide binding]; other site 1127134009790 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1127134009791 nudix motif; other site 1127134009792 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1127134009793 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134009794 Walker A/P-loop; other site 1127134009795 ATP binding site [chemical binding]; other site 1127134009796 Q-loop/lid; other site 1127134009797 ABC transporter signature motif; other site 1127134009798 Walker B; other site 1127134009799 D-loop; other site 1127134009800 H-loop/switch region; other site 1127134009801 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1127134009802 dimer interface [polypeptide binding]; other site 1127134009803 putative active site [active] 1127134009804 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1127134009805 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1127134009806 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1127134009807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134009808 motif II; other site 1127134009809 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1127134009810 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1127134009811 D-pathway; other site 1127134009812 Putative ubiquinol binding site [chemical binding]; other site 1127134009813 Low-spin heme (heme b) binding site [chemical binding]; other site 1127134009814 Putative water exit pathway; other site 1127134009815 Binuclear center (heme o3/CuB) [ion binding]; other site 1127134009816 K-pathway; other site 1127134009817 Putative proton exit pathway; other site 1127134009818 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1127134009819 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1127134009820 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134009821 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1127134009822 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1127134009823 siderophore binding site; other site 1127134009824 acyl-CoA synthetase; Validated; Region: PRK08316 1127134009825 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134009826 Condensation domain; Region: Condensation; pfam00668 1127134009827 peptide synthase; Provisional; Region: PRK12316 1127134009828 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134009829 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134009830 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1127134009831 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134009832 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134009833 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134009834 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134009835 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134009836 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1127134009837 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1127134009838 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134009839 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1127134009840 Walker A/P-loop; other site 1127134009841 ATP binding site [chemical binding]; other site 1127134009842 Q-loop/lid; other site 1127134009843 ABC transporter signature motif; other site 1127134009844 Walker B; other site 1127134009845 D-loop; other site 1127134009846 H-loop/switch region; other site 1127134009847 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134009848 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134009849 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 1127134009850 putative active site [active] 1127134009851 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1127134009852 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1127134009853 dimer interface [polypeptide binding]; other site 1127134009854 putative radical transfer pathway; other site 1127134009855 diiron center [ion binding]; other site 1127134009856 tyrosyl radical; other site 1127134009857 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1127134009858 MgtE intracellular N domain; Region: MgtE_N; cl15244 1127134009859 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1127134009860 Divalent cation transporter; Region: MgtE; cl00786 1127134009861 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1127134009862 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134009863 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1127134009864 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134009865 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1127134009866 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134009867 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134009868 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1127134009869 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1127134009870 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1127134009871 active site 1127134009872 dimer interface [polypeptide binding]; other site 1127134009873 catalytic residues [active] 1127134009874 effector binding site; other site 1127134009875 R2 peptide binding site; other site 1127134009876 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134009877 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1127134009878 catalytic residues [active] 1127134009879 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134009880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134009881 Helix-turn-helix domains; Region: HTH; cl00088 1127134009882 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1127134009883 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1127134009884 homodimer interface [polypeptide binding]; other site 1127134009885 NAD binding pocket [chemical binding]; other site 1127134009886 ATP binding pocket [chemical binding]; other site 1127134009887 Mg binding site [ion binding]; other site 1127134009888 active-site loop [active] 1127134009889 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1127134009890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134009891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134009892 YCII-related domain; Region: YCII; cl00999 1127134009893 YCII-related domain; Region: YCII; cl00999 1127134009894 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1127134009895 MoaE interaction surface [polypeptide binding]; other site 1127134009896 MoeB interaction surface [polypeptide binding]; other site 1127134009897 thiocarboxylated glycine; other site 1127134009898 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1127134009899 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127134009900 FeS/SAM binding site; other site 1127134009901 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1127134009902 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1127134009903 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1127134009904 dimer interface [polypeptide binding]; other site 1127134009905 putative functional site; other site 1127134009906 putative MPT binding site; other site 1127134009907 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 1127134009908 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 1127134009909 trimer interface [polypeptide binding]; other site 1127134009910 dimer interface [polypeptide binding]; other site 1127134009911 putative active site [active] 1127134009912 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1127134009913 MPT binding site; other site 1127134009914 trimer interface [polypeptide binding]; other site 1127134009915 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1127134009916 MoaE homodimer interface [polypeptide binding]; other site 1127134009917 MoaD interaction [polypeptide binding]; other site 1127134009918 active site residues [active] 1127134009919 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1127134009920 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127134009921 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1127134009922 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134009923 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1127134009924 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1127134009925 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1127134009926 active site 1127134009927 metal binding site [ion binding]; metal-binding site 1127134009928 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1127134009929 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134009930 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134009931 DNA binding residues [nucleotide binding] 1127134009932 short chain dehydrogenase; Provisional; Region: PRK08251 1127134009933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134009934 NAD(P) binding site [chemical binding]; other site 1127134009935 active site 1127134009936 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134009937 CoenzymeA binding site [chemical binding]; other site 1127134009938 subunit interaction site [polypeptide binding]; other site 1127134009939 PHB binding site; other site 1127134009940 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1127134009941 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134009942 CoenzymeA binding site [chemical binding]; other site 1127134009943 subunit interaction site [polypeptide binding]; other site 1127134009944 PHB binding site; other site 1127134009945 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1127134009946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134009947 metabolite-proton symporter; Region: 2A0106; TIGR00883 1127134009948 putative substrate translocation pore; other site 1127134009949 bile acid transporter; Region: bass; TIGR00841 1127134009950 Membrane transport protein; Region: Mem_trans; cl09117 1127134009951 peptide synthase; Provisional; Region: PRK12467 1127134009952 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134009953 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134009954 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134009955 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134009956 thioester reductase domain; Region: Thioester-redct; TIGR01746 1127134009957 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1127134009958 putative NAD(P) binding site [chemical binding]; other site 1127134009959 active site 1127134009960 putative substrate binding site [chemical binding]; other site 1127134009961 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1127134009962 Moco binding site; other site 1127134009963 metal coordination site [ion binding]; other site 1127134009964 dimerization interface [polypeptide binding]; other site 1127134009965 LexA repressor; Validated; Region: PRK00215 1127134009966 Helix-turn-helix domains; Region: HTH; cl00088 1127134009967 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1127134009968 Catalytic site [active] 1127134009969 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134009970 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134009971 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1127134009972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134009973 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134009974 Helix-turn-helix domains; Region: HTH; cl00088 1127134009975 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1127134009976 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1127134009977 homodimer interface [polypeptide binding]; other site 1127134009978 substrate-cofactor binding pocket; other site 1127134009979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134009980 catalytic residue [active] 1127134009981 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1127134009982 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1127134009983 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1127134009984 spermidine synthase; Provisional; Region: PRK03612 1127134009985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134009986 Putative esterase; Region: Esterase; pfam00756 1127134009987 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134009988 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1127134009989 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1127134009990 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1127134009991 Isochorismatase family; Region: Isochorismatase; pfam00857 1127134009992 catalytic triad [active] 1127134009993 conserved cis-peptide bond; other site 1127134009994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134009995 NAD(P) binding site [chemical binding]; other site 1127134009996 active site 1127134009997 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134009998 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1127134009999 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1127134010000 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134010001 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1127134010002 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1127134010003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134010004 NAD(P) binding site [chemical binding]; other site 1127134010005 active site 1127134010006 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134010007 active site 2 [active] 1127134010008 active site 1 [active] 1127134010009 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1127134010010 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1127134010011 dimer interface [polypeptide binding]; other site 1127134010012 active site 1127134010013 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134010014 active site 2 [active] 1127134010015 active site 1 [active] 1127134010016 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1127134010017 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1127134010018 dimer interface [polypeptide binding]; other site 1127134010019 active site 1127134010020 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1127134010021 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1127134010022 dimer interface [polypeptide binding]; other site 1127134010023 active site 1127134010024 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1127134010025 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1127134010026 active site 1127134010027 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1127134010028 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1127134010029 active site 1127134010030 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1127134010031 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1127134010032 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1127134010033 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1127134010034 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 1127134010035 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134010036 Helix-turn-helix domains; Region: HTH; cl00088 1127134010037 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1127134010038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134010039 putative substrate translocation pore; other site 1127134010040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1127134010041 Helix-turn-helix domains; Region: HTH; cl00088 1127134010042 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1127134010043 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134010044 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134010045 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1127134010046 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134010047 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 1127134010048 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1127134010049 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134010050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134010051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134010052 non-specific DNA binding site [nucleotide binding]; other site 1127134010053 salt bridge; other site 1127134010054 sequence-specific DNA binding site [nucleotide binding]; other site 1127134010055 Domain of unknown function (DUF955); Region: DUF955; cl01076 1127134010056 haloalkane dehalogenase; Provisional; Region: PRK03592 1127134010057 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1127134010058 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134010059 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134010060 multicopper oxidase; Provisional; Region: PRK10965 1127134010061 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1127134010062 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1127134010063 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1127134010064 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1127134010065 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127134010066 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127134010067 active site 1127134010068 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1127134010069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134010070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134010071 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1127134010072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134010073 Helix-turn-helix domains; Region: HTH; cl00088 1127134010074 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1127134010075 substrate binding site [chemical binding]; other site 1127134010076 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1127134010077 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1127134010078 putative di-iron ligands [ion binding]; other site 1127134010079 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1127134010080 Protein of unknown function, DUF488; Region: DUF488; cl01246 1127134010081 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1127134010082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134010083 motif II; other site 1127134010084 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134010085 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1127134010086 catalytic residues [active] 1127134010087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134010088 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127134010089 putative substrate translocation pore; other site 1127134010090 phosphoglucomutase; Validated; Region: PRK07564 1127134010091 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1127134010092 active site 1127134010093 substrate binding site [chemical binding]; other site 1127134010094 metal binding site [ion binding]; metal-binding site 1127134010095 CrcB-like protein; Region: CRCB; cl09114 1127134010096 CrcB-like protein; Region: CRCB; cl09114 1127134010097 Secretory lipase; Region: LIP; pfam03583 1127134010098 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1127134010099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134010100 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1127134010101 Helix-turn-helix domains; Region: HTH; cl00088 1127134010102 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1127134010103 FAD binding domain; Region: FAD_binding_4; pfam01565 1127134010104 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 1127134010105 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1127134010106 NAD-dependent deacetylase; Provisional; Region: PRK00481 1127134010107 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1127134010108 NAD+ binding site [chemical binding]; other site 1127134010109 substrate binding site [chemical binding]; other site 1127134010110 Zn binding site [ion binding]; other site 1127134010111 Asp23 family; Region: Asp23; cl00574 1127134010112 Asp23 family; Region: Asp23; cl00574 1127134010113 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1127134010114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134010115 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134010116 DNA binding residues [nucleotide binding] 1127134010117 Helix-turn-helix domains; Region: HTH; cl00088 1127134010118 Secretory lipase; Region: LIP; pfam03583 1127134010119 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1127134010120 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1127134010121 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1127134010122 SmpB-tmRNA interface; other site 1127134010123 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127134010124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134010125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134010126 Helix-turn-helix domains; Region: HTH; cl00088 1127134010127 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 1127134010128 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1127134010129 active site 1127134010130 metal binding site [ion binding]; metal-binding site 1127134010131 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1127134010132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134010133 ATP binding site [chemical binding]; other site 1127134010134 putative Mg++ binding site [ion binding]; other site 1127134010135 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134010136 nucleotide binding region [chemical binding]; other site 1127134010137 ATP-binding site [chemical binding]; other site 1127134010138 RQC domain; Region: RQC; cl09632 1127134010139 HRDC domain; Region: HRDC; cl02578 1127134010140 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1127134010141 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134010142 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1127134010143 active site 1127134010144 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134010145 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1127134010146 RF-1 domain; Region: RF-1; cl02875 1127134010147 RF-1 domain; Region: RF-1; cl02875 1127134010148 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1127134010149 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1127134010150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134010151 Walker A/P-loop; other site 1127134010152 ATP binding site [chemical binding]; other site 1127134010153 Q-loop/lid; other site 1127134010154 ABC transporter signature motif; other site 1127134010155 Walker B; other site 1127134010156 D-loop; other site 1127134010157 H-loop/switch region; other site 1127134010158 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1127134010159 FtsX-like permease family; Region: FtsX; cl15850 1127134010160 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134010161 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134010162 active site 1127134010163 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134010164 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134010165 active site 1127134010166 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1127134010167 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134010168 DNA binding residues [nucleotide binding] 1127134010169 Helix-turn-helix domains; Region: HTH; cl00088 1127134010170 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1127134010171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134010172 putative substrate translocation pore; other site 1127134010173 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1127134010174 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1127134010175 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1127134010176 Helix-turn-helix domains; Region: HTH; cl00088 1127134010177 AsnC family; Region: AsnC_trans_reg; pfam01037 1127134010178 AzlC protein; Region: AzlC; cl00570 1127134010179 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1127134010180 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1127134010181 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1127134010182 catalytic residues [active] 1127134010183 Protein of unknown function (DUF419); Region: DUF419; cl15265 1127134010184 Glutaminase; Region: Glutaminase; cl00907 1127134010185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134010186 putative substrate translocation pore; other site 1127134010187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134010188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134010189 NlpC/P60 family; Region: NLPC_P60; cl11438 1127134010190 acyl-CoA synthetase; Validated; Region: PRK07788 1127134010191 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134010192 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134010193 acyl-CoA synthetase; Validated; Region: PRK07788 1127134010194 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134010195 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134010196 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1127134010197 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1127134010198 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1127134010199 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1127134010200 galactokinase; Provisional; Region: PRK03817 1127134010201 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1127134010202 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 1127134010203 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1127134010204 metal binding site [ion binding]; metal-binding site 1127134010205 active site 1127134010206 I-site; other site 1127134010207 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1127134010208 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134010209 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134010210 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1127134010211 PQQ-like domain; Region: PQQ_2; pfam13360 1127134010212 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1127134010213 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1127134010214 intersubunit interface [polypeptide binding]; other site 1127134010215 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127134010216 ABC-ATPase subunit interface; other site 1127134010217 dimer interface [polypeptide binding]; other site 1127134010218 putative PBP binding regions; other site 1127134010219 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1127134010220 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134010221 Walker A/P-loop; other site 1127134010222 ATP binding site [chemical binding]; other site 1127134010223 Q-loop/lid; other site 1127134010224 ABC transporter signature motif; other site 1127134010225 Walker B; other site 1127134010226 D-loop; other site 1127134010227 H-loop/switch region; other site 1127134010228 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1127134010229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134010230 Helix-turn-helix domains; Region: HTH; cl00088 1127134010231 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1127134010232 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1127134010233 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1127134010234 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1127134010235 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1127134010236 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1127134010237 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 1127134010238 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1127134010239 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134010240 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1127134010241 active site 1127134010242 ATP binding site [chemical binding]; other site 1127134010243 Transcription factor WhiB; Region: Whib; pfam02467 1127134010244 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1127134010245 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134010246 Family description; Region: UvrD_C_2; cl15862 1127134010247 HRDC domain; Region: HRDC; cl02578 1127134010248 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1127134010249 catalytic residues [active] 1127134010250 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1127134010251 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1127134010252 putative NADH binding site [chemical binding]; other site 1127134010253 putative active site [active] 1127134010254 nudix motif; other site 1127134010255 putative metal binding site [ion binding]; other site 1127134010256 Ion channel; Region: Ion_trans_2; cl11596 1127134010257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134010258 Predicted membrane protein [Function unknown]; Region: COG4270 1127134010259 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1127134010260 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1127134010261 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134010262 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1127134010263 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1127134010264 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1127134010265 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134010266 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134010267 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1127134010268 active site 1127134010269 DNA binding site [nucleotide binding] 1127134010270 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134010271 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134010272 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1127134010273 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134010274 active site 1127134010275 metal binding site [ion binding]; metal-binding site 1127134010276 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1127134010277 GTP binding site; other site 1127134010278 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1127134010279 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1127134010280 dimer interface [polypeptide binding]; other site 1127134010281 putative functional site; other site 1127134010282 putative MPT binding site; other site 1127134010283 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1127134010284 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1127134010285 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1127134010286 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1127134010287 [4Fe-4S] binding site [ion binding]; other site 1127134010288 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1127134010289 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1127134010290 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1127134010291 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1127134010292 molybdopterin cofactor binding site; other site 1127134010293 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1127134010294 4Fe-4S binding domain; Region: Fer4; cl02805 1127134010295 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1127134010296 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1127134010297 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134010298 dimerization interface [polypeptide binding]; other site 1127134010299 putative DNA binding site [nucleotide binding]; other site 1127134010300 putative Zn2+ binding site [ion binding]; other site 1127134010301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134010302 putative substrate translocation pore; other site 1127134010303 TfoX N-terminal domain; Region: TfoX_N; cl01167 1127134010304 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1127134010305 dimer interface [polypeptide binding]; other site 1127134010306 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134010307 metal binding site [ion binding]; metal-binding site 1127134010308 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1127134010309 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1127134010310 putative active site [active] 1127134010311 putative metal binding site [ion binding]; other site 1127134010312 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1127134010313 putative active site [active] 1127134010314 putative CoA binding site [chemical binding]; other site 1127134010315 nudix motif; other site 1127134010316 metal binding site [ion binding]; metal-binding site 1127134010317 Predicted esterase [General function prediction only]; Region: COG0627 1127134010318 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134010319 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1127134010320 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1127134010321 putative active site [active] 1127134010322 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1127134010323 putative active site [active] 1127134010324 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1127134010325 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1127134010326 active site 1127134010327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127134010328 DNA binding site [nucleotide binding] 1127134010329 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1127134010330 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1127134010331 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1127134010332 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1127134010333 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1127134010334 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1127134010335 cyanate transporter; Region: CynX; TIGR00896 1127134010336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134010337 putative substrate translocation pore; other site 1127134010338 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1127134010339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134010340 DNA-binding site [nucleotide binding]; DNA binding site 1127134010341 FCD domain; Region: FCD; cl11656 1127134010342 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1127134010343 TIGR02569 family protein; Region: TIGR02569_actnb 1127134010344 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1127134010345 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1127134010346 ATP binding site [chemical binding]; other site 1127134010347 substrate interface [chemical binding]; other site 1127134010348 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1127134010349 active site residue [active] 1127134010350 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1127134010351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134010352 Helix-turn-helix domains; Region: HTH; cl00088 1127134010353 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1127134010354 YceI-like domain; Region: YceI; cl01001 1127134010355 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1127134010356 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 1127134010357 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1127134010358 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1127134010359 ATP binding site [chemical binding]; other site 1127134010360 Mg++ binding site [ion binding]; other site 1127134010361 motif III; other site 1127134010362 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134010363 nucleotide binding region [chemical binding]; other site 1127134010364 ATP-binding site [chemical binding]; other site 1127134010365 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127134010366 catalytic core [active] 1127134010367 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1127134010368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127134010369 Coenzyme A binding pocket [chemical binding]; other site 1127134010370 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1127134010371 Active_site [active] 1127134010372 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1127134010373 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1127134010374 Transcription factor WhiB; Region: Whib; pfam02467 1127134010375 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1127134010376 PAS domain S-box; Region: sensory_box; TIGR00229 1127134010377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1127134010378 Histidine kinase; Region: HisKA_2; cl06527 1127134010379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134010380 ATP binding site [chemical binding]; other site 1127134010381 Mg2+ binding site [ion binding]; other site 1127134010382 G-X-G motif; other site 1127134010383 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1127134010384 carboxyltransferase (CT) interaction site; other site 1127134010385 biotinylation site [posttranslational modification]; other site 1127134010386 Putative zinc-finger; Region: zf-HC2; cl15806 1127134010387 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1127134010388 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134010389 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134010390 DNA binding residues [nucleotide binding] 1127134010391 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1127134010392 putative deacylase active site [active] 1127134010393 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1127134010394 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134010395 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1127134010396 NAD(P) binding site [chemical binding]; other site 1127134010397 catalytic residues [active] 1127134010398 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1127134010399 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 1127134010400 hinge; other site 1127134010401 active site 1127134010402 Predicted GTPases [General function prediction only]; Region: COG1162 1127134010403 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1127134010404 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1127134010405 GTP/Mg2+ binding site [chemical binding]; other site 1127134010406 G4 box; other site 1127134010407 G5 box; other site 1127134010408 G1 box; other site 1127134010409 Switch I region; other site 1127134010410 G2 box; other site 1127134010411 G3 box; other site 1127134010412 Switch II region; other site 1127134010413 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1127134010414 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 1127134010415 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1127134010416 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1127134010417 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1127134010418 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1127134010419 FAD binding pocket [chemical binding]; other site 1127134010420 FAD binding motif [chemical binding]; other site 1127134010421 phosphate binding motif [ion binding]; other site 1127134010422 beta-alpha-beta structure motif; other site 1127134010423 NAD binding pocket [chemical binding]; other site 1127134010424 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1127134010425 catalytic loop [active] 1127134010426 iron binding site [ion binding]; other site 1127134010427 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1127134010428 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1127134010429 putative di-iron ligands [ion binding]; other site 1127134010430 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1127134010431 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1127134010432 putative di-iron ligands [ion binding]; other site 1127134010433 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1127134010434 putative FMN binding site [chemical binding]; other site 1127134010435 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1127134010436 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1127134010437 dimer interface [polypeptide binding]; other site 1127134010438 active site 1127134010439 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 1127134010440 30S subunit binding site; other site 1127134010441 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1127134010442 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127134010443 active site 1127134010444 lipoprotein LpqB; Provisional; Region: PRK13616 1127134010445 Sporulation and spore germination; Region: Germane; cl11253 1127134010446 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1127134010447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127134010448 dimer interface [polypeptide binding]; other site 1127134010449 phosphorylation site [posttranslational modification] 1127134010450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134010451 ATP binding site [chemical binding]; other site 1127134010452 Mg2+ binding site [ion binding]; other site 1127134010453 G-X-G motif; other site 1127134010454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127134010455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134010456 active site 1127134010457 phosphorylation site [posttranslational modification] 1127134010458 intermolecular recognition site; other site 1127134010459 dimerization interface [polypeptide binding]; other site 1127134010460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127134010461 DNA binding site [nucleotide binding] 1127134010462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134010463 active site 1127134010464 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1127134010465 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 1127134010466 oligomerization interface [polypeptide binding]; other site 1127134010467 active site 1127134010468 NAD+ binding site [chemical binding]; other site 1127134010469 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1127134010470 Di-iron ligands [ion binding]; other site 1127134010471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134010472 Helix-turn-helix domains; Region: HTH; cl00088 1127134010473 Rubredoxin [Energy production and conversion]; Region: COG1773 1127134010474 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1127134010475 iron binding site [ion binding]; other site 1127134010476 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1127134010477 Di-iron ligands [ion binding]; other site 1127134010478 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1127134010479 nudix motif; other site 1127134010480 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1127134010481 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1127134010482 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1127134010483 putative FMN binding site [chemical binding]; other site 1127134010484 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 1127134010485 phosphate binding site [ion binding]; other site 1127134010486 Transcription factor WhiB; Region: Whib; pfam02467 1127134010487 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1127134010488 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1127134010489 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1127134010490 active site 1127134010491 substrate binding site [chemical binding]; other site 1127134010492 metal binding site [ion binding]; metal-binding site 1127134010493 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1127134010494 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1127134010495 Cation efflux family; Region: Cation_efflux; cl00316 1127134010496 Htaa; Region: HtaA; pfam04213 1127134010497 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1127134010498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134010499 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1127134010500 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1127134010501 active site 1127134010502 Substrate binding site; other site 1127134010503 Mg++ binding site; other site 1127134010504 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1127134010505 putative trimer interface [polypeptide binding]; other site 1127134010506 putative CoA binding site [chemical binding]; other site 1127134010507 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1127134010508 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1127134010509 Probable Catalytic site; other site 1127134010510 metal-binding site 1127134010511 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1127134010512 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1127134010513 NADP binding site [chemical binding]; other site 1127134010514 active site 1127134010515 putative substrate binding site [chemical binding]; other site 1127134010516 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1127134010517 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1127134010518 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134010519 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134010520 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1127134010521 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134010522 substrate binding pocket [chemical binding]; other site 1127134010523 catalytic triad [active] 1127134010524 Rdx family; Region: Rdx; cl01407 1127134010525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 1127134010526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134010527 ABC transporter signature motif; other site 1127134010528 Walker B; other site 1127134010529 D-loop; other site 1127134010530 H-loop/switch region; other site 1127134010531 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134010532 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1127134010533 metal ion-dependent adhesion site (MIDAS); other site 1127134010534 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1127134010535 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1127134010536 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1127134010537 FtsX-like permease family; Region: FtsX; cl15850 1127134010538 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1127134010539 FtsX-like permease family; Region: FtsX; cl15850 1127134010540 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1127134010541 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1127134010542 Walker A/P-loop; other site 1127134010543 ATP binding site [chemical binding]; other site 1127134010544 Q-loop/lid; other site 1127134010545 ABC transporter signature motif; other site 1127134010546 Walker B; other site 1127134010547 D-loop; other site 1127134010548 H-loop/switch region; other site 1127134010549 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134010550 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134010551 active site 1127134010552 ATP binding site [chemical binding]; other site 1127134010553 substrate binding site [chemical binding]; other site 1127134010554 activation loop (A-loop); other site 1127134010555 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134010556 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134010557 active site 1127134010558 ATP binding site [chemical binding]; other site 1127134010559 substrate binding site [chemical binding]; other site 1127134010560 activation loop (A-loop); other site 1127134010561 endonuclease IV; Provisional; Region: PRK01060 1127134010562 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1127134010563 AP (apurinic/apyrimidinic) site pocket; other site 1127134010564 DNA interaction; other site 1127134010565 Metal-binding active site; metal-binding site 1127134010566 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1127134010567 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1127134010568 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1127134010569 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1127134010570 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1127134010571 active site 1127134010572 catalytic residues [active] 1127134010573 metal binding site [ion binding]; metal-binding site 1127134010574 mce related protein; Region: MCE; pfam02470 1127134010575 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1127134010576 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134010577 Cytochrome P450; Region: p450; pfam00067 1127134010578 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1127134010579 catalytic residues [active] 1127134010580 dimer interface [polypeptide binding]; other site 1127134010581 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134010582 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134010583 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1127134010584 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1127134010585 classical (c) SDRs; Region: SDR_c; cd05233 1127134010586 NAD(P) binding site [chemical binding]; other site 1127134010587 active site 1127134010588 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134010589 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134010590 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1127134010591 NAD binding site [chemical binding]; other site 1127134010592 catalytic residues [active] 1127134010593 short chain dehydrogenase; Provisional; Region: PRK07774 1127134010594 classical (c) SDRs; Region: SDR_c; cd05233 1127134010595 NAD(P) binding site [chemical binding]; other site 1127134010596 active site 1127134010597 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1127134010598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134010599 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1127134010600 hypothetical protein; Validated; Region: PRK07121 1127134010601 Helix-turn-helix domains; Region: HTH; cl00088 1127134010602 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134010603 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1127134010604 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1127134010605 putative [Fe4-S4] binding site [ion binding]; other site 1127134010606 putative molybdopterin cofactor binding site [chemical binding]; other site 1127134010607 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1127134010608 putative molybdopterin cofactor binding site; other site 1127134010609 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134010610 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134010611 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134010612 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1127134010613 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1127134010614 NAD binding site [chemical binding]; other site 1127134010615 catalytic Zn binding site [ion binding]; other site 1127134010616 substrate binding site [chemical binding]; other site 1127134010617 structural Zn binding site [ion binding]; other site 1127134010618 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134010619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134010620 Helix-turn-helix domains; Region: HTH; cl00088 1127134010621 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127134010622 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134010623 Walker A/P-loop; other site 1127134010624 ATP binding site [chemical binding]; other site 1127134010625 Q-loop/lid; other site 1127134010626 ABC transporter signature motif; other site 1127134010627 Walker B; other site 1127134010628 D-loop; other site 1127134010629 H-loop/switch region; other site 1127134010630 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127134010631 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1127134010632 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134010633 Walker A/P-loop; other site 1127134010634 ATP binding site [chemical binding]; other site 1127134010635 Q-loop/lid; other site 1127134010636 ABC transporter signature motif; other site 1127134010637 Walker B; other site 1127134010638 D-loop; other site 1127134010639 H-loop/switch region; other site 1127134010640 Helix-turn-helix domains; Region: HTH; cl00088 1127134010641 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134010642 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134010643 trimer interface [polypeptide binding]; other site 1127134010644 oxyanion hole (OAH) forming residues; other site 1127134010645 PaaX-like protein; Region: PaaX; pfam07848 1127134010646 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1127134010647 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1127134010648 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1127134010649 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134010650 active site 1127134010651 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1127134010652 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1127134010653 active site 1127134010654 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1127134010655 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134010656 active site 1127134010657 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1127134010658 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134010659 Helix-turn-helix domains; Region: HTH; cl00088 1127134010660 Predicted transcriptional regulator [Transcription]; Region: COG2378 1127134010661 WYL domain; Region: WYL; cl14852 1127134010662 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134010663 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134010664 EspG family; Region: ESX-1_EspG; pfam14011 1127134010665 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1127134010666 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1127134010667 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1127134010668 putative active site [active] 1127134010669 catalytic triad [active] 1127134010670 putative dimer interface [polypeptide binding]; other site 1127134010671 helicase 45; Provisional; Region: PTZ00424 1127134010672 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1127134010673 ATP binding site [chemical binding]; other site 1127134010674 Mg++ binding site [ion binding]; other site 1127134010675 motif III; other site 1127134010676 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134010677 nucleotide binding region [chemical binding]; other site 1127134010678 ATP-binding site [chemical binding]; other site 1127134010679 DbpA RNA binding domain; Region: DbpA; pfam03880 1127134010680 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1127134010681 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134010682 Family description; Region: UvrD_C_2; cl15862 1127134010683 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1127134010684 active site 1127134010685 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1127134010686 dimer interface [polypeptide binding]; other site 1127134010687 substrate binding site [chemical binding]; other site 1127134010688 catalytic residue [active] 1127134010689 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1127134010690 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1127134010691 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1127134010692 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134010693 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1127134010694 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134010695 substrate binding site [chemical binding]; other site 1127134010696 oxyanion hole (OAH) forming residues; other site 1127134010697 trimer interface [polypeptide binding]; other site 1127134010698 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1127134010699 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1127134010700 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1127134010701 putative dimer interface [polypeptide binding]; other site 1127134010702 N-terminal domain interface [polypeptide binding]; other site 1127134010703 putative substrate binding pocket (H-site) [chemical binding]; other site 1127134010704 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127134010705 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134010706 Walker A/P-loop; other site 1127134010707 ATP binding site [chemical binding]; other site 1127134010708 Q-loop/lid; other site 1127134010709 ABC transporter signature motif; other site 1127134010710 Walker B; other site 1127134010711 D-loop; other site 1127134010712 H-loop/switch region; other site 1127134010713 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1127134010714 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 1127134010715 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 1127134010716 Walker A/P-loop; other site 1127134010717 ATP binding site [chemical binding]; other site 1127134010718 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134010719 Q-loop/lid; other site 1127134010720 ABC transporter signature motif; other site 1127134010721 Walker B; other site 1127134010722 D-loop; other site 1127134010723 H-loop/switch region; other site 1127134010724 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1127134010725 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134010726 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1127134010727 Walker A/P-loop; other site 1127134010728 ATP binding site [chemical binding]; other site 1127134010729 Q-loop/lid; other site 1127134010730 ABC transporter signature motif; other site 1127134010731 Walker B; other site 1127134010732 D-loop; other site 1127134010733 H-loop/switch region; other site 1127134010734 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1127134010735 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1127134010736 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1127134010737 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1127134010738 TPP-binding site [chemical binding]; other site 1127134010739 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1127134010740 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1127134010741 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1127134010742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134010743 Helix-turn-helix domains; Region: HTH; cl00088 1127134010744 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134010745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134010746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134010747 short chain dehydrogenase; Provisional; Region: PRK07832 1127134010748 NAD(P) binding site [chemical binding]; other site 1127134010749 active site 1127134010750 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1127134010751 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134010752 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1127134010753 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134010754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134010755 putative substrate translocation pore; other site 1127134010756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134010757 Helix-turn-helix domains; Region: HTH; cl00088 1127134010758 NMT1-like family; Region: NMT1_2; cl15260 1127134010759 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1127134010760 NMT1-like family; Region: NMT1_2; cl15260 1127134010761 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1127134010762 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1127134010763 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 1127134010764 Walker A/P-loop; other site 1127134010765 ATP binding site [chemical binding]; other site 1127134010766 Q-loop/lid; other site 1127134010767 ABC transporter signature motif; other site 1127134010768 Walker B; other site 1127134010769 D-loop; other site 1127134010770 H-loop/switch region; other site 1127134010771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1127134010772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1127134010773 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1127134010774 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1127134010775 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1127134010776 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1127134010777 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1127134010778 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1127134010779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134010780 NAD(P) binding pocket [chemical binding]; other site 1127134010781 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1127134010782 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1127134010783 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1127134010784 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1127134010785 MgtE intracellular N domain; Region: MgtE_N; cl15244 1127134010786 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1127134010787 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1127134010788 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1127134010789 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1127134010790 catalytic residue [active] 1127134010791 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1127134010792 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1127134010793 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1127134010794 Domain of unknown function DUF59; Region: DUF59; cl00941 1127134010795 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1127134010796 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1127134010797 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 1127134010798 DivIVA domain; Region: DivI1A_domain; TIGR03544 1127134010799 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1127134010800 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1127134010801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134010802 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1127134010803 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1127134010804 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1127134010805 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1127134010806 ligand binding site; other site 1127134010807 oligomer interface; other site 1127134010808 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1127134010809 dimer interface [polypeptide binding]; other site 1127134010810 N-terminal domain interface [polypeptide binding]; other site 1127134010811 sulfate 1 binding site; other site 1127134010812 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134010813 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127134010814 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1127134010815 Walker A/P-loop; other site 1127134010816 ATP binding site [chemical binding]; other site 1127134010817 Q-loop/lid; other site 1127134010818 ABC transporter signature motif; other site 1127134010819 Walker B; other site 1127134010820 D-loop; other site 1127134010821 H-loop/switch region; other site 1127134010822 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1127134010823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134010824 Helix-turn-helix domains; Region: HTH; cl00088 1127134010825 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1127134010826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134010827 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1127134010828 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134010829 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134010830 DNA binding residues [nucleotide binding] 1127134010831 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1127134010832 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1127134010833 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1127134010834 protein binding site [polypeptide binding]; other site 1127134010835 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1127134010836 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1127134010837 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1127134010838 active site 1127134010839 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1127134010840 dihydropteroate synthase; Region: DHPS; TIGR01496 1127134010841 substrate binding pocket [chemical binding]; other site 1127134010842 dimer interface [polypeptide binding]; other site 1127134010843 inhibitor binding site; inhibition site 1127134010844 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 1127134010845 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1127134010846 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134010847 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1127134010848 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1127134010849 succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900 1127134010850 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1127134010851 metal binding site [ion binding]; metal-binding site 1127134010852 putative dimer interface [polypeptide binding]; other site 1127134010853 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1127134010854 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1127134010855 putative trimer interface [polypeptide binding]; other site 1127134010856 putative CoA binding site [chemical binding]; other site 1127134010857 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134010858 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134010859 active site 1127134010860 ATP binding site [chemical binding]; other site 1127134010861 substrate binding site [chemical binding]; other site 1127134010862 activation loop (A-loop); other site 1127134010863 acyl-CoA synthetase; Validated; Region: PRK07787 1127134010864 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134010865 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134010866 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1127134010867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134010868 Helix-turn-helix domains; Region: HTH; cl00088 1127134010869 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1127134010870 Proline dehydrogenase; Region: Pro_dh; cl03282 1127134010871 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1127134010872 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134010873 NAD(P) binding site [chemical binding]; other site 1127134010874 catalytic residues [active] 1127134010875 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 1127134010876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127134010877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134010878 homodimer interface [polypeptide binding]; other site 1127134010879 catalytic residue [active] 1127134010880 Ferredoxin [Energy production and conversion]; Region: COG1146 1127134010881 4Fe-4S binding domain; Region: Fer4; cl02805 1127134010882 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1127134010883 FO synthase; Reviewed; Region: fbiC; PRK09234 1127134010884 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127134010885 FeS/SAM binding site; other site 1127134010886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127134010887 FeS/SAM binding site; other site 1127134010888 Bacterial PH domain; Region: DUF304; cl01348 1127134010889 Predicted membrane protein [Function unknown]; Region: COG3428 1127134010890 Bacterial PH domain; Region: DUF304; cl01348 1127134010891 Bacterial PH domain; Region: DUF304; cl01348 1127134010892 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1127134010893 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1127134010894 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1127134010895 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1127134010896 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1127134010897 G1 box; other site 1127134010898 putative GEF interaction site [polypeptide binding]; other site 1127134010899 GTP/Mg2+ binding site [chemical binding]; other site 1127134010900 Switch I region; other site 1127134010901 G2 box; other site 1127134010902 G3 box; other site 1127134010903 Switch II region; other site 1127134010904 G4 box; other site 1127134010905 G5 box; other site 1127134010906 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1127134010907 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1127134010908 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1127134010909 aromatic arch; other site 1127134010910 DCoH dimer interaction site [polypeptide binding]; other site 1127134010911 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1127134010912 DCoH tetramer interaction site [polypeptide binding]; other site 1127134010913 substrate binding site [chemical binding]; other site 1127134010914 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1127134010915 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1127134010916 active site 1127134010917 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 1127134010918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134010919 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1127134010920 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1127134010921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1127134010922 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1127134010923 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 1127134010924 Walker A/P-loop; other site 1127134010925 ATP binding site [chemical binding]; other site 1127134010926 Q-loop/lid; other site 1127134010927 ABC transporter signature motif; other site 1127134010928 Walker B; other site 1127134010929 D-loop; other site 1127134010930 H-loop/switch region; other site 1127134010931 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1127134010932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134010933 ABC-ATPase subunit interface; other site 1127134010934 NMT1-like family; Region: NMT1_2; cl15260 1127134010935 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1127134010936 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1127134010937 Helix-turn-helix domains; Region: HTH; cl00088 1127134010938 Helix-turn-helix domains; Region: HTH; cl00088 1127134010939 Predicted esterase [General function prediction only]; Region: COG0627 1127134010940 Protein of unknown function (DUF419); Region: DUF419; cl15265 1127134010941 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1127134010942 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134010943 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1127134010944 DoxX; Region: DoxX; cl00976 1127134010945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134010946 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1127134010947 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134010948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134010949 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1127134010950 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134010951 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1127134010952 oligomeric interface; other site 1127134010953 putative active site [active] 1127134010954 homodimer interface [polypeptide binding]; other site 1127134010955 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134010956 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134010957 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1127134010958 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 1127134010959 GTP-binding protein YchF; Reviewed; Region: PRK09601 1127134010960 YchF GTPase; Region: YchF; cd01900 1127134010961 G1 box; other site 1127134010962 GTP/Mg2+ binding site [chemical binding]; other site 1127134010963 Switch I region; other site 1127134010964 G2 box; other site 1127134010965 Switch II region; other site 1127134010966 G3 box; other site 1127134010967 G4 box; other site 1127134010968 G5 box; other site 1127134010969 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1127134010970 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1127134010971 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1127134010972 NAD(P) binding site [chemical binding]; other site 1127134010973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134010974 Helix-turn-helix domain; Region: HTH_18; pfam12833 1127134010975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134010976 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1127134010977 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134010978 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1127134010979 putative FMN binding site [chemical binding]; other site 1127134010980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134010981 dimer interface [polypeptide binding]; other site 1127134010982 conserved gate region; other site 1127134010983 putative PBP binding loops; other site 1127134010984 ABC-ATPase subunit interface; other site 1127134010985 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1127134010986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134010987 putative PBP binding loops; other site 1127134010988 dimer interface [polypeptide binding]; other site 1127134010989 ABC-ATPase subunit interface; other site 1127134010990 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1127134010991 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134010992 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1127134010993 Carbon starvation protein CstA; Region: CstA; pfam02554 1127134010994 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1127134010995 Protein of unknown function (DUF466); Region: DUF466; cl01082 1127134010996 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1127134010997 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1127134010998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134010999 AlkA N-terminal domain; Region: AlkA_N; cl05528 1127134011000 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1127134011001 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1127134011002 minor groove reading motif; other site 1127134011003 helix-hairpin-helix signature motif; other site 1127134011004 substrate binding pocket [chemical binding]; other site 1127134011005 active site 1127134011006 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1127134011007 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1127134011008 active site 1127134011009 DNA binding site [nucleotide binding] 1127134011010 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1127134011011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134011012 DNA-binding site [nucleotide binding]; DNA binding site 1127134011013 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127134011014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134011015 homodimer interface [polypeptide binding]; other site 1127134011016 catalytic residue [active] 1127134011017 Cupin domain; Region: Cupin_2; cl09118 1127134011018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134011019 Walker A/P-loop; other site 1127134011020 ATP binding site [chemical binding]; other site 1127134011021 Q-loop/lid; other site 1127134011022 Walker B; other site 1127134011023 D-loop; other site 1127134011024 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1127134011025 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 1127134011026 ABC transporter signature motif; other site 1127134011027 Walker B; other site 1127134011028 D-loop; other site 1127134011029 H-loop/switch region; other site 1127134011030 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1127134011031 active site 1127134011032 metal binding site [ion binding]; metal-binding site 1127134011033 DNA binding site [nucleotide binding] 1127134011034 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1127134011035 LytB protein; Region: LYTB; cl00507 1127134011036 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1127134011037 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1127134011038 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1127134011039 generic binding surface II; other site 1127134011040 generic binding surface I; other site 1127134011041 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 1127134011042 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 1127134011043 dimer interface [polypeptide binding]; other site 1127134011044 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134011045 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1127134011046 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1127134011047 putative active site [active] 1127134011048 LGFP repeat; Region: LGFP; pfam08310 1127134011049 LGFP repeat; Region: LGFP; pfam08310 1127134011050 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1127134011051 dinuclear metal binding motif [ion binding]; other site 1127134011052 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1127134011053 Class II fumarases; Region: Fumarase_classII; cd01362 1127134011054 active site 1127134011055 tetramer interface [polypeptide binding]; other site 1127134011056 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1127134011057 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1127134011058 putative active site [active] 1127134011059 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134011060 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1127134011061 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1127134011062 FMN binding site [chemical binding]; other site 1127134011063 substrate binding site [chemical binding]; other site 1127134011064 putative catalytic residue [active] 1127134011065 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1127134011066 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127134011067 active site 1127134011068 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127134011069 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134011070 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1127134011071 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1127134011072 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1127134011073 FMN-binding pocket [chemical binding]; other site 1127134011074 flavin binding motif; other site 1127134011075 phosphate binding motif [ion binding]; other site 1127134011076 beta-alpha-beta structure motif; other site 1127134011077 NAD binding pocket [chemical binding]; other site 1127134011078 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1127134011079 catalytic loop [active] 1127134011080 iron binding site [ion binding]; other site 1127134011081 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1127134011082 Helix-turn-helix domains; Region: HTH; cl00088 1127134011083 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1127134011084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134011085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134011086 YCII-related domain; Region: YCII; cl00999 1127134011087 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134011088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134011089 Helix-turn-helix domains; Region: HTH; cl00088 1127134011090 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1127134011091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134011092 NAD(P) binding site [chemical binding]; other site 1127134011093 active site 1127134011094 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1127134011095 Protein of unknown function (DUF779); Region: DUF779; cl01432 1127134011096 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1127134011097 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134011098 NAD(P) binding site [chemical binding]; other site 1127134011099 catalytic residues [active] 1127134011100 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1127134011101 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134011102 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1127134011103 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1127134011104 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134011105 Helix-turn-helix domains; Region: HTH; cl00088 1127134011106 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1127134011107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134011108 hypothetical protein; Provisional; Region: PRK07588 1127134011109 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1127134011110 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1127134011111 dimer interface [polypeptide binding]; other site 1127134011112 active site 1127134011113 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1127134011114 folate binding site [chemical binding]; other site 1127134011115 pantothenate kinase; Provisional; Region: PRK05439 1127134011116 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 1127134011117 ATP-binding site [chemical binding]; other site 1127134011118 CoA-binding site [chemical binding]; other site 1127134011119 Mg2+-binding site [ion binding]; other site 1127134011120 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1127134011121 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1127134011122 catalytic residue [active] 1127134011123 putative FPP diphosphate binding site; other site 1127134011124 putative FPP binding hydrophobic cleft; other site 1127134011125 dimer interface [polypeptide binding]; other site 1127134011126 putative IPP diphosphate binding site; other site 1127134011127 Haemolysin-III related; Region: HlyIII; cl03831 1127134011128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127134011129 dimerization interface [polypeptide binding]; other site 1127134011130 cyclase homology domain; Region: CHD; cd07302 1127134011131 nucleotidyl binding site; other site 1127134011132 metal binding site [ion binding]; metal-binding site 1127134011133 dimer interface [polypeptide binding]; other site 1127134011134 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1127134011135 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1127134011136 putative acyl-acceptor binding pocket; other site 1127134011137 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1127134011138 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1127134011139 catalytic residues [active] 1127134011140 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134011141 active site 1127134011142 metal binding site [ion binding]; metal-binding site 1127134011143 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134011144 metal binding site [ion binding]; metal-binding site 1127134011145 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127134011146 active site 1127134011147 metal binding site [ion binding]; metal-binding site 1127134011148 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134011149 DNA binding residues [nucleotide binding] 1127134011150 Predicted ATPase [General function prediction only]; Region: COG3903 1127134011151 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1127134011152 nudix motif; other site 1127134011153 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1127134011154 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1127134011155 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1127134011156 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1127134011157 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1127134011158 cystathionine gamma-synthase; Provisional; Region: PRK07811 1127134011159 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1127134011160 homodimer interface [polypeptide binding]; other site 1127134011161 substrate-cofactor binding pocket; other site 1127134011162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134011163 catalytic residue [active] 1127134011164 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134011165 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134011166 active site 1127134011167 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1127134011168 EspG family; Region: ESX-1_EspG; pfam14011 1127134011169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134011170 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134011171 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1127134011172 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1127134011173 dimer interface [polypeptide binding]; other site 1127134011174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134011175 catalytic residue [active] 1127134011176 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1127134011177 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1127134011178 active site 1127134011179 catalytic triad [active] 1127134011180 oxyanion hole [active] 1127134011181 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1127134011182 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1127134011183 dimer interface [polypeptide binding]; other site 1127134011184 active site 1127134011185 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 1127134011186 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1127134011187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134011188 Domain of unknown function (DUF305); Region: DUF305; cl15795 1127134011189 Predicted membrane protein [Function unknown]; Region: COG2311 1127134011190 Protein of unknown function (DUF418); Region: DUF418; cl12135 1127134011191 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134011192 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134011193 active site 1127134011194 amino acid transporter; Region: 2A0306; TIGR00909 1127134011195 Spore germination protein; Region: Spore_permease; cl15802 1127134011196 Spore germination protein; Region: Spore_permease; cl15802 1127134011197 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 1127134011198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1127134011199 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1127134011200 hydrophobic ligand binding site; other site 1127134011201 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 1127134011202 Protein of unknown function (DUF501); Region: DUF501; cl00652 1127134011203 enolase; Provisional; Region: eno; PRK00077 1127134011204 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1127134011205 dimer interface [polypeptide binding]; other site 1127134011206 metal binding site [ion binding]; metal-binding site 1127134011207 substrate binding pocket [chemical binding]; other site 1127134011208 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1127134011209 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1127134011210 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1127134011211 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134011212 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1127134011213 Walker A/P-loop; other site 1127134011214 ATP binding site [chemical binding]; other site 1127134011215 Q-loop/lid; other site 1127134011216 ABC transporter signature motif; other site 1127134011217 Walker B; other site 1127134011218 D-loop; other site 1127134011219 H-loop/switch region; other site 1127134011220 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1127134011221 Walker A/P-loop; other site 1127134011222 ATP binding site [chemical binding]; other site 1127134011223 Q-loop/lid; other site 1127134011224 ABC transporter signature motif; other site 1127134011225 Walker B; other site 1127134011226 D-loop; other site 1127134011227 H-loop/switch region; other site 1127134011228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134011229 dimer interface [polypeptide binding]; other site 1127134011230 conserved gate region; other site 1127134011231 putative PBP binding loops; other site 1127134011232 ABC-ATPase subunit interface; other site 1127134011233 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1127134011234 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1127134011235 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1127134011236 substrate binding pocket [chemical binding]; other site 1127134011237 active site 1127134011238 iron coordination sites [ion binding]; other site 1127134011239 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1127134011240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134011241 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1127134011242 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 1127134011243 dimer interface [polypeptide binding]; other site 1127134011244 active site 1127134011245 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1127134011246 catalytic residues [active] 1127134011247 substrate binding site [chemical binding]; other site 1127134011248 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1127134011249 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1127134011250 dimer interface [polypeptide binding]; other site 1127134011251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134011252 catalytic residue [active] 1127134011253 multidrug efflux protein; Reviewed; Region: PRK01766 1127134011254 MatE; Region: MatE; cl10513 1127134011255 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134011256 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1127134011257 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134011258 putative metal binding site [ion binding]; other site 1127134011259 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127134011260 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1127134011261 homodimer interface [polypeptide binding]; other site 1127134011262 metal binding site [ion binding]; metal-binding site 1127134011263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134011264 Helix-turn-helix domains; Region: HTH; cl00088 1127134011265 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1127134011266 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1127134011267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127134011268 ATP binding site [chemical binding]; other site 1127134011269 putative Mg++ binding site [ion binding]; other site 1127134011270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134011271 nucleotide binding region [chemical binding]; other site 1127134011272 ATP-binding site [chemical binding]; other site 1127134011273 TRCF domain; Region: TRCF; cl04088 1127134011274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134011275 Helix-turn-helix domains; Region: HTH; cl00088 1127134011276 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1127134011277 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1127134011278 Substrate binding site; other site 1127134011279 Mg++ binding site; other site 1127134011280 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1127134011281 active site 1127134011282 substrate binding site [chemical binding]; other site 1127134011283 CoA binding site [chemical binding]; other site 1127134011284 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1127134011285 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1127134011286 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127134011287 active site 1127134011288 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1127134011289 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1127134011290 probable methyltransferase; Region: TIGR03438 1127134011291 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1127134011292 TIGR03442 family protein; Region: TIGR03442 1127134011293 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1127134011294 putative dimer interface [polypeptide binding]; other site 1127134011295 putative active site [active] 1127134011296 TIGR03440 family protein; Region: unchr_TIGR03440 1127134011297 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 1127134011298 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1127134011299 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1127134011300 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134011301 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134011302 catalytic residue [active] 1127134011303 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134011304 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1127134011305 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011306 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1127134011307 putative active site [active] 1127134011308 catalytic residue [active] 1127134011309 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1127134011310 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1127134011311 5S rRNA interface [nucleotide binding]; other site 1127134011312 CTC domain interface [polypeptide binding]; other site 1127134011313 L16 interface [polypeptide binding]; other site 1127134011314 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1127134011315 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1127134011316 G1 box; other site 1127134011317 putative GEF interaction site [polypeptide binding]; other site 1127134011318 GTP/Mg2+ binding site [chemical binding]; other site 1127134011319 Switch I region; other site 1127134011320 G2 box; other site 1127134011321 G3 box; other site 1127134011322 Switch II region; other site 1127134011323 G4 box; other site 1127134011324 G5 box; other site 1127134011325 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1127134011326 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134011327 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 1127134011328 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1127134011329 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 1127134011330 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1127134011331 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134011332 Walker A/P-loop; other site 1127134011333 ATP binding site [chemical binding]; other site 1127134011334 ABC transporter signature motif; other site 1127134011335 Walker B; other site 1127134011336 D-loop; other site 1127134011337 H-loop/switch region; other site 1127134011338 ABC transporter; Region: ABC_tran_2; pfam12848 1127134011339 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1127134011340 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1127134011341 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1127134011342 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1127134011343 metal-binding site [ion binding] 1127134011344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134011345 Secretory lipase; Region: LIP; pfam03583 1127134011346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1127134011347 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1127134011348 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1127134011349 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1127134011350 G5 domain; Region: G5; pfam07501 1127134011351 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1127134011352 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1127134011353 active site 1127134011354 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1127134011355 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1127134011356 active site 1127134011357 HIGH motif; other site 1127134011358 KMSKS motif; other site 1127134011359 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1127134011360 tRNA binding surface [nucleotide binding]; other site 1127134011361 anticodon binding site; other site 1127134011362 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1127134011363 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1127134011364 tetramer interface [polypeptide binding]; other site 1127134011365 active site 1127134011366 Mg2+/Mn2+ binding site [ion binding]; other site 1127134011367 Predicted methyltransferases [General function prediction only]; Region: COG0313 1127134011368 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1127134011369 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1127134011370 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1127134011371 Predicted transcriptional regulators [Transcription]; Region: COG1725 1127134011372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134011373 DNA-binding site [nucleotide binding]; DNA binding site 1127134011374 Amidinotransferase; Region: Amidinotransf; cl12043 1127134011375 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1127134011376 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134011377 DNA binding residues [nucleotide binding] 1127134011378 short chain dehydrogenase; Provisional; Region: PRK07832 1127134011379 classical (c) SDRs; Region: SDR_c; cd05233 1127134011380 NAD(P) binding site [chemical binding]; other site 1127134011381 active site 1127134011382 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1127134011383 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 1127134011384 GAF domain; Region: GAF_2; pfam13185 1127134011385 GAF domain; Region: GAF; cl15785 1127134011386 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1127134011387 metal binding site [ion binding]; metal-binding site 1127134011388 active site 1127134011389 I-site; other site 1127134011390 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1127134011391 hypothetical protein; Provisional; Region: PRK07877 1127134011392 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1127134011393 ATP binding site [chemical binding]; other site 1127134011394 substrate interface [chemical binding]; other site 1127134011395 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1127134011396 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1127134011397 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1127134011398 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1127134011399 Fe-S cluster binding site [ion binding]; other site 1127134011400 DNA binding site [nucleotide binding] 1127134011401 active site 1127134011402 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1127134011403 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1127134011404 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1127134011405 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1127134011406 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1127134011407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127134011408 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134011409 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134011410 DNA binding residues [nucleotide binding] 1127134011411 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134011412 DNA binding residues [nucleotide binding] 1127134011413 dimerization interface [polypeptide binding]; other site 1127134011414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134011415 DNA binding residues [nucleotide binding] 1127134011416 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134011417 DNA binding residues [nucleotide binding] 1127134011418 dimerization interface [polypeptide binding]; other site 1127134011419 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1127134011420 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1127134011421 Zn binding site [ion binding]; other site 1127134011422 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134011423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134011424 DNA binding residues [nucleotide binding] 1127134011425 dimerization interface [polypeptide binding]; other site 1127134011426 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1127134011427 putative acyl-acceptor binding pocket; other site 1127134011428 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1127134011429 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1127134011430 putative transposase OrfB; Reviewed; Region: PHA02517 1127134011431 HTH-like domain; Region: HTH_21; pfam13276 1127134011432 Integrase core domain; Region: rve; cl01316 1127134011433 Integrase core domain; Region: rve_3; cl15866 1127134011434 Helix-turn-helix domains; Region: HTH; cl00088 1127134011435 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1127134011436 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127134011437 active site 1127134011438 catalytic tetrad [active] 1127134011439 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1127134011440 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1127134011441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134011442 S-adenosylmethionine binding site [chemical binding]; other site 1127134011443 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134011444 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1127134011445 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1127134011446 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1127134011447 dimer interface [polypeptide binding]; other site 1127134011448 putative functional site; other site 1127134011449 putative MPT binding site; other site 1127134011450 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1127134011451 active site 1127134011452 tetramer interface; other site 1127134011453 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 1127134011454 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1127134011455 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1127134011456 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1127134011457 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 1127134011458 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1127134011459 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1127134011460 MspA; Region: MspA; pfam09203 1127134011461 MspA; Region: MspA; pfam09203 1127134011462 MspA; Region: MspA; pfam09203 1127134011463 MspA; Region: MspA; pfam09203 1127134011464 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1127134011465 MPT binding site; other site 1127134011466 trimer interface [polypeptide binding]; other site 1127134011467 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1127134011468 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1127134011469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127134011470 dimerization interface [polypeptide binding]; other site 1127134011471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127134011472 dimer interface [polypeptide binding]; other site 1127134011473 phosphorylation site [posttranslational modification] 1127134011474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134011475 ATP binding site [chemical binding]; other site 1127134011476 Mg2+ binding site [ion binding]; other site 1127134011477 G-X-G motif; other site 1127134011478 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127134011479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134011480 active site 1127134011481 phosphorylation site [posttranslational modification] 1127134011482 intermolecular recognition site; other site 1127134011483 dimerization interface [polypeptide binding]; other site 1127134011484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127134011485 DNA binding site [nucleotide binding] 1127134011486 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127134011487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134011488 ATP binding site [chemical binding]; other site 1127134011489 Mg2+ binding site [ion binding]; other site 1127134011490 G-X-G motif; other site 1127134011491 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1127134011492 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1127134011493 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1127134011494 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1127134011495 G1 box; other site 1127134011496 GTP/Mg2+ binding site [chemical binding]; other site 1127134011497 G2 box; other site 1127134011498 Switch I region; other site 1127134011499 G3 box; other site 1127134011500 Switch II region; other site 1127134011501 G4 box; other site 1127134011502 G5 box; other site 1127134011503 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1127134011504 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1127134011505 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1127134011506 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 1127134011507 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1127134011508 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 1127134011509 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1127134011510 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1127134011511 purine monophosphate binding site [chemical binding]; other site 1127134011512 dimer interface [polypeptide binding]; other site 1127134011513 putative catalytic residues [active] 1127134011514 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1127134011515 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1127134011516 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1127134011517 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1127134011518 active site 1127134011519 substrate binding site [chemical binding]; other site 1127134011520 cosubstrate binding site; other site 1127134011521 catalytic site [active] 1127134011522 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1127134011523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134011524 CoA-ligase; Region: Ligase_CoA; cl02894 1127134011525 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1127134011526 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134011527 CoA-ligase; Region: Ligase_CoA; cl02894 1127134011528 Peptidase family M23; Region: Peptidase_M23; pfam01551 1127134011529 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134011530 hydrophobic ligand binding site; other site 1127134011531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134011532 TIGR01777 family protein; Region: yfcH 1127134011533 NAD(P) binding site [chemical binding]; other site 1127134011534 active site 1127134011535 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1127134011536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134011537 Family description; Region: UvrD_C_2; cl15862 1127134011538 Chorismate mutase type II; Region: CM_2; cl00693 1127134011539 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134011540 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1127134011541 tetramerization interface [polypeptide binding]; other site 1127134011542 NAD(P) binding site [chemical binding]; other site 1127134011543 catalytic residues [active] 1127134011544 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1127134011545 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1127134011546 active site 1127134011547 dimer interface [polypeptide binding]; other site 1127134011548 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1127134011549 dimer interface [polypeptide binding]; other site 1127134011550 active site 1127134011551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134011552 putative substrate translocation pore; other site 1127134011553 Helix-turn-helix domains; Region: HTH; cl00088 1127134011554 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1127134011555 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134011556 active site 1127134011557 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1127134011558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134011559 active site 1127134011560 Ion channel; Region: Ion_trans_2; cl11596 1127134011561 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134011562 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1127134011563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134011564 DNA-binding site [nucleotide binding]; DNA binding site 1127134011565 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127134011566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134011567 homodimer interface [polypeptide binding]; other site 1127134011568 catalytic residue [active] 1127134011569 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1127134011570 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127134011571 active site 1127134011572 catalytic tetrad [active] 1127134011573 Helix-turn-helix domains; Region: HTH; cl00088 1127134011574 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1127134011575 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1127134011576 putative DNA binding site [nucleotide binding]; other site 1127134011577 catalytic residue [active] 1127134011578 putative H2TH interface [polypeptide binding]; other site 1127134011579 putative catalytic residues [active] 1127134011580 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1127134011581 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1127134011582 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1127134011583 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134011584 substrate binding pocket [chemical binding]; other site 1127134011585 catalytic triad [active] 1127134011586 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1127134011587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134011588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134011589 DNA binding residues [nucleotide binding] 1127134011590 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1127134011591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134011592 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1127134011593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134011594 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1127134011595 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1127134011596 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1127134011597 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1127134011598 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1127134011599 dimerization interface [polypeptide binding]; other site 1127134011600 active site 1127134011601 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1127134011602 folate binding site [chemical binding]; other site 1127134011603 NADP+ binding site [chemical binding]; other site 1127134011604 Cupin domain; Region: Cupin_2; cl09118 1127134011605 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1127134011606 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1127134011607 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 1127134011608 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1127134011609 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134011610 putative metal binding site [ion binding]; other site 1127134011611 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 1127134011612 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134011613 putative metal binding site [ion binding]; other site 1127134011614 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1127134011615 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134011616 Predicted transcriptional regulator [Transcription]; Region: COG2378 1127134011617 Helix-turn-helix domains; Region: HTH; cl00088 1127134011618 WYL domain; Region: WYL; cl14852 1127134011619 Helix-turn-helix domains; Region: HTH; cl00088 1127134011620 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1127134011621 putative catalytic residues [active] 1127134011622 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 1127134011623 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1127134011624 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1127134011625 putative active site [active] 1127134011626 peptide synthase; Provisional; Region: PRK12467 1127134011627 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011628 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011629 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011630 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011631 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011632 peptide synthase; Provisional; Region: PRK12467 1127134011633 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011634 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011635 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011636 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011637 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011638 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011639 peptide synthase; Provisional; Region: PRK12467 1127134011640 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011641 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011642 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011643 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011644 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011645 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011646 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1127134011647 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011648 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011649 peptide synthase; Provisional; Region: PRK12467 1127134011650 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011651 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011652 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011653 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011654 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011655 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011656 peptide synthase; Provisional; Region: PRK12467 1127134011657 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011658 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011659 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011660 peptide synthase; Provisional; Region: PRK12467 1127134011661 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011662 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011663 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011664 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011665 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011666 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011667 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1127134011668 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011669 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 1127134011670 large tegument protein UL36; Provisional; Region: PHA03247 1127134011671 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1127134011672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134011673 EspG family; Region: ESX-1_EspG; pfam14011 1127134011674 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1127134011675 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1127134011676 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127134011677 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1127134011678 Helix-turn-helix domains; Region: HTH; cl00088 1127134011679 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134011680 dimerization interface [polypeptide binding]; other site 1127134011681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134011682 metabolite-proton symporter; Region: 2A0106; TIGR00883 1127134011683 putative substrate translocation pore; other site 1127134011684 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1127134011685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134011686 NAD(P) binding site [chemical binding]; other site 1127134011687 active site 1127134011688 Helix-turn-helix domains; Region: HTH; cl00088 1127134011689 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1127134011690 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134011691 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134011692 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1127134011693 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127134011694 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134011695 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1127134011696 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1127134011697 carboxyltransferase (CT) interaction site; other site 1127134011698 biotinylation site [posttranslational modification]; other site 1127134011699 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134011700 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134011701 active site 1127134011702 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1127134011703 putative active site [active] 1127134011704 putative catalytic site [active] 1127134011705 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1127134011706 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1127134011707 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1127134011708 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011709 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134011710 Helix-turn-helix domains; Region: HTH; cl00088 1127134011711 Helix-turn-helix domains; Region: HTH; cl00088 1127134011712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134011713 Helix-turn-helix domains; Region: HTH; cl00088 1127134011714 Helix-turn-helix domains; Region: HTH; cl00088 1127134011715 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1127134011716 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134011717 mce related protein; Region: MCE; pfam02470 1127134011718 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134011719 mce related protein; Region: MCE; pfam02470 1127134011720 mce related protein; Region: MCE; pfam02470 1127134011721 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134011722 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134011723 mce related protein; Region: MCE; pfam02470 1127134011724 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134011725 mce related protein; Region: MCE; pfam02470 1127134011726 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134011727 mce related protein; Region: MCE; pfam02470 1127134011728 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1127134011729 Permease; Region: Permease; cl00510 1127134011730 Permease; Region: Permease; cl00510 1127134011731 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1127134011732 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1127134011733 putative [Fe4-S4] binding site [ion binding]; other site 1127134011734 putative molybdopterin cofactor binding site [chemical binding]; other site 1127134011735 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1127134011736 putative molybdopterin cofactor binding site; other site 1127134011737 MbtH-like protein; Region: MbtH; cl01279 1127134011738 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1127134011739 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011740 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011741 peptide synthase; Provisional; Region: PRK12467 1127134011742 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011743 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011744 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011745 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011746 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011747 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011748 peptide synthase; Provisional; Region: PRK12316 1127134011749 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011750 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011751 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011752 peptide synthase; Provisional; Region: PRK12467 1127134011753 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011754 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011755 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011756 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011757 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011758 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011759 peptide synthase; Provisional; Region: PRK12316 1127134011760 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011761 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011762 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011763 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011764 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1127134011765 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011766 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011767 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011768 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011769 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1127134011770 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011771 peptide synthase; Validated; Region: PRK05691 1127134011772 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011773 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011774 peptide synthase; Validated; Region: PRK05691 1127134011775 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011776 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011777 peptide synthase; Provisional; Region: PRK12467 1127134011778 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011779 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011780 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011781 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011782 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011783 peptide synthase; Provisional; Region: PRK12467 1127134011784 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011785 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134011786 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134011787 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127134011788 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1127134011789 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1127134011790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134011791 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1127134011792 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1127134011793 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1127134011794 active site 1127134011795 mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967 1127134011796 mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962 1127134011797 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127134011798 FeS/SAM binding site; other site 1127134011799 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1127134011800 mycofactocin precursor; Region: mycofactocin; TIGR03969 1127134011801 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1127134011802 Helix-turn-helix domains; Region: HTH; cl00088 1127134011803 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1127134011804 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1127134011805 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1127134011806 FAD binding pocket [chemical binding]; other site 1127134011807 FAD binding motif [chemical binding]; other site 1127134011808 phosphate binding motif [ion binding]; other site 1127134011809 beta-alpha-beta structure motif; other site 1127134011810 NAD(p) ribose binding residues [chemical binding]; other site 1127134011811 NAD binding pocket [chemical binding]; other site 1127134011812 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1127134011813 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1127134011814 catalytic loop [active] 1127134011815 iron binding site [ion binding]; other site 1127134011816 Secretory lipase; Region: LIP; pfam03583 1127134011817 Helix-turn-helix domains; Region: HTH; cl00088 1127134011818 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1127134011819 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134011820 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1127134011821 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1127134011822 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1127134011823 active site 1127134011824 elongation factor Tu; Reviewed; Region: PRK00049 1127134011825 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1127134011826 G1 box; other site 1127134011827 GEF interaction site [polypeptide binding]; other site 1127134011828 GTP/Mg2+ binding site [chemical binding]; other site 1127134011829 Switch I region; other site 1127134011830 G2 box; other site 1127134011831 G3 box; other site 1127134011832 Switch II region; other site 1127134011833 G4 box; other site 1127134011834 G5 box; other site 1127134011835 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1127134011836 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1127134011837 Antibiotic Binding Site [chemical binding]; other site 1127134011838 elongation factor G; Reviewed; Region: PRK00007 1127134011839 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1127134011840 G1 box; other site 1127134011841 putative GEF interaction site [polypeptide binding]; other site 1127134011842 GTP/Mg2+ binding site [chemical binding]; other site 1127134011843 Switch I region; other site 1127134011844 G2 box; other site 1127134011845 G3 box; other site 1127134011846 Switch II region; other site 1127134011847 G4 box; other site 1127134011848 G5 box; other site 1127134011849 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1127134011850 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1127134011851 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1127134011852 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 1127134011853 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1127134011854 S17 interaction site [polypeptide binding]; other site 1127134011855 S8 interaction site; other site 1127134011856 16S rRNA interaction site [nucleotide binding]; other site 1127134011857 streptomycin interaction site [chemical binding]; other site 1127134011858 23S rRNA interaction site [nucleotide binding]; other site 1127134011859 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1127134011860 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1127134011861 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1127134011862 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1127134011863 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1127134011864 dimer interface [polypeptide binding]; other site 1127134011865 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1127134011866 active site 1127134011867 Fe binding site [ion binding]; other site 1127134011868 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1127134011869 Helix-turn-helix domains; Region: HTH; cl00088 1127134011870 AsnC family; Region: AsnC_trans_reg; pfam01037 1127134011871 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1127134011872 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1127134011873 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1127134011874 NAD(P) binding site [chemical binding]; other site 1127134011875 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1127134011876 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1127134011877 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1127134011878 catalytic residue [active] 1127134011879 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1127134011880 active site 1127134011881 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134011882 active site 2 [active] 1127134011883 4Fe-4S binding domain; Region: Fer4; cl02805 1127134011884 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1127134011885 ferredoxin-NADP+ reductase; Region: PLN02852 1127134011886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134011887 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127134011888 catalytic core [active] 1127134011889 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134011890 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1127134011891 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1127134011892 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1127134011893 DNA binding residues [nucleotide binding] 1127134011894 putative dimer interface [polypeptide binding]; other site 1127134011895 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127134011896 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1127134011897 active site 1127134011898 catalytic tetrad [active] 1127134011899 Evidence 4 : Homologs of previously reported genes of unknown function 1127134011900 Evidence 4 : Homologs of previously reported genes of unknown function 1127134011901 Pirin-related protein [General function prediction only]; Region: COG1741 1127134011902 Cupin domain; Region: Cupin_2; cl09118 1127134011903 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1127134011904 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 1127134011905 putative hydrophobic ligand binding site [chemical binding]; other site 1127134011906 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134011907 dimerization interface [polypeptide binding]; other site 1127134011908 putative DNA binding site [nucleotide binding]; other site 1127134011909 putative Zn2+ binding site [ion binding]; other site 1127134011910 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1127134011911 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1127134011912 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 1127134011913 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1127134011914 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 1127134011915 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1127134011916 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1127134011917 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1127134011918 G-loop; other site 1127134011919 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1127134011920 DNA binding site [nucleotide binding] 1127134011921 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1127134011922 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1127134011923 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1127134011924 RPB12 interaction site [polypeptide binding]; other site 1127134011925 RPB1 interaction site [polypeptide binding]; other site 1127134011926 RPB10 interaction site [polypeptide binding]; other site 1127134011927 RPB11 interaction site [polypeptide binding]; other site 1127134011928 RPB3 interaction site [polypeptide binding]; other site 1127134011929 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134011930 mce related protein; Region: MCE; pfam02470 1127134011931 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134011932 mce related protein; Region: MCE; pfam02470 1127134011933 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1127134011934 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134011935 mce related protein; Region: MCE; pfam02470 1127134011936 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134011937 mce related protein; Region: MCE; pfam02470 1127134011938 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134011939 mce related protein; Region: MCE; pfam02470 1127134011940 mce related protein; Region: MCE; pfam02470 1127134011941 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1127134011942 Permease; Region: Permease; cl00510 1127134011943 Permease; Region: Permease; cl00510 1127134011944 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1127134011945 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 1127134011946 Walker A/P-loop; other site 1127134011947 ATP binding site [chemical binding]; other site 1127134011948 Q-loop/lid; other site 1127134011949 ABC transporter signature motif; other site 1127134011950 Walker B; other site 1127134011951 D-loop; other site 1127134011952 H-loop/switch region; other site 1127134011953 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1127134011954 core dimer interface [polypeptide binding]; other site 1127134011955 peripheral dimer interface [polypeptide binding]; other site 1127134011956 L10 interface [polypeptide binding]; other site 1127134011957 L11 interface [polypeptide binding]; other site 1127134011958 putative EF-Tu interaction site [polypeptide binding]; other site 1127134011959 putative EF-G interaction site [polypeptide binding]; other site 1127134011960 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1127134011961 23S rRNA interface [nucleotide binding]; other site 1127134011962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134011963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127134011964 putative substrate translocation pore; other site 1127134011965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134011966 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1127134011967 mRNA/rRNA interface [nucleotide binding]; other site 1127134011968 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1127134011969 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1127134011970 23S rRNA interface [nucleotide binding]; other site 1127134011971 L7/L12 interface [polypeptide binding]; other site 1127134011972 putative thiostrepton binding site; other site 1127134011973 L25 interface [polypeptide binding]; other site 1127134011974 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1127134011975 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1127134011976 putative homodimer interface [polypeptide binding]; other site 1127134011977 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 1127134011978 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1127134011979 active site 1127134011980 catalytic site [active] 1127134011981 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1127134011982 active site 1127134011983 catalytic site [active] 1127134011984 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 1127134011985 Protein of unknown function (DUF520); Region: DUF520; cl00723 1127134011986 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 1127134011987 Peptidase family M48; Region: Peptidase_M48; cl12018 1127134011988 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1127134011989 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1127134011990 substrate binding pocket [chemical binding]; other site 1127134011991 chain length determination region; other site 1127134011992 substrate-Mg2+ binding site; other site 1127134011993 catalytic residues [active] 1127134011994 aspartate-rich region 1; other site 1127134011995 active site lid residues [active] 1127134011996 aspartate-rich region 2; other site 1127134011997 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1127134011998 Helix-turn-helix domain; Region: HTH_18; pfam12833 1127134011999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134012000 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1127134012001 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134012002 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1127134012003 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1127134012004 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1127134012005 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134012006 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1127134012007 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1127134012008 Helix-turn-helix domains; Region: HTH; cl00088 1127134012009 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1127134012010 Predicted ATPase [General function prediction only]; Region: COG3903 1127134012011 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134012012 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134012013 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1127134012014 Walker A/P-loop; other site 1127134012015 ATP binding site [chemical binding]; other site 1127134012016 Q-loop/lid; other site 1127134012017 ABC transporter signature motif; other site 1127134012018 Walker B; other site 1127134012019 D-loop; other site 1127134012020 H-loop/switch region; other site 1127134012021 GtrA-like protein; Region: GtrA; cl00971 1127134012022 Helix-turn-helix domains; Region: HTH; cl00088 1127134012023 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1127134012024 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127134012025 active site 1127134012026 catalytic tetrad [active] 1127134012027 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1127134012028 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1127134012029 [4Fe-4S] binding site [ion binding]; other site 1127134012030 molybdopterin cofactor binding site; other site 1127134012031 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1127134012032 molybdopterin cofactor binding site; other site 1127134012033 sulfite reductase; Provisional; Region: PRK06214 1127134012034 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134012035 FAD binding domain; Region: FAD_binding_1; pfam00667 1127134012036 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1127134012037 FAD binding pocket [chemical binding]; other site 1127134012038 FAD binding motif [chemical binding]; other site 1127134012039 catalytic residues [active] 1127134012040 NAD binding pocket [chemical binding]; other site 1127134012041 phosphate binding motif [ion binding]; other site 1127134012042 beta-alpha-beta structure motif; other site 1127134012043 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1127134012044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134012045 S-adenosylmethionine binding site [chemical binding]; other site 1127134012046 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1127134012047 TIGR03086 family protein; Region: TIGR03086 1127134012048 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1127134012049 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1127134012050 dimer interface [polypeptide binding]; other site 1127134012051 tetramer interface [polypeptide binding]; other site 1127134012052 PYR/PP interface [polypeptide binding]; other site 1127134012053 TPP binding site [chemical binding]; other site 1127134012054 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1127134012055 TPP-binding site; other site 1127134012056 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1127134012057 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1127134012058 FAD binding pocket [chemical binding]; other site 1127134012059 FAD binding motif [chemical binding]; other site 1127134012060 phosphate binding motif [ion binding]; other site 1127134012061 NAD binding pocket [chemical binding]; other site 1127134012062 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134012063 CoenzymeA binding site [chemical binding]; other site 1127134012064 subunit interaction site [polypeptide binding]; other site 1127134012065 PHB binding site; other site 1127134012066 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1127134012067 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134012068 substrate binding site [chemical binding]; other site 1127134012069 oxyanion hole (OAH) forming residues; other site 1127134012070 trimer interface [polypeptide binding]; other site 1127134012071 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134012072 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1127134012073 active site 1127134012074 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1127134012075 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134012076 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134012077 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134012078 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1127134012079 Walker A/P-loop; other site 1127134012080 ATP binding site [chemical binding]; other site 1127134012081 Q-loop/lid; other site 1127134012082 ABC transporter signature motif; other site 1127134012083 Walker B; other site 1127134012084 D-loop; other site 1127134012085 H-loop/switch region; other site 1127134012086 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1127134012087 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134012088 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 1127134012089 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 1127134012090 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 1127134012091 putative hydrophobic ligand binding site [chemical binding]; other site 1127134012092 UbiA prenyltransferase family; Region: UbiA; cl00337 1127134012093 Membrane protein of unknown function; Region: DUF360; cl00850 1127134012094 Clp amino terminal domain; Region: Clp_N; pfam02861 1127134012095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134012096 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1127134012097 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134012098 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134012099 Helix-turn-helix domains; Region: HTH; cl00088 1127134012100 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1127134012101 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1127134012102 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134012103 catalytic residue [active] 1127134012104 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1127134012105 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1127134012106 DNA binding residues [nucleotide binding] 1127134012107 Secretory lipase; Region: LIP; pfam03583 1127134012108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134012109 Helix-turn-helix domains; Region: HTH; cl00088 1127134012110 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1127134012111 ResB-like family; Region: ResB; pfam05140 1127134012112 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1127134012113 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1127134012114 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1127134012115 catalytic residues [active] 1127134012116 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127134012117 catalytic core [active] 1127134012118 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1127134012119 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1127134012120 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127134012121 inhibitor-cofactor binding pocket; inhibition site 1127134012122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134012123 catalytic residue [active] 1127134012124 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1127134012125 dimer interface [polypeptide binding]; other site 1127134012126 active site 1127134012127 Schiff base residues; other site 1127134012128 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1127134012129 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1127134012130 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1127134012131 active site 1127134012132 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 1127134012133 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1127134012134 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 1127134012135 domain interfaces; other site 1127134012136 active site 1127134012137 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1127134012138 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1127134012139 tRNA; other site 1127134012140 putative tRNA binding site [nucleotide binding]; other site 1127134012141 putative NADP binding site [chemical binding]; other site 1127134012142 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1127134012143 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1127134012144 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1127134012145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012146 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1127134012147 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1127134012148 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1127134012149 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1127134012150 putative acyl-acceptor binding pocket; other site 1127134012151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012152 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1127134012153 NAD(P) binding site [chemical binding]; other site 1127134012154 active site 1127134012155 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134012156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012157 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1127134012158 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1127134012159 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134012160 CoenzymeA binding site [chemical binding]; other site 1127134012161 subunit interaction site [polypeptide binding]; other site 1127134012162 PHB binding site; other site 1127134012163 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134012164 active site 1 [active] 1127134012165 active site 2 [active] 1127134012166 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1127134012167 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1127134012168 DNA interaction; other site 1127134012169 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1127134012170 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 1127134012171 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127134012172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134012173 active site 1127134012174 phosphorylation site [posttranslational modification] 1127134012175 intermolecular recognition site; other site 1127134012176 dimerization interface [polypeptide binding]; other site 1127134012177 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127134012178 DNA binding site [nucleotide binding] 1127134012179 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1127134012180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127134012181 dimer interface [polypeptide binding]; other site 1127134012182 phosphorylation site [posttranslational modification] 1127134012183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134012184 ATP binding site [chemical binding]; other site 1127134012185 Mg2+ binding site [ion binding]; other site 1127134012186 G-X-G motif; other site 1127134012187 Predicted acyl esterases [General function prediction only]; Region: COG2936 1127134012188 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134012189 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1127134012190 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127134012191 catalytic core [active] 1127134012192 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127134012193 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1127134012194 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1127134012195 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1127134012196 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1127134012197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012198 NAD(P) binding site [chemical binding]; other site 1127134012199 active site 1127134012200 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134012201 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134012202 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134012203 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1127134012204 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1127134012205 putative ADP-binding pocket [chemical binding]; other site 1127134012206 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 1127134012207 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1127134012208 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1127134012209 FAD binding domain; Region: FAD_binding_4; pfam01565 1127134012210 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1127134012211 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1127134012212 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1127134012213 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134012214 non-specific DNA binding site [nucleotide binding]; other site 1127134012215 salt bridge; other site 1127134012216 sequence-specific DNA binding site [nucleotide binding]; other site 1127134012217 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134012218 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1127134012219 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1127134012220 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1127134012221 putative active site [active] 1127134012222 putative substrate binding site [chemical binding]; other site 1127134012223 putative cosubstrate binding site; other site 1127134012224 catalytic site [active] 1127134012225 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1127134012226 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134012227 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1127134012228 intersubunit interface [polypeptide binding]; other site 1127134012229 catalytic residue [active] 1127134012230 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1127134012231 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1127134012232 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134012233 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134012234 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1127134012235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134012236 non-specific DNA binding site [nucleotide binding]; other site 1127134012237 salt bridge; other site 1127134012238 sequence-specific DNA binding site [nucleotide binding]; other site 1127134012239 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1127134012240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134012241 Helix-turn-helix domains; Region: HTH; cl00088 1127134012242 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134012243 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134012244 active site 1127134012245 ATP binding site [chemical binding]; other site 1127134012246 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1127134012247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012248 NAD(P) binding pocket [chemical binding]; other site 1127134012249 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1127134012250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134012251 S-adenosylmethionine binding site [chemical binding]; other site 1127134012252 EspG family; Region: ESX-1_EspG; pfam14011 1127134012253 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1127134012254 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1127134012255 LGFP repeat; Region: LGFP; pfam08310 1127134012256 LGFP repeat; Region: LGFP; pfam08310 1127134012257 LGFP repeat; Region: LGFP; pfam08310 1127134012258 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1127134012259 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1127134012260 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1127134012261 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1127134012262 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1127134012263 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1127134012264 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1127134012265 protein binding site [polypeptide binding]; other site 1127134012266 Vitamin K epoxide reductase family; Region: VKOR; cl01729 1127134012267 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1127134012268 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134012269 substrate binding pocket [chemical binding]; other site 1127134012270 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134012271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012272 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134012273 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1127134012274 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1127134012275 putative NAD(P) binding site [chemical binding]; other site 1127134012276 putative substrate binding site [chemical binding]; other site 1127134012277 catalytic Zn binding site [ion binding]; other site 1127134012278 structural Zn binding site [ion binding]; other site 1127134012279 dimer interface [polypeptide binding]; other site 1127134012280 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1127134012281 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1127134012282 ATP binding site [chemical binding]; other site 1127134012283 Mg++ binding site [ion binding]; other site 1127134012284 motif III; other site 1127134012285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127134012286 nucleotide binding region [chemical binding]; other site 1127134012287 ATP-binding site [chemical binding]; other site 1127134012288 acyltransferase PapA5; Provisional; Region: PRK09294 1127134012289 acyltransferase PapA5; Provisional; Region: PRK09294 1127134012290 Helix-turn-helix domains; Region: HTH; cl00088 1127134012291 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1127134012292 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1127134012293 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1127134012294 THF binding site; other site 1127134012295 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1127134012296 substrate binding site [chemical binding]; other site 1127134012297 THF binding site; other site 1127134012298 zinc-binding site [ion binding]; other site 1127134012299 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1127134012300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012301 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1127134012302 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1127134012303 tetramer interface [polypeptide binding]; other site 1127134012304 active site 1127134012305 Mg2+/Mn2+ binding site [ion binding]; other site 1127134012306 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1127134012307 Secretory lipase; Region: LIP; pfam03583 1127134012308 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134012309 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1127134012310 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1127134012311 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1127134012312 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1127134012313 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1127134012314 putative substrate binding site [chemical binding]; other site 1127134012315 putative ATP binding site [chemical binding]; other site 1127134012316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134012317 non-specific DNA binding site [nucleotide binding]; other site 1127134012318 salt bridge; other site 1127134012319 sequence-specific DNA binding site [nucleotide binding]; other site 1127134012320 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1127134012321 Domain of unknown function (DUF955); Region: DUF955; cl01076 1127134012322 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1127134012323 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1127134012324 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1127134012325 active site 1127134012326 DNA binding site [nucleotide binding] 1127134012327 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1127134012328 DNA binding site [nucleotide binding] 1127134012329 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134012330 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1127134012331 Phosphate transporter family; Region: PHO4; cl00396 1127134012332 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1127134012333 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1127134012334 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1127134012335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127134012336 putative substrate translocation pore; other site 1127134012337 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1127134012338 Helix-turn-helix domains; Region: HTH; cl00088 1127134012339 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1127134012340 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1127134012341 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134012342 active site 1127134012343 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1127134012344 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1127134012345 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1127134012346 putative ligand binding site [chemical binding]; other site 1127134012347 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1127134012348 TM-ABC transporter signature motif; other site 1127134012349 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1127134012350 TM-ABC transporter signature motif; other site 1127134012351 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1127134012352 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 1127134012353 Walker A/P-loop; other site 1127134012354 ATP binding site [chemical binding]; other site 1127134012355 Q-loop/lid; other site 1127134012356 ABC transporter signature motif; other site 1127134012357 Walker B; other site 1127134012358 D-loop; other site 1127134012359 H-loop/switch region; other site 1127134012360 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1127134012361 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 1127134012362 Walker A/P-loop; other site 1127134012363 ATP binding site [chemical binding]; other site 1127134012364 Q-loop/lid; other site 1127134012365 ABC transporter signature motif; other site 1127134012366 Walker B; other site 1127134012367 D-loop; other site 1127134012368 H-loop/switch region; other site 1127134012369 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1127134012370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134012371 DNA-binding site [nucleotide binding]; DNA binding site 1127134012372 FCD domain; Region: FCD; cl11656 1127134012373 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134012374 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1127134012375 putative dimer interface [polypeptide binding]; other site 1127134012376 Helix-turn-helix domains; Region: HTH; cl00088 1127134012377 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1127134012378 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1127134012379 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1127134012380 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1127134012381 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1127134012382 active site 1127134012383 nucleophile elbow; other site 1127134012384 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1127134012385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134012386 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1127134012387 Helix-turn-helix domains; Region: HTH; cl00088 1127134012388 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127134012389 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134012390 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1127134012391 Helix-turn-helix domain; Region: HTH_18; pfam12833 1127134012392 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1127134012393 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1127134012394 NAD(P) binding site [chemical binding]; other site 1127134012395 substrate binding site [chemical binding]; other site 1127134012396 dimer interface [polypeptide binding]; other site 1127134012397 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127134012398 active site 1127134012399 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1127134012400 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134012401 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1127134012402 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127134012403 Helix-turn-helix domains; Region: HTH; cl00088 1127134012404 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1127134012405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134012406 active site 1127134012407 motif I; other site 1127134012408 motif II; other site 1127134012409 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1127134012410 active site residue [active] 1127134012411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134012412 Helix-turn-helix domains; Region: HTH; cl00088 1127134012413 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1127134012414 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134012415 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1127134012416 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1127134012417 ring oligomerisation interface [polypeptide binding]; other site 1127134012418 ATP/Mg binding site [chemical binding]; other site 1127134012419 stacking interactions; other site 1127134012420 hinge regions; other site 1127134012421 Clp amino terminal domain; Region: Clp_N; pfam02861 1127134012422 Clp amino terminal domain; Region: Clp_N; pfam02861 1127134012423 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1127134012424 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134012425 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1127134012426 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127134012427 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127134012428 DNA binding residues [nucleotide binding] 1127134012429 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1127134012430 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1127134012431 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1127134012432 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1127134012433 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1127134012434 dimer interface [polypeptide binding]; other site 1127134012435 active site 1127134012436 CoA binding pocket [chemical binding]; other site 1127134012437 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1127134012438 hydrophobic ligand binding site; other site 1127134012439 Response regulator receiver domain; Region: Response_reg; pfam00072 1127134012440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134012441 active site 1127134012442 phosphorylation site [posttranslational modification] 1127134012443 intermolecular recognition site; other site 1127134012444 dimerization interface [polypeptide binding]; other site 1127134012445 glycerol-3-phosphate dehydrogenase; Region: PLN02464 1127134012446 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1127134012447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134012449 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1127134012450 ligand binding site [chemical binding]; other site 1127134012451 flexible hinge region; other site 1127134012452 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1127134012453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127134012454 ATP binding site [chemical binding]; other site 1127134012455 Mg2+ binding site [ion binding]; other site 1127134012456 G-X-G motif; other site 1127134012457 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 1127134012458 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1127134012459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134012460 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1127134012461 Walker A motif; other site 1127134012462 ATP binding site [chemical binding]; other site 1127134012463 Walker B motif; other site 1127134012464 arginine finger; other site 1127134012465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134012466 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1127134012467 Walker A motif; other site 1127134012468 ATP binding site [chemical binding]; other site 1127134012469 Walker B motif; other site 1127134012470 arginine finger; other site 1127134012471 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1127134012472 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1127134012473 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1127134012474 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1127134012475 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1127134012476 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1127134012477 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1127134012478 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1127134012479 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1127134012480 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1127134012481 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1127134012482 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1127134012483 active site 1127134012484 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1127134012485 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1127134012486 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1127134012487 E-class dimer interface [polypeptide binding]; other site 1127134012488 P-class dimer interface [polypeptide binding]; other site 1127134012489 active site 1127134012490 Cu2+ binding site [ion binding]; other site 1127134012491 Zn2+ binding site [ion binding]; other site 1127134012492 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1127134012493 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1127134012494 active site 1127134012495 catalytic residues [active] 1127134012496 metal binding site [ion binding]; metal-binding site 1127134012497 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134012498 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1127134012499 putative catalytic site [active] 1127134012500 putative phosphate binding site [ion binding]; other site 1127134012501 active site 1127134012502 metal binding site A [ion binding]; metal-binding site 1127134012503 DNA binding site [nucleotide binding] 1127134012504 putative AP binding site [nucleotide binding]; other site 1127134012505 putative metal binding site B [ion binding]; other site 1127134012506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134012507 Helix-turn-helix domains; Region: HTH; cl00088 1127134012508 Cupin domain; Region: Cupin_2; cl09118 1127134012509 fumarylacetoacetase; Region: PLN02856 1127134012510 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1127134012511 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1127134012512 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1127134012513 dimer interface [polypeptide binding]; other site 1127134012514 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1127134012515 ThiC-associated domain; Region: ThiC-associated; pfam13667 1127134012516 ThiC family; Region: ThiC; cl08031 1127134012517 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134012518 CoenzymeA binding site [chemical binding]; other site 1127134012519 subunit interaction site [polypeptide binding]; other site 1127134012520 PHB binding site; other site 1127134012521 Permease; Region: Permease; cl00510 1127134012522 Permease; Region: Permease; cl00510 1127134012523 MoxR-like ATPases [General function prediction only]; Region: COG0714 1127134012524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134012525 Walker A motif; other site 1127134012526 ATP binding site [chemical binding]; other site 1127134012527 Walker B motif; other site 1127134012528 arginine finger; other site 1127134012529 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1127134012530 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1127134012531 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1127134012532 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1127134012533 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1127134012534 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127134012535 Helix-turn-helix domains; Region: HTH; cl00088 1127134012536 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1127134012537 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1127134012538 NAD(P) binding site [chemical binding]; other site 1127134012539 catalytic residues [active] 1127134012540 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134012541 active site 1127134012542 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1127134012543 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127134012544 inhibitor-cofactor binding pocket; inhibition site 1127134012545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134012546 catalytic residue [active] 1127134012547 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134012548 hydrophobic ligand binding site; other site 1127134012549 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 1127134012550 Flavin Reductases; Region: FlaRed; cl00801 1127134012551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012552 FAD dependent oxidoreductase; Region: DAO; pfam01266 1127134012553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012554 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1127134012555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134012556 Helix-turn-helix domains; Region: HTH; cl00088 1127134012557 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1127134012558 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 1127134012559 substrate binding pocket [chemical binding]; other site 1127134012560 membrane-bound complex binding site; other site 1127134012561 hinge residues; other site 1127134012562 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1127134012563 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1127134012564 Walker A/P-loop; other site 1127134012565 ATP binding site [chemical binding]; other site 1127134012566 Q-loop/lid; other site 1127134012567 ABC transporter signature motif; other site 1127134012568 Walker B; other site 1127134012569 D-loop; other site 1127134012570 H-loop/switch region; other site 1127134012571 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1127134012572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1127134012573 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1127134012574 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134012575 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1127134012576 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1127134012577 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134012578 Helix-turn-helix domains; Region: HTH; cl00088 1127134012579 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1127134012580 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1127134012581 NAD binding site [chemical binding]; other site 1127134012582 substrate binding site [chemical binding]; other site 1127134012583 putative active site [active] 1127134012584 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1127134012585 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1127134012586 dimer interface [polypeptide binding]; other site 1127134012587 active site 1127134012588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134012589 Helix-turn-helix domains; Region: HTH; cl00088 1127134012590 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134012591 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1127134012592 dimer interface [polypeptide binding]; other site 1127134012593 substrate binding site [chemical binding]; other site 1127134012594 ATP binding site [chemical binding]; other site 1127134012595 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134012596 Helix-turn-helix domains; Region: HTH; cl00088 1127134012597 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 1127134012598 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1127134012599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012600 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1127134012601 enoyl-CoA hydratase; Provisional; Region: PRK07827 1127134012602 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134012603 substrate binding site [chemical binding]; other site 1127134012604 oxyanion hole (OAH) forming residues; other site 1127134012605 trimer interface [polypeptide binding]; other site 1127134012606 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1127134012607 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134012608 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1127134012609 active site 1127134012610 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1127134012611 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127134012612 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1127134012613 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1127134012614 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1127134012615 carboxyltransferase (CT) interaction site; other site 1127134012616 biotinylation site [posttranslational modification]; other site 1127134012617 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1127134012618 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134012619 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1127134012620 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134012621 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134012622 active site 1127134012623 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1127134012624 cyclase homology domain; Region: CHD; cd07302 1127134012625 nucleotidyl binding site; other site 1127134012626 metal binding site [ion binding]; metal-binding site 1127134012627 dimer interface [polypeptide binding]; other site 1127134012628 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1127134012629 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127134012630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134012631 Walker A/P-loop; other site 1127134012632 ATP binding site [chemical binding]; other site 1127134012633 Q-loop/lid; other site 1127134012634 ABC transporter signature motif; other site 1127134012635 Walker B; other site 1127134012636 D-loop; other site 1127134012637 H-loop/switch region; other site 1127134012638 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1127134012639 ThiS interaction site; other site 1127134012640 putative active site [active] 1127134012641 tetramer interface [polypeptide binding]; other site 1127134012642 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1127134012643 thiS-thiF/thiG interaction site; other site 1127134012644 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1127134012645 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1127134012646 thiamine phosphate binding site [chemical binding]; other site 1127134012647 active site 1127134012648 pyrophosphate binding site [ion binding]; other site 1127134012649 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1127134012650 nudix motif; other site 1127134012651 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1127134012652 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1127134012653 substrate binding pocket [chemical binding]; other site 1127134012654 membrane-bound complex binding site; other site 1127134012655 hinge residues; other site 1127134012656 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1127134012657 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127134012658 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127134012659 active site 1127134012660 ATP binding site [chemical binding]; other site 1127134012661 substrate binding site [chemical binding]; other site 1127134012662 activation loop (A-loop); other site 1127134012663 acetate kinase; Region: ackA; TIGR00016 1127134012664 Acetokinase family; Region: Acetate_kinase; cl01029 1127134012665 phosphate acetyltransferase; Reviewed; Region: PRK05632 1127134012666 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134012667 DRTGG domain; Region: DRTGG; cl12147 1127134012668 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1127134012669 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134012670 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1127134012671 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134012672 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1127134012673 UMP phosphatase; Provisional; Region: PRK10444 1127134012674 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134012675 active site 1127134012676 motif I; other site 1127134012677 motif II; other site 1127134012678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127134012679 motif II; other site 1127134012680 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1127134012681 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134012682 PHB binding site; other site 1127134012683 CoenzymeA binding site [chemical binding]; other site 1127134012684 subunit interaction site [polypeptide binding]; other site 1127134012685 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127134012686 Helix-turn-helix domains; Region: HTH; cl00088 1127134012687 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1127134012688 conserved cys residue [active] 1127134012689 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1127134012690 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134012691 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127134012692 catalytic residue [active] 1127134012693 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1127134012694 active site residue [active] 1127134012695 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1127134012696 ferredoxin-NADP+ reductase; Region: PLN02852 1127134012697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012698 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1127134012699 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127134012700 active site 1127134012701 NlpC/P60 family; Region: NLPC_P60; cl11438 1127134012702 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1127134012703 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1127134012704 oligomeric interface; other site 1127134012705 putative active site [active] 1127134012706 homodimer interface [polypeptide binding]; other site 1127134012707 TIGR03086 family protein; Region: TIGR03086 1127134012708 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1127134012709 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134012710 Protein of unknown function (DUF456); Region: DUF456; cl01069 1127134012711 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1127134012712 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1127134012713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134012714 DNA-binding site [nucleotide binding]; DNA binding site 1127134012715 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127134012716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134012717 homodimer interface [polypeptide binding]; other site 1127134012718 catalytic residue [active] 1127134012719 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1127134012720 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1127134012721 DNA binding site [nucleotide binding] 1127134012722 active site 1127134012723 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134012724 Walker A motif; other site 1127134012725 ATP binding site [chemical binding]; other site 1127134012726 Predicted ATPase [General function prediction only]; Region: COG3899 1127134012727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134012728 DNA binding residues [nucleotide binding] 1127134012729 dimerization interface [polypeptide binding]; other site 1127134012730 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1127134012731 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1127134012732 GDP-binding site [chemical binding]; other site 1127134012733 ACT binding site; other site 1127134012734 IMP binding site; other site 1127134012735 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1127134012736 active site 1127134012737 putative substrate binding region [chemical binding]; other site 1127134012738 Predicted membrane protein [Function unknown]; Region: COG4129 1127134012739 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1127134012740 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1127134012741 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134012742 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1127134012743 active site 1127134012744 catalytic site [active] 1127134012745 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134012746 active site 2 [active] 1127134012747 active site 1 [active] 1127134012748 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1127134012749 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1127134012750 Helix-turn-helix domains; Region: HTH; cl00088 1127134012751 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1127134012752 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1127134012753 phosphopeptide binding site; other site 1127134012754 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1127134012755 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1127134012756 active site 1127134012757 intersubunit interface [polypeptide binding]; other site 1127134012758 zinc binding site [ion binding]; other site 1127134012759 Na+ binding site [ion binding]; other site 1127134012760 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1127134012761 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1127134012762 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134012763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134012764 active site 1127134012765 phosphorylation site [posttranslational modification] 1127134012766 intermolecular recognition site; other site 1127134012767 dimerization interface [polypeptide binding]; other site 1127134012768 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134012769 DNA binding residues [nucleotide binding] 1127134012770 dimerization interface [polypeptide binding]; other site 1127134012771 Putative sensor; Region: Sensor; pfam13796 1127134012772 Histidine kinase; Region: HisKA_3; pfam07730 1127134012773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1127134012774 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1127134012775 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1127134012776 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1127134012777 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134012778 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 1127134012779 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1127134012780 putative active site [active] 1127134012781 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134012782 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1127134012783 YhhN-like protein; Region: YhhN; cl01505 1127134012784 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1127134012785 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1127134012786 dimer interface [polypeptide binding]; other site 1127134012787 active site 1127134012788 CoA binding pocket [chemical binding]; other site 1127134012789 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127134012790 active site 1127134012791 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1127134012792 Clp amino terminal domain; Region: Clp_N; pfam02861 1127134012793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134012794 Walker A motif; other site 1127134012795 ATP binding site [chemical binding]; other site 1127134012796 Walker B motif; other site 1127134012797 arginine finger; other site 1127134012798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127134012799 Walker A motif; other site 1127134012800 ATP binding site [chemical binding]; other site 1127134012801 Walker B motif; other site 1127134012802 arginine finger; other site 1127134012803 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1127134012804 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1127134012805 heme-binding site [chemical binding]; other site 1127134012806 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1127134012807 FAD binding pocket [chemical binding]; other site 1127134012808 FAD binding motif [chemical binding]; other site 1127134012809 phosphate binding motif [ion binding]; other site 1127134012810 beta-alpha-beta structure motif; other site 1127134012811 NAD binding pocket [chemical binding]; other site 1127134012812 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1127134012813 FAD binding pocket [chemical binding]; other site 1127134012814 FAD binding motif [chemical binding]; other site 1127134012815 phosphate binding motif [ion binding]; other site 1127134012816 beta-alpha-beta structure motif; other site 1127134012817 NAD binding pocket [chemical binding]; other site 1127134012818 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1127134012819 heme-binding site [chemical binding]; other site 1127134012820 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1127134012821 FAD binding pocket [chemical binding]; other site 1127134012822 FAD binding motif [chemical binding]; other site 1127134012823 phosphate binding motif [ion binding]; other site 1127134012824 beta-alpha-beta structure motif; other site 1127134012825 NAD binding pocket [chemical binding]; other site 1127134012826 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127134012827 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134012828 DNA binding residues [nucleotide binding] 1127134012829 chaperone protein DnaJ; Provisional; Region: PRK14279 1127134012830 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1127134012831 HSP70 interaction site [polypeptide binding]; other site 1127134012832 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1127134012833 Zn binding sites [ion binding]; other site 1127134012834 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1127134012835 dimer interface [polypeptide binding]; other site 1127134012836 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1127134012837 dimer interface [polypeptide binding]; other site 1127134012838 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1127134012839 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1127134012840 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1127134012841 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1127134012842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134012843 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1127134012844 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1127134012845 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134012846 G1 box; other site 1127134012847 GTP/Mg2+ binding site [chemical binding]; other site 1127134012848 G2 box; other site 1127134012849 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134012850 Dynamin family; Region: Dynamin_N; pfam00350 1127134012851 G1 box; other site 1127134012852 GTP/Mg2+ binding site [chemical binding]; other site 1127134012853 G2 box; other site 1127134012854 Switch I region; other site 1127134012855 G3 box; other site 1127134012856 Switch II region; other site 1127134012857 G4 box; other site 1127134012858 G5 box; other site 1127134012859 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1127134012860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134012861 DNA binding residues [nucleotide binding] 1127134012862 dimerization interface [polypeptide binding]; other site 1127134012863 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1127134012864 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134012865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134012866 DNA binding residues [nucleotide binding] 1127134012867 dimerization interface [polypeptide binding]; other site 1127134012868 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1127134012869 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1127134012870 4Fe-4S binding domain; Region: Fer4; cl02805 1127134012871 4Fe-4S binding domain; Region: Fer4; cl02805 1127134012872 Cysteine-rich domain; Region: CCG; pfam02754 1127134012873 Cysteine-rich domain; Region: CCG; pfam02754 1127134012874 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1127134012875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012876 NAD(P) binding site [chemical binding]; other site 1127134012877 active site 1127134012878 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1127134012879 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134012880 active site 1127134012881 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1127134012882 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1127134012883 active site 1127134012884 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1127134012885 putative active site [active] 1127134012886 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1127134012887 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1127134012888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012889 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1127134012890 YibE/F-like protein; Region: YibE_F; cl02259 1127134012891 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1127134012892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127134012893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134012894 homodimer interface [polypeptide binding]; other site 1127134012895 catalytic residue [active] 1127134012896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134012897 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1127134012898 trimer interface [polypeptide binding]; other site 1127134012899 active site 1127134012900 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1127134012901 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127134012902 amidase; Provisional; Region: PRK07869 1127134012903 Amidase; Region: Amidase; cl11426 1127134012904 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134012905 Predicted membrane protein [Function unknown]; Region: COG4270 1127134012906 Flavin Reductases; Region: FlaRed; cl00801 1127134012907 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1127134012908 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1127134012909 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134012910 active site 1127134012911 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1127134012912 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1127134012913 active site 1127134012914 dimer interface [polypeptide binding]; other site 1127134012915 non-prolyl cis peptide bond; other site 1127134012916 insertion regions; other site 1127134012917 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134012918 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 1127134012919 GAF domain; Region: GAF; cl15785 1127134012920 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1127134012921 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1127134012922 active site 1127134012923 non-prolyl cis peptide bond; other site 1127134012924 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1127134012925 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134012926 active site 1127134012927 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1127134012928 PemK-like protein; Region: PemK; cl00995 1127134012929 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134012930 enoyl-CoA hydratase; Provisional; Region: PRK08252 1127134012931 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134012932 substrate binding site [chemical binding]; other site 1127134012933 oxyanion hole (OAH) forming residues; other site 1127134012934 trimer interface [polypeptide binding]; other site 1127134012935 enoyl-CoA hydratase; Provisional; Region: PRK07509 1127134012936 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127134012937 substrate binding site [chemical binding]; other site 1127134012938 oxyanion hole (OAH) forming residues; other site 1127134012939 trimer interface [polypeptide binding]; other site 1127134012940 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1127134012941 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1127134012942 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1127134012943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134012944 S-adenosylmethionine binding site [chemical binding]; other site 1127134012945 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1127134012946 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1127134012947 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1127134012948 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1127134012949 FAD binding site [chemical binding]; other site 1127134012950 substrate binding site [chemical binding]; other site 1127134012951 catalytic residues [active] 1127134012952 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1127134012953 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1127134012954 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134012955 non-specific DNA binding site [nucleotide binding]; other site 1127134012956 salt bridge; other site 1127134012957 sequence-specific DNA binding site [nucleotide binding]; other site 1127134012958 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1127134012959 VanW like protein; Region: VanW; pfam04294 1127134012960 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1127134012961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012962 Secretory lipase; Region: LIP; pfam03583 1127134012963 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134012964 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1127134012965 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1127134012966 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1127134012967 dimer interface [polypeptide binding]; other site 1127134012968 active site 1127134012969 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1127134012970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134012971 NAD(P) binding site [chemical binding]; other site 1127134012972 active site 1127134012973 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134012974 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1127134012975 active site 2 [active] 1127134012976 active site 1 [active] 1127134012977 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127134012978 Helix-turn-helix domains; Region: HTH; cl00088 1127134012979 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1127134012980 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1127134012981 Ligand Binding Site [chemical binding]; other site 1127134012982 isochorismate synthase DhbC; Validated; Region: PRK06923 1127134012983 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1127134012984 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1127134012985 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1127134012986 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1127134012987 OpgC protein; Region: OpgC_C; cl00792 1127134012988 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1127134012989 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1127134012990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1127134012991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134012992 S-adenosylmethionine binding site [chemical binding]; other site 1127134012993 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1127134012994 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127134012995 NAD binding site [chemical binding]; other site 1127134012996 catalytic residues [active] 1127134012997 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1127134012998 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 1127134012999 active site 1127134013000 substrate-binding site [chemical binding]; other site 1127134013001 metal-binding site [ion binding] 1127134013002 GTP binding site [chemical binding]; other site 1127134013003 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134013004 G3 box; other site 1127134013005 Switch II region; other site 1127134013006 G4 box; other site 1127134013007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134013008 NAD(P) binding site [chemical binding]; other site 1127134013009 active site 1127134013010 Secretory lipase; Region: LIP; pfam03583 1127134013011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134013012 LabA_like proteins; Region: LabA_like; cd06167 1127134013013 putative metal binding site [ion binding]; other site 1127134013014 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127134013015 Protein export membrane protein; Region: SecD_SecF; cl14618 1127134013016 Prion/Doppel alpha-helical domain; Region: Prion; cl02493 1127134013017 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1127134013018 putative active site [active] 1127134013019 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1127134013020 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1127134013021 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127134013022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127134013023 active site 1127134013024 phosphorylation site [posttranslational modification] 1127134013025 intermolecular recognition site; other site 1127134013026 dimerization interface [polypeptide binding]; other site 1127134013027 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127134013028 DNA binding residues [nucleotide binding] 1127134013029 dimerization interface [polypeptide binding]; other site 1127134013030 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127134013031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1127134013032 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1127134013033 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1127134013034 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1127134013035 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127134013036 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127134013037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134013038 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1127134013039 NAD(P) binding site [chemical binding]; other site 1127134013040 active site 1127134013041 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127134013042 dimerization interface [polypeptide binding]; other site 1127134013043 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1127134013044 cyclase homology domain; Region: CHD; cd07302 1127134013045 nucleotidyl binding site; other site 1127134013046 metal binding site [ion binding]; metal-binding site 1127134013047 dimer interface [polypeptide binding]; other site 1127134013048 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1127134013049 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1127134013050 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1127134013051 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1127134013052 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1127134013053 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134013054 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1127134013055 trimer interface [polypeptide binding]; other site 1127134013056 active site 1127134013057 dimer interface [polypeptide binding]; other site 1127134013058 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134013059 Predicted membrane protein [Function unknown]; Region: COG2860 1127134013060 UPF0126 domain; Region: UPF0126; pfam03458 1127134013061 UPF0126 domain; Region: UPF0126; pfam03458 1127134013062 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134013063 dimerization interface [polypeptide binding]; other site 1127134013064 putative DNA binding site [nucleotide binding]; other site 1127134013065 putative Zn2+ binding site [ion binding]; other site 1127134013066 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 1127134013067 putative hydrophobic ligand binding site [chemical binding]; other site 1127134013068 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127134013069 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134013070 Walker A/P-loop; other site 1127134013071 ATP binding site [chemical binding]; other site 1127134013072 Q-loop/lid; other site 1127134013073 ABC transporter signature motif; other site 1127134013074 Walker B; other site 1127134013075 D-loop; other site 1127134013076 H-loop/switch region; other site 1127134013077 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1127134013078 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134013079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134013080 salt bridge; other site 1127134013081 non-specific DNA binding site [nucleotide binding]; other site 1127134013082 sequence-specific DNA binding site [nucleotide binding]; other site 1127134013083 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1127134013084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134013085 Helix-turn-helix domains; Region: HTH; cl00088 1127134013086 Glycerate kinase family; Region: Gly_kinase; cl00841 1127134013087 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1127134013088 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1127134013089 putative acyl-acceptor binding pocket; other site 1127134013090 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 1127134013091 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1127134013092 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1127134013093 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134013094 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1127134013095 Walker A/P-loop; other site 1127134013096 ATP binding site [chemical binding]; other site 1127134013097 Q-loop/lid; other site 1127134013098 ABC transporter signature motif; other site 1127134013099 Walker B; other site 1127134013100 D-loop; other site 1127134013101 H-loop/switch region; other site 1127134013102 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1127134013103 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1127134013104 PYR/PP interface [polypeptide binding]; other site 1127134013105 dimer interface [polypeptide binding]; other site 1127134013106 TPP binding site [chemical binding]; other site 1127134013107 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1127134013108 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1127134013109 TPP-binding site [chemical binding]; other site 1127134013110 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134013111 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1127134013112 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1127134013113 active site 1127134013114 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127134013115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127134013116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127134013117 homodimer interface [polypeptide binding]; other site 1127134013118 catalytic residue [active] 1127134013119 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1127134013120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134013121 NAD(P) binding site [chemical binding]; other site 1127134013122 active site 1127134013123 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134013124 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134013125 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1127134013126 EspG family; Region: ESX-1_EspG; pfam14011 1127134013127 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1127134013128 RHS Repeat; Region: RHS_repeat; cl11982 1127134013129 RHS Repeat; Region: RHS_repeat; cl11982 1127134013130 RHS Repeat; Region: RHS_repeat; cl11982 1127134013131 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1127134013132 RHS Repeat; Region: RHS_repeat; cl11982 1127134013133 RHS Repeat; Region: RHS_repeat; cl11982 1127134013134 RHS Repeat; Region: RHS_repeat; cl11982 1127134013135 RHS Repeat; Region: RHS_repeat; cl11982 1127134013136 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1127134013137 Protein of unknown function (DUF692); Region: DUF692; cl01263 1127134013138 TIGR04222 domain; Region: near_uncomplex 1127134013139 TIGR04222 domain; Region: near_uncomplex 1127134013140 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1127134013141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134013142 NAD(P) binding site [chemical binding]; other site 1127134013143 active site 1127134013144 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1127134013145 NodB motif; other site 1127134013146 active site 1127134013147 catalytic site [active] 1127134013148 metal binding site [ion binding]; metal-binding site 1127134013149 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1127134013150 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1127134013151 active site 1127134013152 HIGH motif; other site 1127134013153 nucleotide binding site [chemical binding]; other site 1127134013154 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1127134013155 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1127134013156 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1127134013157 active site 1127134013158 KMSKS motif; other site 1127134013159 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1127134013160 tRNA binding surface [nucleotide binding]; other site 1127134013161 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1127134013162 active site 1127134013163 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1127134013164 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1127134013165 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134013166 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134013167 Domain of unknown function (DUF385); Region: DUF385; cl04387 1127134013168 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1127134013169 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1127134013170 Walker A/P-loop; other site 1127134013171 ATP binding site [chemical binding]; other site 1127134013172 Q-loop/lid; other site 1127134013173 ABC transporter signature motif; other site 1127134013174 Walker B; other site 1127134013175 D-loop; other site 1127134013176 H-loop/switch region; other site 1127134013177 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1127134013178 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1127134013179 substrate binding pocket [chemical binding]; other site 1127134013180 membrane-bound complex binding site; other site 1127134013181 hinge residues; other site 1127134013182 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1127134013183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134013184 dimer interface [polypeptide binding]; other site 1127134013185 conserved gate region; other site 1127134013186 putative PBP binding loops; other site 1127134013187 ABC-ATPase subunit interface; other site 1127134013188 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1127134013189 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127134013190 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1127134013191 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1127134013192 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1127134013193 Walker A/P-loop; other site 1127134013194 ATP binding site [chemical binding]; other site 1127134013195 Q-loop/lid; other site 1127134013196 ABC transporter signature motif; other site 1127134013197 Walker B; other site 1127134013198 D-loop; other site 1127134013199 H-loop/switch region; other site 1127134013200 TOBE domain; Region: TOBE_2; cl01440 1127134013201 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1127134013202 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1127134013203 active site 1127134013204 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1127134013205 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127134013206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134013207 dimer interface [polypeptide binding]; other site 1127134013208 conserved gate region; other site 1127134013209 putative PBP binding loops; other site 1127134013210 ABC-ATPase subunit interface; other site 1127134013211 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1127134013212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127134013213 dimer interface [polypeptide binding]; other site 1127134013214 conserved gate region; other site 1127134013215 putative PBP binding loops; other site 1127134013216 ABC-ATPase subunit interface; other site 1127134013217 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1127134013218 Transglycosylase; Region: Transgly; cl07896 1127134013219 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134013220 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1127134013221 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1127134013222 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1127134013223 Helix-turn-helix domains; Region: HTH; cl00088 1127134013224 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1127134013225 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1127134013226 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1127134013227 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1127134013228 Transglycosylase; Region: Transgly; cl07896 1127134013229 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134013230 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1127134013231 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1127134013232 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1127134013233 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134013234 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1127134013235 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134013236 putative metal binding site [ion binding]; other site 1127134013237 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1127134013238 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134013239 putative metal binding site [ion binding]; other site 1127134013240 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 1127134013241 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 1127134013242 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 1127134013243 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1127134013244 FMN binding site [chemical binding]; other site 1127134013245 active site 1127134013246 substrate binding site [chemical binding]; other site 1127134013247 catalytic residue [active] 1127134013248 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1127134013249 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127134013250 DNA binding residues [nucleotide binding] 1127134013251 putative dimer interface [polypeptide binding]; other site 1127134013252 Helix-turn-helix domains; Region: HTH; cl00088 1127134013253 WYL domain; Region: WYL; cl14852 1127134013254 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1127134013255 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127134013256 active site 1127134013257 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 1127134013258 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 1127134013259 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1127134013260 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1127134013261 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134013262 putative metal binding site [ion binding]; other site 1127134013263 Integral membrane protein TerC family; Region: TerC; cl10468 1127134013264 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 1127134013265 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127134013266 putative metal binding site [ion binding]; other site 1127134013267 Domain of unknown function (DUF389); Region: DUF389; cl00781 1127134013268 Secretory lipase; Region: LIP; pfam03583 1127134013269 Cutinase; Region: Cutinase; pfam01083 1127134013270 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1127134013271 replicative DNA helicase; Region: DnaB; TIGR00665 1127134013272 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1127134013273 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1127134013274 Walker A motif; other site 1127134013275 ATP binding site [chemical binding]; other site 1127134013276 Walker B motif; other site 1127134013277 DNA binding loops [nucleotide binding] 1127134013278 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1127134013279 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1127134013280 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1127134013281 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 1127134013282 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1127134013283 dimer interface [polypeptide binding]; other site 1127134013284 ssDNA binding site [nucleotide binding]; other site 1127134013285 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1127134013286 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 1127134013287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127134013288 S-adenosylmethionine binding site [chemical binding]; other site 1127134013289 Nitronate monooxygenase; Region: NMO; pfam03060 1127134013290 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1127134013291 FMN binding site [chemical binding]; other site 1127134013292 substrate binding site [chemical binding]; other site 1127134013293 putative catalytic residue [active] 1127134013294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127134013295 DNA-binding site [nucleotide binding]; DNA binding site 1127134013296 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127134013297 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1127134013298 active site 1127134013299 catalytic triad [active] 1127134013300 oxyanion hole [active] 1127134013301 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1127134013302 classical (c) SDRs; Region: SDR_c; cd05233 1127134013303 NAD(P) binding site [chemical binding]; other site 1127134013304 active site 1127134013305 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1127134013306 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1127134013307 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134013308 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134013309 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1127134013310 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1127134013311 FMN binding site [chemical binding]; other site 1127134013312 substrate binding site [chemical binding]; other site 1127134013313 putative catalytic residue [active] 1127134013314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127134013315 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127134013316 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1127134013317 active site 1127134013318 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1127134013319 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1127134013320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134013321 NAD(P) binding site [chemical binding]; other site 1127134013322 active site 1127134013323 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1127134013324 acyl-CoA synthetase; Validated; Region: PRK05850 1127134013325 AMP-binding enzyme; Region: AMP-binding; cl15778 1127134013326 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127134013327 RNA binding surface [nucleotide binding]; other site 1127134013328 NlpC/P60 family; Region: NLPC_P60; cl11438 1127134013329 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134013330 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1127134013331 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127134013332 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127134013333 active site 1127134013334 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134013335 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127134013336 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1127134013337 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1127134013338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134013339 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1127134013340 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1127134013341 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1127134013342 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134013343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134013344 non-specific DNA binding site [nucleotide binding]; other site 1127134013345 salt bridge; other site 1127134013346 sequence-specific DNA binding site [nucleotide binding]; other site 1127134013347 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1127134013348 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1127134013349 minor groove reading motif; other site 1127134013350 helix-hairpin-helix signature motif; other site 1127134013351 active site 1127134013352 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1127134013353 FAD binding domain; Region: FAD_binding_4; pfam01565 1127134013354 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1127134013355 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1127134013356 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134013357 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1127134013358 Walker A/P-loop; other site 1127134013359 ATP binding site [chemical binding]; other site 1127134013360 Q-loop/lid; other site 1127134013361 ABC transporter signature motif; other site 1127134013362 Walker B; other site 1127134013363 D-loop; other site 1127134013364 H-loop/switch region; other site 1127134013365 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1127134013366 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1127134013367 NADP binding site [chemical binding]; other site 1127134013368 dimer interface [polypeptide binding]; other site 1127134013369 DNA polymerase IV; Validated; Region: PRK03352 1127134013370 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1127134013371 active site 1127134013372 DNA binding site [nucleotide binding] 1127134013373 PemK-like protein; Region: PemK; cl00995 1127134013374 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127134013375 CoenzymeA binding site [chemical binding]; other site 1127134013376 subunit interaction site [polypeptide binding]; other site 1127134013377 PHB binding site; other site 1127134013378 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1127134013379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1127134013380 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1127134013381 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134013382 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127134013383 dimerization interface [polypeptide binding]; other site 1127134013384 putative DNA binding site [nucleotide binding]; other site 1127134013385 putative Zn2+ binding site [ion binding]; other site 1127134013386 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1127134013387 putative active site [active] 1127134013388 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1127134013389 Wyosine base formation; Region: Wyosine_form; pfam08608 1127134013390 Helix-turn-helix domains; Region: HTH; cl00088 1127134013391 hypothetical protein; Provisional; Region: PRK07233 1127134013392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1127134013393 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1127134013394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127134013395 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127134013396 hydrophobic ligand binding site; other site 1127134013397 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1127134013398 active site 1127134013399 RNA/DNA hybrid binding site [nucleotide binding]; other site 1127134013400 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134013401 mce related protein; Region: MCE; pfam02470 1127134013402 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1127134013403 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134013404 mce related protein; Region: MCE; pfam02470 1127134013405 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134013406 mce related protein; Region: MCE; pfam02470 1127134013407 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134013408 mce related protein; Region: MCE; pfam02470 1127134013409 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134013410 mce related protein; Region: MCE; pfam02470 1127134013411 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1127134013412 mce related protein; Region: MCE; pfam02470 1127134013413 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1127134013414 Permease; Region: Permease; cl00510 1127134013415 Permease; Region: Permease; cl00510 1127134013416 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1127134013417 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1127134013418 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1127134013419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1127134013420 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1127134013421 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1127134013422 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1127134013423 active site 1127134013424 Zn binding site [ion binding]; other site 1127134013425 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1127134013426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127134013427 non-specific DNA binding site [nucleotide binding]; other site 1127134013428 salt bridge; other site 1127134013429 sequence-specific DNA binding site [nucleotide binding]; other site 1127134013430 homoserine O-acetyltransferase; Provisional; Region: PRK08775 1127134013431 Cupin domain; Region: Cupin_2; cl09118 1127134013432 Pirin-related protein [General function prediction only]; Region: COG1741 1127134013433 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1127134013434 active site 1127134013435 8-oxo-dGMP binding site [chemical binding]; other site 1127134013436 nudix motif; other site 1127134013437 metal binding site [ion binding]; metal-binding site 1127134013438 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1127134013439 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1127134013440 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1127134013441 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1127134013442 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1127134013443 putative active site [active] 1127134013444 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1127134013445 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1127134013446 active site 1127134013447 NTP binding site [chemical binding]; other site 1127134013448 metal binding triad [ion binding]; metal-binding site 1127134013449 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1127134013450 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1127134013451 Zn2+ binding site [ion binding]; other site 1127134013452 Mg2+ binding site [ion binding]; other site 1127134013453 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1127134013454 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1127134013455 active site 1127134013456 Ap6A binding site [chemical binding]; other site 1127134013457 nudix motif; other site 1127134013458 metal binding site [ion binding]; metal-binding site 1127134013459 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1127134013460 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1127134013461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1127134013462 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1127134013463 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127134013464 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1127134013465 catalytic residues [active] 1127134013466 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1127134013467 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1127134013468 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1127134013469 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1127134013470 active site 1127134013471 metal binding site [ion binding]; metal-binding site 1127134013472 ParB-like partition proteins; Region: parB_part; TIGR00180 1127134013473 ParB-like nuclease domain; Region: ParBc; cl02129 1127134013474 KorB domain; Region: KorB; pfam08535 1127134013475 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1127134013476 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1127134013477 P-loop; other site 1127134013478 Magnesium ion binding site [ion binding]; other site 1127134013479 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1127134013480 Magnesium ion binding site [ion binding]; other site 1127134013481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1127134013482 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1127134013483 G-X-X-G motif; other site 1127134013484 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1127134013485 RxxxH motif; other site 1127134013486 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1127134013487 Haemolytic domain; Region: Haemolytic; cl00506 1127134013488 Ribonuclease P; Region: Ribonuclease_P; cl00457